Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0003_E24
(537 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q17DR1 Cluster: Cystathionine beta-lyase; n=6; Coelomat... 246 3e-64
UniRef50_Q8VCN5 Cluster: Cystathionine gamma-lyase; n=39; Eukary... 235 4e-61
UniRef50_UPI000155C3C4 Cluster: PREDICTED: similar to cystathion... 231 6e-60
UniRef50_P32929 Cluster: Cystathionine gamma-lyase; n=38; cellul... 225 5e-58
UniRef50_Q129P6 Cluster: Cystathionine gamma-synthase; n=11; cel... 201 9e-51
UniRef50_Q23CV0 Cluster: Cystathionine beta-lyase; n=3; Oligohym... 200 1e-50
UniRef50_Q838Z2 Cluster: Cystathionine beta-lyase; n=8; Bacteria... 193 2e-48
UniRef50_P56069 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 189 3e-47
UniRef50_Q8KEI8 Cluster: Trans-sulfuration enzyme family protein... 182 3e-45
UniRef50_Q5UZS6 Cluster: Cystathionine gamma-synthase; n=3; cell... 182 3e-45
UniRef50_Q1INQ0 Cluster: Cystathionine gamma-synthase; n=2; Bact... 179 4e-44
UniRef50_P46807 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 179 4e-44
UniRef50_Q4A0K3 Cluster: Cystathionine gamma-synthase; n=4; Bact... 177 1e-43
UniRef50_A6QZA3 Cluster: Cystathionine gamma-lyase; n=1; Ajellom... 175 5e-43
UniRef50_Q74EL7 Cluster: Cystathionine beta-lyase; n=5; Bacteria... 171 7e-42
UniRef50_A5E0C2 Cluster: Cystathionine gamma-lyase; n=6; cellula... 171 7e-42
UniRef50_A7HF96 Cluster: Cystathionine gamma-synthase; n=7; Bact... 171 1e-41
UniRef50_Q9EWF9 Cluster: Cystathionine gamma-synthase; n=6; Bact... 169 3e-41
UniRef50_Q97M10 Cluster: Cystathionine gamma-synthase; n=15; Bac... 169 5e-41
UniRef50_Q6N7A1 Cluster: Cystathionine gamma-lyase; n=52; cellul... 163 2e-39
UniRef50_Q8XNZ9 Cluster: Cystathionine gamma-synthase; n=7; Bact... 163 2e-39
UniRef50_Q67R76 Cluster: Cystathionine gamma-lyase; n=13; Bacter... 162 4e-39
UniRef50_A1ZDN6 Cluster: Cystathionine beta-lyase; n=1; Microsci... 161 9e-39
UniRef50_Q5L1M8 Cluster: Cystathionine beta-lyase; n=42; Bacteri... 159 3e-38
UniRef50_Q8G805 Cluster: Cystathionine beta-lyase; n=2; Bifidoba... 158 7e-38
UniRef50_Q8R9M2 Cluster: Cystathionine beta-lyases/cystathionine... 158 9e-38
UniRef50_A1A0Q5 Cluster: Cystathionine beta-lyase; n=2; Bifidoba... 157 1e-37
UniRef50_Q8TMW7 Cluster: Methionine gamma-lyase; n=3; Methanosar... 157 2e-37
UniRef50_P53780 Cluster: Cystathionine beta-lyase, chloroplast p... 157 2e-37
UniRef50_Q2IEA5 Cluster: Cystathionine gamma-synthase; n=1; Anae... 156 3e-37
UniRef50_A5GJ98 Cluster: MetC/metB Cystathionine beta-lyase/cyst... 155 5e-37
UniRef50_P00935 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 155 5e-37
UniRef50_A0LLP6 Cluster: Cystathionine gamma-synthase; n=1; Synt... 154 1e-36
UniRef50_A3HJ37 Cluster: Cystathionine gamma-lyase; n=7; Gammapr... 153 2e-36
UniRef50_O15564 Cluster: Methionine gamma-lyase; n=2; Trichomona... 152 4e-36
UniRef50_P55217 Cluster: Cystathionine gamma-synthase, chloropla... 151 7e-36
UniRef50_Q3JCU1 Cluster: Cystathionine gamma-synthase; n=1; Nitr... 151 1e-35
UniRef50_A3JID5 Cluster: Cystathionine beta-lyase; n=3; Marinoba... 150 2e-35
UniRef50_Q7UQA0 Cluster: Cystathionine gamma-synthase; n=4; Bact... 149 4e-35
UniRef50_P13254 Cluster: Methionine gamma-lyase; n=33; cellular ... 149 5e-35
UniRef50_Q26GX1 Cluster: Cys/Met metabolism PLP-dependent enzyme... 148 7e-35
UniRef50_A3VS82 Cluster: Cystathionine gamma-synthase; n=1; Parv... 148 7e-35
UniRef50_Q8KNG3 Cluster: CalE6; n=2; Micromonosporaceae|Rep: Cal... 147 1e-34
UniRef50_Q5MQ31 Cluster: L-methionine-gamma-lyase; n=3; Micrococ... 147 1e-34
UniRef50_Q86D27 Cluster: Methionine gamma-lyase 2; n=3; Entamoeb... 147 1e-34
UniRef50_Q12L75 Cluster: Methionine gamma-lyase; n=1; Shewanella... 147 2e-34
UniRef50_UPI00015BB00D Cluster: cystathionine gamma-synthase; n=... 146 3e-34
UniRef50_Q1J8Q9 Cluster: Cystathionine beta-lyase; n=14; Bacilli... 146 4e-34
UniRef50_Q0ALD7 Cluster: Cystathionine gamma-synthase; n=2; Hyph... 145 5e-34
UniRef50_Q9YA71 Cluster: Cystathionine gamma-synthase; n=1; Aero... 144 9e-34
UniRef50_Q9KEQ0 Cluster: Methionine gamma lyase; n=13; Bacillace... 143 2e-33
UniRef50_A1ID11 Cluster: Cystathionine gamma-synthase; n=1; Cand... 143 3e-33
UniRef50_A2BL10 Cluster: Methionine gamma-lyase; n=1; Hypertherm... 141 1e-32
UniRef50_Q8R9N2 Cluster: Cystathionine beta-lyases/cystathionine... 140 2e-32
UniRef50_A6X770 Cluster: Cystathionine gamma-synthase; n=1; Ochr... 138 6e-32
UniRef50_A6LPZ9 Cluster: Cystathionine gamma-synthase; n=4; Bact... 138 1e-31
UniRef50_A5V1Q1 Cluster: Cystathionine gamma-synthase; n=2; Rose... 138 1e-31
UniRef50_Q98K64 Cluster: Methionine gamma-lyase; n=13; Bacteria|... 137 2e-31
UniRef50_A6GHC8 Cluster: Cystathionine gamma-synthase; n=1; Ples... 137 2e-31
UniRef50_A6YH84 Cluster: Cystathionine gamma-synthase; n=2; Lact... 136 2e-31
UniRef50_A1HQW4 Cluster: Cystathionine gamma-synthase; n=1; Ther... 136 4e-31
UniRef50_Q9K024 Cluster: Cystathionine gamma-synthase; n=4; Neis... 135 5e-31
UniRef50_Q1IQ68 Cluster: Cystathionine gamma-synthase; n=1; Acid... 134 9e-31
UniRef50_Q67QQ8 Cluster: Cystathionine gamma-lyase; n=1; Symbiob... 134 1e-30
UniRef50_Q5GSE3 Cluster: Cystathionine beta-lyase; n=5; Wolbachi... 134 1e-30
UniRef50_Q7X1G1 Cluster: Lfe147p1; n=2; Leptospirillum|Rep: Lfe1... 134 1e-30
UniRef50_Q1GVW8 Cluster: Cystathionine gamma-lyase; n=15; Bacter... 134 1e-30
UniRef50_A6W1L9 Cluster: Cystathionine gamma-synthase; n=10; Bac... 134 1e-30
UniRef50_Q97W69 Cluster: O-succinylhomoserine (Thiol)-lyase; n=5... 133 3e-30
UniRef50_Q5WAZ1 Cluster: Methionine gamma-lyase; n=1; Bacillus c... 132 5e-30
UniRef50_Q1IQ69 Cluster: Cystathionine beta-lyase; n=6; Bacteria... 131 9e-30
UniRef50_Q97CC7 Cluster: Cystathionine beta lyase / O-succinylho... 131 1e-29
UniRef50_A4EYE9 Cluster: Cystathionine beta-lyase/cystathionine ... 130 2e-29
UniRef50_Q62BJ4 Cluster: Trans-sulfuration enzyme family protein... 129 3e-29
UniRef50_Q7W586 Cluster: Cystathionine beta-lyase; n=3; Bordetel... 128 8e-29
UniRef50_Q0LLX7 Cluster: Cystathionine gamma-synthase; n=3; Bact... 128 1e-28
UniRef50_P24601 Cluster: Probable cystathionine gamma-synthase (... 128 1e-28
UniRef50_Q0APK0 Cluster: Cystathionine beta-lyase; n=1; Maricaul... 127 1e-28
UniRef50_Q5QU17 Cluster: Methionine gamma-lyase; n=29; cellular ... 127 2e-28
UniRef50_Q01X62 Cluster: Cystathionine gamma-synthase; n=1; Soli... 126 3e-28
UniRef50_Q38DH3 Cluster: Cystathione gamma lyase, putative; n=7;... 126 3e-28
UniRef50_Q96VU8 Cluster: Cystathionine beta-lyase; n=3; Pezizomy... 126 3e-28
UniRef50_A7H124 Cluster: Methionine gamma-lyase; n=2; Campylobac... 126 4e-28
UniRef50_A0NJV2 Cluster: O-succinylhomoserine thiol-lyase; n=2; ... 126 4e-28
UniRef50_Q97PS4 Cluster: Transulfuration enzyme family protein; ... 125 6e-28
UniRef50_Q1AT24 Cluster: Cystathionine gamma-synthase; n=2; Bact... 125 7e-28
UniRef50_P55218 Cluster: O-succinylhomoserine sulfhydrylase; n=9... 125 7e-28
UniRef50_O02215 Cluster: Putative uncharacterized protein; n=3; ... 124 1e-27
UniRef50_Q9KCE4 Cluster: Cystathionine gamma-synthase (O-succiny... 124 2e-27
UniRef50_A5G088 Cluster: Cystathionine gamma-synthase; n=1; Acid... 124 2e-27
UniRef50_A5CVL3 Cluster: O-succinylhomoserine sulfhydrylase; n=3... 124 2e-27
UniRef50_A1SSS1 Cluster: Cystathionine beta-lyase; n=10; Gammapr... 122 4e-27
UniRef50_Q7WM51 Cluster: Cystathionase beta-lyase; n=3; Proteoba... 122 5e-27
UniRef50_A4AND2 Cluster: Cystathionine gamma-lyase; n=2; cellula... 122 5e-27
UniRef50_Q2JBH0 Cluster: O-succinylhomoserine sulfhydrylase; n=1... 122 7e-27
UniRef50_Q4PK57 Cluster: Predicted cystathionine beta-lyase; n=1... 122 7e-27
UniRef50_Q1ELY9 Cluster: Cystathionine beta-lyases/cystathionine... 122 7e-27
UniRef50_Q2AGF7 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 121 9e-27
UniRef50_P44527 Cluster: Cystathionine beta-lyase; n=78; Gammapr... 121 9e-27
UniRef50_Q52811 Cluster: Putative cystathionine beta-lyase; n=35... 121 1e-26
UniRef50_P44502 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 120 2e-26
UniRef50_A7H1V2 Cluster: Cystathionine beta-lyase; n=15; Campylo... 120 2e-26
UniRef50_A0VE37 Cluster: Cystathionine beta-lyase; n=2; Comamona... 120 2e-26
UniRef50_A0JSU6 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 120 2e-26
UniRef50_A3UCF8 Cluster: Cystathionine beta-lyase; n=1; Oceanica... 120 3e-26
UniRef50_Q6AJ03 Cluster: Probable cystathionine beta-lyase; n=1;... 119 5e-26
UniRef50_A6UGP2 Cluster: Cystathionine gamma-synthase; n=1; Sino... 119 5e-26
UniRef50_Q07703 Cluster: Cystathionine beta-lyase; n=6; Burkhold... 118 6e-26
UniRef50_Q1GNK9 Cluster: Cystathionine beta-lyase; n=4; Sphingom... 117 1e-25
UniRef50_A6PIC3 Cluster: Cystathionine beta-lyase; n=1; Shewanel... 117 1e-25
UniRef50_Q9V088 Cluster: MetB cystathionine gamma-synthase (EC 4... 117 1e-25
UniRef50_Q67KY0 Cluster: O-acetylhomoserine sulfhydrylase; n=28;... 117 2e-25
UniRef50_Q1VZU8 Cluster: Cystathionine beta-lyase; n=12; Bactero... 117 2e-25
UniRef50_Q5NQQ3 Cluster: Cystathionine beta-lyase; n=41; Proteob... 116 3e-25
UniRef50_Q13Z52 Cluster: Cystathionine beta-lyase; n=2; Burkhold... 116 3e-25
UniRef50_Q0B7N7 Cluster: Cystathionine gamma-synthase; n=4; Beta... 116 3e-25
UniRef50_Q6L1U0 Cluster: Cystathionine beta-lyase; n=1; Picrophi... 116 3e-25
UniRef50_Q4QFT8 Cluster: Cystathionine beta-lyase-like protein; ... 116 3e-25
UniRef50_Q46V95 Cluster: Cystathionine beta-lyase, bacterial; n=... 115 8e-25
UniRef50_Q1QM61 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 115 8e-25
UniRef50_A3UCA9 Cluster: Cystathionine gamma-synthase; n=2; Hyph... 115 8e-25
UniRef50_Q7M844 Cluster: O-ACETYLHOMOSERINE (THIOL)-LYASE; n=1; ... 114 1e-24
UniRef50_Q8RI67 Cluster: Cystathionine beta-lyase; n=2; Bacteria... 113 2e-24
UniRef50_Q67VG6 Cluster: Putative O-succinylhomoserine (Thiol)-l... 113 3e-24
UniRef50_A3X9V5 Cluster: Cystathionine gamma-synthase; n=12; Rho... 112 6e-24
UniRef50_Q5FUW3 Cluster: Cystathionine beta-lyase; n=3; Acetobac... 111 7e-24
UniRef50_A6NZI8 Cluster: Putative uncharacterized protein; n=1; ... 111 7e-24
UniRef50_Q1IQD6 Cluster: Cystathionine gamma-synthase; n=2; Acid... 111 1e-23
UniRef50_A6W2A4 Cluster: Cystathionine beta-lyase; n=1; Marinomo... 111 1e-23
UniRef50_Q0C2A8 Cluster: Cystathionine beta-lyase; n=1; Hyphomon... 110 2e-23
UniRef50_A0LY60 Cluster: O-succinylhomoserine sulfhydrylase; n=1... 110 2e-23
UniRef50_Q89VE2 Cluster: O-succinylhomoserine sulfhydrylase; n=7... 110 2e-23
UniRef50_Q493X0 Cluster: Beta-cystathionase; n=2; Enterobacteria... 109 4e-23
UniRef50_P53101 Cluster: Cystathionine beta-lyase; n=5; Saccharo... 109 4e-23
UniRef50_Q6MN74 Cluster: Cys/Met metabolism lyase; n=1; Bdellovi... 109 5e-23
UniRef50_A4AA77 Cluster: Cystathionine beta-lyase; n=2; Bacteria... 109 5e-23
UniRef50_A3SR24 Cluster: Cystathionine gamma-synthase; n=3; Alph... 109 5e-23
UniRef50_A0H5P3 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 109 5e-23
UniRef50_Q11FS5 Cluster: Cystathionine beta-lyase; n=5; Alphapro... 108 7e-23
UniRef50_A7S3X8 Cluster: Predicted protein; n=1; Nematostella ve... 108 7e-23
UniRef50_Q62JZ5 Cluster: Cystathionine beta-lyase; n=37; Burkhol... 108 9e-23
UniRef50_Q5PBE9 Cluster: Cystathionine beta-lyase; n=1; Anaplasm... 108 9e-23
UniRef50_O94350 Cluster: Cystathionine beta-lyase; n=27; cellula... 108 9e-23
UniRef50_Q49UL2 Cluster: Cystathionine beta-lyase cystathionine ... 107 1e-22
UniRef50_O69592 Cluster: O-succinylhomoserine sulfhydrylase; n=1... 107 2e-22
UniRef50_A5WGJ5 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 107 2e-22
UniRef50_Q1GQF1 Cluster: Cystathionine beta-lyase; n=1; Sphingop... 107 2e-22
UniRef50_A6GRN0 Cluster: Cystathionine beta-lyase; n=1; Limnobac... 106 3e-22
UniRef50_Q5QWY7 Cluster: Cystathionine gamma-synthase; n=5; Prot... 106 4e-22
UniRef50_Q8FRS9 Cluster: O-acetylhomoserine sulfhydrylase; n=8; ... 105 5e-22
UniRef50_A0L907 Cluster: Cystathionine gamma-synthase; n=1; Magn... 105 5e-22
UniRef50_Q9X0Z7 Cluster: Cystathionine gamma-synthase; n=2; Ther... 105 6e-22
UniRef50_A6LZ85 Cluster: O-acetylhomoserine aminocarboxypropyltr... 105 9e-22
UniRef50_A2Y9X5 Cluster: Putative uncharacterized protein; n=1; ... 105 9e-22
UniRef50_A5CMC2 Cluster: O-acetylhomoserine (Thiol)-lyase; n=2; ... 104 1e-21
UniRef50_Q399B4 Cluster: Cystathionine beta-lyase; n=15; Proteob... 104 1e-21
UniRef50_A5WG79 Cluster: O-succinylhomoserine sulfhydrylase; n=6... 103 2e-21
UniRef50_Q9RSD8 Cluster: O-acetylhomoserine (Thiol)-lyase/O-acet... 103 3e-21
UniRef50_Q2S2T9 Cluster: Cystathionine beta-lyase MetC; n=1; Sal... 103 3e-21
UniRef50_A3VUE2 Cluster: Cystathionine beta-lyase; n=1; Parvular... 103 3e-21
UniRef50_UPI0000E47CE2 Cluster: PREDICTED: similar to cystathion... 103 3e-21
UniRef50_A5EU95 Cluster: Cystathionine beta-lyase; n=1; Bradyrhi... 103 3e-21
UniRef50_Q8EM13 Cluster: O-acetylhomoserine sulfhydrylase; n=86;... 102 5e-21
UniRef50_Q1DAY0 Cluster: Cys/Met metabolism PLP-dependent enzyme... 102 5e-21
UniRef50_Q11MH2 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 102 5e-21
UniRef50_Q89XR2 Cluster: O-acetylhomoserine sulfhydrylase; n=24;... 102 6e-21
UniRef50_Q1IZN0 Cluster: Cystathionine gamma-synthase; n=1; Dein... 102 6e-21
UniRef50_Q979X4 Cluster: Cystathionine beta lyase / O-succinylho... 101 8e-21
UniRef50_Q338K0 Cluster: Cys/Met metabolism PLP-dependent enzyme... 101 1e-20
UniRef50_Q31RB7 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 101 1e-20
UniRef50_A3K0Q5 Cluster: O-succinylhomoserine sulfhydrylase; n=3... 101 1e-20
UniRef50_Q7VIG9 Cluster: O-acetylhomoserine (Thiol)-lyase MetY; ... 100 2e-20
UniRef50_Q5NPR0 Cluster: Cystathionine beta-lyases; n=5; Sphingo... 100 2e-20
UniRef50_Q28Q09 Cluster: Cystathionine gamma-synthase; n=7; Rhod... 100 2e-20
UniRef50_A3U7R8 Cluster: O-acetylhomoserine sulfhydrylase; n=8; ... 100 2e-20
UniRef50_Q59829 Cluster: Putative cystathionine gamma-lyase; n=8... 100 2e-20
UniRef50_Q5LWC9 Cluster: Cys/Met metabolism PLP-dependent enzyme... 100 2e-20
UniRef50_A7HB44 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 100 4e-20
UniRef50_Q5UZ20 Cluster: O-acetylhomoserine (Thiol)-lyase; n=10;... 100 4e-20
UniRef50_Q11C77 Cluster: Cystathionine beta-lyase; n=1; Mesorhiz... 99 6e-20
UniRef50_A7DB98 Cluster: Cystathionine gamma-synthase; n=2; Meth... 99 7e-20
UniRef50_Q49UL3 Cluster: Cystathionine beta-lyase cystathionine ... 98 1e-19
UniRef50_Q76K51 Cluster: O-acetyl-L-homoserine sulfhydrylase; n=... 98 1e-19
UniRef50_A4FF27 Cluster: Methionine gamma-lyase; n=1; Saccharopo... 97 2e-19
UniRef50_Q895W3 Cluster: O-acetylhomoserine sulfhydrylase; n=40;... 97 3e-19
UniRef50_Q2K0N3 Cluster: Cystathionine gamma-synthase protein; n... 97 3e-19
UniRef50_A1SMU4 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 97 3e-19
UniRef50_Q4Q511 Cluster: Cystathionine beta-lyase, putative; n=3... 96 4e-19
UniRef50_Q8J0B2 Cluster: Homocysteine synthase-like protein; n=2... 96 4e-19
UniRef50_Q8RI68 Cluster: Cystathionine gamma-synthase; n=1; Fuso... 96 5e-19
UniRef50_Q8KEI6 Cluster: Trans-sulfuration enzyme family protein... 96 5e-19
UniRef50_Q9KFD9 Cluster: Cystathionine gamma-synthase; n=3; Baci... 95 7e-19
UniRef50_Q8G436 Cluster: Possible cystathionine gamma lyase; n=3... 95 7e-19
UniRef50_A5MZA3 Cluster: O-acetyl-L-homoserine sulfhydrylase-rel... 95 7e-19
UniRef50_A0V4A3 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 95 7e-19
UniRef50_Q7WKX4 Cluster: Cys/Met metabolism PLP-dependent enzyme... 95 9e-19
UniRef50_A5MZ94 Cluster: O-acetyl-L-homoserine sulfhydrylase-rel... 95 1e-18
UniRef50_Q98LV9 Cluster: Methionine gamma lyase; n=4; Rhizobiale... 94 2e-18
UniRef50_Q0SFV6 Cluster: O-acetylhomoserine aminocarboxypropyltr... 93 3e-18
UniRef50_Q1NS60 Cluster: O-acetylhomoserine aminocarboxypropyltr... 93 4e-18
UniRef50_A6GJL1 Cluster: Methionine gamma-lyase; n=1; Plesiocyst... 93 4e-18
UniRef50_A1ZIW0 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 93 4e-18
UniRef50_A0JSB0 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 93 4e-18
UniRef50_Q1V2M7 Cluster: Cystathionine beta-lyase; n=2; Candidat... 93 5e-18
UniRef50_A7CL93 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 92 8e-18
UniRef50_A0JYV8 Cluster: Cystathionine gamma-synthase; n=8; Acti... 92 8e-18
UniRef50_A5ZYG7 Cluster: Putative uncharacterized protein; n=1; ... 91 1e-17
UniRef50_Q47S97 Cluster: Cystathionine gamma-synthase; n=1; Ther... 91 1e-17
UniRef50_Q7X137 Cluster: Cystathionine gamma lyase-like protein;... 91 1e-17
UniRef50_Q5K6Y9 Cluster: Cystathionine gamma-lyase, putative; n=... 91 1e-17
UniRef50_Q8NM00 Cluster: Cystathionine beta-lyases/cystathionine... 90 3e-17
UniRef50_Q7M9C8 Cluster: O-ACETYLHOMOSERINE SULFHYDRYLASE; n=1; ... 90 3e-17
UniRef50_A3PXR9 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 89 6e-17
UniRef50_Q97MT9 Cluster: O-acetylhomoserine sulfhydrylase; n=4; ... 89 8e-17
UniRef50_Q89V23 Cluster: O-acetylhomoserine sulfhydrylase; n=13;... 87 2e-16
UniRef50_P06106 Cluster: Protein MET17 [Includes: O-acetylhomose... 87 2e-16
UniRef50_UPI0000E0F9F5 Cluster: hypothetical protein OM2255_2257... 87 2e-16
UniRef50_Q2C9J3 Cluster: Cystathionine beta-lyase; n=1; Photobac... 86 6e-16
UniRef50_Q82YZ5 Cluster: Cystathionine gamma-synthase, putative;... 85 7e-16
UniRef50_Q28LE3 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 85 7e-16
UniRef50_A1I7W3 Cluster: O-acetylhomoserine aminocarboxypropyltr... 85 1e-15
UniRef50_Q0B5H9 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 84 2e-15
UniRef50_P43623 Cluster: Putative cystathionine beta-lyase; n=11... 84 2e-15
UniRef50_Q6W1U5 Cluster: Cystathionine gamma-synthase; n=2; Prot... 83 3e-15
UniRef50_Q3IV09 Cluster: O-acetylhomoserine sulfhydrylase; n=1; ... 83 5e-15
UniRef50_Q98KA4 Cluster: Probable cystathionine/methionine gamma... 81 2e-14
UniRef50_Q5LN68 Cluster: Cys/Met metabolism PLP-dependent enzyme... 80 3e-14
UniRef50_UPI0000E4882F Cluster: PREDICTED: hypothetical protein,... 80 4e-14
UniRef50_UPI0000E46EAD Cluster: PREDICTED: similar to methionine... 79 5e-14
UniRef50_Q181I0 Cluster: Methionine gamma-lyase; n=2; Clostridiu... 79 8e-14
UniRef50_UPI00003935FC Cluster: COG2873: O-acetylhomoserine sulf... 77 2e-13
UniRef50_A5G8H3 Cluster: O-acetylhomoserine aminocarboxypropyltr... 77 3e-13
UniRef50_Q8LAA9 Cluster: Putative uncharacterized protein; n=1; ... 77 3e-13
UniRef50_A4CKV8 Cluster: Cystathionine beta-lyase; n=11; Bactero... 76 5e-13
UniRef50_Q6F7Q9 Cluster: Putative cystathionine beta-lyase, PLP-... 75 8e-13
UniRef50_A1W861 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 75 8e-13
UniRef50_Q65SV5 Cluster: Putative uncharacterized protein; n=1; ... 75 1e-12
UniRef50_Q756K4 Cluster: AER250Cp; n=6; Saccharomycetales|Rep: A... 75 1e-12
UniRef50_Q1ITX7 Cluster: Cystathionine gamma-lyase; n=1; Acidoba... 74 2e-12
UniRef50_A1TP30 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 73 4e-12
UniRef50_A2Z703 Cluster: Putative uncharacterized protein; n=3; ... 72 7e-12
UniRef50_Q64XN5 Cluster: O-acetylhomoserine sulfhydrylase; n=3; ... 71 1e-11
UniRef50_A5BR77 Cluster: Putative uncharacterized protein; n=1; ... 67 2e-10
UniRef50_A4S3Y0 Cluster: Putative 2nd cystathione gamma synthase... 66 4e-10
UniRef50_A5KK19 Cluster: Putative uncharacterized protein; n=1; ... 66 6e-10
UniRef50_O42851 Cluster: Uncharacterized trans-sulfuration enzym... 66 6e-10
UniRef50_Q9SGU9 Cluster: F1N19.23; n=7; Magnoliophyta|Rep: F1N19... 65 1e-09
UniRef50_A1D936 Cluster: Cystathionine gamma-synthase; n=21; Asc... 64 2e-09
UniRef50_Q45278 Cluster: Aminotransferase and dihydrorhizobitoxi... 64 3e-09
UniRef50_P38716 Cluster: Uncharacterized trans-sulfuration enzym... 63 3e-09
UniRef50_A6MLE3 Cluster: Cystathionine gamma-lyase-like protein;... 62 6e-09
UniRef50_Q3A8R5 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 61 1e-08
UniRef50_Q2UJR0 Cluster: Cystathionine beta-lyases/cystathionine... 60 2e-08
UniRef50_A2BPN5 Cluster: Possible Cystathionine gamma-synthase; ... 58 1e-07
UniRef50_A7DHV1 Cluster: O-acetylhomoserine aminocarboxypropyltr... 58 1e-07
UniRef50_P38675 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 57 2e-07
UniRef50_Q3AI46 Cluster: Possible cystathionine gamma-synthase; ... 56 7e-07
UniRef50_A6Q4H8 Cluster: O-acetylhomoserine sulfhydrylase; n=3; ... 56 7e-07
UniRef50_A3JA39 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 56 7e-07
UniRef50_Q0V7G5 Cluster: Putative uncharacterized protein; n=1; ... 53 4e-06
UniRef50_A1CUZ3 Cluster: Homocysteine synthase, putative; n=1; N... 51 1e-05
UniRef50_O74314 Cluster: Probable cystathionine gamma-synthase (... 51 1e-05
UniRef50_A6R1N2 Cluster: Cystathionine gamma-synthase; n=1; Ajel... 50 4e-05
UniRef50_Q2U598 Cluster: Cystathionine beta-lyases/cystathionine... 49 6e-05
UniRef50_Q4WFS7 Cluster: Cystathionine beta-lyase; n=2; Pezizomy... 48 1e-04
UniRef50_A5W0L6 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 48 1e-04
UniRef50_Q6C8S4 Cluster: Similar to tr|Q86ZL4 Podospora anserina... 48 1e-04
UniRef50_A3LX62 Cluster: Predicted protein; n=6; Saccharomycetal... 48 1e-04
UniRef50_Q00ZR7 Cluster: Cystathionine gamma-synthase; n=1; Ostr... 48 2e-04
UniRef50_A4E6V5 Cluster: Putative uncharacterized protein; n=1; ... 45 0.001
UniRef50_Q6CWG2 Cluster: Similar to sp|P47164 Saccharomyces cere... 42 0.009
UniRef50_P47164 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 41 0.016
UniRef50_Q2U6Q0 Cluster: Cystathionine beta-lyases/cystathionine... 40 0.027
UniRef50_Q8XRQ0 Cluster: Probable cystathionine beta-lyases/cyst... 39 0.063
UniRef50_Q2UI88 Cluster: Cystathionine beta-lyases/cystathionine... 39 0.063
UniRef50_Q8F9S7 Cluster: Cystathionine gamma-synthase; n=4; Lept... 38 0.19
UniRef50_A7DA75 Cluster: O-acetylhomoserine sulfhydrylase-like p... 38 0.19
UniRef50_UPI000023F0A1 Cluster: hypothetical protein FG08909.1; ... 37 0.26
UniRef50_Q30Q15 Cluster: Outer membrane cobalamin receptor prote... 36 0.45
UniRef50_Q2HHZ6 Cluster: Putative uncharacterized protein; n=1; ... 36 0.45
UniRef50_Q65SV6 Cluster: Putative uncharacterized protein; n=1; ... 35 1.0
UniRef50_Q83YE3 Cluster: Shy7; n=2; Actinomycetales|Rep: Shy7 - ... 35 1.4
UniRef50_Q4P760 Cluster: Putative uncharacterized protein; n=1; ... 34 2.4
UniRef50_Q5CWP3 Cluster: Large protein having a MATH plus possib... 33 3.1
UniRef50_Q0UR78 Cluster: Putative uncharacterized protein; n=1; ... 33 4.2
UniRef50_Q12198 Cluster: Putative cystathionine gamma-synthase Y... 33 4.2
UniRef50_Q872Z1 Cluster: Related to O-succinylhomoserine (Thiol)... 33 5.5
UniRef50_UPI00015C6118 Cluster: hypothetical protein CKO_04986; ... 32 7.3
UniRef50_UPI000023F307 Cluster: hypothetical protein FG00503.1; ... 32 7.3
UniRef50_Q7Q534 Cluster: ENSANGP00000020904; n=1; Anopheles gamb... 32 7.3
UniRef50_UPI0000D55B6E Cluster: PREDICTED: similar to CG6475-PA;... 32 9.6
UniRef50_Q98A35 Cluster: Msl6173 protein; n=1; Mesorhizobium lot... 32 9.6
UniRef50_Q6W7W2 Cluster: Small ribosomal protein 4; n=21; Embryo... 32 9.6
UniRef50_A0DWE3 Cluster: Chromosome undetermined scaffold_67, wh... 32 9.6
UniRef50_Q6FK75 Cluster: Similar to sp|P47164 Saccharomyces cere... 32 9.6
UniRef50_A5DEV4 Cluster: Putative uncharacterized protein; n=1; ... 32 9.6
UniRef50_A1DJG8 Cluster: Cystathionine gamma-synthase; n=1; Neos... 32 9.6
>UniRef50_Q17DR1 Cluster: Cystathionine beta-lyase; n=6;
Coelomata|Rep: Cystathionine beta-lyase - Aedes aegypti
(Yellowfever mosquito)
Length = 438
Score = 246 bits (601), Expect = 3e-64
Identities = 117/175 (66%), Positives = 141/175 (80%), Gaps = 1/175 (0%)
Frame = +1
Query: 16 SDVIMGAAIVNDGVIAAKLRFLQ-NAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLII 192
S +++ I D ++ + +L A GIVPSP DCYLVNRSLKTLA+RME+HK +SL I
Sbjct: 258 SHIVVNDCICKDTRVSRFMHYLSPTAAGIVPSPFDCYLVNRSLKTLALRMERHKSNSLAI 317
Query: 193 ANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFT 372
A +L KHPKV+ VLHPGLPSHPQHE+ KKQT GHSG+ SF GG++ES KFL SL++FT
Sbjct: 318 AKFLEKHPKVERVLHPGLPSHPQHELAKKQTYGHSGIMSFYIKGGMEESTKFLQSLEVFT 377
Query: 373 LAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LAESLGGYESLAE+PSVMTHASVP E RA LGITD+L+R+SVGLED +DLI DL+
Sbjct: 378 LAESLGGYESLAEVPSVMTHASVPPEHRALLGITDNLIRISVGLEDADDLIVDLK 432
Score = 48.8 bits (111), Expect = 8e-05
Identities = 21/29 (72%), Positives = 25/29 (86%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQN 87
YMNGHSDVIMGAAI+ND + +L+FLQN
Sbjct: 219 YMNGHSDVIMGAAIMNDEALYEQLKFLQN 247
>UniRef50_Q8VCN5 Cluster: Cystathionine gamma-lyase; n=39;
Eukaryota|Rep: Cystathionine gamma-lyase - Mus musculus
(Mouse)
Length = 398
Score = 235 bits (576), Expect = 4e-61
Identities = 108/179 (60%), Positives = 140/179 (78%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YMNGHSDV+MG VN + ++LRFLQN++G VPSP DCYL R LKTL +RME+H K+
Sbjct: 212 YMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKN 271
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L +P+V+ V++PGLPSHPQHE+ K+Q SG G+ SF G L+ + FL +L
Sbjct: 272 GMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNL 331
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+FTLAESLGGYESLAELP++MTHASVP + RA LGI D+L+RLSVGLED +DL+ DL+
Sbjct: 332 KLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLD 390
>UniRef50_UPI000155C3C4 Cluster: PREDICTED: similar to
cystathionase; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to cystathionase - Ornithorhynchus
anatinus
Length = 382
Score = 231 bits (566), Expect = 6e-60
Identities = 106/179 (59%), Positives = 139/179 (77%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YMNGHSDV+MG VN + +L+FLQN++G VPSP DCYL NR LKTL IRM+QH ++
Sbjct: 43 YMNGHSDVVMGLVSVNSEDLYQRLQFLQNSLGAVPSPFDCYLCNRGLKTLQIRMKQHFQN 102
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
L +A +L P+V+ V+ PGLPSHPQHE+ K+Q +G G+ +F G L+ + FL +L
Sbjct: 103 GLAVAKYLESDPRVEKVIFPGLPSHPQHELVKRQCTGCPGMITFYIKGNLQHAETFLKNL 162
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+F+LAESLGGYESLAELP++MTHASVP E R LGI+++L+RLSVGLEDT+DL+ DL+
Sbjct: 163 KLFSLAESLGGYESLAELPAIMTHASVPKEDRDVLGISETLIRLSVGLEDTDDLLEDLD 221
>UniRef50_P32929 Cluster: Cystathionine gamma-lyase; n=38; cellular
organisms|Rep: Cystathionine gamma-lyase - Homo sapiens
(Human)
Length = 405
Score = 225 bits (550), Expect = 5e-58
Identities = 105/179 (58%), Positives = 139/179 (77%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YMNGHSDV+MG VN + +LRFLQN++G VPSP+DCYL NR LKTL +RME+H K+
Sbjct: 213 YMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKN 272
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L +P V+ V++PGLPSHPQHE+ K+Q +G +G+ +F G L+ + FL +L
Sbjct: 273 GMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNL 332
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+FTLAESLGG+ESLAELP++MTHASV R LGI+D+L+RLSVGLED EDL+ DL+
Sbjct: 333 KLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLD 391
>UniRef50_Q129P6 Cluster: Cystathionine gamma-synthase; n=11;
cellular organisms|Rep: Cystathionine gamma-synthase -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 381
Score = 201 bits (490), Expect = 9e-51
Identities = 93/179 (51%), Positives = 127/179 (70%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDVI GA ++ND + +L+FLQNA+G VP P+DC+LV R +KTLA+RM QH +
Sbjct: 196 YLGGHSDVIGGALVMNDEALYQELKFLQNAVGAVPGPLDCFLVLRGIKTLAVRMRQHCDN 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A L HP+VK + +PGL S P H + +Q + G+ S GG++ + +F +
Sbjct: 256 ALQLARHLAAHPEVKQLAYPGLESSPHHALASRQMRAYGGMISLELQGGVERNIRFTTQT 315
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+F LAESLGG ESL LP+VMTHA++P QR Q G+ D+LVRLSVGLED EDLI D++
Sbjct: 316 KLFALAESLGGVESLIGLPTVMTHAAIPPAQRQQAGLPDALVRLSVGLEDIEDLIEDVD 374
>UniRef50_Q23CV0 Cluster: Cystathionine beta-lyase; n=3;
Oligohymenophorea|Rep: Cystathionine beta-lyase -
Tetrahymena thermophila SB210
Length = 409
Score = 200 bits (489), Expect = 1e-50
Identities = 97/179 (54%), Positives = 126/179 (70%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDVIMGA + N + KL + + G PS DCYL R LKTL RM+ H ++
Sbjct: 220 YIGGHSDVIMGALVFNGKEMKDKLFYSSISFGGCPSTFDCYLAVRGLKTLESRMKIHCRN 279
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A WL +HP ++ V+ PGL SHPQHE+ KKQ G G+ SF+ GG E+ KFLSS
Sbjct: 280 AYSVAKWLEQHPLIEKVIFPGLESHPQHELAKKQQRGFGGMISFLLKGGKAEAFKFLSSC 339
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ TLAESLGG E+L E P+ MTHASVPAE RA+LGITD+ +RLS G+ED ED++AD++
Sbjct: 340 KLATLAESLGGVETLIEHPASMTHASVPAEVRAKLGITDNFIRLSCGVEDVEDIMADID 398
>UniRef50_Q838Z2 Cluster: Cystathionine beta-lyase; n=8;
Bacteria|Rep: Cystathionine beta-lyase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 378
Score = 193 bits (470), Expect = 2e-48
Identities = 96/179 (53%), Positives = 124/179 (69%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G + N A K+ FLQNA+G V P D +LV RSLKTL +RM H ++
Sbjct: 196 YLGGHSDVVSGLVVTNHPESAEKIAFLQNAIGAVLGPHDSWLVQRSLKTLGVRMAAHAQN 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L HP V V +PGL SHP HEI +KQ SG SG+ SF + ++ F+ +L
Sbjct: 256 AQKIAEFLEAHPAVATVYYPGLASHPGHEIAQKQMSGFSGMISF-ELAKDEQVVPFVEAL 314
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+IFTLAESLGG ESL E+P++MTHAS+P E R +GI D L+RLSVG+E EDL+ADLE
Sbjct: 315 EIFTLAESLGGVESLIEVPAIMTHASIPKENREAVGIKDGLIRLSVGIEAVEDLLADLE 373
>UniRef50_P56069 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=24;
Bacteria|Rep: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase) -
Helicobacter pylori (Campylobacter pylori)
Length = 380
Score = 189 bits (461), Expect = 3e-47
Identities = 90/179 (50%), Positives = 122/179 (68%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G N+ +A ++ F QNA+G V P D +L+ R +KTL +RME H+K+
Sbjct: 196 YLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKN 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A +L KHPKV+ V +PGLP+HP +E+ KKQ G SG+ SF + E+ F+ SL
Sbjct: 256 ALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFT-LKNDSEAVAFVESL 314
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+F L ESLGG ESL +P+ MTHA +P QR GI D LVRLSVG+E +DL+ DLE
Sbjct: 315 KLFILGESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLE 373
>UniRef50_Q8KEI8 Cluster: Trans-sulfuration enzyme family protein;
n=8; Chlorobiaceae|Rep: Trans-sulfuration enzyme family
protein - Chlorobium tepidum
Length = 380
Score = 182 bits (444), Expect = 3e-45
Identities = 87/178 (48%), Positives = 118/178 (66%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDVI GA + +D + +R Q A G +P P DC+L++R +KTL IRME+H+K+
Sbjct: 196 YLGGHSDVIGGAVVASDDNLNLTIRNYQGAAGAIPGPWDCWLISRGIKTLKIRMEEHQKN 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A L KHP V V++PGL SHPQHE+ K+Q SG G+ + GGL K + SL
Sbjct: 256 ALHLARALEKHPAVSRVIYPGLESHPQHELAKRQMSGFGGMLTIALKGGLPAVRKMIESL 315
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+F +A+SLGG ESL P+ MT + +R + TD LVRLS+GLE+ EDL ADL
Sbjct: 316 KLFVIADSLGGVESLVASPARMTLGPLSQAERDRRACTDDLVRLSIGLENAEDLEADL 373
>UniRef50_Q5UZS6 Cluster: Cystathionine gamma-synthase; n=3;
cellular organisms|Rep: Cystathionine gamma-synthase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 411
Score = 182 bits (444), Expect = 3e-45
Identities = 86/180 (47%), Positives = 125/180 (69%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQN-AMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGHSD + GA I +D +A ++ F Q A+G + +P D YL++R +KTL +RM +H+
