Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0001_H17
(650 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9I9E6 Cluster: Phosphoribosylglycinamide formyltransfe... 120 4e-26
UniRef50_P00967 Cluster: Trifunctional purine biosynthetic prote... 118 2e-25
UniRef50_Q11GW6 Cluster: Phosphoribosylformylglycinamidine cyclo... 111 1e-23
UniRef50_A7SD96 Cluster: Predicted protein; n=1; Nematostella ve... 111 2e-23
UniRef50_Q8UG98 Cluster: Phosphoribosylformylglycinamidine cyclo... 107 3e-22
UniRef50_Q5GT57 Cluster: Phosphoribosylformylglycinamidine cyclo... 104 2e-21
UniRef50_Q4SMD7 Cluster: Chromosome 3 SCAF14553, whole genome sh... 103 3e-21
UniRef50_Q54GJ2 Cluster: Phosphoribosylamine-glycine ligase; n=3... 103 4e-21
UniRef50_P22102 Cluster: Trifunctional purine biosynthetic prote... 103 5e-21
UniRef50_Q92QW2 Cluster: Phosphoribosylformylglycinamidine cyclo... 101 1e-20
UniRef50_Q6AK63 Cluster: Phosphoribosylformylglycinamidine cyclo... 98 2e-19
UniRef50_Q1GSA2 Cluster: Phosphoribosylformylglycinamidine cyclo... 97 2e-19
UniRef50_P07244 Cluster: Bifunctional purine biosynthetic protei... 97 3e-19
UniRef50_Q05728 Cluster: Phosphoribosylformylglycinamidine cyclo... 97 4e-19
UniRef50_Q2GF22 Cluster: Phosphoribosylformylglycinamidine cyclo... 93 7e-18
UniRef50_P20772 Cluster: Bifunctional purine biosynthetic protei... 91 3e-17
UniRef50_A3EU85 Cluster: Phosphoribosylformylglycinamidine cyclo... 90 5e-17
UniRef50_Q7M7P5 Cluster: PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO... 89 6e-17
UniRef50_Q8Y6C3 Cluster: Phosphoribosylformylglycinamidine cyclo... 89 9e-17
UniRef50_O68186 Cluster: Phosphoribosylformylglycinamidine cyclo... 89 1e-16
UniRef50_Q3AUU9 Cluster: Phosphoribosylformylglycinamidine cyclo... 87 3e-16
UniRef50_Q2JL07 Cluster: Phosphoribosylformylglycinamidine cyclo... 85 1e-15
UniRef50_Q01RS7 Cluster: Phosphoribosylformylglycinamidine cyclo... 84 2e-15
UniRef50_Q1V2C1 Cluster: Phosphoribosylformylglycinamidine cyclo... 83 6e-15
UniRef50_Q88U27 Cluster: Phosphoribosylformylglycinamidine cyclo... 83 7e-15
UniRef50_Q20143 Cluster: Putative uncharacterized protein; n=2; ... 83 7e-15
UniRef50_A5UWC7 Cluster: Phosphoribosylformylglycinamidine cyclo... 82 1e-14
UniRef50_Q18CW2 Cluster: Phosphoribosylformylglycinamidine cyclo... 81 2e-14
UniRef50_UPI00015BCC94 Cluster: UPI00015BCC94 related cluster; n... 81 2e-14
UniRef50_Q3AMJ2 Cluster: Phosphoribosylformylglycinamidine cyclo... 81 2e-14
UniRef50_Q8XW52 Cluster: Phosphoribosylformylglycinamidine cyclo... 81 2e-14
UniRef50_A0NKK8 Cluster: Phosphoribosylformylglycinamidine cyclo... 79 9e-14
UniRef50_Q1VGN1 Cluster: Phosphoribosylaminoimidazole synthetase... 77 3e-13
UniRef50_Q1IM88 Cluster: Phosphoribosylformylglycinamidine cyclo... 76 8e-13
UniRef50_Q8KG74 Cluster: Phosphoribosylformylglycinamidine cyclo... 74 3e-12
UniRef50_A0NAS3 Cluster: ENSANGP00000030290; n=1; Anopheles gamb... 73 5e-12
UniRef50_A7C0T2 Cluster: Phosphoribosylformylglycinamidine cyclo... 73 8e-12
UniRef50_A4EBR4 Cluster: Phosphoribosylformylglycinamidine cyclo... 72 1e-11
UniRef50_A5FPS3 Cluster: Phosphoribosylformylglycinamidine cyclo... 71 2e-11
UniRef50_Q7UI59 Cluster: Phosphoribosylformylglycinamidine cyclo... 70 4e-11
UniRef50_Q8F242 Cluster: Phosphoribosylformylglycinamidine cyclo... 70 4e-11
UniRef50_UPI00006A1DFE Cluster: Trifunctional purine biosyntheti... 69 1e-10
UniRef50_Q6MIZ3 Cluster: Phosphoribosylformylglycinamidine cyclo... 69 1e-10
UniRef50_A6PTZ2 Cluster: Phosphoribosylformylglycinamidine cyclo... 68 2e-10
UniRef50_Q73N89 Cluster: Phosphoribosylformylglycinamidine cyclo... 67 3e-10
UniRef50_Q8PX06 Cluster: Phosphoribosylformylglycinamidine cyclo... 66 5e-10
UniRef50_Q83FJ9 Cluster: Phosphoribosylformylglycinamidine cyclo... 65 2e-09
UniRef50_Q03Y87 Cluster: Phosphoribosylformylglycinamidine cyclo... 64 2e-09
UniRef50_A4GJ93 Cluster: Phosphoribosylformylglycinamidine cyclo... 63 6e-09
UniRef50_A4M895 Cluster: Phosphoribosylformylglycinamidine cyclo... 62 1e-08
UniRef50_Q9RUJ2 Cluster: Phosphoribosylformylglycinamidine cyclo... 61 2e-08
UniRef50_Q57656 Cluster: Phosphoribosylformylglycinamidine cyclo... 60 5e-08
UniRef50_Q5ZUW5 Cluster: Phosphoribosylformylglycinamidine cyclo... 58 2e-07
UniRef50_Q9UY56 Cluster: Phosphoribosylformylglycinamidine cyclo... 58 2e-07
UniRef50_Q9X0X8 Cluster: Phosphoribosylformylglycinamidine cyclo... 56 6e-07
UniRef50_A2SPR4 Cluster: Phosphoribosylformylglycinamidine cyclo... 55 2e-06
UniRef50_A7DS92 Cluster: Phosphoribosylformylglycinamidine cyclo... 54 2e-06
UniRef50_Q9UX29 Cluster: Phosphoribosylformylglycinamidine cyclo... 51 2e-05
UniRef50_O27272 Cluster: Phosphoribosylformylglycinamidine cyclo... 51 3e-05
UniRef50_Q58MH8 Cluster: Putative uncharacterized protein; n=1; ... 50 5e-05
UniRef50_A0RWR1 Cluster: Phosphoribosylformylglycinamidine cyclo... 50 5e-05
UniRef50_Q97CD7 Cluster: Phosphoribosylformylglycinamidine cyclo... 50 6e-05
UniRef50_Q8TW12 Cluster: Phosphoribosylformylglycinamidine cyclo... 50 6e-05
UniRef50_P40178 Cluster: Putative phosphoribosylformylglycinamid... 48 1e-04
UniRef50_Q5V4T0 Cluster: Phosphoribosylformylglycinamidine cyclo... 45 0.002
UniRef50_A5D6I8 Cluster: Phosphoribosylaminoimidazole synthetase... 43 0.006
UniRef50_Q8YRC3 Cluster: Phosphoribosylformylglycinamidine cyclo... 42 0.010
UniRef50_A7D3C3 Cluster: Phosphoribosylformylglycinamidine cyclo... 42 0.010
UniRef50_A3H6Y1 Cluster: Phosphoribosylformylglycinamidine cyclo... 42 0.010
UniRef50_Q649H9 Cluster: Phosphoribosylformylglycinamidine cyclo... 40 0.039
UniRef50_Q1VKG8 Cluster: Phosphoribosylformylglycinamidine cyclo... 40 0.052
UniRef50_UPI00015BAB1B Cluster: phosphoribosylformylglycinamidin... 36 0.84
UniRef50_Q0YFG6 Cluster: Phosphoribosylformylglycinamidine cyclo... 36 0.84
UniRef50_A1RQR1 Cluster: Phosphoribosylformylglycinamidine cyclo... 34 2.6
UniRef50_Q7MXT4 Cluster: Phosphoribosylformylglycinamidine cyclo... 34 3.4
UniRef50_Q8ZZK0 Cluster: Phosphoribosylformylglycinamidine cyclo... 33 5.9
>UniRef50_Q9I9E6 Cluster: Phosphoribosylglycinamide
formyltransferase; n=12; Euteleostomi|Rep:
Phosphoribosylglycinamide formyltransferase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1017
Score = 120 bits (288), Expect = 4e-26
Identities = 53/116 (45%), Positives = 76/116 (65%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA SV+ GIA+ C+ ETAEMPG+Y PG YD+AGF +G VERS +LPR
Sbjct: 548 VAASVIGGIADACQMAGCALLGGETAEMPGVYPPGEYDLAGFCVGAVERSALLPRLKDIS 607
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G+HSNGFSL+ +++++GL ++ APF + G T+G+ L+ PT+IY
Sbjct: 608 EGDLLLGVSSSGIHSNGFSLVRTILERSGLNISSPAPFGRPGQTIGDVLLTPTKIY 663
Score = 63.3 bits (147), Expect = 5e-09
Identities = 30/78 (38%), Positives = 47/78 (60%), Gaps = 1/78 (1%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSY-GAMV 563
L+A W + PVF+W+ G V + E RTFNCG+G V++VS D V+ ++++ + +
Sbjct: 703 LDACRWRIPPVFSWLQQQGGVCEQEFCRTFNCGLGAVLVVSKADAQRVLRLLQAHEESWI 762
Query: 564 IGSVQARPPHGAPVLVDN 617
IGS+ R P V+V N
Sbjct: 763 IGSLTHRHPGAESVVVRN 780
>UniRef50_P00967 Cluster: Trifunctional purine biosynthetic protein
adenosine-3 [Includes: Phosphoribosylamine--glycine
ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide
synthetase) (Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase); Phosphoribosylglycinamide
formyltransferase (EC 2.1.2.2) (GART) (GAR
transformylase) (5'-phosphoribosylglycinamide
transformylase)]; n=13; cellular organisms|Rep:
Trifunctional purine biosynthetic protein adenosine-3
[Includes: Phosphoribosylamine--glycine ligase (EC
6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase)
(Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase); Phosphoribosylglycinamide
formyltransferase (EC 2.1.2.2) (GART) (GAR
transformylase) (5'-phosphoribosylglycinamide
transformylase)] - Drosophila melanogaster (Fruit fly)
Length = 1353
Score = 118 bits (283), Expect = 2e-25
Identities = 58/116 (50%), Positives = 77/116 (66%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A+ V +G+ EG RQ +A +P +YEP VYD+AGFALG+ E + ILP
Sbjct: 904 LAKGVHSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLAEIQ 963
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+GVHSNGFSL+H ++K+ GL L+DKAPFS + TLGEEL+ PT+IY
Sbjct: 964 PGDVLIGLPSSGVHSNGFSLVHAVLKRVGLGLHDKAPFSDK--TLGEELLVPTKIY 1017
Score = 90.2 bits (214), Expect = 4e-17
Identities = 44/118 (37%), Positives = 67/118 (56%), Gaps = 2/118 (1%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A ++ G+A+GCR ETAEMP +Y PG +D+AG+ +G+VE S ILPR
Sbjct: 554 LAAQLVKGMADGCRDARCALVGGETAEMPSLYAPGQHDMAGYCVGIVEHSRILPRFDLYQ 613
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPF--SQEGLTLGEELIKPTRIY 348
LPS+G+H GF+ I + + + L +++P +GLTL L PT++Y
Sbjct: 614 PGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRERSPVDGGDDGLTLAHVLATPTQLY 671
Score = 75.8 bits (178), Expect = 8e-13
Identities = 37/90 (41%), Positives = 59/90 (65%), Gaps = 2/90 (2%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMR-SYGAMV 563
L+A+ + L PVFAW++ AG + E+ RT+NCG+GMV++V+P + DV+ +R A V
Sbjct: 1059 LDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPTEVEDVLKELRYPQRAAV 1118
Query: 564 IGSVQAR-PPHGAPVLVDNFASGIDLTRRM 650
+G V AR P + V+V NF + + T++M
Sbjct: 1119 VGEVVARKDPKKSQVVVQNFEASLARTQKM 1148
Score = 40.3 bits (90), Expect = 0.039
Identities = 25/74 (33%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSVQARPP-H 593
+F W++ + +L NCGIGMV+I+ P+ S+ GA V+G +Q R
