Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0006_M19
(513 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q2F685 Cluster: Hydroxymethylglutaryl-CoA lyase isoform... 232 3e-60
UniRef50_P35914 Cluster: Hydroxymethylglutaryl-CoA lyase, mitoch... 152 5e-36
UniRef50_Q54QI7 Cluster: Hydroxymethylglutaryl-CoA lyase; n=4; c... 144 1e-33
UniRef50_UPI00015B4E2A Cluster: PREDICTED: similar to hydroxymet... 143 2e-33
UniRef50_Q8TB92 Cluster: 3-hydroxymethyl-3-methylglutaryl-CoA ly... 143 2e-33
UniRef50_Q1GIP4 Cluster: Hydroxymethylglutaryl-CoA lyase; n=20; ... 130 1e-29
UniRef50_Q7NX69 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3; P... 128 1e-28
UniRef50_Q4PD12 Cluster: Putative uncharacterized protein; n=1; ... 119 3e-26
UniRef50_A1SD09 Cluster: Pyruvate carboxyltransferase; n=5; Bact... 119 4e-26
UniRef50_Q6S014 Cluster: 3-hydroxy-3-methylglutaryl-coenzyme A l... 119 4e-26
UniRef50_Q0CWY1 Cluster: Hydroxymethylglutaryl-CoA lyase, mitoch... 118 1e-25
UniRef50_Q8D6M9 Cluster: Isopropylmalate/homocitrate/citramalate... 117 2e-25
UniRef50_Q0UL76 Cluster: Putative uncharacterized protein; n=1; ... 91 9e-25
UniRef50_UPI00005A02C5 Cluster: PREDICTED: similar to Hydroxymet... 112 5e-24
UniRef50_A7HCC2 Cluster: Pyruvate carboxyltransferase; n=7; Bact... 107 1e-22
UniRef50_A6CMV0 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; B... 105 4e-22
UniRef50_Q81Q83 Cluster: 3-hydroxy-3-methylglutarate-CoA lyase; ... 104 1e-21
UniRef50_O34873 Cluster: YngG protein; n=2; Bacteria|Rep: YngG p... 102 6e-21
UniRef50_A0KK03 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3; P... 101 7e-21
UniRef50_Q6MHG9 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; B... 101 1e-20
UniRef50_Q9P3J2 Cluster: Related to hydroxymethylglutaryl-CoA ly... 101 1e-20
UniRef50_Q2PQY9 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; R... 99 5e-20
UniRef50_Q9NT06 Cluster: Putative uncharacterized protein DKFZp4... 76 5e-20
UniRef50_Q28KR2 Cluster: Pyruvate carboxyltransferase; n=4; Prot... 96 5e-19
UniRef50_Q2B6B8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; B... 95 6e-19
UniRef50_A3JC95 Cluster: Pyruvate carboxyltransferase; n=3; Gamm... 95 6e-19
UniRef50_Q189Z3 Cluster: Putative hydroxymethylglutaryl-CoA lyas... 95 8e-19
UniRef50_Q1YEM8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=2; R... 93 3e-18
UniRef50_Q0VL35 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; A... 93 3e-18
UniRef50_Q2S361 Cluster: 3-hydroxy-3-methylglutaryl-CoA lyase; n... 91 1e-17
UniRef50_A5UPD9 Cluster: Pyruvate carboxyltransferase; n=4; Chlo... 91 1e-17
UniRef50_Q2GNI7 Cluster: Putative uncharacterized protein; n=1; ... 69 4e-17
UniRef50_Q7W6U5 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3; B... 89 4e-17
UniRef50_A5V0V3 Cluster: Pyruvate carboxyltransferase; n=5; Chlo... 89 4e-17
UniRef50_Q1AVC1 Cluster: Pyruvate carboxyltransferase; n=2; Acti... 89 7e-17
UniRef50_A1HRC2 Cluster: Pyruvate carboxyltransferase; n=1; Ther... 88 1e-16
UniRef50_Q8ELJ7 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; O... 85 7e-16
UniRef50_Q9F132 Cluster: Putative uncharacterized protein xlnI; ... 85 7e-16
UniRef50_Q5SI54 Cluster: Hydroxymethylglutaryl-CoA lyase like pr... 85 9e-16
UniRef50_A7D6W3 Cluster: Pyruvate carboxyltransferase; n=1; Halo... 85 9e-16
UniRef50_Q1YPG1 Cluster: Hydroxymethylglutaryl-CoA lyase; n=2; u... 84 2e-15
UniRef50_Q1EXX3 Cluster: Pyruvate carboxyltransferase; n=1; Clos... 84 2e-15
UniRef50_Q5KLA2 Cluster: Putative uncharacterized protein; n=1; ... 70 2e-15
UniRef50_UPI000050F9CC Cluster: COG0119: Isopropylmalate/homocit... 83 3e-15
UniRef50_A1WEM7 Cluster: Pyruvate carboxyltransferase; n=2; Coma... 83 5e-15
UniRef50_UPI000050F830 Cluster: COG0119: Isopropylmalate/homocit... 82 6e-15
UniRef50_A3WDQ0 Cluster: 3-hydroxy-3-methylglutarate-CoA lyase; ... 80 3e-14
UniRef50_A1W9T7 Cluster: Pyruvate carboxyltransferase; n=34; Pro... 79 4e-14
UniRef50_Q0S6H7 Cluster: Possible hydroxymethylglutaryl-CoA lyas... 78 1e-13
UniRef50_Q5WKL8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; B... 75 1e-12
UniRef50_Q9AAX5 Cluster: 3-hydroxy-3-methylglutarate-CoA lyase; ... 75 1e-12
UniRef50_A3JDD8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=2; P... 74 2e-12
UniRef50_Q89GI1 Cluster: Bll6364 protein; n=1; Bradyrhizobium ja... 73 3e-12
UniRef50_Q120B4 Cluster: Pyruvate carboxyltransferase; n=3; Prot... 73 5e-12
UniRef50_Q122Z2 Cluster: Pyruvate carboxyltransferase; n=64; Pro... 72 7e-12
UniRef50_A5P2D8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3; A... 71 1e-11
UniRef50_A6EGU7 Cluster: Hydroxymethylglutaryl-CoA lyase like pr... 71 2e-11
UniRef50_Q0FWC0 Cluster: Putative hydroxymethylglutaryl-CoA lyas... 71 2e-11
UniRef50_Q5ARE9 Cluster: Putative uncharacterized protein; n=1; ... 69 8e-11
UniRef50_A3I2Z1 Cluster: Hydroxymethylglutaryl-CoA lyase like pr... 68 1e-10
UniRef50_Q1IRS1 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; A... 67 2e-10
UniRef50_Q7VSS8 Cluster: Putative hydroxymethylglutaryl-CoA lyas... 66 3e-10
UniRef50_UPI0000510140 Cluster: COG0119: Isopropylmalate/homocit... 62 5e-09
UniRef50_A1UDB1 Cluster: Pyruvate carboxyltransferase; n=6; Acti... 61 2e-08
UniRef50_Q4AH02 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1; C... 58 9e-08
UniRef50_Q583A8 Cluster: 3-hydroxy-3-methylglutaryl-CoA lyase, p... 58 1e-07
UniRef50_Q4AF29 Cluster: HMG-CoA lyase-like; n=1; Chlorobium pha... 57 2e-07
UniRef50_A1T6B5 Cluster: Pyruvate carboxyltransferase; n=6; Myco... 55 8e-07
UniRef50_Q89WI9 Cluster: Blr0698 protein; n=1; Bradyrhizobium ja... 53 3e-06
UniRef50_A4C110 Cluster: Hydroxymethylglutaryl-CoA lyase like pr... 52 6e-06
UniRef50_Q0S6Y1 Cluster: Hydroxymethylglutaryl-CoA lyase; n=5; A... 45 9e-04
UniRef50_Q4MV51 Cluster: YngK protein; n=15; Bacillus|Rep: YngK ... 38 0.18
UniRef50_A6R9V0 Cluster: Putative uncharacterized protein; n=4; ... 37 0.31
UniRef50_Q6KH81 Cluster: Mg-dependent DNAse; n=1; Mycoplasma mob... 36 0.72
UniRef50_Q57926 Cluster: 2-isopropylmalate synthase 1; n=10; Eur... 34 1.7
UniRef50_Q21604 Cluster: Putative uncharacterized protein pan-1;... 34 2.2
UniRef50_A6LNL7 Cluster: Putative uncharacterized protein; n=1; ... 33 2.9
UniRef50_Q2UI00 Cluster: Cytochrome P450; n=1; Aspergillus oryza... 33 5.0
UniRef50_Q12W45 Cluster: Putative uncharacterized protein; n=1; ... 33 5.0
UniRef50_Q1GH47 Cluster: Putative uncharacterized protein; n=1; ... 32 6.7
UniRef50_A7AWL8 Cluster: DnaK family domain containing protein; ... 32 6.7
UniRef50_A2DYI5 Cluster: Putative uncharacterized protein; n=1; ... 32 6.7
UniRef50_A0D1L9 Cluster: Chromosome undetermined scaffold_34, wh... 32 6.7
UniRef50_A6RYF2 Cluster: Putative uncharacterized protein; n=1; ... 32 6.7
UniRef50_P38746 Cluster: Putative GTP-binding protein YLF2; n=4;... 32 6.7
UniRef50_Q5CWG7 Cluster: Ring finger protein; n=3; Cryptosporidi... 32 8.8
UniRef50_A2HDF9 Cluster: Putative uncharacterized protein; n=3; ... 32 8.8
UniRef50_A3GHW1 Cluster: Predicted protein; n=2; Pichia|Rep: Pre... 32 8.8
UniRef50_P24795 Cluster: Protein E15; n=1; Enterobacteria phage ... 32 8.8
>UniRef50_Q2F685 Cluster: Hydroxymethylglutaryl-CoA lyase isoform 1;
n=2; Bombyx mori|Rep: Hydroxymethylglutaryl-CoA lyase
isoform 1 - Bombyx mori (Silk moth)
Length = 338
Score = 232 bits (568), Expect = 3e-60
Identities = 110/142 (77%), Positives = 125/142 (88%), Gaps = 1/142 (0%)
Frame = +3
Query: 90 LKAIRSISNLKH-MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIE 266
L +RS + L+ +ST P+IRIYEVGPRDGLQNESKFVPTDIK+ELI+K+V AG+KN+E
Sbjct: 10 LNILRSNNFLQRSLSTVAPEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVE 69
Query: 267 SASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSE 446
SASFVSPKW+KQMSD V+VMKN+ +V VNYPVLVPNLKGY AKQCNVEE+AIFPAGSE
Sbjct: 70 SASFVSPKWVKQMSDSVDVMKNIQRVPGVNYPVLVPNLKGYETAKQCNVEEIAIFPAGSE 129
Query: 447 GFSQKNLNCSVEEGLRRFTDVA 512
GFSQKNLNCSVEEGLRRF VA
Sbjct: 130 GFSQKNLNCSVEEGLRRFKQVA 151
>UniRef50_P35914 Cluster: Hydroxymethylglutaryl-CoA lyase,
mitochondrial precursor; n=227; root|Rep:
Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
- Homo sapiens (Human)
Length = 325
Score = 152 bits (368), Expect = 5e-36
