Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0006_F08
(660 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 140 4e-32
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 130 2e-29
UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2; ... 112 8e-24
UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:... 85 1e-15
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 42 0.010
UniRef50_Q9HS43 Cluster: Phosphoribosylaminoimidazole-succinocar... 40 0.070
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 39 0.093
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 37 0.37
UniRef50_A0PKS3 Cluster: Conserved hypothetical transmembrane pr... 36 0.86
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 36 0.86
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 36 1.1
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 36 1.1
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 35 1.5
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 35 2.0
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 35 2.0
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 34 2.6
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 34 2.6
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 34 2.6
UniRef50_Q192V6 Cluster: Putative uncharacterized protein; n=2; ... 34 3.5
UniRef50_A0B9A9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 34 3.5
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 34 3.5
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 34 3.5
UniRef50_A2RRV1 Cluster: Zgc:158218 protein; n=3; Danio rerio|Re... 33 4.6
UniRef50_Q4QED5 Cluster: Putative uncharacterized protein; n=3; ... 33 4.6
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 33 4.6
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 33 4.6
UniRef50_Q4RWM8 Cluster: Chromosome 3 SCAF14987, whole genome sh... 33 6.1
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 33 8.0
UniRef50_A0WCV8 Cluster: Chromosome segregation protein SMC; n=2... 33 8.0
UniRef50_Q7XUI8 Cluster: OSJNBb0103I08.17 protein; n=3; Oryza sa... 33 8.0
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 33 8.0
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 140 bits (338), Expect = 4e-32
Identities = 63/79 (79%), Positives = 73/79 (92%)
Frame = +3
Query: 174 LNGSPGYINLCDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVGLPLTKENASVCMVS 353
LNG+PG+INLCDALNAWQLVKELKEALG+PAAASFKHVSPAGAAVG+PL+++ A VCMV
Sbjct: 231 LNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVY 290
Query: 354 DLLEALTPLACAYARARGA 410
DL + LTP++ AYARARGA
Sbjct: 291 DLYKTLTPISAAYARARGA 309
Score = 123 bits (296), Expect = 4e-27
Identities = 61/107 (57%), Positives = 73/107 (68%)
Frame = +1
Query: 340 CVWYRIYWKXXXXXXXXXXXLAGPNALTSSGDFVALSDACDEATARIISREVFDGIVAPG 519
C+ Y +Y K G + ++S GDFVALSD CD TA+IISREV DGI+APG
Sbjct: 287 CMVYDLY-KTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPG 345
Query: 520 YTPEALNILRKKKGGNYCVLQMDPSYEPDLTERKTLYGLSLEQRRND 660
Y EAL IL KKK GNYCVLQMD SY+PD E +TL+GL L Q+RN+
Sbjct: 346 YEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNN 392
Score = 85.0 bits (201), Expect = 1e-15
Identities = 35/53 (66%), Positives = 45/53 (84%)
Frame = +2
Query: 11 QGFTHTSEYDLAISDYFRRQYSAGQSQLTLRYGMNPHQKPAQVFTTRDRLPLT 169