Sbjct: 721 IFGWLAGKLKLSAQTILERHNCGIGMVLIL-PQSSQLWRTSLP--GAKVLGVLQRRSKVS 777
Query: 594 GAPVLVDNFASGID 635
G+PV V NF ++
Sbjct: 778 GSPVQVRNFVEQLE 791
>UniRef50_Q11GW6 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=21; cellular organisms|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Mesorhizobium sp. (strain BNC1)
Length = 368
Score = 111 bits (267), Expect = 1e-23
Identities = 56/113 (49%), Positives = 71/113 (62%)
Frame = +1
Query: 10 SVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXX 189
+++AGIAEGCRQ ETAEMPGMY G YD+AGFA+G ER +LP
Sbjct: 137 AIVAGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERGRLLP-TNDIVEGD 195
Query: 190 XXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S GVHSNGFSL+ ++++ +GL ND APF + +L E L+ PTRIY
Sbjct: 196 VILGLASTGVHSNGFSLVRRIVEVSGLDWNDPAPFDSD-RSLAEALLTPTRIY 247
Score = 56.4 bits (130), Expect = 6e-07
Identities = 26/63 (41%), Positives = 38/63 (60%), Gaps = 2/63 (3%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSVQARP 587
PVF+W+++ G V EMLRTFNCGIGM+ +V+ A V ++ G ++GS+ R
Sbjct: 297 PVFSWLAERGGVAAQEMLRTFNCGIGMIAVVAAGQAAQVAAVLQKEGEHVEILGSIVPRR 356
Query: 588 PHG 596
G
Sbjct: 357 DKG 359
>UniRef50_A7SD96 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1022
Score = 111 bits (266), Expect = 2e-23
Identities = 57/121 (47%), Positives = 73/121 (60%), Gaps = 5/121 (4%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA+ V+ G+AEGC Q ETAEMPGMY+ G YDIAGFA+G VER +LPR
Sbjct: 548 VAKEVVRGVAEGCSQAGCALIGGETAEMPGMYQNGEYDIAGFAVGAVEREQVLPRIQAIK 607
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFS-----QEGLTLGEELIKPTRI 345
L S+G+HSNGFSL+ ++++ GL + APF Q +LG L+ PTRI
Sbjct: 608 TGDVLIGLASSGIHSNGFSLVRRVIEAAGLEFSCPAPFPTTQGVQSMTSLGMALLAPTRI 667
Query: 346 Y 348
Y
Sbjct: 668 Y 668
Score = 64.9 bits (151), Expect = 2e-09
Identities = 33/65 (50%), Positives = 41/65 (63%), Gaps = 2/65 (3%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV- 563
L+A+ W + PVF WI G V EM+RTFNCGIG V+IV D A V++S+R G V
Sbjct: 710 LDANTWKIQPVFGWIWSQGQVATTEMVRTFNCGIGGVLIVEGSDAAFVLDSLRDAGETVW 769
Query: 564 -IGSV 575
IG V
Sbjct: 770 SIGQV 774
>UniRef50_Q8UG98 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=17; Proteobacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Length = 357
Score = 107 bits (256), Expect = 3e-22
Identities = 54/113 (47%), Positives = 71/113 (62%)
Frame = +1
Query: 10 SVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXX 189
++++GIA GCR+ ETAEMPGMY G YD+AGFA+G ER +LP
Sbjct: 124 AIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLAGFAVGAAERGQLLP-AGDIAEGD 182
Query: 190 XXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNGFSL+ K++ +GL + APF+ +G LGE L+ PTRIY
Sbjct: 183 VILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFA-DGKKLGEALLTPTRIY 234
Score = 58.8 bits (136), Expect = 1e-07
Identities = 27/58 (46%), Positives = 39/58 (67%), Gaps = 2/58 (3%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV--IGSVQAR 584
VF+W++ G VE EMLRTFNCG+GM+V+VS E+ V ++ + G V +G + AR
Sbjct: 285 VFSWLAKTGGVEAHEMLRTFNCGVGMIVVVSAENATKVTEALTAEGETVFPLGRMVAR 342
>UniRef50_Q5GT57 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=5; Rickettsiales|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Wolbachia sp. subsp. Brugia malayi (strain TRS)
Length = 346
Score = 104 bits (250), Expect = 2e-21
Identities = 52/116 (44%), Positives = 70/116 (60%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V SV+ GI EGC+Q ETAEMPGMY YD+AGF +GVV++S ILP
Sbjct: 118 VLLSVVQGITEGCKQAKITLVGGETAEMPGMYGNNHYDLAGFVVGVVDKSKILPNYGVMR 177
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+HSNGFSL+ + + G++ ND +P+ + GE L+KPT+IY
Sbjct: 178 AGDYIVGLESSGIHSNGFSLVRHIFEDLGISYNDLSPWDNQ--LWGEVLLKPTKIY 231
Score = 58.0 bits (134), Expect = 2e-07
Identities = 23/49 (46%), Positives = 32/49 (65%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV 563
+F W++ G VE EMLRTFNCGIGM++I+ PE+ V N + G +
Sbjct: 279 IFLWLTKEGKVEKREMLRTFNCGIGMILIIDPENMQGVKNHFQKLGEKI 327
>UniRef50_Q4SMD7 Cluster: Chromosome 3 SCAF14553, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 3
SCAF14553, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1036
Score = 103 bits (248), Expect = 3e-21
Identities = 46/93 (49%), Positives = 63/93 (67%)
Frame = +1
Query: 70 ETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXXXLPSNGVHSNGFSLIHK 249
ETAEMPG+Y PG YD+AGF +G VER +LPR + S+GVHSNGFSL+ K
Sbjct: 574 ETAEMPGVYGPGEYDLAGFCVGAVERGALLPRISDISEGDLLIGVASSGVHSNGFSLVRK 633
Query: 250 LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
++++ GL+ + +PF G T+GE L+ PT+IY
Sbjct: 634 VLERAGLSYSSPSPFGASGQTIGEVLLTPTKIY 666
Score = 69.3 bits (162), Expect = 7e-11
Identities = 30/78 (38%), Positives = 50/78 (64%), Gaps = 1/78 (1%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRS-YGAMV 563
++A W + PVF+W+ G + + EM RTFNCG+G V++VSP D +++ +R+ A +
Sbjct: 706 IDASQWSVPPVFSWLYKEGGLSELEMARTFNCGLGAVLVVSPVDAQMILHQLRAEEQAWI 765
Query: 564 IGSVQARPPHGAPVLVDN 617
+GS+ + P PV+V N
Sbjct: 766 VGSLVRKQPGAEPVMVRN 783
>UniRef50_Q54GJ2 Cluster: Phosphoribosylamine-glycine ligase; n=3;
cellular organisms|Rep: Phosphoribosylamine-glycine
ligase - Dictyostelium discoideum AX4
Length = 815
Score = 103 bits (247), Expect = 4e-21
Identities = 55/118 (46%), Positives = 72/118 (61%), Gaps = 2/118 (1%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA V++GIA GC++ ETAEMPGMY+ G YD+AGF++G VER +LP
Sbjct: 581 VATQVVSGIARGCKESGCALIGGETAEMPGMYKDGEYDLAGFSVGAVERDQMLP--SNIQ 638
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLM--KKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNG+SL+ L+ K GLT N APF TLG+ L+ PT++Y
Sbjct: 639 EGNILLGLASSGVHSNGYSLVRYLIETKSGGLTYNSIAPF-DSSKTLGQVLLTPTKLY 695
Score = 52.8 bits (121), Expect = 7e-06
Identities = 20/49 (40%), Positives = 34/49 (69%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRS 548
W + P+F ++ + G +E +E+L+TFN GIGM++IVSP+ + S+ S
Sbjct: 740 WEILPIFKYLVELGNMETEELLKTFNSGIGMILIVSPDKVDSITKSLES 788
>UniRef50_P22102 Cluster: Trifunctional purine biosynthetic protein
adenosine-3 [Includes: Phosphoribosylamine--glycine
ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide
synthetase) (Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase); Phosphoribosylglycinamide
formyltransferase (EC 2.1.2.2) (GART) (GAR
transformylase) (5'-phosphoribosylglycinamide
transformylase)]; n=133; cellular organisms|Rep:
Trifunctional purine biosynthetic protein adenosine-3
[Includes: Phosphoribosylamine--glycine ligase (EC
6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase)
(Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase); Phosphoribosylglycinamide
formyltransferase (EC 2.1.2.2) (GART) (GAR
transformylase) (5'-phosphoribosylglycinamide
transformylase)] - Homo sapiens (Human)
Length = 1010
Score = 103 bits (246), Expect = 5e-21
Identities = 51/116 (43%), Positives = 68/116 (58%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V +V+AGIA+ C + ETAEMP MY PG YD+AGFA+G +ER LP
Sbjct: 547 VTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPHLERIT 606
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G+HSNGFSL+ K++ K+ L + AP TLG+ L+ PTRIY
Sbjct: 607 EGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIY 662
Score = 65.3 bits (152), Expect = 1e-09
Identities = 31/86 (36%), Positives = 48/86 (55%), Gaps = 2/86 (2%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSY--GAM 560
L+A W + VF+W+ G + ++EM RTFNCG+G V++VS E ++ ++ + A
Sbjct: 702 LDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAW 761
Query: 561 VIGSVQARPPHGAPVLVDNFASGIDL 638
VIGSV AR V V N + +
Sbjct: 762 VIGSVVARAEGSPRVKVKNLIESMQI 787
>UniRef50_Q92QW2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=190; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 356
Score = 101 bits (243), Expect = 1e-20
Identities = 54/113 (47%), Positives = 70/113 (61%)
Frame = +1
Query: 10 SVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXX 189
+++AGIA GCR+ ETAEMPGMY G YD+AGFA+G ER +LP
Sbjct: 124 AIVAGIAAGCREAGCALIGGETAEMPGMYSGGDYDLAGFAVGAAERGQLLP-AGDIAEGD 182
Query: 190 XXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNG+SL+ K++ +GL + APF EG TL + L+ PTRIY
Sbjct: 183 VILGLASSGVHSNGYSLVRKIVSLSGLAWDAPAPFG-EG-TLADLLMTPTRIY 233
Score = 51.2 bits (117), Expect = 2e-05
Identities = 26/64 (40%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV--IGSVQARPP 590
VF+W++ G V +EMLRTFNCG+GM+ +V + V + G V +G + AR
Sbjct: 284 VFSWLAKTGGVAANEMLRTFNCGVGMIAVVPASEAEKVAAVLAGEGETVFTLGRMVAR-A 342
Query: 591 HGAP 602
GAP
Sbjct: 343 EGAP 346
>UniRef50_Q6AK63 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=5; Proteobacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Desulfotalea psychrophila
Length = 356
Score = 97.9 bits (233), Expect = 2e-19
Identities = 53/117 (45%), Positives = 69/117 (58%), Gaps = 1/117 (0%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA V+ GIAEGC+Q ETAEMPG+Y+ YD+AGF G+V+R I+
Sbjct: 122 VATEVVKGIAEGCKQAGCSLVGGETAEMPGLYQGSDYDLAGFVTGIVDRDSIID-GSDVR 180
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKL-MKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNG+SL+ K+ N ++ D + G TLGEEL+KPTRIY
Sbjct: 181 SGNKIIGLASSGVHSNGYSLVRKICFDDNDYSVEDH--IEELGSTLGEELLKPTRIY 235
Score = 52.0 bits (119), Expect = 1e-05
Identities = 23/66 (34%), Positives = 40/66 (60%), Gaps = 2/66 (3%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AM 560
L A W + +F ++ + G V +EM RTFN G+G++VIV+ + D+++ + G A
Sbjct: 275 LQAGSWDVPAIFTFLEEKGKVPREEMYRTFNMGVGLLVIVAEDKAEDILHHFEALGEKAS 334
Query: 561 VIGSVQ 578
