Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I10A02NGRL0001_B18
(639 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P22234 Cluster: Multifunctional protein ADE2 [Includes:... 198 9e-50
UniRef50_UPI0000F33553 Cluster: phosphoribosylaminoimidazole car... 151 1e-35
UniRef50_O28997 Cluster: Phosphoribosylaminoimidazole carboxylas... 115 1e-24
UniRef50_Q73PV9 Cluster: Phosphoribosylaminoimidazole carboxylas... 111 2e-23
UniRef50_Q9VK80 Cluster: CG17024-PA; n=1; Drosophila melanogaste... 83 1e-20
UniRef50_A5G876 Cluster: Phosphoribosylaminoimidazole carboxylas... 73 4e-12
UniRef50_Q83AA3 Cluster: Phosphoribosylaminoimidazole carboxylas... 70 5e-11
UniRef50_Q1MPV1 Cluster: Phosphoribosylcarboxyaminoimidazole (NC... 66 9e-10
UniRef50_Q94IQ2 Cluster: Phosphoribosylaminoimidazole-succinocar... 62 8e-09
UniRef50_Q8A4S9 Cluster: Phosphoribosylaminoimidazole carboxylas... 62 1e-08
UniRef50_O58058 Cluster: Phosphoribosylaminoimidazole carboxylas... 62 1e-08
UniRef50_P41654 Cluster: Probable phosphoribosylaminoimidazole c... 62 1e-08
UniRef50_Q4AJE5 Cluster: 1-(5-Phosphoribosyl)-5-amino-4-imidazol... 62 1e-08
UniRef50_A0LLY4 Cluster: Phosphoribosylaminoimidazole carboxylas... 62 1e-08
UniRef50_Q8PV25 Cluster: Phosphoribosylaminoimidazole carboxylas... 61 3e-08
UniRef50_P96880 Cluster: Phosphoribosylaminoimidazole carboxylas... 60 6e-08
UniRef50_Q7M7S1 Cluster: PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLAS... 59 8e-08
UniRef50_Q2NEA3 Cluster: PurE; n=3; Archaea|Rep: PurE - Methanos... 58 2e-07
UniRef50_Q74AP6 Cluster: Phosphoribosylaminoimidazole carboxylas... 58 2e-07
UniRef50_Q93J44 Cluster: Phosphoribosylaminoimidazole carboxylas... 56 5e-07
UniRef50_Q8XMK7 Cluster: Phosphoribosylaminoimidazole carboxylas... 56 5e-07
UniRef50_A0JU62 Cluster: Phosphoribosylaminoimidazole carboxylas... 56 5e-07
UniRef50_Q5XEE9 Cluster: Phosphoribosylaminoimidazole carboxylas... 55 1e-06
UniRef50_Q11CU3 Cluster: Phosphoribosylaminoimidazole carboxylas... 55 1e-06
UniRef50_A1T5T8 Cluster: Phosphoribosylaminoimidazole carboxylas... 55 1e-06
UniRef50_P21264 Cluster: Phosphoribosylaminoimidazole carboxylas... 55 2e-06
UniRef50_A2SPX9 Cluster: 1-(5-phosphoribosyl)-5-amino-4-imidazol... 54 2e-06
UniRef50_P22348 Cluster: Probable phosphoribosylaminoimidazole c... 54 2e-06
UniRef50_Q55498 Cluster: Phosphoribosylaminoimidazole carboxylas... 50 5e-05
UniRef50_Q2J4S5 Cluster: Phosphoribosylaminoimidazole carboxylas... 50 6e-05
UniRef50_Q6NRP1 Cluster: LOC431975 protein; n=2; Xenopus|Rep: LO... 48 1e-04
UniRef50_P72157 Cluster: Phosphoribosylaminoimidazole carboxylas... 48 2e-04
UniRef50_A4M8A1 Cluster: 1-(5-phosphoribosyl)-5-amino-4-imidazol... 48 3e-04
UniRef50_P15567 Cluster: Phosphoribosylaminoimidazole carboxylas... 48 3e-04
UniRef50_Q98FE6 Cluster: Phosphoribosylaminoimidazole carboxylas... 42 0.009
UniRef50_A7D0F6 Cluster: NCAIR mutase (PurE)-related protein; n=... 38 0.20
UniRef50_A7DMC3 Cluster: Phosphoribosylaminoimidazole carboxylas... 37 0.36
UniRef50_Q6BIQ2 Cluster: Similar to CA4826|IPF1206 Candida albic... 36 0.62
UniRef50_A0RWQ1 Cluster: Phosphoribosylcarboxyaminoimidazole (NC... 36 0.62
UniRef50_Q0RZB9 Cluster: Amino acid decarboxylase; n=9; Actinomy... 35 1.9
UniRef50_A3S2A4 Cluster: ATP-dependent exoDNAse alpha subunit; n... 34 2.5
UniRef50_Q9YBE5 Cluster: PqqE homolog; n=4; Thermoprotei|Rep: Pq... 34 2.5
UniRef50_O28993 Cluster: Putative uncharacterized protein; n=1; ... 34 2.5
UniRef50_A7H038 Cluster: Ncair mutase; n=8; Bacteria|Rep: Ncair ... 34 3.3
UniRef50_Q7VX63 Cluster: Putative hemin storage protein; n=3; Bo... 33 4.4
UniRef50_A4G5F2 Cluster: Universal stress protein; n=4; Herminii... 33 5.8
UniRef50_Q9VIK2 Cluster: CG9317-PA, isoform A; n=7; Endopterygot... 33 5.8
UniRef50_Q6LHZ9 Cluster: Putative uncharacterized protein VPA016... 33 7.7
UniRef50_Q8RJP6 Cluster: Putative uncharacterized protein; n=11;... 33 7.7
UniRef50_A3XH86 Cluster: Peptidase, M20/M25/M40 family protein; ... 33 7.7
>UniRef50_P22234 Cluster: Multifunctional protein ADE2 [Includes:
Phosphoribosylaminoimidazole- succinocarboxamide
synthase (EC 6.3.2.6) (SAICAR synthetase);
Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21)
(AIR carboxylase) (AIRC)]; n=60; Eumetazoa|Rep:
Multifunctional protein ADE2 [Includes:
Phosphoribosylaminoimidazole- succinocarboxamide
synthase (EC 6.3.2.6) (SAICAR synthetase);
Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21)
(AIR carboxylase) (AIRC)] - Homo sapiens (Human)
Length = 425
Score = 198 bits (483), Expect = 9e-50
Identities = 97/184 (52%), Positives = 131/184 (71%), Gaps = 2/184 (1%)
Frame = +3
Query: 6 LDTVKRNFAWVREQLDHL-KPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTS 182
L VK+NF WV E+++ L K +VV+ MGS +D H +KI KA +FG+ +LRVTS
Sbjct: 242 LQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTS 301
Query: 183 AHKATEETLRIMQQYEDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCPP-PSDKLVQD 359
AHK +ETLRI +YE VF+AVAGRSNGLGPV+SGNT+YPVI+CPP D VQD
Sbjct: 302 AHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQD 361
Query: 360 IWSSLSVPSGLGCATVIYPDSAALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLR 539