Identities = 72/141 (51%), Positives = 96/141 (68%)
Frame = +3
Query: 78 RIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLK 257
R++ L ++R++S M T ++I EVGPRDGLQNE V T +KI+LI+ L +AGL
Sbjct: 11 RLVGLASLRAVST-SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLS 69
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPA 437
IE+ SFVSPKW+ QM D EV+K + K +NYPVL PNLKG+ A +EV IF A
Sbjct: 70 VIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGA 129
Query: 438 GSEGFSQKNLNCSVEEGLRRF 500
SE F++KN+NCS+EE +RF
Sbjct: 130 ASELFTKKNINCSIEESFQRF 150
>UniRef50_Q54QI7 Cluster: Hydroxymethylglutaryl-CoA lyase; n=4;
cellular organisms|Rep: Hydroxymethylglutaryl-CoA lyase
- Dictyostelium discoideum AX4
Length = 406
Score = 144 bits (349), Expect = 1e-33
Identities = 64/121 (52%), Positives = 87/121 (71%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDGLQNE VPT KI+LIN+L Q GL +E+ SFVSPKW+ QM+D EV+
Sbjct: 54 VKIVEVGPRDGLQNEKIIVPTVDKIQLINRLAQTGLSVVEATSFVSPKWVPQMADNKEVL 113
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
+ + KV V+YP L PN++G+ A +E+A+F A SE FS+KN+N ++EE L R+ D
Sbjct: 114 RGIEKVEGVSYPCLTPNIQGFRAALDAGAKEIALFAAASESFSKKNINATIEESLARYKD 173
Query: 507 V 509
V
Sbjct: 174 V 174
>UniRef50_UPI00015B4E2A Cluster: PREDICTED: similar to
hydroxymethylglutaryl-coa lyase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to
hydroxymethylglutaryl-coa lyase - Nasonia vitripennis
Length = 327
Score = 143 bits (347), Expect = 2e-33
Identities = 67/121 (55%), Positives = 87/121 (71%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+RI EVGPRDGLQN K +PT+ KIELIN+L Q GL+++E SFVSPKW+ QM+D EV
Sbjct: 27 VRIVEVGPRDGLQNIRKVLPTETKIELINRLSQTGLRSVEVTSFVSPKWVPQMADSAEVY 86
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
+ + K NV Y VLVPNLKG A + V+EV +F A SE F+QKN+NCS+ E L+ +
Sbjct: 87 QGVEKNPNVEYSVLVPNLKGLDKALKLGVKEVVLFTAASETFNQKNINCSIAESLKNCKE 146
Query: 507 V 509
+
Sbjct: 147 I 147
>UniRef50_Q8TB92 Cluster: 3-hydroxymethyl-3-methylglutaryl-CoA
lyase-like protein 1; n=37; cellular organisms|Rep:
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein
1 - Homo sapiens (Human)
Length = 340
Score = 143 bits (347), Expect = 2e-33
Identities = 66/121 (54%), Positives = 85/121 (70%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ QM+D EVM
Sbjct: 48 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVM 107
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
K + + V YPVL PNL+G+ A E+++F A SE FS+KN+NCS+EE + +F +
Sbjct: 108 KGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEE 167
Query: 507 V 509
V
Sbjct: 168 V 168
>UniRef50_Q1GIP4 Cluster: Hydroxymethylglutaryl-CoA lyase; n=20;
Bacteria|Rep: Hydroxymethylglutaryl-CoA lyase -
Silicibacter sp. (strain TM1040)
Length = 288
Score = 130 bits (315), Expect = 1e-29
Identities = 58/121 (47%), Positives = 79/121 (65%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I+EVGPRDGLQNE + +P K+ L++ L +AG IE ASFVSPKW+ QM+ EV+
Sbjct: 5 VEIFEVGPRDGLQNEKRDIPVADKVALVDCLSRAGFSRIEVASFVSPKWVPQMAGSAEVL 64
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
+ K V Y L PN++GY A +E+AIF + SEGFSQ N+N S+ E + RFT
Sbjct: 65 AGITKAKGVRYAALTPNMRGYEDALAARADEIAIFASASEGFSQANINASIAESIERFTP 124
Query: 507 V 509
+
Sbjct: 125 I 125
>UniRef50_Q7NX69 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3;
Proteobacteria|Rep: Hydroxymethylglutaryl-CoA lyase -
Chromobacterium violaceum
Length = 297
Score = 128 bits (308), Expect = 1e-28
Identities = 61/122 (50%), Positives = 79/122 (64%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDGLQNE + + +IK+ELI +L GL IE+ +FVSPKW+ QM+ EV+
Sbjct: 4 VKIVEVGPRDGLQNEKRPLSAEIKLELIRRLAGTGLSAIEAGAFVSPKWVPQMAGSAEVL 63
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
L + YPVLVPN G A E+A+F A SE FSQKN+N S+ E L+RF
Sbjct: 64 AALDTTGAIAYPVLVPNDMGLDAALAAGAREIAVFGAASESFSQKNINASIAESLQRFAS 123
Query: 507 VA 512
VA
Sbjct: 124 VA 125
>UniRef50_Q4PD12 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 353
Score = 119 bits (287), Expect = 3e-26
Identities = 61/134 (45%), Positives = 83/134 (61%), Gaps = 12/134 (8%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EV PRDGLQNE VPT KIELI +L + G+ IE+ SFVSPKW+ QM D +V+
Sbjct: 29 VKIVEVSPRDGLQNEKTIVPTATKIELIRRLAETGVPVIEAGSFVSPKWVPQMGDTPQVV 88
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVE------------EVAIFPAGSEGFSQKNLN 470
+P +++YPVLVPN++G ++ E E+AIF A SE F + N N
Sbjct: 89 AQMPVHPSISYPVLVPNMRGLEALQKLLAEYKDASKRVPPTDEIAIFTAASESFCKANTN 148
Query: 471 CSVEEGLRRFTDVA 512
C++ E L R +DVA
Sbjct: 149 CTIAESLDRLSDVA 162
>UniRef50_A1SD09 Cluster: Pyruvate carboxyltransferase; n=5;
Bacteria|Rep: Pyruvate carboxyltransferase -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 315
Score = 119 bits (286), Expect = 4e-26
Identities = 60/122 (49%), Positives = 80/122 (65%), Gaps = 1/122 (0%)
Frame = +3
Query: 138 VPD-IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDG 314
+PD + IYEVGPRDGLQNE VPTD+K E + +L+ AGL +E+ SFV PKW+ Q++D
Sbjct: 17 MPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVEATSFVHPKWVPQLADA 76
Query: 315 VEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLR 494
E+M L + PVLVPN +G A + V VAIF + +E F+QKNLN S++E
Sbjct: 77 AELMALLGPAGR-DCPVLVPNERGLDRALELGVRHVAIFGSATETFAQKNLNRSLDEQFA 135
Query: 495 RF 500
F
Sbjct: 136 MF 137
>UniRef50_Q6S014 Cluster: 3-hydroxy-3-methylglutaryl-coenzyme A
lyase/3-methylglutaconyl- coenzyme A hydratase; n=3;
Trichocomaceae|Rep: 3-hydroxy-3-methylglutaryl-coenzyme
A lyase/3-methylglutaconyl- coenzyme A hydratase -
Emericella nidulans (Aspergillus nidulans)
Length = 599
Score = 119 bits (286), Expect = 4e-26
Identities = 63/134 (47%), Positives = 87/134 (64%), Gaps = 5/134 (3%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
M S +RI EVGPRDGLQN + + + IK++LI +L AGL+ IE SFVSP+ + Q+
Sbjct: 1 MQNSTKTVRIVEVGPRDGLQNIPQSIDSTIKLDLIRRLRDAGLQTIELTSFVSPRAIPQL 60
Query: 306 SDGVEVMKN-----LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLN 470
+D V++N L K + PVLVPNLKG A ++EVA+F + +EGFS+ N+N
Sbjct: 61 ADAQVVVQNADIQKLLKNPKLRLPVLVPNLKGLERALHNGIKEVAVFISATEGFSRANIN 120
Query: 471 CSVEEGLRRFTDVA 512
C+V+EGL R VA
Sbjct: 121 CTVDEGLERARQVA 134
>UniRef50_Q0CWY1 Cluster: Hydroxymethylglutaryl-CoA lyase,
mitochondrial; n=5; Trichocomaceae|Rep:
Hydroxymethylglutaryl-CoA lyase, mitochondrial -
Aspergillus terreus (strain NIH 2624)
Length = 552
Score = 118 bits (283), Expect = 1e-25
Identities = 62/127 (48%), Positives = 85/127 (66%), Gaps = 5/127 (3%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+RI EVGPRDGLQN V T +K+ELI +L ++GL IE S VSP+ + Q++D EV+
Sbjct: 8 VRIVEVGPRDGLQNIKDPVATSVKLELIRRLRESGLSTIELTSIVSPRAVPQLADCREVL 67
Query: 327 -----KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
K L + + +PVLVPN KG IA + V+EVA+F + +EGFS+ N+NCSV EG+
Sbjct: 68 RDQTIKQLQQHDGLRFPVLVPNPKGLDIALEYGVKEVAVFVSATEGFSKANINCSVGEGI 127
Query: 492 RRFTDVA 512
R + VA
Sbjct: 128 ERASRVA 134
>UniRef50_Q8D6M9 Cluster: Isopropylmalate/homocitrate/citramalate
synthase; n=4; cellular organisms|Rep:
Isopropylmalate/homocitrate/citramalate synthase -
Vibrio vulnificus
Length = 179
Score = 117 bits (281), Expect = 2e-25
Identities = 60/135 (44%), Positives = 84/135 (62%), Gaps = 1/135 (0%)
Frame = +3
Query: 108 ISNLKHMSTSVPD-IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVS 284
+S + ++P+ + I EVGPRDGLQNE V TD K+ LIN L Q GL IE+ +FVS
Sbjct: 1 MSRFSAENLTLPEHVTIVEVGPRDGLQNEGA-VSTDSKVALINALSQTGLTRIEAGAFVS 59
Query: 285 PKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKN 464
K + QM+D + V + + + V Y L PN++G+ A V+ VA+F + SEGFSQ N
Sbjct: 60 AKRVPQMADSLAVFEQIHRSLGVQYSALTPNMQGFQAAVSAQVDHVAVFASCSEGFSQHN 119
Query: 465 LNCSVEEGLRRFTDV 509
++CS+ E L RF V
Sbjct: 120 IHCSIAESLERFQPV 134
>UniRef50_Q0UL76 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 384
Score = 90.6 bits (215), Expect(2) = 9e-25
Identities = 46/91 (50%), Positives = 63/91 (69%), Gaps = 5/91 (5%)
Frame = +3
Query: 129 STSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMS 308
S+ +RI EVGPRDGLQNE + +P KIEL+ +L Q+GL+ IE+ SFVSPKW+ QM+
Sbjct: 29 SSRADHVRIVEVGPRDGLQNEKQSIPVATKIELVERLAQSGLEYIEAGSFVSPKWVPQMA 88
Query: 309 DGVE----VMKNLPKV-HNVNYPVLVPNLKG 386
+ E V+KN K+ NV Y L+PN++G
Sbjct: 89 NSSEILEHVLKNKSKLPQNVVYQWLLPNVRG 119