+ FTHT++YD AISDYFR+QYS G SQ+ LRYGMNPHQ PAQ++T + +LP+T
Sbjct: 177 KAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPIT 229
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 130 bits (315), Expect = 2e-29
Identities = 59/79 (74%), Positives = 71/79 (89%)
Frame = +3
Query: 174 LNGSPGYINLCDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVGLPLTKENASVCMVS 353
+NGSPG+INLCDALNAWQLV+EL +ALG+ AA SFKHVSPAGAAVG+PL++E A VCMV
Sbjct: 214 VNGSPGFINLCDALNAWQLVRELSKALGVAAATSFKHVSPAGAAVGVPLSEEEARVCMVH 273
Query: 354 DLLEALTPLACAYARARGA 410
D+++ LTPLA AYARARG+
Sbjct: 274 DMMKDLTPLATAYARARGS 292
Score = 103 bits (247), Expect = 4e-21
Identities = 57/106 (53%), Positives = 67/106 (63%), Gaps = 22/106 (20%)
Frame = +1
Query: 406 GPNALTSSGDFVALSDACDEATARIISREV----------------------FDGIVAPG 519
G + ++S GDF+ALSD CD TA+IISREV DGI+APG
Sbjct: 291 GSDRMSSFGDFIALSDVCDVPTAKIISREVNRGASGVSSPASCGNNRIFSQVSDGIIAPG 350
Query: 520 YTPEALNILRKKKGGNYCVLQMDPSYEPDLTERKTLYGLSLEQRRN 657
Y EAL IL KKK GNYCVLQMDP YEPD TE + L+GL L+Q+RN
Sbjct: 351 YDEEALKILSKKKNGNYCVLQMDPEYEPDETEVRVLFGLYLKQKRN 396
Score = 38.3 bits (85), Expect = 0.16
Identities = 15/21 (71%), Positives = 17/21 (80%)
Frame = +2
Query: 104 YGMNPHQKPAQVFTTRDRLPL 166
YGMNPHQ PAQ++T R LPL
Sbjct: 191 YGMNPHQAPAQLYTLRPALPL 211
>UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 420
Score = 112 bits (269), Expect = 8e-24
Identities = 56/79 (70%), Positives = 63/79 (79%), Gaps = 2/79 (2%)
Frame = +3
Query: 174 LNGSPGYINLCDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVGLPLTKENASVCMVS 353
LNGSPGYIN+ D LN WQLVKEL +A +PAAASFKHVSPAGAAVGLPL + A+ CMVS
Sbjct: 6 LNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAACCMVS 65
Query: 354 DL-LEALTP-LACAYARAR 404
DL ++ P LA AYARAR
Sbjct: 66 DLPIDTKKPSLAAAYARAR 84
Score = 112 bits (269), Expect = 8e-24
Identities = 48/85 (56%), Positives = 68/85 (80%)
Frame = +1
Query: 406 GPNALTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQM 585
G + ++S GDF+ALS+ CDE TA+II+REV DG+VAP + P AL++L KKK GNYCVL++
Sbjct: 102 GADRMSSFGDFIALSEKCDELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKI 161
Query: 586 DPSYEPDLTERKTLYGLSLEQRRND 660
+P+Y P TE +T++GL L Q+RN+
Sbjct: 162 NPNYLPSETEERTVFGLRLRQKRNN 186
>UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:
IMP cyclohydrolase - Geobacter sp. FRC-32
Length = 388
Score = 85.0 bits (201), Expect = 1e-15
Identities = 38/84 (45%), Positives = 55/84 (65%)
Frame = +1
Query: 406 GPNALTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQM 585
G + + S GD A+SD D + A ++ EV D I+APG+ P AL IL+ KK G Y +LQ+
Sbjct: 104 GGDRMCSFGDVAAVSDIVDVSLANVLKSEVSDLIIAPGFEPAALEILKAKKQGTYLILQI 163
Query: 586 DPSYEPDLTERKTLYGLSLEQRRN 657
DP YEP E++ ++G L+Q+RN
Sbjct: 164 DPDYEPAEIEQREVFGFGLQQKRN 187
Score = 82.2 bits (194), Expect = 1e-14
Identities = 45/79 (56%), Positives = 52/79 (65%), Gaps = 1/79 (1%)
Frame = +3
Query: 174 LNGSPGYINLCDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVGLPLTKENASVCMVS 353
LNG+P YIN+ DAL AWQL +ELK A P AASFKH SPAGAAV L S C
Sbjct: 29 LNGTPSYINILDALGAWQLARELKIATSKPGAASFKHTSPAGAAVAGALPD---SYCASQ 85
Query: 354 DLLEA-LTPLACAYARARG 407
L ++ L+P+A AY RARG
Sbjct: 86 FLSQSDLSPVATAYVRARG 104
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 42.3 bits (95), Expect = 0.010
