Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I09A02NGRL0005_O06
(560 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 154 2e-37
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 154 2e-37
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 154 2e-37
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 154 2e-37
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 141 2e-33
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 139 5e-33
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 139 5e-33
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 134 2e-31
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 134 2e-31
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 134 2e-31
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 131 1e-30
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 124 3e-28
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 120 3e-27
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 99 5e-21
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 99 5e-21
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 99 5e-21
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 99 5e-21
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 99 5e-21
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 99 5e-21
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 61 2e-09
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 61 2e-09
X90568-1|CAA62188.1|26926|Homo sapiens titin protein. 29 8.5
AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein. 29 8.5
AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein. 29 8.5
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 154 bits (373), Expect = 2e-37
Identities = 80/164 (48%), Positives = 111/164 (67%), Gaps = 3/164 (1%)
Frame = +2
Query: 77 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 253
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 254 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 427
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 428 GAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
GAELD+DHPGF DPVYRARRK FADIAYNY+HGQ +P V+Y +E
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEE 182
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 154 bits (373), Expect = 2e-37
Identities = 80/164 (48%), Positives = 111/164 (67%), Gaps = 3/164 (1%)
Frame = +2
Query: 77 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 253
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 254 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 427
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 428 GAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
GAELD+DHPGF DPVYRARRK FADIAYNY+HGQ +P V+Y +E
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEE 182
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 154 bits (373), Expect = 2e-37
Identities = 80/164 (48%), Positives = 111/164 (67%), Gaps = 3/164 (1%)
Frame = +2
Query: 77 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 253
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 254 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 427
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 428 GAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
GAELD+DHPGF DPVYRARRK FADIAYNY+HGQ +P V+Y +E
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEE 182
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 154 bits (373), Expect = 2e-37
Identities = 80/164 (48%), Positives = 111/164 (67%), Gaps = 3/164 (1%)
Frame = +2
Query: 77 NYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSA-RRPGYEFM 253
+YI + + + L+FS +E G+LA+ L +F + VNL+HIESR S ++ YEF
Sbjct: 23 SYIEDNCNQNGAISLIFS--LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFF 80
Query: 254 VECE-HGAGDFGTALEELKKNVGY-LNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSY 427
+ ++ L+ ++G ++ +SR+ K + VPWFPR I++LDRFANQILSY
Sbjct: 81 THLDKRSLPALTNIIKILRHDIGATVHELSRDKK--KDTVPWFPRTIQELDRFANQILSY 138
Query: 428 GAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
GAELD+DHPGF DPVYRARRK FADIAYNY+HGQ +P V+Y +E
Sbjct: 139 GAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEE 182
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 141 bits (341), Expect = 2e-33
Identities = 72/152 (47%), Positives = 95/152 (62%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 295
L+FS +E G L + L IF VNL HIESR S RR +E V+C+ L
Sbjct: 18 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIL 75
Query: 296 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 76 HLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 135
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRKYFAD+A NYKHG +P V++T+E
Sbjct: 136 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEE 167
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 139 bits (337), Expect = 5e-33
Identities = 71/152 (46%), Positives = 94/152 (61%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 295
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIF 77
Query: 296 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRKYFAD+A NYKHG +P V++T+E
Sbjct: 138 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEE 169
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 139 bits (337), Expect = 5e-33
Identities = 71/152 (46%), Positives = 94/152 (61%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 295
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIF 77
Query: 296 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRKYFAD+A NYKHG +P V++T+E
Sbjct: 138 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEE 169
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 134 bits (325), Expect = 2e-31
Identities = 76/182 (41%), Positives = 106/182 (58%), Gaps = 5/182 (2%)
Frame = +2
Query: 29 KPTISPSDKPKLMEGGNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSH 208
KP +D K +G N RE + T ++FS +E G L + L +F VN+ H
Sbjct: 38 KPNSGKNDD-KGNKGSNK-REAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVH 93
Query: 209 IESRSSARRPG-YEFMVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPW 373
IESR S RR E V+CE G +F ++ LK + LN + + VPW
Sbjct: 94 IESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPW 153
Query: 374 FPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYT 553
FPR+I +LD+ ++++L YG+ELD+DHPGF D VYR RRKYF D+A YK+GQ +P V+YT
Sbjct: 154 FPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYT 213
Query: 554 KE 559
+E
Sbjct: 214 EE 215
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 134 bits (324), Expect = 2e-31
Identities = 71/167 (42%), Positives = 100/167 (59%), Gaps = 5/167 (2%)
Frame = +2
Query: 74 GNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEF 250
G+ RE + T ++FS +E G L + L +F VN+ HIESR S RR E
Sbjct: 57 GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEI 114
Query: 251 MVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPWFPRRIRDLDRFANQI 418
V+CE G +F ++ LK + LN + + VPWFPR+I +LD+ ++++
Sbjct: 115 FVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRV 174
Query: 419 LSYGAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
L YG+ELD+DHPGF D VYR RRKYF D+A YK+GQ +P V+YT+E
Sbjct: 175 LMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEE 221
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 134 bits (324), Expect = 2e-31
Identities = 71/167 (42%), Positives = 100/167 (59%), Gaps = 5/167 (2%)