Score = 45.2 bits (102), Expect(2) = 9e-25
Identities = 19/46 (41%), Positives = 28/46 (60%)
Frame = +3
Query: 372 PNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
PN G +++ EV+IF A +E F++KN NCS+ E L RF +
Sbjct: 159 PNAMGSTLSSSGTRHEVSIFTAATESFTRKNTNCSIAESLERFKPI 204
>UniRef50_UPI00005A02C5 Cluster: PREDICTED: similar to
Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
(HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA
lyase) isoform 2; n=1; Canis lupus familiaris|Rep:
PREDICTED: similar to Hydroxymethylglutaryl-CoA lyase,
mitochondrial precursor (HMG-CoA lyase) (HL)
(3-hydroxy-3-methylglutarate-CoA lyase) isoform 2 -
Canis familiaris
Length = 191
Score = 112 bits (269), Expect = 5e-24
Identities = 54/121 (44%), Positives = 78/121 (64%)
Frame = +3
Query: 78 RIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLK 257
R++ L ++R++S + T ++I EVG RDGLQNE V T KI+LI+ L +AGL
Sbjct: 11 RLVGLASLRAVSTFS-LGTFPKQVKIVEVGARDGLQNEKNIVSTSTKIKLIDMLSEAGLP 69
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPA 437
IE+ SFVSPKW+ QM+D EV+K + K +NYPVL PN+KG+ A +V + ++
Sbjct: 70 VIEATSFVSPKWVPQMADCAEVLKGIQKFPGINYPVLTPNIKGFQAAMGVSVVDSSVAGL 129
Query: 438 G 440
G
Sbjct: 130 G 130
>UniRef50_A7HCC2 Cluster: Pyruvate carboxyltransferase; n=7;
Bacteria|Rep: Pyruvate carboxyltransferase -
Anaeromyxobacter sp. Fw109-5
Length = 315
Score = 107 bits (257), Expect = 1e-22
Identities = 55/125 (44%), Positives = 77/125 (61%), Gaps = 8/125 (6%)
Frame = +3
Query: 141 PDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVE 320
P + +YEVGPRDGLQNE+K VP+ K+ L+ L AGL+ IE+ SFVSP+W+ Q++D E
Sbjct: 3 PRVTVYEVGPRDGLQNEAKTVPSGDKLALVRALAGAGLRRIEATSFVSPRWIPQLADAAE 62
Query: 321 VMKNLPKVHNVNYPVLVPNLKGYSIAKQC--------NVEEVAIFPAGSEGFSQKNLNCS 476
V LP+V V+Y VLVPN KG + + A+F + SE S++N+N
Sbjct: 63 VTAALPRVPGVSYVVLVPNAKGLERLGEALGRAGPDHPPVDAAVFLSASETHSRRNINKG 122
Query: 477 VEEGL 491
+ E L
Sbjct: 123 IAEAL 127
>UniRef50_A6CMV0 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Bacillus sp. SG-1|Rep: Hydroxymethylglutaryl-CoA lyase -
Bacillus sp. SG-1
Length = 311
Score = 105 bits (253), Expect = 4e-22
Identities = 53/121 (43%), Positives = 74/121 (61%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ + EVGPRDGLQNE FVPTDIKI+ I L +AGLK +E SFVSPKW+ QM D E++
Sbjct: 20 VTMIEVGPRDGLQNEKNFVPTDIKIQFIRALKEAGLKEMELTSFVSPKWVPQMKDASEIV 79
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
++ +++ VL PN KG + + VA+F S F++KN+N + E L
Sbjct: 80 ESC--LNSERDIVLAPNRKGVDRVLETKGKAVAVFVGVSNSFNKKNINKTTAESLEELKP 137
Query: 507 V 509
+
Sbjct: 138 I 138
>UniRef50_Q81Q83 Cluster: 3-hydroxy-3-methylglutarate-CoA lyase;
n=27; Bacteria|Rep: 3-hydroxy-3-methylglutarate-CoA
lyase - Bacillus anthracis
Length = 303
Score = 104 bits (249), Expect = 1e-21
Identities = 53/119 (44%), Positives = 72/119 (60%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
I EVGPRDGLQNE K V T K++ I L +AGL +E +SFV PKW+ ++D +V
Sbjct: 9 IKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHPKWVPALADANDVFSE 68
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
L + NV Y LVPN G A NV+EV +F + SE ++ N+N S++E L D+
Sbjct: 69 LKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSASESHNKSNINKSIKEALVVIEDI 127
>UniRef50_O34873 Cluster: YngG protein; n=2; Bacteria|Rep: YngG
protein - Bacillus subtilis
Length = 299
Score = 102 bits (244), Expect = 6e-21
Identities = 49/115 (42%), Positives = 69/115 (60%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I EVGPRDGLQNE ++ T+ KI IN+L + GL IE SFV PKW+ + D ++V
Sbjct: 7 VTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAIDVA 66
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
K + + V Y LVPN +G A + + E +F + SE ++KN+N S E L
Sbjct: 67 KGIDREKGVTYAALVPNQRGLENALEGGINEACVFMSASETHNRKNINKSTSESL 121
>UniRef50_A0KK03 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3;
Proteobacteria|Rep: Hydroxymethylglutaryl-CoA lyase -
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966
/ NCIB 9240)
Length = 318
Score = 101 bits (243), Expect = 7e-21
Identities = 49/118 (41%), Positives = 74/118 (62%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ + E+GPRDGLQNE+ + ++ELI +L ++GL+ IE +FVSP+ + QM+D +
Sbjct: 12 VSLVEMGPRDGLQNEAATLSLMQRLELIARLAESGLQRIEVGAFVSPRKVPQMADSAALF 71
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRF 500
LP+ Y LVPNL+G A +E+ +F A S+GF++ N+ SVEE L RF
Sbjct: 72 NALPRRGPTRYGALVPNLQGLQAAIAARADEIGLFTACSDGFTRANIGISVEESLVRF 129
>UniRef50_Q6MHG9 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Bdellovibrio bacteriovorus|Rep:
Hydroxymethylglutaryl-CoA lyase - Bdellovibrio
bacteriovorus
Length = 311
Score = 101 bits (242), Expect = 1e-20
Identities = 55/128 (42%), Positives = 76/128 (59%), Gaps = 9/128 (7%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMK- 329
I E+G RDGLQNE + D ++E +L+ AG K +E +FVSP W+ QM+ EV++
Sbjct: 7 IVEMGLRDGLQNEKTVLDADTRVEFARRLILAGTKRVEIGAFVSPTWVPQMAGTAEVVQK 66
Query: 330 --------NLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
++PK + VLVPN +G A V+EVAIF A SE FS KN+NCS++E
Sbjct: 67 TFALVKSGSIPK--KTEFSVLVPNERGMMDAIASGVKEVAIFAACSESFSLKNINCSIDE 124
Query: 486 GLRRFTDV 509
+RF V
Sbjct: 125 SFKRFEPV 132
>UniRef50_Q9P3J2 Cluster: Related to hydroxymethylglutaryl-CoA
lyase; n=5; Pezizomycotina|Rep: Related to
hydroxymethylglutaryl-CoA lyase - Neurospora crassa
Length = 395
Score = 101 bits (242), Expect = 1e-20
Identities = 60/150 (40%), Positives = 85/150 (56%), Gaps = 29/150 (19%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDGLQNE K +P KIELI +L + GL+ IE+ +FVSPKW+ QM++ E++
Sbjct: 56 VKIVEVGPRDGLQNEKKSIPLATKIELIERLAKTGLQTIEAGAFVSPKWVPQMANSDEIL 115
Query: 327 KNL-----PKVHNVNYPVLVPNLKG----------YSIAKQCNVE--------------E 419
++L P + + L PN KG Y A + E
Sbjct: 116 EHLLKTPPPSPVPLTFSFLAPNTKGLESALSILGKYPDAYETETTRSGKSAQEGGKPALE 175
Query: 420 VAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
+A+F A +E FSQKNLNCS++ LR+F +V
Sbjct: 176 IAVFAAATESFSQKNLNCSIDASLRQFKEV 205
>UniRef50_Q2PQY9 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Rhodococcus sp. T104|Rep: Hydroxymethylglutaryl-CoA
lyase - Rhodococcus sp. T104
Length = 307
Score = 99.1 bits (236), Expect = 5e-20
Identities = 53/115 (46%), Positives = 73/115 (63%), Gaps = 2/115 (1%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDG QNE + +PTD K+ LIN L +AG IE ASFV P + Q++DGVEV+
Sbjct: 7 VQIREVGPRDGFQNEPERIPTDDKVRLINALGRAGFTRIEVASFVRPDVIPQLADGVEVL 66
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQC--NVEEVAIFPAGSEGFSQKNLNCSVEE 485
+ + VLVPN +G A + EVAIF + SE ++KN+N +V+E
Sbjct: 67 ERIEVPDETKLMVLVPNSRGLENALKVRDKFHEVAIFVSASETHNKKNVNRTVDE 121
>UniRef50_Q9NT06 Cluster: Putative uncharacterized protein
DKFZp434G1411; n=3; Tetrapoda|Rep: Putative
uncharacterized protein DKFZp434G1411 - Homo sapiens
(Human)
Length = 157
Score = 76.2 bits (179), Expect(2) = 5e-20
Identities = 35/56 (62%), Positives = 42/56 (75%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDG 314
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ Q++ G
Sbjct: 54 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQVAAG 109
Score = 43.6 bits (98), Expect(2) = 5e-20
Identities = 16/31 (51%), Positives = 25/31 (80%)
Frame = +3
Query: 417 EVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
E+++F A SE FS+KN+NCS+EE + +F +V
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEV 142
>UniRef50_Q28KR2 Cluster: Pyruvate carboxyltransferase; n=4;
Proteobacteria|Rep: Pyruvate carboxyltransferase -
Jannaschia sp. (strain CCS1)
Length = 319
Score = 95.9 bits (228), Expect = 5e-19
Identities = 47/122 (38%), Positives = 72/122 (59%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ + EVGPRDG Q+E F+PT KIE+ N + AGL++I+ SFVSP+ + Q++D +++
Sbjct: 14 VTVCEVGPRDGFQSEKTFIPTARKIEIANAMFAAGLRHIQVTSFVSPRAVPQLADAAKLI 73
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
L + L+PNLKG A V+ V + SE + KN+N +++ L F D
Sbjct: 74 AGLDRPDGAVVSALIPNLKGAERAAAAGVDAVHTVVSASETHNLKNVNRPIDQSLADFED 133
Query: 507 VA 512
VA
Sbjct: 134 VA 135
>UniRef50_Q2B6B8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Bacillus sp. NRRL B-14911|Rep: Hydroxymethylglutaryl-CoA
lyase - Bacillus sp. NRRL B-14911
Length = 308
Score = 95.5 bits (227), Expect = 6e-19
Identities = 49/113 (43%), Positives = 66/113 (58%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
I EVGPRDGLQNE F+PT +K E I+ L +AG +E SFVSPKW+ QM+D E+ +
Sbjct: 11 IIEVGPRDGLQNEKTFIPTPVKKEFISALKKAGFAEMELTSFVSPKWVPQMADAAEIAAS 70
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
V VL PN KG A +A+F S+ F++KN+N + E +
Sbjct: 71 -SIGSGVRDFVLAPNRKGIERAYMTGCRAIAVFVGVSDSFNKKNINKTTAESM 122
>UniRef50_A3JC95 Cluster: Pyruvate carboxyltransferase; n=3;
Gammaproteobacteria|Rep: Pyruvate carboxyltransferase -
Marinobacter sp. ELB17
Length = 308
Score = 95.5 bits (227), Expect = 6e-19
Identities = 48/113 (42%), Positives = 71/113 (62%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
IRI EVGPRDGLQ++ K + + ++ LI LV+ GLKN+E+ SFVSPK + QM+ ++
Sbjct: 3 IRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAGSFVSPKAVPQMAGTDDLF 62
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
LP+ V Y LVPN+KGY +A V + + +E +QKN+ S+ +
Sbjct: 63 ALLPERSAVRYAGLVPNMKGYELAVAAGANVVNVVLSVTETMNQKNIRMSLPQ 115
>UniRef50_Q189Z3 Cluster: Putative hydroxymethylglutaryl-CoA lyase;
n=3; Clostridium difficile|Rep: Putative
hydroxymethylglutaryl-CoA lyase - Clostridium difficile
(strain 630)
Length = 298
Score = 95.1 bits (226), Expect = 8e-19
Identities = 47/116 (40%), Positives = 75/116 (64%), Gaps = 1/116 (0%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I+EVGPRDG QN +F+ TD K+++I+ L+ +G+K +E +SFVSPK + QM D EV
Sbjct: 4 VNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEISSFVSPKAIPQMKDAKEVA 63
Query: 327 KN-LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ K +V LVPNL G +A +C + +++ + SE ++KN+N + EE +
Sbjct: 64 TYCVEKYPDVKLYALVPNLYGAKVAWECGIRDISYVISLSETHNKKNINRTHEESI 119
>UniRef50_Q1YEM8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=2;
Rhizobiales|Rep: Hydroxymethylglutaryl-CoA lyase -
Aurantimonas sp. SI85-9A1
Length = 322
Score = 93.1 bits (221), Expect = 3e-18
Identities = 48/129 (37%), Positives = 74/129 (57%), Gaps = 1/129 (0%)
Frame = +3
Query: 126 MSTSVP-DIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQ 302
M+ S+P +RI EVGPRDGLQNE K++PTD KIEL+ +L AGL IE SF PKW+
Sbjct: 10 MTLSLPAKVRIVEVGPRDGLQNEPKYLPTDQKIELVRRLAAAGLTEIEVTSFTHPKWIPN 69
Query: 303 MSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVE 482
++D EV + + + + L+PN +G A + V + + ++ + NLN + E
Sbjct: 70 LADAEEVTRAVADLPITPF-ALIPNRRGLDRAMAAGAKGVTLVVSVTDAHNTANLNRTTE 128
Query: 483 EGLRRFTDV 509
+ ++
Sbjct: 129 ASVTELLEL 137
>UniRef50_Q0VL35 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Alcanivorax borkumensis SK2|Rep:
Hydroxymethylglutaryl-CoA lyase - Alcanivorax
borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Length = 350
Score = 93.1 bits (221), Expect = 3e-18
Identities = 45/111 (40%), Positives = 70/111 (63%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
I EVG RDGLQN+ V T K +L LV AG++ +E SFVSPK + QM+D +
Sbjct: 50 INEVGLRDGLQNQPVTVDTATKAKLAQLLVDAGMRYLEPVSFVSPKAIPQMADAAALTPL 109
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
LP+ ++++Y L+PNLKGY +A+ V + + ++ F+++NL S+E+
Sbjct: 110 LPQGNDLHYTALIPNLKGYQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQ 160
>UniRef50_Q2S361 Cluster: 3-hydroxy-3-methylglutaryl-CoA lyase; n=2;
Bacteria|Rep: 3-hydroxy-3-methylglutaryl-CoA lyase -
Salinibacter ruber (strain DSM 13855)
Length = 307
Score = 91.5 bits (217), Expect = 1e-17
Identities = 48/126 (38%), Positives = 70/126 (55%), Gaps = 1/126 (0%)
Frame = +3
Query: 135 SVPD-IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSD 311
S+P + + +VGPRDG Q E +F+PTD K+++I L AGL I+ SFV PKW+ QM D
Sbjct: 2 SLPQSVALCDVGPRDGFQFEEQFIPTDRKVDVITALADAGLPRIQVTSFVHPKWVPQMKD 61
Query: 312 GVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
V LP +V Y L N +G A + +V + A + SQ N N +V+E +
Sbjct: 62 AEAVCSRLPDRADVTYAGLALNQRGLERAHAAGLSQVDLSIATHDRHSQDNANRTVDEAV 121
Query: 492 RRFTDV 509
+ D+
Sbjct: 122 AQADDM 127
>UniRef50_A5UPD9 Cluster: Pyruvate carboxyltransferase; n=4;
Chloroflexaceae|Rep: Pyruvate carboxyltransferase -
Roseiflexus sp. RS-1
Length = 304
Score = 91.1 bits (216), Expect = 1e-17
Identities = 44/123 (35%), Positives = 68/123 (55%)
Frame = +3
Query: 144 DIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEV 323
DI I +V PRDGLQNE + +P K+ LI +LV++G+ +E +FV+P+ + Q + EV
Sbjct: 7 DITIIDVAPRDGLQNEPEILPVVTKVALIRRLVESGIPWVEIGAFVNPRQVPQQAGTTEV 66
Query: 324 MKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFT 503
L + L+PN++GY +A + V + A SE +Q N SV + L F
Sbjct: 67 AMALTDGETARFTCLIPNMRGYELAVAAGMRHVRLVLAASESLNQANFKRSVSDSLADFA 126
Query: 504 DVA 512
+A
Sbjct: 127 HIA 129
>UniRef50_Q2GNI7 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 595
Score = 68.5 bits (160), Expect(2) = 4e-17
Identities = 29/51 (56%), Positives = 38/51 (74%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMK 299
+++ EVGPRDGLQNE + +P K+ELI +L + GL IE+ SFVSPKW K
Sbjct: 340 VKLVEVGPRDGLQNEKRAIPLATKLELIERLAKTGLTTIEAGSFVSPKWDK 390
Score = 41.5 bits (93), Expect(2) = 4e-17
Identities = 16/31 (51%), Positives = 22/31 (70%)
Frame = +3
Query: 417 EVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
E+A+F + +E FSQ+NLNC + L RF DV
Sbjct: 394 EIAVFASATESFSQRNLNCDIATSLARFRDV 424
>UniRef50_Q7W6U5 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3;
Burkholderiales|Rep: Hydroxymethylglutaryl-CoA lyase -
Bordetella parapertussis
Length = 308
Score = 89.4 bits (212), Expect = 4e-17
Identities = 44/116 (37%), Positives = 72/116 (62%), Gaps = 1/116 (0%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
I I +V PRDGLQN+ VPT K+ LI L +AG++++E+ SFVSP+ + QM+D E++
Sbjct: 5 IHITDVSPRDGLQNQPAQVPTQEKLRLIRLLAEAGVRSVEATSFVSPRAVPQMADAAELV 64
Query: 327 KNL-PKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ + ++ VLVPNLKG A E+A+ + +E ++KN+N + + +
Sbjct: 65 AQVHAALPDLRTSVLVPNLKGLERALAAGAREIAVVLSATETMNRKNINMGLAQAV 120
>UniRef50_A5V0V3 Cluster: Pyruvate carboxyltransferase; n=5;
Chloroflexi (class)|Rep: Pyruvate carboxyltransferase -
Roseiflexus sp. RS-1
Length = 328
Score = 89.4 bits (212), Expect = 4e-17
Identities = 47/125 (37%), Positives = 71/125 (56%), Gaps = 1/125 (0%)
Frame = +3
Query: 141 PD-IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGV 317
PD + I EVGPRDGLQNE + T K++LI++L GL IE +FV P + QM+D
Sbjct: 23 PDHVSIREVGPRDGLQNEDVILTTTQKVQLIDRLADTGLTLIEVGAFVRPANVPQMADTA 82
Query: 318 EVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRR 497
+V + + V Y +VPN G A + + +F + SE ++ N+N S+E+ L +
Sbjct: 83 DVFAAISRRPGVVYSAIVPNAIGARRAVAAQADALQVFLSASESHNRSNVNMSIEQSLAQ 142
Query: 498 FTDVA 512
D+A
Sbjct: 143 AADIA 147
>UniRef50_Q1AVC1 Cluster: Pyruvate carboxyltransferase; n=2;
Actinobacteria (class)|Rep: Pyruvate carboxyltransferase
- Rubrobacter xylanophilus (strain DSM 9941 / NBRC
16129)
Length = 297
Score = 88.6 bits (210), Expect = 7e-17
Identities = 46/114 (40%), Positives = 72/114 (63%), Gaps = 1/114 (0%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ + +VGPRDGLQNE K + +++ EL ++L AGL+ +E+ASFV+P+ + QM+ EVM
Sbjct: 3 VEVVDVGPRDGLQNEEKILSPEVRAELCDRLAGAGLRRMEAASFVNPRLVPQMAGAEEVM 62
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVA-IFPAGSEGFSQKNLNCSVEE 485
L + V+Y LV N +GY A V+EV FP ++ F+++N N + E
Sbjct: 63 AALNRRPEVSYAGLVLNERGYERAVAAGVDEVRYAFPV-TDSFARRNQNTTAGE 115
>UniRef50_A1HRC2 Cluster: Pyruvate carboxyltransferase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Pyruvate
carboxyltransferase - Thermosinus carboxydivorans Nor1
Length = 303
Score = 87.8 bits (208), Expect = 1e-16
Identities = 45/118 (38%), Positives = 72/118 (61%), Gaps = 3/118 (2%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ + EVGPRDG QN F+PT +K+++I +L+ AG++ +E SFV PK + QM+D E+
Sbjct: 8 VEVVEVGPRDGFQNIKTFIPTAVKLQIIAQLIAAGVRKMEVTSFVHPKAIPQMADAAEIA 67
Query: 327 KNL-PKVHNVNY-PV-LVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ K ++ P+ LVPNL G A +C + EVA + SE + N+N + ++ L
Sbjct: 68 STVCAKYQEADFVPLALVPNLVGAKNAYRCGIREVAYVISASEKHNLANINRTRDQSL 125
>UniRef50_Q8ELJ7 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Oceanobacillus iheyensis|Rep: Hydroxymethylglutaryl-CoA
lyase - Oceanobacillus iheyensis
Length = 318
Score = 85.4 bits (202), Expect = 7e-16
Identities = 41/119 (34%), Positives = 66/119 (55%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
I EV PRDG Q E +++PTD K+E+I L + G+ +E SFV PK + Q+ D EV+
Sbjct: 14 ICEVAPRDGFQAEPEWIPTDKKVEMIRSLAKTGITTMEVTSFVHPKAIPQLKDAEEVVSR 73
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
+ + N++ LVPNL G A V+++ + + ++ S N N +V E + +
Sbjct: 74 VHDIENLHLRALVPNLTGAQRAVNAGVKKLKLMLSATDSHSLSNANATVIEAQNKLEPI 132
>UniRef50_Q9F132 Cluster: Putative uncharacterized protein xlnI;
n=1; Pseudomonas alcaligenes|Rep: Putative
uncharacterized protein xlnI - Pseudomonas alcaligenes
Length = 305
Score = 85.4 bits (202), Expect = 7e-16
Identities = 44/117 (37%), Positives = 69/117 (58%)
Frame = +3
Query: 141 PDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVE 320
P I + EV PRDG Q+ + + T KI +I LV AG K +E SFV+PK + QM+D
Sbjct: 5 PTIEVVEVSPRDGFQSICEPIETQKKISIIEDLVSAGCKRVEIGSFVNPKAVPQMADTSL 64
Query: 321 VMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ ++ + LVPNLKG+ A + +V+E+A + S+ +QKN+ CS ++ +
Sbjct: 65 IAQHFGGRKDFRALALVPNLKGFERALENDVKEMAYVFSASDTHNQKNVGCSTKDSI 121
>UniRef50_Q5SI54 Cluster: Hydroxymethylglutaryl-CoA lyase like
protein; n=2; Thermus thermophilus|Rep:
Hydroxymethylglutaryl-CoA lyase like protein - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 286
Score = 85.0 bits (201), Expect = 9e-16
Identities = 44/106 (41%), Positives = 63/106 (59%), Gaps = 1/106 (0%)
Frame = +3
Query: 168 PRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKNLPKVH 347
PRD Q S+F+PT+ K+ +N+L++AG +++ SFVSPKW+ QM D EV+K LP +
Sbjct: 11 PRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAEEVLKALPPPN 70
Query: 348 NVNYPVLVPNLKGYSIAKQC-NVEEVAIFPAGSEGFSQKNLNCSVE 482
Y +V N KG A N+ V + SE F Q+N N S+E
Sbjct: 71 GRTYLAIVANEKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIE 116
>UniRef50_A7D6W3 Cluster: Pyruvate carboxyltransferase; n=1;
Halorubrum lacusprofundi ATCC 49239|Rep: Pyruvate
carboxyltransferase - Halorubrum lacusprofundi ATCC
49239
Length = 314
Score = 85.0 bits (201), Expect = 9e-16
Identities = 44/114 (38%), Positives = 64/114 (56%)
Frame = +3
Query: 144 DIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEV 323
D+ + E+ PRDG Q +FVPTD K+E+I+ L + G+ IE SF PK + + D EV
Sbjct: 7 DVTLVEMLPRDGFQRLDEFVPTDEKVEIIDALSETGVDEIEITSFTHPKAVPTLRDADEV 66
Query: 324 MKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
+ + + +V Y LVPN G A V++V SE +S+ N N +VEE
Sbjct: 67 AQRIERHDDVTYRALVPNAVGMERAIDAGVDKVNALVTVSETYSEHNQNMTVEE 120
>UniRef50_Q1YPG1 Cluster: Hydroxymethylglutaryl-CoA lyase; n=2;
unclassified Gammaproteobacteria (miscellaneous)|Rep:
Hydroxymethylglutaryl-CoA lyase - gamma proteobacterium
HTCC2207
Length = 304
Score = 83.8 bits (198), Expect = 2e-15
Identities = 41/112 (36%), Positives = 67/112 (59%), Gaps = 1/112 (0%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
I +VGPRDGLQN+ + + + +++L+N + G+ IE SFVSPK + M+ +V
Sbjct: 7 ITDVGPRDGLQNQPQVLSVEQRLQLVNAIADCGVPQIEVGSFVSPKAVPAMAGTGQVFSA 66
Query: 333 LPKVHNVNYPV-LVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
L V + L+PN+KGY +A++ V+ V + S+G +QKN+ S+ E
Sbjct: 67 LDAAEFVTPTIALIPNMKGYELARESGVKTVTMVVYASDGMAQKNVGMSMAE 118
>UniRef50_Q1EXX3 Cluster: Pyruvate carboxyltransferase; n=1;
Clostridium oremlandii OhILAs|Rep: Pyruvate
carboxyltransferase - Clostridium oremlandii OhILAs
Length = 306
Score = 83.8 bits (198), Expect = 2e-15
Identities = 43/121 (35%), Positives = 68/121 (56%), Gaps = 3/121 (2%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I EV PRDG QN F+ T+ KI ++ +L+ A K IE SFVSPK + QM+D EV+
Sbjct: 7 VEILEVCPRDGFQNVKDFIATEDKIAIVERLIDANFKRIELGSFVSPKAIPQMADTKEVV 66
Query: 327 ---KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRR 497
K ++ + LVPN +G A V+++ + SE ++ N+N +V E + +
Sbjct: 67 AAAKQYAVDQDIKFVALVPNARGVESAIAAGVDQITYVISASESHNKANVNRTVAESMEQ 126
Query: 498 F 500
+
Sbjct: 127 Y 127
>UniRef50_Q5KLA2 Cluster: Putative uncharacterized protein; n=1;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 529
Score = 70.1 bits (164), Expect(2) = 2e-15
Identities = 32/65 (49%), Positives = 48/65 (73%), Gaps = 1/65 (1%)
Frame = +3
Query: 147 IRIYEVGPRDGLQN-ESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEV 323
+RI +V PRDGLQN + K VPT++K EL+ +L++AG++NIE SFV W+ QM+D ++
Sbjct: 167 VRIVDVSPRDGLQNLKGKPVPTEVKRELVERLLEAGVRNIEVGSFVRSDWVPQMADTPQL 226
Query: 324 MKNLP 338
+ LP
Sbjct: 227 LPLLP 231
Score = 33.9 bits (74), Expect(2) = 2e-15
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 11/63 (17%)
Frame = +3
Query: 336 PKVHNVNYPVLVPNLKGY-----------SIAKQCNVEEVAIFPAGSEGFSQKNLNCSVE 482
P +V+YPVLVPN++G S +E+A+F + +E FSQ N + +
Sbjct: 270 PHAEDVHYPVLVPNMRGLDNLIKLQEEWSSKGLPALTDEIAVFVSATEAFSQANNHAPIS 329
Query: 483 EGL 491
+ L
Sbjct: 330 KVL 332
>UniRef50_UPI000050F9CC Cluster: COG0119:
Isopropylmalate/homocitrate/citramalate synthases; n=1;
Brevibacterium linens BL2|Rep: COG0119:
Isopropylmalate/homocitrate/citramalate synthases -
Brevibacterium linens BL2
Length = 337
Score = 83.4 bits (197), Expect = 3e-15
Identities = 47/124 (37%), Positives = 69/124 (55%), Gaps = 2/124 (1%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I + RDGLQ E VPTD K+ L +L+ AGLK IE SFV+PK + QM+D EV+
Sbjct: 38 VTILDTTLRDGLQIEDAIVPTDAKVALGEQLIAAGLKEIEVGSFVNPKKVPQMADTGEVL 97
Query: 327 KNLP--KVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRF 500
+ L + V++ LV NLKG A + + + + SEG SQ N + + + +R
Sbjct: 98 QRLQSHEAEGVDFFTLVFNLKGAQRAVDAGAKNIKLVLSASEGHSQANSDAPIAQATQRL 157
Query: 501 TDVA 512
+ A
Sbjct: 158 LEAA 161
>UniRef50_A1WEM7 Cluster: Pyruvate carboxyltransferase; n=2;
Comamonadaceae|Rep: Pyruvate carboxyltransferase -
Verminephrobacter eiseniae (strain EF01-2)
Length = 332
Score = 82.6 bits (195), Expect = 5e-15
Identities = 44/122 (36%), Positives = 68/122 (55%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
I ++EVG RDGLQ E+ FVPTD KI LI+ L AG++ IE+ +FVSP+ + + D V+
Sbjct: 15 IALHEVGMRDGLQAETAFVPTDEKIALIDALADAGMRKIEATAFVSPQAIPALRDASAVL 74
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
+ + + V Y LVPN G A +E+ + + SE + NL + + +
Sbjct: 75 RAIGRRPGVIYSALVPNAGGAERAIDAGADELNLVMSASESHNLANLKMTRAQSFEALSG 134
Query: 507 VA 512
V+
Sbjct: 135 VS 136
>UniRef50_UPI000050F830 Cluster: COG0119:
Isopropylmalate/homocitrate/citramalate synthases; n=1;
Brevibacterium linens BL2|Rep: COG0119:
Isopropylmalate/homocitrate/citramalate synthases -
Brevibacterium linens BL2
Length = 311
Score = 82.2 bits (194), Expect = 6e-15
Identities = 40/120 (33%), Positives = 68/120 (56%)
Frame = +3
Query: 150 RIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMK 329
R+ EVG RDGLQ + TD KI ++++++ AG K IE ASF PK + Q++D V+
Sbjct: 9 RVVEVGLRDGLQAIDTPLSTDRKIAIVSEMIAAGFKEIEVASFAHPKVLPQLADAEAVLA 68
Query: 330 NLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
+P+ +V + LVPN +G A +C ++E+ +G + KN + + L + ++
Sbjct: 69 GIPRPPDVRFRALVPNARGALRAAKCELDELTFVVPAEDGMALKNQGTTTDGLLDQLDEI 128
>UniRef50_A3WDQ0 Cluster: 3-hydroxy-3-methylglutarate-CoA lyase;
n=2; Sphingomonadales|Rep:
3-hydroxy-3-methylglutarate-CoA lyase - Erythrobacter
sp. NAP1
Length = 309
Score = 79.8 bits (188), Expect = 3e-14
Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 6/131 (4%)
Frame = +3
Query: 135 SVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDG 314
S P I + EVGPRDGLQNE + VPT K++LIN ++ G + +E ASFV P + QM+D
Sbjct: 9 SAPAIELVEVGPRDGLQNEPETVPTATKLDLINAMINYGARRLEVASFVHPNRVPQMADA 68
Query: 315 VEVMKNLPKVHNVNYPVLVPNLKGY--SIAK----QCNVEEVAIFPAGSEGFSQKNLNCS 476
V++ LP +V + L N +G +A + +++ S+ F KN +
Sbjct: 69 EAVIEALPDRGDVTFIGLTLNKRGIMRGLATREGGRRGIDQAGCVIVASDTFGIKNQGQT 128
Query: 477 VEEGLRRFTDV 509
++EG+ D+
Sbjct: 129 IDEGIAENRDM 139
>UniRef50_A1W9T7 Cluster: Pyruvate carboxyltransferase; n=34;
Proteobacteria|Rep: Pyruvate carboxyltransferase -
Acidovorax sp. (strain JS42)
Length = 327
Score = 79.4 bits (187), Expect = 4e-14
Identities = 43/107 (40%), Positives = 61/107 (57%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
I + +VG RDGLQ E++FVPT+ KI L+N L AGL IE SF SP + + D VM
Sbjct: 13 IALCDVGLRDGLQMEAQFVPTEDKIALVNALSHAGLSKIEVTSFTSPTAIPALRDAEVVM 72
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNL 467
+ + + V Y LVPN +G A + +E+ + + SE + NL
Sbjct: 73 REIERRPGVTYTALVPNARGAERAIESRTDELNLVMSVSETHNLANL 119
>UniRef50_Q0S6H7 Cluster: Possible hydroxymethylglutaryl-CoA lyase;
n=2; Actinomycetales|Rep: Possible
hydroxymethylglutaryl-CoA lyase - Rhodococcus sp.