+IG +Q
Sbjct: 335 IIGEIQ 340
>UniRef50_Q1GSA2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=77; cellular organisms|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 368
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/116 (46%), Positives = 67/116 (57%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA +V+A IAEGC+Q ETAEMPGMY G YD+AGF +G VER +L
Sbjct: 123 VATAVVASIAEGCKQAGCALIGGETAEMPGMYSDGDYDLAGFCVGAVERDRVL-TSDKVA 181
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNGFSL+ +L G L+ A F Q L + + L+ PTRIY
Sbjct: 182 AGDVILGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDQTVLLI-DALMAPTRIY 236
Score = 53.2 bits (122), Expect = 5e-06
Identities = 24/59 (40%), Positives = 36/59 (61%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV 563
++A W + A++ G +E +EM RTFNCGIGM V+V+ D ADV ++ + G V
Sbjct: 276 VDADSWEQPRLMAFLQAQGNIEPEEMARTFNCGIGMAVVVAEADVADVTAALEAVGETV 334
>UniRef50_P07244 Cluster: Bifunctional purine biosynthetic protein
ADE5,7 [Includes: Phosphoribosylamine--glycine ligase
(EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide
synthetase) (Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase)]; n=12; cellular
organisms|Rep: Bifunctional purine biosynthetic protein
ADE5,7 [Includes: Phosphoribosylamine--glycine ligase
(EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide
synthetase) (Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase)] - Saccharomyces cerevisiae
(Baker's yeast)
Length = 802
Score = 97.1 bits (231), Expect = 3e-19
Identities = 50/116 (43%), Positives = 67/116 (57%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA ++G+A GC Q ET+EMPGMY PG YD G A+G V R ILP+
Sbjct: 565 VASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKINEMA 624
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNGFSL+ K+++ L + P+ E TLGE +++PT+IY
Sbjct: 625 AGDVLLGLASSGVHSNGFSLVRKIIQHVALPWDAPCPW-DESKTLGEGILEPTKIY 679
Score = 61.3 bits (142), Expect = 2e-08
Identities = 29/74 (39%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV--IGSV 575
W + VF W AG V D++LRTFN G+GMV+IV E+ V +S+ G ++ +GS+
Sbjct: 724 WEVPRVFKWFGQAGNVPHDDILRTFNMGVGMVLIVKRENVKAVCDSLTEEGEIIWELGSL 783
Query: 576 QARPPHGAPVLVDN 617
Q RP +++N
Sbjct: 784 QERPKDAPGCVIEN 797
>UniRef50_Q05728 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase, chloroplast precursor; n=14; cellular
organisms|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase, chloroplast precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 389
Score = 96.7 bits (230), Expect = 4e-19
Identities = 48/116 (41%), Positives = 69/116 (59%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A V+ GI EGCRQ ETAEMP Y G YD++GFA+G+V+++ ++
Sbjct: 164 LAEKVIKGIVEGCRQSECALLGGETAEMPDFYAEGEYDLSGFAVGIVKKTSVI-NGKNIV 222
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+GVHSNGFSL+ +++ ++ L+L D P TLG+ L+ PT IY
Sbjct: 223 AGDVLIGLPSSGVHSNGFSLVRRVLARSNLSLKDALPGGSS--TLGDALMAPTVIY 276
Score = 63.3 bits (147), Expect = 5e-09
Identities = 28/60 (46%), Positives = 39/60 (65%), Gaps = 2/60 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRS--YGAMVIGSV 575
W L P+F WI G +ED EM RTFN GIGMV++VSPE + ++ +++ Y A +G V
Sbjct: 321 WELPPLFKWIQQTGRIEDSEMRRTFNLGIGMVMVVSPEAASRILEEVKNGDYVAYRVGEV 380
>UniRef50_Q2GF22 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Neorickettsia sennetsu str.
Miyayama|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase - Neorickettsia sennetsu (strain Miyayama)
Length = 322
Score = 92.7 bits (220), Expect = 7e-18
Identities = 51/116 (43%), Positives = 69/116 (59%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VAR+V++GI GCR+ ETAEMPG+Y G YD+AGFA+G+VE+ ILP+
Sbjct: 115 VARAVISGILVGCREASMSLVGGETAEMPGLYSAGEYDLAGFAVGIVEKEEILPQ--NVT 172
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G H+NGFSLI K + L++ F + T GE L+ PT+IY
Sbjct: 173 KGDILIGLKSSGFHANGFSLIRKTF--SSLSIKYSTLFDKR--TWGEILLTPTKIY 224
Score = 48.8 bits (111), Expect = 1e-04
Identities = 21/54 (38%), Positives = 36/54 (66%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSVQ 578
+F W+ G + +EML TFNCGIGMV++V+ E A+ ++ A++IG+++
Sbjct: 270 IFKWLMLNGNIPQEEMLTTFNCGIGMVLVVA-EQNAEFVSETLGEEALIIGNLK 322
>UniRef50_P20772 Cluster: Bifunctional purine biosynthetic protein
ADE1 [Includes: Phosphoribosylamine--glycine ligase (EC
6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase)
(Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase)]; n=20; cellular
organisms|Rep: Bifunctional purine biosynthetic protein
ADE1 [Includes: Phosphoribosylamine--glycine ligase (EC
6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase)
(Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole
synthetase) (AIR synthase)] - Schizosaccharomyces pombe
(Fission yeast)
Length = 788
Score = 90.6 bits (215), Expect = 3e-17
Identities = 44/116 (37%), Positives = 66/116 (56%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V+ S + G+ +GC+Q ET+EMPG+Y G YD G ++G V R ILP+
Sbjct: 549 VSTSFVEGVVKGCKQAGCALVGGETSEMPGLYHDGHYDANGTSVGAVSRDDILPKPESFS 608
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+GVHSNG+SL+ K+++ + L P+ + + LG+ L+ PTRIY
Sbjct: 609 KGDILLGLASDGVHSNGYSLVRKIVEYSDLEYTSVCPW-DKNVRLGDSLLIPTRIY 663
Score = 57.2 bits (132), Expect = 3e-07
Identities = 26/54 (48%), Positives = 32/54 (59%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV 563
W + VF W+ DAG V +M RTFN GIGMVV V+ ED + M + S G V
Sbjct: 708 WEVPEVFKWLKDAGNVPISDMARTFNMGIGMVVAVASEDAEETMKELTSVGETV 761
>UniRef50_A3EU85 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Leptospirillum sp. Group II UBA|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Leptospirillum sp. Group II UBA
Length = 350
Score = 89.8 bits (213), Expect = 5e-17
Identities = 47/117 (40%), Positives = 68/117 (58%), Gaps = 1/117 (0%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V + + +GIAEGCRQ ETAEMPG+Y+ +D+AGF +G+ +R I+
Sbjct: 119 VGKRIFSGIAEGCRQAGAALLGGETAEMPGVYQDADFDLAGFVVGIADREKIVD-GRKIG 177
Query: 181 XXXXXXXLPSNGVHSNGFSLIHK-LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS G+HSNGFSL+ K L+++ G++ D+ +S G L +PTRIY
Sbjct: 178 LGHRLYGLPSTGIHSNGFSLVRKVLIEERGISPGDRPEWS-PGEDWSHILTRPTRIY 233
Score = 41.9 bits (94), Expect = 0.013
Identities = 20/43 (46%), Positives = 24/43 (55%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPE 515
+N W PVF I AG V EM + FN GIG+VV+V E
Sbjct: 273 INPRAWEKPPVFQEIQKAGKVTTREMFQVFNMGIGLVVVVPSE 315
>UniRef50_Q7M7P5 Cluster: PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE ,; n=6; Campylobacterales|Rep:
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE , -
Wolinella succinogenes
Length = 336
Score = 89.4 bits (212), Expect = 6e-17
Identities = 52/116 (44%), Positives = 65/116 (56%), Gaps = 1/116 (0%)
Frame = +1
Query: 4 ARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXX 183
A V+ GIAEGC+Q ETAEMPGMY +D+AGFA+G+ ERS + R
Sbjct: 120 ALQVIKGIAEGCKQAECALIGGETAEMPGMYHAKDFDLAGFAVGIAERSDV-ERETQTQK 178
Query: 184 XXXXXXLPSNGVHSNGFSLIHK-LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+G HSNG+SLI K L + G+ D G L E L++PTRIY
Sbjct: 179 GDLLVALPSSGAHSNGYSLIRKILFETRGMKFED----DFLGRPLIETLLEPTRIY 230
Score = 34.7 bits (76), Expect = 1.9
Identities = 19/55 (34%), Positives = 30/55 (54%)
Frame = +3
Query: 411 HPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSV 575
HP+F + + VE+ E RTFN G GM++ V E +V+ G +++G V
Sbjct: 276 HPLFDLLKEH--VEEKEAYRTFNMGTGMILCVPQEHLKEVLEKS---GGVLVGEV 325
>UniRef50_Q8Y6C3 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=153; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Listeria monocytogenes
Length = 349
Score = 89.0 bits (211), Expect = 9e-17
Identities = 47/113 (41%), Positives = 66/113 (58%), Gaps = 1/113 (0%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ G+A+GC Q ETAEMP MY YD+AGF +G VE+ ++
Sbjct: 120 IVKGVADGCEQAGAALIGGETAEMPDMYGADDYDLAGFTVGAVEKQKLITE-GAVQAGDT 178
Query: 193 XXXLPSNGVHSNGFSLIHKL-MKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+PS+G+HSNG+SL+ K+ K N TL+ A S+ + L EEL+KPTRIY
Sbjct: 179 LIGIPSSGIHSNGYSLVRKIFFKDNEFTLD--AEISELDVPLVEELLKPTRIY 229
Score = 39.9 bits (89), Expect = 0.052
Identities = 22/63 (34%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSV 575
W + P+F + G + + EM FN GIGMV+ V+ D + + G A VIG V
Sbjct: 274 WPMLPIFDVVKKYGQLNEMEMYEIFNMGIGMVLAVAKSDVEKTLEVLVQNGEAAYVIGEV 333
Query: 576 QAR 584
R
Sbjct: 334 TTR 336
>UniRef50_O68186 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=6; Firmicutes|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Lactococcus lactis subsp. cremoris (strain MG1363)
Length = 340
Score = 88.6 bits (210), Expect = 1e-16
Identities = 46/112 (41%), Positives = 64/112 (57%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
V+AG+AEGC Q ETAEMPGMY+ YD+AGFA+GV E+S ++
Sbjct: 122 VVAGVAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGDV 181
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+HSNG+SL+ K+ LN+ P + L + L+ PT+IY
Sbjct: 182 LLGLASSGIHSNGYSLVRKVFA--DFDLNESLPELDQSLI--DTLLTPTKIY 229
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/56 (35%), Positives = 34/56 (60%), Gaps = 2/56 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSY--GAMV 563
W + P+F + G+++ +EM FN GIGMV+ V+PE+ A + + ++ G MV
Sbjct: 274 WDVLPIFKALEKYGSIKHEEMYEIFNMGIGMVIAVAPENAAALKKELNAFEIGQMV 329
>UniRef50_Q3AUU9 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=17; Cyanobacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Synechococcus sp. (strain CC9902)
Length = 345
Score = 87.0 bits (206), Expect = 3e-16
Identities = 44/112 (39%), Positives = 64/112 (57%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
V+ GIA+GCRQ ETAEMPG Y G YD+AGF + VVE ++
Sbjct: 116 VVEGIADGCRQSGCALLGGETAEMPGFYPQGRYDLAGFCVAVVEEDDLID-GRSISPGDQ 174
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+GVHSNGFSL+ K+++K G +N+ + + + L +L+ PT +Y
Sbjct: 175 IIGIASSGVHSNGFSLVRKVLEKAG--INENSQYGPDNRRLLNDLLAPTTLY 224
Score = 50.8 bits (116), Expect = 3e-05
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMN--SMRSYGAM 560
+ A W P+F W+ AGA+ + ++ TFN GIG ++V E + ++ + ++ A
Sbjct: 265 IEAEAWPRSPLFQWLQSAGAIPERDLWHTFNMGIGFCLVVPKEAEQTALDVCHLNNHQAW 324
Query: 561 VIGSVQARPP 590
VIG V PP
Sbjct: 325 VIGEVLKTPP 334
>UniRef50_Q2JL07 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=2; Synechococcus|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 354
Score = 85.0 bits (201), Expect = 1e-15
Identities = 44/112 (39%), Positives = 62/112 (55%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
V+ GI GC++ ETAEMPG Y PG YD+AGF +G+VE++ IL
Sbjct: 121 VIDGILAGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCIGIVEKTAILD-GSRVQLGDR 179
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+G+HSNG+SL+ +++ G + + P L E + PTRIY
Sbjct: 180 LLALPSSGLHSNGYSLVRRIVADRGWRWDHRPPGWDR--PLAEVFLTPTRIY 229
Score = 52.4 bits (120), Expect = 9e-06
Identities = 28/74 (37%), Positives = 39/74 (52%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVI 566
L H W + F W+ + G VE EM RTFN G+G V+++ PE + V + + A I
Sbjct: 270 LQPHSWPIPQEFLWLQEQGQVETLEMFRTFNLGVGYVLVIPPEAENQVRSLLPE--AFPI 327
Query: 567 GSVQARPPHGAPVL 608
G V A P + VL
Sbjct: 328 GEVVAACPGESRVL 341
>UniRef50_Q01RS7 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=3; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Solibacter usitatus (strain Ellin6076)
Length = 357
Score = 84.2 bits (199), Expect = 2e-15
Identities = 47/116 (40%), Positives = 61/116 (52%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA +V+ GIA GC++ ETAEMPGMY G YD+AGF +G ERSH+L
Sbjct: 127 VAAAVVGGIARGCKRNGCALIGGETAEMPGMYTDGEYDLAGFIVGAAERSHLL-TGKTIR 185
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS G+H+NG+SL KL + K G T+G+ L+ R Y
Sbjct: 186 PGDVLLALPSTGLHTNGYSLARKLFFEVA-GYGPKTLLPDVGATVGDALLAVHRSY 240
Score = 35.9 bits (79), Expect = 0.84
Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSV 575
W + P+F + G + +D+ RT N G+GM++ V ++R G IGSV
Sbjct: 285 WKIPPLFEALRRIGDIPEDDYRRTLNLGVGMILAVPARGALKAQAALRKIGETPFRIGSV 344
>UniRef50_Q1V2C1 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=2; Candidatus Pelagibacter ubique|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Candidatus Pelagibacter ubique HTCC1002
Length = 342
Score = 83.0 bits (196), Expect = 6e-15
Identities = 46/112 (41%), Positives = 64/112 (57%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
+L GI GC+ ETAEMPG YE G +DIAGFA+G+V+ IL +
Sbjct: 121 ILKGIVRGCKISNCELVGGETAEMPGTYEKGKFDIAGFAVGLVDEKKILSK-KNIKKNDL 179
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+PS+GVHSNG+SL+ ++ K + L K F L +EL++PT+IY
Sbjct: 180 VLAIPSSGVHSNGYSLVRHVLNKKKINLK-KNSF------LKKELLRPTKIY 224
Score = 44.8 bits (101), Expect = 0.002
Identities = 19/56 (33%), Positives = 34/56 (60%), Gaps = 1/56 (1%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSM-RSYGAMVIGSVQA 581
+F W+ ++D+EML+TFNCG+G +IV+P++ + + + VIG + A
Sbjct: 274 IFKWLKQNN-IDDEEMLKTFNCGVGFCLIVNPKNLNKITKFFTKEFKPYVIGKITA 328
>UniRef50_Q88U27 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=2; Lactobacillaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Lactobacillus plantarum
Length = 341
Score = 82.6 bits (195), Expect = 7e-15
Identities = 46/115 (40%), Positives = 63/115 (54%), Gaps = 1/115 (0%)
Frame = +1
Query: 7 RSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXX 186
+++L G+ GC+Q ETAEMP MY YD+AGFA+G+ R+ +L
Sbjct: 111 KAILTGVVAGCQQAHTALIGGETAEMPDMYGQDHYDLAGFAVGIANRADLL-SPANVRAG 169
Query: 187 XXXXXLPSNGVHSNGFSLIHK-LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPSNG+HSNGFSL+ L K++ L F + G L EL++PT IY
Sbjct: 170 DVLIGLPSNGLHSNGFSLVRDILFKQHDYQLT--TVFDELGHDLQTELLRPTTIY 222
Score = 38.3 bits (85), Expect = 0.16
Identities = 18/61 (29%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV--IGSV 575
W + P+ +++ G + ++ TFN G+GMV+IV P+ A V ++ + +G+V
Sbjct: 267 WPVPPIMTLLAELGGLTATDLRSTFNLGLGMVLIVHPDQVAAVTANLTANAQSYYRVGTV 326
Query: 576 Q 578
Q
Sbjct: 327 Q 327
>UniRef50_Q20143 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 974
Score = 82.6 bits (195), Expect = 7e-15
Identities = 44/117 (37%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSH-ILPRXXXX 177
+A VL I+E C + ETAEMPG+Y +D+AG A+ E + +LP
Sbjct: 535 MATQVLTSISEACVEAECSLIGGETAEMPGVYSTHQWDLAGCAIAARESTWPMLPLSSEI 594
Query: 178 XXXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+G+HSNGFSL K++ NG+ ND P+ + T G EL++ T++Y
Sbjct: 595 RDGDVILGLPSSGLHSNGFSLARKILTVNGVKYNDPLPWDSKS-TFGTELLRGTKLY 650
Score = 60.1 bits (139), Expect = 5e-08
Identities = 24/50 (48%), Positives = 34/50 (68%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSY 551
W +F W++ AG V+ EM+RTFNCGIGMV+IVSP++ V +R +
Sbjct: 697 WKFREIFNWMAAAGPVDTKEMIRTFNCGIGMVLIVSPDNVEKVKKQLRKH 746
>UniRef50_A5UWC7 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=5; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Roseiflexus sp. RS-1
Length = 341
Score = 82.2 bits (194), Expect = 1e-14
Identities = 39/115 (33%), Positives = 65/115 (56%)
Frame = +1
Query: 4 ARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXX 183
A +++A +A CR+ ETA+MP +Y G +++AG +GVV R+ +LPR
Sbjct: 118 AATLVASVAAACREVGCVLLGGETAQMPDVYREGAFELAGTIVGVVRRAQMLPR--NVAA 175
Query: 184 XXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+G+H+NG+SL +++ + D P G ++GE L++P R+Y
Sbjct: 176 GDVILALPSSGLHTNGYSLARRVLGRGSAWGYDARPAELNGRSIGEALLEPHRVY 230
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/42 (40%), Positives = 25/42 (59%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQAD 527
W + P+ + A +++ E RT N G+GM+VIV P D AD
Sbjct: 276 WTIPPICTLVVQAAGLDEREAFRTLNMGLGMLVIV-PSDAAD 316
>UniRef50_Q18CW2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=6; Clostridiales|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Clostridium difficile (strain 630)
Length = 358
Score = 81.4 bits (192), Expect = 2e-14
Identities = 45/114 (39%), Positives = 66/114 (57%), Gaps = 2/114 (1%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ GIA+GC+ ETAEMPGMY YD+AGF++G+ ++ I+
Sbjct: 119 IVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGIADKEKIV-SGNNVKSGDV 177
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDK-APFSQE-GLTLGEELIKPTRIY 348
+ S+GVHSNGFS I K+ + T N K + +E G+T+GE L+ PT+IY
Sbjct: 178 LVGISSSGVHSNGFSFIRKIFLE---TYNYKMEQYVEELGMTVGEALLTPTKIY 228
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/50 (40%), Positives = 31/50 (62%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMN 536
+N W P+F I AV++ E+ ++FN GIG+V+IV E+ DV+N
Sbjct: 268 INKKSWEKPPIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVN 317
>UniRef50_UPI00015BCC94 Cluster: UPI00015BCC94 related cluster; n=1;
unknown|Rep: UPI00015BCC94 UniRef100 entry - unknown
Length = 336
Score = 81.0 bits (191), Expect = 2e-14
Identities = 41/112 (36%), Positives = 61/112 (54%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ GI GC + ETAEMP Y+ G YD+AGF +G+ ++ I+
Sbjct: 116 LIEGIITGCEEANTPLVGGETAEMPSFYKDGEYDLAGFCIGICKKDEIV-TGQDVKENDI 174
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+PS+G HSNGFSL+ +++K+ + ND + G L E L+ PTRIY
Sbjct: 175 IIAIPSSGFHSNGFSLVRYILEKHNIKYNDY--IKEFGKELWEILLTPTRIY 224
Score = 44.4 bits (100), Expect = 0.002
Identities = 18/66 (27%), Positives = 38/66 (57%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSVQARPPHG 596
+F W G ++ +EM +TFN G+G ++I+ +D+ +N+++ + V+G ++ +
Sbjct: 272 LFLWFQKLGNIKKEEMYKTFNMGVGFMIIIEEKDKEVALNTIKD--SFVVGYIEQSKDNS 329
Query: 597 APVLVD 614
VL D
Sbjct: 330 KIVLND 335
>UniRef50_Q3AMJ2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=16; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Synechococcus sp. (strain CC9605)
Length = 345
Score = 81.0 bits (191), Expect = 2e-14
Identities = 46/112 (41%), Positives = 62/112 (55%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
V+ GIA+GCRQ ETAEMPG Y G YDIAGF + VVE ++
Sbjct: 116 VVEGIADGCRQSGCALLGGETAEMPGFYPQGRYDIAGFCVAVVEEDELID-GQRIQPGDS 174
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+GVHSNGFSL+ K+++K N +Q L +G +L+ PT +Y
Sbjct: 175 VIGVASSGVHSNGFSLVRKVLEKANADANTVYGDNQRPL-IG-DLLAPTTLY 224
Score = 46.4 bits (105), Expect = 6e-04
Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMR--SYGAM 560
++A W +F W+ +AG + + ++ TFN GIG ++V + V+ R ++ A
Sbjct: 265 IDASSWTRPTLFRWLQEAGNIPERDLWHTFNLGIGFCLVVPARSEDAVIEHCRGKNHQAW 324
Query: 561 VIGSVQARPPHGAPVL 608
+IG+V + P A VL
Sbjct: 325 LIGNVTSNTPGNAAVL 340
>UniRef50_Q8XW52 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=73; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Ralstonia solanacearum (Pseudomonas solanacearum)
Length = 353
Score = 81.0 bits (191), Expect = 2e-14
Identities = 47/115 (40%), Positives = 64/115 (55%)
Frame = +1
Query: 4 ARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXX 183
A +V+ GIA+GC ETAEMP MY G YD+AGFA+G VE+ I+
Sbjct: 127 AATVIKGIAQGCELAGCALIGGETAEMPSMYPAGEYDLAGFAVGAVEKRKIID-GTTIAC 185
Query: 184 XXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G HSNG+SL+ K+++ + LN A F G L + ++ PTRIY
Sbjct: 186 GDVVLGLASSGAHSNGYSLVRKIIEVSRPDLN--ADF--HGQRLQDAIMAPTRIY 236
Score = 68.9 bits (161), Expect = 1e-10