+WSSL +PSGLGC+TV+ P+ +A AAQI GL ++L+W++LR L +L+ AD+K+R
Sbjct: 362 VWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIR 421
Query: 540 NLSV 551
++
Sbjct: 422 ECNL 425
>UniRef50_UPI0000F33553 Cluster: phosphoribosylaminoimidazole
carboxylase, phosphoribosylaminoimidazole
succinocarboxamide synthetase; n=2; Coelomata|Rep:
phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoimidazole succinocarboxamide
synthetase - Bos Taurus
Length = 402
Score = 151 bits (366), Expect = 1e-35
Identities = 76/130 (58%), Positives = 94/130 (72%), Gaps = 4/130 (3%)
Frame = +3
Query: 171 RVTSAHKATEETLRIMQQYEDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCPP-PSDK 347
RVTSAHK +ETLRI +YE VF+AVAGRSNGLGPVLSGNT+YPVI+CPP D
Sbjct: 273 RVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDW 332
Query: 348 LVQDIWSSLSVPS---GLGCATVIYPDSAALMAAQIIGLQDYLIWARLRVKQLEMATALR 518
QD+WSSL +PS GLGC+T++ P+ +A AAQI GL ++LIWARLR L +L+
Sbjct: 333 GAQDVWSSLRLPSEPIGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLK 392
Query: 519 LADQKLRNLS 548
AD+K+R S
Sbjct: 393 QADKKIREAS 402
>UniRef50_O28997 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=1; Archaeoglobus fulgidus|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Archaeoglobus fulgidus
Length = 180
Score = 115 bits (276), Expect = 1e-24
Identities = 65/155 (41%), Positives = 94/155 (60%), Gaps = 1/155 (0%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
K VI MGS +D ++S+KIA DFG+D +R+ SAHK E+ L I+++YE +VF+
Sbjct: 28 KAVIIMGSKSDLDYSKKIASKLADFGIDAVMRIASAHKTPEKVLEIIKEYEKED--VVFV 85
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL-VQDIWSSLSVPSGLGCATVIYPDSAALM 434
VAGRSN L + NTS PVI PP SDK DI+SS+ +PSG+ V+ ++AAL
Sbjct: 86 TVAGRSNALSGFVDANTSKPVIASPPYSDKFGGADIFSSIRMPSGVAPMLVLEAENAALA 145
Query: 435 AAQIIGLQDYLIWARLRVKQLEMATALRLADQKLR 539
A+I L+D + ++ Q + AD++LR
Sbjct: 146 VAKIFALKDEGVREKVVQFQENKRREIYKADEELR 180
>UniRef50_Q73PV9 Cluster: Phosphoribosylaminoimidazole carboxylase,
PurE protein; n=1; Treponema denticola|Rep:
Phosphoribosylaminoimidazole carboxylase, PurE protein -
Treponema denticola
Length = 159
Score = 111 bits (266), Expect = 2e-23
Identities = 54/128 (42%), Positives = 79/128 (61%), Gaps = 1/128 (0%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V+I MGS +D H++KIA + FG++ +R+ SAHK E + ++++YE ++I
Sbjct: 5 VIILMGSSSDMGHAEKIASELKTFGIEYAIRIGSAHKTAEHVVSMLKEYEALDRPKLYIT 64
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKLV-QDIWSSLSVPSGLGCATVIYPDSAALMA 437
+AGRSN L + G I CPPPSD DI+SSL +PSG+ A V+ P +AAL+A
Sbjct: 65 IAGRSNALSGFVDGFVKGATIACPPPSDSFAGADIYSSLRMPSGISPALVLEPKNAALLA 124
Query: 438 AQIIGLQD 461
A+I L D
Sbjct: 125 ARIFSLYD 132
>UniRef50_Q9VK80 Cluster: CG17024-PA; n=1; Drosophila
melanogaster|Rep: CG17024-PA - Drosophila melanogaster
(Fruit fly)
Length = 395
Score = 83.4 bits (197), Expect(2) = 1e-20
Identities = 45/117 (38%), Positives = 69/117 (58%), Gaps = 1/117 (0%)
Frame = +3
Query: 198 EETLRIMQQYEDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCPP-PSDKLVQDIWSSL 374
EE L+I++ +E LVF+ V R N L V+S NTS+PVINC P SD + ++WS+
Sbjct: 280 EEALQILRTFEAVINNLVFVTVDERLNSLANVISANTSFPVINCTPIQSDTMFMNMWSNS 339
Query: 375 SVPSGLGCATVIYPDSAALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLRNL 545
+ S P++AA A ++ L +++IW++LRV QL A++ D KLR +
Sbjct: 340 NPTSD--------PEAAAKHVASLLSLGNFMIWSKLRVNQLNKQIAIKKIDTKLRGI 388
Score = 39.1 bits (87), Expect(2) = 1e-20
Identities = 17/29 (58%), Positives = 21/29 (72%)
Frame = +3
Query: 3 DLDTVKRNFAWVREQLDHLKPAVHHKVVI 89
DL+TVKRN++WV EQL + P H VVI
Sbjct: 242 DLNTVKRNYSWVIEQLSSIAPPQDHLVVI 270
>UniRef50_A5G876 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=5; Bacteria|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Geobacter uraniumreducens Rf4
Length = 168
Score = 73.3 bits (172), Expect = 4e-12
Identities = 49/159 (30%), Positives = 86/159 (54%), Gaps = 6/159 (3%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V+I MGS +D + AK +F + ++R++SAH++ T + + ED G V I
Sbjct: 5 QVLIVMGSDSDLPVMGEAAKVLTEFDVPFEMRISSAHRSPRRTGLLASEAED-RGVKVVI 63
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIY----PD 419
A AG + L V++ T+ PVI P L V ++S++ +P G+ AT+
Sbjct: 64 AGAGMAAHLAGVVAAETTLPVIGVPIGGGALNGVDALYSTVQMPGGIPVATMAIGRAGAK 123
Query: 420 SAALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKL 536
+AA++A QI+ L D + A+L+ + +MA + D++L
Sbjct: 124 NAAILAVQILALADVSLAAKLKSYRAQMAQEVDEKDKQL 162
>UniRef50_Q83AA3 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=9; Proteobacteria|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Coxiella burnetii
Length = 166
Score = 69.7 bits (163), Expect = 5e-11
Identities = 47/159 (29%), Positives = 78/159 (49%), Gaps = 6/159 (3%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D + + G+ + + SAH+ +ET+ ++ D G VFIA
Sbjct: 6 VAILMGSDSDLSTMETAFTELKSLGIPFEAHILSAHRTPKETVEFVEN-ADNRGCAVFIA 64
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSG--LGCATV--IYPDS 422
AG + L ++ +T PVI P L + + S++ +P G + C + +
Sbjct: 65 AAGLAAHLAGTIAAHTLKPVIGVPMAGGSLGGLDALLSTVQMPGGVPVACTAIGKAGAKN 124
Query: 423 AALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLR 539
AA++AAQII LQD I +L ++ L+ AD+ L+
Sbjct: 125 AAILAAQIIALQDKSIAQKLVQQRTAKRETLKKADENLQ 163
