Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0006_M16
(378 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Y14487-1|CAB54840.1| 347|Homo sapiens cytosolic serine hydroxym... 129 3e-30
Y14485-1|CAB54838.1| 483|Homo sapiens cytosolic serine hydroxym... 129 3e-30
L23928-3|AAA36019.1| 403|Homo sapiens serine hydroxymethyltrans... 129 3e-30
L23928-2|AAA36018.1| 444|Homo sapiens serine hydroxymethyltrans... 129 3e-30
L23928-1|AAA36020.1| 483|Homo sapiens serine hydroxymethyltrans... 129 3e-30
L11931-1|AAA63257.1| 483|Homo sapiens serine hydroxymethyltrans... 129 3e-30
BC038598-1|AAH38598.1| 483|Homo sapiens serine hydroxymethyltra... 129 3e-30
BC022874-1|AAH22874.1| 444|Homo sapiens serine hydroxymethyltra... 129 3e-30
BC007979-1|AAH07979.1| 483|Homo sapiens serine hydroxymethyltra... 129 3e-30
AK223552-1|BAD97272.1| 483|Homo sapiens serine hydroxymethyltra... 129 3e-30
U23143-1|AAA64572.1| 483|Homo sapiens mitochondrial serine hydr... 119 4e-27
L11932-1|AAA63258.1| 474|Homo sapiens serine hydroxymethyltrans... 119 4e-27
BT006866-1|AAP35512.1| 504|Homo sapiens serine hydroxymethyltra... 119 4e-27
BC044211-1|AAH44211.1| 504|Homo sapiens serine hydroxymethyltra... 119 4e-27
BC032584-1|AAH32584.1| 494|Homo sapiens SHMT2 protein protein. 119 4e-27
BC013677-1|AAH13677.1| 504|Homo sapiens serine hydroxymethyltra... 119 4e-27
BC011911-1|AAH11911.1| 504|Homo sapiens serine hydroxymethyltra... 119 4e-27
AK223555-1|BAD97275.1| 504|Homo sapiens serine hydroxymethyltra... 119 4e-27
BC091501-1|AAH91501.1| 480|Homo sapiens SHMT2 protein protein. 60 3e-09
Y14488-1|CAB54841.1| 129|Homo sapiens 14 kDa protein protein. 57 2e-08
AK055053-1|BAB70847.1| 135|Homo sapiens protein. 37 0.019
Y14490-1|CAB54843.1| 20|Homo sapiens cytosolic serine hydroxym... 29 6.6
>Y14487-1|CAB54840.1| 347|Homo sapiens cytosolic serine
hydroxymethyltransferase protein.
Length = 347
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>Y14485-1|CAB54838.1| 483|Homo sapiens cytosolic serine
hydroxymethyltransferase protein.
Length = 483
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>L23928-3|AAA36019.1| 403|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 403
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>L23928-2|AAA36018.1| 444|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 444
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>L23928-1|AAA36020.1| 483|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 483
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>L11931-1|AAA63257.1| 483|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 483
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>BC038598-1|AAH38598.1| 483|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) protein.
Length = 483
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>BC022874-1|AAH22874.1| 444|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) protein.
Length = 444
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>BC007979-1|AAH07979.1| 483|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) protein.
Length = 483
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>AK223552-1|BAD97272.1| 483|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) isoform 1 variant
protein.
Length = 483
Score = 129 bits (312), Expect = 3e-30
Identities = 59/98 (60%), Positives = 76/98 (77%)
Frame = +1
Query: 85 NNKLLNGNLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGM 264
++K+L L ++D E++N+I KE RQ+ GLE+IASENF S VL+ L SCL+NKYSEG
Sbjct: 18 HDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGY 77
Query: 265 PYQRYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
P QRYYGG EFIDE+E L Q R+L+ YKL+P+ WGVNV
Sbjct: 78 PGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNV 115
>U23143-1|AAA64572.1| 483|Homo sapiens mitochondrial serine
hydroxymethyltransferase protein.
Length = 483
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 27 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 86
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 87 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 117
>L11932-1|AAA63258.1| 474|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 474
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 18 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 77
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 78 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 108
>BT006866-1|AAP35512.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 108 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 138
>BC044211-1|AAH44211.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 108 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 138
>BC032584-1|AAH32584.1| 494|Homo sapiens SHMT2 protein protein.
Length = 494
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 108 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 138
>BC013677-1|AAH13677.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 108 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 138
>BC011911-1|AAH11911.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 108 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 138
>AK223555-1|BAD97275.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) variant
protein.
Length = 504
Score = 119 bits (286), Expect = 4e-27
Identities = 53/91 (58%), Positives = 70/91 (76%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPYQRYYG 285
+L ++DPE++ L+ +EK RQ GLE+IASENF S L+ L SCL+NKYSEG P +RYYG
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 286 GNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
G E +DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 108 GAEVVDEIELLCQRRALEAFDLDPAQWGVNV 138
>BC091501-1|AAH91501.1| 480|Homo sapiens SHMT2 protein protein.
Length = 480
Score = 59.7 bits (138), Expect = 3e-09
Identities = 33/88 (37%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Frame = +1
Query: 133 FNLITKEKKRQQAGLEMIASE--NFTSVPVLQCLSSCLHNKYSEGMPY----QRYYGGNE 294
F L T + R + G + A + +L+C S C + + + QRYYGG E
Sbjct: 27 FGLSTATQPRLRLGKQTGAGQARRACRTVILRCGSCCRGRRTGSVVAWSSLPQRYYGGAE 86
Query: 295 FIDEIEILAQNRSLETYKLNPEEWGVNV 378
+DEIE+L Q R+LE + L+P +WGVNV
Sbjct: 87 VVDEIELLCQRRALEAFDLDPAQWGVNV 114
>Y14488-1|CAB54841.1| 129|Homo sapiens 14 kDa protein protein.
Length = 129
Score = 57.2 bits (132), Expect = 2e-08
Identities = 23/35 (65%), Positives = 29/35 (82%)
Frame = +1
Query: 274 RYYGGNEFIDEIEILAQNRSLETYKLNPEEWGVNV 378
RYYGG EFIDE+E L Q R+L+ YKL+P+ WGV+V
Sbjct: 65 RYYGGTEFIDELETLCQKRALQAYKLDPQCWGVDV 99
>AK055053-1|BAB70847.1| 135|Homo sapiens protein.
Length = 135
Score = 37.1 bits (82), Expect = 0.019
Identities = 16/30 (53%), Positives = 24/30 (80%)
Frame = +1
Query: 106 NLWETDPELFNLITKEKKRQQAGLEMIASE 195
+L ++DPE++ L+ +EK RQ GLE+IASE
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASE 77
>Y14490-1|CAB54843.1| 20|Homo sapiens cytosolic serine
hydroxymethyltransferase protein.
Length = 20
Score = 28.7 bits (61), Expect = 6.6
Identities = 11/20 (55%), Positives = 16/20 (80%)
Frame = +1
Query: 130 LFNLITKEKKRQQAGLEMIA 189
++N+I KE RQ+ GLE+IA
Sbjct: 1 VYNIIKKESNRQRVGLELIA 20
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 53,863,013
Number of Sequences: 237096
Number of extensions: 1021365
Number of successful extensions: 2602
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 2584
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2602
length of database: 76,859,062
effective HSP length: 81
effective length of database: 57,654,286
effective search space used: 2536788584
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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