Identities = 34/72 (47%), Positives = 43/72 (59%), Gaps = 2/72 (2%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV--IGSV 575
W L P+F W+ AG V DDEM R FNCGIGM+VIVS D + ++ G V IG +
Sbjct: 281 WTLPPLFQWLQKAGNVADDEMHRVFNCGIGMIVIVSAADAPAAIAHLKDAGETVYQIGEI 340
Query: 576 QARPPHGAPVLV 611
+AR P A +V
Sbjct: 341 RARQPGEAQTIV 352
>UniRef50_A0NKK8 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=2; Oenococcus oeni|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Oenococcus oeni ATCC BAA-1163
Length = 404
Score = 79.0 bits (186), Expect = 9e-14
Identities = 46/112 (41%), Positives = 62/112 (55%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
+++GIA+ CRQ ETAE+P MY YD+A FA+GVVE IL
Sbjct: 173 IVSGIAKACRQSKMALIGGETAELPDMYFKDEYDLAAFAVGVVEEDKIL-NGNRLQFGDT 231
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ SNG+HSNG+SL+ +N L K +SQ +L EL++PTRIY
Sbjct: 232 LLGIASNGLHSNGYSLV-----RNLLLTRAKKTWSQLDDSLQNELLRPTRIY 278
Score = 53.2 bits (122), Expect = 5e-06
Identities = 25/63 (39%), Positives = 38/63 (60%), Gaps = 2/63 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV--IGSV 575
W + +F + + G + + EML TFN GIGMV VS ++ A++MN ++ G V IG V
Sbjct: 323 WPILEIFQRLQETGKLSNHEMLETFNLGIGMVAAVSADESAEIMNQLKKSGEKVYQIGKV 382
Query: 576 QAR 584
+R
Sbjct: 383 VSR 385
>UniRef50_Q1VGN1 Cluster: Phosphoribosylaminoimidazole synthetase;
n=1; Psychroflexus torquis ATCC 700755|Rep:
Phosphoribosylaminoimidazole synthetase - Psychroflexus
torquis ATCC 700755
Length = 208
Score = 77.4 bits (182), Expect = 3e-13
Identities = 38/88 (43%), Positives = 54/88 (61%)
Frame = +1
Query: 85 PGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXXXLPSNGVHSNGFSLIHKLMKKN 264
PG+Y G YDIAGF +G ER +L + LPS+G+H+NGFSL+ K++
Sbjct: 1 PGVYPTGGYDIAGFCVGAAERGQLLSKNKVKKGDVVLA-LPSSGIHANGFSLVRKVVSSL 59
Query: 265 GLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L+L++ APF+ + LG L+ PTRIY
Sbjct: 60 KLSLSEAAPFASH-MPLGTALLAPTRIY 86
Score = 52.0 bits (119), Expect = 1e-05
Identities = 24/61 (39%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Frame = +3
Query: 408 LHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSVQA 581
L PVF W+ A +E E+ RTFNCGIGM++ V PE+ ++ + G + GS+
Sbjct: 133 LPPVFRWLKQAAQMESIELARTFNCGIGMLISVRPENSDNLFKQILQTGEDCWIAGSIVE 192
Query: 582 R 584
R
Sbjct: 193 R 193
>UniRef50_Q1IM88 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=5; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Acidobacteria bacterium (strain Ellin345)
Length = 350
Score = 75.8 bits (178), Expect = 8e-13
Identities = 35/85 (41%), Positives = 49/85 (57%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A ++ G+A+ C+ ETAEMPG Y G YD+AGF +GVVER ++
Sbjct: 123 IAERIVTGLADACKHNGCALIGGETAEMPGFYPDGEYDLAGFIVGVVERDKVI-TGKEVV 181
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLM 255
LPSNG+H+NG+SL KL+
Sbjct: 182 PGDVLVGLPSNGLHTNGYSLARKLL 206
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/35 (48%), Positives = 24/35 (68%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIV 506
W + P+F + G + DEMLRTFN GIGMV+++
Sbjct: 281 WPVLPIFTHMQQLGNISQDEMLRTFNMGIGMVLVI 315
>UniRef50_Q8KG74 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=7; Bacteroidetes/Chlorobi group|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Chlorobium tepidum
Length = 329
Score = 73.7 bits (173), Expect = 3e-12
Identities = 41/116 (35%), Positives = 66/116 (56%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A SV+ G+ + CR+ ETAEMPG+Y+ +D+AG +G+V++ HI+
Sbjct: 113 IAASVVTGMVKACRENGAALIGGETAEMPGVYDVEDFDLAGTIVGMVDQPHII-NGSKIE 171
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS G+H+NG+SL K+ + +N+ F++ T+GEEL+K R Y
Sbjct: 172 AGDVMIGLPSTGLHTNGYSLARKVFEGR---MNE--TFAELDGTVGEELLKVHRSY 222
Score = 40.7 bits (91), Expect = 0.030
Identities = 22/67 (32%), Positives = 38/67 (56%), Gaps = 4/67 (5%)
Frame = +3
Query: 387 LNAHW--WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRS--YG 554
L+ W W +F I G+V +++M RTFN G+G+V+IV+ + +M ++S
Sbjct: 260 LSVDWNSWPEPLIFDLIRKEGSVPEEDMRRTFNLGLGLVMIVAKDRVDHIMGYLKSKDEN 319
Query: 555 AMVIGSV 575
A ++G V
Sbjct: 320 AYIVGEV 326
>UniRef50_A0NAS3 Cluster: ENSANGP00000030290; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000030290 - Anopheles gambiae
str. PEST
Length = 332
Score = 73.3 bits (172), Expect = 5e-12
Identities = 40/93 (43%), Positives = 53/93 (56%)
Frame = +1
Query: 70 ETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXXXLPSNGVHSNGFSLIHK 249
ETAEMPGMY PG YD+AGF +G+VE+ ++ LPS+G HSNGFSL+ K
Sbjct: 7 ETAEMPGMYNPGDYDVAGFCVGIVEKDQVID-GSKIKAGDKIIALPSSGFHSNGFSLVRK 65
Query: 250 LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ N+ EG + E L+ PTR+Y
Sbjct: 66 VFP----DFNE----DFEGKPIHETLLVPTRLY 90
>UniRef50_A7C0T2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Beggiatoa sp. PS|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Beggiatoa sp. PS
Length = 283
Score = 72.5 bits (170), Expect = 8e-12
Identities = 46/137 (33%), Positives = 70/137 (51%), Gaps = 21/137 (15%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V V+ GIA+GC ETAEMPG+Y+ +D+AGF +G+VE++ I+
Sbjct: 29 VGAQVIEGIAKGCELAGAALIGGETAEMPGIYQQADFDLAGFCVGIVEKNAIID-GSLVS 87
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKK--------NGLTLNDKAPFSQ------------ 300
+ S+G HSNG+SLI K++++ N T + P+
Sbjct: 88 AGDALIGIASSGPHSNGYSLIRKILERSENSSLAPNATTSPNSPPYQGGEGGGKEGNQSD 147
Query: 301 -EGLTLGEELIKPTRIY 348
+G +LGE L++PTRIY
Sbjct: 148 FDGRSLGEVLLEPTRIY 164
Score = 54.4 bits (125), Expect = 2e-06
Identities = 22/44 (50%), Positives = 28/44 (63%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPED 518
+N W +F W+ G + D EM RTFNCGIGMVV V+PE+
Sbjct: 204 INVQSWTRPAIFDWLQQQGNISDREMYRTFNCGIGMVVCVAPEN 247
>UniRef50_A4EBR4 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Collinsella aerofaciens ATCC
25986|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase - Collinsella aerofaciens ATCC 25986
Length = 367
Score = 72.1 bits (169), Expect = 1e-11
Identities = 43/123 (34%), Positives = 65/123 (52%), Gaps = 11/123 (8%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ G+A+GC+ E AE PG+ P YD+AGF +GVV+R +L
Sbjct: 124 IIKGVADGCKLAGCALVGGEMAEHPGVMAPADYDLAGFTVGVVDRPKMLD-PANVRPGDV 182
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLT--LNDKAPFSQE---------GLTLGEELIKPT 339
LPS GVHSNG+SL+ K++ +G+ + A ++E G +L + L+ PT
Sbjct: 183 ILGLPSTGVHSNGYSLVRKVIGVDGIKPGTPEAAAKAEELSRPLEELGGASLADALLTPT 242
Query: 340 RIY 348
RIY
Sbjct: 243 RIY 245
Score = 45.6 bits (103), Expect = 0.001
Identities = 18/51 (35%), Positives = 32/51 (62%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG 554
W + PV ++S + +E +TFN G+G+ +IV+PED+A V ++ + G
Sbjct: 295 WDVPPVITYVSRQAELAPNEACKTFNMGVGLCLIVAPEDEAAVTEALVALG 345
>UniRef50_A5FPS3 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=3; Dehalococcoides|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Dehalococcoides sp. BAV1
Length = 354
Score = 71.3 bits (167), Expect = 2e-11
Identities = 39/112 (34%), Positives = 62/112 (55%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ G++ C + ETAEMPG+Y YD+AGF +GVVE+ ++L
Sbjct: 136 IVKGLSTACLEAGCALIGGETAEMPGLYHGEDYDLAGFIVGVVEKENMLIN-RGIKPGDI 194
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L SNG+H+NG+SL K++ ++ +L+ P + G T GE ++ P R Y
Sbjct: 195 ILGLASNGLHTNGYSLARKVLGESRESLDKYYP--ELGQTAGEAMLVPHRSY 244
Score = 52.0 bits (119), Expect = 1e-05
Identities = 25/71 (35%), Positives = 40/71 (56%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSVQA 581
W + P+F I G ++ +EM FN GIGMV+I E+ +M ++ A +IG + A
Sbjct: 287 WEIPPLFQLIQKTGGIDHEEMFHVFNMGIGMVIIAGTEEAGLIMKNLPE--AKIIGEIIA 344
Query: 582 RPPHGAPVLVD 614
R GA V+++
Sbjct: 345 R-QSGAQVIIE 354
>UniRef50_Q7UI59 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=4; Planctomycetaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Rhodopirellula baltica
Length = 359
Score = 70.1 bits (164), Expect = 4e-11
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 4/116 (3%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ GI++GC ETA MP MY YD+AGFA+GVVER ++
Sbjct: 125 IVQGISDGCVDGDLALLGGETAIMPDMYGTDDYDLAGFAVGVVERKRLVD-GHLIAPGDV 183
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGL----TLGEELIKPTRIY 348
L ++G+HSNGFSL+ K++ +G +D + TL + ++PT+IY
Sbjct: 184 VLGLQASGLHSNGFSLVRKIIADHGHQWSDVIDELNQDTKTPETLAQVCLRPTKIY 239
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/51 (39%), Positives = 27/51 (52%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG 554
W +P+F W+ G V EM R FN GIGM V+V+ A V + + G
Sbjct: 288 WTPNPIFQWLQQTGDVATSEMRRVFNMGIGMAVVVNEYYAASVASQVAKAG 338
>UniRef50_Q8F242 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=6; Leptospira|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Leptospira interrogans
Length = 344
Score = 70.1 bits (164), Expect = 4e-11
Identities = 41/112 (36%), Positives = 58/112 (51%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
+++GI +GC+ ETAE PG + +D+AGF +G VE+ ++
Sbjct: 122 IVSGIVQGCKMSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSMID-GSTIRSGDK 180
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G HSNGFSLI KL+ K G L Q+ L + +KPTRIY
Sbjct: 181 ILGLESSGPHSNGFSLIRKLLLKEGKYLPTD---PQQVKFLKDYALKPTRIY 229
Score = 33.5 bits (73), Expect = 4.5
Identities = 17/39 (43%), Positives = 23/39 (58%)
Frame = +3
Query: 447 VEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMV 563
+E+ E+ TFN GIG +VIVS E+ M S G +V
Sbjct: 289 IEELELFATFNMGIGYMVIVSEENAELAKKIMESSGEVV 327
>UniRef50_UPI00006A1DFE Cluster: Trifunctional purine biosynthetic
protein adenosine-3 [Includes:
Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS)
(Glycinamide ribonucleotide synthetase)
(Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.;
n=4; Xenopus tropicalis|Rep: Trifunctional purine
biosynthetic protein adenosine-3 [Includes:
Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS)
(Glycinamide ribonucleotide synthetase)
(Phosphoribosylglycinamide synthetase);
Phosphoribosylformylglycinamidine cyclo-ligase (EC 6. -
Xenopus tropicalis
Length = 990
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/116 (28%), Positives = 56/116 (48%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+ +S+ G+ C+ E A +P +Y G Y ++G A+G+VER H LP+
Sbjct: 537 ITQSIATGLVSACKSSGSTLFEREIAYLPNVYPEGSYTLSGCAVGIVEREHKLPQLERMK 596
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L + GVHS+ +LI K+++K + + P + T G+ L+ P Y
Sbjct: 597 AGDWIVGLRAAGVHSDNTALIEKILRKCSIDYSSLLPVGKGEQTWGDMLLNPPLTY 652
Score = 45.2 bits (102), Expect = 0.001
Identities = 21/64 (32%), Positives = 37/64 (57%), Gaps = 1/64 (1%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPE-DQADVMNSMRSYGAMV 563
++A W L +F+W+ GA+ + EM+ +FNCG+G V+I Q V+ + A +
Sbjct: 692 VDALCWRLPAIFSWLYKEGALSEQEMVSSFNCGLGAVLIAQKGFAQQIVLQLQKQEEAWL 751
Query: 564 IGSV 575
IG++
Sbjct: 752 IGAL 755
>UniRef50_Q6MIZ3 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Bdellovibrio bacteriovorus|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Bdellovibrio bacteriovorus
Length = 333
Score = 68.5 bits (160), Expect = 1e-10
Identities = 39/116 (33%), Positives = 62/116 (53%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V+ ++AG+ +GCRQ ETAEMPG+Y+ YD+AGF++G + + +
Sbjct: 114 VSEELIAGMVDGCRQSGMALIGGETAEMPGVYQGNEYDLAGFSVGEMSPADLYDE-KDMN 172
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G HSNG+SL+ KL++ ++ L +EL+ PTRIY
Sbjct: 173 EGDVLIGIASSGFHSNGYSLLRKLVQ-------------EDETDLMQELLTPTRIY 215
Score = 35.5 bits (78), Expect = 1.1
Identities = 22/66 (33%), Positives = 36/66 (54%), Gaps = 3/66 (4%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNS-MRSYGA--MVIGSVQAR 584
PVF I + +E+ RTFN G+G+V+++ + QAD + + + S G +GS+Q
Sbjct: 266 PVFGKIIPRAGLSGEELYRTFNMGVGLVLLIK-KGQADAVQTWLASQGEKHWRLGSIQKG 324
Query: 585 PPHGAP 602
AP
Sbjct: 325 SGQIAP 330
>UniRef50_A6PTZ2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Victivallis vadensis ATCC
BAA-548|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase - Victivallis vadensis ATCC BAA-548
Length = 347
Score = 67.7 bits (158), Expect = 2e-10
Identities = 40/112 (35%), Positives = 57/112 (50%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
VL GIA+ C+ ETAEMPGMY +D+ G G+VE+S ++
Sbjct: 124 VLTGIADACKAANVAVLGGETAEMPGMY-GNDFDLVGVITGIVEKSKMI-TGEKIRPGHV 181
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
SNG+H+NGFSL K++ + N + + G T+GE L+KP Y
Sbjct: 182 AIGFGSNGLHTNGFSLARKILFSQ-CSYNVRTYLDELGETVGEALLKPHTSY 232
Score = 32.7 bits (71), Expect = 7.8
Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMV--VIVSPEDQADVMNSMRSYGAMVIGSV 575
P+F + + G V+ E R FN G+GMV V + D+A + + + +IG +
Sbjct: 282 PIFKVLVEKGHVDPIEAYRVFNMGVGMVWFVPANAADEAVEIGRSKGFTTGIIGEI 337
>UniRef50_Q73N89 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=2; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Treponema denticola
Length = 366
Score = 67.3 bits (157), Expect = 3e-10
Identities = 41/112 (36%), Positives = 58/112 (51%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ G+A+ C++ ETAEMPG+Y G +DIAG +G V+ ILP+
Sbjct: 142 IVGGMAKACKESGCALIGGETAEMPGVYMEGEFDIAGTIVGAVDEEKILPK-KNIKEGDL 200
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+ H+NG+SLI K G+ LN P + L E L+KP R Y
Sbjct: 201 LIGLASDSPHTNGYSLIRTAFK--GVDLNTVYP--ELKAPLHEVLLKPHRSY 248
Score = 43.2 bits (97), Expect = 0.006
Identities = 20/59 (33%), Positives = 31/59 (52%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSVQ 578
W + P++ I DEM R FN GIGM+ +VSP D A+ + + +IG ++
Sbjct: 295 WPVPPLYPLIQKLTGASGDEMYRVFNMGIGMIAVVSP-DMAEKYRELVGEESWIIGKLE 352
>UniRef50_Q8PX06 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=10; Euryarchaeota|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Methanosarcina mazei (Methanosarcina frisia)
Length = 333
Score = 66.5 bits (155), Expect = 5e-10
Identities = 34/115 (29%), Positives = 63/115 (54%)
Frame = +1
Query: 4 ARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXX 183
A + G+ +G ETA +P + + +D+AG LG +++ I+
Sbjct: 116 AEQIGEGLLKGAEISRMSIVGGETATLPDIIKG--FDLAGTCLGYLKKEDII-EGGRVRV 172
Query: 184 XXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+PS GVHSNG++L+ K+++++G + +D P+ T+G++L++PTRIY
Sbjct: 173 GDVIVGIPSTGVHSNGYTLVRKIIQESGYSYHDPCPY-DSSKTIGDDLLEPTRIY 226
Score = 37.5 bits (83), Expect = 0.28
Identities = 18/53 (33%), Positives = 31/53 (58%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSV 575
+F ++ G V+D EM RTFN G+G ++I+ PE A+ + G ++G +
Sbjct: 271 IFKFLRKEGGVDDLEMYRTFNMGMGFLIIL-PEKDAE--KAAEITGGKIVGKI 320
>UniRef50_Q83FJ9 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Length = 337
Score = 64.9 bits (151), Expect = 2e-09
Identities = 38/112 (33%), Positives = 60/112 (53%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ G+A C++ ETAE P + YD+AG A GVVE S +L +
Sbjct: 120 IVGGVARACQEIDCVLLGGETAEHPEVMARNQYDLAGAATGVVEASDLLGK-DKVKTGDV 178
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G+H+NGFSL+ K+ + ++ + P Q T GE L++PTR+Y
Sbjct: 179 LIGVASSGLHANGFSLVRKICR--DVSFAEYCPDLQ--TTWGEALLEPTRMY 226
>UniRef50_Q03Y87 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Leuconostoc mesenteroides subsp.
mesenteroides ATCC 8293|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 345
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/116 (31%), Positives = 59/116 (50%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V ++ GIA+ + E+AE+PG+Y YD+A FA+G+ ER +L
Sbjct: 116 VVAEIVTGIAKAAKASNMSLIGGESAELPGLYAEKHYDLAAFAVGIAERQQLL-SAKNVS 174
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+G+HSNG+SL+ ++ G+ +D F+Q L+ PT +Y
Sbjct: 175 EGDVLIGLPSSGIHSNGYSLVRQVF---GVQSDD--DFNQLSPETKATLLTPTALY 225
Score = 44.8 bits (101), Expect = 0.002
Identities = 21/60 (35%), Positives = 36/60 (60%), Gaps = 2/60 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSM--RSYGAMVIGSV 575
W + P+F + G + ++ML TFN G+GM++IV P+ AD M + ++ A V+G +
Sbjct: 270 WPILPIFHELQAKGHLSLEDMLLTFNNGLGMILIVKPQQLADAMTLLTHQNQTAYVLGKI 329
>UniRef50_A4GJ93 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; uncultured marine bacterium
EB0_49D07|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase - uncultured marine bacterium EB0_49D07
Length = 339
Score = 62.9 bits (146), Expect = 6e-09
Identities = 40/112 (35%), Positives = 60/112 (53%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ IA+ C+ ETAEMPG Y YD+AGF++GVVE++ ++
Sbjct: 124 IVKSIAKACKLSNCALLGGETAEMPGHYVGNNYDLAGFSVGVVEKAKLID-GKKIKAGQA 182
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G HSNG+SLI ++KK K P SQ ++ L+KPT +Y
Sbjct: 183 LLAIESSGPHSNGYSLIRSIVKK-------KKP-SQ---SIVNALLKPTHLY 223
Score = 52.8 bits (121), Expect = 7e-06
Identities = 21/61 (34%), Positives = 37/61 (60%), Gaps = 2/61 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPED--QADVMNSMRSYGAMVIGSV 575
W +F W+ D+G + +MLR FNCG+GMV ++ +D +A + ++ + V+GSV
Sbjct: 268 WKFPKIFQWLQDSGKISQMDMLRIFNCGVGMVCVLDTKDVEKAQKILKKNNFNSFVMGSV 327
Query: 576 Q 578
+
Sbjct: 328 K 328
>UniRef50_A4M895 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Petrotoga mobilis SJ95
Length = 322
Score = 61.7 bits (143), Expect = 1e-08
Identities = 36/93 (38%), Positives = 52/93 (55%)
Frame = +1
Query: 70 ETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXXXLPSNGVHSNGFSLIHK 249
ETAE+PG+++ DIAGFA+G+VE+ +I L S+G+HSNG+SL+ K
Sbjct: 130 ETAELPGVFKNKSEDIAGFAVGIVEKDNIFD-YSKVEPGDKLIGLSSSGIHSNGYSLVRK 188
Query: 250 LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L+ + +T EEL+ PTRIY
Sbjct: 189 LL-------------DERKITFTEELLNPTRIY 208
Score = 44.4 bits (100), Expect = 0.002
Identities = 20/49 (40%), Positives = 31/49 (63%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRS 548
W + VF I +G V D+EM +TFN GIGM+ +VS ++ ++V + S
Sbjct: 250 WEIPSVFESIKQSG-VSDEEMFKTFNMGIGMIYVVSEDNLSEVTKILES 297
>UniRef50_Q9RUJ2 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=5; Bacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Deinococcus radiodurans
Length = 354
Score = 61.3 bits (142), Expect = 2e-08
Identities = 41/112 (36%), Positives = 55/112 (49%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
V++G A+ C ETAEMPG+Y G DI G +GVV+R +++
Sbjct: 128 VVSGAAQACEALGVALLGGETAEMPGVYVDGELDIVGTIVGVVDRPNLID-GGRIEVGDA 186
Query: 193 XXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
LPS+G+H+NGFSL M + L N+ A G TL L P R Y
Sbjct: 187 VIALPSSGLHTNGFSLAR--MALDALDWNE-ARSDLGGQTLAAVLPVPHRSY 235
Score = 36.3 bits (80), Expect = 0.64
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 2/62 (3%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAM--VIGSV 575
W + P+F I VE E R N G+G + IV + M ++R+ G VIG +
Sbjct: 281 WAVPPLFELIVREAGVERQEAFRALNMGVGFLFIVPAAQREQAMQTLRAAGEQPWVIGEM 340
Query: 576 QA 581
A
Sbjct: 341 VA 342
>UniRef50_Q57656 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=6; Methanococcales|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Methanococcus jannaschii
Length = 350
Score = 60.1 bits (139), Expect = 5e-08
Identities = 40/117 (34%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A + G+ EG ++ ETA +P M + G+ D+AG L +V++ I+
Sbjct: 110 IAEQIGKGLNEGAKEANINIVGGETATLPDMIK-GI-DLAGTVLAIVKKDEIIT-GKDVK 166
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNG-LTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+HSNG SL K+ L +NDK + G T+ EEL+ PTRIY
Sbjct: 167 AGDVIVGLRSSGIHSNGLSLARKVFFDIAKLDINDKLSY---GKTVAEELLTPTRIY 220
Score = 48.0 bits (109), Expect = 2e-04
Identities = 27/56 (48%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSV 575
P+F I G V D+EM RTFN GIG VIV ED V+ Y A VIG V
Sbjct: 268 PIFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDEEDANKVIKIANKYNIPAQVIGRV 323
>UniRef50_Q5ZUW5 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=15; Gammaproteobacteria|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Legionella pneumophila subsp. pneumophila (strain
Philadelphia 1 /ATCC 33152 / DSM 7513)
Length = 358
Score = 57.6 bits (133), Expect = 2e-07
Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 1/109 (0%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ G+ + C + ETAEMP Y G +D+ G GVVE+ +
Sbjct: 133 IIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEAI-LGKDITPGDS 191
Query: 193 XXXLPSNGVHSNGFSLIHKLM-KKNGLTLNDKAPFSQEGLTLGEELIKP 336
PS+G+H+NG+SL KL+ + G T+ ++ + T+GE L+ P
Sbjct: 192 VLAFPSSGLHTNGYSLARKLLFELGGYTV--ESQLDELDATVGEALLVP 238
Score = 43.6 bits (98), Expect = 0.004
Identities = 17/46 (36%), Positives = 30/46 (65%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSY 551
P+F + G ++D EM RTFN GIG+V+I SP +++ +++ +
Sbjct: 292 PIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIYTALKEF 337
>UniRef50_Q9UY56 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=4; Thermococcaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Pyrococcus abyssi
Length = 334
Score = 57.6 bits (133), Expect = 2e-07
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 1/117 (0%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V + V G+ +G + ETA MP + YD+AG A+G+VE+ ++
Sbjct: 114 VFKQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVIT-GERIR 170
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLM-KKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G+HSNG +L KL+ K GL + EG L E L++PTRIY
Sbjct: 171 PGDSVIGISSSGIHSNGLTLARKLLIPKYGL------DYEYEGRKLWEWLLEPTRIY 221
Score = 37.1 bits (82), Expect = 0.36
Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSM-RSYGAMVIGSV 575
+F I + G V DEM R FN G+G +V+V E++ + + + R Y + +G+V
Sbjct: 266 IFKLIHENG-VPLDEMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNV 318
>UniRef50_Q9X0X8 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=4; Thermotogaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Thermotoga maritima
Length = 311
Score = 56.4 bits (130), Expect = 6e-07
Identities = 40/116 (34%), Positives = 59/116 (50%)
Frame = +1
Query: 70 ETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXXXLPSNGVHSNGFSLIHK 249
ETAEMP +Y G +D GFA+GV+E+ +P +PS+G HSNG+SLI +
Sbjct: 130 ETAEMPDVYR-GDWDAVGFAVGVLEKR--IP-VDKIKEGDVIVGIPSSGFHSNGWSLIRR 185
Query: 250 LMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIYXXXXXXXXXXXXXXXXTGGICIR 417
++K+ + + ++ PF EL+K TRIY TGG +R
Sbjct: 186 IIKEESIKI-EELPF---------ELLKGTRIYREVIELFDLVKGIAHVTGGGVVR 231
>UniRef50_A2SPR4 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=3; Methanomicrobiales|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 331
Score = 54.8 bits (126), Expect = 2e-06
Identities = 38/109 (34%), Positives = 54/109 (49%)
Frame = +1
Query: 22 GIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXXX 201
G+ EG R ETA + GM G+ D+AG LGV ++ ++
Sbjct: 121 GLNEGARLSNLNIVGGETATLKGMIN-GL-DLAGTCLGVQDKDKVVT-GEKVAPGDIIIG 177
Query: 202 LPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S GVHSNG++L K+ ++NG A G T+GE L+ PTRIY
Sbjct: 178 VASTGVHSNGYTLARKVAEENG----GYATVLLSGRTVGEALLVPTRIY 222
Score = 42.3 bits (95), Expect = 0.010
Identities = 21/53 (39%), Positives = 34/53 (64%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSV 575
+ AWI++ G +E +E+ RTFN G+G IV P++ + + SM G+ V+G V
Sbjct: 267 ILAWIAEKGNLEMNELYRTFNMGMGFAFIV-PKESVETVLSMVE-GSKVVGRV 317
>UniRef50_A7DS92 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Phosphoribosylformylglycinamidine cyclo-ligase
- Candidatus Nitrosopumilus maritimus SCM1
Length = 340
Score = 54.4 bits (125), Expect = 2e-06
Identities = 35/119 (29%), Positives = 61/119 (51%), Gaps = 3/119 (2%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPG--VYDIAGFALGVVERSHILPRXXX 174
+ + ++ G+ +G ++ ETA MP + E +D+AG +G+VE+ ++
Sbjct: 115 IFKKIVEGLVKGAKKSAMPIVGGETAIMPDVIEGKGFAFDLAGMVVGLVEKKQMV-LGNK 173
Query: 175 XXXXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGL-TLGEELIKPTRIY 348
S G+HSNG+SL K + K ++ DK +G+ T+G+ L+KPT IY
Sbjct: 174 IRAGDVIIGANSTGIHSNGYSLARKALLKK-YSVKDKV----KGVGTIGDALLKPTEIY 227
Score = 36.7 bits (81), Expect = 0.48
Identities = 18/43 (41%), Positives = 29/43 (67%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSM 542
P+ I++ G V+ +EM +TFN G+G V V+P+DQA + S+
Sbjct: 272 PIMGLIAEQG-VKSEEMYKTFNMGVGFCV-VAPKDQATKIKSI 312
>UniRef50_Q9UX29 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=4; Sulfolobaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Sulfolobus solfataricus
Length = 323
Score = 51.2 bits (117), Expect = 2e-05
Identities = 34/116 (29%), Positives = 59/116 (50%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
V ++ GI +G ++ ETA MP + +D++ A+GVV++ L
Sbjct: 110 VVNEIIDGIVQGAKEADVEVIGGETAIMPDVIRG--FDLSCTAIGVVDK---LKTGAEIR 164
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+H+NG+SL+ KL+++ L+L++ EL+KPT+IY
Sbjct: 165 PGDYVLGLESSGIHANGYSLVRKLIEEGKLSLDE----------YKNELLKPTKIY 210
Score = 37.9 bits (84), Expect = 0.21
Identities = 19/48 (39%), Positives = 27/48 (56%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAM 560
+F I AG V +EM + FN GIG+V+ VS E +V + YG +
Sbjct: 253 IFKTIEKAG-VAHEEMYKVFNMGIGIVLFVSEELMKEVKTKLEGYGTV 299
>UniRef50_O27272 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=3; Methanobacteriaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Methanobacterium thermoautotrophicum
Length = 338
Score = 50.8 bits (116), Expect = 3e-05
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
VA + G+A G ETA +PG+ D+A +G V+ I+
Sbjct: 110 VAGEIGKGLAMGAEMARVAIIGGETASLPGIIRN--LDLAATGIGFVDVDRIIT-GEDVS 166
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKL-MKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+HSNG SL ++ + L+ D+ P S ++G+EL++PTRIY
Sbjct: 167 PGDTVIGLESSGIHSNGLSLARRVFFDELELSPEDEMPGSSS--SVGDELLRPTRIY 221
Score = 34.3 bits (75), Expect = 2.6
Identities = 22/56 (39%), Positives = 30/56 (53%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSVQAR 584
+F I +AG V+ EM R FN G+G +V+P+D D S+ A IG V R
Sbjct: 269 IFRVIHEAG-VDIREMYRVFNMGVGFCAVVAPDD-VDEALSILGDRAHPIGEVTDR 322
>UniRef50_Q58MH8 Cluster: Putative uncharacterized protein; n=1;
Cyanophage P-SSM2|Rep: Putative uncharacterized protein
- Cyanophage P-SSM2
Length = 331
Score = 50.0 bits (114), Expect = 5e-05
Identities = 29/83 (34%), Positives = 44/83 (53%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
++ GI +GC ETAE P Y+ + D+AGF G+VE+ I+
Sbjct: 124 IMTGIIKGCEIAGMDLLGGETAEHP-QYQMKI-DLAGFCTGIVEKKKIID-GSVIKPSDR 180
Query: 193 XXXLPSNGVHSNGFSLIHKLMKK 261
L S+GVHSNG+S+I+ L ++
Sbjct: 181 IIGLASSGVHSNGYSIINYLARR 203
Score = 35.1 bits (77), Expect = 1.5
Identities = 24/61 (39%), Positives = 35/61 (57%), Gaps = 5/61 (8%)
Frame = +3
Query: 387 LNAH--W--WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADV-MNSMRSY 551
L AH W W + +F I G +++ EM R FN GIG VIV P ++A++ M+ +R
Sbjct: 258 LKAHVDWNAWSVPEIFLEIQRQGNMDELEMRRVFNLGIGYCVIV-PANRAELTMDIIRGE 316
Query: 552 G 554
G
Sbjct: 317 G 317
>UniRef50_A0RWR1 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Cenarchaeum symbiosum|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Cenarchaeum symbiosum
Length = 334
Score = 50.0 bits (114), Expect = 5e-05
Identities = 37/118 (31%), Positives = 55/118 (46%), Gaps = 2/118 (1%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPG--VYDIAGFALGVVERSHILPRXXX 174
+ + G+A G + ETA MPG++ +D+AG +G+V R ++
Sbjct: 111 ILSDIARGLARGAVKASVPIVGGETAIMPGLFSGRGFAFDLAGTVVGLVPRKKMI-LGSS 169
Query: 175 XXXXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
S G+HSNG+SL K + + L LN K G TLG+ L+ PT IY
Sbjct: 170 IKQGDAIIGAHSTGLHSNGYSLARKALGR--LPLNTK---MNRG-TLGDALLAPTEIY 221
>UniRef50_Q97CD7 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=4; Thermoplasmatales|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Thermoplasma volcanium
Length = 338
Score = 49.6 bits (113), Expect = 6e-05
Identities = 33/116 (28%), Positives = 56/116 (48%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+A+ + G G + ETA +P + D++G +G+V+++ I+
Sbjct: 110 IAKQLGNGFNVGAQIANISIVGGETAVVPEIVNH--IDVSGAVIGIVQKNQIIT-GANIK 166
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+HSNGF+ + K++ N + L D F E E L++PTRIY
Sbjct: 167 EGDVIIGLGSSGLHSNGFTTVRKIISDNEINLFDN--FPGESKKTYEVLLEPTRIY 220
>UniRef50_Q8TW12 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Methanopyrus kandleri|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Methanopyrus kandleri
Length = 345
Score = 49.6 bits (113), Expect = 6e-05
Identities = 24/57 (42%), Positives = 37/57 (64%), Gaps = 1/57 (1%)
Frame = +3
Query: 411 HPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSY-GAMVIGSVQ 578
HPVF I + G V +EM RTFN G+GM +IV E+ DV++++ + A ++G V+
Sbjct: 273 HPVFEIIRELGNVPVEEMYRTFNMGMGMALIVPEEEAEDVVDTVSKHVEAKIVGHVE 329
Score = 46.8 bits (106), Expect = 5e-04
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 4/120 (3%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMP----GMYEPGVYDIAGFALGVVERSHILPRX 168