>UniRef50_Q1MPV1 Cluster: Phosphoribosylcarboxyaminoimidazole
(NCAIR) mutase; n=1; Lawsonia intracellularis
PHE/MN1-00|Rep: Phosphoribosylcarboxyaminoimidazole
(NCAIR) mutase - Lawsonia intracellularis (strain
PHE/MN1-00)
Length = 171
Score = 65.7 bits (153), Expect = 9e-10
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Frame = +3
Query: 72 HHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALV 251
H KV IF+GSP+D+ + + V+SAH+ E T ++ E +G V
Sbjct: 3 HVKVAIFIGSPSDESIVSPCTEILTQLNIPYIFTVSSAHRTPERTAELIDSLE-ANGCEV 61
Query: 252 FIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD-- 419
FI AG + L ++ T PVI P S L + + +++ +PSG ATV
Sbjct: 62 FICAAGMAAHLAGAVAARTLKPVIGIPITSSSLGGMDALLATVQMPSGYPVATVALDTAG 121
Query: 420 --SAALMAAQIIGLQDYLIWARL 482
+AA +AAQI+ L D I +L
Sbjct: 122 ARNAAWLAAQILALHDSKIKKQL 144
>UniRef50_Q94IQ2 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
synthase; n=1; Crypthecodinium cohnii|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
- Crypthecodinium cohnii (Dinoflagellate)
Length = 522
Score = 62.5 bits (145), Expect = 8e-09
Identities = 39/152 (25%), Positives = 67/152 (44%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V+I GS +D H + + K F + +R+ SAHK +++Q Y + ++ +
Sbjct: 356 VIIAAGSDSDMPHLETLKKELAKFKIPSQIRICSAHKQPGRLEQLIQAYNKSVEPIMLVG 415
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQDIWSSLSVPSGLGCATVIYPDSAALMAA 440
AG ++ L S + ++PV++CPP + L+ P G A ++ P + AA
Sbjct: 416 CAGGTDALSGTASYSATFPVVSCPPDGMNS-----TCLTNPPGSSNAFIVKPANVGKFAA 470
Query: 441 QIIGLQDYLIWARLRVKQLEMATALRLADQKL 536
Q + A L E L AD+ L
Sbjct: 471 QFFASHCPKVAAELEANIQEKIRKLEQADESL 502
>UniRef50_Q8A4S9 Cluster: Phosphoribosylaminoimidazole carboxylase;
n=4; Bacteroides|Rep: Phosphoribosylaminoimidazole
carboxylase - Bacteroides thetaiotaomicron
Length = 171
Score = 62.1 bits (144), Expect = 1e-08
Identities = 42/131 (32%), Positives = 66/131 (50%), Gaps = 4/131 (3%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D +K A+ D + ++ SAH+ T E + + + G V IA
Sbjct: 7 VSIIMGSTSDLPVMEKAAQLLNDMHVPFEMNALSAHR-TPEAVEEFAKNARSRGIKVIIA 65
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD--SAA 428
AG + L V++ NT+ PVI P L V ++S + +P G+ ATV +AA
Sbjct: 66 AAGMAAALPGVIAANTTLPVIGVPVKGSVLDGVDALYSIIQMPPGIPVATVAINGAMNAA 125
Query: 429 LMAAQIIGLQD 461
++A Q++ L D
Sbjct: 126 ILAIQMLALSD 136
>UniRef50_O58058 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=94; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Pyrococcus horikoshii
Length = 177
Score = 62.1 bits (144), Expect = 1e-08
Identities = 48/159 (30%), Positives = 82/159 (51%), Gaps = 4/159 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D ++ A+ +FG+ ++ + SAH+ E ++ E+ G V IA
Sbjct: 12 VGIIMGSDSDLPVMKEAARILEEFGVPYEITIISAHRTPERAYEYAKKAEE-RGIEVIIA 70
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD--SAA 428
AG + L +++ T PVI P S L + + S + +PSG+ ATV + +AA
Sbjct: 71 GAGGAAHLPGIIASLTVLPVIGVPIKSKALNGLDSLLSIVQMPSGIPVATVAIDNAKNAA 130
Query: 429 LMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLRNL 545
L+A +I+G++ I +LR +M R ++K + L
Sbjct: 131 LLALRILGIKYPEIKEKLRRYMKDMK---RKVEEKAKRL 166
>UniRef50_P41654 Cluster: Probable phosphoribosylaminoimidazole
carboxylase; n=2; Methanothermobacter thermautotrophicus
str. Delta H|Rep: Probable phosphoribosylaminoimidazole
carboxylase - Methanobacterium thermoautotrophicum
Length = 334
Score = 62.1 bits (144), Expect = 1e-08
Identities = 43/131 (32%), Positives = 67/131 (51%), Gaps = 3/131 (2%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V+I +GS +D ++K + + + DLRV SAH+ E+ I+ + G VFI
Sbjct: 4 RVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIVSEAVKA-GVEVFI 62
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQD---IWSSLSVPSGLGCATVIYPDSAA 428
+AG S L ++S NT PVI P D S + P+ + V ++AA
Sbjct: 63 GIAGLSAHLPGMISANTHRPVIGVPVDVKLGGLDALFACSQMPFPAPVATVGVDRGENAA 122
Query: 429 LMAAQIIGLQD 461
++AAQIIG+ D
Sbjct: 123 ILAAQIIGIGD 133
Score = 47.6 bits (108), Expect = 3e-04
Identities = 37/138 (26%), Positives = 70/138 (50%), Gaps = 3/138 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V + GS +D + ++K G+ DL V S + E R +++ E+ +FIA
Sbjct: 191 VSVIPGSYSDMKIAKKTTMFLERMGISYDLNVISPIRYPERFERYLEKMENVK---LFIA 247
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQD-IWSSLSVPSGLGCATVIYPD--SAAL 431
++G S + + + PVI P P D + S +++P G+ TV + +AA+
Sbjct: 248 ISGLSAHVTGAVVALSDRPVIGVPCPLKMNGWDSLLSMINMPPGVPVGTVGVGNGGNAAI 307
Query: 432 MAAQIIGLQDYLIWARLR 485
+AA+++G+ D I +R++
Sbjct: 308 LAAEMLGIYDEKIESRIK 325
>UniRef50_Q4AJE5 Cluster:
1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate
(AIR) carboxylase; n=2; Bacteria|Rep:
1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate
(AIR) carboxylase - Chlorobium phaeobacteroides BS1
Length = 174
Score = 61.7 bits (143), Expect = 1e-08
Identities = 50/157 (31%), Positives = 82/157 (52%), Gaps = 4/157 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D + ++ A +F + ++ V SAH+ T + L ++G + IA
Sbjct: 12 VGILMGSDSDFDIMKEAAAVLDEFSIPYEMSVISAHR-TPKDLEAYATQAKSNGLKIIIA 70
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKLV-QD-IWSSLSVPSGLGCATVIYPD--SAA 428
AG + L V + T PVI P + KL QD ++S + +P G+ ATV + + A
