Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I09A02NGRL0004_F22
(652 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;... 268 8e-71
UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to Ecdysone-i... 210 2e-53
UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4; Cyanobact... 194 2e-48
UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate ... 185 7e-46
UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila melanogaster|... 183 4e-45
UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19; Magnol... 179 5e-44
UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14; Bacill... 173 3e-42
UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12; Bacteria... 171 9e-42
UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11; Clostrid... 171 1e-41
UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12; Firmic... 164 1e-39
UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17; Bacter... 163 3e-39
UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6; Bacteria|... 162 8e-39
UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to Ecdysone-i... 160 3e-38
UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2; ... 159 7e-38
UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140; Bacteri... 158 1e-37
UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;... 157 2e-37
UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4; Euteleost... 157 3e-37
UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9; Bacilli... 155 1e-36
UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibac... 152 6e-36
UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1; Corynebac... 152 6e-36
UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2; Desulfovi... 148 1e-34
UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1; Clostri... 147 2e-34
UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2; Bacteria|... 146 5e-34
UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia ... 144 1e-33
UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1; Staphyloc... 143 4e-33
UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate de... 141 1e-32
UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 140 3e-32
UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4; Thermotog... 139 6e-32
UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5; Bacillace... 138 1e-31
UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13; Firmic... 136 3e-31
UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3; Clostridi... 134 1e-30
UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant... 133 3e-30
UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;... 132 9e-30
UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant... 131 2e-29
UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 130 2e-29
UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3; Lactoco... 130 4e-29
UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4; Lactobaci... 129 7e-29
UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 128 1e-28
UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3; Fusobacte... 126 3e-28
UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6; Acti... 125 1e-27
UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8; Lactoba... 124 1e-27
UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1; ... 124 2e-27
UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;... 124 2e-27
UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula... 123 3e-27
UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1; Lactobaci... 122 6e-27
UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 122 6e-27
UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 122 7e-27
UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2; ... 120 2e-26
UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2; Propionib... 120 2e-26
UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate dehydrog... 119 5e-26
UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6; Mollicute... 119 7e-26
UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1; ... 118 9e-26
UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18; Bacter... 118 1e-25
UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizop... 117 3e-25
UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2; Euryarchaeot... 116 5e-25
UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 116 5e-25
UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3; Bifidob... 116 6e-25
UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4; Bacteria|... 114 1e-24
UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1; ... 114 2e-24
UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14; Thermoprote... 111 2e-23
UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep: Li... 109 6e-23
UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10; Campylob... 109 6e-23
UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomon... 109 6e-23
UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-... 109 7e-23
UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 108 1e-22
UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7; Bacteria|... 107 2e-22
UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2; Gammaproteo... 106 4e-22
UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 105 7e-22
UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|R... 105 1e-21
UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2; Pl... 104 2e-21
UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 103 3e-21
UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Re... 103 4e-21
UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4; Eutheria|... 103 5e-21
UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3; Methanomi... 102 6e-21
UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3; Acti... 101 1e-20
UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 101 1e-20
UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1; Bl... 101 1e-20
UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;... 101 1e-20
UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;... 101 1e-20
UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2; Phaeospha... 99 5e-20
UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28; Bacteroidet... 99 8e-20
UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1; Lac... 98 1e-19
UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1; Ce... 98 2e-19
UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1; Ther... 97 2e-19
UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7; Halobacteria... 97 2e-19
UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-... 97 3e-19
UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1; Lept... 97 3e-19
UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH - ... 95 2e-18
UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 95 2e-18
UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular org... 94 2e-18
UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3; Eimeriorina... 93 4e-18
UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2... 93 4e-18
UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 93 7e-18
UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 91 3e-17
UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:... 90 4e-17
UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17; Apicompl... 90 4e-17
UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5; Methanococcu... 90 5e-17
UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 89 6e-17
UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=... 89 9e-17
UniRef50_O26290 Cluster: Malate dehydrogenase; n=2; Methanobacte... 87 3e-16
UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococ... 87 5e-16
UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium ... 87 5e-16
UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=... 85 1e-15
UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 85 1e-15
UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobu... 85 1e-15
UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex ae... 85 1e-15
UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1; ... 85 2e-15
UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5; Gammaproteob... 83 6e-15
UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6; Plasmodi... 83 7e-15
UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene en... 83 7e-15
UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4; Thermoplasma... 82 1e-14
UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular or... 82 1e-14
UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular o... 80 5e-14
UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;... 79 7e-14
UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2; Meth... 79 7e-14
UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4; Pezizomyc... 78 2e-13
UniRef50_P11386 Cluster: Malate dehydrogenase; n=6; Sulfolobacea... 77 3e-13
UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4; Epsilonprote... 77 4e-13
UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|R... 77 5e-13
UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 77 5e-13
UniRef50_Q8Y860 Cluster: Lmo1057 protein; n=11; Listeria|Rep: Lm... 75 2e-12
UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-... 73 8e-12
UniRef50_Q8VMZ6 Cluster: L-lactate dehydrogenase; n=1; Listeria ... 70 4e-11
UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacte... 66 7e-10
UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter... 64 3e-09
UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1; St... 62 1e-08
UniRef50_Q59G78 Cluster: Lactate dehydrogenase B variant; n=1; H... 61 3e-08
UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1... 57 4e-07
UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1; Asp... 56 6e-07
UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4; Bacteroidale... 56 7e-07