Sbjct: 224 YLNGHSDAVGGALITDDPEVAERVEFRQQIALGNMLAPFDSYLISRGIKTLGVRMTRHEN 283
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
+++ +A +L H V+ V +PGL SHPQH++ ++Q G GV SF G + ++ +FL +
Sbjct: 284 NAMALAQYLDDHEHVETVHYPGLESHPQHDLAREQMQGFGGVLSFELAGDMADAKQFLEA 343
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L+ TLA SLGG ESLAELP+ MTH + R +LGI+D+L+RLSVG+ED EDL ADLE
Sbjct: 344 LETVTLAVSLGGVESLAELPAAMTHEPLSPAARDELGISDTLIRLSVGIEDVEDLRADLE 403
>UniRef50_Q1INQ0 Cluster: Cystathionine gamma-synthase; n=2;
Bacteria|Rep: Cystathionine gamma-synthase -
Acidobacteria bacterium (strain Ellin345)
Length = 385
Score = 179 bits (435), Expect = 4e-44
Identities = 81/179 (45%), Positives = 121/179 (67%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++NGHSD + G + + KL F+Q ++G + SP + +L+ R +KTLA+RM+QH +S
Sbjct: 202 FLNGHSDGLGGVLVCTTKEQSEKLAFIQKSVGAIMSPFESWLILRGVKTLAVRMKQHDES 261
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++A++L K K+K V +PGLP HPQHE+ K+Q +G + +F G L + K L +
Sbjct: 262 GRVVADFLAKQKKIKKVFYPGLPDHPQHELAKQQMTGFGALITF-ETGSLNNAKKLLKRV 320
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ TL ESLGG E+L P+ MTHA++ + RA +G+TD +VR+SVG+ED EDLI DLE
Sbjct: 321 KVCTLGESLGGVETLISHPATMTHAALGEKGRAAIGLTDGMVRISVGIEDVEDLITDLE 379
>UniRef50_P46807 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=42;
cellular organisms|Rep: Cystathionine gamma-synthase (EC
2.5.1.48) (CGS) (O-succinylhomoserine (thiol)-lyase) -
Mycobacterium leprae
Length = 388
Score = 179 bits (435), Expect = 4e-44
Identities = 88/179 (49%), Positives = 113/179 (63%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ GA + ND + FLQN G VPSP D YL R LKTL +RM++H ++
Sbjct: 209 YIGGHSDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDAYLTMRGLKTLVLRMQRHNEN 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ +A +L HP V VL+PGLPSHP HE+ +Q G G+ S G + +
Sbjct: 269 AITVAEFLAGHPSVSAVLYPGLPSHPGHEVAARQMRGFGGMVSLRMRAGRLAAQDLCART 328
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+FTLAESLGG ESL E PS MTHAS +QL + D LVRLSVG+ED DL+ DL+
Sbjct: 329 KVFTLAESLGGVESLIEQPSAMTHASTTG---SQLEVPDDLVRLSVGIEDVGDLLCDLK 384
>UniRef50_Q4A0K3 Cluster: Cystathionine gamma-synthase; n=4;
Bacteria|Rep: Cystathionine gamma-synthase -
Staphylococcus saprophyticus subsp. saprophyticus
(strain ATCC 15305 /DSM 20229)
Length = 381
Score = 177 bits (432), Expect = 1e-43
Identities = 85/179 (47%), Positives = 120/179 (67%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G +D +A +L F+QN+ G V P D YL+ R +KTL +RMEQ +++
Sbjct: 197 YIGGHSDVVAGLVATSDAELAERLGFIQNSTGGVLGPQDSYLLIRGIKTLGLRMEQVQRN 256
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L I + L +H VK V HP + H H+I + Q+ GH+GV +F V ++ + K +S
Sbjct: 257 TLAIIDMLQQHSAVKQVFHPSISDHLNHDIHEAQSEGHTGVVAF-EVADIESAKKVISES 315
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
FTLAESLG ESL +P++MTHAS+P + R + GI D LVRLSVG+EDT+DL+ DLE
Sbjct: 316 HYFTLAESLGAVESLISVPALMTHASIPKDIREKEGIADGLVRLSVGIEDTKDLVEDLE 374
>UniRef50_A6QZA3 Cluster: Cystathionine gamma-lyase; n=1;
Ajellomyces capsulatus NAm1|Rep: Cystathionine
gamma-lyase - Ajellomyces capsulatus NAm1
Length = 457
Score = 175 bits (426), Expect = 5e-43
Identities = 86/180 (47%), Positives = 116/180 (64%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSDV+MG A+ N + +L FLQNA+G VPS DC+L +R LKTL +R + K+
Sbjct: 257 YINGHSDVLMGVAVFNSPTLHERLSFLQNAIGAVPSAFDCWLAHRGLKTLHLRAREASKN 316
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ--TSGHSGVFSFVHVGGLKESNKFLS 354
+ IAN L P V V +PG+ SHPQ ++ KQ G+ SF GG+ + +F
Sbjct: 317 ATAIANALESSPHVIAVNYPGIKSHPQRDLALKQHRDGMGGGMLSFRIKGGVAAAERFCQ 376
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+F LAESLGG ESL E+P MTHA +P EQR G+ + LVR+S G+ED+ DL+AD+
Sbjct: 377 ETKLFVLAESLGGVESLVEVPGSMTHAGIPKEQREAAGVFEDLVRVSCGIEDSADLVADV 436
>UniRef50_Q74EL7 Cluster: Cystathionine beta-lyase; n=5;
Bacteria|Rep: Cystathionine beta-lyase - Geobacter
sulfurreducens
Length = 378
Score = 171 bits (417), Expect = 7e-42
Identities = 79/179 (44%), Positives = 120/179 (67%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++NGHSDV+ G A+V D + ++RF+QNA G + P D +LV R +KTL +RME+ +
Sbjct: 196 FLNGHSDVVCGFAVVRDPELGQRIRFIQNAFGAILGPQDSWLVLRGIKTLRVRMEESQAG 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ IANWL +V V +PGLP HP H+I +Q+SG V SF + ++ + + L +
Sbjct: 256 AVKIANWLAGEKRVSRVFYPGLPDHPGHDIHGRQSSGPGAVLSFT-LDTVETTRRLLEGM 314
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ A SLGG ES+ P+ M+HA++P +RA GI D+LVRLSVGLED +DL+A+++
Sbjct: 315 RLAAFAVSLGGVESIISYPARMSHAAMPPAERAARGIGDTLVRLSVGLEDADDLLAEMD 373
>UniRef50_A5E0C2 Cluster: Cystathionine gamma-lyase; n=6; cellular
organisms|Rep: Cystathionine gamma-lyase - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 406
Score = 171 bits (417), Expect = 7e-42
Identities = 87/187 (46%), Positives = 122/187 (65%), Gaps = 8/187 (4%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSDV+MG ND + K RFLQNA+G +PSP D +L +R LKTL +R+ Q S
Sbjct: 210 YINGHSDVVMGVLATNDSELHEKFRFLQNAIGSIPSPFDSWLAHRGLKTLHLRLRQASNS 269
Query: 181 SLIIANWL---LKHPKVKDVLH---PGLPSHPQHEITKKQTSGH--SGVFSFVHVGGLKE 336
+ IA +L + + ++H PGL +H H++ +Q G+ SF GG K
Sbjct: 270 AQKIAEFLQSKIDNHNDGSIIHVNYPGLSTHKNHDVVSRQHRDGLGGGMISFRIRGGAKA 329
Query: 337 SNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTE 516
++ F SS ++FTLAESLGG ESL E+P++MTH +P E+R G+ D LVR+SVG+EDT+
Sbjct: 330 ASIFTSSTQLFTLAESLGGIESLIEVPAIMTHGGIPKEEREANGVYDDLVRVSVGIEDTD 389
Query: 517 DLIADLE 537
DLIAD++
Sbjct: 390 DLIADIQ 396
>UniRef50_A7HF96 Cluster: Cystathionine gamma-synthase; n=7;
Bacteria|Rep: Cystathionine gamma-synthase -
Anaeromyxobacter sp. Fw109-5
Length = 426
Score = 171 bits (415), Expect = 1e-41
Identities = 85/182 (46%), Positives = 119/182 (65%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDG--VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHK 174
Y+NGHSDV+ GA + G + +++ + N +G SP DC+LV R LKTL +RM H+
Sbjct: 237 YLNGHSDVVGGAVVAAPGRSALVQRIQSVNNLLGTSQSPHDCFLVLRGLKTLLLRMRAHE 296
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES-NKFL 351
+ +A++L HP V V +PGL SHPQH + ++Q +G G+ SF G +E + L
Sbjct: 297 AGARAVADFLAAHPAVAKVHYPGLASHPQHALARRQQTGFGGMVSFELADGRRERVDHVL 356
Query: 352 SSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
+L+ FTLAESLGG ESL P+ MTHAS+ E R + GITD ++RLSVG+E+ DLIAD
Sbjct: 357 RTLRWFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDGVIRLSVGIEEPADLIAD 416
Query: 532 LE 537
L+
Sbjct: 417 LD 418
>UniRef50_Q9EWF9 Cluster: Cystathionine gamma-synthase; n=6;
Bacteria|Rep: Cystathionine gamma-synthase -
Streptomyces coelicolor
Length = 386
Score = 169 bits (411), Expect = 3e-41
Identities = 86/179 (48%), Positives = 115/179 (64%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YM GHSDV+ GA IV D + +L F QNAMG V P D +LV R KTLA+RM++H ++
Sbjct: 207 YMGGHSDVVGGALIVGDQELGEELAFHQNAMGAVAGPFDSWLVLRGTKTLAVRMDRHSEN 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A+ L +H +V VL+PGLP HP HE+ KQ G+ SF GG + + + +
Sbjct: 267 ATKVADMLSRHARVTSVLYPGLPEHPGHEVAAKQMKAFGGMVSFRVEGGEQAAVEVCNRA 326
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+FTL ESLGG ESL E P MTHAS + L + LVRLSVG+E+ +DL+ADL+
Sbjct: 327 KVFTLGESLGGVESLIEHPGRMTHASAAG---SALEVPADLVRLSVGIENADDLLADLQ 382
>UniRef50_Q97M10 Cluster: Cystathionine gamma-synthase; n=15;
Bacteria|Rep: Cystathionine gamma-synthase - Clostridium
acetobutylicum
Length = 384
Score = 169 bits (410), Expect = 5e-41
Identities = 80/179 (44%), Positives = 119/179 (66%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D + G I+ND + KLRF+QN++G V +P D +L+ R +KTL IR+++ +++
Sbjct: 202 YLCGHNDALAGFVILNDERLIEKLRFIQNSVGAVLAPFDSWLILRGIKTLHIRLDRQQEN 261
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ IAN+L KH K+ VL+PGL H H+I K + SG + SF +V + K L S+
Sbjct: 262 AIKIANFLKKHKKITKVLYPGLEEHVGHDILKSEASGFGAMISF-YVDSKETVEKVLESV 320
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ AESLGG ESL P THA +P + R +LG+TD L+R SVG+E+ +DLI DL+
Sbjct: 321 KVIIFAESLGGVESLITYPYTQTHADIPDDIRKRLGVTDKLLRFSVGIENVDDLIKDLD 379
>UniRef50_Q6N7A1 Cluster: Cystathionine gamma-lyase; n=52; cellular
organisms|Rep: Cystathionine gamma-lyase -
Rhodopseudomonas palustris
Length = 390
Score = 163 bits (397), Expect = 2e-39
Identities = 78/179 (43%), Positives = 112/179 (62%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD++ GA +V D +A KL+FLQNA G + P +L R +KTL +R+++H +
Sbjct: 206 YIGGHSDIVGGAIVVRDPDLAQKLQFLQNATGGILDPFSSFLALRGIKTLPLRVQRHSSN 265
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A WL HPK++ V++PGL SHPQH + +Q G G+ + ++ LS
Sbjct: 266 ALAVARWLDAHPKIERVVYPGLNSHPQHALAVRQMDGGGGMVAAYLKADEQQVVDVLSRF 325
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++F LAESLG ESL P M+H S+P R IT +L+RLS+G+ED EDL DLE
Sbjct: 326 RLFALAESLGAVESLVGQPWTMSHGSLPEADRLAREITPNLIRLSIGIEDVEDLTDDLE 384
>UniRef50_Q8XNZ9 Cluster: Cystathionine gamma-synthase; n=7;
Bacteria|Rep: Cystathionine gamma-synthase - Clostridium
perfringens
Length = 384
Score = 163 bits (396), Expect = 2e-39
Identities = 77/179 (43%), Positives = 118/179 (65%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD++ G +V D + K+ F+QN+ G + P D +L+ R +KTL++RM++H+ +
Sbjct: 194 YLGGHSDLVAGLVVVKDEELGEKIHFIQNSTGGILQPFDSFLLIRGIKTLSVRMDRHELN 253
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA L + +V +PGL +H H+I KKQ SG G+ SF + KF +SL
Sbjct: 254 ANFIAEKLGDLEGIDNVYYPGLKTHIGHDIQKKQASGFGGIISFT-LNKKYNYEKFFNSL 312
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ T ESLGG ESLA P+ MTHA++P E R ++GITD L+R+SVG+ED ED++ D++
Sbjct: 313 ELITFGESLGGVESLACHPASMTHAAMPLELRERIGITDRLIRISVGIEDKEDILEDIQ 371
>UniRef50_Q67R76 Cluster: Cystathionine gamma-lyase; n=13;
Bacteria|Rep: Cystathionine gamma-lyase -
Symbiobacterium thermophilum
Length = 401
Score = 162 bits (394), Expect = 4e-39
Identities = 83/180 (46%), Positives = 121/180 (67%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIA-AKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
++ GH DV+ G A+ V+A + L+N GI+ SP D +L+ R LKTLAIRME+H +
Sbjct: 211 FIGGHGDVVAGLAVGPAEVMARVRSTTLKNFGGIL-SPFDAWLLLRGLKTLAIRMERHSE 269
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++L +A +L +HP V V +PGL S P HE+ ++Q G G+ SF +GG++ L+
Sbjct: 270 NALKVARYLEQHPLVMRVYYPGLESSPYHELARRQMDGFGGLLSFELMGGMEAGRTLLNH 329
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+++ T+A SLG ++L + P+ MTHA VP E RA GI+D LVRLSVGLED +D+IADL+
Sbjct: 330 VRLCTVAVSLGDTDTLIQHPASMTHAVVPPEARAAAGISDGLVRLSVGLEDADDIIADLD 389
>UniRef50_A1ZDN6 Cluster: Cystathionine beta-lyase; n=1; Microscilla
marina ATCC 23134|Rep: Cystathionine beta-lyase -
Microscilla marina ATCC 23134
Length = 380
Score = 161 bits (391), Expect = 9e-39
Identities = 83/179 (46%), Positives = 116/179 (64%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+ GA I + G++A +++ G + CYL+ RSLKTLA+R+ Q +
Sbjct: 199 YLGGHSDLSCGAIIGSKGLVA-QIKSTATHFGGNLNAQTCYLLERSLKTLALRVRQQTYN 257
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A ++ KHPKVK V +PGL SHPQH+I K+Q G+ + + G E+ +FL L
Sbjct: 258 AQKLAEFMEKHPKVKKVHYPGLESHPQHDIAKRQMEGYGAMLAVELHGNADETRQFLRKL 317
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
KI T A SLGG E+ P+ +HA + AEQR LGI+DSL+R+SVG+E TEDLIAD E
Sbjct: 318 KIVTPAMSLGGVETSICEPATTSHAKISAEQRQNLGISDSLLRISVGIEATEDLIADFE 376
>UniRef50_Q5L1M8 Cluster: Cystathionine beta-lyase; n=42;
Bacteria|Rep: Cystathionine beta-lyase - Geobacillus
kaustophilus
Length = 393
Score = 159 bits (387), Expect = 3e-38
Identities = 80/179 (44%), Positives = 115/179 (64%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GHSDV+ G A+V D + +L LQNA G V D +LV R LKTL +R++Q +S
Sbjct: 200 FLAGHSDVVAGLAVVKDEELGKELYKLQNAFGAVLGVQDAWLVLRGLKTLHVRLKQSSES 259
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L HPKV+ V +PGL +HP H+I + Q +G V SF + + + F+ ++
Sbjct: 260 AAAIAKYLACHPKVEKVYYPGLENHPGHDIQRHQAAGFGAVLSF-RLADEEAARTFVRNV 318
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ A SLG ES+ P+ M+HA++P E+R + GITD L+RLSVGLED DLIAD E
Sbjct: 319 RLPVFAVSLGAVESILSHPAKMSHAAMPKEERLRRGITDGLLRLSVGLEDVNDLIADFE 377
>UniRef50_Q8G805 Cluster: Cystathionine beta-lyase; n=2;
Bifidobacterium longum|Rep: Cystathionine beta-lyase -
Bifidobacterium longum
Length = 412
Score = 158 bits (384), Expect = 7e-38
Identities = 82/178 (46%), Positives = 116/178 (65%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV G +V+ +A+++ F QN +G V +P +C V R ++TLA+RM++ +++
Sbjct: 204 YLAGHSDVNAGLVVVSGEDLASRVYFAQNRLGGVLAPAECDAVRRGIQTLALRMDRQQEN 263
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +LL HP VK V +PGLP + K G GV SF V G+ ++ L++L
Sbjct: 264 ANAIARYLLVHPLVKAVHYPGLPGAGDQRLAAKGLKGAGGVLSFEVVPGVDPAD-VLNNL 322
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+F LA SLG ESLAELP MTH +P E+R ++GITD LVRL+VG+ED DLI DL
Sbjct: 323 HLFRLAVSLGAVESLAELPCRMTHFELPREERLKIGITDELVRLAVGIEDANDLIEDL 380
>UniRef50_Q8R9M2 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=5; Clostridia|Rep: Cystathionine
beta-lyases/cystathionine gamma-synthases -
Thermoanaerobacter tengcongensis
Length = 394
Score = 158 bits (383), Expect = 9e-38
Identities = 81/180 (45%), Positives = 110/180 (61%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRF-LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+ GH D + G AI D L+F G V SP + +L+ R +KTL +RM QH+K
Sbjct: 209 YICGHGDALGGVAISKDEAYIHYLKFDYMCEFGGVMSPFNAWLMLRGIKTLGLRMRQHEK 268
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
+++ +A +L +HPKVK+VL+PGL S H I KKQ G + SF GG KE +F+
Sbjct: 269 NAMEVAKFLSRHPKVKNVLYPGLESFKGHGIAKKQMRGFGAIISFEIEGGRKELEEFIKG 328
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LK+ LA SLG E+L E+PS+MTH P E+ G ++ VR+SVGLED D+I DLE
Sbjct: 329 LKLCQLAVSLGDAETLVEVPSIMTHRGYPKEKLEDFGFKENTVRISVGLEDYNDIIEDLE 388
>UniRef50_A1A0Q5 Cluster: Cystathionine beta-lyase; n=2;
Bifidobacterium adolescentis|Rep: Cystathionine
beta-lyase - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 411
Score = 157 bits (382), Expect = 1e-37
Identities = 81/178 (45%), Positives = 117/178 (65%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHS+V G +V D + ++ F QN +G V +P +C V R ++TLA+RM++ +++
Sbjct: 207 YLAGHSEVNAGLVVVKDDELGKRVYFAQNRLGGVLAPNECDSVRRGIQTLALRMDRQQEN 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ I+++LL HP VK V +PGLP H ++E+ G V SF V G+ ++ L +L
Sbjct: 267 ARAISSYLLLHPLVKSVHYPGLPGH-EYELASNGLKGGGAVLSFEVVPGVDPAD-VLDNL 324
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
IF LA SLG ESLAELP MTH +P E+R ++GITD LVRL+VG+ED +DLI DL
Sbjct: 325 HIFRLAVSLGAVESLAELPCRMTHFELPREERLKVGITDELVRLAVGIEDKQDLIEDL 382
>UniRef50_Q8TMW7 Cluster: Methionine gamma-lyase; n=3;
Methanosarcina|Rep: Methionine gamma-lyase -
Methanosarcina acetivorans
Length = 406
Score = 157 bits (380), Expect = 2e-37
Identities = 78/179 (43%), Positives = 116/179 (64%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D ++G +V L + G + + +L R LKTL IRME+H ++
Sbjct: 211 YIGGHAD-LLGGIVVGSRDFMKSLGKVVGYTGGIMGLHEAWLCIRGLKTLHIRMERHAEN 269
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +AN+L HP V+ V +PGL +HPQHE+ KKQ SG+ G+ SF GG++ + + S+
Sbjct: 270 ALTVANFLEAHPTVEWVRYPGLSNHPQHEVAKKQMSGYGGMLSFEIRGGVEAGRRLMDSV 329
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ +LA SLG ++L + P+ MTHA +P R ++GI D LVRLSVG+ED ED+IADLE
Sbjct: 330 RLCSLAVSLGATDTLIQHPASMTHACIPGHIRNKVGIKDGLVRLSVGIEDPEDIIADLE 388
>UniRef50_P53780 Cluster: Cystathionine beta-lyase, chloroplast
precursor; n=11; cellular organisms|Rep: Cystathionine
beta-lyase, chloroplast precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 464
Score = 157 bits (380), Expect = 2e-37
Identities = 75/179 (41%), Positives = 114/179 (63%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GHSDV+ G V +A ++ FLQN+ G +P DC+L R +KT+A+R+E+ +++
Sbjct: 279 FIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQEN 338
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L HP+VK V + GLP HP H + Q G VFSF+ G + S + +
Sbjct: 339 ARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFI-TGSVALSKHLVETT 397
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K F++A S G +SL +P M+HAS+PAE R G+T+ LVR+S G+ED +DLI+DL+
Sbjct: 398 KYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLD 456
>UniRef50_Q2IEA5 Cluster: Cystathionine gamma-synthase; n=1;
Anaeromyxobacter dehalogenans 2CP-C|Rep: Cystathionine
gamma-synthase - Anaeromyxobacter dehalogenans (strain
2CP-C)
Length = 426
Score = 156 bits (378), Expect = 3e-37
Identities = 79/182 (43%), Positives = 116/182 (63%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIV--NDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHK 174
Y+NGHSDV+ GA + + + +++ + N +G P D +LV R LKTLA+R++ H+
Sbjct: 237 YLNGHSDVVGGAVVAPRDRTALLQRIQSMNNLLGTSQGPHDAFLVLRGLKTLALRVKAHE 296
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFL 351
+ +A +L HP+V V +PGL SHPQH + + Q G + SF + G + L
Sbjct: 297 AGARRVAAFLAGHPEVARVHYPGLASHPQHALARAQQRGFGAMLSFELRDGRPDRVDHVL 356
Query: 352 SSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
+L+ FTLAESLGG ESL P+ MTHAS+ E R + GITDS++RLS+G+E+ EDL+ D
Sbjct: 357 RTLRWFTLAESLGGVESLVAHPASMTHASMTPEARQRAGITDSVIRLSIGIEEPEDLLGD 416
Query: 532 LE 537
L+
Sbjct: 417 LD 418
>UniRef50_A5GJ98 Cluster: MetC/metB Cystathionine
beta-lyase/cystathioninegamma-synthase; n=21;
Cyanobacteria|Rep: MetC/metB Cystathionine
beta-lyase/cystathioninegamma-synthase - Synechococcus
sp. (strain WH7803)
Length = 393
Score = 155 bits (377), Expect = 5e-37
Identities = 75/179 (41%), Positives = 113/179 (63%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSD + GA + A++ F Q A+G++PSP DC+L+ R +KTL +R+ Q ++
Sbjct: 208 YINGHSDALGGAVCTDAPDWHARMVFAQKALGLMPSPFDCWLITRGIKTLPLRLRQQIEN 267
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ ++AN L +HP+V V +P HPQ + +Q G + + +++ +L
Sbjct: 268 AAVLANHLAEHPQVDWVRYPHRADHPQQAVALRQMQGGGAIVTIGLNTSREQAYAVCKAL 327
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ FT+AESLGG ESL P+ MTHA+V E +++LGITD L+RLSVG ED DLI DL+
Sbjct: 328 RWFTMAESLGGVESLICHPATMTHAAVSPEVKSKLGITDGLIRLSVGCEDVADLITDLD 386
>UniRef50_P00935 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=123;
Proteobacteria|Rep: Cystathionine gamma-synthase (EC
2.5.1.48) (CGS) (O-succinylhomoserine (thiol)-lyase) -
Escherichia coli (strain K12)
Length = 386
Score = 155 bits (377), Expect = 5e-37
Identities = 78/179 (43%), Positives = 107/179 (59%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSDV+ G I D + +L + N +G+ D YL+ R L+TL RME +++
Sbjct: 199 YLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRN 258
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ I +L P VK + HP LP + HEI +Q G + SF G + +FL L
Sbjct: 259 AQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGL 318
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+FTLAESLGG ESL + MTHA + E RA GI+++L+R+S G+ED EDLIADLE
Sbjct: 319 SLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
>UniRef50_A0LLP6 Cluster: Cystathionine gamma-synthase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Cystathionine
gamma-synthase - Syntrophobacter fumaroxidans (strain
DSM 10017 / MPOB)
Length = 400
Score = 154 bits (374), Expect = 1e-36
Identities = 76/179 (42%), Positives = 114/179 (63%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++NGHSDV+ G + + + A+++ + G P +L+ R LKTL +R+E+ + +
Sbjct: 215 FINGHSDVLGGMVVTRNEELHAQIKRMFTLFGGTIDPHQAWLILRGLKTLPLRVEKAQDN 274
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L HPKV + +PGLP HPQHE+ ++Q G + SF GL+ ++++
Sbjct: 275 AGRLARFLSGHPKVTWLRYPGLPDHPQHEVARRQMEGFGSMMSFGVKNGLEGGITLMNAV 334
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ TLA SLGG +SL E P+ MTHA++P E+R + GI D LVRLSVG ED EDL ADLE
Sbjct: 335 HLITLAVSLGGIDSLIEHPASMTHAAIPREERERAGIRDELVRLSVGCEDFEDLRADLE 393
>UniRef50_A3HJ37 Cluster: Cystathionine gamma-lyase; n=7;
Gammaproteobacteria|Rep: Cystathionine gamma-lyase -
Pseudomonas putida (strain GB-1)
Length = 400
Score = 153 bits (371), Expect = 2e-36
Identities = 74/179 (41%), Positives = 111/179 (62%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+ G + + + A+LR + A+G V P DCYL R LKTL +RME+ +
Sbjct: 213 YIGGHSDLTGGVVVAANDALLARLRRISMAIGAVQGPFDCYLALRGLKTLDVRMERQCAN 272
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A +L H +V+ V +PGL SHPQH + K+Q V + G N+ + +L
Sbjct: 273 ALQVARFLESHAQVEQVYYPGLESHPQHALCKRQMRSGGAVVAMKVKGDRAALNRLVEAL 332
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+IF LA+SLGG ES+ M+H S+ EQ+ +GI+++L+RLSVG+ED DL+ DL+
Sbjct: 333 QIFVLADSLGGVESMINHSWSMSHCSLSPEQKGVMGISENLLRLSVGIEDYRDLVEDLD 391
>UniRef50_O15564 Cluster: Methionine gamma-lyase; n=2; Trichomonas
vaginalis|Rep: Methionine gamma-lyase - Trichomonas
vaginalis
Length = 396
Score = 152 bits (369), Expect = 4e-36
Identities = 76/181 (41%), Positives = 113/181 (62%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRF--LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHK 174
Y+NGH+DV+ G I + ++R +++ G V SP D +L+ R L TL IRM+
Sbjct: 210 YINGHTDVVAGL-ICGKADLLQQIRMVGIKDITGSVISPHDAWLITRGLSTLNIRMKAES 268
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
++++ +A +L HP V+ V +PG H H+I KKQ + +F+ G + + K L
Sbjct: 269 ENAMKVAEYLKSHPAVEKVYYPGFEDHEGHDIAKKQMRMSGSMITFILKSGFEGAKKLLD 328
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+LK+ TLA SLGG ESL + P+ MTHA VP E+R GITD ++RLSVG+ED ++LIAD
Sbjct: 329 NLKLITLAVSLGGCESLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGIEDADELIADF 388
Query: 535 E 537
+
Sbjct: 389 K 389
>UniRef50_P55217 Cluster: Cystathionine gamma-synthase, chloroplast
precursor (EC 2.5.1.48) (CGS) (O-succinylhomoserine
(thiol)-lyase); n=30; Viridiplantae|Rep: Cystathionine
gamma-synthase, chloroplast precursor (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase) - Arabidopsis
thaliana (Mouse-ear cress)
Length = 563
Score = 151 bits (367), Expect = 7e-36
Identities = 74/178 (41%), Positives = 115/178 (64%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+ G I + +++R L + +G +P YL+ R +KTL +R++Q +
Sbjct: 380 YIGGHNDVLAGC-ICGSLKLVSEIRNLHHVLGGTLNPNAAYLIIRGMKTLHLRVQQQNST 438
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A L HPKV V +PGLPSHP+HE+ K+Q +G GV SF G ++ + KF+ SL
Sbjct: 439 AFRMAEILEAHPKVSHVYYPGLPSHPEHELAKRQMTGFGGVVSFEIDGDIETTIKFVDSL 498
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
KI +A S GG ES+ + P++M++ +P E+R + GI D+LVR S G+ED ED+ AD+
Sbjct: 499 KIPYIAPSFGGCESIVDQPAIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADI 556
>UniRef50_Q3JCU1 Cluster: Cystathionine gamma-synthase; n=1;
Nitrosococcus oceani ATCC 19707|Rep: Cystathionine
gamma-synthase - Nitrosococcus oceani (strain ATCC 19707
/ NCIMB 11848)
Length = 398
Score = 151 bits (366), Expect = 1e-35
Identities = 78/179 (43%), Positives = 116/179 (64%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGH D + G I + I A + +Q G V SP + +L R L+TL++RM +H ++
Sbjct: 215 YLNGHGDCVGGVVIGTEPAIQALRQEVQWHFGNVLSPFNAWLTLRGLQTLSLRMARHSET 274
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A +L +HPKV+ V +PGLPSHPQHE+ +KQ +G SG+ SF + + + L++L
Sbjct: 275 ALTVARFLEEHPKVQRVHYPGLPSHPQHELAQKQMAGFSGMISF-SLASREAGPRLLNNL 333
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ LA SLG +L E P+ M+HA+ E+ G+ +LVRLSVGLE+ DLIADLE
Sbjct: 334 QLCLLAVSLGHVATLIEHPASMSHAAYSEEECRAAGLDTALVRLSVGLEEATDLIADLE 392
>UniRef50_A3JID5 Cluster: Cystathionine beta-lyase; n=3;
Marinobacter|Rep: Cystathionine beta-lyase -
Marinobacter sp. ELB17
Length = 397
Score = 150 bits (363), Expect = 2e-35
Identities = 78/179 (43%), Positives = 112/179 (62%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+ GA ++ +A + + ++G + +P L++RSL+TL +R+ QH ++
Sbjct: 212 YLAGHSDLTAGA-FMSSAELAKPVAAWRKSLGQILAPEMAALLSRSLRTLHVRVRQHNEN 270
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ +A + KHPKV VL+PGLP P H++ K+Q G G+ S VGG K + L
Sbjct: 271 AMAVAIAMEKHPKVSRVLYPGLPDFPGHQLAKQQMHGFGGMLSIDVVGGGKAAECVEDHL 330
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++F LA SLGG ESL P +H + E RAQ GI+D L+RLSVGLED DLIADLE
Sbjct: 331 QVFLLATSLGGVESLVSQPIATSHYRLTPEDRAQRGISDGLLRLSVGLEDAGDLIADLE 389
>UniRef50_Q7UQA0 Cluster: Cystathionine gamma-synthase; n=4;
Bacteria|Rep: Cystathionine gamma-synthase -
Rhodopirellula baltica
Length = 434
Score = 149 bits (361), Expect = 4e-35
Identities = 74/180 (41%), Positives = 113/180 (62%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D++ G I + +R L+ +G V SP YL+ R LKT ++RM++H ++
Sbjct: 250 YLGGHNDLLAGV-ISGRKELLDPIRALRGCLGSVTSPHSMYLLERGLKTFSLRMQRHNEN 308
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+A +L +HPK+ V +PGLPSHP H I K+Q G+ G+ +F V K +++ + +
Sbjct: 309 GQAVAEFLHQHPKIDRVYYPGLPSHPTHAIAKEQMLGYGGLITFTVKDADWKTTSRVVDA 368
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
KI +A SLGG ESL E P VM++ E+RA GI D+++R S G+ED+ DLIADL+
Sbjct: 369 AKIARIAPSLGGTESLIEQPLVMSYFHYSPEERACFGIADNMIRFSCGIEDSADLIADLD 428
>UniRef50_P13254 Cluster: Methionine gamma-lyase; n=33; cellular
organisms|Rep: Methionine gamma-lyase - Pseudomonas
putida
Length = 398
Score = 149 bits (360), Expect = 5e-35
Identities = 71/180 (39%), Positives = 121/180 (67%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVI-AAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y++GH D+ G + + ++ +L+ L++ G V SP D L+ R +KTL +RM++H
Sbjct: 212 YLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAVLSPHDAALLMRGIKTLNLRMDRHCA 271
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++ ++A +L + P+V+ + +PGL S PQ+ + ++Q S G+ +F GG+ +F+++
Sbjct: 272 NAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMNA 331
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++F+ A SLG ESLA+ P+ MTH+S E+RA GI++ LVRLSVGLED +DL+AD++
Sbjct: 332 LQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQ 391
>UniRef50_Q26GX1 Cluster: Cys/Met metabolism PLP-dependent enzyme;
n=2; Flavobacteria|Rep: Cys/Met metabolism PLP-dependent
enzyme - Flavobacteria bacterium BBFL7
Length = 423
Score = 148 bits (359), Expect = 7e-35
Identities = 79/181 (43%), Positives = 120/181 (66%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+I GA + N I +++ L+ +G + SP +++ RSL+TL IRMEQ +++
Sbjct: 230 YIGGHSDLIAGAVLGN-AEIMHRVKVLRTFLGNMASPHTGWMLMRSLETLKIRMEQQQRN 288
Query: 181 SLIIANWLLKHPKVKDVLHPGL--PSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
++ +A++L H K+ + + GL P P ++I K+Q G + SF GG KE+ KFL+
Sbjct: 289 AIEVAHFLKDHEKITKLNYLGLIQPDAPDYKIYKRQYDGPGAMISFEIKGGEKEAFKFLN 348
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
SL++ LA SLGG ESLAE P MTHA V +G+T SLVRLS+G+E+++DLIAD+
Sbjct: 349 SLRLIRLAVSLGGTESLAEHPRSMTHAGVDENHAESIGVTHSLVRLSIGVENSDDLIADV 408
Query: 535 E 537
+
Sbjct: 409 K 409
>UniRef50_A3VS82 Cluster: Cystathionine gamma-synthase; n=1;
Parvularcula bermudensis HTCC2503|Rep: Cystathionine
gamma-synthase - Parvularcula bermudensis HTCC2503
Length = 392
Score = 148 bits (359), Expect = 7e-35
Identities = 74/178 (41%), Positives = 113/178 (63%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGH+D+I GA I D +A++L + NA G+ + D Y+ R +TL++R+ + + +
Sbjct: 207 YINGHTDIIGGALITKDPELASELAWWANATGVTGASFDSYMTLRGARTLSLRVHRAQAT 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA+ L+ HP V + +PGL SHPQH + ++Q G + SF + + FL+ L
Sbjct: 267 AGQIADALVGHPAVVGLNYPGLGSHPQHALIRRQQKGPGAMMSFDLAPSI-DPRAFLAGL 325
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
++FT A SLGG+ESL +P++MTHA + RA G+ D LVRLS+GLE EDL+ DL
Sbjct: 326 EVFTPAASLGGFESLVCIPAIMTHAGMTPAARAAAGLGDRLVRLSIGLEHPEDLLNDL 383
>UniRef50_Q8KNG3 Cluster: CalE6; n=2; Micromonosporaceae|Rep: CalE6
- Micromonospora echinospora (Micromonospora purpurea)
Length = 381
Score = 147 bits (357), Expect = 1e-34
Identities = 74/175 (42%), Positives = 105/175 (60%)
Frame = +1
Query: 10 GHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLI 189
GH+DV+ GA + D + A +R + G VP +DC+LV R L TL++R+ + ++ +
Sbjct: 201 GHADVLGGALVYRDADLHAAVRAYRTTAGNVPGALDCFLVRRGLHTLSLRVHRQVATARV 260
Query: 190 IANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIF 369
+ L P V V +PGLP HPQH + K Q S + SF ++GG E + L +F
Sbjct: 261 LVERLRASPVVGAVHYPGLPEHPQHAVVKAQMSAPGAIVSFDYLGGPAE--RLLDRFTLF 318
Query: 370 TLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
T SLGG SL E P++MTH + AE RA+ GI +SL+RLSVG+ED +DL DL
Sbjct: 319 TCGVSLGGVHSLVECPALMTHRPLSAEARARRGIGESLIRLSVGIEDPQDLAEDL 373
>UniRef50_Q5MQ31 Cluster: L-methionine-gamma-lyase; n=3;
Micrococcineae|Rep: L-methionine-gamma-lyase -
Brevibacterium linens
Length = 425
Score = 147 bits (357), Expect = 1e-34
Identities = 75/186 (40%), Positives = 113/186 (60%), Gaps = 7/186 (3%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGV-------IAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIR 159
++NGHSDVI GA + DG + +L ++G+ +P D +L R +KTL +R
Sbjct: 203 FINGHSDVIGGAVLAGDGSTCPRAAKVVERLESYLASVGLGIAPFDAWLTRRGIKTLPVR 262
Query: 160 MEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES 339
M +H +++ +A WL P++ +V +PGLPSHP HE+ KKQ SG GV SF +
Sbjct: 263 MAKHCENAQAVAQWLESRPEIAEVYYPGLPSHPGHEVAKKQMSGFGGVVSF-RTDTEARA 321
Query: 340 NKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTED 519
+ S K+ TLAESLGG ESL + P+ MTH +V +L ++ + +RLS+G+ED D
Sbjct: 322 LSLVKSTKLITLAESLGGVESLIDHPATMTHLAV---ADCELSVSPTFIRLSLGIEDIAD 378
Query: 520 LIADLE 537
++ADL+
Sbjct: 379 ILADLD 384
>UniRef50_Q86D27 Cluster: Methionine gamma-lyase 2; n=3; Entamoeba
histolytica|Rep: Methionine gamma-lyase 2 - Entamoeba
histolytica
Length = 392
Score = 147 bits (357), Expect = 1e-34
Identities = 73/179 (40%), Positives = 110/179 (61%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGH DV+ G + + K++ + G + +PMD +L R +KTL +RM+ H ++
Sbjct: 209 YINGHGDVVGGVVTTKNPELLQKIKAFRKDTGSLMAPMDAFLCIRGVKTLPMRMKVHMEN 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
L +A +L +HPK+K V HPGL S P H+I +Q G FSF + + + K + +
Sbjct: 269 GLKVAKFLEQHPKIKQVNHPGLESFPGHKIAMEQMKGFGSTFSF-EMKSFEAAKKLMEHV 327
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ LA SLG ++L E P+ MTHA+VP Q G+T LVR+SVGLE+ +D+IADL+
Sbjct: 328 KLCGLAVSLGTLDTLIEHPASMTHAAVPEHLLKQQGLTRELVRISVGLENPDDIIADLK 386
>UniRef50_Q12L75 Cluster: Methionine gamma-lyase; n=1; Shewanella
denitrificans OS217|Rep: Methionine gamma-lyase -
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 /
DSM 15013)
Length = 390
Score = 147 bits (356), Expect = 2e-34
Identities = 78/180 (43%), Positives = 112/180 (62%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRF-LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGH DVI G N + KLR+ + G V SP D +L+ R LKTL +R+ +H
Sbjct: 208 YLNGHGDVIAGIVCGNSEHMH-KLRYEILKDFGGVMSPHDAWLILRGLKTLDVRLARHCD 266
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++ I+AN+L++H V +PGL +H H KQ GV +F G +++ F++
Sbjct: 267 NAEILANYLVEHKAFSQVFYPGLSTHQGHAFIGKQMKRAGGVIAFELKGDKQDAINFVNR 326
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LK+FT+A SLG ESL + P+ MTH+ E R + GITD+L+R+SVGLED +DLIAD+E
Sbjct: 327 LKLFTIAVSLGDAESLIQHPASMTHSPYTLEARMEAGITDNLLRISVGLEDVQDLIADIE 386
>UniRef50_UPI00015BB00D Cluster: cystathionine gamma-synthase; n=1;
Ignicoccus hospitalis KIN4/I|Rep: cystathionine
gamma-synthase - Ignicoccus hospitalis KIN4/I
Length = 387
Score = 146 bits (354), Expect = 3e-34
Identities = 74/179 (41%), Positives = 107/179 (59%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+ G ND A L+ ++ +G +P P Y + R LKTL +R+ ++
Sbjct: 203 YLAGHNDVLGGIFATNDKKFALNLKNVRRMLGGIPDPQQAYFIIRGLKTLHVRVAYQNEA 262
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L IA +L HPKV+ V +P L HP + + K+ G GV SF G ++ K + +
Sbjct: 263 ALRIAKFLRDHPKVERVYYPCLEEHPSYPVAKRLLKGCGGVVSFEVRGNGFDAIKVMKKV 322
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ SLGG ES+ P+ MTH +VP E R +LGI D+L+RLSVGLE+ EDL ADL+
