Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0003_F23
(585 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 302 5e-82
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 302 5e-82
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 301 1e-81
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 299 3e-81
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 284 2e-76
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 284 2e-76
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 284 2e-76
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 284 2e-76
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 284 2e-76
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 277 2e-74
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 256 4e-68
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 254 2e-67
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 254 2e-67
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 254 2e-67
AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase ... 109 9e-24
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 101 1e-21
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 81 2e-15
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 81 2e-15
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 79 9e-15
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 46 1e-04
S75697-1|AAD14181.1| 26|Homo sapiens PAH protein. 46 1e-04
S75699-1|AAD14182.1| 26|Homo sapiens PAH protein. 40 0.005
AY563525-1|AAS66667.1| 18|Homo sapiens phenylalanine hydroxyla... 36 0.14
Z94160-2|CAI22122.1| 820|Homo sapiens protein ( Human DNA seque... 32 1.3
AB067491-1|BAB67797.1| 821|Homo sapiens KIAA1904 protein protein. 32 1.3
AY722625-1|AAU11304.1| 17|Homo sapiens phenylalanine hydroxyla... 32 1.7
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 302 bits (742), Expect = 5e-82
Identities = 133/173 (76%), Positives = 150/173 (86%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARRK FADIAYNY+HGQP+P V+Y +EE TWG VF+ L LY THAC E+NH+FPLL +
Sbjct: 156 ARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEK 215
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRDFL GLAFRVFH TQYIRH S+P
Sbjct: 216 YCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKP 275
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGAPD+YIEKLAT +WFT
Sbjct: 276 MYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFT 328
Score = 31.5 bits (68), Expect = 2.3
Identities = 14/32 (43%), Positives = 20/32 (62%), Gaps = 2/32 (6%)
Frame = +3
Query: 495 ISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
I + +YW ++FG+C +KAYGA LLS
Sbjct: 318 IEKLATIYWFTVEFGLCKQGDSIKAYGAGLLS 349
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 302 bits (742), Expect = 5e-82
Identities = 133/173 (76%), Positives = 150/173 (86%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARRK FADIAYNY+HGQP+P V+Y +EE TWG VF+ L LY THAC E+NH+FPLL +
Sbjct: 156 ARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEK 215
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRDFL GLAFRVFH TQYIRH S+P
Sbjct: 216 YCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKP 275
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGAPD+YIEKLAT +WFT
Sbjct: 276 MYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFT 328
Score = 31.5 bits (68), Expect = 2.3
Identities = 14/32 (43%), Positives = 20/32 (62%), Gaps = 2/32 (6%)
Frame = +3
Query: 495 ISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
I + +YW ++FG+C +KAYGA LLS
Sbjct: 318 IEKLATIYWFTVEFGLCKQGDSIKAYGAGLLS 349
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 301 bits (739), Expect = 1e-81
Identities = 132/173 (76%), Positives = 150/173 (86%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARRK FADIAYNY+HGQP+P V+Y +EE TWG VF+ L LY THAC E+NH+FPLL +
Sbjct: 156 ARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEK 215
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRDFL GLAFRVFH TQYIRH S+P
Sbjct: 216 YCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKP 275
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+YTP+PD+CHELLGH PLF+D +FAQFSQEIGLASLGAPD+YIEKLAT +WFT
Sbjct: 276 MYTPQPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFT 328
Score = 31.5 bits (68), Expect = 2.3
Identities = 14/32 (43%), Positives = 20/32 (62%), Gaps = 2/32 (6%)
Frame = +3
Query: 495 ISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
I + +YW ++FG+C +KAYGA LLS
Sbjct: 318 IEKLATIYWFTVEFGLCKQGDSIKAYGAGLLS 349
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 299 bits (735), Expect = 3e-81
Identities = 132/173 (76%), Positives = 149/173 (86%)
Frame = +1
Query: 1 ARRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIE 180
ARRK FADIAYNY+HGQP+P V+Y +E TWG VF+ L LY THAC E+NH+FPLL +
Sbjct: 156 ARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEK 215
Query: 181 NCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRP 360
CG+ EDNIPQLEDVS FL+ CTGF LRPVAGLLSSRDFL GLAFRVFH TQYIRH S+P
Sbjct: 216 YCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKP 275
Query: 361 LYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
+YTPEPD+CHELLGH PLF+D +FAQFSQEIGLASLGAPD+YIEKLAT +WFT