(strain RHA1)
Length = 289
Score = 78.2 bits (184), Expect = 1e-13
Identities = 45/116 (38%), Positives = 67/116 (57%), Gaps = 1/116 (0%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I +V RDGLQ+E V TD KI + + LV AG+K+IE+ASFVSP + QM+D +V+
Sbjct: 3 VTITDVVLRDGLQDEDVVVSTDHKIVVADALVAAGVKHIEAASFVSPTRVPQMADADDVI 62
Query: 327 KNLPKVH-NVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
LP+ +V Y L N +G A ++E+ + + S G S N + +E L
Sbjct: 63 ARLPRTDPSVTYSALALNPRGVHRAIATGIDEIQVVTSASAGHSTANTGRNPDEAL 118
>UniRef50_Q5WKL8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Bacillus clausii KSM-K16|Rep: Hydroxymethylglutaryl-CoA
lyase - Bacillus clausii (strain KSM-K16)
Length = 309
Score = 74.9 bits (176), Expect = 1e-12
Identities = 41/115 (35%), Positives = 65/115 (56%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I EVGPRDGLQNE + + KIE++ ++G+ IE+ SFV+ K + M+D EVM
Sbjct: 13 VEICEVGPRDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVSFVNKKLVPAMADAEEVM 72
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ V L + G + A Q ++ + I + S+ F+++N N +V EGL
Sbjct: 73 AAWHRREGVRIAGLALSRSGITRALQTPIDVLHITISASDAFNKRNANKTVAEGL 127
>UniRef50_Q9AAX5 Cluster: 3-hydroxy-3-methylglutarate-CoA lyase;
n=5; Alphaproteobacteria|Rep:
3-hydroxy-3-methylglutarate-CoA lyase - Caulobacter
crescentus (Caulobacter vibrioides)
Length = 299
Score = 74.5 bits (175), Expect = 1e-12
Identities = 40/113 (35%), Positives = 62/113 (54%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
I+I EVGPRDGLQNE + + K++LI KL AG + E SFV+P + QM+ E+M
Sbjct: 5 IQIVEVGPRDGLQNEKTVLSVEEKLDLIAKLEAAGARRTEVVSFVNPSRVPQMAGAEEIM 64
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
LP + LV N++G+ +E + S+GF+ +N + ++
Sbjct: 65 AALPADLVHSRIGLVLNMRGWERCVSTGCDEANVVVCASDGFATRNQGSTTQQ 117
>UniRef50_A3JDD8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=2;
Proteobacteria|Rep: Hydroxymethylglutaryl-CoA lyase -
Marinobacter sp. ELB17
Length = 312
Score = 74.1 bits (174), Expect = 2e-12
Identities = 41/122 (33%), Positives = 64/122 (52%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I EV PRDG Q+ + +PT KI+ + L+ +G+ IE SFVS K + QM+D ++
Sbjct: 11 VDIVEVAPRDGFQSIHELLPTAGKIQCVQALIDSGITRIEIGSFVSSKAIPQMADIGNIV 70
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
+ + LVPNLKG A ++E+ + SE +Q N+ SV+ L
Sbjct: 71 AAFSDHTGMRFSALVPNLKGADRALASGIKELVFVVSVSETHNQSNVRQSVDSSLDGLKT 130
Query: 507 VA 512
+A
Sbjct: 131 IA 132
>UniRef50_Q89GI1 Cluster: Bll6364 protein; n=1; Bradyrhizobium
japonicum|Rep: Bll6364 protein - Bradyrhizobium
japonicum
Length = 311
Score = 73.3 bits (172), Expect = 3e-12
Identities = 41/119 (34%), Positives = 59/119 (49%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
+ EVGPRDGLQ +PT+ K+ ++V AG+ IE SFV PK + Q D EV +
Sbjct: 7 VREVGPRDGLQMVGTILPTERKLAWCRRVVAAGIHEIEVTSFVPPKLIPQFGDAEEVARG 66
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
+ LVPNL+G A V +V + SE + N+ + E+ L F +
Sbjct: 67 AMAIAGCRPSALVPNLRGAERAFALGVPQVNYVLSASEQHNLANVRRTTEQSLEDFARI 125
>UniRef50_Q120B4 Cluster: Pyruvate carboxyltransferase; n=3;
Proteobacteria|Rep: Pyruvate carboxyltransferase -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 317
Score = 72.5 bits (170), Expect = 5e-12
Identities = 45/125 (36%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
MS + +E GPR+G Q E K + LI+ L +GLK I+ ASFVSP+ + QM
Sbjct: 1 MSKLPTSVEFHEEGPREGFQMEPKTYSLADRAALIDALAASGLKQIQVASFVSPRAVPQM 60
Query: 306 SDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEV--AIFPAGSEGFSQKNLNCSV 479
+D E+ + K Y L N G+ A+ C ++ + +E FSQ+N NCSV
Sbjct: 61 ADTAELFAAIAKRPGTRYTALWLNDNGFDRARACEQVDLDGKLMFYTTEPFSQRNNNCSV 120
Query: 480 EEGLR 494
G+R
Sbjct: 121 -AGMR 124
>UniRef50_Q122Z2 Cluster: Pyruvate carboxyltransferase; n=64;
Proteobacteria|Rep: Pyruvate carboxyltransferase -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 729
Score = 72.1 bits (169), Expect = 7e-12
Identities = 40/113 (35%), Positives = 63/113 (55%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I EVGPRDGLQ+ +PT K+ I+ L +AG++ IE ASFV + + QM+D EV+
Sbjct: 10 VLISEVGPRDGLQSVKATMPTADKLRWIDALYKAGVREIEVASFVPARLLPQMADAAEVV 69
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
++ + + LVPN +G A V ++ + + S S N+ + EE
Sbjct: 70 RHAITLPGLTVMALVPNRRGAEAALAAGVHKLTMPVSASAAHSLANVRKTREE 122
>UniRef50_A5P2D8 Cluster: Hydroxymethylglutaryl-CoA lyase; n=3;
Alphaproteobacteria|Rep: Hydroxymethylglutaryl-CoA lyase
- Methylobacterium sp. 4-46
Length = 308
Score = 71.3 bits (167), Expect = 1e-11
Identities = 41/113 (36%), Positives = 59/113 (52%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I EVGPRDG Q F+PT+ KIE++ +LV AGL+ IE SFVS + QM D EV+
Sbjct: 6 VEIVEVGPRDGYQGIGPFIPTERKIEILGRLVAAGLRRIEIGSFVSATALPQMRDTPEVL 65
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
+ + VLVP+ + A + + SE ++ N+ S E
Sbjct: 66 AACARFPGLEPQVLVPSERRGRDAVAAGARRLVFVLSVSEAHNRNNVRRSPGE 118
>UniRef50_A6EGU7 Cluster: Hydroxymethylglutaryl-CoA lyase like
protein; n=1; Pedobacter sp. BAL39|Rep:
Hydroxymethylglutaryl-CoA lyase like protein -
Pedobacter sp. BAL39
Length = 303
Score = 70.9 bits (166), Expect = 2e-11
Identities = 45/122 (36%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
Frame = +3
Query: 129 STSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMS 308
S P ++I E PRD +Q F+ TDIK+ +NKL++ G I+ SFVSPK + Q+
Sbjct: 14 SAENPAVKIIEC-PRDAMQGIHNFIDTDIKVAYLNKLLKVGFDTIDFGSFVSPKAIPQLR 72
Query: 309 DGVEVMKNLPKVHNVNYPVL--VPNLKGYSIAKQCNVEEVAIFPAG-SEGFSQKNLNCSV 479
D EV+ L ++++ + +L V NLKG A FP SE F Q+N N S+
Sbjct: 73 DTAEVLSKL-ELNDTSSKLLAIVANLKGVQEAATHQEITYLGFPFSISETFQQRNTNASI 131
Query: 480 EE 485
+
Sbjct: 132 TQ 133
>UniRef50_Q0FWC0 Cluster: Putative hydroxymethylglutaryl-CoA lyase;
n=1; Roseovarius sp. HTCC2601|Rep: Putative
hydroxymethylglutaryl-CoA lyase - Roseovarius sp.
HTCC2601
Length = 337
Score = 70.5 bits (165), Expect = 2e-11
Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
MS + I E G R+G Q+E +PT KI LI L + G+ I+ ASFV+PK + QM
Sbjct: 25 MSELPSKVHIVEEGAREGFQSEPAGIPTSEKIRLIEALAETGVPEIDCASFVNPKVVPQM 84
Query: 306 SDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFP-AGSEGFSQKNLNCSVE 482
+D ++ + + K V Y + N KG+ A + + A+ + S+ F +N N + E
Sbjct: 85 ADVAQIAEGIRKREGVTYGCMWLNAKGFLQAAESGLSLPALTSGSASDTFLARNNNATPE 144
Query: 483 EGL 491
+ L
Sbjct: 145 KQL 147
>UniRef50_Q5ARE9 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 408
Score = 68.5 bits (160), Expect = 8e-11
Identities = 31/57 (54%), Positives = 41/57 (71%)
Frame = +3
Query: 141 PDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSD 311
P + I EV PRDGLQN +F+PT+IK+ LI +L GL+ IE AS VSPK + Q++D
Sbjct: 35 PQVHIVEVSPRDGLQNIPEFIPTEIKVALIRRLAGTGLQTIEIASVVSPKVVPQLAD 91
Score = 44.8 bits (101), Expect = 0.001
Identities = 20/54 (37%), Positives = 35/54 (64%), Gaps = 4/54 (7%)
Frame = +3
Query: 360 PVLVPNLKGYSI----AKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
P+L+PNLKG S+ + + + + +F + + FS +N+NCSV++GL R +V
Sbjct: 153 PILLPNLKGLSLLLSHSPRPPIRSICVFISATAPFSHRNINCSVDDGLLRAREV 206
>UniRef50_A3I2Z1 Cluster: Hydroxymethylglutaryl-CoA lyase like
protein; n=2; Flexibacteraceae|Rep:
Hydroxymethylglutaryl-CoA lyase like protein -
Algoriphagus sp. PR1
Length = 284
Score = 67.7 bits (158), Expect = 1e-10
Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 3/117 (2%)
Frame = +3
Query: 168 PRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKNLPKVH 347
PRD +Q F+ T +K IN+L++ G I+ SFVSPK + Q+ D EV+ L +H
Sbjct: 8 PRDAMQGIPHFIDTAVKAAYINQLLEIGFDTIDFGSFVSPKAVPQLRDTEEVL-GLLDLH 66
Query: 348 NVNYPVL--VPNLKGYSIAKQCNVEEVAIFPAG-SEGFSQKNLNCSVEEGLRRFTDV 509
+ +L V NL+G A + + FP SE F QKN N S+ E L+ ++
Sbjct: 67 HAKSKLLAIVANLRGAEDASHFDEIDYLGFPLSVSETFQQKNTNRSISEALKTVEEI 123
>UniRef50_Q1IRS1 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Acidobacteria bacterium Ellin345|Rep:
Hydroxymethylglutaryl-CoA lyase - Acidobacteria
bacterium (strain Ellin345)
Length = 290
Score = 67.3 bits (157), Expect = 2e-10
Identities = 41/114 (35%), Positives = 63/114 (55%), Gaps = 1/114 (0%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I E PRD Q +PT++K++ + +LV AG K+I++ SFVSP+ + QM+D EV+
Sbjct: 5 VKIIEC-PRDAWQGLKGQIPTELKVKYLQELVSAGFKHIDAVSFVSPRAVPQMADSEEVL 63
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFP-AGSEGFSQKNLNCSVEE 485
K L +V +V N KG A FP + S F + N N ++EE
Sbjct: 64 KELDPPDDVEIIGIVVNEKGADRAIATEAVRTLGFPYSFSPTFLKNNQNQTLEE 117
>UniRef50_Q7VSS8 Cluster: Putative hydroxymethylglutaryl-CoA lyase;