Sbjct: 323 KVVQRTASLGGVESIITHPATMTHHTVPPEVRKELGIKDNLLRLSVGLENVEDLEADLD 381
>UniRef50_Q1J8Q9 Cluster: Cystathionine beta-lyase; n=14;
Bacilli|Rep: Cystathionine beta-lyase - Streptococcus
pyogenes serotype M4 (strain MGAS10750)
Length = 463
Score = 146 bits (353), Expect = 4e-34
Identities = 73/179 (40%), Positives = 108/179 (60%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++NGHSDV+ G A N+ I +L+ Q G + D +L+ R +KT+ IRMEQ K+
Sbjct: 281 FINGHSDVVAGLAATNNEAIYNQLKLFQKNFGAIVGVEDAWLILRGMKTMGIRMEQAVKN 340
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +AN+L KHPKV V +PGL SHP H+ +Q V SF + +E F +
Sbjct: 341 AQQLANYLAKHPKVLKVHYPGLDSHPNHDTHLQQAKNGGAVLSF-ELASKEELMTFTHRI 399
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ LA SLGG ES+ P+ M+HA + ++ R + G+ D L+RLS G+E+ EDL+AD E
Sbjct: 400 QLPILAVSLGGVESILSHPATMSHACLSSQARLEQGVVDGLLRLSCGVENIEDLLADFE 458
>UniRef50_Q0ALD7 Cluster: Cystathionine gamma-synthase; n=2;
Hyphomonadaceae|Rep: Cystathionine gamma-synthase -
Maricaulis maris (strain MCS10)
Length = 382
Score = 145 bits (352), Expect = 5e-34
Identities = 74/178 (41%), Positives = 106/178 (59%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
+NGHSD++ G D A+L + N +G+ + D YL R L+TL +R +S+
Sbjct: 199 LNGHSDMVGGVVCCADPERVAELGWWANCVGVGAAAFDSYLALRGLRTLPLRARAQCESA 258
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
+A WL P+V V +PGL SHP H + +Q G + S + +S+L+
Sbjct: 259 QEVARWLDADPRVARVDYPGLTSHPGHALAARQQDGFGQLISLELAKDAPDPRAVVSALE 318
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
IFTLA+SLGG ESL +P++MTHAS+ E RA+ G+ DSL+RLS+GLE D IADL+
Sbjct: 319 IFTLAQSLGGVESLCCIPALMTHASMSPEARAEAGVADSLIRLSIGLESAADQIADLD 376
>UniRef50_Q9YA71 Cluster: Cystathionine gamma-synthase; n=1;
Aeropyrum pernix|Rep: Cystathionine gamma-synthase -
Aeropyrum pernix
Length = 389
Score = 144 bits (350), Expect = 9e-34
Identities = 71/179 (39%), Positives = 110/179 (61%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+ G+ L ++ +G + P+D YL R +KTL R E ++
Sbjct: 204 YIAGHNDVVGGSLSGRVEEDLEPLWNMRKILGTIMQPIDAYLAWRGMKTLKARFEAQSRA 263
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSG-HSGVFSFVHVGGLKESNKFLSS 357
++ +A WL H KVK V +PGL SHP HE+ +++ +G + V SF GG +E K LS
Sbjct: 264 AVEVAEWLESHRKVKKVYYPGLSSHPDHELARRELNGLYGAVVSFEIEGGREEVFKLLSR 323
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
LK+ T + S GG E++ P++ +H+++ +R++LG+TD L+RLSVGLED D+I DL
Sbjct: 324 LKLVTPSPSFGGVETIISYPAISSHSNLDPLERSELGVTDGLLRLSVGLEDVSDIIDDL 382
>UniRef50_Q9KEQ0 Cluster: Methionine gamma lyase; n=13;
Bacillaceae|Rep: Methionine gamma lyase - Bacillus
halodurans
Length = 393
Score = 143 bits (347), Expect = 2e-33
Identities = 76/179 (42%), Positives = 108/179 (60%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH DV+ G I + I + Q MG V SP D +L+ R LKTLA+RM++H ++
Sbjct: 209 YIGGHGDVVAGVLIGDKETIQLIRKTTQKDMGGVISPFDAWLLLRGLKTLAVRMDRHCEN 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A L +HPKV VL+PG HP H I KQ G+ SF G + K ++ L
Sbjct: 269 AEKLAEKLKEHPKVSTVLYPGDFEHPDHSIVAKQMKKGGGLLSFEIKGTEADIAKVVNQL 328
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ +A SLG E+L + P+ MTHA VP ++R Q+GI+ L+R+S GLE +D+ ADLE
Sbjct: 329 KLIRIAVSLGDAETLIQHPATMTHAVVPEKRRTQMGISKKLLRMSAGLEAWQDVWADLE 387
>UniRef50_A1ID11 Cluster: Cystathionine gamma-synthase; n=1;
Candidatus Desulfococcus oleovorans Hxd3|Rep:
Cystathionine gamma-synthase - Candidatus Desulfococcus
oleovorans Hxd3
Length = 392
Score = 143 bits (346), Expect = 3e-33
Identities = 70/179 (39%), Positives = 107/179 (59%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D++ G + + ++ FL+ G++ P YL+ R LKT +RME+ ++
Sbjct: 211 YLAGHNDLLSGVVLGSKKLVEPVREFLKITGGVI-DPNSAYLLIRGLKTFGLRMERLNEN 269
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
I+A L +HPK+ V +PGLPSHP H++ K Q G V +F G + FLS L
Sbjct: 270 GQIVAEGLERHPKISRVYYPGLPSHPHHDVAKAQMKGFGAVVTFEVEGDCEYVLNFLSRL 329
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
KI + SLGG ESL P+ +++ ++R LGI D L+RL+VG+E+ ED+IAD+E
Sbjct: 330 KIINIGPSLGGVESLITHPATISYYDKTRKERLALGIKDGLIRLAVGVENAEDIIADIE 388
>UniRef50_A2BL10 Cluster: Methionine gamma-lyase; n=1; Hyperthermus
butylicus DSM 5456|Rep: Methionine gamma-lyase -
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Length = 397
Score = 141 bits (341), Expect = 1e-32
Identities = 76/181 (41%), Positives = 112/181 (61%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YM GH+DV+ G+ +++ +L + MG P +LV R LKTL IR+++H ++
Sbjct: 211 YMAGHNDVMGGSVTGPASIVSDRLWEWRKIMGTTMDPEQAFLVARGLKTLEIRVKRHCEN 270
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSG-HSGVFSFVHVGGLKESNKFLS 354
+L IA +L +HPK+++V +PGLP +P H + K+ SG + GV SF GG E K +
Sbjct: 271 ALKIAEFLAEHPKIREVYYPGLPGNPSHSVAKRLFPSGMYGGVVSFRVRGGRNEVLKLMR 330
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L + + SLG ESL P +H+S+ E+R LGIT+ LVRLSVGLE+ ED+I DL
Sbjct: 331 RLTLVKPSPSLGAPESLLAYPVESSHSSLSPEERKALGITEDLVRLSVGLENYEDIIEDL 390
Query: 535 E 537
+
Sbjct: 391 D 391
>UniRef50_Q8R9N2 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=4; Bacteria|Rep: Cystathionine
beta-lyases/cystathionine gamma-synthases -
Thermoanaerobacter tengcongensis
Length = 393
Score = 140 bits (338), Expect = 2e-32
Identities = 73/180 (40%), Positives = 106/180 (58%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSDVI G N I R + N G + SP D +L R KTL +RM +H K+
Sbjct: 209 YINGHSDVIGGLIAGNKEFIFRTRRIVHNFGGSM-SPFDAWLTLRGAKTLFLRMREHCKN 267
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGH-SGVFSFVHVGGLKESNKFLSS 357
++ +A +L HPKVK V +PGLPSHP + I KK G+ SF GG + N+F+
Sbjct: 268 AMRLAEFLESHPKVKKVFYPGLPSHPDYSIAKKLFKDEFGGMLSFEIDGGEQSVNRFMQE 327
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LK+ A SL G +++ P +H ++ E+ LGI++ L+R+SVG+E+ ED+I D +
Sbjct: 328 LKLIKFAPSLAGVQTMITHPKSTSHRALSKEELKALGISEGLIRVSVGIEEIEDVIRDFK 387
>UniRef50_A6X770 Cluster: Cystathionine gamma-synthase; n=1;
Ochrobactrum anthropi ATCC 49188|Rep: Cystathionine
gamma-synthase - Ochrobactrum anthropi (strain ATCC
49188 / DSM 6882 / NCTC 12168)
Length = 398
Score = 138 bits (335), Expect = 6e-32
Identities = 77/183 (42%), Positives = 110/183 (60%), Gaps = 6/183 (3%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGV---IAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHK 174
+NGHSD++ G V+ +A ++ +LQNA+G V SP DC L++RSLKTL IR +
Sbjct: 208 LNGHSDLLGGVVAVSANAPAKLAERVGYLQNALGSVMSPTDCALLHRSLKTLEIRSIRQS 267
Query: 175 KSSLIIANWLLKHPK---VKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNK 345
+++L +A L K + + V++PGL SHPQH++ +Q V S G L +
Sbjct: 268 ETALKLATSLEKRAEELGLTKVVYPGLASHPQHKLAAEQMINFGCVISIEVAGDLTRVER 327
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
L+S + F A SLG ESL + P +THA VP +Q+ LGI L+R+S+GLED EDL
Sbjct: 328 ILTSTRYFHFAVSLGSVESLIQHPYSLTHAVVPEDQKNHLGIGAQLIRISIGLEDPEDLE 387
Query: 526 ADL 534
DL
Sbjct: 388 TDL 390
>UniRef50_A6LPZ9 Cluster: Cystathionine gamma-synthase; n=4;
Bacteria|Rep: Cystathionine gamma-synthase - Clostridium
beijerinckii NCIMB 8052
Length = 382
Score = 138 bits (333), Expect = 1e-31
Identities = 71/179 (39%), Positives = 109/179 (60%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GH D++ G + ND I KLR + + G SP D +L+ R +KTL IR+E+ +++
Sbjct: 200 FLGGHHDLLAGFIVANDEEILEKLRRIHMSTGATLSPFDSWLILRGIKTLHIRLERSQEN 259
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L IA +L +PKV+ V + GL +E+ KKQ++G SF V + K L +
Sbjct: 260 TLKIAKFLEGNPKVEKVYYVGLEGFEGYELNKKQSTGFGATLSF-RVKEKELVAKILERV 318
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ AESLGG E+L P TH+ +P E + +LG+ + L+RLSVG+E+ EDL+ DLE
Sbjct: 319 KVIRFAESLGGVETLITYPFTQTHSEIPEEIKQRLGVDEYLLRLSVGIENVEDLLNDLE 377
>UniRef50_A5V1Q1 Cluster: Cystathionine gamma-synthase; n=2;
Roseiflexus|Rep: Cystathionine gamma-synthase -
Roseiflexus sp. RS-1
Length = 409
Score = 138 bits (333), Expect = 1e-31
Identities = 70/180 (38%), Positives = 104/180 (57%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH DV G + G++ LR +G P + Y + R LKTLA+R+ Q +S
Sbjct: 220 YLGGHGDVAGGVVVARTGLVRDTLRRQARLLGASLGPFEAYQILRGLKTLALRVRQQCRS 279
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSG-VFSF-VHVGGLKESNKFLS 354
+ IA WL HP V V +PGL SHPQH + + G G + +F + + ++F
Sbjct: 280 AAEIATWLTTHPAVATVHYPGLASHPQHTLATEMFGGLFGALVTFELRAANREALHRFFD 339
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L++ A +LG +LA PS+ +H + EQRA+ GI+D +VRLSVG+E+T D+IADL
Sbjct: 340 ALRLILPATTLGDVYTLASAPSIASHRELTPEQRAERGISDGMVRLSVGIEETADIIADL 399
>UniRef50_Q98K64 Cluster: Methionine gamma-lyase; n=13;
Bacteria|Rep: Methionine gamma-lyase - Rhizobium loti
(Mesorhizobium loti)
Length = 427
Score = 137 bits (331), Expect = 2e-31
Identities = 76/180 (42%), Positives = 114/180 (63%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+I GAA+ + V ++ L+ A+G P C+++ RSL+TL+IRME+ +
Sbjct: 242 YVGGHSDLIAGAAMGSKAV-TKPIKALRGAIGTQLDPHSCWMLGRSLETLSIRMERANDN 300
Query: 181 SLIIANWLLKHPKVKDVLH-PGLPSH-PQHEITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
+ ++A +L H KV+ V + P L P +Q SG FSF GG K + FL+
Sbjct: 301 ARLVAEFLRDHAKVEKVHYLPFLGEDTPAGRAYVRQCSGAGSTFSFDIKGGEKAAFAFLN 360
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L+IF LA SLGG ESLA P+ MTH+ +P + R ++G+ ++ VRLS+G+E +DLIADL
Sbjct: 361 ALQIFKLAVSLGGTESLASHPAAMTHSGIPFDVRQRIGVLETTVRLSIGVEHPDDLIADL 420
>UniRef50_A6GHC8 Cluster: Cystathionine gamma-synthase; n=1;
Plesiocystis pacifica SIR-1|Rep: Cystathionine
gamma-synthase - Plesiocystis pacifica SIR-1
Length = 369
Score = 137 bits (331), Expect = 2e-31
Identities = 75/179 (41%), Positives = 108/179 (60%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D++ G I G++ A +R +G V P + YL++R LKTLA+R+E+H S
Sbjct: 187 YLGGHNDLLGGVVIGKSGLVDA-IREQVGTLGAVCDPHNAYLLSRGLKTLALRVERHNHS 245
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A L HPKV V +P L SH + ++ G GV SF V GL+ + + +L
Sbjct: 246 ALALARVLEAHPKVAKVWYPLLESHQDYGHARRLLRGGGGVISF-EVEGLEAGTRLVDAL 304
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ LA SLGG ESL E P++M+ E RA LGI + L+R +VG+ED DL ADLE
Sbjct: 305 RVPKLAPSLGGVESLVEQPALMSFYDQGPEGRAALGIREGLIRYAVGIEDLADLRADLE 363
>UniRef50_A6YH84 Cluster: Cystathionine gamma-synthase; n=2;
Lactobacillus casei|Rep: Cystathionine gamma-synthase -
Lactobacillus casei
Length = 378
Score = 136 bits (330), Expect = 2e-31
Identities = 69/178 (38%), Positives = 112/178 (62%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH D+I G + I+ K+ FLQN +G + +P+DC LV R + TLA+R+++ +
Sbjct: 197 YIGGHGDLIAGLVVSASPEISEKIGFLQNTIGAILAPLDCSLVCRGIATLAVRLDRETSN 256
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L +HP V V +PGL S P + + +++T+G SG+ S + + +S KF++S
Sbjct: 257 AQAVAEFLEQHPDVAHVYYPGLKSDPGYALAQQETTGASGLLS-IKLADNIDSIKFVNST 315
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+F A+SLG SL +LP +P E+R+ G+T VR+++GLED +DLI DL
Sbjct: 316 KVFDFADSLGTVSSLVKLP----WFKLPEEKRSTSGLTPQHVRIAIGLEDQQDLIDDL 369
>UniRef50_A1HQW4 Cluster: Cystathionine gamma-synthase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Cystathionine
gamma-synthase - Thermosinus carboxydivorans Nor1
Length = 392
Score = 136 bits (328), Expect = 4e-31
Identities = 72/180 (40%), Positives = 104/180 (57%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSD + G IV D AK + + G SP D +L R LKTLA+RM +H ++
Sbjct: 208 YLNGHSDAMAGV-IVADSDFIAKAKNVGTTYGATLSPFDAWLTLRGLKTLALRMHRHAEN 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKK-QTSGHSGVFSFVHVGGLKESNKFLSS 357
+L +A +L HPKV V +PGL S H KK +G G+ SF GGL + + S
Sbjct: 267 ALALAKYLQVHPKVTGVNYPGLESTKTHGCAKKLLQNGFGGMLSFTVQGGLAGARTVIDS 326
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++ L SL G + P+ +H ++PA +R G++D L+R+SVGLE+ D+IAD +
Sbjct: 327 LEMVKLVPSLAGPATTTSHPAKTSHRAMPAAEREACGVSDGLIRVSVGLEEAADIIADFD 386
>UniRef50_Q9K024 Cluster: Cystathionine gamma-synthase; n=4;
Neisseria|Rep: Cystathionine gamma-synthase - Neisseria
meningitidis serogroup B
Length = 385
Score = 135 bits (327), Expect = 5e-31
Identities = 69/180 (38%), Positives = 105/180 (58%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+MG + +A L + G V P+DC+LV R +KTLA+RM H ++
Sbjct: 198 YLCGHSDVLMGIVVAKTKELAQPLHDMMVHTGAVAGPLDCWLVLRGIKTLALRMNAHCQN 257
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSGHSGVFSFVHVGGLKE-SNKFLS 354
+L IA L HP ++ V HPGLPSH +E+ K Q G GV + +E +N +
Sbjct: 258 ALEIARRLEAHPAIEKVFHPGLPSHEHYELAKTQMPKGIGGVVTVYLKNDTREAANSVIK 317
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
++K+ +A SLGG ESL +H+ VP + + ++GI L+R S+G+ED +D+ D+
Sbjct: 318 NMKLVKMASSLGGVESLVNHCYSQSHSGVPHDVKMEMGIKVGLLRFSIGIEDADDIWNDI 377
>UniRef50_Q1IQ68 Cluster: Cystathionine gamma-synthase; n=1;
Acidobacteria bacterium Ellin345|Rep: Cystathionine
gamma-synthase - Acidobacteria bacterium (strain
Ellin345)
Length = 400
Score = 134 bits (325), Expect = 9e-31
Identities = 69/179 (38%), Positives = 105/179 (58%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GH+ + G+ +D + + R ++ +G +P + +L + +KTL R++ H ++
Sbjct: 202 YIDGHNATLGGSLATHDEKLLERFRLIRKTIGTTQAPFEAWLTLQGMKTLPARLKLHCEN 261
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IIA WL HP V V PGL S Q + KQ + G+ +F G + + L+ +
Sbjct: 262 AQIIAEWLEAHPAVARVYFPGLDSCEQKALADKQQNAPGGMIAFELKAGFDATIRALNHV 321
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ + AESLGG E+L PS THA V + R LGI+D LVRLSVGLE +D+IADLE
Sbjct: 322 KLCSRAESLGGLETLITHPSSTTHADVEPQVRRALGISDGLVRLSVGLEAAQDIIADLE 380
>UniRef50_Q67QQ8 Cluster: Cystathionine gamma-lyase; n=1;
Symbiobacterium thermophilum|Rep: Cystathionine
gamma-lyase - Symbiobacterium thermophilum
Length = 395
Score = 134 bits (324), Expect = 1e-30
Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSDV+ GA + I Q +G V P + +L+ R L+TL +R+ QH++S
Sbjct: 214 YFGGHSDVLAGAVLGPAERIRRIGDAEQPLLGGVVGPFEAWLIGRGLRTLPLRLRQHQQS 273
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+ +A +L HP+V V +PG PSHPQH + +Q G SG+ SF + G LK+ ++F+ +
Sbjct: 274 AGRVAEFLAGHPRVARVHYPGHPSHPQHGLALRQMRGASGLLSFELDTGDLKQVSRFVDA 333
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++F L S GGYESL LP + P EQ G LVR+ VGLED +DL+ DL+
Sbjct: 334 LRLFRLGVSWGGYESLVWLPVIGAMHRAPEEQWPNPG----LVRIHVGLEDVDDLLEDLD 389
>UniRef50_Q5GSE3 Cluster: Cystathionine beta-lyase; n=5;
Wolbachia|Rep: Cystathionine beta-lyase - Wolbachia sp.
subsp. Brugia malayi (strain TRS)
Length = 413
Score = 134 bits (324), Expect = 1e-30
Identities = 75/180 (41%), Positives = 104/180 (57%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD++MGA I V +N G+ P DCYL +R L+TL RM +H+ +
Sbjct: 213 YIAGHSDLLMGAIIAEGEVFKLLYEICKN-YGVTVQPYDCYLAHRGLRTLGTRMRKHQST 271
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV--HVGGLKESNKFLS 354
++ +A WL KH K+K VL+P LPSHPQHE+ K G SGVFS V +E + +
Sbjct: 272 AMKVAKWLEKHSKIKKVLYPALPSHPQHELWKSYFKGASGVFSIVLDREYSCEELSCMVD 331
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+KIF++ S GG +SL LP + SV + + S +R+ GLED EDLI+DL
Sbjct: 332 HMKIFSIGASWGGCDSLI-LP--IDRKSVSRSVMSS-DYSGSFIRIFCGLEDPEDLISDL 387
>UniRef50_Q7X1G1 Cluster: Lfe147p1; n=2; Leptospirillum|Rep:
Lfe147p1 - Leptospirillum ferrooxidans
Length = 321
Score = 134 bits (324), Expect = 1e-30
Identities = 68/180 (37%), Positives = 108/180 (60%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNA-MGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+ GH D ++G + + +L F + + +G SP + +L+ R +KTL +RM+ H +
Sbjct: 139 YLGGHGD-LLGGTVTGKASLIDRLSFEEGSYLGATLSPFNAWLLLRGMKTLPLRMDAHCR 197
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++++A +L HP VK V +PGL P H+I Q G G+ SF +G + + + S
Sbjct: 198 GAMMVAEFLSGHPGVKSVHYPGLSKDPGHKIASSQMKGFGGMLSF-SLGDDQRARRVASG 256
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++F +A SLG ESL E P+ ++H + AE+R LGI +R+SVGLED EDL+ DL+
Sbjct: 257 LELFKIAVSLGDPESLIEHPASLSHRQMTAEERMTLGIDPGFLRVSVGLEDPEDLVMDLK 316
>UniRef50_Q1GVW8 Cluster: Cystathionine gamma-lyase; n=15;
Bacteria|Rep: Cystathionine gamma-lyase - Sphingopyxis
alaskensis (Sphingomonas alaskensis)
Length = 430
Score = 134 bits (324), Expect = 1e-30
Identities = 73/178 (41%), Positives = 111/178 (62%), Gaps = 1/178 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSD++ G + D + +R ++N +G + P +++ RSL+TL +RM + ++
Sbjct: 246 YAGGHSDLVAGG-VSGDQRLLDIIRPMRNTIGTICDPNTAWMLLRSLETLELRMRRAGEN 304
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHP-QHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
+L + +L HPKV+ + + G S Q +I + +G FS GG ES +FL +
Sbjct: 305 ALKVCTFLRDHPKVEGLGYLGFISDARQKDIFDRHCTGAGSTFSLFIKGGEAESFRFLDA 364
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
L+I LA SLGG E+LA P+ MTH SVP E++ LGITD+LVR+S+G+ED +DLIAD
Sbjct: 365 LQIAKLAVSLGGTETLASHPAAMTHLSVPDERKKALGITDNLVRVSIGIEDPDDLIAD 422
>UniRef50_A6W1L9 Cluster: Cystathionine gamma-synthase; n=10;
Bacteria|Rep: Cystathionine gamma-synthase - Marinomonas
sp. MWYL1
Length = 405
Score = 134 bits (324), Expect = 1e-30
Identities = 71/179 (39%), Positives = 102/179 (56%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++GH+D MG + + AK+R + G P YL+ R +KTLA+R+ Q + S
Sbjct: 217 FLSGHADA-MGGLVCGSEELMAKVRHYREINGASLDPFSAYLIIRGMKTLALRIRQQQSS 275
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +LL V+ V +PGLPSHP H I +Q G + SFV VGG+ L L
Sbjct: 276 AKAIAEYLLTETLVEAVNYPGLPSHPNHAIACEQMRGFGAIVSFVLVGGMDTVKILLPQL 335
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ A +LG E++ +H E+R LGI++ LVR+SVG+EDTEDLIADL+
Sbjct: 336 QYAHCAGNLGAVETIYGPARTTSHVENTLEERLALGISEGLVRISVGIEDTEDLIADLQ 394
>UniRef50_Q97W69 Cluster: O-succinylhomoserine (Thiol)-lyase; n=5;
Archaea|Rep: O-succinylhomoserine (Thiol)-lyase -
Sulfolobus solfataricus
Length = 376
Score = 133 bits (321), Expect = 3e-30
Identities = 72/179 (40%), Positives = 106/179 (59%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GH+DVI G A + + ++ +G P YL R +KTL IRM+ ++
Sbjct: 192 FLAGHNDVIAGLAAGYSKYLNV-IDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRN 250
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L HPKV V +PGL SH ++I +K G GV SF GG + + K + SL
Sbjct: 251 AEQIAEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKGFGGVLSFEVNGGQESALKVMKSL 310
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ A++LGG S+ P+ M+H ++ E+R +GITDSL+RLSVG+ED DLI DL+
Sbjct: 311 KLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLD 369
>UniRef50_Q5WAZ1 Cluster: Methionine gamma-lyase; n=1; Bacillus
clausii KSM-K16|Rep: Methionine gamma-lyase - Bacillus
clausii (strain KSM-K16)
Length = 402
Score = 132 bits (319), Expect = 5e-30
Identities = 67/178 (37%), Positives = 107/178 (60%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G + +I K+R + G P +L+ R ++TL +RME+H ++
Sbjct: 219 YLGGHSDVVAGVCAGSTELID-KVRHKYSFHGPHLDPFGAWLLCRGIRTLGLRMEKHNEN 277
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A +L HPK++ V +P SHPQ+++ KQ +G G+ F G+ +S++
Sbjct: 278 ALKLAQFLETHPKIRQVFYPFSESHPQYKLATKQMTGGGGMICFELKDGMDGGLGLISNV 337
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+ +A SLGGY S P+ MTH +P E+R + GITD ++R SVG+E+ ED+ DL
Sbjct: 338 KLNKMAVSLGGYASTITHPASMTHNLLPREEREKGGITDGMIRFSVGIEEYEDIRDDL 395
>UniRef50_Q1IQ69 Cluster: Cystathionine beta-lyase; n=6;
Bacteria|Rep: Cystathionine beta-lyase - Acidobacteria
bacterium (strain Ellin345)
Length = 407
Score = 131 bits (317), Expect = 9e-30
Identities = 73/181 (40%), Positives = 109/181 (60%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV++GA + D I KL +G PSP DC L R +KTL +R+ Q S
Sbjct: 228 YVAGHSDVLLGAITIRDRAIYEKLGNTYQVLGCAPSPDDCQLALRGMKTLGVRLAQIGSS 287
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGG--LKESNKFLS 354
+L +A WL P+++ VLHP LPS P HE ++ +G +G+FS V G ++ F++
Sbjct: 288 ALRVAQWLAARPEIETVLHPALPSCPGHEFWERDFTGSAGLFSIVFKSGPTKQQVQAFVN 347
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L++F + S GG SLA + ++H A+ R++ G +VRL +GLE+ E+LIADL
Sbjct: 348 ALELFEIGYSWGGVASLA-VNYDLSH----AKGRSEYG--HRIVRLYIGLEEPEELIADL 400
Query: 535 E 537
E
Sbjct: 401 E 401
>UniRef50_Q97CC7 Cluster: Cystathionine beta lyase /
O-succinylhomoserine lyase; n=5; Thermoplasmatales|Rep:
Cystathionine beta lyase / O-succinylhomoserine lyase -
Thermoplasma volcanium
Length = 394
Score = 131 bits (316), Expect = 1e-29
Identities = 72/179 (40%), Positives = 106/179 (59%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSDV+MG ND I K+ + G P P+ YL R +KTL +RME+H K+
Sbjct: 214 YISGHSDVVMGVFSTNDKSIFDKVVVRRKTFGSNPDPIQSYLALRGIKTLGLRMEKHNKN 273
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L P++ V +P EI KK G G+ SF + + + F+ +L
Sbjct: 274 GMELAKYLRTEPRISHVY------YPDTEIGKKVLRGFGGMISF-ELRPELDVHVFMRNL 326
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
KI +A SLGG ESL LP +H+S+ E+R ++GITD+LVR S+G+ED DLI D++
Sbjct: 327 KIPMVAASLGGVESLITLPVETSHSSMTKEERERIGITDNLVRFSIGIEDHVDLIDDIK 385
>UniRef50_A4EYE9 Cluster: Cystathionine beta-lyase/cystathionine
gamma-synthase; n=2; Roseobacter|Rep: Cystathionine
beta-lyase/cystathionine gamma-synthase - Roseobacter
sp. SK209-2-6
Length = 453
Score = 130 bits (314), Expect = 2e-29
Identities = 73/179 (40%), Positives = 101/179 (56%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSD+I G ++ L N G + P C+L+ R LKTL IRM H++S
Sbjct: 252 YLNGHSDLIAGVVAGPRKLVDTVWPRLLNFGGSL-DPHACFLLERGLKTLPIRMRAHEES 310
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L HP V+ VL+P LPSHP H + K +G +F GG + L L
Sbjct: 311 ATALAKFLESHPMVEKVLYPMLPSHPDHALAKSLMKMGTGNVTFFVKGGDMAALALLDHL 370
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ A SLGG ESL LP + A++ ++QRA++GI VRLSVG+ED DLI D +
Sbjct: 371 NLPKQATSLGGVESLISLPFNSSQATMTSKQRAEIGIDPGCVRLSVGIEDAADLIQDFD 429
>UniRef50_Q62BJ4 Cluster: Trans-sulfuration enzyme family protein;
n=15; Burkholderia|Rep: Trans-sulfuration enzyme family
protein - Burkholderia mallei (Pseudomonas mallei)
Length = 433
Score = 129 bits (312), Expect = 3e-29
Identities = 68/181 (37%), Positives = 111/181 (61%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD++ G + + AK+R +++A G P +++ RS++T+ +RM+Q ++
Sbjct: 242 YVGGHSDLV-GGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAART 300
Query: 181 SLIIANWLLKHPKVK-DVLHPGLPSHPQHE-ITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
+ +A WL +P K DV HP L ++ + K+Q +G F+FV GG E+ +F++
Sbjct: 301 ASAVAKWLATNPHQKVDVYHPELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFIN 360
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L +F A SLGG ESL P+ TH+ VP R G+++ L+R+S+GLE EDLIADL
Sbjct: 361 ALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVSEGLIRVSIGLEHEEDLIADL 420
Query: 535 E 537
+
Sbjct: 421 D 421
>UniRef50_Q7W586 Cluster: Cystathionine beta-lyase; n=3;
Bordetella|Rep: Cystathionine beta-lyase - Bordetella
parapertussis
Length = 413
Score = 128 bits (309), Expect = 8e-29
Identities = 68/180 (37%), Positives = 99/180 (55%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+MG +D + +R A G+ SP D YL R ++TL +RM H ++
Sbjct: 232 YLVGHSDVMMGTVTAHDPELWLAIRTEAAAQGLSISPDDAYLATRGIRTLGVRMAAHYRN 291
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+L +A WL HP+V VL+P LP HP H + ++Q G SG+ + + L++ + F+
Sbjct: 292 ALDVAQWLAGHPRVAQVLYPALPQHPDHALWRRQMRGASGLLTLELEPCSLEQRDAFIDR 351
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L +F + S GGYESL V+ + A LVRL +GLED EDL DL+
Sbjct: 352 LTLFAIGASWGGYESL-----VLPADTAGKRSLAGRDYAGPLVRLHIGLEDVEDLKRDLD 406
>UniRef50_Q0LLX7 Cluster: Cystathionine gamma-synthase; n=3;
Bacteria|Rep: Cystathionine gamma-synthase -
Herpetosiphon aurantiacus ATCC 23779
Length = 372
Score = 128 bits (308), Expect = 1e-28
Identities = 73/180 (40%), Positives = 107/180 (59%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIA--AKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHK 174
Y+ GHSDV+ G A++ V +L+ + G VPSP +C+L+ R +++LA R+ H
Sbjct: 195 YLGGHSDVL-GGALITKTVTPWWQRLQQIHVLAGAVPSPFECWLILRGMQSLAYRLRGHC 253
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
++L +A WL +HPKV+ V +PGL SHPQ E+ ++Q G+ SF VGG E+ +
Sbjct: 254 ANALAVAEWLAQHPKVQAVHYPGLTSHPQFELAQRQMLLMGGMVSFEVVGGAAEAIAVAA 313
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+K++T A SLGG ESL E + + P +L+RLSVGLE +DLIADL
Sbjct: 314 HVKLWTRATSLGGPESLIEHRATLEGPDSPT--------PPALLRLSVGLEHPDDLIADL 365
>UniRef50_P24601 Cluster: Probable cystathionine gamma-synthase (EC
2.5.1.48) (CGS) (O- succinylhomoserine (thiol)-lyase);
n=52; cellular organisms|Rep: Probable cystathionine
gamma-synthase (EC 2.5.1.48) (CGS) (O-
succinylhomoserine (thiol)-lyase) - Herpetosiphon
aurantiacus (Herpetosiphon giganteus)
Length = 319
Score = 128 bits (308), Expect = 1e-28
Identities = 56/122 (45%), Positives = 84/122 (68%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ GA + ++ + KL+FLQNA G VP P DC+LV R +KTL+IRM +++
Sbjct: 198 YIGGHSDVVGGAIMTSNDELYEKLKFLQNAAGAVPGPFDCWLVLRGVKTLSIRMRDDERN 257
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L IA +L +HP V+ V++PGLPSHPQH + ++Q G G+ S + GG + +N +S
Sbjct: 258 ALAIAQFLTEHPGVEKVIYPGLPSHPQHNLAREQMRGFGGMISILLKGGAEAANAMVSKT 317
Query: 361 KI 366
K+
Sbjct: 318 KL 319
>UniRef50_Q0APK0 Cluster: Cystathionine beta-lyase; n=1; Maricaulis
maris MCS10|Rep: Cystathionine beta-lyase - Maricaulis
maris (strain MCS10)
Length = 385
Score = 127 bits (307), Expect = 1e-28
Identities = 69/180 (38%), Positives = 100/180 (55%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD++MGA + D + +L+ + A G P D YL R L+++ +RM++ +S
Sbjct: 201 YVGGHSDLLMGAVVARDDALFQRLQTTERAFGFHTGPDDAYLALRGLRSMGVRMQRSAES 260
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVG-GLKESNKFLSS 357
SL IA WL +V + HP HP H + K+ SG G+F+F G + S FL +
Sbjct: 261 SLTIAEWLAARAEVGAIRHPARSDHPDHALFKRDFSGACGLFAFEVPGWDIATSEHFLDA 320
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++F + S GGYESLA + A + +L+RLS+GLE EDLIADLE
Sbjct: 321 LEVFGMGFSWGGYESLAIHCDPQLKRTKTAHKH-----DGALIRLSIGLEAPEDLIADLE 375
>UniRef50_Q5QU17 Cluster: Methionine gamma-lyase; n=29; cellular
organisms|Rep: Methionine gamma-lyase - Idiomarina
loihiensis
Length = 408
Score = 127 bits (306), Expect = 2e-28
Identities = 65/179 (36%), Positives = 103/179 (57%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++NGH DV+ G +D I MG SP D +L+ R LKTL +RM++H ++
Sbjct: 216 FLNGHGDVVAGIICGSDDDINTIKSTTLKDMGATISPHDAWLILRGLKTLDVRMQRHCEN 275
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ + ++L +K + +PG P H + KQ S + V +F G ++ FL+ L
Sbjct: 276 ADAVYDFLAARQDIKKIYYPGAPDHEAQALMGKQMSRNGAVIAFELEGDEAKARYFLNQL 335
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ LA SLG E+L + P+ MTH+ E R + GI+D+L+R++VGLE +D+IADLE
Sbjct: 336 RMIALAVSLGDAETLIQHPASMTHSPYTPEARLKAGISDTLIRIAVGLEAADDIIADLE 394
>UniRef50_Q01X62 Cluster: Cystathionine gamma-synthase; n=1;
Solibacter usitatus Ellin6076|Rep: Cystathionine
gamma-synthase - Solibacter usitatus (strain Ellin6076)
Length = 415
Score = 126 bits (304), Expect = 3e-28
Identities = 68/180 (37%), Positives = 108/180 (60%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++G+SD++ G AI + I KLR +++ G + P +C++++ L T+A+RM + K+
Sbjct: 230 YLSGYSDMLGGVAITDSADIVQKLRSVRSMFGNILQPDECWMLDSRLSTVALRMNRQSKN 289
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHP-QHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
+ +A L H + V++P L + P Q I +KQ G+FS GG + + +FL
Sbjct: 290 AQRLAEALHGHRLLSQVIYPTLFTDPEQKRIFEKQCDFPGGMFSIEFKGGKEAAFQFLRH 349
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++I A SLG ESL P TH+ + AE+ A+ G+TD LVR+SVG+ED DL+AD E
Sbjct: 350 VRIARNAVSLGSVESLTCHPKSTTHSGMSAEELAESGVTDGLVRISVGIEDWRDLLADFE 409
>UniRef50_Q38DH3 Cluster: Cystathione gamma lyase, putative; n=7;
Trypanosomatidae|Rep: Cystathione gamma lyase, putative
- Trypanosoma brucei
Length = 445
Score = 126 bits (304), Expect = 3e-28
Identities = 65/182 (35%), Positives = 108/182 (59%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++GH+ + GA + + KLR QN +G SP +L +++KT+++R+ + +
Sbjct: 256 FVDGHNMTVGGALVTKRKDLDEKLRLTQNILGNAMSPFVAFLQLQTMKTMSLRVTKQSAN 315
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSG--HSGVFSFVHVGGLKESNKFLS 354
+ +A +L HP V V +PGL S PQ E+ +Q S H G+ F GG + +
Sbjct: 316 AQKVAEFLETHPIVDKVSYPGLKSFPQKELADRQHSNGNHGGMLWFELKGGTAAGRRLMD 375
Query: 355 SL-KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
++ + ++L E+LG ES+ PSVMTHA++ E R ++GITD +R+S G+ED EDL+A
Sbjct: 376 TVQRPWSLCENLGATESIITCPSVMTHANMTTEDRLKVGITDGFIRVSCGIEDAEDLVAA 435
Query: 532 LE 537
L+
Sbjct: 436 LK 437
>UniRef50_Q96VU8 Cluster: Cystathionine beta-lyase; n=3;
Pezizomycotina|Rep: Cystathionine beta-lyase -
Neurospora crassa
Length = 457
Score = 126 bits (304), Expect = 3e-28
Identities = 68/178 (38%), Positives = 105/178 (58%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GH D++ G VND + KL F NA G SP D +L+ R +KTLAIRME+ + +
Sbjct: 238 YLSGHHDIMAGVIAVNDTELGDKLYFTINATGCGLSPNDSFLLMRGVKTLAIRMEKQQAN 297
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L H V +PGL SHPQ+++ G V SF G + S + + +
Sbjct: 298 AQRIAEFLESHG--FKVRYPGLKSHPQYDLHWSMARGAGAVLSF-ETGDVALSERIVEAA 354
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+++ ++ S G SL +P M+HAS+ A+ RA+ + + ++RL VG+ED +DLI DL
Sbjct: 355 RLWGISVSFGCVNSLISMPCRMSHASIDAKTRAERQMPEDIIRLCVGIEDADDLIDDL 412
>UniRef50_A7H124 Cluster: Methionine gamma-lyase; n=2;
Campylobacter|Rep: Methionine gamma-lyase -
Campylobacter curvus 525.92
Length = 380
Score = 126 bits (303), Expect = 4e-28
Identities = 67/179 (37%), Positives = 104/179 (58%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DVI G ND +A ++ F++N +G SP D Y + R LKTL++R ++ ++
Sbjct: 195 YIGGHADVIAGIVSTNDDALADRIAFMKNTLGATLSPTDAYYLIRGLKTLSVRFDRQTQN 254
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ I +L + V+ V + G S + + Q S V S G + KF SL
Sbjct: 255 THKIVEFLKSNSAVRTVYYAGSYSEFEKRAQEAQASDIGAVISLELAEGY-DYEKFAKSL 313
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+F LA SLGG ESL P+ MTH S P E + ++GI+ +L+RL++G+E+ +DLI DL+
Sbjct: 314 HLFDLAVSLGGVESLICHPASMTHESYPKELQEKIGISQNLLRLAIGIENADDLIDDLK 372
>UniRef50_A0NJV2 Cluster: O-succinylhomoserine thiol-lyase; n=2;
Leuconostocaceae|Rep: O-succinylhomoserine thiol-lyase -
Oenococcus oeni ATCC BAA-1163
Length = 369
Score = 126 bits (303), Expect = 4e-28
Identities = 71/179 (39%), Positives = 107/179 (59%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D++ G + + ++ L+ G V P C+L+ RSLKTL++R+++H S
Sbjct: 201 YLGGHNDILAGVVVSSRSELSKSLQENLITRGQVLDPFSCWLLLRSLKTLSLRVQRHSSS 260
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA L K V +L+PGL G+ SF G +++KFL L
Sbjct: 261 AQYIAKVLTKINGVDKILYPGL----------------GGMISFYLSDGY-DTDKFLQGL 303
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+F+ AESLGG ESL +PS+ TH + ++R +LGITD+LVR+SVGLED +DL+ DL+
Sbjct: 304 KLFSFAESLGGAESLITIPSIQTHHDMSQQRRNELGITDNLVRVSVGLEDKDDLLDDLK 362
>UniRef50_Q97PS4 Cluster: Transulfuration enzyme family protein;
n=25; Lactobacillales|Rep: Transulfuration enzyme family
protein - Streptococcus pneumoniae
Length = 364
Score = 125 bits (302), Expect = 6e-28
Identities = 73/178 (41%), Positives = 100/178 (56%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+ G + N + KL + N G V SP D Y + R LKTL++RME+ +
Sbjct: 198 YLAGHNDVLAGVVVTNSLELYEKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTAN 257
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ + +L P VK+VL+ +G G+ SF V L+SL
Sbjct: 258 AQEVVAFLKDSPAVKEVLY----------------TGRGGMISF-KVADETRIPHILNSL 300
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+F+ AESLGG ESL P+ THA +PAE R G+TD L+RLS+G+ED DLIADL
Sbjct: 301 KVFSFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADL 358
>UniRef50_Q1AT24 Cluster: Cystathionine gamma-synthase; n=2;
Bacteria|Rep: Cystathionine gamma-synthase - Rubrobacter
xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 410
Score = 125 bits (301), Expect = 7e-28
Identities = 66/180 (36%), Positives = 104/180 (57%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GH DV G AA L ++ +G P + +L++R LKTL +R+ + +
Sbjct: 226 YLSGHGDVTAGVVAAGPPYDAA-LEQIRKTVGSTLGPFEAWLLHRGLKTLPLRISRQCAN 284
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+ IA WL +HPKV V HP L HP E T + + G+ +F + G + + +FL++
Sbjct: 285 ARRIAAWLAEHPKVFRVHHPSLEGHPDREATGRLLADTGGLVAFELAAEGREAAFRFLNA 344
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++ A SLG +LA P+ +H +P +R QLG+ ++L+RLS G+E ED+IADLE
Sbjct: 345 LRLCVRAPSLGDIYTLAIHPATSSHRELPPSRREQLGVRENLIRLSAGIEHPEDIIADLE 404
>UniRef50_P55218 Cluster: O-succinylhomoserine sulfhydrylase; n=95;
Proteobacteria|Rep: O-succinylhomoserine sulfhydrylase -
Pseudomonas aeruginosa
Length = 403
Score = 125 bits (301), Expect = 7e-28
Identities = 64/170 (37%), Positives = 102/170 (60%), Gaps = 1/170 (0%)
Frame = +1
Query: 28 MGAAIVNDGV-IAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWL 204
MG + G + + FL+ A G SP + +L + L+TL IRM+ H S+L +A WL
Sbjct: 228 MGGVVAGRGEQMKEVVGFLRTA-GPTLSPFNAWLFLKGLETLRIRMQAHSASALALAEWL 286
Query: 205 LKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAES 384
+ P ++ V + GLPSHPQHE+ ++Q SG V SF GG + +F+ + ++ ++ +
Sbjct: 287 ERQPGIERVYYAGLPSHPQHELARRQQSGFGAVVSFDVKGGRDAAWRFIDATRMVSITTN 346
Query: 385 LGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
LG ++ P+ +H + E RA+ GI DSL+R++VGLED +DL AD+
Sbjct: 347 LGDTKTTIAHPATTSHGRLSPEDRARAGIGDSLIRVAVGLEDLDDLKADM 396
>UniRef50_O02215 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 451
Score = 124 bits (300), Expect = 1e-27
Identities = 70/178 (39%), Positives = 100/178 (56%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DVI G V+ KL+ Q G SP D L+ R LKTL +R+++ ++
Sbjct: 268 YIGGHTDVIAGVVTVSSYDNWKKLKLQQLTTGSSLSPYDAALLTRGLKTLGLRVDRISEN 327
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ A +L HPKV+ V +PGLPSHPQH+ K+ +G+ +F VG + + K + SL
Sbjct: 328 AQKTAEFLESHPKVERVFYPGLPSHPQHQYAKQVMKQFAGMIAF-DVGTAENAIKLVESL 386
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+ A SLGG ESL E P M+H + L+R SVG+E+ ED+I DL
Sbjct: 387 KLIIHAVSLGGTESLIEHPLSMSHGKHLLRYLDGPTVAPGLLRFSVGIENVEDIIGDL 444
>UniRef50_Q9KCE4 Cluster: Cystathionine gamma-synthase
(O-succinylhomoserine (Thiol)-lyase); n=44;
Bacteria|Rep: Cystathionine gamma-synthase
(O-succinylhomoserine (Thiol)-lyase) - Bacillus
halodurans
Length = 378
Score = 124 bits (298), Expect = 2e-27
Identities = 70/179 (39%), Positives = 100/179 (55%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DVI G + + ++ + N +G S D +L+ R +KTLA+RMEQH+ +
Sbjct: 199 YLGGHNDVIAGLIVAKGQELCEQIAYYHNGIGGTLSAFDSWLLIRGMKTLALRMEQHQNN 258
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA++L KH V DVL+PG G+ SF + N FL SL
Sbjct: 259 ARAIASYLEKHEGVTDVLYPG----------------RGGMLSF-RIQSESWVNPFLQSL 301
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+ + AESLGG ESL P+ THA +P + R G+ + L+R SVG+E DLIADL+
Sbjct: 302 KLISFAESLGGVESLMTYPATQTHADIPEDVRIANGVCNRLLRFSVGIEHVGDLIADLD 360
>UniRef50_A5G088 Cluster: Cystathionine gamma-synthase; n=1;
Acidiphilium cryptum JF-5|Rep: Cystathionine
gamma-synthase - Acidiphilium cryptum (strain JF-5)
Length = 416
Score = 124 bits (298), Expect = 2e-27
Identities = 69/180 (38%), Positives = 101/180 (56%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSD ++G AI + LR + MG P +L+ RS++T+ +R+E+ ++
Sbjct: 231 YAGGHSD-LLGGAISGATALVEPLRKRRTLMGTHLDPHGSWLLLRSIETMGLRVERAGQN 289
Query: 181 SLIIANWLLKHPKVKDVLHPGL--PSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
+ +A +L HPKV V G P+ P + ++Q G F+F GG + L
Sbjct: 290 AATVARFLAAHPKVSRVTWAGFADPASPAGALLRRQCDGAGPTFAFDVAGGEASCFRLLD 349
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L++F LA SLGG ESL P+ TH SVP E+RA G+TD +R+SVG+E DLI DL
Sbjct: 350 ALRVFRLAVSLGGTESLICHPATTTHFSVPPERRAAAGVTDGTIRISVGIEHEADLIEDL 409
>UniRef50_A5CVL3 Cluster: O-succinylhomoserine sulfhydrylase; n=3;
Bacteria|Rep: O-succinylhomoserine sulfhydrylase -
Vesicomyosocius okutanii subsp. Calyptogena okutanii
(strain HA)
Length = 388
Score = 124 bits (298), Expect = 2e-27
Identities = 64/179 (35%), Positives = 102/179 (56%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++G + G + +I RFL+ G S + ++V + L TL++RM+ H +
Sbjct: 207 YIDGQGRCLAGVIAGSTDIIEQIHRFLRTT-GPSLSAFNAWIVLKGLDTLSLRMKAHSDN 265
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A WL +V+ V + GLPSHP H + K Q SG G+ SF GG K + K +++
Sbjct: 266 ALKLAIWLEAQDQVEKVYYLGLPSHPDHNLAKSQQSGFGGIVSFKIKGGKKSAFKIINAT 325
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
I ++ +LG +S P+ TH + E+R ITD L+R+SVGLED +D+IAD++
Sbjct: 326 NILSITANLGDTKSTITHPATTTHGRLTDEERLNAHITDGLIRISVGLEDIKDIIADIK 384
>UniRef50_A1SSS1 Cluster: Cystathionine beta-lyase; n=10;
Gammaproteobacteria|Rep: Cystathionine beta-lyase -
Psychromonas ingrahamii (strain 37)
Length = 407
Score = 122 bits (295), Expect = 4e-27
Identities = 73/180 (40%), Positives = 100/180 (55%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+MG A N LR +G SP D YL +R L+TL +RM QH+K+
Sbjct: 221 YIVGHSDVMMGTATANTKYWPT-LREHSYLLGQCTSPDDVYLASRGLRTLGVRMAQHEKN 279
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV-HVGGLKESNKFLSS 357
+L +ANWL P+V + HP + P HE K+ SG +G+FSFV G LK + +
Sbjct: 280 ALAVANWLATRPEVDHLRHPAFETCPGHEFFKRDFSGSNGLFSFVLKEGNLKSVTALVEN 339
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ F + S GG+ESL + V + Q + L+RL VGLE+ +DLIADLE
Sbjct: 340 MDYFKMGFSWGGFESL--ILGVFGIDKI--RTVTQWDKSKPLIRLHVGLENVDDLIADLE 395
>UniRef50_Q7WM51 Cluster: Cystathionase beta-lyase; n=3;
Proteobacteria|Rep: Cystathionase beta-lyase -
Bordetella bronchiseptica (Alcaligenes bronchisepticus)
Length = 408
Score = 122 bits (294), Expect = 5e-27
Identities = 71/181 (39%), Positives = 107/181 (59%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSDV+MG + A L +A G+ SP D YLV R +++LA R+ H++
Sbjct: 214 YLSGHSDVMMGTVATTEAAWPA-LSERSDAFGMTVSPDDAYLVLRGIRSLAARLAMHERH 272
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKE--SNKFLS 354
+L IA +L + P+V+ V P LP HP H+I ++ +G +G+ SF G + +++
Sbjct: 273 ALRIAGYLQERPEVRTVFCPALPGHPGHDIWRRDCTGTNGLLSFELQAGFDRAAAEQWID 332
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
SL +F L S GGYESL L + SV A+ + G+ +VRL +GLED +DLIADL
Sbjct: 333 SLALFGLGASWGGYESLVTLADLGAARSV-ADWSGR-GV---VVRLHIGLEDPQDLIADL 387
Query: 535 E 537
+
Sbjct: 388 D 388
>UniRef50_A4AND2 Cluster: Cystathionine gamma-lyase; n=2; cellular
organisms|Rep: Cystathionine gamma-lyase -
Flavobacteriales bacterium HTCC2170
Length = 396
Score = 122 bits (294), Expect = 5e-27
Identities = 64/180 (35%), Positives = 108/180 (60%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+I G I + + +G +PM+ +L+ RSL+TL +R+++H+ +
Sbjct: 210 YLGGHSDLIGGVVIGAQKEVDSIFHNEYELLGAKTAPMEAWLLLRSLRTLTMRVKRHQSN 269
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
++ IA +L H +++ V +PGL S PQ E+ KKQ +G +G+ SF + L E F++
Sbjct: 270 AMAIAEFLEGHSQIEFVRYPGLNSFPQGELYKKQMTGSTGLMSFNLKTENLVEIKSFVNR 329
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L +F + S GG+ESL +P++ + +Q +GI+ +R+SVGLE +DLI DL+
Sbjct: 330 LSVFQIGVSWGGHESLVFVPAISYLKELDEKQFKNMGISLGDIRISVGLEHVDDLITDLK 389
>UniRef50_Q2JBH0 Cluster: O-succinylhomoserine sulfhydrylase; n=1;
Frankia sp. CcI3|Rep: O-succinylhomoserine sulfhydrylase
- Frankia sp. (strain CcI3)
Length = 409
Score = 122 bits (293), Expect = 7e-27
Identities = 60/168 (35%), Positives = 93/168 (55%)
Frame = +1
Query: 31 GAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLK 210
G + + ++L + G SP + ++ +SL+TL +RM H ++ ++A WL
Sbjct: 227 GGVVAGRAGLISELHGVLRTAGPSLSPFNAWIFLKSLETLPVRMRAHDANTAVVAAWLAD 286
Query: 211 HPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLG 390
P V+ V + G HPQ E+ Q SGH GV SF GG + S F+ L++ + ++G
Sbjct: 287 QPDVRAVHYTGSADHPQRELVAAQQSGHGGVISFELYGGQQASWSFVDRLELVSNTTNIG 346
Query: 391 GYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+S+ P+ TH + QR G+TD L+RLSVGLED ED++ADL
Sbjct: 347 DTKSMITHPASTTHGRLTPAQRDSAGVTDGLLRLSVGLEDVEDIVADL 394
>UniRef50_Q4PK57 Cluster: Predicted cystathionine beta-lyase; n=1;
uncultured bacterium MedeBAC49C08|Rep: Predicted
cystathionine beta-lyase - uncultured bacterium
MedeBAC49C08
Length = 262
Score = 122 bits (293), Expect = 7e-27
Identities = 60/130 (46%), Positives = 82/130 (63%), Gaps = 2/130 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVI--AAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHK 174
Y+ GHSDVIMG ++ D + ++ + N++G + SP D YL RSLKTLA+RME+H
Sbjct: 129 YLCGHSDVIMGVLVMKDAESDNSKRISNIHNSLGPISSPFDSYLALRSLKTLALRMERHS 188
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLS 354
++ IA++L HPK+ V++PGL SHPQH + KKQ G+ S GLK S FL
Sbjct: 189 SNAEKIADFLESHPKISKVIYPGLESHPQHSVAKKQMDFFGGMISAEIKDGLKASKNFLE 248
Query: 355 SLKIFTLAES 384
+FTLAES
Sbjct: 249 RTSLFTLAES 258
>UniRef50_Q1ELY9 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=1; uncultured Thermotogales
bacterium|Rep: Cystathionine beta-lyases/cystathionine
gamma-synthases - uncultured Thermotogales bacterium
Length = 380
Score = 122 bits (293), Expect = 7e-27
Identities = 69/179 (38%), Positives = 105/179 (58%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGHSDVI G A + + + R +G +P + +LV R +KTL +RME H +
Sbjct: 199 YVNGHSDVIAGFAAFRNRELETRARKKMIKLGTNGAPFEAFLVCRGVKTLGLRMELHNNN 258
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L K PKV V HP L S + G GV ++ V L+ + +F+
Sbjct: 259 AKEIALFLSKSPKVSLVSHPSLKSAVPNCFA--DCKGFGGVV-YLEVKDLETAKEFIRKS 315
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++F A SL G ESLA +P + +H+S +EQ ++G+++ VRLSVG+E+ EDL+ADL+
Sbjct: 316 ELFLEATSLAGVESLATIPVLTSHSSFTSEQLCEVGLSEGGVRLSVGIENIEDLLADLD 374
>UniRef50_Q2AGF7 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=1; Halothermothrix orenii H 168|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Halothermothrix orenii H 168
Length = 397
Score = 121 bits (292), Expect = 9e-27
Identities = 63/180 (35%), Positives = 103/180 (57%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRF-LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+ GH + I G IV K+R L G SP + +L + L+TL++RME+H
Sbjct: 214 YIGGHGNSI-GGVIVGTRDFIHKVRTELYRDTGPAISPFNAWLFIQGLETLSLRMEKHCS 272
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
+++ +A WL +V+ V +PGLP HP+HE+ KKQ G G+ F GG + ++
Sbjct: 273 NAMEVARWLSGDERVEWVTYPGLPDHPRHELAKKQQRGFGGMICFGVKGGYSAARNLINR 332
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+++ +L ++G +L P+ TH + E++ + G+T L+RLSVG+ED D+I DL+
Sbjct: 333 VELCSLLANIGDTRTLIIHPASTTHEQLSREEQEKAGVTPDLIRLSVGIEDVWDIIDDLD 392
>UniRef50_P44527 Cluster: Cystathionine beta-lyase; n=78;
Gammaproteobacteria|Rep: Cystathionine beta-lyase -
Haemophilus influenzae
Length = 396
Score = 121 bits (292), Expect = 9e-27
Identities = 69/183 (37%), Positives = 107/183 (58%), Gaps = 4/183 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+++G A+ N +LR MG + Y R ++TL +R++QH++S
Sbjct: 212 YLVGHSDIMIGTAVANARTWD-QLREHSYLMGQMVDADSAYTTARGIRTLGVRLKQHQES 270
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGL--KESNKFLS 354
S+ +A WL + P+VK V HP LPS P HE + SG SG+FSF L ++ +KF+
Sbjct: 271 SIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRLTSEQVSKFMD 330
Query: 355 SLKIFTLAESLGGYES--LAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIA 528
++F +A S GG+ES L P + H P +R +T SL+R+ +G E+ ++LIA
Sbjct: 331 HFQLFAMAYSWGGFESLILCNQPEEIAHIR-PNIKR---NLTGSLIRVHIGFENVDELIA 386
Query: 529 DLE 537
DL+
Sbjct: 387 DLK 389
>UniRef50_Q52811 Cluster: Putative cystathionine beta-lyase; n=35;
Proteobacteria|Rep: Putative cystathionine beta-lyase -
Rhizobium leguminosarum bv. viciae (strain 3841)
Length = 396
Score = 121 bits (291), Expect = 1e-26
Identities = 70/184 (38%), Positives = 101/184 (54%), Gaps = 5/184 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +GHSD+++G N +L+ +GI +P D Y + R L+T+ +R+E+H +S
Sbjct: 211 YPSGHSDILLGTVSAN-AEHWERLKEANGVLGICGAPDDAYQILRGLRTMGLRLERHYES 269
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNK----- 345
+L IA WL V VLHP LPS P H + K+ G SG+FSFV E ++
Sbjct: 270 ALDIAKWLEGRDDVARVLHPALPSFPSHHLWKRDFKGASGIFSFVLAADGPEKSRAKAHA 329
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
FL +L+IF L S GG+ESLA HA + A+ ++RL +G+ED DL
Sbjct: 330 FLDALRIFGLGYSWGGFESLA------LHAYLNDRTVAKAPTDGPVIRLQIGIEDVADLK 383
Query: 526 ADLE 537
AD+E
Sbjct: 384 ADIE 387
>UniRef50_P44502 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=14;
Bacteria|Rep: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase) - Haemophilus
influenzae
Length = 369
Score = 120 bits (290), Expect = 2e-26
Identities = 65/178 (36%), Positives = 101/178 (56%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D ++G + + ++ ++QN G V SP D +L R +KTL++RM++H+++
Sbjct: 201 YIAGHNDALVGLIVAKGQELCDRIAYIQNGAGAVLSPFDSWLTIRGMKTLSLRMKRHQEN 260
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L P+V+ VL+P G+ SF + N FL S+
Sbjct: 261 AQAIAEFLKAQPQVESVLYPN----------------KGGMLSF-RLQDEAWVNTFLKSI 303
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+ T AESLGG ES P+ TH +P +R GIT++L+R SVG+ED ED+ ADL
Sbjct: 304 KLITFAESLGGTESFITYPATQTHMDIPESERVARGITNTLLRFSVGIEDVEDIKADL 361
>UniRef50_A7H1V2 Cluster: Cystathionine beta-lyase; n=15;
Campylobacter|Rep: Cystathionine beta-lyase -
Campylobacter jejuni subsp. doylei 269.97
Length = 387
Score = 120 bits (289), Expect = 2e-26
Identities = 67/180 (37%), Positives = 98/180 (54%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSDV MG ++N+ L A+G SP D YLV R ++TL +RM+ H+KS
Sbjct: 207 YLSGHSDVTMGIVVINEKEWK-NFDKLPEALGFTTSPDDAYLVLRGMRTLDVRMKAHEKS 265
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESN--KFLS 354
+ I +L ++K + +P L SHP HEI + G +G+ + G + + KF+
Sbjct: 266 ADEIVEFLQSRKEIKTIFYPKLKSHPNHEIFMRDHKGVNGMITIEFAEGYNKDDAIKFVD 325
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L+ F++ S GGYESLA + + P L VR +GLEDT+DLIADL
Sbjct: 326 KLEYFSIGASWGGYESLATV-------TTPPRTATDLSARGPFVRFHIGLEDTKDLIADL 378
>UniRef50_A0VE37 Cluster: Cystathionine beta-lyase; n=2;
Comamonadaceae|Rep: Cystathionine beta-lyase - Delftia
acidovorans SPH-1
Length = 407
Score = 120 bits (289), Expect = 2e-26
Identities = 72/181 (39%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G I + ++ K+ A+G+ D YL R L+TL +R+ QH++
Sbjct: 218 YIAGHSDVMQGIVITDGPALSKKISTAYEALGLTIGADDAYLALRGLRTLPVRLAQHQRH 277
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLK--ESNKFLS 354
+ IA WL + P+V V +P LPS P H + K+ SG SG+ SF G+ F+
Sbjct: 278 ATEIAQWLEQQPQVGRVFYPALPSDPGHALWKRDFSGASGLVSFAFAEGVDAGAGAVFVD 337
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
SL+ F S GGYESLA ++ E G T +VRL VGLED DLIADL
Sbjct: 338 SLQQFAQGASWGGYESLA----LVAQPERLREHSVWTG-TAPVVRLHVGLEDPLDLIADL 392
Query: 535 E 537
E
Sbjct: 393 E 393
>UniRef50_A0JSU6 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=7;
Actinomycetales|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Arthrobacter sp.
(strain FB24)
Length = 394
Score = 120 bits (289), Expect = 2e-26
Identities = 69/184 (37%), Positives = 106/184 (57%), Gaps = 5/184 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV++GA + +D I AKL + G + P + +L R L+TLA+R+E+ + S
Sbjct: 211 YLAGHSDVVLGALVTSDAAIRAKLLHHRIIHGGIAGPFEAWLALRGLRTLALRIERSQAS 270
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVF--SFVHVGGLK---ESNK 345
+ ++A L HP+++ + PGL + P H+ K Q G + GGL ++K
Sbjct: 271 AAVLAGRLSNHPRIESIRFPGLETDPGHDRAKSQMKGFGSILCVQIAPAGGLNGADAADK 330
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
+ +L+++ A SLGG ESL E HA+ P + + D+LVRLSVG+E+ EDL
Sbjct: 331 LVRALQLWLPATSLGGVESLIE--RRRRHAAEP------VSVPDNLVRLSVGIENVEDLW 382
Query: 526 ADLE 537
ADLE
Sbjct: 383 ADLE 386
>UniRef50_A3UCF8 Cluster: Cystathionine beta-lyase; n=1;
Oceanicaulis alexandrii HTCC2633|Rep: Cystathionine
beta-lyase - Oceanicaulis alexandrii HTCC2633
Length = 381
Score = 120 bits (288), Expect = 3e-26
Identities = 77/179 (43%), Positives = 97/179 (54%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSD +MG+ G AA+L+ G SP D YL R L+TL +R+E+ S
Sbjct: 204 YAGGHSDFLMGSVAAR-GESAARLKDKDVLFGGHVSPDDAYLCLRGLRTLLLRIERSGAS 262
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVG-GLKESNKFLSS 357
L IA L HPK+ VLHPGL SHP H + Q +G SG F+FV G ++S +
Sbjct: 263 GLHIARQLEAHPKIARVLHPGLQSHPDHALFNSQFTGASGCFAFVLDGVNARDSEAMAEA 322
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+F L S GGYESL LP +A+ +L+RLSVGLED EDL ADL
Sbjct: 323 CHLFRLGFSWGGYESLI-LPCDRQIRRTAVAWQAE----GALLRLSVGLEDAEDLWADL 376
>UniRef50_Q6AJ03 Cluster: Probable cystathionine beta-lyase; n=1;
Desulfotalea psychrophila|Rep: Probable cystathionine
beta-lyase - Desulfotalea psychrophila
Length = 386
Score = 119 bits (286), Expect = 5e-26
Identities = 66/180 (36%), Positives = 101/180 (56%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSD+++G A VN R+ Q+ P P DCY R LKTL +R++ H++S
Sbjct: 209 YISGHSDILLGTATVNHKYADILARYYQSLELFAP-PADCYAALRGLKTLHVRLKHHEQS 267
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV--HVGGLKESNKFLS 354
+L IA+WL P+ ++HP P HPQH KK +G G+F+F KE +F++
Sbjct: 268 ALQIADWLESQPQTGRIIHPARPDHPQHSRWKKYFTGSCGLFAFTFKKEPSEKELGEFIN 327
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L++F + S GGY+SL + + S L +++RL++GLE EDL DL
Sbjct: 328 ALQLFGIGYSWGGYKSLITAGKYVRNGS-------DLN-GSTVIRLNIGLEAVEDLCHDL 379
>UniRef50_A6UGP2 Cluster: Cystathionine gamma-synthase; n=1;
Sinorhizobium medicae WSM419|Rep: Cystathionine
gamma-synthase - Sinorhizobium medicae WSM419
Length = 400
Score = 119 bits (286), Expect = 5e-26
Identities = 60/184 (32%), Positives = 105/184 (57%), Gaps = 5/184 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAK----LRF-LQNAMGIVPSPMDCYLVNRSLKTLAIRME 165
++ GH+D + G + ++ +R+ N +G SP + +L+ R +TLA+R+E
Sbjct: 208 FIGGHNDAVGGVITLKSDILPPDWLEDVRWNTLNKLGAPLSPFNAWLLLRGAQTLALRLE 267
Query: 166 QHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNK 345
+ ++L +A L HP+V+ V +PGLPSHP + K+Q G + SF V +
Sbjct: 268 KQCANALALAKHLEAHPRVRRVFYPGLPSHPNYASAKEQLRGGGAMLSF-QVDDEASGVR 326
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
L L++ + A SLGG + ++P+ M +P+++R +G+ D LVR SVG+E +D+I
Sbjct: 327 LLKRLQLCSFAASLGGLRTTTQVPATMAFLDIPSQEREAMGVVDGLVRFSVGIEHIDDII 386
Query: 526 ADLE 537
AD++
Sbjct: 387 ADVD 390
>UniRef50_Q07703 Cluster: Cystathionine beta-lyase; n=6;
Burkholderiales|Rep: Cystathionine beta-lyase -
Bordetella avium
Length = 396
Score = 118 bits (285), Expect = 6e-26
Identities = 66/179 (36%), Positives = 106/179 (59%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+++GA + ND IA +L Q A+G S D +L R ++T+ +RM QH +
Sbjct: 215 YVGGHSDLMLGAVVTNDEAIAKRLNRTQYALGYSVSADDAWLALRGVRTMPVRMAQHARH 274
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVG-GLKESNKFLSS 357
+L + +L P+V + HP P+ P H + ++ SG +G+ + V +G + + F+++
Sbjct: 275 ALEVCEFLQNRPEVVRLYHPAWPADPGHALWQRDCSGSNGMLA-VQLGLSPQAARDFVNA 333
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L +F + S GG+ESL +L +T + Q Q G +D+LVRL +GLE DLIADL
Sbjct: 334 LTLFGIGFSWGGFESLVQL---VTPGELARHQYWQ-GGSDALVRLHIGLESPADLIADL 388
>UniRef50_Q1GNK9 Cluster: Cystathionine beta-lyase; n=4;
Sphingomonadales|Rep: Cystathionine beta-lyase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 400
Score = 117 bits (282), Expect = 1e-25
Identities = 76/182 (41%), Positives = 101/182 (55%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD +MG+ V KLR +G SP DC L+ R L+TL +RM++H ++
Sbjct: 219 YVGGHSDAMMGSLTATRAVWP-KLRSAAYQLGQAVSPDDCALMLRGLRTLDVRMQRHGEN 277
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES-NKFLSS 357
L++ANWL +V VLHP L H I + SG SG+F F G + + +F+ +
Sbjct: 278 GLVVANWLAARGEVGRVLHPALAGDGGHAIWARDFSGPSGLFGFTLKGADEGARTRFIDA 337
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGIT--DSLVRLSVGLEDTEDLIAD 531
L F + S GGYESL +P + PA R T D LVRLS+GLED DLIAD
Sbjct: 338 LTQFGIGFSWGGYESLV-VP------ADPAGIRTATRWTDPDPLVRLSIGLEDPADLIAD 390
Query: 532 LE 537
LE
Sbjct: 391 LE 392
>UniRef50_A6PIC3 Cluster: Cystathionine beta-lyase; n=1; Shewanella
sediminis HAW-EB3|Rep: Cystathionine beta-lyase -
Shewanella sediminis HAW-EB3
Length = 411
Score = 117 bits (282), Expect = 1e-25
Identities = 68/180 (37%), Positives = 99/180 (55%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+MG A N+ +LR MG SP D YL NR L+TL +RM+QH+++
Sbjct: 224 YIVGHSDVMMGTATSNEAHWD-QLRENSYLMGQCTSPDDVYLANRGLRTLGVRMQQHEQN 282
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV-HVGGLKESNKFLSS 357
+L +ANWL P+V + HP + P H+ K+ S +G+FSFV G L + +
Sbjct: 283 ALKVANWLATRPEVDHIRHPAFDTCPGHQFFKRDFSASNGLFSFVLKEGDLNSVTALVEN 342
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ F + S GG+ESL + + + L+RL +GLE+ +DLIADLE
Sbjct: 343 MHHFKMGFSWGGFESLI----LGVFGIDKLRTATKWDSSKPLIRLHIGLENPDDLIADLE 398
>UniRef50_Q9V088 Cluster: MetB cystathionine gamma-synthase (EC
4.2.99.9) (CGS) (O- succinylhomoserine (Thiol)-lyase);
n=9; Archaea|Rep: MetB cystathionine gamma-synthase (EC
4.2.99.9) (CGS) (O- succinylhomoserine (Thiol)-lyase) -
Pyrococcus abyssi
Length = 393
Score = 117 bits (282), Expect = 1e-25
Identities = 64/181 (35%), Positives = 106/181 (58%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+ GA + N G + L + +G + P D +++ R ++TL +R E+ ++
Sbjct: 208 YIAGHNDVLGGAVLWN-GEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSEN 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKK--QTSGHSGVFSFVHVGGLKESNKFLS 354
++ IA +L HPKV++V +PGL P +++ ++ + + GV +F +G + FL
Sbjct: 267 AMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAF-DLGSGDNALAFLR 325
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
LK + SLGG ES+A P ++ E R LGITD L+RLSVGLE ++LI D+
Sbjct: 326 GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
Query: 535 E 537
+
Sbjct: 386 D 386
>UniRef50_Q67KY0 Cluster: O-acetylhomoserine sulfhydrylase; n=28;
cellular organisms|Rep: O-acetylhomoserine sulfhydrylase
- Symbiobacterium thermophilum
Length = 435
Score = 117 bits (281), Expect = 2e-25
Identities = 60/150 (40%), Positives = 90/150 (60%), Gaps = 1/150 (0%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
+G SP + +L+ L TLA+RM +++L IA +L +HP V V +PGLPSHP H +
Sbjct: 277 LGGCQSPFNAFLLLLGLDTLALRMRAISENALEIARYLSEHPAVAWVRYPGLPSHPDHAL 336
Query: 271 TKKQ-TSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPA 447
++ T G G+ F GGL+ +F+ S+++F+ ++G SL P+ TH+ +
Sbjct: 337 AQRYLTGGFGGMLVFGLKGGLEAGARFIDSVRLFSHVANVGDARSLVIHPASTTHSQLTP 396
Query: 448 EQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
QR G+ D L+R+SVG ED DLIADLE
Sbjct: 397 AQREAAGVGDDLIRVSVGFEDVADLIADLE 426
>UniRef50_Q1VZU8 Cluster: Cystathionine beta-lyase; n=12;
Bacteroidetes|Rep: Cystathionine beta-lyase -
Psychroflexus torquis ATCC 700755
Length = 405
Score = 117 bits (281), Expect = 2e-25
Identities = 64/178 (35%), Positives = 102/178 (57%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+ GA + ++ +N G + + +L+ RS+KTL +R++Q ++
Sbjct: 222 YLGGHSDITAGAVASTEAIMNKVFSKAKNFGGSL-ADQTVWLLERSMKTLNLRVKQQTQN 280
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ +A +L V V +PGL S+PQH++ K Q G G+ SF + +++ KF SL
Sbjct: 281 AMDMAEFLENSSFVDKVYYPGLESNPQHQLAKDQMLGFGGMLSF-ELNEKRDTVKFFDSL 339
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+ SLGG ES P +H+ + AE+R GI +L+R SVG+EDT+DL DL
Sbjct: 340 KMIKNVLSLGGVESTVLSPEKTSHSLLTAEERHAQGIKSNLIRFSVGIEDTQDLKQDL 397
>UniRef50_Q5NQQ3 Cluster: Cystathionine beta-lyase; n=41;
Proteobacteria|Rep: Cystathionine beta-lyase - Zymomonas
mobilis
Length = 682
Score = 116 bits (280), Expect = 3e-25
Identities = 72/179 (40%), Positives = 98/179 (54%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD +MG+ I KL+ + N G SP D + L+TL +R++ H+K+
Sbjct: 494 YITGHSDTMMGSVTAIPSHID-KLKRISNLFGQYVSPDDANSALKGLRTLEVRLKAHEKN 552
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGG-LKESNKFLSS 357
+L +A WL + P+V VLHP L S P HE + G SG+FSFV GG ++ + S
Sbjct: 553 ALKVAKWLSEQPEVAWVLHPALSSCPGHEFWHRDFKGSSGLFSFVLEGGDDRDRTALIDS 612
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L+ F + S GGYESLA LP P A +VRL +GLED +DLI DL
Sbjct: 613 LEHFGIGFSWGGYESLA-LPV----DPQPIRTAASWQAAGPVVRLHIGLEDPDDLIEDL 666
>UniRef50_Q13Z52 Cluster: Cystathionine beta-lyase; n=2;
Burkholderia|Rep: Cystathionine beta-lyase -
Burkholderia xenovorans (strain LB400)
Length = 394
Score = 116 bits (280), Expect = 3e-25
Identities = 70/181 (38%), Positives = 97/181 (53%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +G DV+MGA I D + KL+ + MGI S DC L+ RSL T+ +R EQH ++
Sbjct: 212 YQSGGGDVLMGATITVDRELHLKLKAARMRMGIGVSSDDCSLILRSLPTMQLRFEQHDRA 271
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLK--ESNKFLS 354
+L +A WL P++ VLHP LP P HE ++ +G G+FS V G + + F
Sbjct: 272 ALGLARWLKTRPEIATVLHPALPDCPGHEFFERDFTGAGGLFSVVFDGRYSPAQIDTFCE 331
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
SL++F+L S GG SLA M + Q +LVR +GLE DL AD+
Sbjct: 332 SLELFSLGWSWGGAHSLA-----MPYDVASMRTAGQWPHRGTLVRFYIGLETEADLRADI 386
Query: 535 E 537
E
Sbjct: 387 E 387
>UniRef50_Q0B7N7 Cluster: Cystathionine gamma-synthase; n=4;
Betaproteobacteria|Rep: Cystathionine gamma-synthase -
Burkholderia cepacia (strain ATCC 53795 / AMMD)
Length = 389
Score = 116 bits (280), Expect = 3e-25
Identities = 64/178 (35%), Positives = 102/178 (57%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH D + G I V+A ++ +G V SPMD +L+ R L+TL +R+E+ +
Sbjct: 206 YLGGHHD-LTGGVICTSRVLAEQIWHTHITLGSVLSPMDAWLLLRGLRTLPMRVERINAN 264
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L H K++ V +PGL SHPQH + +Q G GV +F GG E+ +F+ +L
Sbjct: 265 AQALAEFLEAHAKIERVFYPGLRSHPQHGLACRQMRGFGGVVAFGVRGGYGEAQRFVEAL 324
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
++ A +LGG +SLA + M ++ AEQ I + +R SVG+E +DL D+
Sbjct: 325 RLPMNAGNLGGVDSLAIHTASMWAGTMSAEQMRAADIPLNFIRYSVGIEHIDDLKCDI 382
>UniRef50_Q6L1U0 Cluster: Cystathionine beta-lyase; n=1; Picrophilus
torridus|Rep: Cystathionine beta-lyase - Picrophilus
torridus
Length = 364
Score = 116 bits (280), Expect = 3e-25
Identities = 63/178 (35%), Positives = 103/178 (57%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++GH+DVI G A + +I ++ + ++G P +LV R +KTL +RME+ ++
Sbjct: 186 FLSGHNDVIAGVAAGSYDLIK-RIDDTRRSLGTSMDPNTAFLVERGIKTLDLRMERINEN 244
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ IA +L + P+V DV++PGL SHP H I + G+SGV F K+ N F+ L
Sbjct: 245 AMKIARFLNESPRVSDVIYPGLESHPDHGIASRLLRGYSGVILFKL---KKDFNDFIDKL 301
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
A +LGG ++ P M+H S+ ++ LGI VRLS G+E+ E++I +L
Sbjct: 302 SNIKAANTLGGLNTIVSNPYTMSHRSLNNDELKILGIDKDYVRLSAGIENPENIIEEL 359
>UniRef50_Q4QFT8 Cluster: Cystathionine beta-lyase-like protein;
n=4; Eukaryota|Rep: Cystathionine beta-lyase-like
protein - Leishmania major
Length = 459
Score = 116 bits (279), Expect = 3e-25
Identities = 69/189 (36%), Positives = 108/189 (57%), Gaps = 11/189 (5%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GHSD + G V ++ FLQNA G +P DC+L+ R ++TL+IR+E+ + +
Sbjct: 258 FLCGHSDTMCGLICVKSEEDVKRVAFLQNAQGNALAPFDCWLLLRGIRTLSIRVEKQELN 317
Query: 181 SLIIANWLLKHPKVKDVLH-PGL--PSHPQ--------HEITKKQTSGHSGVFSFVHVGG 327
++ +A +L + V LH GL + PQ + + QTSG V S + G
Sbjct: 318 AVAVALFLSRQSHVVSRLHYAGLNPATSPQISSLTEENFYLHRSQTSGPGSVLS-IETGS 376
Query: 328 LKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLE 507
+K SN F+ + K+F L S G SL E+P +++HAS+P E+R + L+RLSVG+E
Sbjct: 377 VKRSNAFVRACKLFKLTVSFGSCNSLVEMPCLLSHASIPKEKRT---LPVDLIRLSVGIE 433
Query: 508 DTEDLIADL 534
ED++ADL
Sbjct: 434 QIEDILADL 442
>UniRef50_Q46V95 Cluster: Cystathionine beta-lyase, bacterial; n=1;
Ralstonia eutropha JMP134|Rep: Cystathionine beta-lyase,
bacterial - Ralstonia eutropha (strain JMP134)
(Alcaligenes eutrophus)
Length = 418
Score = 115 bits (276), Expect = 8e-25
Identities = 73/179 (40%), Positives = 96/179 (53%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD ++G N ++ + MG P D YL R L+TLA+R+++H +S
Sbjct: 219 YIVGHSDAMLGVVTCNRETWPL-IKQTTHDMGQTAGPDDIYLALRGLRTLAVRLQRHWQS 277
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES-NKFLSS 357
L +A WL P+V+ VLHP LPSHP H + K+ +G G+FS V K S F+ +
Sbjct: 278 GLRVAQWLELQPQVEAVLHPALPSHPGHALWKRDFTGACGLFSVVLRTNSKASLAAFIDA 337
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L+ F L S GGYESL +P Q VRL VGLEDTEDLI DL
Sbjct: 338 LEHFGLGVSWGGYESLV-IPFTPGMGRTGHRWPHQ----GQAVRLHVGLEDTEDLIDDL 391
>UniRef50_Q1QM61 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1; Nitrobacter
hamburgensis X14|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Nitrobacter
hamburgensis (strain X14 / DSM 10229)
Length = 375
Score = 115 bits (276), Expect = 8e-25
Identities = 63/142 (44%), Positives = 94/142 (66%), Gaps = 2/142 (1%)
Frame = +1
Query: 70 LRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPG-L 246
++ L+ A+G P C++++RSL+TL+IR+E+ ++ I+A+ LL H KV V + G L
Sbjct: 221 VKALRGAIGTQLDPHSCWILSRSLETLSIRVEKADANARIVADCLLDHAKVAKVHYLGHL 280
Query: 247 PSH-PQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSV 423
+ P + K+Q +G FSF VGG + KFL++L+IF LA SLGG ESLA LP+
Sbjct: 281 DEYSPAGHVFKRQCTGAGSTFSFDIVGGQAAAFKFLNALQIFKLAVSLGGTESLASLPAS 340
Query: 424 MTHASVPAEQRAQLGITDSLVR 489
MTH+ VPA+ R ++GI DS +R
Sbjct: 341 MTHSGVPADIRQKIGILDSTIR 362
>UniRef50_A3UCA9 Cluster: Cystathionine gamma-synthase; n=2;
Hyphomonadaceae|Rep: Cystathionine gamma-synthase -
Oceanicaulis alexandrii HTCC2633
Length = 378
Score = 115 bits (276), Expect = 8e-25
Identities = 69/180 (38%), Positives = 97/180 (53%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVND-GVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGHSDV+MGA + +L + G +PS D +L+ R L+TL +R E+ +
Sbjct: 200 YLNGHSDVLMGAVATKEHNERWERLCTGHSLSGAIPSAFDSWLMMRGLRTLFVRYERQSR 259
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSGHSGVFSFVHVGGLKESNKFLS 354
+++ +A L +H V VL+PGL SHP H + +Q T G G+ S GG + K +
Sbjct: 260 NAMQLAQTLSQHKAVSHVLYPGLESHPGHAVAARQMTGGFGGLLSIRLKGGADAARKLCA 319
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
S ++F A S+GG ESL E + S P D LVRLS G+E EDLI DL
Sbjct: 320 STRVFLQATSIGGVESLIEHRKPIEGPSSPT--------PDDLVRLSCGIEAAEDLIDDL 371
>UniRef50_Q7M844 Cluster: O-ACETYLHOMOSERINE (THIOL)-LYASE; n=1;
Wolinella succinogenes|Rep: O-ACETYLHOMOSERINE
(THIOL)-LYASE - Wolinella succinogenes
Length = 422
Score = 114 bits (274), Expect = 1e-24
Identities = 66/162 (40%), Positives = 96/162 (59%), Gaps = 2/162 (1%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
V+ A+L L++ +G SP D +L + ++TL++RM +H S++ IA++L HPKV+ V
Sbjct: 257 VLRARLALLRD-IGATLSPFDSWLFIQGIETLSVRMREHSLSAMKIAHYLQNHPKVQAVY 315
Query: 235 HPGLPSHPQHEITKK--QTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLA 408
+PGL S H K SG+ SF VG + + K S+KIFTLA ++G +S+
Sbjct: 316 YPGLESDKNHANAVKYFDEGMFSGLLSF-EVGDFELAQKIADSVKIFTLATNIGDTKSII 374
Query: 409 ELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ TH V AE + G+T LVRLS+GLED DLI DL
Sbjct: 375 THSASTTHRQVSAEGLKKAGVTPGLVRLSIGLEDYRDLIEDL 416
>UniRef50_Q8RI67 Cluster: Cystathionine beta-lyase; n=2;
Bacteria|Rep: Cystathionine beta-lyase - Fusobacterium
nucleatum subsp. nucleatum
Length = 419
Score = 113 bits (272), Expect = 2e-24
Identities = 61/180 (33%), Positives = 104/180 (57%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+ NGHSDV+ GAA +I K+ LQ +G P +L R ++T+ +R+++ ++
Sbjct: 231 FANGHSDVVCGAATGKSELIK-KIYELQVLLGTQSDPFSSWLTVRGMRTMELRIKKQCEN 289
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGH-SGVFSFVHVGGLKESNKFLSS 357
+ +A L K P + V HP L ++P H + +Q + G+ S LK+ NKF+ +
Sbjct: 290 ASALALELEKSPYILKVNHPSLVNNPYHNLAHEQFGDYYGGMLSIELPEDLKKINKFMRT 349
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LK+ A +LGGY + P + +H+ + ++R +GITD L+R+SVG+E+ +DLI D +
Sbjct: 350 LKLAHYAMTLGGYRTSFAYPVMSSHSDMTRDERLAIGITDGLLRISVGIENIKDLINDFK 409
>UniRef50_Q67VG6 Cluster: Putative O-succinylhomoserine
(Thiol)-lyase; n=4; Oryza sativa|Rep: Putative
O-succinylhomoserine (Thiol)-lyase - Oryza sativa subsp.
japonica (Rice)
Length = 425
Score = 113 bits (271), Expect = 3e-24
Identities = 54/144 (37%), Positives = 91/144 (63%)
Frame = +1
Query: 103 PSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ 282
P ++ Y++ R LKT+A+R+E +++L +A L +HPKV+ V +P L S P H + +KQ
Sbjct: 275 PPDLEAYMIIRGLKTMALRVEAQNRTALRVARLLERHPKVERVNYPWLESSPWHGVARKQ 334
Query: 283 TSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQ 462
+G GV SF ++ + +F+ +L++ +A SLGG ESL + P++M++ ++ +
Sbjct: 335 MTGAGGVISFEVASDMRGAMRFVDALELPFIATSLGGCESLVQQPAIMSYWGKSEAEKTE 394
Query: 463 LGITDSLVRLSVGLEDTEDLIADL 534
GI D+LVR S G+E EDL D+
Sbjct: 395 NGIKDNLVRFSFGIEKFEDLKDDI 418
>UniRef50_A3X9V5 Cluster: Cystathionine gamma-synthase; n=12;
Rhodobacteraceae|Rep: Cystathionine gamma-synthase -
Roseobacter sp. MED193
Length = 390
Score = 112 bits (269), Expect = 6e-24
Identities = 67/179 (37%), Positives = 102/179 (56%), Gaps = 2/179 (1%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGV-IAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+NGHSDV+ G + + +N G V P + +L+ RS++TL +R+E+ +
Sbjct: 215 INGHSDVLGGVLSTRLRTPLWEAICMDRNEAGAVMGPFEAWLLVRSMRTLPLRVEKMCAN 274
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSG-VFSFVHVGGLKESNKFLSS 357
++ +A +L HP+V+DVL+PGLPSH H + +Q SG G + SF+ GG + +
Sbjct: 275 AMAVAEFLASHPEVEDVLYPGLPSHAGHGLASQQMSGGYGFLMSFLVKGGREAALAVAGR 334
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L +F A SLGG ESL E H P GI ++L+R+S+G+ED DLI+DL
Sbjct: 335 LNLFHRATSLGGVESLVE----HRHTIEP-----HTGIPENLLRISIGIEDANDLISDL 384
>UniRef50_Q5FUW3 Cluster: Cystathionine beta-lyase; n=3;
Acetobacteraceae|Rep: Cystathionine beta-lyase -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 405
Score = 111 bits (268), Expect = 7e-24
Identities = 68/180 (37%), Positives = 93/180 (51%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSDVIMG+ VN+ LR +G+ P DC+L R L+T+ +R+ +S
Sbjct: 222 YPAGHSDVIMGSVTVNNEAHWKTLRDAAIQLGLCAGPDDCWLTLRGLRTMGVRLAHQSRS 281
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVF--SFVHVGGLKESNKFLS 354
+L IA WL P+V VLHP L P HE K+ +G G+F ++ + + +
Sbjct: 282 TLEIAQWLKTRPEVARVLHPALEDCPGHEFWKRDFTGACGLFGVELQPEISVEAAERMID 341
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L +F + S GGYESL LP+ V E G T + RL +GLED EDL DL
Sbjct: 342 GLGMFGIGASWGGYESLV-LPTTGHIRRVTGEG----GPTSATFRLHIGLEDVEDLKTDL 396
>UniRef50_A6NZI8 Cluster: Putative uncharacterized protein; n=1;
Bacteroides capillosus ATCC 29799|Rep: Putative
uncharacterized protein - Bacteroides capillosus ATCC
29799
Length = 429
Score = 111 bits (268), Expect = 7e-24
Identities = 57/154 (37%), Positives = 91/154 (59%), Gaps = 1/154 (0%)
Frame = +1
Query: 79 LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHP 258
L +G +PSP +CY +N L+TL +RM+QH ++L +A +L H KV V +PGL
Sbjct: 270 LMRDLGSIPSPQNCYYLNIGLETLPLRMKQHCSNALAVAQYLQSHEKVAWVKYPGLEGDQ 329
Query: 259 QHEITKK-QTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHA 435
H + K +G GV SF GG + ++KF++ L++ ++A + ++ P+ TH
Sbjct: 330 YHAMAAKYMPNGTCGVVSFGVKGGREAASKFMAGLELASIATHVADAKTCVLHPASTTHR 389
Query: 436 SVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ + A G++ LVRLSVG+ED DL+AD+E
Sbjct: 390 QMNDAELAAAGVSPDLVRLSVGIEDPADLLADIE 423
>UniRef50_Q1IQD6 Cluster: Cystathionine gamma-synthase; n=2;
Acidobacteria|Rep: Cystathionine gamma-synthase -
Acidobacteria bacterium (strain Ellin345)
Length = 390
Score = 111 bits (267), Expect = 1e-23
Identities = 70/180 (38%), Positives = 100/180 (55%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVND-GVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y++GHSD + GA I+ G +A K+R Q+ G V SP DC+L+ R +++L RM H +
Sbjct: 208 YLSGHSDAMGGAVILKRAGDLAHKIRDFQHNGGAVLSPFDCWLILRGIESLPARMRIHCE 267
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++ IA +L H V V +PGL + P H I K+Q G+ SF G E+ S
Sbjct: 268 NAQKIAEFLSAHAAVSKVRYPGLTNDPGHAIAKRQMRAFGGMLSFEIRGARAEAFLVSSR 327
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ A SLGG +L E AS+ + A +SL+R+SVGLEDT DLI DL+
Sbjct: 328 FQLIIRATSLGGTHTLVE-----HRASI---EGAHTRAPESLLRMSVGLEDTADLIDDLD 379
>UniRef50_A6W2A4 Cluster: Cystathionine beta-lyase; n=1; Marinomonas
sp. MWYL1|Rep: Cystathionine beta-lyase - Marinomonas
sp. MWYL1
Length = 388
Score = 111 bits (267), Expect = 1e-23
Identities = 62/177 (35%), Positives = 103/177 (58%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+MGAA+V + LR L + G SP + Y R ++TL +R+++H ++
Sbjct: 209 YLGGHADVMMGAAVVKKHAMNP-LRSLVHITGQTLSPDEAYACLRGMRTLDLRLQRHGEN 267
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
SL +A WLL+ +VK +LHPGL HP ++I ++ G +G+ S V + K L +L
Sbjct: 268 SLAVAKWLLQRAEVKSILHPGLQDHPGYKIWQRDAIGCNGLLS-VEFNENIDVEKLLDNL 326
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
++F++ S GG+ESLA LP + + ++VR +G+E +D++AD
Sbjct: 327 RLFSIGTSWGGFESLA-LPIDPQKERIFNNEFTSY----NMVRFHIGIEHIDDILAD 378
>UniRef50_Q0C2A8 Cluster: Cystathionine beta-lyase; n=1; Hyphomonas
neptunium ATCC 15444|Rep: Cystathionine beta-lyase -
Hyphomonas neptunium (strain ATCC 15444)
Length = 389
Score = 110 bits (265), Expect = 2e-23
Identities = 67/182 (36%), Positives = 97/182 (53%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD GA + N+ +A K+ GI +P D YL R +++L R++ H+ +
Sbjct: 204 YVVGHSDAFGGAVMTNELSLANKVANCSEDWGIGLAPDDAYLAVRGIRSLTTRLKAHEAA 263
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV---HVGGLKESNKFL 351
L +A WL P+V V+HP LPSHP H + K+ +G G+FSFV + G E +F
Sbjct: 264 GLELAQWLEGRPEVASVIHPALPSHPDHALWKRDFTGACGLFSFVLKDYPAGALE--RFF 321
Query: 352 SSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
+L +F + S GG+ESL S + + G L+R+ VGLE DL AD
Sbjct: 322 EALSLFGMGFSWGGFESLIIPCDDQLTRSETCWTKDKPG---QLMRVHVGLEAVSDLKAD 378
Query: 532 LE 537
LE
Sbjct: 379 LE 380
>UniRef50_A0LY60 Cluster: O-succinylhomoserine sulfhydrylase; n=13;
Bacteria|Rep: O-succinylhomoserine sulfhydrylase -
Gramella forsetii (strain KT0803)
Length = 404
Score = 110 bits (265), Expect = 2e-23
Identities = 55/178 (30%), Positives = 107/178 (60%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
++G V+ G + + +I F +N G SP + +++++SL+TLA+R+++H +++
Sbjct: 224 IDGQGRVLGGVTVGREDLIREIYLFSRNT-GPALSPFNAWVLSKSLETLAVRLDRHCENA 282
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
L +A +L + ++ V +P L SHPQ++I K+Q V +F GG++ KF+ L
Sbjct: 283 LKVAEFLEANKNIEQVKYPFLKSHPQYDIAKRQMKLGGNVVAFQIKGGVEAGRKFIDKLL 342
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ + + +LG ++ P+ TH+ + ++ + GI + LVR+SVGLE+ +D+I DL+
Sbjct: 343 LCSRSANLGDTRTIVTHPASTTHSKLSHDELSSAGIAEGLVRVSVGLENVDDVIKDLK 400
>UniRef50_Q89VE2 Cluster: O-succinylhomoserine sulfhydrylase; n=72;
cellular organisms|Rep: O-succinylhomoserine
sulfhydrylase - Bradyrhizobium japonicum
Length = 417
Score = 110 bits (264), Expect = 2e-23
Identities = 56/178 (31%), Positives = 95/178 (53%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++G + G + ++ +A L G SP + +++ + L+TLA+R+ +
Sbjct: 233 HIDGQGRCLGGIILSSEAFVAEHLHNFMRQTGPSISPFNAWVLLKGLETLAVRVRAQTDT 292
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A L HPK+ +++PG HPQ + KKQ G S + F GG + + L+ L
Sbjct: 293 AASVAEVLAGHPKISRLIYPGRADHPQAALVKKQMRGGSTLVGFEVKGGKAAAFRVLNEL 352
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+ ++ +LG +SL P+ TH + E RA LGI++ +R S GLE +DLI DL
Sbjct: 353 KLAKISNNLGDAKSLVTHPATTTHQRLKPEDRAALGISEGFIRFSAGLEHADDLIEDL 410
>UniRef50_Q493X0 Cluster: Beta-cystathionase; n=2;
Enterobacteriaceae|Rep: Beta-cystathionase - Blochmannia
pennsylvanicus (strain BPEN)
Length = 395
Score = 109 bits (262), Expect = 4e-23
Identities = 67/181 (37%), Positives = 101/181 (55%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD ++G A+ N +L+ MG + Y+ +R L+TL +R++QH+++
Sbjct: 210 YIIGHSDGMIGTAVSN-ARCWDQLQEQSYLMGQMVDADTAYMASRGLRTLYVRLKQHEEN 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV---HVGGLKESNKFL 351
L +A+WL +HPK++ V HP L + H+ + SG SG+FSF+ + L+ SN F+
Sbjct: 269 GLHVAHWLAQHPKIERVNHPALSTCKGHKYFIRDFSGSSGLFSFILKNRLNDLQLSN-FI 327
Query: 352 SSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
K F +A S GG+ESL + V P L T +LVR+ VGLE DLI D
Sbjct: 328 DHFKYFKIAYSWGGFESLILVNQV--EELRPIRPSGALDFTGTLVRIHVGLEHPNDLIHD 385
Query: 532 L 534
L
Sbjct: 386 L 386
>UniRef50_P53101 Cluster: Cystathionine beta-lyase; n=5;
Saccharomycetales|Rep: Cystathionine beta-lyase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 465
Score = 109 bits (262), Expect = 4e-23
Identities = 67/188 (35%), Positives = 101/188 (53%), Gaps = 10/188 (5%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGH D++ G I IA+KL F+ N+ G SPMD +L+ R LKTL +R+ Q +++
Sbjct: 214 YLNGHHDLMGGVIISKTPEIASKLYFVINSTGAGLSPMDSWLLVRGLKTLGVRLYQQQRN 273
Query: 181 SLIIANWL--------LKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKE 336
++I+A+WL + K GL S+P ++ K +G V SF G +
Sbjct: 274 AMILAHWLENSCGFKPTRTNKATKTRFVGLRSNPDFKLHKSFNNGPGAVLSF-ETGSFEH 332
Query: 337 SNKFLSS--LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLED 510
S + +SS L I+ + S G SL +P M+HAS+ E R + + LVRL G+E+
Sbjct: 333 SKRLVSSKKLSIWAVTVSFGCVNSLLSMPCKMSHASIDPELRKERDFPEDLVRLCCGIEN 392
Query: 511 TEDLIADL 534
DL DL
Sbjct: 393 IVDLKKDL 400
>UniRef50_Q6MN74 Cluster: Cys/Met metabolism lyase; n=1;
Bdellovibrio bacteriovorus|Rep: Cys/Met metabolism lyase
- Bdellovibrio bacteriovorus
Length = 426
Score = 109 bits (261), Expect = 5e-23
Identities = 64/181 (35%), Positives = 97/181 (53%), Gaps = 11/181 (6%)
Frame = +1
Query: 28 MGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCY-LVNRSLKTLAIRMEQHKKSSLIIANWL 204
MG A++ + LR + G + P + ++ + T AIR EQ + S+ +A +L
Sbjct: 240 MGGAVIAPRTHESILRVARKDFGAIIHPYSAWHILVYGISTQAIRFEQQQASAWAVAKFL 299
Query: 205 LKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVF------SFVHVGGLKESNKFLSSLK- 363
HPKV V +PGL SH QH++ KK G F SF G +K+ KF+ +
Sbjct: 300 EAHPKVASVTYPGLKSHAQHKLAKKYLKSPEGKFAPGTMISFQLKGDMKKCQKFVDDIAK 359
Query: 364 ---IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
TLA SLG ++L E+P MTH+++P ++R GI +RLS+GLE+ D+I DL
Sbjct: 360 NSYSITLAVSLGLTKTLIEVPGFMTHSAIPDDKRGDSGIDPRAIRLSIGLENVNDIIEDL 419
Query: 535 E 537
+
Sbjct: 420 K 420
>UniRef50_A4AA77 Cluster: Cystathionine beta-lyase; n=2;
Bacteria|Rep: Cystathionine beta-lyase - Congregibacter
litoralis KT71
Length = 439
Score = 109 bits (261), Expect = 5e-23
Identities = 69/181 (38%), Positives = 99/181 (54%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+NGH+D + G + + +L A G+ +P D L R L+TLA+RM H +
Sbjct: 252 YLNGHADCLFGVTTMRSPELYTQLHHHTLAHGMHLAPDDANLALRGLRTLAVRMGVHDQG 311
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES-NKFLSS 357
+ +A WL K P+V+ +LHP S P H I ++ G +G+F V +E+ F+ +
Sbjct: 312 ARCVAAWLEKQPRVRRLLHPAWESCPGHAIFERDFQGANGLFGMVMRRETEEALAAFVDA 371
Query: 358 LKIFTLAESLGGYESLAELPSVMTH--ASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
L++F + S GG+ESL LP T ASVP L + LVRL +GLE EDLIAD
Sbjct: 372 LQLFGVGFSWGGFESLC-LPMQATRNLASVP------LAHDEGLVRLHIGLEHPEDLIAD 424
Query: 532 L 534
L
Sbjct: 425 L 425
>UniRef50_A3SR24 Cluster: Cystathionine gamma-synthase; n=3;
Alphaproteobacteria|Rep: Cystathionine gamma-synthase -
Roseovarius nubinhibens ISM
Length = 386
Score = 109 bits (261), Expect = 5e-23
Identities = 68/181 (37%), Positives = 101/181 (55%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIV-NDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGHSDV GA V N ++ + G V D +L+ R ++TL +R E+
Sbjct: 206 YLNGHSDVTAGALSVRNMDAWWEEIEGHRKLQGTVLQSFDAFLLIRGMRTLTLRYERATL 265
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSG-HSGVFSFVHVGGLKESNKFLS 354
++L IA HP+V+ VL+PGL SHP H+I K+QT G + G+ S + G + +
Sbjct: 266 NALRIATHFEGHPQVRKVLYPGLESHPDHDIAKRQTHGMYGGMMSIIVKGDEQAAIDVAR 325
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
++F A SLGG ESL E H + + + + +L+RLS+G+ED +DLIADL
Sbjct: 326 FCQLFYPATSLGGVESLIE------HRKTVSGEGFK--VHPALLRLSIGIEDADDLIADL 377
Query: 535 E 537
E
Sbjct: 378 E 378
>UniRef50_A0H5P3 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=3; Chloroflexi
(class)|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Chloroflexus
aggregans DSM 9485
Length = 373
Score = 109 bits (261), Expect = 5e-23
Identities = 60/179 (33%), Positives = 96/179 (53%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GHSD++ G D + +L + G +P ++ +L R +TLA+R+E+ + +
Sbjct: 196 FIGGHSDLLAGVVTTRDEALWQQLHQTRTLAGAIPGTLEAFLAVRGARTLALRLERAQYN 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++I+A LL+HP V V +PGLPSHP H K+ G + SF GG ++ +
Sbjct: 256 AMILAQRLLEHPLVTCVRYPGLPSHPTHTTAKRLLKGFGTIISFDVAGGAATADAVCRHV 315
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ A SLG ES E A+V ++ + SL+RLSVG+ED DL DL+
Sbjct: 316 RLIRHATSLGAVESTME-----RRAAVAGQEH----LPPSLLRLSVGIEDVHDLWNDLD 365
>UniRef50_Q11FS5 Cluster: Cystathionine beta-lyase; n=5;
Alphaproteobacteria|Rep: Cystathionine beta-lyase -
Mesorhizobium sp. (strain BNC1)
Length = 398
Score = 108 bits (260), Expect = 7e-23
Identities = 73/180 (40%), Positives = 95/180 (52%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YM GHSD++MGA V D + +LR +G SP DC LV R L+TLA+R+ Q S
Sbjct: 216 YMAGHSDLLMGAVTVRDLALFDRLRTAFKLLGHGVSPDDCSLVLRGLETLAVRLRQSSAS 275
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV-HVGGLKESNKFLSS 357
+L +A L + + + VLHP LPS H I K+ G SGVFS V L LS
Sbjct: 276 ALDLARMLEESGRFQAVLHPALPSFSGHAIWKRDFKGASGVFSVVLKPESLDRLPNALSR 335
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L++F + S GG SL P +T A + I +RLSVG+E DL ADL+
Sbjct: 336 LRVFAIGASWGGTHSLV-APMDITAARTATACPWRCPI----IRLSVGMEGLADLRADLQ 390
>UniRef50_A7S3X8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 343
Score = 108 bits (260), Expect = 7e-23
Identities = 58/108 (53%), Positives = 73/108 (67%), Gaps = 2/108 (1%)
Frame = +1
Query: 217 KVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGY 396
KV V +PGLPS+P H I KKQ G SG+ SF GGL+E+ KF SLK+ LA SLGG
Sbjct: 228 KVSVVNYPGLPSNPGHLIAKKQMRGFSGMVSFEVKGGLQEAVKFAESLKLVKLAVSLGGT 287
Query: 397 ESLAELPSVMTHAS--VPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+SL E+ S MTH V E +A+ G++DSL+R+SVGLE EDL D+
Sbjct: 288 DSLVEVVSCMTHPDKYVTPEMKAEAGVSDSLIRISVGLEHVEDLKQDI 335
>UniRef50_Q62JZ5 Cluster: Cystathionine beta-lyase; n=37;
Burkholderiales|Rep: Cystathionine beta-lyase -
Burkholderia mallei (Pseudomonas mallei)
Length = 394
Score = 108 bits (259), Expect = 9e-23
Identities = 67/181 (37%), Positives = 99/181 (54%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +G SDV+MGA I DG + AKL+ + +GI S DC LV R L ++ R + H +S
Sbjct: 212 YQSGGSDVLMGATITADGELHAKLKLARMRLGIGVSADDCSLVLRGLPSMQARFDAHSRS 271
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFS--FVHVGGLKESNKFLS 354
+L +A WL ++ VLHP LP P H+ + +G G+FS F + ++F+
Sbjct: 272 ALSLARWLKTRAEIATVLHPQLPDCPGHDTFMRDFTGAGGLFSVVFDERYDAAQVDRFVE 331
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L++F + S GG SLA +P V + + + +LVR VGLED DL AD+
Sbjct: 332 ALELFAIGWSWGGACSLA-MP-----YDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADI 385
Query: 535 E 537
E
Sbjct: 386 E 386
>UniRef50_Q5PBE9 Cluster: Cystathionine beta-lyase; n=1; Anaplasma
marginale str. St. Maries|Rep: Cystathionine beta-lyase
- Anaplasma marginale (strain St. Maries)
Length = 408
Score = 108 bits (259), Expect = 9e-23
Identities = 68/183 (37%), Positives = 102/183 (55%), Gaps = 4/183 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSDV+MGA IVND I +L GI S DCYLV R +KT+ +RM+Q + +
Sbjct: 225 YFGGHSDVMMGALIVNDEGIFDRLYVDHRNYGIYVSSDDCYLVQRGMKTMRVRMQQVQST 284
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGV----FSFVHVGGLKESNKF 348
++ +A+ L H K+ V++PGLPS+P E+ +K G G+ F ++E ++
Sbjct: 285 AIALASRLQAHKKISQVIYPGLPSYPHREVWEKYCRGKYGLGLVNLMFDGNYSVEEVDRA 344
Query: 349 LSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIA 528
L + F + S GG S+ +P V + + A Q GI D L R+ GLED E++I+
Sbjct: 345 LEGIDTFKIGLSWGGCRSIV-IPIVSKGSLINA---PQAGI-DGL-RVYCGLEDPEEIIS 398
Query: 529 DLE 537
+E
Sbjct: 399 SVE 401
>UniRef50_O94350 Cluster: Cystathionine beta-lyase; n=27; cellular
organisms|Rep: Cystathionine beta-lyase -
Schizosaccharomyces pombe (Fission yeast)
Length = 390
Score = 108 bits (259), Expect = 9e-23
Identities = 61/180 (33%), Positives = 101/180 (56%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GH D++ G IA + F NAMG +P +C+L+ R +KT+ +R+E+ +++
Sbjct: 203 YLSGHHDLMGGVIATKSDEIAKSVFFNINAMGAAMAPFECFLLLRGIKTMGLRVERAQQN 262
Query: 181 SLIIANWLLKHPKVKDVLHPGL-PSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++ IA +L K V PGL P I G V S V G ++ S +++
Sbjct: 263 AIEIAKFLKS--KGLQVNFPGLDPDAKSTAIFYSFARGPGAVMS-VFTGDVEVSKTIVNT 319
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+F ++ S G SL +P+ M+HAS+ E R G+++ L+R+ VG+E+ +DL ADLE
Sbjct: 320 TKLFEISVSFGAVNSLISMPAYMSHASIKKEVRDARGLSEDLIRICVGIENVDDLKADLE 379
>UniRef50_Q49UL2 Cluster: Cystathionine beta-lyase cystathionine
gamma-synthase; n=16; Staphylococcus|Rep: Cystathionine
beta-lyase cystathionine gamma-synthase - Staphylococcus
saprophyticus subsp. saprophyticus (strain ATCC 15305
/DSM 20229)
Length = 391
Score = 107 bits (258), Expect = 1e-22
Identities = 61/178 (34%), Positives = 98/178 (55%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++GH+D+I G AI ND IA L LQN G S D + + + LKTL +R Q ++
Sbjct: 197 FLSGHTDIIAGVAITNDQTIADALYLLQNGTGTALSAQDSWTLAKHLKTLPVRFNQSVEN 256
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ + +L + ++ +V +PG ++ Q S H G + ++ F+ +L
Sbjct: 257 TKKLYEYLAQRDEIAEVYYPG-----NSDLHLSQAS-HGGAVLGFRLKDETKAQDFVDAL 310
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ ++ SLGG E++ P+ M+HA+VP E R IT L RLSVGLE ++LI+DL
Sbjct: 311 SLPLVSVSLGGVETILSHPATMSHAAVPKEVREARNITFGLFRLSVGLETADELISDL 368
>UniRef50_O69592 Cluster: O-succinylhomoserine sulfhydrylase; n=19;
Bacteria|Rep: O-succinylhomoserine sulfhydrylase -
Mycobacterium leprae
Length = 426
Score = 107 bits (257), Expect = 2e-22
Identities = 60/183 (32%), Positives = 103/183 (56%), Gaps = 4/183 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++G V+ GA + + I ++ L G S + +++ + L+TLAIR++ S
Sbjct: 240 HIDGQGRVLGGAILGDRDYIDGPVQKLMRHTGPAMSAFNAWILLKGLETLAIRVDHCNSS 299
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV----HVGGLKESNKF 348
+ IA +L KHP V V +P L SHPQ+++ K+Q SG V +F + + +
Sbjct: 300 AHRIAEFLEKHPAVSWVRYPFLVSHPQYDLAKRQMSGGGTVVTFALNSPEDAAKQRAFEV 359
Query: 349 LSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIA 528
L L++ ++ + G +SL P+ TH ++ E RA +G+ D +VR+S+GLED DLIA
Sbjct: 360 LDRLRLIDISNNFGDVKSLITHPATTTHRAMGPEGRAAIGLGDGVVRISIGLEDAADLIA 419
Query: 529 DLE 537
D++
Sbjct: 420 DID 422
>UniRef50_A5WGJ5 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=142; Bacteria|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Psychrobacter sp. PRwf-1
Length = 437
Score = 107 bits (257), Expect = 2e-22
Identities = 53/161 (32%), Positives = 96/161 (59%), Gaps = 1/161 (0%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
+ A++ L+N G SP++ + + + ++TL++RME+H +++ +A +L H KV V
Sbjct: 271 IARARVAPLRNT-GAALSPLNAFSILQGIQTLSLRMERHVQNAQAVAEYLKAHDKVAWVK 329
Query: 235 HPGLPSHPQHEITKKQTSGH-SGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAE 411
+ GL HP H++ +K G S + +F GG + KF+ +L + T ++G +SLA
Sbjct: 330 YAGLADHPDHQLAQKYMKGTPSAILTFGVKGGREAGAKFIDALNLITRLVNIGDAKSLAS 389
Query: 412 LPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
P+ TH + E+ A G+++ ++RLS+G+E ED+ ADL
Sbjct: 390 HPATTTHRQLNDEELANAGVSEDMIRLSIGIEHIEDIKADL 430
>UniRef50_Q1GQF1 Cluster: Cystathionine beta-lyase; n=1;
Sphingopyxis alaskensis|Rep: Cystathionine beta-lyase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 415
Score = 107 bits (256), Expect = 2e-22
Identities = 60/180 (33%), Positives = 98/180 (54%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSD ++G + +L+ G SP +CYLV+R ++TL R+E+H+++
Sbjct: 225 YLSGHSDCLLGTMTAASDAVYRQLKDAAARWGNCASPDNCYLVHRGIRTLDARLERHQRT 284
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGL--KESNKFLS 354
+ + W + P+V V +P P+ P H I K+ +G SG+F V + GL +++ F +
Sbjct: 285 AATLIEWFAQQPEVVAVRYPAHPADPGHAIWKRDFTGASGLFG-VQLDGLTPPQTSAFFN 343
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+F L S GG+ESLA +P+ P +L+R+ GLE +DLIADL
Sbjct: 344 EFSLFQLGSSWGGFESLA-VPA----WPAPIRDFPNGEADGALIRIHAGLEAPQDLIADL 398
>UniRef50_A6GRN0 Cluster: Cystathionine beta-lyase; n=1; Limnobacter
sp. MED105|Rep: Cystathionine beta-lyase - Limnobacter
sp. MED105
Length = 402
Score = 106 bits (255), Expect = 3e-22
Identities = 66/180 (36%), Positives = 94/180 (52%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GH+DV+MGA + N+ A L +G+ SP DC LV R L TL +R Q K+
Sbjct: 215 YQCGHADVLMGAVLSNNTKAFADLERKNRILGLGVSPADCDLVLRGLLTLHLRYRQQAKN 274
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGL--KESNKFLS 354
L +A L HP V VLHP P P H K+ +G + +FS V +++ +
Sbjct: 275 GLQVATALKAHPAVARVLHPEFPECPGHTFYKRDFNGFASIFSVVLKSEYTDEQACAIID 334
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L++F +A S GG ESL + +V S +G ++RL++GLE+ DLIADL
Sbjct: 335 RLRLFKIAYSWGGPESLGLVVNVPD--SRRRHLTDSMGTCGPILRLAIGLEEPADLIADL 392
>UniRef50_Q5QWY7 Cluster: Cystathionine gamma-synthase; n=5;
Proteobacteria|Rep: Cystathionine gamma-synthase -
Idiomarina loihiensis
Length = 383
Score = 106 bits (254), Expect = 4e-22
Identities = 68/181 (37%), Positives = 99/181 (54%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGA-AIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGHSDVI GA A D +L ++ G VP P D + R ++TL +R+ + +
Sbjct: 203 YLNGHSDVISGALAAREDNAFWQRLVAIRAQSGAVPGPQDAAQLLRGMRTLFLRVRESCQ 262
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSGHSGVFSFVHVGGLKESNKFLS 354
S+L IA L +HP+V +VL+PGL S HEI KQ G G+ S GG K + +
Sbjct: 263 SALYIAEQLEQHPQVIEVLYPGLKSFVGHEIAVKQMQGGFGGMLSIRLAGGEKAAIAVAA 322
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+++ A SLGG ESL E + + P + L+RLSVG+E+ +DL+ DL
Sbjct: 323 KTQLWHRATSLGGVESLIEHRASIEGPDTP--------VPLDLLRLSVGIENADDLLNDL 374
Query: 535 E 537
+
Sbjct: 375 Q 375
>UniRef50_Q8FRS9 Cluster: O-acetylhomoserine sulfhydrylase; n=8;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Corynebacterium efficiens
Length = 438
Score = 105 bits (253), Expect = 5e-22
Identities = 57/161 (35%), Positives = 94/161 (58%), Gaps = 1/161 (0%)
Frame = +1
Query: 58 IAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLH 237
+ A++ L++ G PSP + ++ N+ L TL++R+E+H ++++ +A +L H KV V
Sbjct: 273 LKARVGLLRDT-GAAPSPFNAWVTNQGLDTLSLRLERHNENAIKVAEFLNNHEKVTKVHF 331
Query: 238 PGLPSHPQHEITKKQTSGHSG-VFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAEL 414
GLP P + +K ++G V +F GG E+ F+ +LK+ + ++G SL
Sbjct: 332 AGLPDSPWYATKEKLGLKYTGSVLTFELAGGKDEAWAFIDALKLHSNLANIGDVRSLVVH 391
Query: 415 PSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
P+ TH+ A+ GIT VRLSVG+E+ ED+IADLE
Sbjct: 392 PATTTHSQSDEAGLARAGITQGTVRLSVGIENVEDIIADLE 432
>UniRef50_A0L907 Cluster: Cystathionine gamma-synthase; n=1;
Magnetococcus sp. MC-1|Rep: Cystathionine gamma-synthase
- Magnetococcus sp. (strain MC-1)
Length = 396
Score = 105 bits (253), Expect = 5e-22
Identities = 56/179 (31%), Positives = 99/179 (55%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++G V+ G + + +I +R G SP + +++ + L+TL +R+E+H +
Sbjct: 211 YLDGQGRVLGGGIVGDVELIEGPMRTYMRNAGPALSPFNAWVLYKGLETLGLRVERHCAN 270
Query: 181 SLIIANWLLKHPKVKD-VLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
++ +A L + V +PGL SHPQH + +Q G GV + + + F+
Sbjct: 271 AMQVAQALFERADTTHKVRYPGLESHPQHGLACQQMRGFGGVLC-LDLEDRARAYAFMDR 329
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L++ T+ +LG ++L P+ THA VP ++R + GI + LVR S+GLED +D++ DL
Sbjct: 330 LQLATITANLGDSKTLVTHPASTTHARVPQKERIEAGIGEGLVRFSIGLEDAQDIVDDL 388
>UniRef50_Q9X0Z7 Cluster: Cystathionine gamma-synthase; n=2;
Thermotoga|Rep: Cystathionine gamma-synthase -
Thermotoga maritima
Length = 379
Score = 105 bits (252), Expect = 6e-22
Identities = 62/182 (34%), Positives = 108/182 (59%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVP--SPMDCYLVNRSLKTLAIRMEQHK 174
Y++GH DV+ G ++ V K F+ I P SP++ +L+ R L+TL +RM++H
Sbjct: 203 YISGHGDVMAG--VIAGDVEDMKNIFVDEYKNIGPVLSPIEAWLILRGLRTLELRMKKHY 260
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFL 351
+++L+++++L+ HPKV +V +P P PQ+E+ Q SG SG+ SF + ++ +F+
Sbjct: 261 ENALVVSDFLMDHPKVLEVNYPMNPRSPQYELASSQMSGGSGLMSFRLKTDSAEKVKEFV 320
Query: 352 SSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
SL++F +A S G +E+L +P V + P + +L+R+ VGL D E L+ D
Sbjct: 321 ESLRVFRMAVSWGSHENLV-VPRV-AYGDCPKKD-------VNLIRIHVGLGDPEKLVED 371
Query: 532 LE 537
L+
Sbjct: 372 LD 373
>UniRef50_A6LZ85 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=2; Clostridium|Rep:
O-acetylhomoserine aminocarboxypropyltransferase -
Clostridium beijerinckii NCIMB 8052
Length = 434
Score = 105 bits (251), Expect = 9e-22
Identities = 54/158 (34%), Positives = 92/158 (58%), Gaps = 1/158 (0%)
Frame = +1
Query: 67 KLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGL 246
++R+L + +G SP + + + ++TL++RM +H ++ +A +L HPKV V +PGL
Sbjct: 270 RIRYLTD-LGAHLSPTSAFYLLQGIETLSLRMREHAANAQKVAEFLEGHPKVLSVAYPGL 328
Query: 247 PSHPQHEITKKQ-TSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSV 423
S+ HE+ KK G + S GG++ + K L +K+F ++G +SL +
Sbjct: 329 KSNKYHELAKKYFPKGPGAIMSIRLKGGIEAARKVLEEVKVFDYMVNVGDTKSLIVHSAT 388
Query: 424 MTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
TH E+R + G+ D +RLS+G+E+ EDLIADL+
Sbjct: 389 STHFGQSKEEREKAGVYDDTLRLSIGIEEAEDLIADLK 426
>UniRef50_A2Y9X5 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (indica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. indica
(Rice)
Length = 408
Score = 105 bits (251), Expect = 9e-22
Identities = 52/116 (44%), Positives = 70/116 (60%)
Frame = +1
Query: 190 IANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIF 369
IA +L HP+VK V + GLP HP + Q G V SF+ G L S + + K F
Sbjct: 286 IAEFLASHPRVKKVNYAGLPDHPGRSLHYSQAKGAGSVLSFL-TGSLALSKHVVETTKYF 344
Query: 370 TLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ S G +SL LP M+HAS+P+ R + G+TD LVR+SVG+ED +DLIADL+
Sbjct: 345 NVTVSFGSVKSLISLPCFMSHASIPSAVREERGLTDDLVRISVGIEDADDLIADLD 400
>UniRef50_A5CMC2 Cluster: O-acetylhomoserine (Thiol)-lyase; n=2;
Actinomycetales|Rep: O-acetylhomoserine (Thiol)-lyase -
Clavibacter michiganensis subsp. michiganensis (strain
NCPPB 382)
Length = 453
Score = 104 bits (250), Expect = 1e-21
Identities = 52/162 (32%), Positives = 89/162 (54%), Gaps = 1/162 (0%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
++A + + G P+P +L+ + ++TL++R+E+H ++L +A +L P+V V
Sbjct: 281 LVAYAREVVASRFGPTPAPFSSFLLRQGIETLSLRVERHSANALAVARFLEARPEVSSVD 340
Query: 235 HPGLPSHPQHEITKKQT-SGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAE 411
+ GL S P H++ + G VFSF GG + F ++++F+ LG SL
Sbjct: 341 YAGLESSPSHDLALRYLPDGQGSVFSFTLAGGEPAAEAFTDAVRLFSRMTHLGDVRSLVL 400
Query: 412 LPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
P+ THA E+R GI L+R+S+G+ED D++ DLE
Sbjct: 401 HPASTTHAGRTPEERDAAGIWPGLLRVSIGIEDIADILRDLE 442
>UniRef50_Q399B4 Cluster: Cystathionine beta-lyase; n=15;
Proteobacteria|Rep: Cystathionine beta-lyase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 393
Score = 104 bits (249), Expect = 1e-21
Identities = 61/181 (33%), Positives = 99/181 (54%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+MGA + + + RF + +G+ S D YL R L+TL++R+E+H+++
Sbjct: 206 YIAGHSDVLMGAILTTEALAPKVTRFYRQ-LGMTVSGDDAYLALRGLRTLSVRLERHQRN 264
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV-HVGGLKESNKFLSS 357
+ ++ +WL + P+V +L+P H + ++ +G G+F V H G + L
Sbjct: 265 AHVLTDWLSQQPEVARILYPARAGDAGHALWQRDFTGACGLFGVVLHPQGDEAVRALLDG 324
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQR--AQLGITDSLVRLSVGLEDTEDLIAD 531
+ F + S GG+ESL +P S PA R Q T L+R+ GLE +D+IAD
Sbjct: 325 MTCFGMGYSWGGFESLI-IP------SNPARNRTATQWAATGPLLRIHAGLEHPDDMIAD 377
Query: 532 L 534
L
Sbjct: 378 L 378
>UniRef50_A5WG79 Cluster: O-succinylhomoserine sulfhydrylase; n=6;
Proteobacteria|Rep: O-succinylhomoserine sulfhydrylase -
Psychrobacter sp. PRwf-1
Length = 434
Score = 103 bits (248), Expect = 2e-21
Identities = 62/186 (33%), Positives = 102/186 (54%), Gaps = 8/186 (4%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++G V+ GA + +D ++ +++ GI SP + ++ + L+TL +RM+ H +
Sbjct: 242 YIDGQGRVLGGALVGSDELMQQAFVVVRSG-GISMSPFNAWVFIKGLETLNLRMQAHCDN 300
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ---TSGHSGVFSF-VHVGGLKESNK- 345
+ IA +L HP V+ V GL SHP HE+ KQ + + F V G +
Sbjct: 301 ANKIAAFLQSHPHVEKVHFSGLTSHPMHELAVKQHHRANCFGAIMGFEVKAVGAHTAQSA 360
Query: 346 ---FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTE 516
+ S ++ ++ +LG ++ P+ TH + AE RA+ G+TDSL+RLSVGLED +
Sbjct: 361 AWHVIDSTRMVSITNNLGDAKTTVTHPATTTHFRISAEARAEAGVTDSLIRLSVGLEDVD 420
Query: 517 DLIADL 534
D+I DL
Sbjct: 421 DIIKDL 426
>UniRef50_Q9RSD8 Cluster: O-acetylhomoserine
(Thiol)-lyase/O-acetylserine (Thiol)-lyase; n=2;
Deinococcus|Rep: O-acetylhomoserine
(Thiol)-lyase/O-acetylserine (Thiol)-lyase - Deinococcus
radiodurans
Length = 418
Score = 103 bits (247), Expect = 3e-21
Identities = 52/154 (33%), Positives = 85/154 (55%)
Frame = +1
Query: 76 FLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSH 255
F + +G+ +P +L+ + L+TL +R+++ S+L +A WL +HP+V V + GLP H
Sbjct: 264 FGAHQLGMTLAPHSAFLIAQGLETLGLRLQRESDSALALARWLGQHPRVGGVSYAGLPGH 323
Query: 256 PQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHA 435
P + +K +G V + ++FLS L++ +A +LG +L P TH
Sbjct: 324 PSFPLVQKYLPRGAGAVLTFEVD---DPSRFLSRLRVLRMAPNLGDVRTLVVHPWTTTHG 380
Query: 436 SVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
VP R G+T +R+SVG+ED DL AD+E
Sbjct: 381 RVPEAARHAAGVTPGTIRMSVGVEDVMDLQADIE 414
>UniRef50_Q2S2T9 Cluster: Cystathionine beta-lyase MetC; n=1;
Salinibacter ruber DSM 13855|Rep: Cystathionine
beta-lyase MetC - Salinibacter ruber (strain DSM 13855)
Length = 382
Score = 103 bits (247), Expect = 3e-21
Identities = 61/177 (34%), Positives = 91/177 (51%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV G + L+ + G++ P C L++RSLKTL +R+ + ++
Sbjct: 197 YLGGHSDVAAGVVAGAPKPLDNALQTTKLLGGML-DPHACGLLHRSLKTLGVRVRKQNET 255
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A L H V+ V HP L SHP H+ + G G+ + + + F +L
Sbjct: 256 ARALAAALADHDGVERVHHPSLSSHPHHDRARTLLDGFGGMVG-LELASQTTVDSFFDAL 314
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
+ A SLGG E+L P +H V R +GITD VR+SVGLE +DL+AD
Sbjct: 315 SLPLRAPSLGGVETLVTQPVHTSHKDVAPAARRAMGITDRFVRVSVGLEGPKDLVAD 371
>UniRef50_A3VUE2 Cluster: Cystathionine beta-lyase; n=1;
Parvularcula bermudensis HTCC2503|Rep: Cystathionine
beta-lyase - Parvularcula bermudensis HTCC2503
Length = 381
Score = 103 bits (247), Expect = 3e-21
Identities = 65/181 (35%), Positives = 102/181 (56%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+++GA + ++AK+R + +GI S D + +R L+TL R+ H+++
Sbjct: 199 YVGGHSDLLLGA-VATAPRLSAKVRRMARMLGISVSGRDVAMAHRGLRTLHRRLAVHEEN 257
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV-HVGGLKESNKFLSS 357
L +A +L H ++ VLHPGL SHPQ + + SG +G+FS + + +F+
Sbjct: 258 GLGLARFLETHSAIRRVLHPGLDSHPQAALWARDASGTNGLFSVIADWEDEAVTARFIDH 317
Query: 358 LKIFTLAESLGGYESLAELPSVMT--HASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
L +F L S GGYESL LP+ T +VP + Q ++R GLED +DLI D
Sbjct: 318 LTLFGLGYSWGGYESLC-LPAWPTANRTAVPWTEGGQ------VLRFHAGLEDLDDLIED 370
Query: 532 L 534
+
Sbjct: 371 V 371
>UniRef50_UPI0000E47CE2 Cluster: PREDICTED: similar to cystathionine
beta-lyase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to cystathionine beta-lyase -
Strongylocentrotus purpuratus
Length = 392
Score = 103 bits (246), Expect = 3e-21
Identities = 52/108 (48%), Positives = 69/108 (63%), Gaps = 2/108 (1%)
Frame = +1
Query: 220 VKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYE 399
+ V +PGLPSHP HE+ KKQ SG+ +F G++ + F+ S KI LA SLG E
Sbjct: 279 ISRVYYPGLPSHPDHEVAKKQMKQFSGMVAFDIKDGMEAAKTFVQSFKIILLAVSLGSTE 338
Query: 400 SLAELPSVMTHAS--VPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
SL E P+ MTH + E+R GITD LVR+SVG+E+ +D+I DLE
Sbjct: 339 SLVEHPATMTHGPYLMTKEERLAGGITDGLVRISVGIENIDDIIKDLE 386
>UniRef50_A5EU95 Cluster: Cystathionine beta-lyase; n=1;
Bradyrhizobium sp. BTAi1|Rep: Cystathionine beta-lyase -
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Length = 415
Score = 103 bits (246), Expect = 3e-21
Identities = 64/182 (35%), Positives = 91/182 (50%), Gaps = 3/182 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+ GH D++MG+ V D + +L+ +G SP DC L R L T+ +RM S
Sbjct: 207 HAGGHGDLLMGSLAVRDQALFRRLKDTARFLGYGVSPEDCALCERGLMTMPVRMRHAAAS 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKE-SNKFLSS 357
+ I WL + P+V +LHP +P HP H + K+ SG + VFS V L + L
Sbjct: 267 AAEIMTWLSQRPEVARILHPAMPDHPGHAVWKRDFSGAAAVFSVVLRPELASLQAEILRR 326
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLG--ITDSLVRLSVGLEDTEDLIAD 531
+ +F L S GG SL + + P + RA L + RLS+GLE +DLI D
Sbjct: 327 MHLFKLGASWGGVHSLIAV-------NDPRKGRASLDWLPPGPVWRLSIGLEALDDLIGD 379
Query: 532 LE 537
LE
Sbjct: 380 LE 381
>UniRef50_Q8EM13 Cluster: O-acetylhomoserine sulfhydrylase; n=86;
cellular organisms|Rep: O-acetylhomoserine sulfhydrylase
- Oceanobacillus iheyensis
Length = 556
Score = 102 bits (245), Expect = 5e-21
Identities = 59/178 (33%), Positives = 102/178 (57%), Gaps = 1/178 (0%)
Frame = +1
Query: 7 NGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSL 186
NG V +GAA + +++ L++ +G SP + +L+ + L+TL +R++QH ++L
Sbjct: 247 NGLKYVDLGAAAY---ITKLRVQLLRD-IGASLSPQNAFLLLQGLETLHLRIKQHTDNAL 302
Query: 187 IIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSG-VFSFVHVGGLKESNKFLSSLK 363
+A +L HP V+ V +PGL HP HE+ K G + +F GG + + ++
Sbjct: 303 QLAKYLQAHPAVEWVNYPGLEEHPSHELAGKYLKQSFGSIITFGISGGREAGRTLIDNVS 362
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+++ ++G +SL P+ TH + + A G+T+ LVRLSVGLE +D+IADL+
Sbjct: 363 LWSHVANVGDAKSLIIHPASTTHQQLNEDDLALSGVTEELVRLSVGLESIDDIIADLD 420
>UniRef50_Q1DAY0 Cluster: Cys/Met metabolism PLP-dependent enzyme;
n=2; Cystobacterineae|Rep: Cys/Met metabolism
PLP-dependent enzyme - Myxococcus xanthus (strain DK
1622)
Length = 394
Score = 102 bits (245), Expect = 5e-21
Identities = 59/179 (32%), Positives = 97/179 (54%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++NGHSD + G + A LR + G V P + +L R L+TL +RM+ H +
Sbjct: 207 WLNGHSDAL-GGTVSASRERMAPLRAARVLAGDVLGPFEAWLTLRGLRTLPVRMKAHVEH 265
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+ +A L++ P ++ V++PGL SHP H ++ G + +F + G ES +FL +
Sbjct: 266 AAHVARRLMESPLLERVIYPGLTSHPDHATAQELLLGGGPMVAFEIKGAGRPESMRFLEA 325
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
LK+ SLG +L + + E+R GI ++L+R+SVGLED +D++ DL
Sbjct: 326 LKVGRPGPSLGDVCTLVMHAASASARRFTPEEREAAGIRENLIRVSVGLEDPDDIVDDL 384
>UniRef50_Q11MH2 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1;
Mesorhizobium sp. BNC1|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Mesorhizobium
sp. (strain BNC1)
Length = 407
Score = 102 bits (245), Expect = 5e-21
Identities = 58/180 (32%), Positives = 93/180 (51%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+ GH+DV++GA + D + +++ + MG+ S D L R L+T+ +R+E+ S
Sbjct: 205 HAGGHADVLLGALVTRDEALFRRMKDVSRLMGLGVSADDASLALRGLQTMPLRIEREGAS 264
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKE-SNKFLSS 357
+L +A WL+ P++ VLHP L P H + K+ G S +FS +E ++ F+ +
Sbjct: 265 ALTLAQWLIARPEIARVLHPALQGDPGHHLWKRDFRGASRLFSIELAPPYQEYTSAFVDA 324
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L+IF + S G S+ PA I L+R S+GLE EDL AD+E
Sbjct: 325 LRIFRIGASWGSTHSIVTPQVPFNTIGGPA------SIPRKLIRFSIGLEPVEDLQADIE 378
>UniRef50_Q89XR2 Cluster: O-acetylhomoserine sulfhydrylase; n=24;
cellular organisms|Rep: O-acetylhomoserine sulfhydrylase
- Bradyrhizobium japonicum
Length = 433
Score = 102 bits (244), Expect = 6e-21
Identities = 51/153 (33%), Positives = 90/153 (58%), Gaps = 1/153 (0%)
Frame = +1
Query: 82 QNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQ 261
Q MG V SP + +L+ + ++T+A+RME+H +++ +A +L P+V V + G P P
Sbjct: 265 QRTMGSVLSPFNAFLLLQGIETVALRMERHVENARKVAEFLRTDPRVAWVNYTGFPDSPY 324
Query: 262 HEITKKQTSGH-SGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHAS 438
+ + +K G+ S +F+F GG++ F +LK+ T ++G +SLA P+ TH
Sbjct: 325 YPLVQKYLDGNASSLFTFGIKGGMEAGKTFYDALKLITRLVNIGDAKSLACHPASTTHRQ 384
Query: 439 VPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ AEQ+ G+ +RLS+G+E D+I D++
Sbjct: 385 MSAEQQRLAGVLPETIRLSIGIEHAADIIEDID 417
>UniRef50_Q1IZN0 Cluster: Cystathionine gamma-synthase; n=1;
Deinococcus geothermalis DSM 11300|Rep: Cystathionine
gamma-synthase - Deinococcus geothermalis (strain DSM
11300)
Length = 394
Score = 102 bits (244), Expect = 6e-21
Identities = 61/181 (33%), Positives = 99/181 (54%), Gaps = 2/181 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHS+ G +IA+ R +G S D ++ + LKTL +RM H +
Sbjct: 211 YLSGHSNAFGGVVCGTTDLIASA-RTRLTRLGGTMSAFDAWMTLQGLKTLGLRMRAHSGN 269
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSGHSGVFSFVHVGGLKESNKFLSS 357
+ +A+ L HP+V+ V HPGL SHPQ E ++ +G G+ S ++++ F+ +
Sbjct: 270 AQAVADVLANHPRVRAVYHPGLSSHPQFERAQELFPNGFGGMLS----ADIEDAPAFVRA 325
Query: 358 LK-IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
L LA SL + P +H ++P +R +LGIT +L+RLSVG+ED DL+ ++
Sbjct: 326 LSGRIPLAPSLADVVTTLSWPWGTSHRALPEAERRRLGITPNLLRLSVGIEDIGDLLTEI 385
Query: 535 E 537
E
Sbjct: 386 E 386
>UniRef50_Q979X4 Cluster: Cystathionine beta lyase /
O-succinylhomoserine lyase; n=3; Thermoplasma|Rep:
Cystathionine beta lyase / O-succinylhomoserine lyase -
Thermoplasma volcanium
Length = 368
Score = 101 bits (243), Expect = 8e-21
Identities = 58/179 (32%), Positives = 103/179 (57%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GH++ I G+A + ++ + + ++G PM YL LKT+ +R+++ ++
Sbjct: 186 FIGGHNNAIGGSA--SGSLMMDTIDENRRSLGSSMDPMSAYLFILGLKTIDLRIKRSSET 243
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ IA +L ++ V V +PGL + + K +G + SF+ G K+ KF+ SL
Sbjct: 244 AKAIARFLNENNFVSKVYYPGLSDNSDNISAKTLLNGSPPIVSFLLDEG-KDVQKFMESL 302
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+I T A ++GG S P M+H ++ +++ +LGIT +L+RLSVGLED + +I DLE
Sbjct: 303 RIITPANTMGGSNSTISNPYTMSHRNLSEDEKLRLGITKNLMRLSVGLEDLDQIIQDLE 361
>UniRef50_Q338K0 Cluster: Cys/Met metabolism PLP-dependent enzyme
family protein; n=7; Oryza sativa|Rep: Cys/Met
metabolism PLP-dependent enzyme family protein - Oryza
sativa subsp. japonica (Rice)
Length = 433
Score = 101 bits (242), Expect = 1e-20
Identities = 49/144 (34%), Positives = 88/144 (61%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH DVI G ++ +++ ++R + +G SP Y++ R LKTLA+R++ ++
Sbjct: 290 YIAGHHDVIAGCVSGSEALVS-RIRTWHHDLGGAISPNAAYMIIRGLKTLALRVQAQNRT 348
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L +A L KHPK++ V +PGL S P H + +Q +G GV ++ + +F+ +L
Sbjct: 349 ALRMAQLLEKHPKIERVYYPGLESSPWHGVATRQMAGAGGVVGLEVASDMRGAMRFVDAL 408
Query: 361 KIFTLAESLGGYESLAELPSVMTH 432
++ +A SLGG ESL + P++M++
Sbjct: 409 ELPLIATSLGGCESLVQQPAIMSY 432
>UniRef50_Q31RB7 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=3; cellular organisms|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Synechococcus sp. (strain PCC 7942) (Anacystis nidulans
R2)
Length = 434
Score = 101 bits (241), Expect = 1e-20
Identities = 50/150 (33%), Positives = 89/150 (59%), Gaps = 1/150 (0%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
+G SP + V ++TL +R E+H +++ +A WL +HP V V +PGLPSHP ++
Sbjct: 276 IGATLSPFNAQQVLLGVETLPLRAERHVRNAQAVAEWLERHPLVTWVNYPGLPSHPDYDR 335
Query: 271 TKKQT-SGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPA 447
++ +G + F GGL+ +F+S++K+ + ++ ++L P+ TH +
Sbjct: 336 AQRYLPNGAGAILGFGVQGGLEAGKRFISAVKLASNLANVLDAKTLVIHPASTTHQQLSP 395
Query: 448 EQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
E++A G++ VRLSVGLE +D++ADL+
Sbjct: 396 EEQAAAGVSPDFVRLSVGLEHLDDILADLD 425
>UniRef50_A3K0Q5 Cluster: O-succinylhomoserine sulfhydrylase; n=3;
Rhodobacteraceae|Rep: O-succinylhomoserine sulfhydrylase
- Sagittula stellata E-37
Length = 391
Score = 101 bits (241), Expect = 1e-20
Identities = 54/178 (30%), Positives = 94/178 (52%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+++G ++ G +I + G +P + ++L+TL +R+ +
Sbjct: 207 HVDGQGRMLGGMICGPKELIRGPIEAYMKHSGGAMNPFTAWTHLKALETLELRVRAQAQG 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ +A L H K+ V +P +HPQHE+ + Q+ V F GG +FL++L
Sbjct: 267 AMALAEALNGHEKLNHVRYPTHAAHPQHELARSQSEAGGTVLCFDIKGGKDACFRFLNAL 326
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+I ++ + +++A P+ TH +P EQ+ LGIT LVRLSVGLEDT D+++DL
Sbjct: 327 EIVLISNNFADAKTIATHPATTTHQRLPQEQKDILGITPGLVRLSVGLEDTRDILSDL 384
>UniRef50_Q7VIG9 Cluster: O-acetylhomoserine (Thiol)-lyase MetY;
n=18; Epsilonproteobacteria|Rep: O-acetylhomoserine
(Thiol)-lyase MetY - Helicobacter hepaticus
Length = 430
Score = 100 bits (240), Expect = 2e-20
Identities = 53/156 (33%), Positives = 97/156 (62%), Gaps = 2/156 (1%)
Frame = +1
Query: 76 FLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSH 255
+L+N +G SP +++ + L+TL +R+++H +++L +A +L HPKV+ V + GL S+
Sbjct: 272 WLRN-IGATLSPQASWIILQGLETLELRIKKHSQNALKVAEFLQSHPKVQSVAYAGLTSN 330
Query: 256 PQHEITKK--QTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMT 429
P + + +K + S SG+ SF +E+ K ++ +IF + ++G +SL P+ T
Sbjct: 331 PYNRLLQKYYKDSQASGLISF-EAQSFEEAQKICNATEIFAVVVNIGDSKSLIIHPASTT 389
Query: 430 HASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
H+ + A++ + GIT +RLS+GLE +DLI DL+
Sbjct: 390 HSQLNADELSSAGITPCTIRLSIGLESADDLIQDLK 425
>UniRef50_Q5NPR0 Cluster: Cystathionine beta-lyases; n=5;
Sphingomonadales|Rep: Cystathionine beta-lyases -
Zymomonas mobilis
Length = 402
Score = 100 bits (240), Expect = 2e-20
Identities = 61/179 (34%), Positives = 101/179 (56%), Gaps = 1/179 (0%)
Frame = +1
Query: 4 MNGHSDVIMGA-AIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
M+G V+ G+ A N V L F++N G SP + ++V + L+TL +R + ++
Sbjct: 219 MDGQGRVLAGSVAGSNKFVNETLLPFIRNT-GPNLSPFNAWVVMKGLETLELRSIRQSEN 277
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ I+A +L K ++ V +PGL SHPQH + KKQ V + +++ L++L
Sbjct: 278 AQILAEFLEK--RIPRVSYPGLKSHPQHALAKKQMKTGGTVLALFLGKDRQQALSLLNNL 335
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
++ ++ +LG SL P TH+ V ++R +GIT+ ++R SVGLED EDL DL+
Sbjct: 336 ELIDISNNLGDTRSLMTHPCSTTHSGVAEKERLAMGITEDMLRFSVGLEDVEDLKEDLD 394
>UniRef50_Q28Q09 Cluster: Cystathionine gamma-synthase; n=7;
Rhodobacterales|Rep: Cystathionine gamma-synthase -
Jannaschia sp. (strain CCS1)
Length = 396
Score = 100 bits (240), Expect = 2e-20
Identities = 57/178 (32%), Positives = 91/178 (51%), Gaps = 2/178 (1%)
Frame = +1
Query: 10 GHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLI 189
GHSDV +G D + +G+ P+P +C+L R L T +R E+ + ++
Sbjct: 213 GHSDVTLGYVAARDADQMRAIYDFAVTVGMTPAPNECWLAERGLYTFPLRFEKAQANAAG 272
Query: 190 IANWLLKHPKVKDVLHPGLPSHPQHEI-TKKQTSGHSGVFSF-VHVGGLKESNKFLSSLK 363
+A++L HPKV VL+PG HP H + T + SF ++ +++ + +
Sbjct: 273 LADYLAAHPKVARVLYPGRDDHPDHGLATALVGQAFGNMVSFELNDASEAAADRMVQAAP 332
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
A +LG + P+ +H + AE RA LGI+D R+SVG+ED + LIAD E
Sbjct: 333 DLPFAPTLGDVGTTLSHPASSSHRGLTAEGRAALGISDGFFRVSVGIEDLDLLIADFE 390
>UniRef50_A3U7R8 Cluster: O-acetylhomoserine sulfhydrylase; n=8;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Croceibacter atlanticus HTCC2559
Length = 438
Score = 100 bits (240), Expect = 2e-20
Identities = 54/148 (36%), Positives = 85/148 (57%), Gaps = 1/148 (0%)
Frame = +1
Query: 94 GIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEIT 273
G SP + + + + L+TL IR+E+H K++L +A WL + +V V +PGL S + +
Sbjct: 270 GAALSPFNAFQILQGLETLEIRLEKHSKNALNLATWLQEQEEVTWVNYPGLKSSKYNSLA 329
Query: 274 KKQT-SGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAE 450
KK G SGV +F GG + + +IF+L ++G +SL P+ TH + E
Sbjct: 330 KKYLPDGQSGVVTFGVKGGYNSAKIIANETEIFSLLANIGDSKSLIIHPASTTHQQLTDE 389
Query: 451 QRAQLGITDSLVRLSVGLEDTEDLIADL 534
++ G+T L+RLSVGLE +DL +DL
Sbjct: 390 EQESTGVTKDLIRLSVGLEHLDDLKSDL 417
>UniRef50_Q59829 Cluster: Putative cystathionine gamma-lyase; n=8;
Actinomycetales|Rep: Putative cystathionine gamma-lyase
- Streptomyces coelicolor
Length = 392
Score = 100 bits (240), Expect = 2e-20
Identities = 56/177 (31%), Positives = 94/177 (53%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
+ GH DV++G D A +R + +G +P PM+ +L +RS+ TL +R+++ ++
Sbjct: 218 LTGHGDVLLGYVAGRDAGAMAAVRRWRKIVGAIPGPMEAWLAHRSIATLQLRVDRQDSTA 277
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
L +A L P++ + +PGLP P H++ +Q + V SF + +++FL +L+
Sbjct: 278 LKVAEALRTRPEITGLRYPGLPDDPSHKVASQQMLRYGCVVSFT-LPSRARADRFLDALR 336
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ A S GG S AE +VP + +RLSVG ED +DL+ADL
Sbjct: 337 LVEGATSFGGVRSTAERRGRWGGDAVP----------EGFIRLSVGAEDPDDLVADL 383
>UniRef50_Q5LWC9 Cluster: Cys/Met metabolism PLP-dependent enzyme
family protein; n=5; cellular organisms|Rep: Cys/Met
metabolism PLP-dependent enzyme family protein -
Silicibacter pomeroyi
Length = 403
Score = 100 bits (239), Expect = 2e-20
Identities = 72/194 (37%), Positives = 105/194 (54%), Gaps = 15/194 (7%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAM--GIVPSPMDCYLVNRSLKTLAIRMEQHK 174
Y+ GH D + GA + + +++R ++ A+ G V SP + +L+ R TL +RM+ H
Sbjct: 212 YICGHGDAVAGA-VCGRADLVSRMR-VEAAIHHGGVLSPFNAWLIARGAATLPLRMKAHA 269
Query: 175 KSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVG----GLKESN 342
+ +A WL P+V V++PGLPSHPQ E+ +Q S S + SF VG G + +
Sbjct: 270 AGAHAVAEWLEADPRVGRVIYPGLPSHPQAELAARQMSNMSAMISF-QVGDAATGERLAR 328
Query: 343 KFLSSLKIFTLAESLG---------GYESLAELPSVMTHASVPAEQRAQLGITDSLVRLS 495
+ + L++ A SLG G E L E + A + A RA G D + RLS
Sbjct: 329 QMIERLEVIHYAVSLGHHRSLIFWMGTEGLMETSFRLEGAQLEA-YRAYAG--DGIFRLS 385
Query: 496 VGLEDTEDLIADLE 537
VGLED EDLIADL+
Sbjct: 386 VGLEDPEDLIADLD 399
>UniRef50_A7HB44 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent protein; n=2;
Anaeromyxobacter|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent protein - Anaeromyxobacter
sp. Fw109-5
Length = 363
Score = 99.5 bits (237), Expect = 4e-20
Identities = 62/178 (34%), Positives = 94/178 (52%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GHSD + G + D +A LR + G VP ++ +LV R ++TL +R+ Q +
Sbjct: 189 FLAGHSDALGGVLVARDQALAEGLRATRTVTGGVPGALETWLVLRGVRTLGLRVRQQTAN 248
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A +L + +V V HP LPSHP HE+ K+Q G + S + +G + +L
Sbjct: 249 ATRLAAFLER--RVARVWHPSLPSHPGHELAKRQMRGPGPILS-IELGSEAAARALPRAL 305
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+IF A SLGG ESL E + PA L+RL+VG+ED +DL DL
Sbjct: 306 RIFRDATSLGGVESLVEWRRKQDPHAPPA-----------LLRLAVGIEDPDDLEGDL 352
>UniRef50_Q5UZ20 Cluster: O-acetylhomoserine (Thiol)-lyase; n=10;
cellular organisms|Rep: O-acetylhomoserine (Thiol)-lyase
- Haloarcula marismortui (Halobacterium marismortui)
Length = 432
Score = 99.5 bits (237), Expect = 4e-20
Identities = 55/160 (34%), Positives = 90/160 (56%), Gaps = 1/160 (0%)
Frame = +1
Query: 61 AAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHP 240
AA R L++ +G SP D + + L+TL RM++H +++ +A +L HP+V V +P
Sbjct: 266 AAIARGLRD-LGCQQSPFDAWQTMQGLETLPARMDRHCDNAMGVAEFLADHPEVSWVTYP 324
Query: 241 GLPSHPQHEITKKQTSG-HSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELP 417
GL H H+ K G + G+ +F G + + S +I +L ++G ++L P
Sbjct: 325 GLEDHETHDTASKYLDGGYGGMITFGLDAGYDAARTTVESTEIASLLANVGDAKTLIIHP 384
Query: 418 SVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ TH + E++A G+TD +VRLSVG E ED+ ADL+
Sbjct: 385 ASTTHQQLTDEEKAAAGVTDDMVRLSVGTESVEDIKADLD 424
>UniRef50_Q11C77 Cluster: Cystathionine beta-lyase; n=1;
Mesorhizobium sp. BNC1|Rep: Cystathionine beta-lyase -
Mesorhizobium sp. (strain BNC1)
Length = 388
Score = 99.1 bits (236), Expect = 6e-20
Identities = 63/179 (35%), Positives = 94/179 (52%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD ++G N+ + +R G V + L R L+T+ +R+++H +
Sbjct: 210 YIVGHSDAMLGVVAANE-LTYGPIRQAIRDFGAVVGTEEANLGLRGLRTMEVRLQRHFAA 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVG-GLKESNKFLSS 357
+L IA WL P V V+HP LPS P H + K+ SG SG+FS +F+ S
Sbjct: 269 ALEIATWLEGQPGVARVMHPALPSFPGHTLWKRDFSGASGLFSIELANRDPAAMTRFVDS 328
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
LK+F + S GG+ESL LP+ H P ++ + +VR +GLE +DL ADL
Sbjct: 329 LKLFKIGFSWGGFESLV-LPA---H---PERRKVAVWTGGPVVRFHIGLEAIDDLKADL 380
>UniRef50_A7DB98 Cluster: Cystathionine gamma-synthase; n=2;
Methylobacterium extorquens PA1|Rep: Cystathionine
gamma-synthase - Methylobacterium extorquens PA1
Length = 405
Score = 98.7 bits (235), Expect = 7e-20
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 2/180 (1%)
Frame = +1
Query: 4 MNGHSDVIMGA-AIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+NGHSDV+ G A +L ++ G + P + YL+ R L+TL +R
Sbjct: 223 LNGHSDVVAGVLAGARKDAFWDRLVAIRGGWGAILGPFEAYLLMRGLRTLPLRAAAQSAG 282
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHV-GGLKESNKFLSS 357
+L +A L HP V+ VL+PGLP HP H + +Q +G G + V GG + + +
Sbjct: 283 ALHLAQRLSAHPLVRAVLYPGLPDHPGHAVAARQMTGGFGYMLSIRVAGGESAAIETAAR 342
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ ++ A SLGG ESL E + + P L+RLS G+ED +DL+ DL+
Sbjct: 343 VALWKRATSLGGVESLIEHRASVEGPGTPC--------PPDLLRLSTGIEDPDDLLRDLD 394
>UniRef50_Q49UL3 Cluster: Cystathionine beta-lyase cystathionine
gamma-synthase; n=14; Staphylococcus|Rep: Cystathionine
beta-lyase cystathionine gamma-synthase - Staphylococcus
saprophyticus subsp. saprophyticus (strain ATCC 15305
/DSM 20229)
Length = 367
Score = 98.3 bits (234), Expect = 1e-19
Identities = 59/178 (33%), Positives = 95/178 (53%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+DV+ G V D +A +L L N +G SP D YL+ R LKTL +RM++ + +
Sbjct: 194 YIGGHNDVLAGVVTVKDNQLAEQLGQLHNMIGATLSPFDSYLLQRGLKTLHLRMDRSEYN 253
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +++ + D+ I K SG +G+ S + + + +KFL L
Sbjct: 254 AKLLSE------RCSDL----------EAIDKVLYSGRTGMLS-LRLNKDYKVDKFLEHL 296
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ AESLGG E+ P TH +P ++ + GI + L+RLS+G+ED ED+ D+
Sbjct: 297 NVCIFAESLGGTETFITFPYTQTHVDMPDAEKDKRGIDEYLIRLSIGIEDYEDIEQDI 354
>UniRef50_Q76K51 Cluster: O-acetyl-L-homoserine sulfhydrylase; n=4;
Thermus|Rep: O-acetyl-L-homoserine sulfhydrylase -
Thermus thermophilus
Length = 412
Score = 98.3 bits (234), Expect = 1e-19
Identities = 53/148 (35%), Positives = 87/148 (58%)
Frame = +1
Query: 94 GIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEIT 273
G+ SP + YL+ + L+T+A+R+ + +++ +A L HPKVK + +PGLP P H
Sbjct: 261 GMALSPFNAYLLFQGLETVALRVARMSETARFLAERLQGHPKVKALRYPGLPEDPAHRNA 320
Query: 274 KKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQ 453
+K + G + +G L+ +++FL ++++ A +LG +L P TH+ + E
Sbjct: 321 RKYLAS-GGPILTLDLGDLERASRFLGAIRLLK-AANLGDARTLLVHPWTTTHSRLKEEA 378
Query: 454 RAQLGITDSLVRLSVGLEDTEDLIADLE 537
R Q G+T LVR+SVGLED DL+A E
Sbjct: 379 RLQAGVTPGLVRVSVGLEDPLDLLALFE 406
>UniRef50_A4FF27 Cluster: Methionine gamma-lyase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep: Methionine
gamma-lyase - Saccharopolyspora erythraea (strain NRRL
23338)
Length = 396
Score = 97.1 bits (231), Expect = 2e-19
Identities = 55/180 (30%), Positives = 91/180 (50%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH D + G A+ D ++R +G +P+ +L R L+TL++R+++ +
Sbjct: 209 YIGGHGDTLGGIAVFADRERHRRIRDYSCQLGATAAPIPAWLALRGLRTLSLRVQRQCDN 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHS--GVFSFVHVGGLKESNKFLS 354
+ ++A L P V V HP L SHP E+ + G + GV GG + F
Sbjct: 269 AKLLAERLSADPAVTAVHHPSLESHPDRELAVRLLDGGAGGGVLGLDLAGGREAGRVFSD 328
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+L++ A SLG ++L P+ +H + Q +GI VR++VG+E EDL AD+
Sbjct: 329 ALRLALAAVSLGDVKTLVSHPAGTSHRQLDERQLEAVGIGPGTVRIAVGIEHPEDLWADV 388
>UniRef50_Q895W3 Cluster: O-acetylhomoserine sulfhydrylase; n=40;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Clostridium tetani
Length = 462
Score = 96.7 bits (230), Expect = 3e-19
Identities = 53/160 (33%), Positives = 92/160 (57%), Gaps = 1/160 (0%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
++ +++ L++ +G SP + +L N L+TL +RME+H ++L +A +L H KV V
Sbjct: 296 IVKCRVQLLRD-LGTCLSPFNAFLNNLGLETLHLRMERHCSNTLKLAKFLENHKKVNWVN 354
Query: 235 HPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES-NKFLSSLKIFTLAESLGGYESLAE 411
+PGL ++ +++ K S SG V G K++ +KF+ +LK+ L LG +
Sbjct: 355 YPGLYNNSNYQLANKYLSKGSGAILTFGVKGCKDAGSKFIRNLKLAALVVHLGDARTSVL 414
Query: 412 LPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
P+ TH + +++ G+ L+R+SVG+ED EDLI D
Sbjct: 415 QPATTTHRQLNEKEQISSGVYPDLIRVSVGIEDPEDLIND 454
>UniRef50_Q2K0N3 Cluster: Cystathionine gamma-synthase protein; n=7;
Alphaproteobacteria|Rep: Cystathionine gamma-synthase
protein - Rhizobium etli (strain CFN 42 / ATCC 51251)
Length = 390
Score = 96.7 bits (230), Expect = 3e-19
Identities = 65/179 (36%), Positives = 90/179 (50%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G + +IA +G SP D +L+ R L+TL +RM+ H+ S
Sbjct: 209 YLGGHSDVVAGVVAGSKEMIARVKAEAYPYLGGKLSPFDAWLLIRGLRTLPLRMKAHEAS 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+L IA L + V+ V HPGL + +G SG+FSF+ G+ + +F L
Sbjct: 269 ALEIARRLQRLEVVETVCHPGLANR-----LPAGLNGTSGLFSFIFREGV-DIRRFADHL 322
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
K+F L S GG+ESL V+ GI VRL VGLE TE L D+E
Sbjct: 323 KLFKLGVSWGGHESLIVPGEVVLQQKAQPNSAQTFGIHARSVRLHVGLEGTEALWRDIE 381
>UniRef50_A1SMU4 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=6; Bacteria|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 428
Score = 96.7 bits (230), Expect = 3e-19
Identities = 53/163 (32%), Positives = 94/163 (57%), Gaps = 2/163 (1%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
+I A+ L+N G +PM+ +L + L+TL +RME+H +++L +A +L H V V
Sbjct: 260 IIRARTVLLRNTGGAT-TPMNSWLFLQGLETLHLRMERHSENALQVAEFLNGHEGVSWVN 318
Query: 235 HPGLPSHPQHEITKK--QTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLA 408
+PGL P E + G+ G+ SF G + +F+ +L +F+ ++G +SLA
Sbjct: 319 YPGLADSPHKETFDRIGTGKGYGGLLSFGLKSGREGGKRFIEALGLFSHLANIGDAKSLA 378
Query: 409 ELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ TH+ + ++ G+ + +VRLS+G+E+ ED+IADL+
Sbjct: 379 IHNATTTHSQLTPDELEAAGVPEDMVRLSIGIENVEDIIADLD 421
>UniRef50_Q4Q511 Cluster: Cystathionine beta-lyase, putative; n=3;
Leishmania|Rep: Cystathionine beta-lyase, putative -
Leishmania major
Length = 399
Score = 96.3 bits (229), Expect = 4e-19
Identities = 61/180 (33%), Positives = 93/180 (51%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+++G N+ KLR + + VPS DCYL R L+T+ IR+++ ++
Sbjct: 212 YVGGHSDLLLGLISANEKWYP-KLRGFMSLLQSVPSNEDCYLGLRGLRTMYIRLKEAEQR 270
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV--HVGGLKESNKFLS 354
L +A ++ +V VLHP PS HEI ++ +G SG+FS V L++ + +
Sbjct: 271 GLEMARFMESRKEVLKVLHPAFPSCRGHEIWRRDFTGSSGLFSIVLRPEYALQDVERMID 330
Query: 355 SLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K+F++ S GG+ESL VM L+R +GLE EDL DL
Sbjct: 331 GYKLFSIGFSWGGFESL-----VMCFDCTKFRTATTFAPGGILLRFQIGLEGLEDLKQDL 385
>UniRef50_Q8J0B2 Cluster: Homocysteine synthase-like protein; n=2;
Neotyphodium uncinatum|Rep: Homocysteine synthase-like
protein - Neotyphodium uncinatum
Length = 473
Score = 96.3 bits (229), Expect = 4e-19
Identities = 50/134 (37%), Positives = 77/134 (57%), Gaps = 1/134 (0%)
Frame = +1
Query: 139 LKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTS-GHSGVFSFV 315
L++LA+R E+H +++ IA+WL +HP V V + G P+HP H+ K G V F
Sbjct: 301 LESLAVRCERHAQNAAKIADWLREHPLVAWVSYVGHPNHPDHQGALKYLKRGFGSVICFG 360
Query: 316 HVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLS 495
GG + F +LK+ +LG ++L P+ TH +E RA+ G+TD ++RLS
Sbjct: 361 LRGGFEAGALFCDALKMVITTTNLGDAKTLILHPASTTHEHFSSEHRAEAGVTDDMIRLS 420
Query: 496 VGLEDTEDLIADLE 537
VG+E +D+ AD E
Sbjct: 421 VGIEQIKDIKADFE 434
>UniRef50_Q8RI68 Cluster: Cystathionine gamma-synthase; n=1;
Fusobacterium nucleatum subsp. nucleatum|Rep:
Cystathionine gamma-synthase - Fusobacterium nucleatum
subsp. nucleatum
Length = 396
Score = 95.9 bits (228), Expect = 5e-19
Identities = 58/180 (32%), Positives = 94/180 (52%), Gaps = 3/180 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
+MNGHSD I G+ +I A + ++ G P + + +S T+ +R+++ +
Sbjct: 208 FMNGHSDAIAGSITSTTEIIDA-IHPVRMLCGTPGDPHAAHAMMKSFATMDLRLKKQMSN 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGH---SGVFSFVHVGGLKESNKFL 351
+ +A L ++ V V HP L S QHE+ K + + SG+ SF+ ++ +KF+
Sbjct: 267 AAKLAAALEENKYVSKVNHPSLKSFSQHELALKLFTSNDTMSGMMSFIVPEDFEKIDKFM 326
Query: 352 SSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIAD 531
L A +LGG + P +H+ +P E R +GIT L RLSVG+ED +DLI D
Sbjct: 327 LRLNFAHYAMTLGGVRTTLVHPVTSSHSHMPDEARRAMGITPGLFRLSVGIEDVDDLIED 386
>UniRef50_Q8KEI6 Cluster: Trans-sulfuration enzyme family protein;
n=2; Chlorobaculum tepidum|Rep: Trans-sulfuration enzyme
family protein - Chlorobium tepidum
Length = 219
Score = 95.9 bits (228), Expect = 5e-19
Identities = 49/150 (32%), Positives = 86/150 (57%), Gaps = 1/150 (0%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
+G SP + ++ + ++TL +RM +H +++L +A L HPKV V +PGLP P + +
Sbjct: 64 LGAAISPDNSWIFIQGVETLPVRMIRHSENALKVAGHLKNHPKVAWVRYPGLPDDPSYAL 123
Query: 271 TKKQTS-GHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPA 447
+ G G+ F GG + K + ++ +F+ ++G +SL P+ +H+ +
Sbjct: 124 ASRDLKRGFGGMVVFGVKGGYDAAVKIIDTIDLFSHLANVGDAKSLILHPASTSHSQMTE 183
Query: 448 EQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
EQR G++ L+RLS+GLE +DLIA L+
Sbjct: 184 EQRVASGLSSDLIRLSIGLEHPDDLIAALD 213
>UniRef50_Q9KFD9 Cluster: Cystathionine gamma-synthase; n=3;
Bacillus|Rep: Cystathionine gamma-synthase - Bacillus
halodurans
Length = 381
Score = 95.5 bits (227), Expect = 7e-19
Identities = 58/176 (32%), Positives = 90/176 (51%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV G +V I ++R +G SP + +L +R LKTLA+RME+ ++
Sbjct: 207 YIGGHSDVTAGV-VVGSAEIIQQVRQKVATLGCNLSPFEAWLASRGLKTLALRMERQGEN 265
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A + HP V V +P T G+ + + + + E+ F SL
Sbjct: 266 AQALATFFADHPGVSQVFYP----------TTVSKRGNGAIVT-IRLAEKVEAATFFESL 314
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIA 528
+A +L G E+ P +H +VP R +LGI LVR+SVG+ED ED++A
Sbjct: 315 DWVKIAPTLAGVETTVSYPIQTSHRTVPESLRQELGIDKQLVRISVGIEDIEDIMA 370
>UniRef50_Q8G436 Cluster: Possible cystathionine gamma lyase; n=3;
Bacteria|Rep: Possible cystathionine gamma lyase -
Bifidobacterium longum
Length = 507
Score = 95.5 bits (227), Expect = 7e-19
Identities = 67/184 (36%), Positives = 90/184 (48%), Gaps = 5/184 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFL-QNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGH D + G +I ++RF Q G + SP + +L+NR TL +R+ QH
Sbjct: 319 YINGHGDAL-GGSIATTKARTDQIRFTAQVNFGGIISPFNAWLINRGSVTLPLRIRQHNA 377
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ----TSGHSGVFSFVHVGGLKESNK 345
+L IA L V+ V +PGL SHP HE+ Q SG GV SF N+
Sbjct: 378 LALAIAKHLESLDVVRFVAYPGLESHPHHEVAVSQLARPDSGFGGVLSFGLDTNHDGHNR 437
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
F+S L + T A SLG ESL V + RL+VGLEDT+DLI
Sbjct: 438 FVSKLNVITSAVSLGHDESLI----VFLGEDDERQYLYPPEFHRGFFRLAVGLEDTDDLI 493
Query: 526 ADLE 537
D++
Sbjct: 494 RDID 497
>UniRef50_A5MZA3 Cluster: O-acetyl-L-homoserine
sulfhydrylase-related protein; n=8; Bacteria|Rep:
O-acetyl-L-homoserine sulfhydrylase-related protein -
Clostridium kluyveri DSM 555
Length = 428
Score = 95.5 bits (227), Expect = 7e-19
Identities = 50/153 (32%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Frame = +1
Query: 79 LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHP 258
L G + SP +++N L++L +RM +H ++ +A +L HPKV V + GLP
Sbjct: 268 LMRDFGSIQSPQHAFILNLGLESLHVRMPRHCENGQAVAEFLQNHPKVAYVNYCGLPGDK 327
Query: 259 QHEITKKQT-SGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHA 435
++I +K +G GV SF GG +E+ F+ +LK+ + + S P+ TH
Sbjct: 328 YYKIAQKYLPNGSCGVVSFGLKGGREEAEIFMKNLKLVAIETHVADARSCCLNPATSTHR 387
Query: 436 SVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ E+ + G+ L+R+S G+ED EDLI D+
Sbjct: 388 QMNDEELKEAGVPAELIRISCGIEDKEDLIYDI 420
>UniRef50_A0V4A3 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=3; Proteobacteria|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Delftia acidovorans SPH-1
Length = 475
Score = 95.5 bits (227), Expect = 7e-19
Identities = 51/162 (31%), Positives = 91/162 (56%), Gaps = 2/162 (1%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
+ A+ L+N G +P +L+ + L+TL +R E+ +++L + ++L +HP V+ +
Sbjct: 276 IARARAVLLRNC-GAALAPHSAFLLLQGLETLGLRQERASRNTLAVIDFLQRHPLVERIH 334
Query: 235 HPGLPSHPQHEITKKQT-SGH-SGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLA 408
H H H + +Q GH + F GG + F +L++F ++G +SLA
Sbjct: 335 HASQSGHADHALALRQLRGGHVPALLGFELRGGRPAARAFYDALRLFLRLVNIGDSKSLA 394
Query: 409 ELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+P+ TH+ + E+ A++GI LVRLS+G+E +DL+ADL
Sbjct: 395 AIPAETTHSLLSDEELARVGIAPGLVRLSIGIEHPQDLLADL 436
>UniRef50_Q7WKX4 Cluster: Cys/Met metabolism PLP-dependent enzyme;
n=23; Proteobacteria|Rep: Cys/Met metabolism
PLP-dependent enzyme - Bordetella bronchiseptica
(Alcaligenes bronchisepticus)
Length = 414
Score = 95.1 bits (226), Expect = 9e-19
Identities = 55/133 (41%), Positives = 80/133 (60%), Gaps = 1/133 (0%)
Frame = +1
Query: 142 KTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHV 321
+TLA+RM +H ++L +A +L HP V V +PGL SH QH+ + G G V +
Sbjct: 274 ETLALRMARHCSNALALATFLQGHPGVARVHYPGLSSHAQHQRASELFDGRYGGLLGVEL 333
Query: 322 GGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMT-HASVPAEQRAQLGITDSLVRLSV 498
+ FL+ L+I +A LG SLA LP+ T + + AE+RAQ+GI DSL+R+SV
Sbjct: 334 AEGIDCFDFLNRLRIVLMATHLGDTRSLA-LPAAHTIYYEMGAEKRAQMGIADSLIRVSV 392
Query: 499 GLEDTEDLIADLE 537
G+ED DL+ D +
Sbjct: 393 GIEDEADLLFDFD 405
>UniRef50_A5MZ94 Cluster: O-acetyl-L-homoserine
sulfhydrylase-related protein; n=4; Bacteria|Rep:
O-acetyl-L-homoserine sulfhydrylase-related protein -
Clostridium kluyveri DSM 555
Length = 442
Score = 94.7 bits (225), Expect = 1e-18
Identities = 58/158 (36%), Positives = 88/158 (55%), Gaps = 1/158 (0%)
Frame = +1
Query: 67 KLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGL 246
+L +L N G SP D YLV L+TL+ R+E+ ++ I ++L + V+ + +P L
Sbjct: 270 RLNYL-NYFGAALSPFDAYLVLLGLETLSERIEKQLSNTKKIISYLQESDNVQWIKYPSL 328
Query: 247 PSHPQHEITKKQT-SGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSV 423
P E++KK G VFSF G E +KFL+S+K+F+ ++G SL
Sbjct: 329 NDSPYKELSKKYLPKGAGSVFSFGLKGTDDEIDKFLNSIKLFSYHANIGDSRSLIVNSPK 388
Query: 424 MTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
TH+ + E++ I + +RLS+GLED EDLI DLE
Sbjct: 389 TTHSELTPEEKEFSHIESNTIRLSIGLEDAEDLIWDLE 426
>UniRef50_Q98LV9 Cluster: Methionine gamma lyase; n=4;
Rhizobiales|Rep: Methionine gamma lyase - Rhizobium loti
(Mesorhizobium loti)
Length = 395
Score = 93.9 bits (223), Expect = 2e-18
Identities = 59/179 (32%), Positives = 92/179 (51%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD + G + I + +G SP + +L+ R L+TL +R+ H KS
Sbjct: 214 YLGGHSDTVAGVVAGSAAHIKHINEQTYSYLGGKLSPFEAWLLLRGLRTLPLRLPHHMKS 273
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
L +A L H V+ V HP +HP K +G++G+FSF + + F+ +L
Sbjct: 274 GLTLAERLKAHAHVERVNHPAYSNHP----GKATLAGYAGLFSFEVTDDI-DIPVFVDAL 328
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPA-EQRAQLGITDSLVRLSVGLEDTEDLIADL 534
K F + S GG+ESL +P+ + P A+ G++ +R +VGLE EDL AD+
Sbjct: 329 KYFRIGVSWGGHESLV-VPAKASLEQTPGLNSMARFGVSPRTIRFNVGLESVEDLWADV 386
>UniRef50_Q0SFV6 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=1; Rhodococcus sp.
RHA1|Rep: O-acetylhomoserine
aminocarboxypropyltransferase - Rhodococcus sp. (strain
RHA1)
Length = 432
Score = 93.5 bits (222), Expect = 3e-18
Identities = 55/161 (34%), Positives = 88/161 (54%), Gaps = 1/161 (0%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
++ AK + + + +G SP + + + + L+TL +R+E+ S+L IA +L HP V V
Sbjct: 263 LVYAKTKIVHD-LGPALSPFNSFQLLQGLETLDLRLERQVGSALAIARFLDGHPAVAKVN 321
Query: 235 HPGLPSHPQHEITKKQTS-GHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAE 411
+PGLP + H ++ G VFSF + KF+ SL++F + ++G SL
Sbjct: 322 YPGLPDNRWHAAAQRYLPRGAGSVFSFDLAVDDSKVAKFIDSLQLFAIVANIGDARSLVV 381
Query: 412 LPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
P+ TH+ + Q G D VRLS+GLE+ EDL+ DL
Sbjct: 382 HPATTTHSHLGDTQLRDAGFGDRTVRLSIGLENLEDLVDDL 422
>UniRef50_Q1NS60 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=3; Bacteria|Rep:
O-acetylhomoserine aminocarboxypropyltransferase - delta
proteobacterium MLMS-1
Length = 415
Score = 93.1 bits (221), Expect = 4e-18
Identities = 51/160 (31%), Positives = 85/160 (53%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
++AA R + +G +P + YL L+TLA+R+EQ ++L +A +L P V+ V
Sbjct: 247 LLAALRREIARDLGACLAPHNAYLQTLGLETLALRVEQSCANALELARFLAGQPAVRKVN 306
Query: 235 HPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAEL 414
+PGL HP HE+ ++Q +G G + + L L++ A ++ ++LA
Sbjct: 307 YPGLEEHPDHELARRQFNGRFGGILTFELDDRQACFALLDKLQLIRRATNINDNKTLAIH 366
Query: 415 PSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
P+ A QR +G+T+ L+R+S G+ED DL DL
Sbjct: 367 PASTIFTEFGAAQREAMGVTEGLLRISAGIEDPADLQDDL 406
>UniRef50_A6GJL1 Cluster: Methionine gamma-lyase; n=1; Plesiocystis
pacifica SIR-1|Rep: Methionine gamma-lyase -
Plesiocystis pacifica SIR-1
Length = 399
Score = 93.1 bits (221), Expect = 4e-18
Identities = 58/178 (32%), Positives = 86/178 (48%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
+NGHSDV+ GA + + A ++ G V P +L+ R ++TL +R ++S
Sbjct: 218 LNGHSDVVAGAIASDAARVDACFATIKRQGGCV-DPQAAWLLQRGIRTLPLRWAAQTRNS 276
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
+A L HPKV+ V PG + + +F GG +++
Sbjct: 277 EFLAERLRDHPKVRAVHWPGFE---MEAMVAAPLRSPGTMLAFELEGGFPAVRALFGAVQ 333
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ T A SLGG E+L P+ +H + E R GI D LVRLS G+ED +DL DLE
Sbjct: 334 LCTHAVSLGGLETLLSSPAWTSHTQLAPEVRRARGIADGLVRLSAGIEDCQDLWDDLE 391
>UniRef50_A1ZIW0 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1; Microscilla
marina ATCC 23134|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Microscilla
marina ATCC 23134
Length = 391
Score = 93.1 bits (221), Expect = 4e-18
Identities = 57/180 (31%), Positives = 97/180 (53%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSD + G + + +G V +P + +L+ R L+TL RM++ +
Sbjct: 205 YISGHSDTVAGVLCASKAMTNKIFASEYMTLGGVVAPFNAWLLLRGLRTLPTRMDRVSAT 264
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+ I+ N+L +H V + +P L S PQ+ + KKQ + +G F+ + + + KF +
Sbjct: 265 TAIVVNYLQEHSMVSKIYYPYLESDPQYTLAKKQMTKGAGQFTIELAIDDIALIEKFCNH 324
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L+ F +A S GG+ESL P+ + H S RA + +++R +GLE E LIAD+E
Sbjct: 325 LQRFLMACSWGGHESLI-FPACVLHTSA-NYNRAVPPV--NMIRFCIGLETPEALIADIE 380
>UniRef50_A0JSB0 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=130; cellular organisms|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Arthrobacter sp. (strain FB24)
Length = 444
Score = 93.1 bits (221), Expect = 4e-18
Identities = 54/159 (33%), Positives = 84/159 (52%), Gaps = 2/159 (1%)
Frame = +1
Query: 67 KLRFLQ-NAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPG 243
KLR Q +G SP + + + ++TL R+++H K++ +A WL +V V G
Sbjct: 262 KLRCEQLRDIGPALSPQSAFQLLQGVETLPQRLDEHLKNAQAVAEWLEADERVAYVNFSG 321
Query: 244 LPSHPQHEITKKQTS-GHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPS 420
LPSHP E +K G VFSF GG KF+ +L++ + ++G +L P
Sbjct: 322 LPSHPHFERAQKYLPLGPGSVFSFGVKGGRAAGQKFIEALQLASHLANVGDSRTLVIHPG 381
Query: 421 VMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
TH + Q G+ + LVR+S+GLED ED++ DL+
Sbjct: 382 STTHQQLSPAQLESAGVPEDLVRISIGLEDLEDILWDLD 420
>UniRef50_Q1V2M7 Cluster: Cystathionine beta-lyase; n=2; Candidatus
Pelagibacter ubique|Rep: Cystathionine beta-lyase -
Candidatus Pelagibacter ubique HTCC1002
Length = 391
Score = 92.7 bits (220), Expect = 5e-18
Identities = 62/180 (34%), Positives = 95/180 (52%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +GHSDV+ G+ VN ++ G+ P D YL+ R L+TL +R+++H+KS
Sbjct: 210 YYSGHSDVMGGSLAVNKKAFK-QVDKANKITGLRLGPDDAYLITRGLRTLDVRLDKHEKS 268
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES-NKFLSS 357
+ +A +L + +K +L+P + KK SG SG+ K S KF++S
Sbjct: 269 AKQVAEFLSNYKNIK-LLYPHKKDSFNFRMWKKYYSGASGLMGLKIKSKDKNSVIKFVNS 327
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LK+F S GG+ESLA + + +L + LVRL +GLED +DLI DL+
Sbjct: 328 LKLFGYGYSWGGFESLALYQDKREQGN---REYLKLAKDEHLVRLHIGLEDPKDLIDDLK 384
>UniRef50_A7CL93 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme; n=1; Ralstonia
pickettii 12D|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme - Ralstonia
pickettii 12D
Length = 385
Score = 91.9 bits (218), Expect = 8e-18
Identities = 55/180 (30%), Positives = 89/180 (49%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSDV +G+ V + +++ + +G S D +LV R L+TL++R+ +H +
Sbjct: 201 YAAGHSDVCLGSITVRSERLFRQIKTFVSGVGTGVSSDDAFLVLRGLRTLSVRLAEHAQR 260
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFS-FVHVGGLKESNKFLSS 357
L + WL +V ++HP P PQH+ K+ S +G+ + +H L+ + L
Sbjct: 261 GLDLTQWLRGRREVASLVHPAHPEDPQHQRFKRYFSSGNGLLTILLHSQDLERISAMLDG 320
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
LK F + S GG +SL + + V + + RL +GLE E L ADLE
Sbjct: 321 LKHFRIGASWGGTDSLIAIADLTASRIVQPWPPGRYAL-----RLHIGLEPLEPLYADLE 375
>UniRef50_A0JYV8 Cluster: Cystathionine gamma-synthase; n=8;
Actinobacteria (class)|Rep: Cystathionine gamma-synthase
- Arthrobacter sp. (strain FB24)
Length = 387
Score = 91.9 bits (218), Expect = 8e-18
Identities = 57/178 (32%), Positives = 95/178 (53%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
++ GH D MG + +LR ++ G + +P YL++R L TL +R+ + +
Sbjct: 208 FLGGHGDA-MGGVVAAPVEWTTRLRQVRAVTGGILTPWPAYLLHRGLATLPVRVRAQQAT 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ +A L H VK V +PGLP + Q SG + +F + + + + +++
Sbjct: 267 AHKVAAALAGHGLVKAVHYPGLPECDPLGLVGTQMSGPGSLLAF-ELASAEHAERVPAAV 325
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
++ T A SLGG ++L + P+ +TH V A R + SL+RLSVGLED D++ADL
Sbjct: 326 RMITHAVSLGGIDTLIQHPAGLTHRPVAAGARPRA----SLLRLSVGLEDVTDIVADL 379
>UniRef50_A5ZYG7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 91.5 bits (217), Expect = 1e-17
Identities = 54/159 (33%), Positives = 86/159 (54%), Gaps = 1/159 (0%)
Frame = +1
Query: 64 AKLRF-LQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHP 240
AKLR L +MG +P + +L N L+TL +RM++H +++ +A +L V +P
Sbjct: 247 AKLRNGLFRSMGACLAPQNAFLNNLGLETLGLRMQRHCSNAMELAEFLNGLGHGITVSYP 306
Query: 241 GLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPS 420
GL HP HEI KQ G G + + + + L+ LKI L ++G ++L PS
Sbjct: 307 GLKEHPYHEIAAKQFHGGFGAIITLRTESKERAFQILNELKIPWLVSNIGDTKTLVIHPS 366
Query: 421 VMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
A + E++ G+ D ++R+SVG+ED EDL D +
Sbjct: 367 STIAAHLSQEEKELSGVYDDMIRISVGIEDIEDLKEDFK 405
>UniRef50_Q47S97 Cluster: Cystathionine gamma-synthase; n=1;
Thermobifida fusca YX|Rep: Cystathionine gamma-synthase
- Thermobifida fusca (strain YX)
Length = 406
Score = 91.1 bits (216), Expect = 1e-17
Identities = 59/183 (32%), Positives = 93/183 (50%), Gaps = 6/183 (3%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD G A+ ++A ++R + +G + + +L++R L+TL +RM + +
Sbjct: 213 YLGGHSDATGGVAVGRPDLLA-RIREARIDLGPHLAADEAFLLHRGLETLPLRMARQCAT 271
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSGHSG-----VFSFVHVGGLKESN 342
+ A L +HP V V HP LP+H H + +K +G G V + GG +
Sbjct: 272 AAEFAAALAEHPAVARVDHPSLPTHQGHVLARKLFDTGPEGPRYGAVVTVTPRGGREAGI 331
Query: 343 KFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDL 522
F L++ T+A SLGG ++ + TH + E GI VR S+G+ED DL
Sbjct: 332 AFADRLRLATIAPSLGGTHTVVSHVASTTHRQMSDEALHAAGIDPGAVRFSIGVEDPADL 391
Query: 523 IAD 531
IAD
Sbjct: 392 IAD 394
>UniRef50_Q7X137 Cluster: Cystathionine gamma lyase-like protein;
n=1; Pseudomonas fluorescens|Rep: Cystathionine gamma
lyase-like protein - Pseudomonas fluorescens
Length = 381
Score = 91.1 bits (216), Expect = 1e-17
Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 1/179 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +GHSDV+ G +VN+ +I +L + G + +P +L+ RS++T +RME+H +
Sbjct: 191 YFSGHSDVMGGLVLVNNEMIYTRLLEGRFYSGSILAPNSAWLLRRSMQTFNLRMEKHSNT 250
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSG-VFSFVHVGGLKESNKFLSS 357
+ + N+L + P ++ V +P + KQ +G+ G VF + + F SS
Sbjct: 251 TSSMLNYLRELPFIEHVYYP--------RVDGKQLTGYGGIVFVDIRPDLVPFYKTFTSS 302
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
LK F + S+ P +HAS+ +++A +GI LVRL GLE EDL DL
Sbjct: 303 LKWFGTGTGMACVTSMVAQPFSGSHASMTEQEKADMGIEKGLVRLCFGLEALEDLKEDL 361
>UniRef50_Q5K6Y9 Cluster: Cystathionine gamma-lyase, putative; n=1;
Filobasidiella neoformans|Rep: Cystathionine
gamma-lyase, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 466
Score = 91.1 bits (216), Expect = 1e-17
Identities = 47/81 (58%), Positives = 60/81 (74%), Gaps = 1/81 (1%)
Frame = +1
Query: 298 GVFSF-VHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGIT 474
GV +F + G L+++ KF +SL + +LAESLGG ESL E+P MTHAS+P E +LGIT
Sbjct: 378 GVVTFTLKDGTLEQAEKFCTSLNVISLAESLGGVESLIEVPLGMTHASIPKESLEKLGIT 437
Query: 475 DSLVRLSVGLEDTEDLIADLE 537
SLVR SVG+ED EDLI DL+
Sbjct: 438 ASLVRFSVGIEDYEDLIEDLQ 458
Score = 77.4 bits (182), Expect = 2e-13
Identities = 40/87 (45%), Positives = 57/87 (65%), Gaps = 6/87 (6%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGV------IAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRM 162
Y +GHSD+I+G+ V+ + LRFLQN+MG PSP DC+L+ RSLKTL+ RM
Sbjct: 233 YSSGHSDIILGSVTVSPQTARFRPELIKALRFLQNSMGACPSPYDCHLMIRSLKTLSTRM 292
Query: 163 EQHKKSSLIIANWLLKHPKVKDVLHPG 243
+H ++L IA +L P+V +V +PG
Sbjct: 293 IKHGVNALRIAAFLDNQPQVSEVRYPG 319
>UniRef50_Q8NM00 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=1; Corynebacterium glutamicum|Rep:
Cystathionine beta-lyases/cystathionine gamma-synthases
- Corynebacterium glutamicum (Brevibacterium flavum)
Length = 382
Score = 90.2 bits (214), Expect = 3e-17
Identities = 60/178 (33%), Positives = 93/178 (52%), Gaps = 1/178 (0%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
+ GHSD+++G A+ A L ++ G VP ++ +L R L +LA+R+++ + ++
Sbjct: 203 IGGHSDLLLGVAVCKSEHHAQFLATHRHDHGSVPGGLEAFLALRGLYSLAVRLDRAESNA 262
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHE-ITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
++ L HP V V +PGLP PQHE + SG + SF + +++ L SL
Sbjct: 263 AELSRRLNAHPSVTRVNYPGLPDDPQHEKAVRVLPSGCGNMLSFELDATPERTDEILESL 322
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ T A S GG E+ E A V A G+ +L R+SVG+ED EDL DL
Sbjct: 323 SLLTHATSWGGVETAIE-RRTRRDAEVVA------GVPMTLCRVSVGIEDVEDLWEDL 373
>UniRef50_Q7M9C8 Cluster: O-ACETYLHOMOSERINE SULFHYDRYLASE; n=1;
Wolinella succinogenes|Rep: O-ACETYLHOMOSERINE
SULFHYDRYLASE - Wolinella succinogenes
Length = 407
Score = 90.2 bits (214), Expect = 3e-17
Identities = 53/157 (33%), Positives = 92/157 (58%)
Frame = +1
Query: 64 AKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPG 243
A+ QN +G SP + YL + L+T+A+R+E+ +++ +A+WLL P+VK V HP
Sbjct: 248 ARKEVFQN-LGPSLSPHNAYLQSLGLETMALRIERSCQNAQELAHWLLSIPQVKCVNHPS 306
Query: 244 LPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSV 423
LP P + I K+Q + +F + + S +F+ +LK+ A ++ +SL P
Sbjct: 307 LPDSPFYAIAKRQFRYAGSILTF-ELESKEASYRFMDALKLIRRATNIHDNKSLILSPYH 365
Query: 424 MTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ +A E+R +L I+ +++RLSVG+E+ EDL D+
Sbjct: 366 VIYALNSHEERLKLEISPAMMRLSVGIEEIEDLKEDI 402
>UniRef50_A3PXR9 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=7;
Actinomycetales|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Mycobacterium
sp. (strain JLS)
Length = 367
Score = 89.0 bits (211), Expect = 6e-17
Identities = 56/177 (31%), Positives = 87/177 (49%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
++GHSD+I G + + A L + G + P + +LV RSL + +R E+ +++
Sbjct: 198 LSGHSDLIAGYVAGSHPEMMAALETDRLLAGPILGPFEAWLVLRSLGSAGLRFERQCQNA 257
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
L +A L HP V+ V +PGLP P HE+ +Q G+ S V + + +
Sbjct: 258 LAVAMLLRNHPAVRGVRYPGLPEDPAHEVAARQMRRFGGLVS-VELADASAVHALVERSA 316
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+ + S GG H S+ R + D VRLS+G+EDT+DLIADL
Sbjct: 317 LLVASTSFGG-----------IHTSIDRRARWGDPVPDGFVRLSMGIEDTDDLIADL 362
>UniRef50_Q97MT9 Cluster: O-acetylhomoserine sulfhydrylase; n=4;
Clostridiales|Rep: O-acetylhomoserine sulfhydrylase -
Clostridium acetobutylicum
Length = 409
Score = 88.6 bits (210), Expect = 8e-17
Identities = 47/150 (31%), Positives = 91/150 (60%), Gaps = 1/150 (0%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
+G SP + +L ++TL++RM++H ++++ IA++L K KV +V +P L S +++
Sbjct: 255 IGASMSPFNAFLSLTGIETLSLRMKKHCENAMKIASYLEKSDKVTNVNYPNLKSSKYYDL 314
Query: 271 -TKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPA 447
TK G SG+ +F +G + + KFL+ LK+ ++G +++ P+ +
Sbjct: 315 ATKYYADGASGILTF-RLGTKENAYKFLAKLKLILDTTNIGDCKTIIIHPASTICINNTE 373
Query: 448 EQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
E+R ++ + D L+RLSVG+ED ED++ D++
Sbjct: 374 EEREKMAVYDDLLRLSVGIEDIEDILEDID 403
>UniRef50_Q89V23 Cluster: O-acetylhomoserine sulfhydrylase; n=13;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Bradyrhizobium japonicum
Length = 431
Score = 87.4 bits (207), Expect = 2e-16
Identities = 48/148 (32%), Positives = 80/148 (54%), Gaps = 1/148 (0%)
Frame = +1
Query: 94 GIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEIT 273
G SP + + + + ++TL +RM++H +++ + L + V VLHP L H +++
Sbjct: 274 GACLSPTNAFQLLQGVETLGVRMDRHMQNTHSVLEALKSNKAVDWVLHPSLEDHTDYQLA 333
Query: 274 KKQTS-GHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAE 450
K+ G + SF GG KF+ SL++ + ++G ++L P+ TH + AE
Sbjct: 334 KQLLPRGAGSIVSFGIKGGRPAGRKFIESLRMISHLANVGDAKTLVIHPASTTHQQMDAE 393
Query: 451 QRAQLGITDSLVRLSVGLEDTEDLIADL 534
Q GI + LVRLSVG+E D+I DL
Sbjct: 394 QLKAAGIGEELVRLSVGIETASDIIDDL 421
>UniRef50_P06106 Cluster: Protein MET17 [Includes:
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) (OAH
sulfhydrylase) (Homocysteine synthase); O- acetylserine
sulfhydrylase (EC 2.5.1.47) (OAS sulfhydrylase)]; n=107;
cellular organisms|Rep: Protein MET17 [Includes:
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) (OAH
sulfhydrylase) (Homocysteine synthase); O- acetylserine
sulfhydrylase (EC 2.5.1.47) (OAS sulfhydrylase)] -
Saccharomyces cerevisiae (Baker's yeast)
Length = 444
Score = 87.4 bits (207), Expect = 2e-16
Identities = 60/188 (31%), Positives = 99/188 (52%), Gaps = 12/188 (6%)
Frame = +1
Query: 10 GHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLI 189
G+ I A N I L +G + +P +L+ + ++TL++R E+H +++L
Sbjct: 246 GYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALK 305
Query: 190 IANWLLKHPKVKDVLHPGLPSHPQHEITKKQTS-GHSGVFSFVHVGGL----KESNKF-- 348
+A WL + P V V +PGL SH HE KK S G GV SF V L KE++ F
Sbjct: 306 LAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSF-GVKDLPNADKETDPFKL 364
Query: 349 -----LSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDT 513
+ +LK+ + ++G ++L P TH + +++ G+T L+R+SVG+E
Sbjct: 365 SGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFI 424
Query: 514 EDLIADLE 537
+D+IAD +
Sbjct: 425 DDIIADFQ 432
>UniRef50_UPI0000E0F9F5 Cluster: hypothetical protein OM2255_22574;
n=1; alpha proteobacterium HTCC2255|Rep: hypothetical
protein OM2255_22574 - alpha proteobacterium HTCC2255
Length = 411
Score = 87.0 bits (206), Expect = 2e-16
Identities = 51/163 (31%), Positives = 90/163 (55%), Gaps = 1/163 (0%)
Frame = +1
Query: 52 GVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDV 231
G+ + + L++ +P+P ++ L+TL +R ++ +++ +A + HPK+K V
Sbjct: 247 GLTQIRKKGLRDMGATLPAPSASTILV-GLETLDLRYQKACENARKLAQHFMNHPKIKQV 305
Query: 232 LHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAE 411
+PGL SHPQH + + S + + S G ++ +F++ L + + LG +LA
Sbjct: 306 FYPGLASHPQHFLARDHFSSYGALMSIELPEG-EDIIQFINRLNLVICSTHLGDTRTLA- 363
Query: 412 LPSVMT-HASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+P T +R + GITD +VRLS+G+ED +DLIAD E
Sbjct: 364 IPVAQTIFFEATQVERDRTGITDQIVRLSIGIEDVDDLIADFE 406
>UniRef50_Q2C9J3 Cluster: Cystathionine beta-lyase; n=1;
Photobacterium sp. SKA34|Rep: Cystathionine beta-lyase -
Photobacterium sp. SKA34
Length = 150
Score = 85.8 bits (203), Expect = 6e-16
Identities = 53/149 (35%), Positives = 74/149 (49%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
MG+ SP DC+L R L+T +R E+ S+ IA WL H V VLHP LPS + +
Sbjct: 1 MGMYVSPDDCFLALRGLETYELRQEKQSNSAKAIAQWLDNHESVASVLHPALPSSEDNTL 60
Query: 271 TKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAE 450
K + VFSF + + F + F + S GG SL SV + +
Sbjct: 61 YNKYFDNYGSVFSFT-LKDESQIGAFFDTFTKFKIGASYGGTTSLIAYYSVDS-----LK 114
Query: 451 QRAQLGITDSLVRLSVGLEDTEDLIADLE 537
R SL+R+S+GLED++ LI DL+
Sbjct: 115 SRLFTRGDSSLIRISIGLEDSQCLINDLD 143
>UniRef50_Q82YZ5 Cluster: Cystathionine gamma-synthase, putative;
n=1; Enterococcus faecalis|Rep: Cystathionine
gamma-synthase, putative - Enterococcus faecalis
(Streptococcus faecalis)
Length = 395
Score = 85.4 bits (202), Expect = 7e-16
Identities = 49/180 (27%), Positives = 96/180 (53%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD++ GA I ++ A+G V SP + +L R ++T+ +R+ ++
Sbjct: 207 YIGGHSDIVAGAVIGKAALVDQIFEHGHQALGAVNSPFNSWLALRGIRTMPVRLAHQSQA 266
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF-VHVGGLKESNKFLSS 357
+ L K P++ + HP + + Q + +K +G+ +F+ + + F+++
Sbjct: 267 IQTVLLALQKDPRISRLYHPFVGNQQQQALAEKYLTGYGSLFAIDLKDTDFERLKTFVNA 326
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
L + T+ S GG+ESLA LP V ++ A Q+ G++ + +R+ VGLE+ +I D++
Sbjct: 327 LTLVTIGVSWGGFESLA-LP-VFKGNNLAAVQKR--GLSPAHIRMYVGLEEPTSIIEDIQ 382
>UniRef50_Q28LE3 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme; n=2;
Rhodobacteraceae|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme - Jannaschia sp.