Sbjct: 276 MYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFT 328
Score = 31.5 bits (68), Expect = 2.3
Identities = 14/32 (43%), Positives = 20/32 (62%), Gaps = 2/32 (6%)
Frame = +3
Query: 495 ISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
I + +YW ++FG+C +KAYGA LLS
Sbjct: 318 IEKLATIYWFTVEFGLCKQGDSIKAYGAGLLS 349
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 284 bits (696), Expect = 2e-76
Identities = 124/172 (72%), Positives = 147/172 (85%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYFAD+A NYKHG P+P V++T+EEI TWG VF++L LYPTHAC+E+ PLL +
Sbjct: 144 RRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKY 203
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDNIPQLEDVSNFLK+ TGF++RPVAG LS RDFL+GLAFRVFH TQY+RH S P
Sbjct: 204 CGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPF 263
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLGA ++ ++KLATC++FT
Sbjct: 264 YTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFT 315
Score = 29.5 bits (63), Expect = 9.1
Identities = 10/23 (43%), Positives = 18/23 (78%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C +G+L+ +GA LLS
Sbjct: 314 FTVEFGLCKQDGQLRVFGAGLLS 336
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 284 bits (696), Expect = 2e-76
Identities = 126/172 (73%), Positives = 146/172 (84%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYF D+A YK+GQP+P V+YT+EE TWG VFR+L+ LYPTHAC+E+ FPLL +
Sbjct: 190 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 249
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS RDFLAGLA+RVFH TQYIRH S PL
Sbjct: 250 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 309
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL ADP FAQFSQEIGLASLGA D+ ++KLATC++FT
Sbjct: 310 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFT 361
Score = 34.3 bits (75), Expect = 0.32
Identities = 13/23 (56%), Positives = 19/23 (82%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C EG+L+AYGA LLS
Sbjct: 360 FTIEFGLCKQEGQLRAYGAGLLS 382
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 284 bits (696), Expect = 2e-76
Identities = 126/172 (73%), Positives = 146/172 (84%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYF D+A YK+GQP+P V+YT+EE TWG VFR+L+ LYPTHAC+E+ FPLL +
Sbjct: 196 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 255
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS RDFLAGLA+RVFH TQYIRH S PL
Sbjct: 256 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 315
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL ADP FAQFSQEIGLASLGA D+ ++KLATC++FT
Sbjct: 316 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFT 367
Score = 34.3 bits (75), Expect = 0.32
Identities = 13/23 (56%), Positives = 19/23 (82%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C EG+L+AYGA LLS
Sbjct: 366 FTIEFGLCKQEGQLRAYGAGLLS 388
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 284 bits (696), Expect = 2e-76
Identities = 124/172 (72%), Positives = 147/172 (85%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYFAD+A NYKHG P+P V++T+EEI TWG VF++L LYPTHAC+E+ PLL +
Sbjct: 144 RRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKY 203
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDNIPQLEDVSNFLK+ TGF++RPVAG LS RDFL+GLAFRVFH TQY+RH S P
Sbjct: 204 CGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPF 263
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLGA ++ ++KLATC++FT
Sbjct: 264 YTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFT 315
Score = 29.5 bits (63), Expect = 9.1
Identities = 10/23 (43%), Positives = 18/23 (78%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C +G+L+ +GA LLS
Sbjct: 314 FTVEFGLCKQDGQLRVFGAGLLS 336
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 284 bits (696), Expect = 2e-76
Identities = 126/172 (73%), Positives = 146/172 (84%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYF D+A YK+GQP+P V+YT+EE TWG VFR+L+ LYPTHAC+E+ FPLL +
Sbjct: 190 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 249
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGYREDN+PQLEDVS FLK+ +GFT+RPVAG LS RDFLAGLA+RVFH TQYIRH S PL
Sbjct: 250 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 309
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL ADP FAQFSQEIGLASLGA D+ ++KLATC++FT
Sbjct: 310 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFT 361
Score = 34.3 bits (75), Expect = 0.32
Identities = 13/23 (56%), Positives = 19/23 (82%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C EG+L+AYGA LLS
Sbjct: 360 FTIEFGLCKQEGQLRAYGAGLLS 382
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 277 bits (680), Expect = 2e-74
Identities = 121/172 (70%), Positives = 146/172 (84%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYFAD A +YK+G P+P V++T+EEI TWG VFR+L LYPTHAC+E+ PLL +
Sbjct: 144 RRKYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSKY 203
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
CGY+EDNIPQLED+SNFLK+ TGF++RPVAG LS RDFL+GLAFRVFH TQY+RH S P
Sbjct: 204 CGYQEDNIPQLEDISNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPF 263
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLGA ++ ++KLATC++FT