Identities = 22/49 (44%), Positives = 30/49 (61%)
Frame = +1
Query: 412 NALTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
+A ++ G V++++ D A A I + IVAPGYTPEA IL KKK
Sbjct: 327 DAESAFGGIVSVTEFVDAAMAARIKETFLEVIVAPGYTPEAREILAKKK 375
Score = 41.1 bits (92), Expect = 0.023
Identities = 23/42 (54%), Positives = 28/42 (66%), Gaps = 2/42 (4%)
Frame = +3
Query: 192 YINLCDALNAWQLVKELKEAL--GLPAAASFKHVSPAGAAVG 311
Y NL DA A L+++LK L G AAA FKH+SP GAA+G
Sbjct: 269 YNNLLDADAALGLIRDLKAGLPEGGKAAAVFKHLSPCGAAIG 310
Score = 33.1 bits (72), Expect = 6.1
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 16/62 (25%)
Frame = +2
Query: 11 QGFTHTSEYDLAISDYFRRQ----------------YSAGQSQLTLRYGMNPHQKPAQVF 142
+ F HT+ YD AI+ Y R + +G+S LRYG NPHQ+ A+ F
Sbjct: 186 KAFAHTAAYDAAIASYLARHDDAGEALDAGTIPEGLFVSGESVAELRYGENPHQQ-ARFF 244
Query: 143 TT 148
T
Sbjct: 245 AT 246
>UniRef50_Q9HS43 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
formyltransferase; n=5; Halobacteriaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide
formyltransferase - Halobacterium salinarium
(Halobacterium halobium)
Length = 595
Score = 39.5 bits (88), Expect = 0.070
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Frame = +1
Query: 412 NALTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDP 591
+A ++ G VAL+ CD TA ++ + +VAPGYT +A+++L K N VL +
Sbjct: 375 DAKSAFGGIVALNRECDAETATRVADSFKEVVVAPGYTDDAVDVLTAK--SNLRVLDVGT 432
Query: 592 -SYEPDLTERKTLYGLSLEQRRN 657
P L G L Q RN
Sbjct: 433 LDGTPAPVTETPLVGGRLVQERN 455
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 39.1 bits (87), Expect = 0.093
Identities = 19/43 (44%), Positives = 27/43 (62%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
G +AL+ DE TA +S+ + ++AP Y ALNIL+KKK
Sbjct: 291 GFVLALNRKVDEETAMELSKHYIEVLIAPDYDEPALNILKKKK 333
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 37.1 bits (82), Expect = 0.37
Identities = 15/43 (34%), Positives = 25/43 (58%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
G +A + D A A +S + + ++AP YT +AL +LR K+
Sbjct: 317 GGIIAFNGEVDRAAAEAVSAQFLEVLIAPSYTADALELLRAKQ 359
>UniRef50_A0PKS3 Cluster: Conserved hypothetical transmembrane
protein; n=3; Mycobacterium|Rep: Conserved hypothetical
transmembrane protein - Mycobacterium ulcerans (strain
Agy99)
Length = 172
Score = 35.9 bits (79), Expect = 0.86
Identities = 26/69 (37%), Positives = 33/69 (47%)
Frame = -3
Query: 418 TRWAPRARAYAHASGVSASSKSDTIHTDAFSLVKGSPTAAPAGDTCLKLAAAGRPSASFN 239
+R APR+ A SG + S SD+ TDA A G L LAAA P +S
Sbjct: 27 SRTAPRSNAMTAISGPTTRSLSDS--TDALLRFAMRADATLTGLMGLALAAAADPISSLT 84
Query: 238 SLTSCQAFN 212
LTS Q ++
Sbjct: 85 GLTSAQEYS 93
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 35.9 bits (79), Expect = 0.86
Identities = 22/65 (33%), Positives = 36/65 (55%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDPSYEPDL 609
G VA + D ATA +S+ + +VAP + +AL IL +KK N +L++D + +
Sbjct: 302 GGIVACNRPVDAATAEQLSQIFLEIVVAPSFESQALEILTQKK--NIRLLELDVTSDNKQ 359
Query: 610 TERKT 624
+ R T
Sbjct: 360 SNRLT 364
Score = 32.7 bits (71), Expect = 8.0
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 9/48 (18%)
Frame = +2
Query: 17 FTHTSEYDLAISDYFRRQ--------YSAGQSQL-TLRYGMNPHQKPA 133
F HT+ YD I++YF Q Y+ ++ LRYG NPHQ+ A
Sbjct: 175 FRHTASYDAMIANYFLSQTEEQYPESYTVTYEKVQDLRYGENPHQQAA 222