Sbjct: 71 GAGAAAHLPGVTAAFTVLPVIGVPIFNKKLSGQDSLYSIVQMPPGIPVATVGIDNARNGA 130
Query: 429 LMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLR 539
LMA I+ L D I + L + ++A A RL ++K++
Sbjct: 131 LMAVHILALTDPSIMSSLEEFREKLAEASRLKNRKVQ 167
>UniRef50_A0LLY4 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=1; Syntrophobacter fumaroxidans
MPOB|Rep: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit - Syntrophobacter fumaroxidans (strain
DSM 10017 / MPOB)
Length = 180
Score = 61.7 bits (143), Expect = 1e-08
Identities = 44/148 (29%), Positives = 74/148 (50%), Gaps = 6/148 (4%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V I MGS +D + + DF + ++R+ SAH++ +ET R G V I
Sbjct: 9 RVGILMGSESDLSVMESAFRILDDFEVPYEVRILSAHRSPDETARYADS-AGQRGVQVLI 67
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD---- 419
A AG + L V++ T+ PVI P S L + + +++ +P G+ AT+
Sbjct: 68 AGAGWAAHLAGVVASRTTLPVIGVPIDSSPLQGMDALLATVQMPPGIPVATMCIGRGGAL 127
Query: 420 SAALMAAQIIGLQDYLIWARLRVKQLEM 503
+AAL A QI+ L D + +L+ ++ M
Sbjct: 128 NAALFALQILALNDRTLDGKLKAYRVRM 155
>UniRef50_Q8PV25 Cluster: Phosphoribosylaminoimidazole carboxylase;
n=5; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase -
Methanosarcina mazei (Methanosarcina frisia)
Length = 169
Score = 60.9 bits (141), Expect = 3e-08
Identities = 39/130 (30%), Positives = 69/130 (53%), Gaps = 3/130 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
VVI +GS +D+E ++K + FG++ + V SAH+ I++ T FIA
Sbjct: 4 VVIILGSKSDKEVARKATEVFDRFGIEYTITVASAHRTPARLAEIIETAHKT-DVKAFIA 62
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSD-KLVQDIWSSLSVPSGL--GCATVIYPDSAAL 431
+AG S L V++ +T PVI P S + + S +P+G+ C + D+AA+
Sbjct: 63 IAGLSAHLPGVVASSTIKPVIGVPVNSALDGIDALLSIAQMPTGIPVACVGIGRGDNAAI 122
Query: 432 MAAQIIGLQD 461
+A Q++ +++
Sbjct: 123 LAVQLLAVEN 132
>UniRef50_P96880 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=58; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Mycobacterium tuberculosis
Length = 174
Score = 59.7 bits (138), Expect = 6e-08
Identities = 46/161 (28%), Positives = 80/161 (49%), Gaps = 4/161 (2%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V + MGS +D A A +F + ++RV SAH+ T E + + G V I
Sbjct: 9 RVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHR-TPEAMFSYARGAAERGLEVII 67
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIY--PDSA 425
A AG + L +++ T PVI P P +L + + S + +P+G+ ATV +A
Sbjct: 68 AGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGAGNA 127
Query: 426 ALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLRNLS 548
L+A +++G + + AR+ Q +A + D +L+ L+
Sbjct: 128 GLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAELQRLA 168
>UniRef50_Q7M7S1 Cluster: PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT; n=19; delta/epsilon subdivisions|Rep:
PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC
SUBUNIT - Wolinella succinogenes
Length = 164
Score = 59.3 bits (137), Expect = 8e-08
Identities = 45/161 (27%), Positives = 81/161 (50%), Gaps = 6/161 (3%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D E ++ A+ + F + ++ ++SAH++ T + + E GA VFIA
Sbjct: 4 VSILMGSKSDAEVMRECAEIFKKFDVPYEMIISSAHRSPVRTKEYVLEAE-ARGAKVFIA 62
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPDSAAL- 431
AG + L +S T+ PVI P L + + S++ +PSG+ TV + A+
Sbjct: 63 AAGMAAHLAGAISSMTTKPVIGVPMGGGTLGGLDALLSTVQMPSGMPVGTVAIGKTGAVN 122
Query: 432 ---MAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLRNL 545
+A QI+ L + + +L+ ++ A + L ++ L
Sbjct: 123 SAYLAMQILALGNDELAGKLKEDRVMKAKNVELDSAEIEVL 163
>UniRef50_Q2NEA3 Cluster: PurE; n=3; Archaea|Rep: PurE -
Methanosphaera stadtmanae (strain DSM 3091)
Length = 354
Score = 58.0 bits (134), Expect = 2e-07
Identities = 45/132 (34%), Positives = 66/132 (50%), Gaps = 4/132 (3%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
KV+I +GS +D + ++K K + DLRV SAH+ IM Y D G VFI
Sbjct: 19 KVMIILGSGSDYKIAEKTVKVFEQMKVPYDLRVASAHRTHNRIKDIMTNYVD--GIEVFI 76
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCAT--VIYPDSA 425
+AG S L V++ T+ PVI P + K+ + + S + G AT + ++A
Sbjct: 77 GIAGLSAHLPGVIASYTTKPVI-AVPVNGKIEGLDALLSCTEMQLGTPVATMGIDRGENA 135
Query: 426 ALMAAQIIGLQD 461
A +A QII D
Sbjct: 136 AWLACQIIACND 147
>UniRef50_Q74AP6 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=1; Geobacter sulfurreducens|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Geobacter sulfurreducens
Length = 183
Score = 57.6 bits (133), Expect = 2e-07
Identities = 40/130 (30%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I GSP D K+ + G+ ++ V SAH+ ++ L + + G V I
Sbjct: 20 VGILTGSPNDLPTVVKVRDTLTELGIPSEIVVASAHRTPDKVLAYLDR-AHKEGVQVLIG 78
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPDS--AA 428
AG + L V++G+T PVI P + L + + S++ +P G+ ATV S AA
Sbjct: 79 CAGVAAHLAGVIAGHTRLPVIGLPLGNGPLSGMDSLLSTVQMPPGVPVATVAIDGSRNAA 138
Query: 429 LMAAQIIGLQ 458
++AA+I+ L+
Sbjct: 139 MLAARILALK 148
>UniRef50_Q93J44 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit PurE; n=47; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit PurE - Streptomyces coelicolor
Length = 180
Score = 56.4 bits (130), Expect = 5e-07
Identities = 47/157 (29%), Positives = 75/157 (47%), Gaps = 4/157 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D + AKA +F + ++ V SAH+ E + +Q G IA