Sbjct: 264 YTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFT 315
Score = 29.5 bits (63), Expect = 9.1
Identities = 10/23 (43%), Positives = 18/23 (78%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C +G+L+ +GA LLS
Sbjct: 314 FTVEFGLCKQDGQLRVFGAGLLS 336
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 256 bits (627), Expect = 4e-68
Identities = 118/172 (68%), Positives = 134/172 (77%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ Y+HG P+P V+YT EEI TW EV+ L LY THAC EH F LL
Sbjct: 202 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERF 261
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 262 SGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 321
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA D+ IEKL+T +WFT
Sbjct: 322 HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFT 373
Score = 36.3 bits (80), Expect = 0.080
Identities = 16/33 (48%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + +YW ++FG+C G++KAYGA LLS
Sbjct: 362 EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLS 394
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 254 bits (622), Expect = 2e-67
Identities = 118/172 (68%), Positives = 133/172 (77%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ Y+HG P+P V+YT EEI TW EV+ L LY THAC EH F LL
Sbjct: 229 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERF 288
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 289 SGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 348
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA D+ IEKL+T WFT
Sbjct: 349 HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFT 400
Score = 32.7 bits (71), Expect = 0.98
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + + W ++FG+C G++KAYGA LLS
Sbjct: 389 EIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLS 421
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 254 bits (622), Expect = 2e-67
Identities = 118/172 (68%), Positives = 133/172 (77%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ Y+HG P+P V+YT EEI TW EV+ L LY THAC EH F LL
Sbjct: 202 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERF 261
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 262 SGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 321
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA D+ IEKL+T WFT
Sbjct: 322 HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFT 373
Score = 32.7 bits (71), Expect = 0.98
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + + W ++FG+C G++KAYGA LLS
Sbjct: 362 EIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLS 394
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 254 bits (622), Expect = 2e-67
Identities = 118/172 (68%), Positives = 133/172 (77%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRK A+IA+ Y+HG P+P V+YT EEI TW EV+ L LY THAC EH F LL
Sbjct: 233 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERF 292
Query: 184 CGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPL 363
GYREDNIPQLEDVS FLK+ TGF LRPVAGLLS+RDFLA LAFRVF TQYIRH S P+
Sbjct: 293 SGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPM 352
Query: 364 YTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFT 519
++PEPD CHELLGH P+ AD FAQFSQ+IGLASLGA D+ IEKL+T WFT
Sbjct: 353 HSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFT 404
Score = 32.7 bits (71), Expect = 0.98
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + + W ++FG+C G++KAYGA LLS
Sbjct: 393 EIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLS 425
>AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase
protein.
Length = 163
Score = 109 bits (261), Expect = 9e-24
Identities = 45/62 (72%), Positives = 54/62 (87%)
Frame = +1
Query: 334 QYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFW 513
QY+RH S P YTPEPD CHELLGH PL A+P+FAQFSQEIGLASLGA ++ ++KLATC++
Sbjct: 1 QYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYF 60
Query: 514 FT 519
FT
Sbjct: 61 FT 62
Score = 29.5 bits (63), Expect = 9.1
Identities = 10/23 (43%), Positives = 18/23 (78%)
Frame = +3
Query: 516 YWLKFGMCSAEGKLKAYGAWLLS 584
+ ++FG+C +G+L+ +GA LLS
Sbjct: 61 FTVEFGLCKQDGQLRVFGAGLLS 83
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 101 bits (243), Expect = 1e-21
Identities = 42/65 (64%), Positives = 52/65 (80%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHLYPTHACKEHNHVFPLLIEN 183
RRKYFAD+A NYKHG P+P V++T+EEI TWG VF++L LYPTHAC+E+ PLL +
Sbjct: 142 RRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKY 201
Query: 184 CGYRE 198
CGYRE
Sbjct: 202 CGYRE 206
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 81.4 bits (192), Expect = 2e-15
Identities = 40/77 (51%), Positives = 48/77 (62%)
Frame = +1
Query: 289 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 468
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 207 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 266
Query: 469 GAPDDYIEKLATCFWFT 519
GA D+ IEKL+T +WFT
Sbjct: 267 GASDEEIEKLSTLYWFT 283
Score = 51.2 bits (117), Expect = 3e-06
Identities = 21/41 (51%), Positives = 27/41 (65%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHL 126
RRK A+IA+ Y+HG P+P V+YT EEI TW L H+