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 35.5 bits (78), Expect = 1.1
Identities = 19/54 (35%), Positives = 28/54 (51%)
Frame = +1
Query: 418 LTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVL 579
+++ G VAL+ D TAR + + +VAP TPEA +L KK +L
Sbjct: 353 VSAFGGIVALNQPLDAETARRLVEPFLECVVAPDCTPEAAELLSVKKNLRVLIL 406
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 35.5 bits (78), Expect = 1.1
Identities = 17/59 (28%), Positives = 31/59 (52%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDPSYEPD 606
G +AL+ D+ATA + + I+AP ++ EAL++L KK L + + + +
Sbjct: 304 GGIIALNREVDKATAEALHNIFLEIIIAPSFSQEALDVLTAKKNLRLVTLDVSAAVQKE 362
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 35.1 bits (77), Expect = 1.5
Identities = 24/77 (31%), Positives = 43/77 (55%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDPSYEPDL 609
G VAL+ A A + + I+AP +T EAL+IL++KK N +L++D + + +
Sbjct: 285 GGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKK--NVRLLEIDMTIDSNE 342
Query: 610 TERKTLYGLSLEQRRND 660
E ++ G L Q +++
Sbjct: 343 EEFVSVSGGYLVQDKDN 359
Score = 32.7 bits (71), Expect = 8.0
Identities = 20/44 (45%), Positives = 25/44 (56%)
Frame = +2
Query: 17 FTHTSEYDLAISDYFRRQYSAGQSQLTLRYGMNPHQKPAQVFTT 148
F HT+EYD AI +F+ G + TLRYG NP Q V T+
Sbjct: 174 FEHTAEYDEAIVRFFK-----GDKE-TLRYGENPQQSAYFVRTS 211
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 34.7 bits (76), Expect = 2.0
Identities = 21/40 (52%), Positives = 22/40 (55%)
Frame = +3
Query: 192 YINLCDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVG 311
Y N DA NA Q VKEL A PA A KH +P G A G
Sbjct: 246 YNNYVDADNALQTVKELGNAS--PAVAIVKHNNPCGLATG 283
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 34.7 bits (76), Expect = 2.0
Identities = 19/43 (44%), Positives = 24/43 (55%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
G V L+ D ATA + + I+APGY+ EAL IL KK
Sbjct: 304 GGIVVLNREVDAATAEKMHPIFLEIIIAPGYSAEALAILTNKK 346
Score = 32.7 bits (71), Expect = 8.0
Identities = 14/34 (41%), Positives = 21/34 (61%), Gaps = 1/34 (2%)
Frame = +2
Query: 17 FTHTSEYDLAISDYFRRQYSAGQ-SQLTLRYGMN 115
F HT+ YD I+DYF +Q + +LT+ Y +N
Sbjct: 176 FRHTAAYDALIADYFTKQVGEDKPEKLTITYDLN 209
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 34.3 bits (75), Expect = 2.6
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Frame = +1
Query: 412 NALTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDP 591
++ ++ G +A++ D ATAR I+ + I+AP T EA+ ++ +K + P
Sbjct: 305 DSTSAFGGIIAMNRKLDAATARAITGIFTEVIIAPDATEEAIAVIAARKTLRLLLAGALP 364
Query: 592 S-YEPDLTERKTLYGLSLEQRRN 657
E LT + GL ++ R N
Sbjct: 365 DPREAGLTAKTVAGGLLVQSRDN 387
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 34.3 bits (75), Expect = 2.6
Identities = 28/83 (33%), Positives = 39/83 (46%)
Frame = +1
Query: 412 NALTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDP 591
+A ++ G VAL+ D TA + + + IVAPG EA IL KK +L D
Sbjct: 298 DATSAFGGIVALNQPLDGPTAAAMVKTFLECIVAPGCDAEAQEILAKKNNLRVLILP-DL 356
Query: 592 SYEPDLTERKTLYGLSLEQRRND 660
+ P T K + G L Q +D
Sbjct: 357 ATGPSQT-IKAIAGGFLVQSADD 378
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 34.3 bits (75), Expect = 2.6
Identities = 24/68 (35%), Positives = 33/68 (48%), Gaps = 12/68 (17%)
Frame = +2
