Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0003_F23
(585 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P00439 Cluster: Phenylalanine-4-hydroxylase; n=30; Euka... 302 3e-81
UniRef50_Q8IWU9 Cluster: Tryptophan 5-hydroxylase 2; n=135; Meta... 284 1e-75
UniRef50_P24529 Cluster: Tyrosine 3-monooxygenase; n=61; Coeloma... 265 6e-70
UniRef50_P07101 Cluster: Tyrosine 3-monooxygenase; n=28; Deutero... 254 1e-66
UniRef50_UPI000058423F Cluster: PREDICTED: hypothetical protein;... 252 6e-66
UniRef50_Q9W0K2 Cluster: CG9122-PA; n=4; Endopterygota|Rep: CG91... 243 2e-63
UniRef50_A1Y9J6 Cluster: Tryptophan hydroxylase; n=1; Ciona inte... 242 5e-63
UniRef50_Q9XZD1 Cluster: Tryptophan hydroxylase; n=3; Caenorhabd... 239 3e-62
UniRef50_Q5DGG4 Cluster: SJCHGC01235 protein; n=2; Schistosoma|R... 238 6e-62
UniRef50_Q6WRI4 Cluster: Aromatic amino acid hydroxylase-like; n... 230 2e-59
UniRef50_A6P4D3 Cluster: Tyrosine hydroxylase; n=1; Dugesia japo... 225 5e-58
UniRef50_P18459 Cluster: Tyrosine 3-monooxygenase; n=15; Endopte... 222 6e-57
UniRef50_Q4SDY9 Cluster: Chromosome 13 SCAF14627, whole genome s... 215 6e-55
UniRef50_O17446 Cluster: Tyrosine 3-monooxygenase; n=1; Schistos... 213 2e-54
UniRef50_Q5ZNC6 Cluster: Tyrosine 3-monooxygenase; n=1; Ciona in... 211 8e-54
UniRef50_P90986 Cluster: Tyrosine 3-monooxygenase; n=3; Caenorha... 200 2e-50
UniRef50_Q4THP6 Cluster: Chromosome undetermined SCAF2776, whole... 174 1e-42
UniRef50_Q23A76 Cluster: Biopterin-dependent aromatic amino acid... 163 2e-39
UniRef50_UPI0000F1F407 Cluster: PREDICTED: similar to tryptophan... 156 4e-37
UniRef50_A0C973 Cluster: Chromosome undetermined scaffold_16, wh... 150 3e-35
UniRef50_Q3W6S6 Cluster: Tyrosine 3-monooxygenase; n=3; Actinomy... 136 3e-31
UniRef50_Q5ZS72 Cluster: Phenylalanine-4-hydroxylase; n=4; Legio... 101 2e-20
UniRef50_Q1ISS1 Cluster: Phenylalanine 4-monooxygenase; n=1; Aci... 96 5e-19
UniRef50_A6FEK6 Cluster: Phenylalanine-4-hydroxylase; n=1; Morit... 96 6e-19
UniRef50_Q2S0V6 Cluster: Tryptophan 5-hydroxylase 1; n=1; Salini... 91 1e-17
UniRef50_Q2K9E9 Cluster: Phenylalanine-4-hydroxylase protein; n=... 91 2e-17
UniRef50_Q1VW50 Cluster: Phenylalanine-4-hydroxylase, monomeric ... 85 1e-15
UniRef50_Q0ANJ2 Cluster: Phenylalanine-4-hydroxylase; n=2; Alpha... 84 2e-15
UniRef50_Q1RGM5 Cluster: Phenylalanine-4-hydroxylase; n=1; Ricke... 82 8e-15
UniRef50_Q0PWM2 Cluster: Tyrosine hydroxylase isoform D2,8,9; n=... 81 1e-14
UniRef50_Q9KLB8 Cluster: Phenylalanine-4-hydroxylase; n=19; Vibr... 79 6e-14
UniRef50_P43334 Cluster: Phenylalanine-4-hydroxylase; n=66; Gamm... 79 8e-14
UniRef50_Q98D72 Cluster: Phenylalanine-4-hydroxylase; n=1; Mesor... 75 9e-13
UniRef50_Q124D5 Cluster: Phenylalanine-4-hydroxylase, monomeric ... 75 1e-12
UniRef50_Q8XU39 Cluster: Phenylalanine-4-hydroxylase; n=40; Prot... 75 1e-12
UniRef50_A7CCY2 Cluster: Phenylalanine-4-hydroxylase; n=8; Prote... 74 2e-12
UniRef50_A5P8R6 Cluster: Phenylalanine-4-hydroxylase; n=4; Sphin... 72 9e-12
UniRef50_Q01Z53 Cluster: Aromatic amino acid hydroxylase; n=1; S... 71 3e-11
UniRef50_Q0LGC2 Cluster: Aromatic amino acid hydroxylase; n=3; C... 70 4e-11
UniRef50_Q0C2D1 Cluster: Phenylalanine-4-hydroxylase; n=1; Hypho... 69 8e-11
UniRef50_Q1GTB6 Cluster: Phenylalanine-4-hydroxylase, monomeric ... 66 4e-10
UniRef50_A3HZI9 Cluster: Phenylalanine-4-hydroxylase, monomeric ... 64 2e-09
UniRef50_A7HE07 Cluster: Aromatic amino acid hydroxylase; n=5; C... 63 5e-09
UniRef50_Q9AG78 Cluster: Amino acid hydroxylase; n=1; Streptomyc... 61 2e-08
UniRef50_Q6MHK4 Cluster: Putative uncharacterized protein; n=1; ... 60 5e-08
UniRef50_A3U7E2 Cluster: Phenylalanine 4-monooxygenase; n=13; Ba... 58 2e-07
UniRef50_A4A633 Cluster: Putative uncharacterized protein; n=1; ... 52 8e-06
UniRef50_Q81LM9 Cluster: Phenylalanine-4-hydroxylase, putative; ... 50 5e-05
UniRef50_Q41AV6 Cluster: Aromatic amino acid hydroxylase; n=1; E... 48 1e-04
UniRef50_Q9Z6L3 Cluster: Probable aromatic amino acid hydroxylas... 48 2e-04
UniRef50_A6E752 Cluster: Phenylalanine-4-hydroxylase; n=1; Pedob... 47 3e-04
UniRef50_A6CNR8 Cluster: Phenylalanine 4-monooxygenase; n=1; Bac... 47 3e-04
UniRef50_A3UHY3 Cluster: Phenylalanine-4-hydroxylase; n=1; Ocean... 47 3e-04
UniRef50_Q255G4 Cluster: Aromatic amino acid hyroxylase biopteri... 45 0.001
UniRef50_Q54SH1 Cluster: Putative uncharacterized protein; n=1; ... 36 0.93
UniRef50_Q24990 Cluster: Vsp protein; n=1; Giardia intestinalis|... 34 2.2
UniRef50_Q2W6R1 Cluster: ATP-sensitive inward rectifier potassiu... 34 2.8
UniRef50_A1RK23 Cluster: CRISPR-associated helicase Cas3 family;... 34 2.8
UniRef50_A0YQI6 Cluster: Putative uncharacterized protein; n=1; ... 34 2.8
UniRef50_Q4Z302 Cluster: Putative uncharacterized protein; n=2; ... 33 6.6
UniRef50_Q5EE48 Cluster: Proprotein convertase 6B; n=22; Coeloma... 32 8.7
UniRef50_Q5R3F8 Cluster: Leucine-rich repeat and fibronectin typ... 32 8.7
>UniRef50_P00439 Cluster: Phenylalanine-4-hydroxylase; n=30;
Eukaryota|Rep: Phenylalanine-4-hydroxylase - Homo
sapiens (Human)
Length = 452
Score = 302 bits (742), Expect = 3e-81
Identities = 133/173 (76%), Positives = 150/173 (86%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARRK FADIAYNY+HGQP+P V+Y +EE TWG VF+ L LY THAC E+NH+FPLL +
Sbjct: 156 ARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEK 215
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRDFL GLAFRVFH TQYIRH S+P
Sbjct: 216 YCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKP 275
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGAPD+YIEKLAT +WFT
Sbjct: 276 MYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFT 328
>UniRef50_Q8IWU9 Cluster: Tryptophan 5-hydroxylase 2; n=135;
Metazoa|Rep: Tryptophan 5-hydroxylase 2 - Homo sapiens
(Human)
Length = 490
Score = 284 bits (696), Expect = 1e-75
Identities = 126/172 (73%), Positives = 146/172 (84%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYF D+A YK+GQP+P V+YT+EE TWG VFR+L+ LYPTHAC+E+ FPLL +
Sbjct: 190 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 249
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS RDFLAGLA+RVFH TQYIRH S PL
Sbjct: 250 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 309
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL ADP FAQFSQEIGLASLGA D+ ++KLATC++FT
Sbjct: 310 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFT 361
Score = 34.3 bits (75), Expect = 2.2
Identities = 13/23 (56%), Positives = 19/23 (82%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C EG+L+AYGA LLS
Sbjct: 360 FTIEFGLCKQEGQLRAYGAGLLS 382
>UniRef50_P24529 Cluster: Tyrosine 3-monooxygenase; n=61;
Coelomata|Rep: Tyrosine 3-monooxygenase - Mus musculus
(Mouse)
Length = 498
Score = 265 bits (649), Expect = 6e-70
Identities = 120/172 (69%), Positives = 139/172 (80%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ YK G+P+PHV+YTKEEI TW EV+ L LY THAC+EH F LL
Sbjct: 203 RRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERY 262
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYRED+IPQLEDVS+FLK+ TGF LRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 263 CGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 322
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA D+ IEKL+T +WFT
Sbjct: 323 HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFT 374
Score = 38.7 bits (86), Expect = 0.100
Identities = 18/33 (54%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + VYW ++FG+C G+LKAYGA LLS
Sbjct: 363 EIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLS 395
>UniRef50_P07101 Cluster: Tyrosine 3-monooxygenase; n=28;
Deuterostomia|Rep: Tyrosine 3-monooxygenase - Homo
sapiens (Human)
Length = 528
Score = 254 bits (622), Expect = 1e-66
Identities = 118/172 (68%), Positives = 133/172 (77%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ Y+HG P+P V+YT EEI TW EV+ L LY THAC EH F LL
Sbjct: 233 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERF 292
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 293 SGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 352
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA D+ IEKL+T WFT
Sbjct: 353 HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFT 404
Score = 32.7 bits (71), Expect = 6.6
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + + W ++FG+C G++KAYGA LLS
Sbjct: 393 EIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLS 425
>UniRef50_UPI000058423F Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 522
Score = 252 bits (616), Expect = 6e-66
Identities = 113/172 (65%), Positives = 135/172 (78%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR+ AD+A+ YKHGQP+P V+YT +E+ TWG ++R+L L+PTHACKEH F +L +
Sbjct: 227 RRQRIADVAFKYKHGQPIPRVEYTDDELRTWGLIYRQLKALFPTHACKEHIDAFNILEKE 286
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
Y E IPQ EDVSNFLK TGF LRPVAGLLS+RDFLA LAFRVF +TQY+RH S P+
Sbjct: 287 GLYSESFIPQHEDVSNFLKGKTGFQLRPVAGLLSARDFLASLAFRVFQATQYVRHSSAPM 346
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+TPEPD CHELLGH P+ ADP FAQFSQEIGLASLG D+ I +LAT +WFT
Sbjct: 347 HTPEPDCCHELLGHVPMLADPTFAQFSQEIGLASLGVADEDITRLATLYWFT 398
>UniRef50_Q9W0K2 Cluster: CG9122-PA; n=4; Endopterygota|Rep:
CG9122-PA - Drosophila melanogaster (Fruit fly)
Length = 555
Score = 243 bits (595), Expect = 2e-63
Identities = 115/172 (66%), Positives = 132/172 (76%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR+ F+ IA N+KHG P+P V YT EE+ TWG VF +L LY HA E+ +P L +
Sbjct: 213 RREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKY 272
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDN+PQL+DVS +LK TGF LRPVAG LS RDFL+GLAFRVFH TQYIRH S P
Sbjct: 273 CGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPF 332
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL A+ +FAQFSQEIGLASLGA D IEKLAT ++FT
Sbjct: 333 YTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFT 384
>UniRef50_A1Y9J6 Cluster: Tryptophan hydroxylase; n=1; Ciona
intestinalis|Rep: Tryptophan hydroxylase - Ciona
intestinalis (Transparent sea squirt)
Length = 448
Score = 242 bits (592), Expect = 5e-63
Identities = 108/172 (62%), Positives = 129/172 (75%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR YF +A +++HG +P V+YTK EI TWG+V+++L L+PT AC +H PLL E
Sbjct: 146 RRDYFTKLAMDFRHGDKIPRVEYTKIEIETWGKVYKELMELHPTRACAQHLKNLPLLSEF 205
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
C EDN+PQLED+S FL+ TGF +RP AG LS RDFLAGLAFRVF+ TQYIRHHS P
Sbjct: 206 CKCSEDNVPQLEDISAFLQSRTGFRIRPAAGFLSPRDFLAGLAFRVFNCTQYIRHHSDPY 265
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD+CHE+LGH PL ADP FAQFSQEIGLASLG D KLA C+ +T
Sbjct: 266 YTPEPDICHEILGHVPLLADPEFAQFSQEIGLASLGVSDQDTSKLAGCYLYT 317
>UniRef50_Q9XZD1 Cluster: Tryptophan hydroxylase; n=3;
Caenorhabditis|Rep: Tryptophan hydroxylase -
Caenorhabditis elegans
Length = 532
Score = 239 bits (585), Expect = 3e-62
Identities = 107/172 (62%), Positives = 132/172 (76%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR FA++A NYKHG+P+P +YT E TWG ++RKL L+ HACK+ F LL +
Sbjct: 224 RRMMFAELALNYKHGEPIPRTEYTSSERKTWGIIYRKLRELHKKHACKQFLDNFELLERH 283
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGY E+NIPQLED+ FLK TGF +RPVAG LS+RDFLAGLA+RVF TQY+RHH+ P
Sbjct: 284 CGYSENNIPQLEDICKFLKAKTGFRVRPVAGYLSARDFLAGLAYRVFFCTQYVRHHADPF 343
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD HEL+GH LFADP FAQFSQEIGLASLGA ++ ++KLAT ++F+
Sbjct: 344 YTPEPDTVHELMGHMALFADPDFAQFSQEIGLASLGASEEDLKKLATLYFFS 395
>UniRef50_Q5DGG4 Cluster: SJCHGC01235 protein; n=2; Schistosoma|Rep:
SJCHGC01235 protein - Schistosoma japonicum (Blood
fluke)
Length = 497
Score = 238 bits (583), Expect = 6e-62
Identities = 110/172 (63%), Positives = 131/172 (76%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR FADIA+ YK GQ +P +DYT+ E TWG V+R+LT LY T AC+E LL +
Sbjct: 179 RRMMFADIAFTYKWGQQIPFIDYTETEKMTWGCVYRELTRLYKTTACREFQKNLALLQDE 238
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
GY E ++PQL+ VS+FLK TGF LRPVAG LS+RDFL+GLAFRVF+ TQYIRH P
Sbjct: 239 AGYNEFDLPQLQVVSDFLKARTGFCLRPVAGYLSARDFLSGLAFRVFYCTQYIRHQGDPF 298
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH P+ ADP FA+FSQEIGLASLG DD I+KL+TC++FT
Sbjct: 299 YTPEPDCCHELLGHVPMLADPKFARFSQEIGLASLGTSDDEIKKLSTCYFFT 350
>UniRef50_Q6WRI4 Cluster: Aromatic amino acid hydroxylase-like; n=3;
Leishmania|Rep: Aromatic amino acid hydroxylase-like -
Leishmania major
Length = 453
Score = 230 bits (562), Expect = 2e-59
Identities = 102/173 (58%), Positives = 131/173 (75%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARR+ +A NYK G P+P V+YT+EE W V+ LT LYPTHAC+++N+VFPLL+E
Sbjct: 166 ARRREIVGLAKNYKTGDPIPIVNYTEEENRVWTVVYDHLTRLYPTHACQQYNYVFPLLLE 225
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
N PQL DVS FL + TGFT+RPV GLL+SRDFL LAFRVF+STQYIRH ++P
Sbjct: 226 NGVLSRTKTPQLRDVSEFLNEATGFTVRPVTGLLTSRDFLNALAFRVFYSTQYIRHAAQP 285
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
LYTPEPD+ H+++GH PL +DP FA F+Q IGLASLGA D+ ++KLA +W++
Sbjct: 286 LYTPEPDMVHDIIGHLPLLSDPDFANFTQTIGLASLGASDELLDKLAKVYWYS 338
Score = 34.3 bits (75), Expect = 2.2
Identities = 15/26 (57%), Positives = 20/26 (76%), Gaps = 2/26 (7%)
Frame = +3
Query: 513 VYW--LKFGMCSAEGKLKAYGAWLLS 584
VYW ++FG+CS G+ KAYGA +LS
Sbjct: 334 VYWYSVEFGLCSEGGRRKAYGAGILS 359
>UniRef50_A6P4D3 Cluster: Tyrosine hydroxylase; n=1; Dugesia
japonica|Rep: Tyrosine hydroxylase - Dugesia japonica
(Planarian)
Length = 488
Score = 225 bits (551), Expect = 5e-58
Identities = 104/173 (60%), Positives = 127/173 (73%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
+RR A+IA+N+K+G +P V+Y + E TW E + LT LY +ACKE L E
Sbjct: 190 SRRMEIAEIAFNFKYGDKIPRVEYFESEKETWREAYITLTSLYKDYACKEQLIGIKKLEE 249
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
CGY ++IPQLED+SN+LK +GF LRPVAGLLS+RDFLA LAFRVF TQY RHHS+P
Sbjct: 250 KCGYGPNDIPQLEDISNYLKKTSGFQLRPVAGLLSARDFLASLAFRVFQCTQYTRHHSKP 309
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
L+TPEPD HELLGH P+ +D FA+FSQEIGL SLGA D IE+LAT +WFT
Sbjct: 310 LHTPEPDCIHELLGHVPMLSDAEFAEFSQEIGLCSLGASDSDIERLATLYWFT 362
Score = 32.3 bits (70), Expect = 8.7
Identities = 14/33 (42%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
+I + +YW ++FG+C K+KA+GA LLS
Sbjct: 351 DIERLATLYWFTIEFGLCYENKKIKAFGAGLLS 383
>UniRef50_P18459 Cluster: Tyrosine 3-monooxygenase; n=15;
Endopterygota|Rep: Tyrosine 3-monooxygenase - Drosophila
melanogaster (Fruit fly)
Length = 579
Score = 222 bits (542), Expect = 6e-57
Identities = 100/172 (58%), Positives = 129/172 (75%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ YK+G P+P +DY+ E+ TW VF+ + L P HAC E+ F L +
Sbjct: 281 RRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDE 340
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
+ E +PQL+++S+FL+ TGF+LRP AGLL++RDFLA LAFR+F STQY+RH + P
Sbjct: 341 QIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPY 400
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+TPEPD HELLGH PL ADP+FAQFSQEIGLASLGA D+ IEKL+T +WFT
Sbjct: 401 HTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFT 452
Score = 37.9 bits (84), Expect = 0.17
Identities = 17/33 (51%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + VYW ++FG+C G++KAYGA LLS
Sbjct: 441 EIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLS 473
>UniRef50_Q4SDY9 Cluster: Chromosome 13 SCAF14627, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 13 SCAF14627, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 488
Score = 215 bits (525), Expect = 6e-55
Identities = 112/199 (56%), Positives = 132/199 (66%), Gaps = 27/199 (13%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK D+A+ Y+HG+ +P V+YT+EEI TW EV+ L LY THAC EH F LL ++
Sbjct: 167 RRKMIGDVAFRYRHGESIPRVEYTEEEIGTWREVYLTLRDLYATHACSEHLEAFRLLEKH 226
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGY DNIPQLEDVS FLK+ TGFTLRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 227 CGYSPDNIPQLEDVSCFLKERTGFTLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 286
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIG----------------------LASL--- 468
++PEPD HELLGH P+ A+ FAQFSQ G L SL
Sbjct: 287 HSPEPDCVHELLGHVPMLANSTFAQFSQVRGRQRTFCPLRLSYVFANSPWIHPLQSLGLA 346
Query: 469 --GAPDDYIEKLATCFWFT 519
GA D+ IEKL+T +WFT
Sbjct: 347 SLGASDEDIEKLSTLYWFT 365
Score = 33.9 bits (74), Expect = 2.8
Identities = 14/33 (42%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
+I + +YW +++G+C G++KAYGA LLS
Sbjct: 354 DIEKLSTLYWFTVEYGLCKQNGEVKAYGAGLLS 386
>UniRef50_O17446 Cluster: Tyrosine 3-monooxygenase; n=1; Schistosoma
mansoni|Rep: Tyrosine 3-monooxygenase - Schistosoma
mansoni (Blood fluke)
Length = 465
Score = 213 bits (521), Expect = 2e-54
Identities = 94/172 (54%), Positives = 126/172 (73%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR+ A IA+ YK+G +P V+YTKEEI TWG VF K+ ++ + AC+E+ F LL +
Sbjct: 166 RREAIAKIAFQYKYGDRIPEVEYTKEEIETWGLVFTKMKAVHASRACREYIDGFQLLEKY 225
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
C Y ++IPQL+ + F+ +GF +RPVAGL+S +DFLA LAFRVF TQYIRHHSRP+
Sbjct: 226 CNYNSESIPQLQTICEFMHRTSGFRIRPVAGLVSPKDFLASLAFRVFQCTQYIRHHSRPM 285
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+TPEPD HEL+GH P+ + FA FSQE+GLASLGA ++ I +L+T +WFT
Sbjct: 286 HTPEPDCIHELIGHMPMLVNRQFADFSQELGLASLGASEEEITRLSTLYWFT 337
>UniRef50_Q5ZNC6 Cluster: Tyrosine 3-monooxygenase; n=1; Ciona
intestinalis|Rep: Tyrosine 3-monooxygenase - Ciona
intestinalis (Transparent sea squirt)
Length = 429
Score = 211 bits (516), Expect = 8e-54
Identities = 93/172 (54%), Positives = 120/172 (69%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR Y ++ A+ YKHG +P VDYT E+ TW V++ L L+ THACK + F L +
Sbjct: 156 RRNYISNTAHFYKHGTDIPTVDYTNEDRQTWSVVYKTLKRLHATHACKVYKDNFQRLEKE 215
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGY + IPQL+ VS FLK+ TGF L+P G+++ RDFLA LAF+VF TQYIRH + P+
Sbjct: 216 CGYSPNKIPQLQTVSEFLKEQTGFKLQPAPGIITPRDFLASLAFKVFQCTQYIRHPASPM 275
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHEL+GH P+ DP FA +SQ+IGLASLG D I KLA +WFT
Sbjct: 276 HSPEPDCCHELIGHIPMLLDPTFALYSQQIGLASLGVSDSDITKLAALYWFT 327
Score = 32.3 bits (70), Expect = 8.7
Identities = 14/33 (42%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
+I+ + +YW ++FG+C LKAYGA L+S
Sbjct: 316 DITKLAALYWFTVEFGLCKENNVLKAYGAGLMS 348
>UniRef50_P90986 Cluster: Tyrosine 3-monooxygenase; n=3;
Caenorhabditis|Rep: Tyrosine 3-monooxygenase -
Caenorhabditis elegans
Length = 454
Score = 200 bits (488), Expect = 2e-50
Identities = 92/172 (53%), Positives = 119/172 (69%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARRK+ D A +K G + +VDYT+EE TW V+ KL L+ +H C + +L E
Sbjct: 153 ARRKFLNDQALEFKFGDEIGYVDYTEEEHATWKAVYEKLGDLHLSHTCAVYRQNLKILQE 212
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
D IPQ+ DV+ FL+ TGF LRP +GLLS+RDFLA LAFRVF +T Y+RHH P
Sbjct: 213 EKVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSP 272
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWF 516
++PEPD+ HELLGH P+F+DP AQ SQ+IGL SLGA D++IEKL+T +WF
Sbjct: 273 HHSPEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLSTVYWF 324
Score = 35.9 bits (79), Expect = 0.70
Identities = 17/32 (53%), Positives = 22/32 (68%), Gaps = 2/32 (6%)
Frame = +3
Query: 495 ISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
I + VYW ++FG+C +GKLKA GA LLS
Sbjct: 315 IEKLSTVYWFIVEFGLCKEDGKLKAIGAGLLS 346
>UniRef50_Q4THP6 Cluster: Chromosome undetermined SCAF2776, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF2776,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 218
Score = 174 bits (424), Expect = 1e-42
Identities = 87/151 (57%), Positives = 105/151 (69%), Gaps = 26/151 (17%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYF ++A NYK GQP+P V+YT EE+ TWG VFR+LT LYPTHAC+E+ PLL ++
Sbjct: 68 RRKYFVEVAMNYKFGQPIPRVEYTPEEVRTWGVVFRELTKLYPTHACREYLKNLPLLSKH 127
Query: 184 CGYREDNIPQLEDVSNFLK--------------------------DCTGFTLRPVAGLLS 285
CGYREDN+PQLEDVS FL+ + +GFT+RPVAG LS
Sbjct: 128 CGYREDNVPQLEDVSLFLRGPLDVVRNSQSDKVAVTVTRGPWCVPERSGFTVRPVAGYLS 187
Query: 286 SRDFLAGLAFRVFHSTQYIRHHSRPLYTPEP 378