V + G+ +G R+ E A +P G E +D+ LG VE I
Sbjct: 115 VCAEIAEGLGKGAREAGAPIVGGELATLPEVIRGKEEGRGFDLVVACLGRVEGDPITGED 174
Query: 169 XXXXXXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
L S+G+HSNG +L K++ ++D+ P G T+ EEL++PTRIY
Sbjct: 175 VEPGDAIVG--LRSSGIHSNGLTLARKVLLSE-YDVHDELP---HGRTVAEELLEPTRIY 228
>UniRef50_P40178 Cluster: Putative phosphoribosylformylglycinamidine
cyclo-ligase; n=52; Actinobacteria (class)|Rep: Putative
phosphoribosylformylglycinamidine cyclo-ligase -
Streptomyces fradiae
Length = 182
Score = 48.4 bits (110), Expect = 1e-04
Identities = 25/50 (50%), Positives = 35/50 (70%), Gaps = 1/50 (2%)
Frame = +1
Query: 202 LPSNGVHSNGFSLI-HKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
+ S+G+HSNG+SL+ H L G L+ + P + G TLGEEL++PTRIY
Sbjct: 10 MASSGLHSNGYSLVRHVLFDGAGYALDREIP--EFGRTLGEELLEPTRIY 57
Score = 46.4 bits (105), Expect = 6e-04
Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPE--DQADVMNSMRSYGAMVIGSV 575
W PVF + AG+VE E+ +T N G+GM+ +V+PE D A + R A + G +
Sbjct: 102 WTPAPVFGLVGSAGSVERTELEKTLNMGVGMIAVVAPEGADAALATLADRGVDAWICGEI 161
Query: 576 QARPPHG 596
R G
Sbjct: 162 TDRGESG 168
>UniRef50_Q5V4T0 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=5; Halobacteriaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 336
Score = 44.8 bits (101), Expect = 0.002
Identities = 33/110 (30%), Positives = 52/110 (47%)
Frame = +1
Query: 19 AGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXXX 198
AG+ G + ETA MP + + G+ DIAG G+ + + P
Sbjct: 122 AGLRTGAERADVALVGGETAVMPDVIK-GL-DIAGTCAGLAPKDAVFPGEAEAGDAIVGW 179
Query: 199 XLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
PS+G+HSNG +L + + ++ D P + + T+ E L+ PTRIY
Sbjct: 180 --PSSGIHSNGLTLAREAVTQDH-EYTDPFPPNPD-TTIAEALLTPTRIY 225
Score = 44.0 bits (99), Expect = 0.003
Identities = 24/54 (44%), Positives = 30/54 (55%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGAMVIGSV 575
PVF ++ G V D+EM RTFN G G V V D A+++ S A VIG V
Sbjct: 269 PVFEFVQAEGEVSDEEMHRTFNMGTGFVAAVPEADAAEIVAD--SEDARVIGEV 320
>UniRef50_A5D6I8 Cluster: Phosphoribosylaminoimidazole synthetase;
n=1; Perkinsus olseni|Rep: Phosphoribosylaminoimidazole
synthetase - Perkinsus olseni (Perkinsus atlanticus)
Length = 143
Score = 43.2 bits (97), Expect = 0.006
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AM 560
+ A W L VF W + G +E E FN GIGMV+ V+ E + +R A+
Sbjct: 28 IRADTWELPAVFRWXATQGKLEATEXASXFNVGIGMVLGVAAEHKDXXXKVLRGLDEEAV 87
Query: 561 VIGSVQARP 587
VIG + ++P
Sbjct: 88 VIGELVSKP 96
>UniRef50_Q8YRC3 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=3; Nostocaceae|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Anabaena sp. (strain PCC 7120)
Length = 425
Score = 42.3 bits (95), Expect = 0.010
Identities = 27/96 (28%), Positives = 38/96 (39%)
Frame = +1
Query: 16 LAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXXX 195
L G+ EGC++ ET ++ PG DIAG GV+
Sbjct: 187 LDGVVEGCKRIGCVYISGETPQLKTKMIPGRLDIAGSVFGVMPPGVTPIDGTRLAEGNAI 246
Query: 196 XXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQE 303
+ S G+H NGF+ + KL + K P QE
Sbjct: 247 VLVESTGLHENGFTPVRKLAESLPDGYRTKLPSGQE 282
>UniRef50_A7D3C3 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Halorubrum lacusprofundi ATCC
49239|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase - Halorubrum lacusprofundi ATCC 49239
Length = 404
Score = 42.3 bits (95), Expect = 0.010
Identities = 34/115 (29%), Positives = 49/115 (42%)
Frame = +1
Query: 4 ARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXX 183
A V G+A G ETA MP + G+ D+AG G+ + +
Sbjct: 185 AEQVGEGLARGAELADMELVGGETAVMPDVIR-GL-DLAGTCAGLAAKEAVFDGAAEPGD 242
Query: 184 XXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKAPFSQEGLTLGEELIKPTRIY 348
S+G+HSNG +L + + D PF T+GE L++PTRIY
Sbjct: 243 ALVGWR--SSGIHSNGLTLAREAATREH-AYTDPCPFDGYE-TVGEALLEPTRIY 293
Score = 41.5 bits (93), Expect = 0.017
Identities = 17/34 (50%), Positives = 22/34 (64%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPE 515
PVF ++ G+V D+EM RTFN G G V V P+
Sbjct: 337 PVFEFVQSEGSVSDEEMHRTFNMGTGFVAAVDPD 370
>UniRef50_A3H6Y1 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Caldivirga maquilingensis IC-167|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Caldivirga maquilingensis IC-167
Length = 332
Score = 42.3 bits (95), Expect = 0.010
Identities = 22/55 (40%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Frame = +3
Query: 417 VFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYGA--MVIGSV 575
+F I + G VE EM R FN G+G+++IV+ E + V N++ +G V+GSV
Sbjct: 261 IFRVIKETGNVEWSEMYRVFNMGVGLMLIVNEEKASRVENTIDEFGLRHWVMGSV 315
>UniRef50_Q649H9 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=4; environmental samples|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
uncultured archaeon GZfos35A2
Length = 361
Score = 40.3 bits (90), Expect = 0.039
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 109 YDIAGFALGVVERSHILPRXXXXXXXXXXXXLPSNGVHSNGFSLIHKLMKKNGLTLNDKA 288
+D+ G A+G V I+ L S+G+HSNG SL + K G +++
Sbjct: 160 FDLVGTAVGTVSLDKIIV-GANIQEKDVIIGLSSSGIHSNGLSLARHIFLKTG-AIDEH- 216
Query: 289 PFSQEGLTLGEELIKPTRIY 348
F T+G EL++PT IY
Sbjct: 217 -FDVLEKTIGAELLEPTHIY 235
Score = 38.3 bits (85), Expect = 0.16
Identities = 17/38 (44%), Positives = 24/38 (63%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQAD 527
P+F + G V D+EM R +N GIG VI+ PE +A+
Sbjct: 282 PIFTLLQKRGNVTDEEMFRVYNMGIGFCVIL-PEQEAE 318
>UniRef50_Q1VKG8 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Psychroflexus torquis ATCC
700755|Rep: Phosphoribosylformylglycinamidine
cyclo-ligase - Psychroflexus torquis ATCC 700755
Length = 160
Score = 39.9 bits (89), Expect = 0.052
Identities = 19/48 (39%), Positives = 27/48 (56%)
Frame = +3
Query: 387 LNAHWWHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADV 530
+N W L +F I AG + +EM + FN GIG ++V+PE Q V
Sbjct: 94 INYDAWPLPRIFYQIMMAGEIPPEEMKKVFNLGIGYCIVVNPEYQDHV 141
>UniRef50_UPI00015BAB1B Cluster: phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Ignicoccus hospitalis KIN4/I|Rep:
phosphoribosylformylglycinamidine cyclo-ligase -
Ignicoccus hospitalis KIN4/I
Length = 319
Score = 35.9 bits (79), Expect = 0.84
Identities = 26/86 (30%), Positives = 41/86 (47%)
Frame = +1
Query: 1 VARSVLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXX 180
+AR V G+++ ETA MP + + YD++ LGV E PR
Sbjct: 107 LAREVAEGMSKAAEALGAVLAGGETAIMPDVVKG--YDVSCTVLGVREARPQPPRPGDAV 164
Query: 181 XXXXXXXLPSNGVHSNGFSLIHKLMK 258
+ SNG H+NG++LI +L++
Sbjct: 165 IA-----VASNGPHANGYTLIRRLIQ 185
Score = 35.9 bits (79), Expect = 0.84
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Frame = +3
Query: 402 WHLHPVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPED-QADVMNSMRSY--GAMVIGS 572
W + F I +A + +E +TFN G+GM+V+ S E +A ++++ G +V G
Sbjct: 247 WEVPEGFVKIVEAAGMSAEEAYKTFNMGVGMLVVGSEEAVEAFEREGLKAWKAGEVVEGP 306
Query: 573 VQARPPHGAPVL 608
+ P G V+
Sbjct: 307 TEIETPWGKVVI 318
>UniRef50_Q0YFG6 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Geobacter sp. FRC-32|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Geobacter sp. FRC-32
Length = 58
Score = 35.9 bits (79), Expect = 0.84
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 2/45 (4%)
Frame = +3
Query: 447 VEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSV 575
+++ EM RTFNCGIGMV+ V ++ +++ + A VIG +
Sbjct: 1 MKNREMFRTFNCGIGMVLSVPEKEVEEILIRLSGLNETAFVIGEI 45
>UniRef50_A1RQR1 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=1; Pyrobaculum islandicum DSM 4184|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Length = 307
Score = 34.3 bits (75), Expect = 2.6
Identities = 25/82 (30%), Positives = 40/82 (48%)
Frame = +1
Query: 13 VLAGIAEGCRQXXXXXXXXETAEMPGMYEPGVYDIAGFALGVVERSHILPRXXXXXXXXX 192
V+AG+A + ETA +PG+ G+ D+ LG+ + ++ P
Sbjct: 104 VVAGVASKAGEVGAQLLGGETAVLPGVIY-GI-DVVCTVLGI-KAAYTRP----PAPGDV 156
Query: 193 XXXLPSNGVHSNGFSLIHKLMK 258
LPS G H+NG+SL+ +L K
Sbjct: 157 LIGLPSTGPHANGYSLLRRLFK 178
>UniRef50_Q7MXT4 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase, putative; n=32; cellular organisms|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase, putative
- Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 413
Score = 33.9 bits (74), Expect = 3.4
Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Frame = +3
Query: 414 PVFAWISDAGAVEDDEMLRTFNCGIGMVVIVSPEDQADVMNSMRSYG--AMVIGSVQARP 587
P+F I E EM + FN G + V +S E+ + V+ S+G A ++G V+ P
Sbjct: 339 PLFELIQRESLTEWSEMYKVFNMGHRLEVYLSEENASHVIEISESFGIPARIVGRVEEAP 398
>UniRef50_Q8ZZK0 Cluster: Phosphoribosylformylglycinamidine
cyclo-ligase; n=3; Pyrobaculum|Rep:
Phosphoribosylformylglycinamidine cyclo-ligase -
Pyrobaculum aerophilum
Length = 310
Score = 33.1 bits (72), Expect = 5.9
Identities = 23/57 (40%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Frame = +3
Query: 447 VEDDEMLRTFNCGIGMVVIV-SPEDQADVMNSMRSYGAMVIGSVQARPPHGAPVLVD 614
V DE R FN G+GM +I +P D + + Y A +IG V+ P G PV+VD
Sbjct: 254 VPRDEAYRVFNMGVGMALITKTPGDLLKRLEDL-GYSARLIGRVK---PEG-PVVVD 305
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 444,576,210
Number of Sequences: 1657284
Number of extensions: 7701815
Number of successful extensions: 21692
Number of sequences better than 10.0: 76
Number of HSP's better than 10.0 without gapping: 20962
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 21606
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 48760335122
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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