Sbjct: 11 VGIVMGSDSDWPVMEAAAKALDEFEVPYEVDVVSAHRMPHEMIAYGEQAAG-RGLKAIIA 69
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIY--PDSAA 428
AG + L +L+ T PVI P P L + + S + +P+G+ ATV +A
Sbjct: 70 GAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVATVSVGGARNAG 129
Query: 429 LMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLR 539
L+AA+I+ D + R+R Q ++ ++LR
Sbjct: 130 LLAARILAAHDEELLGRMREFQQDLNDQATEKGKRLR 166
>UniRef50_Q8XMK7 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=11; Clostridium|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Clostridium perfringens
Length = 159
Score = 56.4 bits (130), Expect = 5e-07
Identities = 39/130 (30%), Positives = 68/130 (52%), Gaps = 3/130 (2%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
KV IF GS +D + + A ++FG+ + + SAH+ E+ + +++ E G V I
Sbjct: 2 KVAIFFGSKSDIDVMKGAGNALKEFGIPYNAYILSAHRVPEKLIETLEKIE-KEGCEVII 60
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQD-IWSSLSVPSGLGCATVIYPDS--AA 428
A AG + L V++ +T PVI P + D + S + +P + ATV +S A
Sbjct: 61 AGAGLAAHLPGVIASHTILPVIGVPVRAAVEGMDALLSIVQMPKSIPVATVGINNSYNAG 120
Query: 429 LMAAQIIGLQ 458
++A Q++ L+
Sbjct: 121 MLAVQMLSLK 130
>UniRef50_A0JU62 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=4; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Arthrobacter sp. (strain FB24)
Length = 196
Score = 56.4 bits (130), Expect = 5e-07
Identities = 46/149 (30%), Positives = 72/149 (48%), Gaps = 4/149 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V + MGS +D + A+A +FG+ + V SAH+ E +R Q + G V IA
Sbjct: 19 VGLVMGSDSDWPVMEAAAEALAEFGIPFEADVVSAHRMPTEMIRYGQTAHE-RGLRVIIA 77
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD--SAA 428
AG + L +L+ T PVI P P L + + S + +P+G+ ATV +A
Sbjct: 78 GAGGAAHLPGMLASVTPLPVIGVPVPLKTLDGMDSLLSIVQMPAGVPVATVSIAGARNAG 137
Query: 429 LMAAQIIGLQDYLIWARLRVKQLEMATAL 515
L+A +++ + RLR +E A L
Sbjct: 138 LLAVRMLASGTDDLAVRLRDDLIEFAQEL 166
>UniRef50_Q5XEE9 Cluster: Phosphoribosylaminoimidazole carboxylase
carboxyltransferase subunit; n=18; Streptococcus|Rep:
Phosphoribosylaminoimidazole carboxylase
carboxyltransferase subunit - Streptococcus pyogenes
serotype M6
Length = 203
Score = 55.2 bits (127), Expect = 1e-06
Identities = 38/133 (28%), Positives = 69/133 (51%), Gaps = 6/133 (4%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
+ I MGS +D QK A+ +FG+ + +V SAH+ + + ++ G + IA
Sbjct: 46 ISIIMGSKSDWATMQKTAEILDNFGIAYEKKVVSAHRTPDLMFKHAEEARG-RGIKIIIA 104
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD----S 422
AG + L +++ T+ PVI P S L + ++S + +P G+ AT+ + +
Sbjct: 105 GAGGAAHLPGMVAAKTTLPVIGVPVKSRVLSGLDSLYSIVQMPGGVPVATMAIGEAGATN 164
Query: 423 AALMAAQIIGLQD 461
AAL A +I+ ++D
Sbjct: 165 AALTALRILSIED 177
>UniRef50_Q11CU3 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=19; Bacteria|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Mesorhizobium sp. (strain BNC1)
Length = 165
Score = 55.2 bits (127), Expect = 1e-06
Identities = 46/140 (32%), Positives = 67/140 (47%), Gaps = 6/140 (4%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D E + A + D+R+ SAH+ T + L + G V IA
Sbjct: 8 VAIIMGSQSDWETMRHAADILETLEISHDVRIVSAHR-TPDRLYAFAKGAKAEGIRVIIA 66
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKLV-QD-IWSSLSVPSGLGCATVIYPDS---- 422
AG + L + + TS PV P S L QD + S + +P+G+ T+ S
Sbjct: 67 GAGGAAHLPGMTAALTSLPVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRSGAVN 126
Query: 423 AALMAAQIIGLQDYLIWARL 482
AAL+AA ++ L D + ARL
Sbjct: 127 AALLAAAVLALSDEALAARL 146
>UniRef50_A1T5T8 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=7; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Mycobacterium vanbaalenii (strain DSM 7251 /
PYR-1)
Length = 166
Score = 55.2 bits (127), Expect = 1e-06
Identities = 44/158 (27%), Positives = 74/158 (46%), Gaps = 4/158 (2%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V + MGS +D + A+A +F + ++ V SAH+ L G V I
Sbjct: 4 RVGLIMGSDSDWPVMSEAAEALAEFDVPFEVGVVSAHRTPARMLSYAADAAG-RGLEVII 62
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIY--PDSA 425
A AG + L +++ T PVI P P +L + + S + +P+G+ ATV +A
Sbjct: 63 AGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNA 122
Query: 426 ALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLR 539
L+A +I+G D + R+ Q + + D+ LR
Sbjct: 123 GLLAVRILGAADGALRDRMAAYQASLEQMVLQKDEALR 160
>UniRef50_P21264 Cluster: Phosphoribosylaminoimidazole carboxylase;
n=62; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase - Saccharomyces
cerevisiae (Baker's yeast)
Length = 571
Score = 54.8 bits (126), Expect = 2e-06
Identities = 48/174 (27%), Positives = 78/174 (44%), Gaps = 4/174 (2%)
Frame = +3
Query: 36 VREQLDHLKPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRI 215
V ++LD L+ V V I MGS +D +DFG+ ++ + SAH+ T +
Sbjct: 391 VAQKLD-LEAMVKPLVGIIMGSDSDLPVMSAACAVLKDFGVPFEVTIVSAHR-TPHRMSA 448
Query: 216 MQQYEDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSG 389
G IA AG + L +++ T PVI P L V + S + +P G
Sbjct: 449 YAISASKRGIKTIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSCLDGVDSLHSIVQMPRG 508
Query: 390 LGCATVIYPDS--AALMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLRNL 545
+ ATV +S AAL+A +++G D ++ L+ + + QKL +