(strain CCS1)
Length = 383
Score = 85.4 bits (202), Expect = 7e-16
Identities = 57/180 (31%), Positives = 91/180 (50%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y++GHSD + G + + IA +G +P + +L+ R L+TL +RM QH+ +
Sbjct: 205 YISGHSDTVAGVVVSSHAHIARIRDLTLPLLGAKLAPFEAFLLTRGLRTLKVRMMQHQAT 264
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSL 360
+ + + L P+V+ + PG + P +G SG+ S + + F +
Sbjct: 265 ADLFVDRLAAVPQVRRINSPGANAVP-------GLTGRSGLMS-IEFDDTVDIPAFADAF 316
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQ-LGITDSLVRLSVGLEDTEDLIADLE 537
F L S GG+ESL LP+ + A Q G++ +LVRL++GLED EDL AD E
Sbjct: 317 THFRLGVSWGGFESLV-LPARVALAQAGEHNSLQAFGVSPNLVRLNLGLEDPEDLWADFE 375
>UniRef50_A1I7W3 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: O-acetylhomoserine
aminocarboxypropyltransferase - Candidatus Desulfococcus
oleovorans Hxd3
Length = 419
Score = 84.6 bits (200), Expect = 1e-15
Identities = 51/152 (33%), Positives = 82/152 (53%), Gaps = 5/152 (3%)
Frame = +1
Query: 94 GIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEIT 273
G +P YL + TLA+RME+H +++++A +L P+V V +PGL HP H +
Sbjct: 264 GTTQAPFHSYLTLIGIDTLALRMERHVANAMVVARFLATRPEVAWVNYPGLEDHPCHGLA 323
Query: 274 KKQ--TSGHSGVFSFVHVGGLKESNK---FLSSLKIFTLAESLGGYESLAELPSVMTHAS 438
+Q + G G+ +F GLK+ F++ LK+ +LG +LA P + S
Sbjct: 324 ARQFESKGFGGLLTF----GLKDPAACPGFINRLKLVLHLANLGDCRTLAIHPFSTQYVS 379
Query: 439 VPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
R +L I +VRLSVG+E+ +D+ AD+
Sbjct: 380 FDDATRKKLAIGPEMVRLSVGIENPDDICADI 411
>UniRef50_Q0B5H9 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1; Burkholderia
ambifaria AMMD|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Burkholderia
cepacia (strain ATCC 53795 / AMMD)
Length = 384
Score = 83.8 bits (198), Expect = 2e-15
Identities = 55/180 (30%), Positives = 89/180 (49%), Gaps = 1/180 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH+D ++GAA+ + +++ + G D L R L+TLA+RM++H +S
Sbjct: 208 YIGGHADSMVGAAVFASLDMYERVKNVSRLAGQAVGADDANLALRGLRTLAVRMDRHFQS 267
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFV-HVGGLKESNKFLSS 357
+ +A+WL HP ++ V +P L H + Q SG GVF+ V G + +
Sbjct: 268 ACDVASWLRDHPLIESVYYPPLAGDSGHTAWRAQYSGAGGVFACVLKDSGEEAVRNVIDG 327
Query: 358 LKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ GGYES+A +V + ++GI RLS+GLED + L DL+
Sbjct: 328 FSLIGRGWGWGGYESVA------CPITVSRDDAKRIGI-----RLSIGLEDPDTLRHDLD 376
>UniRef50_P43623 Cluster: Putative cystathionine beta-lyase; n=11;
cellular organisms|Rep: Putative cystathionine
beta-lyase - Saccharomyces cerevisiae (Baker's yeast)
Length = 340
Score = 83.8 bits (198), Expect = 2e-15
Identities = 45/133 (33%), Positives = 71/133 (53%), Gaps = 2/133 (1%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSD+++G A N+ LR +AM ++P DC L R ++TL +R+++ ++
Sbjct: 209 YLGGHSDLLIGLASANEECWPL-LRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERK 267
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKES--NKFLS 354
+L +A WL +V+ VLHP P HE + G SG+FS V G + K +
Sbjct: 268 ALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAGLEKMVE 327
Query: 355 SLKIFTLAESLGG 393
+K+ L S GG
Sbjct: 328 GMKVLQLGFSWGG 340
>UniRef50_Q6W1U5 Cluster: Cystathionine gamma-synthase; n=2;
Proteobacteria|Rep: Cystathionine gamma-synthase -
Rhizobium sp. (strain NGR234)
Length = 425
Score = 83.4 bits (197), Expect = 3e-15
Identities = 58/188 (30%), Positives = 95/188 (50%), Gaps = 9/188 (4%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNA-MGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
++NGH D + G + + K+R +G S + +L+ R + TL R++
Sbjct: 237 FINGHGDAL-GGIVCGRKELVEKIRSRAGVYLGASLSAQNAWLIMRGIDTLFPRLKAMSD 295
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSS 357
S++ IA++L HP V+ V +PGL +HPQH + ++Q G+ +F K + +
Sbjct: 296 SAMRIAHFLRDHPGVRSVTYPGLETHPQHALARRQMRIFGGIVTFQTDDPQKIALRLAER 355
Query: 358 LKIFTLAESLGGYESLAEL--PSVMTHASVPAE------QRAQLGITDSLVRLSVGLEDT 513
L++ A SLG S+ L M +++ E RA G D + RLSVGLE
Sbjct: 356 LRVVHYAFSLGHQRSIVVLLDTKEMMNSTYGLEGPQLDDYRAFAG--DGVFRLSVGLESV 413
Query: 514 EDLIADLE 537
+D+IADL+
Sbjct: 414 DDIIADLD 421
>UniRef50_Q3IV09 Cluster: O-acetylhomoserine sulfhydrylase; n=1;
Rhodobacter sphaeroides 2.4.1|Rep: O-acetylhomoserine
sulfhydrylase - Rhodobacter sphaeroides (strain ATCC
17023 / 2.4.1 / NCIB 8253 / DSM158)
Length = 440
Score = 82.6 bits (195), Expect = 5e-15
Identities = 49/161 (30%), Positives = 87/161 (54%), Gaps = 4/161 (2%)
Frame = +1
Query: 67 KLRFLQ-NAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPG 243
+LRF+ G SP+ +L++++ +TLA+R+++H +S+ +A +L HP+V+ V HP
Sbjct: 266 RLRFVMLRDFGATLSPLSAFLLSQATETLALRIQRHAESARRVATFLDGHPRVRSVCHPT 325
Query: 244 LPSHPQHEITKKQTSGHSGVFSFVHV---GGLKESNKFLSSLKIFTLAESLGGYESLAEL 414
+ + E+ + + G V V GG +F++ L +F + G SLA
Sbjct: 326 IGT--ADEVRRNADTIPGGACGMVSVDIHGGQVAGQRFVAGLTLFRHVATAGSSASLAIH 383
Query: 415 PSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
P + ++R + G+ + VRLS+GLED + LI DL+
Sbjct: 384 PYSTQLRQLTEDERRRTGVPEGFVRLSIGLEDPDMLIDDLQ 424
>UniRef50_Q98KA4 Cluster: Probable cystathionine/methionine
gamma-synthase/lyase; n=3; Alphaproteobacteria|Rep:
Probable cystathionine/methionine gamma-synthase/lyase -
Rhizobium loti (Mesorhizobium loti)
Length = 371
Score = 80.6 bits (190), Expect = 2e-14
Identities = 55/180 (30%), Positives = 89/180 (49%), Gaps = 2/180 (1%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
+NGHSDV+ G D I +K+ + G +P P + +LV+R L+TL +R ++ S+
Sbjct: 198 VNGHSDVLFGHVASRDADIISKVTNWRAMAGGIPGPFEAWLVHRGLETLEVRFDRMCSSA 257
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
IA L +H V+ + PGL P H +++ Q + SF + ++ F+++
Sbjct: 258 ETIAQRLKEHRAVRGLRFPGLNGDPSHNLSRAQMERFGFLISF-ELASEDKAEDFINNCP 316
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLG--ITDSLVRLSVGLEDTEDLIADLE 537
+ A S GG H S AE+R++ G + VRLSVG E E+L +E
Sbjct: 317 LIEAATSFGG-----------VHTS--AERRSKRGDAVPPGFVRLSVGCEPVEELWKAIE 363
>UniRef50_Q5LN68 Cluster: Cys/Met metabolism PLP-dependent enzyme
family protein; n=2; Rhodobacterales|Rep: Cys/Met
metabolism PLP-dependent enzyme family protein -
Silicibacter pomeroyi
Length = 371
Score = 80.2 bits (189), Expect = 3e-14
Identities = 50/175 (28%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Frame = +1
Query: 4 MNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSS 183
M GHSD+++G D + + + G +P P + +L++R L+TL +R ++ +++
Sbjct: 200 MGGHSDLLLGHVASRDAGLVQAIEDWRRISGAIPGPHEAWLLHRGLETLEVRFDRMCRNA 259
Query: 184 LIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLK 363
+A L +H V + PGLP P H + + Q G + +G +++ +F++
Sbjct: 260 EALAPRLARHRAVSALRFPGLPGDPAHNLARAQMQ-RFGFLLSLDLGSEEKAEQFINGCP 318
Query: 364 IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLG--ITDSLVRLSVGLEDTEDL 522
+ A S GG H+S AE+RA+ G +T VRLS+G E E+L
Sbjct: 319 LLRPATSFGG-----------VHSS--AERRARWGDAVTPGFVRLSIGCEPLEEL 360
>UniRef50_UPI0000E4882F Cluster: PREDICTED: hypothetical protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein, partial -
Strongylocentrotus purpuratus
Length = 806
Score = 79.8 bits (188), Expect = 4e-14
Identities = 36/64 (56%), Positives = 42/64 (65%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
YMNGHSDV+MG ND + KL F A G PSP DC+LVNR LKTL +RM QH KS
Sbjct: 743 YMNGHSDVVMGLVACNDDELHKKLHFQLYAAGSCPSPFDCFLVNRGLKTLHVRMRQHYKS 802
Query: 181 SLII 192
+ +
Sbjct: 803 GIAV 806
>UniRef50_UPI0000E46EAD Cluster: PREDICTED: similar to methionine
gamma-lyase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to methionine gamma-lyase -
Strongylocentrotus purpuratus
Length = 364
Score = 79.4 bits (187), Expect = 5e-14
Identities = 40/112 (35%), Positives = 61/112 (54%), Gaps = 1/112 (0%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GH D++ G+ D + L Q +G P ++ R ++TL +RME+H +
Sbjct: 244 YLGGHGDLLGGSMCTKDPELYLFLTEYQRQIGNTMGPFTASILLRGIRTLPLRMEKHSSN 303
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQ-TSGHSGVFSFVHVGGLK 333
+L IA +L HPKV V +PGL SHPQ+++ Q G G+ F GGL+
Sbjct: 304 ALKIAQYLETHPKVARVKYPGLKSHPQYDVAASQMKKGFGGMVIFEMKGGLE 355
>UniRef50_Q181I0 Cluster: Methionine gamma-lyase; n=2; Clostridium
difficile|Rep: Methionine gamma-lyase - Clostridium
difficile (strain 630)
Length = 384
Score = 78.6 bits (185), Expect = 8e-14
Identities = 56/187 (29%), Positives = 98/187 (52%), Gaps = 8/187 (4%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVI-AAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
++NGH D + GA + +I + L G PM +++ R +KTL +RM++H +
Sbjct: 209 FINGHGDTLGGAVAGSKELIDLVRWPSLCCFTGASLPPMSAWMILRGMKTLDMRMKKHCE 268
Query: 178 SSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSG-HSGVFSFVHVGGL------KE 336
+ L +A +L + V+ V +P L SHPQ+E+ K Q +G GV SF G+ +
Sbjct: 269 NGLAVAEFLEEEENVELVKYPALKSHPQYELCKTQMNGLGGGVVSFKLKDGINGLTRDQA 328
Query: 337 SNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTE 516
S + ++SL++ T+A SLG +L ++ ++L+R++VGLE +
Sbjct: 329 SRRLMNSLELATIATSLGEEHTLVQMNG------------------ENLIRIAVGLESSN 370
Query: 517 DLIADLE 537
D+I D +
Sbjct: 371 DIINDFK 377
>UniRef50_UPI00003935FC Cluster: COG2873: O-acetylhomoserine
sulfhydrylase; n=1; Bifidobacterium longum DJO10A|Rep:
COG2873: O-acetylhomoserine sulfhydrylase -
Bifidobacterium longum DJO10A
Length = 114
Score = 77.4 bits (182), Expect = 2e-13
Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 1/104 (0%)
Frame = +1
Query: 229 VLHPGLPSHPQHEITKKQ-TSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESL 405
V + GL PQ+E+ K G + SF GG + + K+F+ ++G SL
Sbjct: 4 VNYSGLGYTPQYELVGKYFPRGVGQILSFQVDGGADSVRRIIDGTKLFSYVPNIGDARSL 63
Query: 406 AELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
P+ +TH VPAE R G++D+L+RLS+GLED DLIADL+
Sbjct: 64 IVDPARITHREVPAEARIAAGVSDNLIRLSIGLEDVNDLIADLD 107
>UniRef50_A5G8H3 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=3; Geobacter|Rep:
O-acetylhomoserine aminocarboxypropyltransferase -
Geobacter uraniumreducens Rf4
Length = 428
Score = 77.0 bits (181), Expect = 3e-13
Identities = 38/155 (24%), Positives = 81/155 (52%)
Frame = +1
Query: 73 RFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPS 252
+ + G +PM+ +L+ ++TL++RME+H ++ +A +L H +V+ V +PGL
Sbjct: 268 KLIHKDFGACAAPMNSFLLAEGVETLSLRMERHCANAQKLAQFLKAHDRVRWVNYPGLED 327
Query: 253 HPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTH 432
P H++ KK G + + +F++ +++ ++G ++L P+
Sbjct: 328 SPHHQVAKKLYGDKFGGVLTFGLADKAAAFRFINGVRLAKNLANIGDAKTLVIHPASTIC 387
Query: 433 ASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
E++ +G+ + +VR+SVG+E D+I D +
Sbjct: 388 CDYGPEEKGLMGVGEEMVRVSVGIEAINDIIEDFD 422
>UniRef50_Q8LAA9 Cluster: Putative uncharacterized protein; n=1;
Arabidopsis thaliana|Rep: Putative uncharacterized
protein - Arabidopsis thaliana (Mouse-ear cress)
Length = 149
Score = 76.6 bits (180), Expect = 3e-13
Identities = 36/79 (45%), Positives = 53/79 (67%)
Frame = +1
Query: 301 VFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDS 480
VFSF+ G + S + + K F++A S G +SL +P M+HAS+PAE R G+T+
Sbjct: 64 VFSFI-TGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTED 122
Query: 481 LVRLSVGLEDTEDLIADLE 537
LVR+S G+ED +DLI+DL+
Sbjct: 123 LVRISAGIEDVDDLISDLD 141
>UniRef50_A4CKV8 Cluster: Cystathionine beta-lyase; n=11;
Bacteroidetes|Rep: Cystathionine beta-lyase -
Robiginitalea biformata HTCC2501
Length = 417
Score = 76.2 bits (179), Expect = 5e-13
Identities = 48/180 (26%), Positives = 100/180 (55%), Gaps = 10/180 (5%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMG-IVPSPMDCYL---VNRSLKTLAIRMEQ 168
++NG SD + GA + D L+ + + G ++ S +D + ++L+TL +R+ Q
Sbjct: 216 FINGSSDAVAGA-VCADSDFCLALKDVNDGAGMLLGSTLDSLRAASILKNLRTLHLRIRQ 274
Query: 169 HKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTS---GHSGVFSFVHVGGLKES 339
H ++ +A + ++ V++PGL SHP H++ ++Q + G G+ + V G +++
Sbjct: 275 HSSNAAYLAG-KFREAGLR-VVYPGLESHPGHQLMQRQMNPDFGFGGILT-VDAGSAEKA 331
Query: 340 NKFLSSLK---IFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLED 510
+ + ++ + LA SLG Y++L P T + +P E++ ++G+ L+R S+GL++
Sbjct: 332 DALMEMMQRENLGYLAVSLGFYKTLFSAPGSSTSSEIPEEEQQEMGLGSGLIRFSIGLDN 391
>UniRef50_Q6F7Q9 Cluster: Putative cystathionine beta-lyase,
PLP-dependent; n=1; Acinetobacter sp. ADP1|Rep: Putative
cystathionine beta-lyase, PLP-dependent - Acinetobacter
sp. (strain ADP1)
Length = 397
Score = 75.4 bits (177), Expect = 8e-13
Identities = 56/183 (30%), Positives = 86/183 (46%), Gaps = 4/183 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +G D++MG+ I D + +L + GI S D + RSL + +R +Q ++
Sbjct: 212 YPSGGGDILMGSVITRDKNLYQQLFKIHANQGICVSGDDTAQIIRSLAHMRLRYQQQAEN 271
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITKK--QTSGHSGVFS--FVHVGGLKESNKF 348
+ + WL + P+ VLHP + P H+ K + +G+ S F L +F
Sbjct: 272 AQKLLEWLQQQPQCIQVLHPAASNSPGHDYWKSICKNGQSAGLVSVIFDPKYDLAAIRRF 331
Query: 349 LSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIA 528
+L +F L S GG SL L + + Q G+ LVR VGLED EDLI
Sbjct: 332 CDALNLFKLGFSWGGPVSLVMLYD-LKQMRILNNTHLQQGL---LVRFCVGLEDPEDLIQ 387
Query: 529 DLE 537
D++
Sbjct: 388 DIQ 390
>UniRef50_A1W861 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=10; cellular
organisms|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Acidovorax sp.
(strain JS42)
Length = 415
Score = 75.4 bits (177), Expect = 8e-13
Identities = 61/190 (32%), Positives = 91/190 (47%), Gaps = 12/190 (6%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y +G DV+MG+ D + +++ +G+ D V R+L ++A+R H +
Sbjct: 222 YPSGGGDVLMGSITTRDEGLHLRIKLTHMRLGLGVGANDVEAVLRALPSMALRYHAHDAA 281
Query: 181 SLIIANWLLKHPKVKDVLHPGLPSHPQHEITK----KQTSGH---SGVFSFVHVGGLKES 339
+ +A W+ P V VLHP LP P H K G +G+FS V ++
Sbjct: 282 ARDLAQWMGLQPAVAQVLHPALPGSPGHAQWKALCGAANGGQGAAAGLFSVVIDARHSQA 341
Query: 340 --NKFLSSLKIFTLAESLGGYESLA---ELPSVMTHASVPAEQRAQLGITDSLVRLSVGL 504
+ F L++F L S GG SL +LPS+ T A+ A R ++VR SVGL
Sbjct: 342 QVDAFCDGLRLFKLGYSWGGPMSLVVPYDLPSMRTGAA--AHLR-----PGTVVRFSVGL 394
Query: 505 EDTEDLIADL 534
E +DL ADL
Sbjct: 395 EAVDDLRADL 404
>UniRef50_Q65SV5 Cluster: Putative uncharacterized protein; n=1;
Mannheimia succiniciproducens MBEL55E|Rep: Putative
uncharacterized protein - Mannheimia succiniciproducens
(strain MBEL55E)
Length = 120
Score = 74.5 bits (175), Expect = 1e-12
Identities = 41/111 (36%), Positives = 63/111 (56%), Gaps = 1/111 (0%)
Frame = +1
Query: 208 KHPKVKDVLHPGLPSHPQHEITKKQT-SGHSGVFSFVHVGGLKESNKFLSSLKIFTLAES 384
+HP V+ V +PGL S +E+ +K T +G GV SF G + + K+L SL+I +
Sbjct: 3 RHPMVERVDYPGLASSKDYELKQKYTPNGLCGVLSFELKGDKQTAMKWLDSLQIISREVH 62
Query: 385 LGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADLE 537
+ S A P+ TH + E+ IT +RLS+G+E+ EDL+ADL+
Sbjct: 63 VADIRSCALHPATSTHRQLSDEEMRAANITPGFIRLSIGIENPEDLLADLQ 113
>UniRef50_Q756K4 Cluster: AER250Cp; n=6; Saccharomycetales|Rep:
AER250Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 374
Score = 74.5 bits (175), Expect = 1e-12
Identities = 57/183 (31%), Positives = 95/183 (51%), Gaps = 5/183 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSD++ G V D +A +LR + +G + ++ YL+ RS++T+ +R+ + S
Sbjct: 199 YFGGHSDLLGGVHAVRDAAVARQLRQDRVYLGTNIANLEAYLLIRSMRTMEMRVVRQSTS 258
Query: 181 SLIIANWLLKHPK-----VKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNK 345
+ + +L H + V H L + P + + G++ VFS + + +++ +
Sbjct: 259 ATKVVAYLESHKAEFGGVLVKVFHSSLQTEPY--VQQYLRGGNAPVFSIL-LRTVEQCKR 315
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
S LK+F A SLGG ESL E ++ + EQ +L+R+SVG E EDLI
Sbjct: 316 LPSLLKLFHHATSLGGVESLIEWRAM---SDTTVEQ--------NLLRISVGCESPEDLI 364
Query: 526 ADL 534
ADL
Sbjct: 365 ADL 367
>UniRef50_Q1ITX7 Cluster: Cystathionine gamma-lyase; n=1;
Acidobacteria bacterium Ellin345|Rep: Cystathionine
gamma-lyase - Acidobacteria bacterium (strain Ellin345)
Length = 459
Score = 74.1 bits (174), Expect = 2e-12
Identities = 61/196 (31%), Positives = 96/196 (48%), Gaps = 26/196 (13%)
Frame = +1
Query: 28 MGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCY-LVNRSLKTLAIRMEQHKKSSLIIANWL 204
MG ++ + L + G SP + ++ L +LA RM +K++ +A WL
Sbjct: 258 MGGVVIGPKSLHNVLLMYRKDFGGSLSPKPAWNVLVYGLPSLAARMANMQKTAQYVAEWL 317
Query: 205 LKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVF---SFVHV------GGLKESNKFLSS 357
+HPKV+ V +PGL S PQ ++ + Q + G F S V+ G + KF++
Sbjct: 318 EQHPKVEKVFYPGLESFPQRDLAETQMVDYRGKFAPGSMVYFTLRDKSGENHAAEKFINY 377
Query: 358 LK----IFTLAESLGGYESLAELPSVMTHAS---VPAEQRAQLG---------ITDSLVR 489
+ TLA SLG ++L E P MTH++ V + + G + +R
Sbjct: 378 VADKGYCITLAVSLGQIKTLIENPYSMTHSAYLAVDTNKAKKNGHGRGCETNRVEPGGIR 437
Query: 490 LSVGLEDTEDLIADLE 537
LS+GLED +D+IADLE
Sbjct: 438 LSIGLEDRDDIIADLE 453
>UniRef50_A1TP30 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme; n=1; Acidovorax
avenae subsp. citrulli AAC00-1|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme - Acidovorax avenae
subsp. citrulli (strain AAC00-1)
Length = 396
Score = 72.9 bits (171), Expect = 4e-12
Identities = 53/178 (29%), Positives = 88/178 (49%), Gaps = 2/178 (1%)
Frame = +1
Query: 7 NGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSL 186
+G +D++MG+ I+ L ++ +G+ SP D YLV R L TL++R + ++SL
Sbjct: 211 SGGADLVMGSVGSVREDISRSLCETRHFLGMHVSPDDIYLVLRGLPTLSLRYAANTEASL 270
Query: 187 IIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGL--KESNKFLSSL 360
+A W + ++ V+HP H+ K+ +G + +FS + ++ FL +L
Sbjct: 271 RLAEWFSEKKEIAAVMHPAFRGSQGHDHWKRYFTGATSLFSIAFDASVETEKIEAFLEAL 330
Query: 361 KIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
+F S GG SL L AS +R+ G + R +GLED DL AD+
Sbjct: 331 TLFHFGFSWGGPTSLVMLYG-RESASTRHFERSHPG-AGCIARFWLGLEDGGDLAADV 386
>UniRef50_A2Z703 Cluster: Putative uncharacterized protein; n=3;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 451
Score = 72.1 bits (169), Expect = 7e-12
Identities = 37/98 (37%), Positives = 58/98 (59%)
Frame = +1
Query: 241 GLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPS 420
G S P H + +Q +G GV SF ++ +F+ +L++ +A SLGG ESL + P+
Sbjct: 347 GWESSPWHGVATRQMAGAGGVVSFEVASDMRGVMRFVDALELPLIATSLGGCESLVQQPA 406
Query: 421 VMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLIADL 534
VM++ E++A+ GI D+ VR S G+E EDL D+
Sbjct: 407 VMSYWGKSEEEKAKNGIKDNFVRFSFGIEKFEDLRDDI 444
>UniRef50_Q64XN5 Cluster: O-acetylhomoserine sulfhydrylase; n=3;
Bacteroides|Rep: O-acetylhomoserine sulfhydrylase -
Bacteroides fragilis
Length = 411
Score = 71.3 bits (167), Expect = 1e-11
Identities = 39/148 (26%), Positives = 78/148 (52%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
+G +P Y+ L+T+ +R + ++ L +A L + P+++ V + GL S+P +E+
Sbjct: 258 LGAYMTPQVAYMQTLGLETMEVRFARQAETCLKLAQCLQELPEIESVNYTGLESNPFYEL 317
Query: 271 TKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAE 450
+ +Q G + + +F++ L+I A +L ++LA P+ + S +
Sbjct: 318 STRQFGSLPGAMLTFDLPSREICFRFINRLRIIRRATNLFDNKTLAIHPASTIYGSFTED 377
Query: 451 QRAQLGITDSLVRLSVGLEDTEDLIADL 534
QR + ++ +RLSVGLE +DL+ D+
Sbjct: 378 QRRGMDVSQKTIRLSVGLERADDLLDDI 405
>UniRef50_A5BR77 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 400
Score = 67.3 bits (157), Expect = 2e-10
Identities = 51/181 (28%), Positives = 94/181 (51%), Gaps = 10/181 (5%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAM---GIVPSPMDCYLVNRSLKTLAIRMEQH 171
+++G +D+I GA ++ + + Q A+ G +P + ++ + L +RM++H
Sbjct: 206 FISGGADIIAGAVCGPAKLVNSMMDLHQGALMLLGPTMNPKVAFELSERIPHLGLRMKEH 265
Query: 172 KKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTS---GHSGVFSFVHVGGLKESN 342
+ +L A +K +K V++PGL HP H + K + G G+ + +G +++N
Sbjct: 266 CRRALEYAT-RMKKLGLK-VIYPGLEGHPDHTVLKSIANLDYGFGGLLC-LDMGTEEKAN 322
Query: 343 KFLSSLKIFT----LAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLED 510
+ ++ L+ T +A SLG YE+L T + + AE++A GI LVR+SVG
Sbjct: 323 RLMNLLQNSTQFGFMAVSLGYYETLMSCSGSSTSSEMNAEEKALAGIXPGLVRMSVGYSG 382
Query: 511 T 513
T
Sbjct: 383 T 383
>UniRef50_A4S3Y0 Cluster: Putative 2nd cystathione gamma synthase;
n=1; Ostreococcus lucimarinus CCE9901|Rep: Putative 2nd
cystathione gamma synthase - Ostreococcus lucimarinus
CCE9901
Length = 386
Score = 66.5 bits (155), Expect = 4e-10
Identities = 56/185 (30%), Positives = 93/185 (50%), Gaps = 6/185 (3%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIA-AKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKK 177
Y+NGH DV+ GA + + ++ + G MD YL++R ++TL +R+ + +
Sbjct: 202 YLNGHGDVVAGALVTRECDDRWQRILHERKLGGATMGSMDAYLLSRGMRTLELRVRRQSE 261
Query: 178 SSLIIANWLLKH-----PKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESN 342
S++ IA+ ++ P VL+PGL Q + T + + H + + + G+ +
Sbjct: 262 SAMWIAHEFEQYLRSRIPHGAIVLYPGL----QTDTTVESKNAHYDIVNRMCPNGVCD-- 315
Query: 343 KFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDL 522
+T A SLGG+ESL E + A P E+ + L+RLSVGLE EDL
Sbjct: 316 -------YWTCATSLGGFESLIEHRYSVECA--PGEKEPH--VPGGLLRLSVGLETKEDL 364
Query: 523 IADLE 537
+A L+
Sbjct: 365 LAGLK 369
>UniRef50_A5KK19 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus torques ATCC 27756|Rep: Putative
uncharacterized protein - Ruminococcus torques ATCC
27756
Length = 388
Score = 65.7 bits (153), Expect = 6e-10
Identities = 35/106 (33%), Positives = 59/106 (55%), Gaps = 2/106 (1%)
Frame = +1
Query: 91 MGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEI 270
MG SP +L+ + +TL++R+E+H +++ + +L HP V+ V HP L HP H++
Sbjct: 271 MGAAISPFAAFLLLQGTETLSLRLERHAENTKKVIEYLNHHPLVEKVNHPLLADHPDHDL 330
Query: 271 TKK-QTSGHSGVFSFVHVGGLKESNKFLSSL-KIFTLAESLGGYES 402
KK +G +F+F GG+KE + S IF+ + G +S
Sbjct: 331 YKKFFKNGGGSIFTFEIKGGIKEDARVYRSFGNIFSFGKCCGCQKS 376
>UniRef50_O42851 Cluster: Uncharacterized trans-sulfuration enzyme
C23A1.14c; n=1; Schizosaccharomyces pombe|Rep:
Uncharacterized trans-sulfuration enzyme C23A1.14c -
Schizosaccharomyces pombe (Fission yeast)
Length = 398
Score = 65.7 bits (153), Expect = 6e-10
Identities = 59/192 (30%), Positives = 86/192 (44%), Gaps = 14/192 (7%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y+ GHSDV+ G D L+ + +G + P +L+ RSL+T +R+ +H ++
Sbjct: 213 YLAGHSDVLAGVTASKDRSKILDLKADRAYLGTILHPQQAFLLLRSLRTFPLRIAKHSEN 272
Query: 181 SLIIANWLLK--------------HPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVH 318
++A L K + +V H L + + + K T GH+ FS V
Sbjct: 273 GFLVAQHLNKLATDEQFATSLGIDSSLILEVYHNSLQT--KEFVAKNLTGGHASCFS-VL 329
Query: 319 VGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSV 498
+ + LK F A SLG ESL E MT + I LVRLS+
Sbjct: 330 LKSDTVAKHLCCELKYFHHATSLGSVESLIEWRR-MTDSK----------IDPRLVRLSI 378
Query: 499 GLEDTEDLIADL 534
G+ED DLIADL
Sbjct: 379 GIEDAADLIADL 390
>UniRef50_Q9SGU9 Cluster: F1N19.23; n=7; Magnoliophyta|Rep: F1N19.23
- Arabidopsis thaliana (Mouse-ear cress)
Length = 441
Score = 64.9 bits (151), Expect = 1e-09
Identities = 46/181 (25%), Positives = 95/181 (52%), Gaps = 10/181 (5%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDC---YLVNRSLKTLAIRMEQH 171
+++G +D+I GA ++ ++ + ++ ++ M+ + ++ + L +RM +H
Sbjct: 249 FISGGADIIAGAVCGSENLVKEMMDLRGGSLMLLGPTMNAKVAFELSERIPHLGLRMREH 308
Query: 172 KKSSLIIANWLLKHPKVKDVLHPGLPSHPQHEITKKQTS---GHSGVFSFVHVGGLKESN 342
+ + A ++ +K V++PGL +HPQH++ K + G+ G+ S + + +++N
Sbjct: 309 SHRAQVYAE-RMRDLGMK-VIYPGLETHPQHKLFKGMVNRDYGYGGLLS-IDMETEEKAN 365
Query: 343 KFLSSLKIFT----LAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLED 510
K ++ L+ T +A SLG YE+L T + + Q+ GI+ LVR+SVG
Sbjct: 366 KLMAYLQNATQFGFMAVSLGYYETLMSCSGSSTSSELDPSQKEAAGISPGLVRMSVGYVG 425
Query: 511 T 513
T
Sbjct: 426 T 426
>UniRef50_A1D936 Cluster: Cystathionine gamma-synthase; n=21;
Ascomycota|Rep: Cystathionine gamma-synthase -
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
3700 / NRRL 181))
Length = 409
Score = 64.1 bits (149), Expect = 2e-09
Identities = 61/194 (31%), Positives = 92/194 (47%), Gaps = 16/194 (8%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSDV+ G A KL + +G V M+ +L RSL+TL IR+++ +
Sbjct: 207 YFGGHSDVLCGVLATQRKDWAKKLFQDRLFLGSVMGNMESWLGVRSLRTLEIRVQRQSSN 266
Query: 181 SLIIANWLLK----------------HPKVKDVLHPGLPSHPQHEITKKQTSGHSGVFSF 312
+ + +WL K ++ V H L + + K+ +G VFS
Sbjct: 267 AANLVSWLDKALRAQNPAPGSDEAVTQAALEQVFHASLQKEDEEWLLKQMPNGFGPVFS- 325
Query: 313 VHVGGLKESNKFLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRL 492
+ + + K S L F A SLGG E+L E + MT A+V ++R L+R+
Sbjct: 326 ITMKEEDYARKLPSKLSFFQHATSLGGVETLIEWRT-MTDATV--DRR--------LLRI 374
Query: 493 SVGLEDTEDLIADL 534
SVGLE+ EDL +DL
Sbjct: 375 SVGLENWEDLKSDL 388
>UniRef50_Q45278 Cluster: Aminotransferase and dihydrorhizobitoxine
synthase; n=8; Proteobacteria|Rep: Aminotransferase and
dihydrorhizobitoxine synthase - Bradyrhizobium japonicum
Length = 806
Score = 63.7 bits (148), Expect = 3e-09
Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 3/137 (2%)
Frame = +1
Query: 55 VIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKSSLIIANWLLKHPKVKDVL 234
++ A++ +L++ G +P + + + L+TL +RM+QH ++ I+A+ L +HPKV+ V
Sbjct: 636 LLKARMTWLRDT-GAAIAPFASFQLIQGLETLPLRMKQHCANARIVADVLKEHPKVRRVF 694
Query: 235 HPGLPSHPQHEI---TKKQTSGHSGVFSFVHVGGLKESNKFLSSLKIFTLAESLGGYESL 405
+PGL E T GH + F V + KF+ ++ + ++G +L
Sbjct: 695 YPGLFEGADRETVDQTLNPAYGHGAMVMF-EVEDEQAGRKFIQNVDLMYHVSNVGDARTL 753
Query: 406 AELPSVMTHASVPAEQR 456
P TH +VP E+R
Sbjct: 754 VTHPVSTTHTTVPREKR 770
>UniRef50_P38716 Cluster: Uncharacterized trans-sulfuration enzyme
YHR112C; n=5; Saccharomycetales|Rep: Uncharacterized
trans-sulfuration enzyme YHR112C - Saccharomyces
cerevisiae (Baker's yeast)
Length = 378
Score = 63.3 bits (147), Expect = 3e-09
Identities = 51/183 (27%), Positives = 86/183 (46%), Gaps = 5/183 (2%)
Frame = +1
Query: 1 YMNGHSDVIMGAAIVNDGVIAAKLRFLQNAMGIVPSPMDCYLVNRSLKTLAIRMEQHKKS 180
Y GHSD++ G +V + + +L+ + +G + ++ +++ RSL+T +R+ + ++
Sbjct: 199 YFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSEN 258
Query: 181 SLIIANWLLKHPK-----VKDVLHPGLPSHPQHEITKKQTSGHSGVFSFVHVGGLKESNK 345
+ + +L H +K + H L + E KKQ G G + + ++ +
Sbjct: 259 ATKLVRFLSDHQSEFDKVLKTIYHSSLQTE---EFVKKQLVGGYGPVFAITLYTKEQCKQ 315
Query: 346 FLSSLKIFTLAESLGGYESLAELPSVMTHASVPAEQRAQLGITDSLVRLSVGLEDTEDLI 525
LK F A SLGG ESL E MT I +L+R+SVG E DLI
Sbjct: 316 LPLKLKYFHHATSLGGIESLVEW-RAMTDPY----------IDQTLIRVSVGCESANDLI 364
Query: 526 ADL 534
DL
Sbjct: 365 KDL 367
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.317 0.133 0.378
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 504,926,871
Number of Sequences: 1657284
Number of extensions: 9230765
Number of successful extensions: 26583
Number of sequences better than 10.0: 297
Number of HSP's better than 10.0 without gapping: 25623
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 26279
length of database: 575,637,011
effective HSP length: 96
effective length of database: 416,537,747
effective search space used: 34156095254
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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