Sbjct: 206 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHV 246
Score = 36.3 bits (80), Expect = 0.080
Identities = 16/33 (48%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + +YW ++FG+C G++KAYGA LLS
Sbjct: 272 EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLS 304
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 81.4 bits (192), Expect = 2e-15
Identities = 40/77 (51%), Positives = 48/77 (62%)
Frame = +1
Query: 289 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 468
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 203 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 262
Query: 469 GAPDDYIEKLATCFWFT 519
GA D+ IEKL+T +WFT
Sbjct: 263 GASDEEIEKLSTLYWFT 279
Score = 51.2 bits (117), Expect = 3e-06
Identities = 21/41 (51%), Positives = 27/41 (65%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHL 126
RRK A+IA+ Y+HG P+P V+YT EEI TW L H+
Sbjct: 202 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHV 242
Score = 36.3 bits (80), Expect = 0.080
Identities = 16/33 (48%), Positives = 23/33 (69%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + +YW ++FG+C G++KAYGA LLS
Sbjct: 268 EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLS 300
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 79.4 bits (187), Expect = 9e-15
Identities = 40/77 (51%), Positives = 47/77 (61%)
Frame = +1
Query: 289 RDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASL 468
R +A +AF+ H R D CHELLGH P+ AD FAQFSQ+IGLASL
Sbjct: 16 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 75
Query: 469 GAPDDYIEKLATCFWFT 519
GA D+ IEKL+T WFT
Sbjct: 76 GASDEEIEKLSTLSWFT 92
Score = 51.2 bits (117), Expect = 3e-06
Identities = 21/41 (51%), Positives = 27/41 (65%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYTWGEVFRKLTHL 126
RRK A+IA+ Y+HG P+P V+YT EEI TW L H+
Sbjct: 15 RRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHV 55
Score = 32.7 bits (71), Expect = 0.98
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +3
Query: 492 EISHVFLVYW--LKFGMCSAEGKLKAYGAWLLS 584
EI + + W ++FG+C G++KAYGA LLS
Sbjct: 81 EIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLS 113
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 46.0 bits (104), Expect = 1e-04
Identities = 18/30 (60%), Positives = 23/30 (76%)
Frame = +1
Query: 4 RRKYFADIAYNYKHGQPLPHVDYTKEEIYT 93
RRK A+IA+ Y+HG P+P V+YT EEI T
Sbjct: 15 RRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>S75697-1|AAD14181.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 45.6 bits (103), Expect = 1e-04
Identities = 20/25 (80%), Positives = 21/25 (84%)
Frame = +1
Query: 232 FLKDCTGFTLRPVAGLLSSRDFLAG 306
F+ CTGF LRPVAGLLSSRDFL G
Sbjct: 2 FIPACTGFCLRPVAGLLSSRDFLGG 26
>S75699-1|AAD14182.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 40.3 bits (90), Expect = 0.005
Identities = 18/25 (72%), Positives = 20/25 (80%)
Frame = +1
Query: 232 FLKDCTGFTLRPVAGLLSSRDFLAG 306
F+ CTGF L+PVA LLSSRDFL G
Sbjct: 2 FIPACTGFRLQPVAVLLSSRDFLGG 26
>AY563525-1|AAS66667.1| 18|Homo sapiens phenylalanine hydroxylase
protein.
Length = 18
Score = 35.5 bits (78), Expect = 0.14
Identities = 13/18 (72%), Positives = 15/18 (83%)
Frame = +1
Query: 325 HSTQYIRHHSRPLYTPEP 378
H TQYIRH S+P+YTP P
Sbjct: 1 HCTQYIRHGSKPMYTPGP 18
>Z94160-2|CAI22122.1| 820|Homo sapiens protein ( Human DNA sequence
from clone RP1-63G5 on chromosome 22q12.3-13.1. ).
Length = 820
Score = 32.3 bits (70), Expect = 1.3
Identities = 27/96 (28%), Positives = 36/96 (37%), Gaps = 3/96 (3%)
Frame = +1
Query: 130 PTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGL 309
P + C EH H FP L Y E+ L +FLK T LS R + +G
Sbjct: 701 PAYHCSEHRHSFPAL-----YYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGY 755
Query: 310 AFRVFH---STQYIRHHSRPLYTPEPDVCHELLGHA 408
+ + ST I RP + + GHA
Sbjct: 756 SSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHA 791
>AB067491-1|BAB67797.1| 821|Homo sapiens KIAA1904 protein protein.
Length = 821
Score = 32.3 bits (70), Expect = 1.3
Identities = 27/96 (28%), Positives = 36/96 (37%), Gaps = 3/96 (3%)
Frame = +1
Query: 130 PTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGL 309
P + C EH H FP L Y E+ L +FLK T LS R + +G
Sbjct: 702 PAYHCSEHRHSFPAL-----YYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGY 756
Query: 310 AFRVFH---STQYIRHHSRPLYTPEPDVCHELLGHA 408
+ + ST I RP + + GHA
Sbjct: 757 SSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHA 792
>AY722625-1|AAU11304.1| 17|Homo sapiens phenylalanine hydroxylase
protein.
Length = 17
Score = 31.9 bits (69), Expect = 1.7
Identities = 13/16 (81%), Positives = 14/16 (87%)
Frame = +1
Query: 190 YREDNIPQLEDVSNFL 237
+ EDNIPQLEDVS FL
Sbjct: 1 FHEDNIPQLEDVSQFL 16
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 93,164,107
Number of Sequences: 237096
Number of extensions: 2019242
Number of successful extensions: 4241
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 4052
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4241
length of database: 76,859,062
effective HSP length: 86
effective length of database: 56,468,806
effective search space used: 6098631048
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -