Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0007_C17
(620 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 164 2e-40
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 164 2e-40
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 164 2e-40
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 161 1e-39
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 154 2e-37
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 153 6e-37
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 153 6e-37
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 146 7e-35
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 145 1e-34
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 145 1e-34
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 144 2e-34
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 122 1e-27
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 118 2e-26
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 110 3e-24
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 110 3e-24
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 110 3e-24
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 110 3e-24
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 110 3e-24
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 110 3e-24
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 72 1e-12
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 68 3e-11
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 164 bits (399), Expect = 2e-40
Identities = 84/170 (49%), Positives = 115/170 (67%), Gaps = 3/170 (1%)
Frame = +2
Query: 119 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 295
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 296 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 469
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 470 GAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
GAELD+DHPGF DPVYRARRK FADI YNY+HGQP+P V+Y +EE TWG
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWG 188
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 164 bits (399), Expect = 2e-40
Identities = 84/170 (49%), Positives = 115/170 (67%), Gaps = 3/170 (1%)
Frame = +2
Query: 119 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 295
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 296 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 469
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 470 GAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
GAELD+DHPGF DPVYRARRK FADI YNY+HGQP+P V+Y +EE TWG
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWG 188
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 164 bits (399), Expect = 2e-40
Identities = 84/170 (49%), Positives = 115/170 (67%), Gaps = 3/170 (1%)
Frame = +2
Query: 119 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 295
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 296 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 469
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 470 GAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
GAELD+DHPGF DPVYRARRK FADI YNY+HGQP+P V+Y +EE TWG
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWG 188
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 161 bits (392), Expect = 1e-39
Identities = 83/170 (48%), Positives = 114/170 (67%), Gaps = 3/170 (1%)
Frame = +2
Query: 119 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 295
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 296 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 469
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 470 GAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
GAELD+DHPGF DPVYRARRK FADI YNY+HGQP+P V+Y +E TWG
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWG 188
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 154 bits (374), Expect = 2e-37
Identities = 77/158 (48%), Positives = 100/158 (63%), Gaps = 5/158 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 337
L+FS +E G L + L IF VNL HIESR S RR +E V+C+ L
Sbjct: 18 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIL 75
Query: 338 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 76 HLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 135
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
D VYR RRKYFAD+ NYKHG P+P V++T+EEI TWG
Sbjct: 136 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWG 173
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 153 bits (370), Expect = 6e-37
Identities = 76/158 (48%), Positives = 99/158 (62%), Gaps = 5/158 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 337
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIF 77
Query: 338 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
D VYR RRKYFAD+ NYKHG P+P V++T+EEI TWG
Sbjct: 138 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWG 175
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 153 bits (370), Expect = 6e-37
Identities = 76/158 (48%), Positives = 99/158 (62%), Gaps = 5/158 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 337
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIF 77
Query: 338 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
D VYR RRKYFAD+ NYKHG P+P V++T+EEI TWG
Sbjct: 138 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWG 175
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 146 bits (353), Expect = 7e-35
Identities = 80/188 (42%), Positives = 110/188 (58%), Gaps = 5/188 (2%)
Frame = +2
Query: 71 KPTISPSDKPKLMEGGNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSH 250
KP +D K +G N RE + T ++FS +E G L + L +F VN+ H
Sbjct: 38 KPNSGKNDD-KGNKGSNK-REAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVH 93
Query: 251 IESRSSARRPG-YEFMVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPW 415
IESR S RR E V+CE G +F ++ LK + LN + + VPW
Sbjct: 94 IESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPW 153
Query: 416 FPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYT 595
FPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+ YK+GQP+P V+YT
Sbjct: 154 FPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYT 213
Query: 596 KEEIYTWG 619
+EE TWG
Sbjct: 214 EEETKTWG 221
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 145 bits (352), Expect = 1e-34
Identities = 75/173 (43%), Positives = 104/173 (60%), Gaps = 5/173 (2%)
Frame = +2
Query: 116 GNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEF 292
G+ RE + T ++FS +E G L + L +F VN+ HIESR S RR E
Sbjct: 57 GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEI 114
