Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0006_M19
(513 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
L07033-1|AAA92733.1| 325|Homo sapiens hydroxymethylglutaryl-CoA... 152 8e-37
CR456884-1|CAG33165.1| 325|Homo sapiens HMGCL protein. 152 8e-37
BT009792-1|AAP88794.1| 325|Homo sapiens 3-hydroxymethyl-3-methy... 152 8e-37
BC010570-1|AAH10570.1| 325|Homo sapiens 3-hydroxymethyl-3-methy... 152 8e-37
AL031295-19|CAI23161.1| 300|Homo sapiens 3-hydroxymethyl-3-meth... 145 9e-35
U49719-1|AAB19099.1| 305|Homo sapiens hydroxymethylglutaryl-CoA... 143 3e-34
BC024194-1|AAH24194.2| 340|Homo sapiens 3-hydroxymethyl-3-methy... 143 3e-34
AK127587-1|BAC87045.1| 297|Homo sapiens protein ( Homo sapiens ... 143 3e-34
AL590406-1|CAI40661.1| 157|Homo sapiens protein ( Human DNA seq... 76 8e-21
AL590290-1|CAI39775.1| 157|Homo sapiens protein ( Human DNA seq... 76 8e-21
AL137605-1|CAB70838.1| 157|Homo sapiens hypothetical protein pr... 76 8e-21
AL590406-2|CAI40662.1| 241|Homo sapiens protein ( Human DNA seq... 74 3e-13
Z98742-4|CAI95645.1| 481|Homo sapiens lactation elevated 1 prot... 29 7.2
Z98742-3|CAO03483.1| 348|Homo sapiens lactation elevated 1 prot... 29 7.2
BC018445-1|AAH18445.2| 481|Homo sapiens lactation elevated 1 pr... 29 7.2
AL356121-3|CAI95324.1| 481|Homo sapiens lactation elevated 1 pr... 29 7.2
AL356121-2|CAO03617.1| 348|Homo sapiens lactation elevated 1 pr... 29 7.2
AL353706-3|CAI95698.1| 481|Homo sapiens lactation elevated 1 pr... 29 7.2
AL353706-2|CAO03571.1| 348|Homo sapiens lactation elevated 1 pr... 29 7.2
AL139106-2|CAI95701.1| 481|Homo sapiens lactation elevated 1 pr... 29 7.2
AL139106-1|CAO03511.1| 348|Homo sapiens lactation elevated 1 pr... 29 7.2
AF520418-1|AAM74228.1| 481|Homo sapiens lactation elevated 1 pr... 29 7.2
>L07033-1|AAA92733.1| 325|Homo sapiens hydroxymethylglutaryl-CoA
lyase protein.
Length = 325
Score = 152 bits (368), Expect = 8e-37
Identities = 72/141 (51%), Positives = 96/141 (68%)
Frame = +3
Query: 78 RIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLK 257
R++ L ++R++S M T ++I EVGPRDGLQNE V T +KI+LI+ L +AGL
Sbjct: 11 RLVGLASLRAVST-SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLS 69
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPA 437
IE+ SFVSPKW+ QM D EV+K + K +NYPVL PNLKG+ A +EV IF A
Sbjct: 70 VIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGA 129
Query: 438 GSEGFSQKNLNCSVEEGLRRF 500
SE F++KN+NCS+EE +RF
Sbjct: 130 ASELFTKKNINCSIEESFQRF 150
>CR456884-1|CAG33165.1| 325|Homo sapiens HMGCL protein.
Length = 325
Score = 152 bits (368), Expect = 8e-37
Identities = 72/141 (51%), Positives = 96/141 (68%)
Frame = +3
Query: 78 RIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLK 257
R++ L ++R++S M T ++I EVGPRDGLQNE V T +KI+LI+ L +AGL
Sbjct: 11 RLVGLASLRAVST-SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLS 69
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPA 437
IE+ SFVSPKW+ QM D EV+K + K +NYPVL PNLKG+ A +EV IF A
Sbjct: 70 VIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGA 129
Query: 438 GSEGFSQKNLNCSVEEGLRRF 500
SE F++KN+NCS+EE +RF
Sbjct: 130 ASELFTKKNINCSIEESFQRF 150
>BT009792-1|AAP88794.1| 325|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduri protein.
Length = 325
Score = 152 bits (368), Expect = 8e-37
Identities = 72/141 (51%), Positives = 96/141 (68%)
Frame = +3
Query: 78 RIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLK 257
R++ L ++R++S M T ++I EVGPRDGLQNE V T +KI+LI+ L +AGL
Sbjct: 11 RLVGLASLRAVST-SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLS 69
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPA 437
IE+ SFVSPKW+ QM D EV+K + K +NYPVL PNLKG+ A +EV IF A
Sbjct: 70 VIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGA 129
Query: 438 GSEGFSQKNLNCSVEEGLRRF 500
SE F++KN+NCS+EE +RF
Sbjct: 130 ASELFTKKNINCSIEESFQRF 150
>BC010570-1|AAH10570.1| 325|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
(hydroxymethylglutaricaciduri protein.
Length = 325
Score = 152 bits (368), Expect = 8e-37
Identities = 72/141 (51%), Positives = 96/141 (68%)
Frame = +3
Query: 78 RIISLKAIRSISNLKHMSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLK 257
R++ L ++R++S M T ++I EVGPRDGLQNE V T +KI+LI+ L +AGL
Sbjct: 11 RLVGLASLRAVST-SSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLS 69
Query: 258 NIESASFVSPKWMKQMSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPA 437
IE+ SFVSPKW+ QM D EV+K + K +NYPVL PNLKG+ A +EV IF A
Sbjct: 70 VIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGA 129
Query: 438 GSEGFSQKNLNCSVEEGLRRF 500
SE F++KN+NCS+EE +RF
Sbjct: 130 ASELFTKKNINCSIEESFQRF 150
>AL031295-19|CAI23161.1| 300|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyaseclass T
protein.
Length = 300
Score = 145 bits (351), Expect = 9e-35
Identities = 68/125 (54%), Positives = 86/125 (68%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
M T ++I EVGPRDGLQNE V T +KI+LI+ L +AGL IE+ SFVSPKW+ QM
Sbjct: 1 MGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 60
Query: 306 SDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
D EV+K + K +NYPVL PNLKG+ A +EV IF A SE F++KN+NCS+EE
Sbjct: 61 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 120
Query: 486 GLRRF 500
+RF
Sbjct: 121 SFQRF 125
>U49719-1|AAB19099.1| 305|Homo sapiens hydroxymethylglutaryl-CoA
lyase protein.
Length = 305
Score = 143 bits (347), Expect = 3e-34
Identities = 67/125 (53%), Positives = 86/125 (68%)
Frame = +3
Query: 126 MSTSVPDIRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQM 305
M T ++I EVGP+DGLQNE V T +KI+LI+ L +AGL IE+ SFVSPKW+ QM
Sbjct: 6 MGTLPKRVKIVEVGPQDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQM 65
Query: 306 SDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEE 485
D EV+K + K +NYPVL PNLKG+ A +EV IF A SE F++KN+NCS+EE
Sbjct: 66 GDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEE 125
Query: 486 GLRRF 500
+RF
Sbjct: 126 SFQRF 130
>BC024194-1|AAH24194.2| 340|Homo sapiens
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
protein.
Length = 340
Score = 143 bits (347), Expect = 3e-34
Identities = 66/121 (54%), Positives = 85/121 (70%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ QM+D EVM
Sbjct: 48 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVM 107
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
K + + V YPVL PNL+G+ A E+++F A SE FS+KN+NCS+EE + +F +
Sbjct: 108 KGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEE 167
Query: 507 V 509
V
Sbjct: 168 V 168
>AK127587-1|BAC87045.1| 297|Homo sapiens protein ( Homo sapiens
cDNA FLJ45682 fis, clone FCBBF3001018, moderately
similar to Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4).
).
Length = 297
Score = 143 bits (347), Expect = 3e-34
Identities = 66/121 (54%), Positives = 85/121 (70%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDGVEVM 326
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ QM+D EVM
Sbjct: 78 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVM 137
Query: 327 KNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVEEGLRRFTD 506
K + + V YPVL PNL+G+ A E+++F A SE FS+KN+NCS+EE + +F +
Sbjct: 138 KGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEE 197
Query: 507 V 509
V
Sbjct: 198 V 198
>AL590406-1|CAI40661.1| 157|Homo sapiens protein ( Human DNA
sequence from clone RP11-418P12 on chromosome 6. ).