Frame = +2
Query: 74 GNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEF 250
G+ RE + T ++FS +E G L + L +F VN+ HIESR S RR E
Sbjct: 51 GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEI 108
Query: 251 MVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPWFPRRIRDLDRFANQI 418
V+CE G +F ++ LK + LN + + VPWFPR+I +LD+ ++++
Sbjct: 109 FVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRV 168
Query: 419 LSYGAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
L YG+ELD+DHPGF D VYR RRKYF D+A YK+GQ +P V+YT+E
Sbjct: 169 LMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEE 215
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 131 bits (317), Expect = 1e-30
Identities = 68/152 (44%), Positives = 93/152 (61%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 295
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIF 77
Query: 296 EELKKNVGYLNIISR-NY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
LK + L++ N+ ++ +VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRKYFAD A +YK+G +P V++T+E
Sbjct: 138 DNVYRKRRKYFADSAMSYKYGDPIPKVEFTEE 169
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 124 bits (298), Expect = 3e-28
Identities = 66/146 (45%), Positives = 85/146 (58%), Gaps = 5/146 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEFMVECEHGAGDFGTAL 295
L+FS +E G L + L IF VNL HIESR S RR +E V+C+
Sbjct: 20 LIFS--LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIF 77
Query: 296 EELKKNVGYLNI-ISRNY---KDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
LK + L++ + N+ +D VPWFP++I DLD AN++L YG+ELD+DHPGF
Sbjct: 78 HLLKSHTNVLSVNLPDNFTLNEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
Query: 464 DPVYRARRKYFADIAYNYKHGQALPH 541
D VYR RRKYFAD+A NYK H
Sbjct: 138 DNVYRKRRKYFADLAMNYKQAYRFFH 163
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 120 bits (289), Expect = 3e-27
Identities = 66/159 (41%), Positives = 92/159 (57%), Gaps = 5/159 (3%)
Frame = +2
Query: 74 GNYIREGRDSTKSTWLLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARRPG-YEF 250
G+ RE + T ++FS +E G L + L +F VN+ HIESR S RR E
Sbjct: 51 GSSKREAATESGKTAVVFS--LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEI 108
Query: 251 MVECEHGAGDFGTALEELK--KNVGYLNIISRNYKDNRSA--VPWFPRRIRDLDRFANQI 418
V+CE G +F ++ LK + LN + + VPWFPR+I +LD+ ++++
Sbjct: 109 FVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRV 168
Query: 419 LSYGAELDSDHPGFTDPVYRARRKYFADIAYNYKHGQAL 535
L YG+ELD+DHPGF D VYR RRKYF D+A YK+G L
Sbjct: 169 LMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGPRL 207
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 99 bits (238), Expect = 5e-21
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 286
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 111 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 169
Query: 287 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 170 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 222
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 223 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 254
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 99 bits (238), Expect = 5e-21
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 286
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 287 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 227
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 99 bits (238), Expect = 5e-21
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 286
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 115 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 173
Query: 287 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 174 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 226
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 227 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 258
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 99 bits (238), Expect = 5e-21
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 286
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 88 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 146
Query: 287 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 147 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 199
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 200 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 231
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 99 bits (238), Expect = 5e-21
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 286
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 287 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 227
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 99 bits (238), Expect = 5e-21
Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +2
Query: 119 LLFSPATPDEAGSLARFLSIFCSHGVNLSHIESRSSARR----PGYEFMVECEHGAGDFG 286
LLFSP + +L+R + +F + + H+E+R + R P E+ V E GD
Sbjct: 84 LLFSPRAT-KPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLA 142
Query: 287 TALEELKKNVGYLNIISRNYKDNRSA-VPWFPRRIRDLDRFANQILSYGAELDSDHPGFT 463
L +++ +S + + VPWFPR++ +LD+ + + + +LD DHPGF+
Sbjct: 143 ALLSGVRQ-------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFS 195
Query: 464 DPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 196 DQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 227
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 61.3 bits (142), Expect = 2e-09
Identities = 24/40 (60%), Positives = 30/40 (75%)
Frame = +2
Query: 440 DSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D DHPGF+D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 40
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 61.3 bits (142), Expect = 2e-09
Identities = 24/40 (60%), Positives = 30/40 (75%)
Frame = +2
Query: 440 DSDHPGFTDPVYRARRKYFADIAYNYKHGQALPHVDYTKE 559
D DHPGF+D VYR RRK A+IA+ Y+HG +P V+YT E
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE 40
>X90568-1|CAA62188.1|26926|Homo sapiens titin protein.
Length = 26926
Score = 29.5 bits (63), Expect = 8.5
Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 4/29 (13%)
Frame = +2
Query: 56 PKLMEGG----NYIREGRDSTKSTWLLFS 130
P L++GG NY+ E RD+TK TW + S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
>AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein.
Length = 30000
Score = 29.5 bits (63), Expect = 8.5
Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 4/29 (13%)
Frame = +2
Query: 56 PKLMEGG----NYIREGRDSTKSTWLLFS 130
P L++GG NY+ E RD+TK TW + S
Sbjct: 28315 PPLIDGGSPIINYVIEKRDATKRTWSVVS 28343
>AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein.
Length = 26926
Score = 29.5 bits (63), Expect = 8.5
Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 4/29 (13%)
Frame = +2
Query: 56 PKLMEGG----NYIREGRDSTKSTWLLFS 130
P L++GG NY+ E RD+TK TW + S
Sbjct: 20891 PPLIDGGSPIINYVIEKRDATKRTWSVVS 20919
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 81,567,230
Number of Sequences: 237096
Number of extensions: 1689668
Number of successful extensions: 8200
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 8030
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8187
length of database: 76,859,062
effective HSP length: 86
effective length of database: 56,468,806
effective search space used: 5646880600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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