n=5; Proteobacteria|Rep: Putative
hydroxymethylglutaryl-CoA lyase - Bordetella pertussis
Length = 335
Score = 66.5 bits (155), Expect = 3e-10
Identities = 38/119 (31%), Positives = 60/119 (50%), Gaps = 2/119 (1%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ +E GPR+G Q+E P ++ L++ L GLK I+ ASFV+P+ + M+D E+
Sbjct: 15 VEFHEEGPREGFQSEKTLYPLASRVALVDALTATGLKKIQVASFVNPRMVPAMADAAELF 74
Query: 327 KNLPKVHNVNYPVLVPNLKGY-SIAKQCNVE-EVAIFPAGSEGFSQKNLNCSVEEGLRR 497
+ K V + L N KG A V+ + + SE FS N CS ++ +R
Sbjct: 75 GAIRKKSGVRHTALWLNAKGIEKAAATAGVDLDGKMMLYASEAFSWSNNGCSAKDQQQR 133
>UniRef50_UPI0000510140 Cluster: COG0119:
Isopropylmalate/homocitrate/citramalate synthases; n=1;
Brevibacterium linens BL2|Rep: COG0119:
Isopropylmalate/homocitrate/citramalate synthases -
Brevibacterium linens BL2
Length = 314
Score = 62.5 bits (145), Expect = 5e-09
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 5/127 (3%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
+ I E RDGLQ+E++FV T K+ + V+ G K IE+ S+ P + +D +++
Sbjct: 5 VSINECFARDGLQHETEFVATRDKLAALESFVRVGFKRIEATSYSHPAQVPAFTDASDLL 64
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIA-----KQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
LP+ + PN + A VEE+++ + SE SQ NL + E
Sbjct: 65 LKLPRPEGTAFKATCPNQRAVQRALADHDAGIGVEEISLLTSASESHSQVNLRATRNEQW 124
Query: 492 RRFTDVA 512
+ ++A
Sbjct: 125 HKVEEMA 131
>UniRef50_A1UDB1 Cluster: Pyruvate carboxyltransferase; n=6;
Actinomycetales|Rep: Pyruvate carboxyltransferase -
Mycobacterium sp. (strain KMS)
Length = 301
Score = 60.9 bits (141), Expect = 2e-08
Identities = 35/128 (27%), Positives = 61/128 (47%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
MS + I EV RDGLQ E +P K+EL+ +V G++ +E+ +FVSP + +
Sbjct: 1 MSDLPAKVDIREVSLRDGLQIEQP-IPLSAKLELLEAVVATGVREVEATAFVSPSKVPAL 59
Query: 306 SDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
+D E+ L + V + LV + G A + + + ++ S+ N+ S E
Sbjct: 60 ADAAELAAELGRFDQVEFSALVASPNGAKRAIAAGLRSIEYVVSAADSHSRANVGRSSME 119
Query: 486 GLRRFTDV 509
+ D+
Sbjct: 120 SVAAIPDI 127
>UniRef50_Q4AH02 Cluster: Hydroxymethylglutaryl-CoA lyase; n=1;
Chlorobium phaeobacteroides BS1|Rep:
Hydroxymethylglutaryl-CoA lyase - Chlorobium
phaeobacteroides BS1
Length = 282
Score = 58.4 bits (135), Expect = 9e-08
Identities = 36/113 (31%), Positives = 62/113 (54%), Gaps = 2/113 (1%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
I+I E PRDG Q + +PT K++ IN+L++ G + +E SFVSP+ + QM+D +V+
Sbjct: 5 IKIIET-PRDGFQALNGIIPTSDKVKYINQLLRCGFQTVEVGSFVSPRLIPQMADTADVL 63
Query: 327 KNLP-KVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFP-AGSEGFSQKNLNCSV 479
+ L + + VL KG +A + FP + S F ++N+ ++
Sbjct: 64 RQLDLQDVTSDIAVLAVTEKGGQMACDFKQVDQVFFPFSTSPTFLRRNIKSTL 116
>UniRef50_Q583A8 Cluster: 3-hydroxy-3-methylglutaryl-CoA lyase,
putative; n=4; Trypanosoma|Rep:
3-hydroxy-3-methylglutaryl-CoA lyase, putative -
Trypanosoma brucei
Length = 431
Score = 58.0 bits (134), Expect = 1e-07
Identities = 40/127 (31%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
IR+ E PRD +Q F+PT+ KI + L++ G ++ SFVSP+ + QM D EV+
Sbjct: 11 IRMVEC-PRDAMQGLPHFIPTEQKIRYLKALLKCGFYALDCGSFVSPRAVPQMRDSTEVI 69
Query: 327 KNLPKVHN-----VNYPVLVPNLKGYSIAKQCNVEEVAIFPAG-SEGFSQKNLNCSVEEG 488
N K V+V +L G+ A + V +P G E F Q+N S+
Sbjct: 70 ANCWKTMQEEKAAPKLSVVVASLAGFKQALETPGVSVIGYPIGCCERFQQRNAKKSIAMS 129
Query: 489 LRRFTDV 509
L ++
Sbjct: 130 LDEIRNI 136
>UniRef50_Q4AF29 Cluster: HMG-CoA lyase-like; n=1; Chlorobium
phaeobacteroides BS1|Rep: HMG-CoA lyase-like -
Chlorobium phaeobacteroides BS1
Length = 336
Score = 57.2 bits (132), Expect = 2e-07
Identities = 32/100 (32%), Positives = 59/100 (59%)
Frame = +3
Query: 153 IYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN 332
I ++ RDG Q+E K+VPT+ K+ ++ +L+ AG+K++E +F +PK M Q D ++ K
Sbjct: 9 IGDITVRDGFQHEEKYVPTEAKLWVLEELILAGVKHLEVTNFGNPKGMPQFKDADKLFKG 68
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGF 452
+ V++ L+P++ ++ + E AI A EG+
Sbjct: 69 IRNSKRVSH--LLPDVSLTAVTIRERAIERAI-EAKKEGY 105
>UniRef50_A1T6B5 Cluster: Pyruvate carboxyltransferase; n=6;
Mycobacterium|Rep: Pyruvate carboxyltransferase -
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Length = 301
Score = 55.2 bits (127), Expect = 8e-07
Identities = 31/128 (24%), Positives = 61/128 (47%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
MS + I +V RDGLQ E +P K+EL+ + G++ +E+ +FVSP + +
Sbjct: 1 MSELPGHVDIRDVSLRDGLQIEDP-IPLSAKLELLAAIAATGVREMEATAFVSPSKVPAL 59
Query: 306 SDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
+D ++ L ++ + LV + G A + + + ++G S+ N+ S E
Sbjct: 60 ADAADLAAELRNFPDIEFSALVASPNGAKRAIAAGLRSIEYVVSAADGHSRANVGRSSAE 119
Query: 486 GLRRFTDV 509
+ ++
Sbjct: 120 ATAQIPEI 127
>UniRef50_Q89WI9 Cluster: Blr0698 protein; n=1; Bradyrhizobium
japonicum|Rep: Blr0698 protein - Bradyrhizobium
japonicum
Length = 315
Score = 53.2 bits (122), Expect = 3e-06
Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQ---MSDGV 317
+ + EVG RDGLQ KF T+ K + + AG+++ E SF+ K Q + D +
Sbjct: 13 VSLREVGLRDGLQLVKKFPSTEAKQRWVREEYAAGVRHFEVGSFLPAKTFPQFVDVRDVI 72
Query: 318 EVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ NLP H + L N +G + A + V E+A + +E SQ N + S + +
Sbjct: 73 GAVANLPGAHGI---ALALNERGVNEALESGVGEIASVVSATEEHSQANAHRSRDSAI 127
>UniRef50_A4C110 Cluster: Hydroxymethylglutaryl-CoA lyase like
protein; n=15; Bacteroidetes|Rep:
Hydroxymethylglutaryl-CoA lyase like protein -
Polaribacter irgensii 23-P
Length = 290
Score = 52.4 bits (120), Expect = 6e-06
Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
Frame = +3
Query: 147 IRIYEVGPRDGLQN-ESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEV 323
++I E PRD +Q +S F+ T+ K IN L+ G I+ SFVSPK + QM D V
Sbjct: 4 VKIIEC-PRDAMQGIKSHFISTEKKALYINALLTVGFDTIDFGSFVSPKAIPQMRDTAAV 62
Query: 324 MKNLP-KVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAG-SEGFSQKNLNCSVEEGLRR 497
+ L ++ N++G A Q +P SE F +N + ++ E +
Sbjct: 63 LSKLELSTTESKLLAIIANVRGAEQAAQFEEINYLGYPFSISENFQMRNTHKTIAESIAA 122
Query: 498 FTDV 509
++
Sbjct: 123 LDEI 126
>UniRef50_Q0S6Y1 Cluster: Hydroxymethylglutaryl-CoA lyase; n=5;
Actinomycetales|Rep: Hydroxymethylglutaryl-CoA lyase -
Rhodococcus sp. (strain RHA1)
Length = 312
Score = 45.2 bits (102), Expect = 9e-04
Identities = 31/111 (27%), Positives = 49/111 (44%)
Frame = +3
Query: 159 EVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKNLP 338
+V RDGLQ K +PT K+E+ +L + G+ +E S P + M++ VEV+ L
Sbjct: 13 DVTLRDGLQLTGKMLPTARKLEIARRLFELGVPALEIGSMARPDLVPPMANTVEVISELT 72
Query: 339 KVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGL 491
+ V V + A + S+ +Q N+ S EE L
Sbjct: 73 PDELDHCWVWVATPRHVEKAAAAGARHFQYCFSASDSHNQANIGRSTEESL 123
>UniRef50_Q4MV51 Cluster: YngK protein; n=15; Bacillus|Rep: YngK
protein - Bacillus cereus G9241
Length = 638
Score = 37.5 bits (83), Expect = 0.18
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Frame = +3
Query: 222 ELINKL-VQAGLKNIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIA 398
E+IN+L + + L NIE + F S K +KQ G+ K + + YP LVPN+ +
Sbjct: 311 EIINQLALNSTLSNIEGSIFFSYKDLKQDKLGI---KERLRANAYKYPALVPNMPWLDNS 367
Query: 399 KQCNVEEVAIFPAGSEGFSQKNLNCSVE 482
N E+++ + +N N E
Sbjct: 368 APSNPSEISVTDGPNGATISRNNNAGKE 395
>UniRef50_A6R9V0 Cluster: Putative uncharacterized protein; n=4;
Eurotiomycetidae|Rep: Putative uncharacterized protein -
Ajellomyces capsulatus NAm1
Length = 433
Score = 36.7 bits (81), Expect = 0.31
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 20/83 (24%)
Frame = +3
Query: 321 VMKNLPKV-HNVNYPVLVPNLKGY--------------SIAKQCNV-----EEVAIFPAG 440
++K PK H++ Y LVPN+KG S + N E+++F A
Sbjct: 48 LLKTPPKSSHSIAYNYLVPNIKGLQNLVNIMDNDSPPASESSDSNTLPKPTTEISLFAAA 107
Query: 441 SEGFSQKNLNCSVEEGLRRFTDV 509
+E FS+ N NC++EE L R +
Sbjct: 108 TEAFSKANTNCTIEESLERIRPI 130
>UniRef50_Q6KH81 Cluster: Mg-dependent DNAse; n=1; Mycoplasma
mobile|Rep: Mg-dependent DNAse - Mycoplasma mobile
Length = 261
Score = 35.5 bits (78), Expect = 0.72
Identities = 39/155 (25%), Positives = 62/155 (40%), Gaps = 3/155 (1%)
Frame = +3
Query: 57 LTMKQYTRIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINK 236
L ++ R + L ++I + HM S+ D+ YE+ + +N T K
Sbjct: 106 LQIETLKRFLRLSISKNIPTMIHMRNSIEDM--YEIFSQKEFKNHRIVFHTYSGNAFWAK 163
Query: 237 LVQAGLKNIESASFVSPKWMKQMSDGVEVMKNLPKVH---NVNYPVLVPNLKGYSIAKQC 407
NI SF K D VE +K +P + P L P + K
Sbjct: 164 KFLDLNPNIYF-SFSGVATFKNAKDTVEAIKEIPVERIFVETDAPFLTPVPYRGTKNKPV 222