Query: 11 QGFTHTSEYDLAISDYFRRQYS---------AGQSQLTLRYGMNPHQKPA---QVFTTRD 154
+ F+HT+ YD AIS +F +Q + + LRYG NPHQ + +FT D
Sbjct: 175 KAFSHTAMYDAAISSWFYKQSGEVFPDVLNLSFIKKQKLRYGENPHQAASFYEPLFTKSD 234
Query: 155 RLPLTNTE 178
PL E
Sbjct: 235 FSPLQGKE 242
>UniRef50_Q192V6 Cluster: Putative uncharacterized protein; n=2;
Desulfitobacterium hafniense|Rep: Putative
uncharacterized protein - Desulfitobacterium hafniense
(strain DCB-2)
Length = 398
Score = 33.9 bits (74), Expect = 3.5
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Frame = +3
Query: 156 VCH*PTLNGSPGYINLCDALNAWQ-LVKELKEALGLPAAASFKHVSPAGAAVGLPLTKEN 332
VC ++ GYI + + + ++ EL+E G+PAAA K SP G +G T E
Sbjct: 288 VCLKRVIHQPAGYIGMIGSRRRVKAMLAELQEE-GIPAAALEKLYSPIGLKIGAE-TPEE 345
Query: 333 ASVCMVSDLLE 365
+VC++ ++++
Sbjct: 346 IAVCILGEIIK 356
>UniRef50_A0B9A9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Methanosaeta thermophila PT|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Methanosaeta thermophila (strain DSM
6194 / PT) (Methanothrixthermophila (strain DSM 6194 /
PT))
Length = 451
Score = 33.9 bits (74), Expect = 3.5
Identities = 15/43 (34%), Positives = 23/43 (53%)
Frame = +1
Query: 430 GDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
G + + D ATA I + ++APGY P+AL +L + K
Sbjct: 237 GGVIGFNMKVDLATAEAIGDSFVEVLIAPGYEPDALELLTRNK 279
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 33.9 bits (74), Expect = 3.5
Identities = 17/46 (36%), Positives = 29/46 (63%)
Frame = +1
Query: 421 TSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
+S G +A++ DE A+ + ++ + IVAP +T EA+ +L KKK
Sbjct: 250 SSFGGILAVNFEMDEEVAKSL-KKYLEVIVAPSFTQEAIEVLSKKK 294
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 33.9 bits (74), Expect = 3.5
Identities = 16/47 (34%), Positives = 27/47 (57%)
Frame = +1
Query: 418 LTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKK 558
+++ G VA +D D TA+ ++ + ++AP Y EAL L +KK
Sbjct: 296 VSAFGGIVAFNDKVDGETAKELTSMFLEVVIAPDYDEEALRELSRKK 342
>UniRef50_A2RRV1 Cluster: Zgc:158218 protein; n=3; Danio rerio|Rep:
Zgc:158218 protein - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 169
Score = 33.5 bits (73), Expect = 4.6
Identities = 15/46 (32%), Positives = 27/46 (58%), Gaps = 1/46 (2%)
Frame = -2
Query: 236 LNELPSVQRVTQVNVPGRTVQCWS-MANGREL*TLGPVSDEDSYHI 102
LN + + V+ N+ GR QC+ + N R+L GP+ +E ++H+
Sbjct: 5 LNSISGGRSVSSANICGRHTQCFDRILNKRDLHLSGPLGEEKAHHL 50
>UniRef50_Q4QED5 Cluster: Putative uncharacterized protein; n=3;
Leishmania|Rep: Putative uncharacterized protein -
Leishmania major
Length = 1638
Score = 33.5 bits (73), Expect = 4.6
Identities = 23/56 (41%), Positives = 26/56 (46%), Gaps = 1/56 (1%)
Frame = -3
Query: 409 APRARAYAHASGVSASSKSDTIHTDAFSL-VKGSPTAAPAGDTCLKLAAAGRPSAS 245
AP ARA HA +ASS S F + V S T + G L A RPSAS
Sbjct: 1358 APSARADLHAGTAAASSTSVAAPASLFEIHVGASSTVSSRGPDSLFRRATARPSAS 1413
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 33.5 bits (73), Expect = 4.6
Identities = 23/78 (29%), Positives = 40/78 (51%)
Frame = +1
Query: 418 LTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDPSY 597
+++ G VA+S D A+ I + ++AP ++ EA +++KK+ +L P
Sbjct: 288 VSAYGSIVAMSTPVDTDIAKEICSTFVEVLIAPSFSDEAREMMKKKENMRLLIL---PPA 344
Query: 598 EPDLTERKTLYGLSLEQR 651
EP E +T+ G L QR
Sbjct: 345 EP-ADEIRTIDGGILVQR 361