Length = 157
Score = 76.2 bits (179), Expect(2) = 8e-21
Identities = 35/56 (62%), Positives = 42/56 (75%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDG 314
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ Q++ G
Sbjct: 54 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQVAAG 109
Score = 43.6 bits (98), Expect(2) = 8e-21
Identities = 16/31 (51%), Positives = 25/31 (80%)
Frame = +3
Query: 417 EVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
E+++F A SE FS+KN+NCS+EE + +F +V
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEV 142
>AL590290-1|CAI39775.1| 157|Homo sapiens protein ( Human DNA
sequence from clone RP11-228O6 on chromosome 6. ).
Length = 157
Score = 76.2 bits (179), Expect(2) = 8e-21
Identities = 35/56 (62%), Positives = 42/56 (75%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDG 314
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ Q++ G
Sbjct: 54 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQVAAG 109
Score = 43.6 bits (98), Expect(2) = 8e-21
Identities = 16/31 (51%), Positives = 25/31 (80%)
Frame = +3
Query: 417 EVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
E+++F A SE FS+KN+NCS+EE + +F +V
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEV 142
>AL137605-1|CAB70838.1| 157|Homo sapiens hypothetical protein
protein.
Length = 157
Score = 76.2 bits (179), Expect(2) = 8e-21
Identities = 35/56 (62%), Positives = 42/56 (75%)
Frame = +3
Query: 147 IRIYEVGPRDGLQNESKFVPTDIKIELINKLVQAGLKNIESASFVSPKWMKQMSDG 314
++I EVGPRDGLQNE VPTDIKIE IN+L Q GL IE SFVS +W+ Q++ G
Sbjct: 54 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQVAAG 109
Score = 43.6 bits (98), Expect(2) = 8e-21
Identities = 16/31 (51%), Positives = 25/31 (80%)
Frame = +3
Query: 417 EVAIFPAGSEGFSQKNLNCSVEEGLRRFTDV 509
E+++F A SE FS+KN+NCS+EE + +F +V
Sbjct: 112 EISVFGAASESFSKKNINCSIEESMGKFEEV 142
>AL590406-2|CAI40662.1| 241|Homo sapiens protein ( Human DNA
sequence from clone RP11-418P12 on chromosome 6. ).
Length = 241
Score = 74.1 bits (174), Expect = 3e-13
Identities = 32/69 (46%), Positives = 46/69 (66%)
Frame = +3
Query: 303 MSDGVEVMKNLPKVHNVNYPVLVPNLKGYSIAKQCNVEEVAIFPAGSEGFSQKNLNCSVE 482
M+D EVMK + + V YPVL PNL+G+ A E+++F A SE FS+KN+NCS+E
Sbjct: 1 MADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIE 60
Query: 483 EGLRRFTDV 509
E + +F +V
Sbjct: 61 ESMGKFEEV 69
>Z98742-4|CAI95645.1| 481|Homo sapiens lactation elevated 1
protein.
Length = 481
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 209 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 245
>Z98742-3|CAO03483.1| 348|Homo sapiens lactation elevated 1
protein.
Length = 348
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 76 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 112
>BC018445-1|AAH18445.2| 481|Homo sapiens lactation elevated 1
protein.
Length = 481
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 209 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 245
>AL356121-3|CAI95324.1| 481|Homo sapiens lactation elevated 1
protein.
Length = 481
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 209 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 245
>AL356121-2|CAO03617.1| 348|Homo sapiens lactation elevated 1
protein.
Length = 348
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 76 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 112
>AL353706-3|CAI95698.1| 481|Homo sapiens lactation elevated 1
protein.
Length = 481
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 209 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 245
>AL353706-2|CAO03571.1| 348|Homo sapiens lactation elevated 1
protein.
Length = 348
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 76 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 112
>AL139106-2|CAI95701.1| 481|Homo sapiens lactation elevated 1
protein.
Length = 481
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 209 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 245
>AL139106-1|CAO03511.1| 348|Homo sapiens lactation elevated 1
protein.
Length = 348
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 76 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 112
>AF520418-1|AAM74228.1| 481|Homo sapiens lactation elevated 1
protein.
Length = 481
Score = 29.5 bits (63), Expect = 7.2
Identities = 11/37 (29%), Positives = 22/37 (59%)
Frame = -3
Query: 307 LICFIHFGLTKLADSIFFNPAWTNLFISSILISVGTN 197
L+CF F +T +AD++ + NLF + +++ +N
Sbjct: 209 LLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSN 245
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 63,118,949
Number of Sequences: 237096
Number of extensions: 1185293
Number of successful extensions: 1714
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 1674
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1714
length of database: 76,859,062
effective HSP length: 85
effective length of database: 56,705,902
effective search space used: 4820001670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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