Query: 408 NVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTDVA 512
V+EVA F A + + +N N V E + RF +++
Sbjct: 223 YVKEVAKFVASLKKLNVENFNIKVNENIERFFNLS 257
>UniRef50_Q57926 Cluster: 2-isopropylmalate synthase 1; n=10;
Euryarchaeota|Rep: 2-isopropylmalate synthase 1 -
Methanococcus jannaschii
Length = 398
Score = 34.3 bits (75), Expect = 1.7
Identities = 38/122 (31%), Positives = 59/122 (48%), Gaps = 6/122 (4%)
Frame = +3
Query: 144 DIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEV 323
DI IY+ RDG Q + K+E+ KL + GLK IE A F P ++ +D V+
Sbjct: 23 DIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIE-AGF--PIVSEREADIVKT 79
Query: 324 MKNLPKVHNVNYPVLVPNL-KGYSIAKQCNVEEVAIFPAGSE-----GFSQKNLNCSVEE 485
+ N + N + L L K A +C+V+ + F A S F+ K+L+ +E
Sbjct: 80 IAN--EGLNADILALCRALKKDIDKAIECDVDGIITFIATSPLHLKYKFNNKSLDEILEM 137
Query: 486 GL 491
G+
Sbjct: 138 GV 139
>UniRef50_Q21604 Cluster: Putative uncharacterized protein pan-1;
n=3; Caenorhabditis|Rep: Putative uncharacterized
protein pan-1 - Caenorhabditis elegans
Length = 610
Score = 33.9 bits (74), Expect = 2.2
Identities = 16/61 (26%), Positives = 31/61 (50%)
Frame = +3
Query: 84 ISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNI 263
I + A + ++ + + DIR+ + G DG++N K + +E+I K GL ++
Sbjct: 166 IDVGAFEELKKVEELLLNENDIRVLKTGTFDGMKNLKKLTLQNCNLEIIQKGAFRGLNSL 225
Query: 264 E 266
E
Sbjct: 226 E 226
>UniRef50_A6LNL7 Cluster: Putative uncharacterized protein; n=1;
Thermosipho melanesiensis BI429|Rep: Putative
uncharacterized protein - Thermosipho melanesiensis
BI429
Length = 196
Score = 33.5 bits (73), Expect = 2.9
Identities = 27/89 (30%), Positives = 40/89 (44%), Gaps = 8/89 (8%)
Frame = +3
Query: 198 FVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVMKN----LPKVHNVNYPV 365
F+ D K+EL+ Q GLKN + F+S K+ K DG + N L + N P
Sbjct: 14 FLVKDYKLELMKNFEQFGLKNYNFSGFLSKKFFK-AKDGYYLKNNGLLVLKTFNEKNLPE 72
Query: 366 LVPNLKGYS----IAKQCNVEEVAIFPAG 440
+V L + I K+ V+ + F G
Sbjct: 73 VVYKLSKSTFFGIIPKKVEVKPIEFFQEG 101
>UniRef50_Q2UI00 Cluster: Cytochrome P450; n=1; Aspergillus
oryzae|Rep: Cytochrome P450 - Aspergillus oryzae
Length = 527
Score = 32.7 bits (71), Expect = 5.0
Identities = 14/47 (29%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +3
Query: 156 YEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIE-SASFVSPKW 293
Y V P +GLQ + F+P D+ + + +L+Q + + S F+ +W
Sbjct: 378 YRVTPAEGLQIDEVFIPGDVNVFVPQQLIQTDERYYKFSKEFIPERW 424
>UniRef50_Q12W45 Cluster: Putative uncharacterized protein; n=1;
Methanococcoides burtonii DSM 6242|Rep: Putative
uncharacterized protein - Methanococcoides burtonii
(strain DSM 6242)
Length = 233
Score = 32.7 bits (71), Expect = 5.0
Identities = 15/25 (60%), Positives = 19/25 (76%)
Frame = +3
Query: 216 KIELINKLVQAGLKNIESASFVSPK 290
K ELINK+V GLKN+ES+ VS +
Sbjct: 34 KDELINKIVHTGLKNMESSIIVSTR 58
>UniRef50_Q1GH47 Cluster: Putative uncharacterized protein; n=1;
Silicibacter sp. TM1040|Rep: Putative uncharacterized
protein - Silicibacter sp. (strain TM1040)
Length = 166
Score = 32.3 bits (70), Expect = 6.7
Identities = 17/47 (36%), Positives = 27/47 (57%)
Frame = +3
Query: 180 LQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVE 320
LQ PTD ++L N +QAGL + +A ++P+ ++S GVE
Sbjct: 120 LQRIDALAPTD-NVDLGNPQIQAGLDLLVAAGLLTPERKAEISSGVE 165
>UniRef50_A7AWL8 Cluster: DnaK family domain containing protein;
n=1; Babesia bovis|Rep: DnaK family domain containing
protein - Babesia bovis
Length = 861
Score = 32.3 bits (70), Expect = 6.7
Identities = 26/96 (27%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Frame = +3
Query: 174 DGLQNESKFVPTDIKIELINKLVQAGLKNIES----ASFVSPKWMKQMSDGVEVM---KN 332
+GL F P + E N L+Q + NIE+ A ++ + DGVE++
Sbjct: 359 EGLIRNVDFTPEQVTKETFNSLIQDSVNNIETTIHEAMELAGGLKMEDLDGVEIIGGASR 418
Query: 333 LPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAG 440
+P V N ++ P G+ + N EE AG
Sbjct: 419 VPAVQNKLVQIVAPQQLGFHL----NAEEAVAVGAG 450
>UniRef50_A2DYI5 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 1087
Score = 32.3 bits (70), Expect = 6.7
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 1/75 (1%)
Frame = +3
Query: 255 KNIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFP 434
KN A+ ++ Q++D + ++ + ++ +PN+ G+ IA N+ + I+
Sbjct: 197 KNCLIATSNGDIYLYQITDKLNLINTVSSNLKISSASWLPNMPGHFIASDPNIGTIRIWS 256
Query: 435 AGSEGFSQK-NLNCS 476
AGSE Q NLN S
Sbjct: 257 AGSEAPIQSFNLNHS 271
>UniRef50_A0D1L9 Cluster: Chromosome undetermined scaffold_34, whole
genome shotgun sequence; n=5; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_34,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 518
Score = 32.3 bits (70), Expect = 6.7
Identities = 16/55 (29%), Positives = 30/55 (54%)
Frame = +3
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEV 422
N+E+ + S K MKQ+ + + N HN N ++ L+G + ++ +VEE+
Sbjct: 316 NLENLIYNSNKHMKQLQTSLAINNNYFGYHNSNLGNMIQKLQGENNQERVDVEEL 370
>UniRef50_A6RYF2 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 865
Score = 32.3 bits (70), Expect = 6.7
Identities = 19/60 (31%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Frame = -3
Query: 277 KLADSIFFNP--AWTNLFISSILISVGTNLDSFWRPSLGPTS*ILMSGTLVLICFKFEID 104
KL++ IF N WT I +++ +G+N +F P L TS +L F F+ D
Sbjct: 521 KLSEYIFSNDITTWTKSLIRTLITKIGSNSHAFATPLLDKTSLLLQYRAAKKRLFMFDYD 580
>UniRef50_P38746 Cluster: Putative GTP-binding protein YLF2; n=4;
Saccharomycetales|Rep: Putative GTP-binding protein YLF2
- Saccharomyces cerevisiae (Baker's yeast)
Length = 405
Score = 32.3 bits (70), Expect = 6.7
Identities = 31/120 (25%), Positives = 53/120 (44%)
Frame = +3
Query: 108 ISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSP 287
I N + TS P + + V P+D ++NE+KFV IE IN+ + SA F S
Sbjct: 213 ILNKHNFLTSKPTLILLNVSPQDYVRNENKFVRN--IIEWINEFSPGDKFLLFSAEFES- 269
Query: 288 KWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNL 467
+ M+ E + + NV+ LV + + + + ++ F G + Q N+
Sbjct: 270 QLMECKGIASEYFDKIKEDTNVSDQQLVSAIPQIILEMRKLLNLISFFTCGPQEVHQWNI 329
>UniRef50_Q5CWG7 Cluster: Ring finger protein; n=3;
Cryptosporidium|Rep: Ring finger protein -
Cryptosporidium parvum Iowa II
Length = 459
Score = 31.9 bits (69), Expect = 8.8
Identities = 15/53 (28%), Positives = 27/53 (50%)
Frame = -2
Query: 290 FWTDKACGFNILQPRLD*FIYKFYFNISGNKFRLVLETISRTHFVNSNVRYTC 132
FWTD N+ QP + I +FY +I N ++ + +H ++N + +C
Sbjct: 71 FWTDNDDQLNLYQPNVSAQIERFYLHIQWNLYK-ESQNDENSHHSHNNCQKSC 122
>UniRef50_A2HDF9 Cluster: Putative uncharacterized protein; n=3;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 83
Score = 31.9 bits (69), Expect = 8.8
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Frame = +3
Query: 111 SNLKHMSTSVPDIRIYEVGPRDGLQ---NESKFVPTDIKIELINKLVQAGL 254
SNLKH T++ R+ R ++ NE F+ T + L+N LV AG+
Sbjct: 7 SNLKHSGTNMYQTRVSNALVRFSIKIFLNEKVFIETRTRASLLNTLVPAGI 57
>UniRef50_A3GHW1 Cluster: Predicted protein; n=2; Pichia|Rep:
Predicted protein - Pichia stipitis (Yeast)
Length = 316
Score = 31.9 bits (69), Expect = 8.8
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Frame = +3
Query: 36 LMQ*S*NLTMK-QYTRIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTD 212
+MQ S N+ + Y + + +KA N+ + +P ++G +E K + T
Sbjct: 220 IMQSSENIWLNIDYLKDLLVKARIVFKNVAYSQCYMPSYTSGQLGLVIATNDEEKTLQTP 279
Query: 213 IKIELINK---LVQAGLKNIESASFVSPKWMKQMSD 311
++ L K + Q I SASFV PKW K D
Sbjct: 280 LRRFLEEKESQIFQYYSLEIHSASFVLPKWAKNKLD 315
>UniRef50_P24795 Cluster: Protein E15; n=1; Enterobacteria phage
D108|Rep: Protein E15 - Bacteriophage D108
Length = 96
Score = 31.9 bits (69), Expect = 8.8
Identities = 23/88 (26%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Frame = +3
Query: 180 LQNESKFVPTDIKIELIN-KLVQAGLKNIESASFVSPKWMKQMSDGVEVMKNLPKVHNVN 356
+ NE+KF P D+ EL+ K+++ IE+A +S + + + +E+M ++H +
Sbjct: 1 MNNETKFTPKDLDEELVKAKMLERMHDVIETA--ISKGFSAR--EALEIMTR--EIHLIR 54
Query: 357 YPVLVPNLKGYS--IAKQCNVEEVAIFP 434
VL+ N K ++ + ++ V++ A+ P
Sbjct: 55 DEVLLHNKKAHNNIVCRELGVDDSAVIP 82
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 432,072,549
Number of Sequences: 1657284
Number of extensions: 7657243
Number of successful extensions: 19198
Number of sequences better than 10.0: 89
Number of HSP's better than 10.0 without gapping: 18806
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 19168
length of database: 575,637,011
effective HSP length: 95
effective length of database: 418,195,031
effective search space used: 31364627325
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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