RDFLAGLA+RVF+ TQYIRH + PLYTPEP
Sbjct: 188 PRDFLAGLAYRVFNCTQYIRHSTDPLYTPEP 218
>UniRef50_Q23A76 Cluster: Biopterin-dependent aromatic amino acid
hydroxylase family protein; n=2; Tetrahymena thermophila
SB210|Rep: Biopterin-dependent aromatic amino acid
hydroxylase family protein - Tetrahymena thermophila
SB210
Length = 448
Score = 163 bits (397), Expect = 2e-39
Identities = 75/172 (43%), Positives = 108/172 (62%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR Y A ++ ++ GQP+P ++YT++E TW ++ KL+ + +N+ L
Sbjct: 172 RRDYIAQVSKSHILGQPIPILEYTEQENQTWRTIYNKLSSYHKDLCTDRYNYNKRQLERE 231
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
G ++ IPQL D+ +L+ T F ++ G+LS R+FL LA RVF STQYIRHH
Sbjct: 232 LGI-QNQIPQLRDLDAYLRQKTNFKIKAAHGILSQREFLNALAHRVFFSTQYIRHHKTVE 290
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD+ HE++GH P+FADP A SQEIGL S+GA D+ + +L +WFT
Sbjct: 291 YTPEPDIVHEVVGHIPMFADPVVADISQEIGLLSIGANDEQLRRLGNIYWFT 342
Score = 33.5 bits (73), Expect = 3.8
Identities = 13/25 (52%), Positives = 18/25 (72%), Gaps = 2/25 (8%)
Frame = +3
Query: 513 VYW--LKFGMCSAEGKLKAYGAWLL 581
+YW L+FG C GK+KAYGA ++
Sbjct: 338 IYWFTLEFGACKENGKMKAYGAGII 362
>UniRef50_UPI0000F1F407 Cluster: PREDICTED: similar to tryptophan
hydroxylase D1; n=7; Danio rerio|Rep: PREDICTED: similar
to tryptophan hydroxylase D1 - Danio rerio
Length = 488
Score = 156 bits (378), Expect = 4e-37
Identities = 71/86 (82%), Positives = 76/86 (88%)
Frame = +1
Query: 247 TGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADP 426
TGFT+RPVAG LS RDFLAGLAFRVFH TQY+RH S PLYTPEPD CHELLGH PL A+P
Sbjct: 363 TGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEP 422
Query: 427 AFAQFSQEIGLASLGAPDDYIEKLAT 504
+FAQFSQEIGLASLGA DD I+KLAT
Sbjct: 423 SFAQFSQEIGLASLGASDDSIQKLAT 448
>UniRef50_A0C973 Cluster: Chromosome undetermined scaffold_16, whole
genome shotgun sequence; n=4; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_16,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 431
Score = 150 bits (363), Expect = 3e-35
Identities = 73/172 (42%), Positives = 103/172 (59%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RR+ A ++ + G+P+P+++YT++E TW +++ L + + + IEN
Sbjct: 148 RREEIAKLSQQHLIGEPVPYINYTEQEEVTWKKIYSILRERVEKVMSQRYLRNL-VKIEN 206
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
+ IPQL D+ +LK TGF ++ G+LS R+FL L RVF TQYIRHHS P
Sbjct: 207 ALGFKYKIPQLRDIDAYLKAETGFRIKATHGILSQREFLNALGHRVFCCTQYIRHHSTPE 266
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD+ HEL+GH PLFAD A SQEIG+ S G + +L T +WFT
Sbjct: 267 YTPEPDIVHELVGHVPLFADKEVADLSQEIGILSCGTEQKDLSRLGTLYWFT 318
>UniRef50_Q3W6S6 Cluster: Tyrosine 3-monooxygenase; n=3;
Actinomycetales|Rep: Tyrosine 3-monooxygenase - Frankia
sp. EAN1pec
Length = 296
Score = 136 bits (330), Expect = 3e-31
Identities = 74/174 (42%), Positives = 97/174 (55%), Gaps = 1/174 (0%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARR A++A ++ GQP+P V YT+ E W V KL Y AC E F
Sbjct: 37 ARRNQIAELALRWRPGQPVPRVAYTEAEHAVWRLVTGKLALAYRGCACAE----FLRGAA 92
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
G D IPQL++VS L + TGF P AGL+ R+F LA VFH+TQY+RHH+ P
Sbjct: 93 RMGLPTDRIPQLDEVSGPLSELTGFRYVPAAGLVGLREFYGSLADGVFHATQYLRHHTVP 152
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
YTPEPD+ HE++GHA A FA + G A+ A D ++ ++ FWFT
Sbjct: 153 FYTPEPDIIHEVVGHANALASDRFAALYRAAGEAARRAESADTLQFISKVFWFT 206
>UniRef50_Q5ZS72 Cluster: Phenylalanine-4-hydroxylase; n=4;
Legionella pneumophila|Rep: Phenylalanine-4-hydroxylase
- Legionella pneumophila subsp. pneumophila (strain
Philadelphia 1 /ATCC 33152 / DSM 7513)
Length = 281
Score = 101 bits (241), Expect = 2e-20
Identities = 55/152 (36%), Positives = 76/152 (50%)
Frame = +1
Query: 64 VDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKD 243
VDY+ +E W +F + L P AC E F ++ G IPQL +VS LK
Sbjct: 27 VDYSAQENRIWNILFERQLKLLPGRACDE----FLSGLQTLGLNSSTIPQLPEVSERLKA 82
Query: 244 CTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFAD 423
TG+ + PVA L+S+R+F LA + F + +IR Y EPD+ HEL GH P+ D
Sbjct: 83 KTGWQVAPVAALISAREFFELLAEKYFPAATFIRSEEELDYVQEPDIFHELFGHCPMLTD 142
Query: 424 PAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+A+F + L P+ L FWFT
Sbjct: 143 RVYAEFVHDYACKVLTFPEQDWPLLQRMFWFT 174
>UniRef50_Q1ISS1 Cluster: Phenylalanine 4-monooxygenase; n=1;
Acidobacteria bacterium Ellin345|Rep: Phenylalanine
4-monooxygenase - Acidobacteria bacterium (strain
Ellin345)
Length = 250
Score = 96.3 bits (229), Expect = 5e-19
Identities = 56/155 (36%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Frame = +1
Query: 61 HVD-YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFL 237
H D Y+ E TW ++ + THACKE+ +L G R + +P + D++ L
Sbjct: 20 HYDQYSDVEHGTWKTLYERRMEQLSTHACKEYLEGLRVL----GMRAERMPVISDINKTL 75
Query: 238 KDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLF 417
+ T + L PV+G L R F LA RVF T YIR YTPEPD+ H++ GH P+
Sbjct: 76 QTRTNWMLLPVSGFLPGRTFFDLLAARVFPVTTYIRKPDSLDYTPEPDIFHDIFGHVPMH 135
Query: 418 ADPAFAQFSQEIG-LASLGAPDDYIEKLATCFWFT 519
A FA + Q +A D E+L FW+T
Sbjct: 136 AHKVFADYLQAFAQIARQITNDADQERLGRLFWYT 170
>UniRef50_A6FEK6 Cluster: Phenylalanine-4-hydroxylase; n=1;
Moritella sp. PE36|Rep: Phenylalanine-4-hydroxylase -
Moritella sp. PE36
Length = 272
Score = 95.9 bits (228), Expect = 6e-19
Identities = 59/168 (35%), Positives = 80/168 (47%), Gaps = 2/168 (1%)
Frame = +1
Query: 22 DIAYNYKHGQPLPH--VDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYR 195
D+ Y QP H ++Y+ EE TW ++ + T + AC E F IE
Sbjct: 8 DLTPKYVSHQPDQHGYINYSDEEHNTWATLYNRQTEIIKDRACDE----FIAGIELLQMG 63
Query: 196 EDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPE 375
D IPQL D++ LK TG+ + V L+ F LA + F + +IR + Y E
Sbjct: 64 ADRIPQLPDINRKLKKLTGWQVENVPALIGFERFFELLATKRFPAATFIRTKADIDYIQE 123
Query: 376 PDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
PD+ HEL GH PL + A+A FSQ G L A LA +WFT
Sbjct: 124 PDIFHELFGHCPLLTNQAYADFSQHYGELGLKADKADRPMLARLYWFT 171
>UniRef50_Q2S0V6 Cluster: Tryptophan 5-hydroxylase 1; n=1;
Salinibacter ruber DSM 13855|Rep: Tryptophan
5-hydroxylase 1 - Salinibacter ruber (strain DSM 13855)
Length = 278
Score = 91.5 bits (217), Expect = 1e-17
Identities = 52/158 (32%), Positives = 75/158 (47%)
Frame = +1
Query: 46 GQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDV 225
G + + DY E+ TW + + P AC+ + +L G D IP L D+
Sbjct: 43 GDEIEYPDYPDEDHETWQILVERQMEQLPGRACEAYMRGQDVL----GLEGDRIPDLADL 98
Query: 226 SNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGH 405
S L + TG+ + V GL+ ++F + L+ R F ST Y+R YTP PD H++ GH
Sbjct: 99 SRRLNEETGWEVANVPGLIHEKNFFSLLSQRKFPSTNYVRGREELDYTPAPDCFHDIFGH 158
Query: 406 APLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
P+ P FA F Q G A+ A +L WFT
Sbjct: 159 MPMLTQPEFADFYQLYGQAAQNAEGADRPRLERFHWFT 196
>UniRef50_Q2K9E9 Cluster: Phenylalanine-4-hydroxylase protein; n=2;
Rhizobium|Rep: Phenylalanine-4-hydroxylase protein -
Rhizobium etli (strain CFN 42 / ATCC 51251)
Length = 263
Score = 91.1 bits (216), Expect = 2e-17
Identities = 54/164 (32%), Positives = 77/164 (46%)
Frame = +1
Query: 28 AYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNI 207
+Y K P DYT EE WGE++R+ L AC+E+ LL G R + +
Sbjct: 6 SYTAKLPGPDGLYDYTPEEDAIWGELYRRQMKLLADKACQEYLDGVKLL----GLRPEKV 61
Query: 208 PQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVC 387
PQL DV+ L + TGF + V L+ F L+ F ++R Y EPD+
Sbjct: 62 PQLLDVNRRLNETTGFGVEGVPALIPPSRFYELLSQGKFPLATFLRRREHIDYIEEPDLF 121
Query: 388 HELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
HE+ GH PL + ++A F + G ++ Y L FWFT
Sbjct: 122 HEVFGHCPLLTNQSYANFVRHFGETAMRLGKGYSWHLFRIFWFT 165
>UniRef50_Q1VW50 Cluster: Phenylalanine-4-hydroxylase, monomeric
form; n=1; Psychroflexus torquis ATCC 700755|Rep:
Phenylalanine-4-hydroxylase, monomeric form -
Psychroflexus torquis ATCC 700755
Length = 242
Score = 85.0 bits (201), Expect = 1e-15
Identities = 51/157 (32%), Positives = 80/157 (50%), Gaps = 7/157 (4%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEH----NHVFPLLIENCGYREDNIPQLEDVSNFL 237
YTK++++ W +F + P A K + H+ P+L D IP E ++++
Sbjct: 7 YTKDDLWVWNTLFNRQKENIPGKASKSYIDALEHMSPVL------NADEIPDFEKINSWF 60
Query: 238 KDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLF 417
K T + L+ V GL+ +F LA R F S+ ++R Y EPDV H++ GH PL
Sbjct: 61 KTETQWELQVVPGLIPVEEFFKLLAERKFCSSTWLRSKDSLDYLEEPDVFHDIFGHVPLL 120
Query: 418 ADPAFAQFSQE---IGLASLGAPDDYIEKLATCFWFT 519
+DP F++F E +G LG + I+ L +WFT
Sbjct: 121 SDPVFSEFVCEFGKLGCQFLGDTEKLIQ-LQRLYWFT 156
>UniRef50_Q0ANJ2 Cluster: Phenylalanine-4-hydroxylase; n=2;
Alphaproteobacteria|Rep: Phenylalanine-4-hydroxylase -
Maricaulis maris (strain MCS10)
Length = 293
Score = 84.2 bits (199), Expect = 2e-15
Identities = 50/151 (33%), Positives = 73/151 (48%), Gaps = 1/151 (0%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
YT E W ++ + + A EH +L N E IP V+ L+ T
Sbjct: 26 YTAGEHAIWTTLYERQMGVLKGRAAPEHFAGLDMLNLN----EGGIPDFRRVNEKLEKLT 81
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+T+ V GL+ +DF LA R F S ++IR Y PEPD+ H++ GH PL P
Sbjct: 82 GWTVVTVPGLIPEKDFYEHLANRRFVSGRFIRDGETLDYLPEPDIFHDVFGHVPLLTQPV 141
Query: 430 FAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
FA + Q G L + + D I+ +A +W+T
Sbjct: 142 FADYMQAYGKGGLRSLEFDAIKHMARLYWYT 172
>UniRef50_Q1RGM5 Cluster: Phenylalanine-4-hydroxylase; n=1;
Rickettsia bellii RML369-C|Rep:
Phenylalanine-4-hydroxylase - Rickettsia bellii (strain
RML369-C)
Length = 246
Score = 82.2 bits (194), Expect = 8e-15
Identities = 50/151 (33%), Positives = 73/151 (48%), Gaps = 1/151 (0%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
+T+ + W +F + T L A E IE D IP+ +++ L T
Sbjct: 18 FTETDHEIWKTLFNRHTELLKNRATNEIVEG----IEKLKICNDRIPKFTELNRILMKET 73
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
F++ PV G + F LA R F ST +IR + Y EPD+ H++ GH PL +P
Sbjct: 74 NFSIIPVKGFIPEDLFFKFLAERKFPSTCFIRQPHQLDYLEEPDIFHDVFGHVPLLVNPV 133
Query: 430 FAQFSQEIGLASLGAPDDYIEKLATC-FWFT 519
FA F Q+ GL L A + + K A+ +WFT
Sbjct: 134 FADFMQQFGLKGLEAIEAGMLKFASALYWFT 164
>UniRef50_Q0PWM2 Cluster: Tyrosine hydroxylase isoform D2,8,9; n=31;
Eutheria|Rep: Tyrosine hydroxylase isoform D2,8,9 - Homo
sapiens (Human)
Length = 407
Score = 81.4 bits (192), Expect = 1e-14
Identities = 40/77 (51%), Positives = 48/77 (62%)
Frame = +1
Query: 289 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 468
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 207 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 266
Query: 469 GAPDDYIEKLATCFWFT 519
GA D+ IEKL+T +WFT
Sbjct: 267 GASDEEIEKLSTLYWFT 283
Score = 51.2 bits (117), Expect = 2e-05
Identities = 21/41 (51%), Positives = 27/41 (65%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHL 126
RRK A+IA+ Y+HG P+P V+YT EEI TW L H+
Sbjct: 206 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHV 246
Score = 36.3 bits (80), Expect = 0.53
Identities = 16/33 (48%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + +YW ++FG+C G++KAYGA LLS
Sbjct: 272 EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLS 304
>UniRef50_Q9KLB8 Cluster: Phenylalanine-4-hydroxylase; n=19;
Vibrionaceae|Rep: Phenylalanine-4-hydroxylase - Vibrio
cholerae
Length = 289
Score = 79.4 bits (187), Expect = 6e-14
Identities = 47/162 (29%), Positives = 74/162 (45%), Gaps = 3/162 (1%)
Frame = +1
Query: 43 HGQPLP---HVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQ 213
H +P+ H+D+ ++E W E+ + + T AC+ + +L D +PQ
Sbjct: 30 HSKPVSEHGHIDWDQDEHAVWHELITRQQEVVKTRACQAYLDGLNML----NLPTDRLPQ 85
Query: 214 LEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHE 393
L +++ L+ TG+ + PV L+S F A LA + F ++R Y EPD HE
Sbjct: 86 LPEINRVLQRETGWQVEPVPALISFDRFFALLADKKFPVATFLRRREEFDYLQEPDFFHE 145
Query: 394 LLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+ GH + P FA F+ G A LA +WFT
Sbjct: 146 VYGHCAMLTHPDFAAFTHVYGQLGAKATPKERSYLARLYWFT 187
>UniRef50_P43334 Cluster: Phenylalanine-4-hydroxylase; n=66;
Gammaproteobacteria|Rep: Phenylalanine-4-hydroxylase -
Pseudomonas aeruginosa
Length = 262
Score = 79.0 bits (186), Expect = 8e-14
Identities = 45/152 (29%), Positives = 71/152 (46%)
Frame = +1
Query: 64 VDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKD 243
+ Y + E W + + + AC+E+ IE G + IPQL++++ L+
Sbjct: 17 IHYPETEHQVWNTLITRQLKVIEGRACQEYLDG----IEQLGLPHERIPQLDEINRVLQA 72
Query: 244 CTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFAD 423
TG+ + V L+ + F LA + F +IR Y EPD+ HE+ GH PL +
Sbjct: 73 TTGWRVARVPALIPFQTFFELLASQQFPVATFIRTPEELDYLQEPDIFHEIFGHCPLLTN 132
Query: 424 PAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
P FA+F+ G L A + LA +W T
Sbjct: 133 PWFAEFTHTYGKLGLKASKEERVFLARLYWMT 164
>UniRef50_Q98D72 Cluster: Phenylalanine-4-hydroxylase; n=1;
Mesorhizobium loti|Rep: Phenylalanine-4-hydroxylase -
Rhizobium loti (Mesorhizobium loti)
Length = 275
Score = 75.4 bits (177), Expect = 9e-13
Identities = 52/156 (33%), Positives = 76/156 (48%), Gaps = 5/156 (3%)
Frame = +1
Query: 67 DYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDC 246
DY+ EE W + + T L T H+++ +E G D IP EDVS L+
Sbjct: 33 DYSDEEQAVWRTLCDRQTKL--TRKLAHHSYLDG--VEKLGLL-DRIPDFEDVSTKLRKL 87
Query: 247 TGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADP 426
TG+ + V GL+ + F LA R F T ++R Y EPD+ H+ GH P+ + P
Sbjct: 88 TGWEIIAVPGLIPAAPFFDHLANRRFPVTNWLRTRQELDYIVEPDMFHDFFGHVPVLSQP 147
Query: 427 AFAQFSQEIG-----LASLGAPDDYIEKLATCFWFT 519
FA F Q G + +LG D+ I +L +W+T
Sbjct: 148 VFADFMQMYGKKAGDIIALGG-DEMITRL---YWYT 179
>UniRef50_Q124D5 Cluster: Phenylalanine-4-hydroxylase, monomeric
form; n=8; Burkholderiales|Rep:
Phenylalanine-4-hydroxylase, monomeric form -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 292
Score = 74.9 bits (176), Expect = 1e-12
Identities = 50/157 (31%), Positives = 75/157 (47%), Gaps = 1/157 (0%)
Frame = +1
Query: 52 PLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSN 231
P + YT + + ++++ + L P AC E PLL G +E IP+ E+++
Sbjct: 38 PQNYAAYTAADHDIYHRLYQRQSALVPGLACDEFIAALPLL----GAKE-RIPRFEEINE 92
Query: 232 FLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAP 411
L T + + V GL+ F LA R F T ++R + Y EPDV H+L GH P
Sbjct: 93 RLYKATRWEIVAVPGLIPEVPFFTLLANRKFPVTDWLRTPAEFDYIVEPDVFHDLFGHVP 152
Query: 412 LFADPAFAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
L +P FA Q G L A E+L+ +W+T
Sbjct: 153 LLFNPVFADHMQAYGAGGLKAHALGACEQLSRLYWYT 189
>UniRef50_Q8XU39 Cluster: Phenylalanine-4-hydroxylase; n=40;
Proteobacteria|Rep: Phenylalanine-4-hydroxylase -
Ralstonia solanacearum (Pseudomonas solanacearum)
Length = 313
Score = 74.9 bits (176), Expect = 1e-12
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 1/151 (0%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
YT + TW ++ + L P AC E F + G + +P + ++ L T
Sbjct: 52 YTAADHATWRTLYDRQEALLPGRACDE----FLQGLSTLGMSREGVPSFDRLNETLMRAT 107
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ + V GL+ F LA R F ++ ++R + Y EPD H++ GH PL +P
Sbjct: 108 GWQIVAVPGLVPDEVFFEHLANRRFPASWWMRRPDQLDYLQEPDGFHDIFGHVPLLINPV 167
Query: 430 FAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
FA + Q G L A ++ LA +W+T
Sbjct: 168 FADYMQAYGQGGLKAARLGALDMLARLYWYT 198
>UniRef50_A7CCY2 Cluster: Phenylalanine-4-hydroxylase; n=8;
Proteobacteria|Rep: Phenylalanine-4-hydroxylase -
Ralstonia pickettii 12D
Length = 349
Score = 74.1 bits (174), Expect = 2e-12
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 1/151 (0%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
YT + TW ++ + L P C E F + G D +P + ++ L T
Sbjct: 88 YTAADHATWRTLYDRQEALLPGRVCDE----FLQGLSTLGMSRDAVPSFDQLNETLMRAT 143
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ + V GL+ F LA R F ++ ++R + Y EPD H++ GH PL +P
Sbjct: 144 GWQIVAVPGLVPDEVFFDHLANRRFPASWWMRRPDQLDYLQEPDCFHDIFGHVPLLINPI 203
Query: 430 FAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
FA + + G L A ++ LA +W+T
Sbjct: 204 FADYMEAYGKGGLKAARLGQLDMLARLYWYT 234
>UniRef50_A5P8R6 Cluster: Phenylalanine-4-hydroxylase; n=4;
Sphingomonadales|Rep: Phenylalanine-4-hydroxylase -
Erythrobacter sp. SD-21
Length = 313
Score = 72.1 bits (169), Expect = 9e-12
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 1/151 (0%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
Y E+ W ++F++ + P A F E +P+ +S L T
Sbjct: 44 YDSEDDAIWNDLFKRQMEMLPGRAAT----AFMEGTEKLDLGRGGVPEFGKLSEELDKLT 99
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+++ PV L+ F LA R F + +IR Y EPDV H++ GH P+ DP
Sbjct: 100 GWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLTDPV 159
Query: 430 FAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
+A + QE G A A + ++ L + +W+T
Sbjct: 160 YADYMQEYGKAGWKAMRYNRLKALGSLYWYT 190
>UniRef50_Q01Z53 Cluster: Aromatic amino acid hydroxylase; n=1;
Solibacter usitatus Ellin6076|Rep: Aromatic amino acid
hydroxylase - Solibacter usitatus (strain Ellin6076)
Length = 306
Score = 70.5 bits (165), Expect = 3e-11
Identities = 41/126 (32%), Positives = 64/126 (50%)
Frame = +1
Query: 58 PHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFL 237
P+ Y+KE W ++F+++ + +A N F +E D +P+L DV+ L
Sbjct: 32 PYELYSKENHEAWQKLFKRIHTRWERYA----NDHFLRGVEALELPHDRVPRLTDVNRRL 87
Query: 238 KDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLF 417
+ TGF +PV+G + F L R F +T IR R Y PEPD+ H++ GH P+
Sbjct: 88 QPLTGFQAKPVSGYVPGFLFFDCLRRREFPTTITIRPADRMDYLPEPDIFHDVAGHVPMH 147
Query: 418 ADPAFA 435
+ FA
Sbjct: 148 TERQFA 153
>UniRef50_Q0LGC2 Cluster: Aromatic amino acid hydroxylase; n=3;
Chloroflexi (class)|Rep: Aromatic amino acid hydroxylase
- Herpetosiphon aurantiacus ATCC 23779
Length = 247
Score = 70.1 bits (164), Expect = 4e-11
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 2/157 (1%)
Frame = +1
Query: 55 LPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNF 234
L ++Y +E+ TW ++++ L HACK +F I+ ++P VS++
Sbjct: 8 LSRLEYPQEDHDTWAALWQRQMPLAQQHACK----LFLEGIDILNLDRTHLPDPLAVSDY 63
Query: 235 LKDCTGFTLRPVAGL-LSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAP 411
L TG+ L L ++ +A R F T YIR +TP PD+ HE GH P
Sbjct: 64 LNTLTGWALGDAQNAYLGPTEWFEHIAERRFPVTNYIRRPHELEFTPLPDLFHEYFGHLP 123
Query: 412 LFADPAFAQFSQEIGLASLGAPDDYIE-KLATCFWFT 519
F + FA +Q G L A D+ + +A +WF+
Sbjct: 124 AFTNREFADIAQLFGPLYLSAKDERQQLGIARIWWFS 160
>UniRef50_Q0C2D1 Cluster: Phenylalanine-4-hydroxylase; n=1;
Hyphomonas neptunium ATCC 15444|Rep:
Phenylalanine-4-hydroxylase - Hyphomonas neptunium
(strain ATCC 15444)
Length = 293
Score = 68.9 bits (161), Expect = 8e-11
Identities = 45/151 (29%), Positives = 67/151 (44%), Gaps = 1/151 (0%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
Y+ E W +FR+ + A K V + IP + +S+ L+ T
Sbjct: 28 YSPAEHDRWDRLFRRQKEIATGRASK----VALDAMHKLELSPSGIPHMGRLSDKLEKIT 83
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ + PVA L+ F LA R F + +IR Y EPD+ H++ GH P+ ADP
Sbjct: 84 GWRVVPVAELVPDEVFFDHLANRRFPAGAFIRPEEEFDYLQEPDIFHDIFGHVPMLADPV 143
Query: 430 FAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
FA F + G A + LA +W+T
Sbjct: 144 FADFMEAYGKGGQRAMRLGQLHNLARLYWYT 174
>UniRef50_Q1GTB6 Cluster: Phenylalanine-4-hydroxylase, monomeric
form; n=2; Sphingomonadaceae|Rep:
Phenylalanine-4-hydroxylase, monomeric form -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 290
Score = 66.5 bits (155), Expect = 4e-10
Identities = 41/147 (27%), Positives = 69/147 (46%), Gaps = 4/147 (2%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
+T E+ TW +F + + +AC+ LL +P +++ LK +
Sbjct: 27 FTPEQHRTWRTLFDRQSAAMGGYACRAFLDGLGLLRR----LRPGVPDFAELNALLKPAS 82
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ + V G + + F LA R F + ++R + Y+ EPD+ H++ GH P+ A+PA
Sbjct: 83 GWEVVAVPGWIPNAPFFEHLANRRFPAANFVRPPEQIAYSEEPDMFHDIFGHVPMLANPA 142
Query: 430 FAQFSQEIGLASLGA----PDDYIEKL 498
F F G A L A DY+ +L
Sbjct: 143 FGDFLVAYGEAGLRAESLGASDYLGRL 169
>UniRef50_A3HZI9 Cluster: Phenylalanine-4-hydroxylase, monomeric
form; n=2; Flexibacteraceae|Rep:
Phenylalanine-4-hydroxylase, monomeric form -
Algoriphagus sp. PR1
Length = 259
Score = 64.5 bits (150), Expect = 2e-09
Identities = 41/152 (26%), Positives = 71/152 (46%), Gaps = 2/152 (1%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
YT E+ W +F + P A K + +E G+ D I ED++ L T
Sbjct: 25 YTSEDFKVWKILFERQMPNLPKAASKAYLDG----VEIVGFSADRIANFEDLNQILAKTT 80
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ ++ V GL+ F L R F S+ ++R + Y EPD+ H+ H P+ +
Sbjct: 81 GWEVQVVPGLIDDDLFFGLLNNRRFPSSTWLRKMEQLDYLQEPDMFHDAFAHMPMLTNQP 140
Query: 430 FAQFSQEI-GLASLGAPDDY-IEKLATCFWFT 519
+ F +++ G+A + + I+ L+ +WFT
Sbjct: 141 YVDFLEKLSGIALKHINNPWAIQLLSRIYWFT 172
>UniRef50_A7HE07 Cluster: Aromatic amino acid hydroxylase; n=5;
Cystobacterineae|Rep: Aromatic amino acid hydroxylase -
Anaeromyxobacter sp. Fw109-5
Length = 528
Score = 62.9 bits (146), Expect = 5e-09
Identities = 40/141 (28%), Positives = 65/141 (46%), Gaps = 3/141 (2%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
YT + W + R+LT H + + +E G + IP+L++++ L
Sbjct: 27 YTPRDHAVWRHILRRLT----AHLRSRAHPRYLAGLEATGIDVERIPRLDEMNERLARA- 81
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ V G + F + RV IR H YTP PD+ HE GHAP ADP
Sbjct: 82 GWAAVAVRGFIPPAVFTELQSRRVLAIAADIRTHEHIEYTPAPDIVHESAGHAPFIADPT 141
Query: 430 FAQF---SQEIGLASLGAPDD 483
+A++ + E+G ++ + +D
Sbjct: 142 YAEYLRRAGEVGFRAIASAED 162
>UniRef50_Q9AG78 Cluster: Amino acid hydroxylase; n=1; Streptomyces
verticillus|Rep: Amino acid hydroxylase - Streptomyces
verticillus
Length = 244
Score = 60.9 bits (141), Expect = 2e-08
Identities = 44/151 (29%), Positives = 63/151 (41%), Gaps = 3/151 (1%)
Frame = +1
Query: 43 HGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLED 222
HG P Y + W ++R+ L P A + LL G D++P L
Sbjct: 4 HGVPPVQEPYGPVDQEVWRHLYRQQAELVPAAAPPLYLEGLALL----GLPTDHVPDLGQ 59
Query: 223 VSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLG 402
V+ L +G+T V GL+ +F L R F T +R + PD+ H+L G
Sbjct: 60 VNERLSAVSGWTCVAVDGLVKGPEFFDMLLHRRFPVTSRMRAPEELRFARLPDLFHDLFG 119
Query: 403 HAPLFADPAFAQFSQE---IGLASLGAPDDY 486
H P A A QE IG+ G P+D+
Sbjct: 120 HGPYLAHARTADLYQEFGRIGVRCAGRPEDF 150
>UniRef50_Q6MHK4 Cluster: Putative uncharacterized protein; n=1;
Bdellovibrio bacteriovorus|Rep: Putative uncharacterized
protein - Bdellovibrio bacteriovorus
Length = 580
Score = 59.7 bits (138), Expect = 5e-08
Identities = 36/127 (28%), Positives = 59/127 (46%)
Frame = +1
Query: 70 YTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCT 249
YT + W V R+L HA + + + G + IP++EDVS +++
Sbjct: 22 YTPVDQAVWRYVLRQLKAFLSKHA----HECYVEGLNKTGIDIERIPRIEDVSKKIQEF- 76
Query: 250 GFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ PV+G + F+ + V +R LYTP PD+ HE GHAP+ P
Sbjct: 77 GWRALPVSGFIPPAAFMELQSLGVLPIASDMRTLDHLLYTPAPDIVHEAAGHAPILIHPE 136
Query: 430 FAQFSQE 450
F+ + ++
Sbjct: 137 FSDYLRQ 143
>UniRef50_A3U7E2 Cluster: Phenylalanine 4-monooxygenase; n=13;
Bacteroidetes|Rep: Phenylalanine 4-monooxygenase -
Croceibacter atlanticus HTCC2559
Length = 586
Score = 57.6 bits (133), Expect = 2e-07
Identities = 38/136 (27%), Positives = 60/136 (44%)
Frame = +1
Query: 49 QPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVS 228
+P + DYT W V RK + K + + ++ G + IP + ++
Sbjct: 23 KPQNYDDYTAINQAVWRYVMRKNVE----YLGKVAHESYLSGLKKTGISINEIPSMYGMN 78
Query: 229 NFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHA 408
LKD G+ V G + F+ A++V IR YTP PD+ HE GHA
Sbjct: 79 RILKDI-GWAAVAVDGFIPPNAFMEFQAYKVLVIASDIRQLENIEYTPAPDIIHEGAGHA 137
Query: 409 PLFADPAFAQFSQEIG 456
P+ A P +A++ + G
Sbjct: 138 PIIASPDYAEYLRRFG 153
>UniRef50_A4A633 Cluster: Putative uncharacterized protein; n=1;
Congregibacter litoralis KT71|Rep: Putative
uncharacterized protein - Congregibacter litoralis KT71
Length = 596
Score = 52.4 bits (120), Expect = 8e-06
Identities = 38/139 (27%), Positives = 58/139 (41%)
Frame = +1
Query: 58 PHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFL 237
P YT + W + LT A + V+ + G D+IP +++++ L
Sbjct: 28 PDAQYTPRDHAVWRFLMTALTRGLAQTA----HPVYLEGLSRTGIALDHIPSIDEMNACL 83
Query: 238 KDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLF 417
G+ V G + F+ A +V +R LYTP PD+ HE GHAP
Sbjct: 84 AKL-GWRAVVVDGFIPPAIFMEFQALKVLVIALDMRSVEHLLYTPAPDILHESAGHAPFL 142
Query: 418 ADPAFAQFSQEIGLASLGA 474
D +A+F Q G + A
Sbjct: 143 VDVDYAEFLQRFGEVGMQA 161
>UniRef50_Q81LM9 Cluster: Phenylalanine-4-hydroxylase, putative;
n=10; Bacillus cereus group|Rep:
Phenylalanine-4-hydroxylase, putative - Bacillus
anthracis
Length = 584
Score = 49.6 bits (113), Expect = 5e-05
Identities = 26/94 (27%), Positives = 46/94 (48%)
Frame = +1
Query: 175 IENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHS 354
+++ G + IP++E+++ L +G+ + GL+ F + IR
Sbjct: 54 LQSSGINIEAIPKVEEMNECLAS-SGWGAVTIDGLIPGVAFFDFQGHGLLPIATDIRKVE 112
Query: 355 RPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIG 456
YTP PD+ HE GHAP+ DP +A++ + G
Sbjct: 113 NIEYTPAPDIVHEAAGHAPILLDPTYAKYVKRFG 146
>UniRef50_Q41AV6 Cluster: Aromatic amino acid hydroxylase; n=1;
Exiguobacterium sibiricum 255-15|Rep: Aromatic amino
acid hydroxylase - Exiguobacterium sibiricum 255-15
Length = 548
Score = 48.4 bits (110), Expect = 1e-04
Identities = 40/139 (28%), Positives = 57/139 (41%), Gaps = 1/139 (0%)
Frame = +1
Query: 43 HGQPLPHVDYTKEEIYTWGEVFR-KLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLE 219
H P + DYT + W V R L L T H L + G + IP +
Sbjct: 13 HVAPQHYDDYTPTDHAVWRYVMRLNLKTLQDT----AHPAYLEGLAAS-GISPERIPDVR 67
Query: 220 DVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELL 399
+++ L G+ V GL+ F + IR LYTP PD+ HE
Sbjct: 68 EMTANLSR-GGWGTVAVDGLIPGVAFFDFQGHGLLPIATDIRKVDNILYTPAPDILHEAA 126
Query: 400 GHAPLFADPAFAQFSQEIG 456
GHAP+ +P +A+F + G
Sbjct: 127 GHAPILMNPTYAEFVRRFG 145
>UniRef50_Q9Z6L3 Cluster: Probable aromatic amino acid hydroxylase;
n=2; Chlamydophila pneumoniae|Rep: Probable aromatic
amino acid hydroxylase - Chlamydia pneumoniae
(Chlamydophila pneumoniae)
Length = 362
Score = 47.6 bits (108), Expect = 2e-04
Identities = 24/78 (30%), Positives = 41/78 (52%)
Frame = +1
Query: 223 VSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLG 402
V F + T F+ PV+G ++ +L+ L R F +R + ++ PD+ H+LLG
Sbjct: 145 VIKFFELETHFSYYPVSGFVAPHQYLSLLQDRYFPIASVMRTLDKDNFSLTPDLIHDLLG 204
Query: 403 HAPLFADPAFAQFSQEIG 456
H P P+F++F +G
Sbjct: 205 HVPWLLHPSFSEFFINMG 222
>UniRef50_A6E752 Cluster: Phenylalanine-4-hydroxylase; n=1;
Pedobacter sp. BAL39|Rep: Phenylalanine-4-hydroxylase -
Pedobacter sp. BAL39
Length = 594
Score = 47.2 bits (107), Expect = 3e-04
Identities = 30/100 (30%), Positives = 47/100 (47%)
Frame = +1
Query: 175 IENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHS 354
++ G + IP L+ +++ L G+ V G + F+ A+ V IR +
Sbjct: 62 LQRAGLSIEYIPDLQTMNDNLGKI-GWGAVTVDGFIPPAAFMEYQAYHVLVIAADIRQIN 120
Query: 355 RPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGA 474
YTP PD+ HE GHAP+ AD + + G S+GA
Sbjct: 121 HIQYTPAPDIIHESAGHAPIIADADYNSYLSYFG--SIGA 158
>UniRef50_A6CNR8 Cluster: Phenylalanine 4-monooxygenase; n=1;
Bacillus sp. SG-1|Rep: Phenylalanine 4-monooxygenase -
Bacillus sp. SG-1
Length = 642
Score = 47.2 bits (107), Expect = 3e-04
Identities = 28/94 (29%), Positives = 46/94 (48%)
Frame = +1
Query: 175 IENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHS 354
++ G + IP++ +++ L G+ V GL+ F A + IR S
Sbjct: 119 LKGSGIAIEKIPRVSEMNEALGRI-GWGAVIVDGLIPGTAFFDLQAHGLLPIATDIRKVS 177
Query: 355 RPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIG 456
YTP PD+ HE GHAP+ D +++F ++IG
Sbjct: 178 NIEYTPAPDILHEAAGHAPILFDSTYSEFVKKIG 211
>UniRef50_A3UHY3 Cluster: Phenylalanine-4-hydroxylase; n=1;
Oceanicaulis alexandrii HTCC2633|Rep:
Phenylalanine-4-hydroxylase - Oceanicaulis alexandrii
HTCC2633
Length = 370
Score = 47.2 bits (107), Expect = 3e-04
Identities = 46/177 (25%), Positives = 73/177 (41%), Gaps = 26/177 (14%)
Frame = +1
Query: 67 DYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDC 246
DYT E W +F + P ACK+ F L +D IP +D++ LK
Sbjct: 64 DYTPAEHARWRLLFENQRKMLPGRACKDFMEGFEQLEH---LFKDGIPSFDDINAILKPA 120
Query: 247 TGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIR------------HHSRP----LYTP-E 375
TG+T+ PV L+ F L R F + +IR + R YT E
Sbjct: 121 TGWTVVPVPELIPDNIFFWHLENRRFPAGVFIRGGNPKTKKVKEANEGRAPEFVEYTAVE 180
Query: 376 PDVCH--------ELLGHAPLFADPAFAQFSQEIGLASLGAPD-DYIEKLATCFWFT 519
D+ + ++ GH P+ +P FA + Q G A + + ++ + +W+T
Sbjct: 181 DDLFYLQEPDTFHDIFGHVPMLMNPFFADYIQAYGAGGRRAIEYNRLKNFGSVYWYT 237
>UniRef50_Q255G4 Cluster: Aromatic amino acid hyroxylase
biopterin-dependent; n=3; Chlamydophila|Rep: Aromatic
amino acid hyroxylase biopterin-dependent -
Chlamydophila felis (strain Fe/C-56)
Length = 279
Score = 45.2 bits (102), Expect = 0.001
Identities = 22/80 (27%), Positives = 38/80 (47%)
Frame = +1
Query: 217 EDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHEL 396
+ +++ + +GFTL P G LS ++L L+ + F +R ++ PD+ H+L
Sbjct: 53 DHINSVISSQSGFTLSPTQGYLSPHNYLFELSQKRFPIATNVRSLEEDGFSTLPDLIHDL 112
Query: 397 LGHAPLFADPAFAQFSQEIG 456
H P P F F +G
Sbjct: 113 FCHIPWLLHPEFVNFFSTMG 132
>UniRef50_Q54SH1 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 1346
Score = 35.5 bits (78), Expect = 0.93
Identities = 38/110 (34%), Positives = 49/110 (44%), Gaps = 4/110 (3%)
Frame = +2
Query: 149 NTITYSRYLLRTVATEKTTSLSWKMSLTS*K-IAPDLHL--DRLPDYYRHVISSPA*PSE 319
+T T SR T T TT S + S + P L +RL + +S + P+
Sbjct: 285 STTTTSRLGSTTTTTSSTTVTSSPSRVASTSSLTPQKSLTPNRLSGTFPRTTTSSSTPTS 344
Query: 320 CSTARSILGTTPGRFILPNRTSAT-NC*DTHRCSRTLRSLSSPKRSASPL 466
S RS TT PNR S+T N + S T S SSP RSA+PL
Sbjct: 345 -SPLRSTSSTTTTSSSTPNRLSSTINKVVSSSPSSTSSSSSSPTRSATPL 393
>UniRef50_Q24990 Cluster: Vsp protein; n=1; Giardia
intestinalis|Rep: Vsp protein - Giardia lamblia (Giardia
intestinalis)
Length = 370
Score = 34.3 bits (75), Expect = 2.2
Identities = 14/31 (45%), Positives = 18/31 (58%)
Frame = -3
Query: 202 CLLCSHSSQ*VTGIRDCVPCKHVSGTGGSVS 110
C+ C S +TG+ DCV C SG GSV+
Sbjct: 288 CVKCDASDGQITGVTDCVSCAPPSGDSGSVT 318
>UniRef50_Q2W6R1 Cluster: ATP-sensitive inward rectifier potassium
channel 10; n=3; Magnetospirillum|Rep: ATP-sensitive
inward rectifier potassium channel 10 - Magnetospirillum
magneticum (strain AMB-1 / ATCC 700264)
Length = 320
Score = 33.9 bits (74), Expect = 2.8
Identities = 15/42 (35%), Positives = 24/42 (57%)
Frame = +1
Query: 304 GLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPA 429
G+ FR FH Q R HS P+++ + H + H+PL+ + A
Sbjct: 214 GMLFRRFHDLQLTRSHS-PIFSLSWTIMHPIDHHSPLYGETA 254
>UniRef50_A1RK23 Cluster: CRISPR-associated helicase Cas3 family;
n=9; Gammaproteobacteria|Rep: CRISPR-associated helicase
Cas3 family - Shewanella sp. (strain W3-18-1)
Length = 1137
Score = 33.9 bits (74), Expect = 2.8
Identities = 18/59 (30%), Positives = 29/59 (49%)
Frame = +1
Query: 340 IRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWF 516
+ HH PL P+ D+C + + D A+ S+E G + DY ++L +CF F
Sbjct: 215 VSHHRLPL--PDKDLCTDYKTESAASLDIMLARISKEWGYQNRYDEQDYEKRLKSCFRF 271
>UniRef50_A0YQI6 Cluster: Putative uncharacterized protein; n=1;
Lyngbya sp. PCC 8106|Rep: Putative uncharacterized
protein - Lyngbya sp. PCC 8106
Length = 431
Score = 33.9 bits (74), Expect = 2.8
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Frame = +1
Query: 106 FRKLTHLYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTL--RPVAGL 279
FRK HL P AC +HN + LI++C + C F L P+ L
Sbjct: 122 FRKFWHLIPATACPKHNSI---LIDSCPQCHQKLTWPRKSILHCSSCQ-FNLADSPIQHL 177
Query: 280 LSSRDFLAGLAFRVFH 327
L+ LA+R++H
Sbjct: 178 DQDEVALSSLAYRIYH 193
>UniRef50_Q4Z302 Cluster: Putative uncharacterized protein; n=2;
Plasmodium (Vinckeia)|Rep: Putative uncharacterized
protein - Plasmodium berghei
Length = 278
Score = 32.7 bits (71), Expect = 6.6
Identities = 13/28 (46%), Positives = 18/28 (64%)
Frame = +2
Query: 413 CSRTLRSLSSPKRSASPLWEHPMITLRN 496
CS+ +L SPK P +E P++TLRN
Sbjct: 180 CSKKANALPSPKGEEQPAFECPLVTLRN 207
>UniRef50_Q5EE48 Cluster: Proprotein convertase 6B; n=22;
Coelomata|Rep: Proprotein convertase 6B - Xenopus laevis
(African clawed frog)
Length = 1849
Score = 32.3 bits (70), Expect = 8.7
Identities = 13/38 (34%), Positives = 17/38 (44%)
Frame = -3
Query: 250 RCNLLRS*RHLPTEGCCLLCSHSSQ*VTGIRDCVPCKH 137
RC S R++ G C CSH + + DC C H
Sbjct: 1298 RCMSACSDRYMAVNGVCKHCSHGCKTCLSLNDCTECMH 1335
>UniRef50_Q5R3F8 Cluster: Leucine-rich repeat and fibronectin
type-III domain-containing protein 6 precursor; n=15;
Tetrapoda|Rep: Leucine-rich repeat and fibronectin
type-III domain-containing protein 6 precursor - Homo
sapiens (Human)
Length = 820
Score = 32.3 bits (70), Expect = 8.7
Identities = 27/96 (28%), Positives = 36/96 (37%), Gaps = 3/96 (3%)
Frame = +1
Query: 130 PTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGL 309
P + C EH H FP L Y E+ L +FLK T LS R + +G
Sbjct: 701 PAYHCSEHRHSFPAL-----YYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGY 755
Query: 310 AFRVFH---STQYIRHHSRPLYTPEPDVCHELLGHA 408
+ + ST I RP + + GHA
Sbjct: 756 SSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHA 791
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 629,245,839
Number of Sequences: 1657284
Number of extensions: 13191850
Number of successful extensions: 32311
Number of sequences better than 10.0: 62
Number of HSP's better than 10.0 without gapping: 31372
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 32294
length of database: 575,637,011
effective HSP length: 96
effective length of database: 416,537,747
effective search space used: 40820699206
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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