UniRef50_Q1U8H4 Cluster: L-lactate dehydrogenase; n=2; Lactobaci... 53 7e-06
UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like prot... 53 7e-06
UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD bindi... 50 4e-05
UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12; Ca... 50 5e-05
UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacte... 49 1e-04
UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein OJA121... 45 0.002
UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 44 0.002
UniRef50_Q5NDY3 Cluster: Putative l-lactate dehydrogenase; n=1; ... 43 0.006
UniRef50_Q1WU75 Cluster: Lactate/malate dehydrogenase; n=1; Lact... 41 0.030
UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1; ... 41 0.030
UniRef50_Q03QL8 Cluster: Malate/lactate dehydrogenase; n=1; Lact... 39 0.12
UniRef50_Q039N1 Cluster: Malate/lactate dehydrogenase; n=1; Lact... 39 0.12
UniRef50_Q600I6 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 37 0.48
UniRef50_Q182W1 Cluster: Putative exported protein precursor; n=... 36 0.64
UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=... 35 1.5
UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5; Bacteroidale... 34 2.6
UniRef50_Q7SDH8 Cluster: Putative uncharacterized protein NCU026... 34 3.4
UniRef50_Q9ZIQ2 Cluster: RTX protein; n=9; Actinobacillus pleuro... 33 4.5
UniRef50_A1AP77 Cluster: Putative uncharacterized protein; n=3; ... 33 4.5
UniRef50_Q0E4Q4 Cluster: Os02g0105300 protein; n=1; Oryza sativa... 33 4.5
UniRef50_Q9N5K0 Cluster: Putative uncharacterized protein; n=1; ... 33 5.9
UniRef50_Q2JDG2 Cluster: Methyltransferase FkbM; n=3; Frankia|Re... 33 7.8
>UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;
Eukaryota|Rep: L-lactate dehydrogenase C chain - Homo
sapiens (Human)
Length = 332
Score = 268 bits (657), Expect = 8e-71
Identities = 123/190 (64%), Positives = 151/190 (79%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTY+ WKISGLP RVIGSG NLDSARFRYL+ E+LG+ TSCHG+IIGEHGDSSVP+
Sbjct: 141 DILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPL 200
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WSGVN+AGV L L+ K+GTDSD E+WK +H+ V++SAYE+IKLKGYTSWAIGLS+ LV
Sbjct: 201 WSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLV 260
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+IL N VH VST +KG +GI EE+FLS+PCVLG +GVSDV++ L E A +KSA
Sbjct: 261 GSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLNSEEEALFKKSA 320
Query: 542 TLMAKVQADI 571
+ +Q D+
Sbjct: 321 ETLWNIQKDL 330
>UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=2;
Apocrita|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 409
Score = 210 bits (513), Expect = 2e-53
Identities = 100/193 (51%), Positives = 137/193 (70%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DIL+++TWKISGLP RVIG+GT++DSARFR+L+++RLGIA +S H IIGEHGDS VP+
Sbjct: 217 DILSWLTWKISGLPASRVIGTGTHVDSARFRFLIADRLGIAPSSVHATIIGEHGDSQVPL 276
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WSGVN+AGV+ D+ IG ++D E W EL + VV+ V LKGYT+ IGL+ + +V
Sbjct: 277 WSGVNVAGVQFRDILPNIGLETDEERWYELSKEVVRLGPTVRCLKGYTNTTIGLATADIV 336
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAIL N V VST ++G H + E+FLSLPC +G G++++IR +TE E + SA
Sbjct: 337 RAILNNTQRVMPVSTLIQGHHEVCHEMFLSLPCSIGEQGITNIIRMRITEYEKKLFQTSA 396
Query: 542 TLMAKVQADIKVL 580
++ VQ IK +
Sbjct: 397 NVVFNVQKGIKAV 409
>UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4;
Cyanobacteria|Rep: L-lactate dehydrogenase - Gloeobacter
violaceus
Length = 330
Score = 194 bits (473), Expect = 2e-48
Identities = 97/183 (53%), Positives = 125/183 (68%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TYV K++GLP RVIGSGT LD+ARFRYLL+ERL + S H YIIGEHGDS VPV
Sbjct: 140 DVMTYVAMKLAGLPPSRVIGSGTVLDTARFRYLLAERLRVDPRSLHAYIIGEHGDSEVPV 199
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS N+AG LS++ +GT DP E+ E V +AYE+I+ KG TSWAIGL+ +Q+V
Sbjct: 200 WSRANVAGAFLSEIEPAVGTPDDPAKMFEVFEHVKNAAYEIIERKGATSWAIGLATTQIV 259
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAI N N V VS + G HGI EEV L+ P VL G+ +++ L+ E QL++SA
Sbjct: 260 RAITRNQNRVLPVSVLMSGLHGI-EEVCLAYPAVLNRQGIDRLVKFSLSPGEEEQLQRSA 318
Query: 542 TLM 550
+M
Sbjct: 319 RVM 321
>UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate
dehydrogenase A chain (LDH-A) (LDH muscle subunit)
(LDH-M); n=2; Apis mellifera|Rep: PREDICTED: similar to
L-lactate dehydrogenase A chain (LDH-A) (LDH muscle
subunit) (LDH-M) - Apis mellifera
Length = 348
Score = 185 bits (451), Expect = 7e-46
Identities = 82/191 (42%), Positives = 125/191 (65%), Gaps = 1/191 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DIL+Y K+SG P HRV+G GT LDS RF+Y ++++LGI+ +S +I E+G +SVP+
Sbjct: 153 DILSYAAMKLSGFPPHRVVGLGTFLDSCRFQYFIAQKLGISASSVQASVICENGPTSVPI 212
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G++L D+NK IGT +DPE+W ELH V+ ++I KGY W +G+ +++V
Sbjct: 213 WSAVTVMGIKLKDINKDIGTKADPESWGELHAKVIDCDNDLISRKGYRCWGMGICAAEVV 272