Score = 33.1 bits (72), Expect = 6.1
Identities = 21/55 (38%), Positives = 28/55 (50%), Gaps = 11/55 (20%)
Frame = +2
Query: 2 IGPQGFTHTSEYDLAISDY-----------FRRQYSAGQSQLTLRYGMNPHQKPA 133
+ + FT T+ YD AIS+Y + Q+ G+ LRYG NPHQK A
Sbjct: 166 LATKAFTRTAAYDAAISNYLNGIDKEFPDVYTMQFGNGRK---LRYGENPHQKAA 217
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 33.5 bits (73), Expect = 4.6
Identities = 17/40 (42%), Positives = 22/40 (55%)
Frame = +3
Query: 192 YINLCDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVG 311
Y NL DA AW+ V++ + PA KH +P G AVG
Sbjct: 261 YNNLVDADAAWECVRQFEA----PACVIVKHANPCGVAVG 296
>UniRef50_Q4RWM8 Cluster: Chromosome 3 SCAF14987, whole genome shotgun
sequence; n=8; Euteleostomi|Rep: Chromosome 3 SCAF14987,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 2229
Score = 33.1 bits (72), Expect = 6.1
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 3/49 (6%)
Frame = -3
Query: 316 GSPTAAPAG---DTCLKLAAAGRPSASFNSLTSCQAFNASHKLMYPGEP 179
G P+AAPAG D AAA S + + + Q+ AS K+ Y GEP
Sbjct: 958 GGPSAAPAGGAADHAAAAAAAAAASYAHAAPHTAQSRTASRKVAYTGEP 1006
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 32.7 bits (71), Expect = 8.0
Identities = 27/77 (35%), Positives = 36/77 (46%)
Frame = +1
Query: 418 LTSSGDFVALSDACDEATARIISREVFDGIVAPGYTPEALNILRKKKGGNYCVLQMDPSY 597
+++ G VAL+ D AR ++ + +V P TPEA L KK VL D +
Sbjct: 324 VSAFGGIVALNQTLDGEAARRLAEPFLECVVVPDCTPEAAEQLAAKKNLRLLVLP-DFAV 382
Query: 598 EPDLTERKTLYGLSLEQ 648
P T R TL G L Q
Sbjct: 383 GPAQTVR-TLAGGFLVQ 398
>UniRef50_A0WCV8 Cluster: Chromosome segregation protein SMC; n=2;
Desulfuromonadales|Rep: Chromosome segregation protein
SMC - Geobacter lovleyi SZ
Length = 1177
Score = 32.7 bits (71), Expect = 8.0
Identities = 17/46 (36%), Positives = 26/46 (56%)
Frame = +2
Query: 29 SEYDLAISDYFRRQYSAGQSQLTLRYGMNPHQKPAQVFTTRDRLPL 166
SE +L S + RQ+SAG++QLT G P + +++ D L L
Sbjct: 559 SEQELISSIQYLRQHSAGRAQLTFPAGNTPPRTTSEIIGAPDLLSL 604
>UniRef50_Q7XUI8 Cluster: OSJNBb0103I08.17 protein; n=3; Oryza
sativa|Rep: OSJNBb0103I08.17 protein - Oryza sativa
subsp. japonica (Rice)
Length = 458
Score = 32.7 bits (71), Expect = 8.0
Identities = 23/66 (34%), Positives = 35/66 (53%)
Frame = -3
Query: 406 PRARAYAHASGVSASSKSDTIHTDAFSLVKGSPTAAPAGDTCLKLAAAGRPSASFNSLTS 227
P A A A + S + + TDA S V P AAP+ TC A+ RPSAS +++++
Sbjct: 17 PEVAAPAPAPAPPSPSAAAAVSTDACSNVS-VPAAAPS--TCTSSWASTRPSASSSAVST 73
Query: 226 CQAFNA 209
+ + A
Sbjct: 74 PEPYEA 79
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 32.7 bits (71), Expect = 8.0
Identities = 16/50 (32%), Positives = 25/50 (50%), Gaps = 9/50 (18%)
Frame = +2
Query: 11 QGFTHTSEYDLAISDYFRRQYSAG---------QSQLTLRYGMNPHQKPA 133
+ + HT+ YD I++Y +++ G Q +YG NPHQK A
Sbjct: 170 KAYEHTANYDAYIANYMNERFNGGFGASKFIVGQKVFDTKYGENPHQKGA 219
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 626,142,708
Number of Sequences: 1657284
Number of extensions: 12010376
Number of successful extensions: 38330
Number of sequences better than 10.0: 31
Number of HSP's better than 10.0 without gapping: 36222
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 38293
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 50000004659
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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