Query: 293 MVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPWFPRRIRDLDRFANQI 460
V+CE G +F ++ LK + LN + + VPWFPR+I +LD+ ++++
Sbjct: 115 FVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRV 174
Query: 461 LSYGAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
L YG+ELD+DHPGF D VYR RRKYF D+ YK+GQP+P V+YT+EE TWG
Sbjct: 175 LMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWG 227
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 145 bits (352), Expect = 1e-34
Identities = 75/173 (43%), Positives = 104/173 (60%), Gaps = 5/173 (2%)
Frame = +2
Query: 116 GNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEF 292
G+ RE + T ++FS +E G L + L +F VN+ HIESR S RR E
Sbjct: 51 GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEI 108
Query: 293 MVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPWFPRRIRDLDRFANQI 460
V+CE G +F ++ LK + LN + + VPWFPR+I +LD+ ++++
Sbjct: 109 FVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRV 168
Query: 461 LSYGAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
L YG+ELD+DHPGF D VYR RRKYF D+ YK+GQP+P V+YT+EE TWG
Sbjct: 169 LMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWG 221
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 144 bits (350), Expect = 2e-34
Identities = 73/158 (46%), Positives = 98/158 (62%), Gaps = 5/158 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 337
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIF 77
Query: 338 EELKKNVGYLNIISR-NY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
LK + L++ N+ ++ +VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTWG 619
D VYR RRKYFAD +YK+G P+P V++T+EEI TWG
Sbjct: 138 DNVYRKRRKYFADSAMSYKYGDPIPKVEFTEEEIKTWG 175
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 122 bits (293), Expect = 1e-27
Identities = 65/146 (44%), Positives = 84/146 (57%), Gaps = 5/146 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 337
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIF 77
Query: 338 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVNLPDNFTLNEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPH 583
D VYR RRKYFAD+ NYK H
Sbjct: 138 DNVYRKRRKYFADLAMNYKQAYRFFH 163
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 118 bits (284), Expect = 2e-26
Identities = 65/159 (40%), Positives = 91/159 (57%), Gaps = 5/159 (3%)
Frame = +2
Query: 116 GNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEF 292
G+ RE + T ++FS +E G L + L +F VN+ HIESR S RR E
Sbjct: 51 GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEI 108
Query: 293 MVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPWFPRRIRDLDRFANQI 460
V+CE G +F ++ LK + LN + + VPWFPR+I +LD+ ++++
Sbjct: 109 FVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRV 168
Query: 461 LSYGAELDSDHPGFTDPVYRARRKYFADIGYNYKHGQPL 577
L YG+ELD+DHPGF D VYR RRKYF D+ YK+G L
Sbjct: 169 LMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGPRL 207
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 110 bits (265), Expect = 3e-24
Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 5/157 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 328
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 111 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 169
Query: 329 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 170 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 222
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 223 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 259
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 110 bits (265), Expect = 3e-24
Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 5/157 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 328
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 329 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 110 bits (265), Expect = 3e-24
Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 5/157 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 328
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 115 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 173
Query: 329 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 174 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 226
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 227 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 263
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 110 bits (265), Expect = 3e-24
Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 5/157 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 328
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 88 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 146
Query: 329 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 147 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 199
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 200 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 110 bits (265), Expect = 3e-24
Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 5/157 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 328
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 329 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 110 bits (265), Expect = 3e-24
Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 5/157 (3%)
Frame = +2
Query: 161 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 328
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 329 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 505
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 506 DPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 232
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 72.1 bits (169), Expect = 1e-12
Identities = 28/45 (62%), Positives = 34/45 (75%)
Frame = +2
Query: 482 DSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYTW 616
D DHPGF+D VYR RRK A+I + Y+HG P+P V+YT EEI TW
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 45
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 67.7 bits (158), Expect = 3e-11
Identities = 27/44 (61%), Positives = 33/44 (75%)
Frame = +2
Query: 482 DSDHPGFTDPVYRARRKYFADIGYNYKHGQPLPHVDYTKEEIYT 613
D DHPGF+D VYR RRK A+I + Y+HG P+P V+YT EEI T
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 92,665,412
Number of Sequences: 237096
Number of extensions: 1922831
Number of successful extensions: 8459
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 8278
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8446
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6691573490
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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