Sbjct: 509 VPVATVAINNSTNAALLAVRLLGAYDSSYTTKMEQFLLKQEEEVLVKAQKLETV 562
>UniRef50_A2SPX9 Cluster:
1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate
(AIR) carboxylase; n=1; Methanocorpusculum labreanum
Z|Rep:
1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate
(AIR) carboxylase - Methanocorpusculum labreanum (strain
ATCC 43576 / DSM 4855 / Z)
Length = 129
Score = 54.4 bits (125), Expect = 2e-06
Identities = 38/130 (29%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V + GS +DQ K + + + D++ SAH+ ++ + +Y + AL+FI
Sbjct: 3 EVAVIAGSVSDQAIVDKATAVLQSYNISFDVQFISAHRDADK----LDEYVKSSDALIFI 58
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQDIWSSLSV---PSG--LGCATVIYPDS 422
+AG S L V++ T PVI P S K+ + + LS+ P G + C V ++
Sbjct: 59 CIAGMSAALPGVVAARTKKPVIGV-PVSGKIAGGLDALLSIAQMPKGVPVACMAVDGGEN 117
Query: 423 AALMAAQIIG 452
A AA+I+G
Sbjct: 118 AGHFAARILG 127
>UniRef50_P22348 Cluster: Probable phosphoribosylaminoimidazole
carboxylase; n=9; Euryarchaeota|Rep: Probable
phosphoribosylaminoimidazole carboxylase -
Methanobrevibacter smithii
Length = 339
Score = 54.4 bits (125), Expect = 2e-06
Identities = 41/131 (31%), Positives = 66/131 (50%), Gaps = 3/131 (2%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
KV+I +GS +D ++K K + L++ SAH+ T + +R + G VFI
Sbjct: 4 KVMIILGSGSDIAIAEKSMKILEKLEIPYSLKIASAHR-TPDLVRELVVQGTNAGIKVFI 62
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQD-IWSSLSVPSGLGCATVIYP--DSAA 428
+AG + L ++ T PVI P D ++SS+ +P ATV D+ A
Sbjct: 63 GIAGLAAHLPGAIAAYTHKPVIGVPVDVKVSGLDALYSSVQMPYPSPVATVGIDRGDNGA 122
Query: 429 LMAAQIIGLQD 461
++AA+I+GL D
Sbjct: 123 ILAARILGLYD 133
Score = 33.9 bits (74), Expect = 3.3
Identities = 30/131 (22%), Positives = 65/131 (49%), Gaps = 3/131 (2%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDT-HGALVF 254
+VVI +G D +K++ + D++V ++ ++ + Y +T A +F
Sbjct: 196 EVVIIVGRHTDLITGKKVSVTLDRLKIPHDMQVICPIRSGKK----FRAYVNTMKNAKIF 251
Query: 255 IAVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQDIWSSLSVPSGLGCATVIYPD--SAA 428
I + S+ + L G T PVI P ++ + S++++P G+ ATV + +AA
Sbjct: 252 IGINSNSSQVSGGLVGLTEKPVIGVPCENELGNNYLLSTVNMPPGVPVATVGVNNGRNAA 311
Query: 429 LMAAQIIGLQD 461
+++ +I+ + +
Sbjct: 312 VLSGEILSINN 322
>UniRef50_Q55498 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=200; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Synechocystis sp. (strain PCC 6803)
Length = 176
Score = 50.0 bits (114), Expect = 5e-05
Identities = 39/159 (24%), Positives = 72/159 (45%), Gaps = 4/159 (2%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D +F + ++ + SAH+ E + Q G + IA
Sbjct: 8 VGIIMGSDSDLPTMAAAIAVCEEFAVPTEVAIISAHRTPERMVEYAQTAHQ-RGLRIIIA 66
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD--SAA 428
AG + L +++ T PVI P + L V ++S + +P G+ ATV + +A
Sbjct: 67 GAGGAAHLPGMVAALTPLPVIGVPVQTKTLQGVDSLYSIVQMPGGIPVATVAIGNAKNAG 126
Query: 429 LMAAQIIGLQDYLIWARLRVKQLEMATALRLADQKLRNL 545
L+A QI+ + ++ +++ + + T + +L L
Sbjct: 127 LLAVQILASHNPVLLEKVQQYRQSLETMVLDKQAELERL 165
>UniRef50_Q2J4S5 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=3; Frankia|Rep:
Phosphoribosylaminoimidazole carboxylase, catalytic
subunit - Frankia sp. (strain CcI3)
Length = 174
Score = 49.6 bits (113), Expect = 6e-05
Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 4/134 (2%)
Frame = +3
Query: 72 HHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALV 251
H +V I GSP+D + K FG+ + SAH+A + Q V
Sbjct: 10 HPQVAIVFGSPSDTQTMSKAGATLERFGVPYEQVSLSAHRAPRTLADYVGQLR-ARDISV 68
Query: 252 FIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPDS- 422
IA AG + L ++ T+ PVI P L + + + +P G+ ATV +S
Sbjct: 69 VIAGAGLAAALPGTIAALTTLPVIGVPISGGALDGMDSLLAIAQMPPGVPVATVGLNNST 128
Query: 423 -AALMAAQIIGLQD 461
AA++A QI+ L D
Sbjct: 129 NAAILAIQILALAD 142
>UniRef50_Q6NRP1 Cluster: LOC431975 protein; n=2; Xenopus|Rep:
LOC431975 protein - Xenopus laevis (African clawed frog)
Length = 371
Score = 48.4 bits (110), Expect = 1e-04
Identities = 21/51 (41%), Positives = 33/51 (64%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYE 230
+VV+ M S +D H ++I K+ +G+ +LRV SAH +ETL I+ +YE
Sbjct: 305 RVVLLMESTSDLAHCEEIKKSCTKYGMKCELRVASAHTGPQETLDILAEYE 355
>UniRef50_P72157 Cluster: Phosphoribosylaminoimidazole carboxylase
catalytic subunit; n=126; Bacteria|Rep:
Phosphoribosylaminoimidazole carboxylase catalytic
subunit - Pseudomonas aeruginosa
Length = 163
Score = 48.0 bits (109), Expect = 2e-04
Identities = 37/130 (28%), Positives = 62/130 (47%), Gaps = 6/130 (4%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V + MGS +D A G+ +++V SAH+ + + ++ E G V IA
Sbjct: 5 VGVIMGSKSDWSTLSHTADMLDKLGIPYEVKVVSAHRTPDLLFQYAEEAEG-RGLEVIIA 63
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATVIYPD----S 422
AG + L + + T PV+ P S L V + S + +P+G+ AT+ +
Sbjct: 64 GAGGAAHLPGMCAAKTHLPVLGVPVQSSMLSGVDSLLSIVQMPAGVPVATLAIGKAGAVN 123
Query: 423 AALMAAQIIG 452
AAL++A I+G
Sbjct: 124 AALLSASILG 133
>UniRef50_A4M8A1 Cluster:
1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate
(AIR) carboxylase; n=1; Petrotoga mobilis SJ95|Rep:
1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate
(AIR) carboxylase - Petrotoga mobilis SJ95
Length = 139
Score = 47.6 bits (108), Expect = 3e-04
Identities = 30/112 (26%), Positives = 57/112 (50%), Gaps = 2/112 (1%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
KV++ GS +D+ + ++ + D +V SAH+ +E + +++ ++ I
Sbjct: 4 KVLLISGSQSDEIFVKTAIDLFEEWKISYDYKVFSAHRNLKELTKFIEELPSNEYCVI-I 62
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCATV 407
AVAG S L V++ T+ PV+ P L + + S + +PSG+ AT+
Sbjct: 63 AVAGLSAALPGVIASLTNLPVVGVPRDVGPLNGIDALLSMVQMPSGVPVATM 114
>UniRef50_P15567 Cluster: Phosphoribosylaminoimidazole carboxylase;
n=53; cellular organisms|Rep:
Phosphoribosylaminoimidazole carboxylase -
Schizosaccharomyces pombe (Fission yeast)
Length = 552
Score = 47.6 bits (108), Expect = 3e-04
Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 4/138 (2%)
Frame = +3
Query: 48 LDHLKPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQY 227
LD P V I MGS +D + A +F + +L + SAH+ T + + +
Sbjct: 377 LDVKDPVESPVVGIIMGSDSDLSKMKDAAVILDEFKVPYELTIVSAHR-TPDRMVTYART 435
Query: 228 EDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKL--VQDIWSSLSVPSGLGCA 401
+ G V IA AG + L +++ T PVI P L V + S + +P G+ A
Sbjct: 436 AASRGLRVIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSTLDGVDSLHSIVQMPRGVPVA 495
Query: 402 TVIYPDS--AALMAAQII 449
TV +S A ++A +I+
Sbjct: 496 TVAINNSQNAGILACRIL 513
>UniRef50_Q98FE6 Cluster: Phosphoribosylaminoimidazole carboxylase
I; n=5; Proteobacteria|Rep: Phosphoribosylaminoimidazole
carboxylase I - Rhizobium loti (Mesorhizobium loti)
Length = 165
Score = 42.3 bits (95), Expect = 0.009
Identities = 41/140 (29%), Positives = 64/140 (45%), Gaps = 6/140 (4%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D ++ A+ G+ + SAH+ T + L + G V IA
Sbjct: 8 VAIIMGSQSDWATMRQAAETLEALGVPHKRLIISAHR-TPDRLYEFAKGAKAAGYKVIIA 66
Query: 261 VAGRSNGLGPVLSGNTSYPVINCPPPSDKLV-QD-IWSSLSVPSGLGCATVIY----PDS 422
AG + L + + T PV P S L QD + S + +P+G+ T+ +
Sbjct: 67 GAGGAAHLPGMTAAMTPLPVFGVPVESKALSGQDSLLSIVQMPAGIPVGTLAIGKAGAAN 126
Query: 423 AALMAAQIIGLQDYLIWARL 482
AAL+AA ++ L D + RL
Sbjct: 127 AALLAAAVLALNDDKLAQRL 146
>UniRef50_A7D0F6 Cluster: NCAIR mutase (PurE)-related protein; n=1;
Halorubrum lacusprofundi ATCC 49239|Rep: NCAIR mutase
(PurE)-related protein - Halorubrum lacusprofundi ATCC
49239
Length = 260
Score = 37.9 bits (84), Expect = 0.20
Identities = 27/94 (28%), Positives = 43/94 (45%)
Frame = +3
Query: 51 DHLKPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYE 230
D +P ++ V + AD + + A AR+ G +D R+ A + RI+ Q +
Sbjct: 117 DFERPDLNATVAVVAAGTADAAVAGEAAVVAREIGATID-RIDDVGVANLD--RILDQRD 173
Query: 231 DTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCP 332
A V + AGR L V++G + PVI P
Sbjct: 174 RIREADVVVVAAGREGALPTVVAGLVAAPVIALP 207
>UniRef50_A7DMC3 Cluster: Phosphoribosylaminoimidazole carboxylase,
catalytic subunit; n=1; Candidatus Nitrosopumilus
maritimus SCM1|Rep: Phosphoribosylaminoimidazole
carboxylase, catalytic subunit - Candidatus
Nitrosopumilus maritimus SCM1
Length = 191
Score = 37.1 bits (82), Expect = 0.36
Identities = 26/84 (30%), Positives = 42/84 (50%)
Frame = +3
Query: 81 VVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIA 260
V I MGS +D + A+ DF + + ++ SAH+ T L Q+ + G + IA
Sbjct: 9 VGIIMGSSSDSRIMKGAAEILDDFKVKHEDQIISAHR-TPARLAEYAQHAEKMGFDIIIA 67
Query: 261 VAGRSNGLGPVLSGNTSYPVINCP 332
AG + L +++ +T PVI P
Sbjct: 68 GAGGAAHLPGMIASHTVIPVIGVP 91
>UniRef50_Q6BIQ2 Cluster: Similar to CA4826|IPF1206 Candida albicans
IPF1206 unknown function; n=1; Debaryomyces
hansenii|Rep: Similar to CA4826|IPF1206 Candida albicans
IPF1206 unknown function - Debaryomyces hansenii (Yeast)
(Torulaspora hansenii)
Length = 556
Score = 36.3 bits (80), Expect = 0.62
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Frame = +3
Query: 195 TEETLRIMQQYEDTHGALV-FIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQDIWSS 371
TE+ +I Y T+G +V FI + + P L P PPP K+ Q ++SS
Sbjct: 149 TEDFNKISVSYNLTNGEVVTFIYKSEEPSSSMPPLPNAYHSPYPQPPPPPQKIKQPLFSS 208
Query: 372 LSVPSGLGCATVIYPD 419
L+ S L + I PD
Sbjct: 209 LTGKSNLDPRSTIVPD 224
>UniRef50_A0RWQ1 Cluster: Phosphoribosylcarboxyaminoimidazole
(NCAIR) mutase; n=1; Cenarchaeum symbiosum|Rep:
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase -
Cenarchaeum symbiosum
Length = 181
Score = 36.3 bits (80), Expect = 0.62
Identities = 26/85 (30%), Positives = 42/85 (49%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFI 257
+V I MGS +D + A+ FG+ + + SAH+ T E L ++ + G V I
Sbjct: 8 EVGIIMGSSSDARIMLEAARVLDGFGVLHEDLIVSAHR-TPERLGDYARHAEEIGLRVII 66
Query: 258 AVAGRSNGLGPVLSGNTSYPVINCP 332
A AG + L +++ T PV+ P
Sbjct: 67 AGAGGAAHLPGMIASYTVVPVVGVP 91
>UniRef50_Q0RZB9 Cluster: Amino acid decarboxylase; n=9;
Actinomycetales|Rep: Amino acid decarboxylase -
Rhodococcus sp. (strain RHA1)
Length = 489
Score = 34.7 bits (76), Expect = 1.9
Identities = 28/62 (45%), Positives = 33/62 (53%)
Frame = -2
Query: 275 RAASNGDKYESAMRILILLHDAKRFLRGFVS*CHSEVHVQAEVAGGFGNFLAMLLVSRRS 96
R +SNG Y S R L+ DA R R F S C S + V+A + GN LLVSR S
Sbjct: 60 RRSSNG--YLS--RAEQLMADAVRAERAFFSTCGSSLSVKAAMLAVAGNDPGGLLVSRDS 115
Query: 95 HK 90
HK
Sbjct: 116 HK 117
>UniRef50_A3S2A4 Cluster: ATP-dependent exoDNAse alpha subunit; n=1;
Prochlorococcus marinus str. MIT 9211|Rep: ATP-dependent
exoDNAse alpha subunit - Prochlorococcus marinus str.
MIT 9211
Length = 574
Score = 34.3 bits (75), Expect = 2.5
Identities = 18/78 (23%), Positives = 34/78 (43%)
Frame = +3
Query: 3 DLDTVKRNFAWVREQLDHLKPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTS 182
D D +K EQL L+ H +V+ G P + S + + +D++LR+
Sbjct: 128 DKDAIKSTVKLNSEQLLALESITSHNLVLLSGGPGTGKTSTIVEMLRKSLSIDLELRIGL 187
Query: 183 AHKATEETLRIMQQYEDT 236
A + T R+ + + +
Sbjct: 188 AAPTGKATRRLQESLQSS 205
>UniRef50_Q9YBE5 Cluster: PqqE homolog; n=4; Thermoprotei|Rep: PqqE
homolog - Aeropyrum pernix
Length = 389
Score = 34.3 bits (75), Expect = 2.5
Identities = 22/69 (31%), Positives = 36/69 (52%)
Frame = +3
Query: 27 FAWVREQLDHLKPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRVTSAHKATEET 206
F++V LD + P VH K F G+P + + + A+ A + GLDV R+T ++
Sbjct: 135 FSYVGISLDSVDPGVHDK---FRGAPGAFKAAIRGARNALEEGLDVGFRLTITKYNLDDA 191
Query: 207 LRIMQQYED 233
RI++ D
Sbjct: 192 PRIIRLASD 200
>UniRef50_O28993 Cluster: Putative uncharacterized protein; n=1;
Archaeoglobus fulgidus|Rep: Putative uncharacterized
protein - Archaeoglobus fulgidus
Length = 229
Score = 34.3 bits (75), Expect = 2.5
Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Frame = +3
Query: 78 KVVIFMGSPADQEHSQKIAKAARDFGLDV----DLRVTSAHKATEETLRIMQQYEDTHGA 245
KV I +D +++ A A GL+V D+ V H+ E RI ++ D+
Sbjct: 91 KVAILTAGTSDIPVAEEAAVTAEFLGLEVLRFYDVGVAGLHRIVEPVKRIREENVDSA-- 148
Query: 246 LVFIAVAGRSNGLGPVLSGNTSYPVINCP 332
I VAG L V++G PVI P
Sbjct: 149 ---IVVAGMEGALPSVIAGLVDVPVIAVP 174
>UniRef50_A7H038 Cluster: Ncair mutase; n=8; Bacteria|Rep: Ncair
mutase - Campylobacter curvus 525.92
Length = 248
Score = 33.9 bits (74), Expect = 3.3
Identities = 17/41 (41%), Positives = 22/41 (53%)
Frame = +3
Query: 210 RIMQQYEDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCP 332
R+ + +D GA V IAVAG L V++G PVI P
Sbjct: 161 RLFSKLDDIQGARVVIAVAGMEGALPSVIAGLVKAPVIAVP 201
>UniRef50_Q7VX63 Cluster: Putative hemin storage protein; n=3;
Bordetella|Rep: Putative hemin storage protein -
Bordetella pertussis
Length = 661
Score = 33.5 bits (73), Expect = 4.4
Identities = 14/31 (45%), Positives = 17/31 (54%)
Frame = +2
Query: 446 HRFTGLSDLGSSKSEAARNGYSLETRRSETQ 538
H+FTG +DLG RNG LE RR +
Sbjct: 415 HQFTGYADLGDGHKSRVRNGAGLEYRRGSIE 445
>UniRef50_A4G5F2 Cluster: Universal stress protein; n=4;
Herminiimonas arsenicoxydans|Rep: Universal stress
protein - Herminiimonas arsenicoxydans
Length = 143
Score = 33.1 bits (72), Expect = 5.8
Identities = 20/71 (28%), Positives = 36/71 (50%)
Frame = +3
Query: 111 QEHSQKIAKAARDFGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIAVAGRSNGLGP 290
+++ KIA A G+D ++ V A++E ++ +Y H +F+A GR GL
Sbjct: 66 EKYVHKIATHAASLGVDAEVHVVEGTSASDEIIKAADKY---HCDAIFMASHGR-KGLDK 121
Query: 291 VLSGNTSYPVI 323
L G+ + V+
Sbjct: 122 FLLGSEAQKVL 132
>UniRef50_Q9VIK2 Cluster: CG9317-PA, isoform A; n=7;
Endopterygota|Rep: CG9317-PA, isoform A - Drosophila
melanogaster (Fruit fly)
Length = 674
Score = 33.1 bits (72), Expect = 5.8
Identities = 31/111 (27%), Positives = 49/111 (44%), Gaps = 8/111 (7%)
Frame = +3
Query: 303 NTSYPVINCPPPSDKLVQDIWSSLSVPSGLGCATVIYP--DSAALMAAQIIGLQDYLIWA 476
N S+P+I CP + +WSS+ + L C IYP AAL +G+ + +
Sbjct: 141 NASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLN 200
Query: 477 RLRVKQLE--MATALRLADQKLRNLSV*VFTLQHSRIFLYF----VYMSPF 611
++L + A LA + +LS +T SR+ + VY PF
Sbjct: 201 DRGGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPF 251
>UniRef50_Q6LHZ9 Cluster: Putative uncharacterized protein VPA0161;
n=2; Photobacterium profundum|Rep: Putative
uncharacterized protein VPA0161 - Photobacterium
profundum (Photobacterium sp. (strain SS9))
Length = 194
Score = 32.7 bits (71), Expect = 7.7
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Frame = +3
Query: 363 WSSLSVPSGLGCATVIYPDSAALMAAQIIGLQDYLIWAR-LRVKQLEMATALRLADQKLR 539
W +LS+ L AT++ P A +A Q + + Y I + L + L M LRLA +++R
Sbjct: 17 WIALSIALILAVATLLLPYHQAAIAQQAV--KSYQISIKDLDTESLAMIAELRLAHEEIR 74
Query: 540 NL 545
N+
Sbjct: 75 NI 76
>UniRef50_Q8RJP6 Cluster: Putative uncharacterized protein; n=11;
Xanthomonas|Rep: Putative uncharacterized protein -
Xanthomonas euvesicatoria
Length = 339
Score = 32.7 bits (71), Expect = 7.7
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Frame = +3
Query: 180 SAHKATEETLRIMQQYEDTHGALV--FIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKLV 353
+A A + T R++ T+G + + AGR G+ VL+ S + P
Sbjct: 138 AARDAIQATFRMVGMRSPTNGGVSDPHVTSAGRFYGMANVLTNLASNEL---EAPDFASA 194
Query: 354 QDIWSSLSVPSGLGCATVIYPDSAALMAAQIIGLQ 458
+ W+ L P +G AT + AA+ AA +GL+
Sbjct: 195 RQRWAGLMSPFNMGEATRVVFQQAAVNAALNVGLE 229
>UniRef50_A3XH86 Cluster: Peptidase, M20/M25/M40 family protein;
n=1; Leeuwenhoekiella blandensis MED217|Rep: Peptidase,
M20/M25/M40 family protein - Leeuwenhoekiella blandensis
MED217
Length = 768
Score = 32.7 bits (71), Expect = 7.7
Identities = 22/66 (33%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Frame = +3
Query: 3 DLDTVKRNFAWVR--EQLDHLKPAVHHKVVIFMGSPADQEHSQKIAKAARDFGLDVDLRV 176
DLDT + F+ R + LD + H +G PA QE I D+GL+++L+
Sbjct: 32 DLDTPETEFSTARAFQLLDSIAQKPHA-----VGMPAHQEVQDFIVAKLEDYGLEIELQS 86
Query: 177 TSAHKA 194
A+KA
Sbjct: 87 DFAYKA 92
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 670,569,096
Number of Sequences: 1657284
Number of extensions: 13727062
Number of successful extensions: 38308
Number of sequences better than 10.0: 50
Number of HSP's better than 10.0 without gapping: 37037
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 38271
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 47711253245
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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