Query: 362 RAILYNANSVHAVSTYLKG-EHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AI+ N VSTYLKG HG++++V++SLPC++G +G+ ++R P T E S
Sbjct: 273 DAIVRNTCICVTVSTYLKGCRHGLEKDVYMSLPCIVGRNGIETLLRHPYTPEEQELTETS 332
Query: 539 ATLMAKVQADI 571
+ + Q I
Sbjct: 333 CRTIFETQKSI 343
>UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila
melanogaster|Rep: AT22132p - Drosophila melanogaster
(Fruit fly)
Length = 361
Score = 183 bits (445), Expect = 4e-45
Identities = 81/192 (42%), Positives = 123/192 (64%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TY +I+ LPKHR +G +LD+ RFR L++ RL + + HGY+IGEHG S+VPV
Sbjct: 170 DVMTYAVQRITNLPKHRCFTTGCHLDTVRFRNLIANRLRLPPSQVHGYVIGEHGASAVPV 229
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V+IAG+RL+D+ K + DPENW ++++ V V K KGYT+WAI L+ + +V
Sbjct: 230 WSSVSIAGIRLNDVVKNLACGDDPENWAKINKQVTTGGLAVAKTKGYTNWAIALTCADIV 289
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+A+ + V T +KG GI + V LSLPC++ G+S V PLT+ E ++L SA
Sbjct: 290 QAMSGGKGKIACVGTDMKGLSGIQDNVVLSLPCLVTAGGISHVFELPLTDVEQSKLLASA 349
Query: 542 TLMAKVQADIKV 577
++ + Q + +
Sbjct: 350 NILLEAQCSLSI 361
>UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19;
Magnoliophyta|Rep: L-lactate dehydrogenase A - Hordeum
vulgare (Barley)
Length = 356
Score = 179 bits (436), Expect = 5e-44
Identities = 89/182 (48%), Positives = 114/182 (62%), Gaps = 2/182 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTYV WK+SG P RVIGSGTNLDS+RFR+L++E L + Y++GEHGDSSV +
Sbjct: 163 DVLTYVAWKLSGFPASRVIGSGTNLDSSRFRFLIAEHLDVNAQDVQAYMVGEHGDSSVAI 222
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS +++ G+ + D + + VV AYEVI LKGYTSWAIG S++ L
Sbjct: 223 WSSISVGGMPAFKSLRDSHRSFDEAALEGIRRAVVGGAYEVIGLKGYTSWAIGYSVASLA 282
Query: 362 RAILYNANSVHAVSTYLKGEHGIDE--EVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
++L + VH VS G HGI + EVFLSLP LG G+ V LTE E AQLR+
Sbjct: 283 ASLLRDQRRVHPVSVLASGFHGISDGHEVFLSLPARLGRGGILGVAEMDLTEAEAAQLRR 342
Query: 536 SA 541
SA
Sbjct: 343 SA 344
>UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14;
Bacillales|Rep: L-lactate dehydrogenase X - Bacillus
psychrosaccharolyticus
Length = 319
Score = 173 bits (421), Expect = 3e-42
Identities = 85/186 (45%), Positives = 124/186 (66%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTY TWK SGLPK RVIGSGT LDS RFR+LL E IA + H +IIGEHGD+ +PV
Sbjct: 127 DILTYATWKFSGLPKERVIGSGTILDSGRFRFLLGEYFDIAPANVHAHIIGEHGDTELPV 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS +I GV + +L + + E+ +L V +AY +IK KG T + I + L+++
Sbjct: 187 WSHADIGGVPVEELITR-NPEYKMEDLDQLFVNVRDAAYHIIKKKGATYYGIAMGLARIT 245
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AIL N NSV VSTYL GE+G +++V++ +P V+ +G+ +++ L+ETE Q S+
Sbjct: 246 KAILNNENSVLTVSTYLDGEYG-EKDVYIGVPAVVNRTGIREILELTLSETEQKQFTHSS 304
Query: 542 TLMAKV 559
T++ ++
Sbjct: 305 TVLKEI 310
>UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12;
Bacteria|Rep: L-lactate dehydrogenase - Clostridium
tetani
Length = 316
Score = 171 bits (417), Expect = 9e-42
Identities = 83/183 (45%), Positives = 125/183 (68%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTYVT+K+SG P+ RVIGSGT LD++RFRYLL E I + H YI+GEHGDS +
Sbjct: 125 DILTYVTYKLSGFPQERVIGSGTVLDTSRFRYLLGEHFKIDVRNVHTYILGEHGDSEIAA 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS NIAG+ + D K I + + E V +AYEV++ KGYTS+AI L++ ++V
Sbjct: 185 WSLTNIAGISVEDYCKDICKGCEGNFKNRIPEEVKNAAYEVLERKGYTSYAIALAVRRIV 244
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AI+ + +S+ VST L+GE+GI+ ++++ +P V+G +G+ V+ L++ E QL++SA
Sbjct: 245 EAIIRDEDSILTVSTLLRGEYGIN-DIYMGIPSVIGETGIKRVLEVKLSKDEEKQLKESA 303
Query: 542 TLM 550
++
Sbjct: 304 EVL 306
>UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
perfringens
Length = 317
Score = 171 bits (416), Expect = 1e-41
Identities = 81/183 (44%), Positives = 122/183 (66%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTY+T+K+SG PK RVIGSGT LD++R +Y+LSE I + H YIIGEHGDS +
Sbjct: 126 DILTYITYKLSGFPKERVIGSGTVLDTSRLKYMLSEHFDIDARNVHTYIIGEHGDSEITA 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS NIAG + + K + + D KEL E V +AYE+I KGYT++A+ L+++++V
Sbjct: 186 WSLTNIAGANVEEYCKTVCANCDGSFKKELPEKVKNAAYEIINSKGYTNYAVALAVTRIV 245
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AIL + N++ VS+ +G++GID V+L++P ++ SG ++ P++ E L KSA
Sbjct: 246 EAILRDENAILTVSSLFEGQYGID-NVYLAMPTIVDRSGARQILDVPISNEEKENLIKSA 304
Query: 542 TLM 550
++
Sbjct: 305 EIL 307
>UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12;
Firmicutes|Rep: L-lactate dehydrogenase 2 - Bacillus
anthracis
Length = 314
Score = 164 bits (399), Expect = 1e-39
Identities = 82/190 (43%), Positives = 120/190 (63%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTYVTWK SGLPK RVIGSGT LDSARFRY+L + L + + H YI+GEHGD+ +PV
Sbjct: 126 DILTYVTWKESGLPKERVIGSGTTLDSARFRYMLGDYLDVDPRNVHAYIVGEHGDTELPV 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS I GV+ + E+ ++ E V +AY +I+ KG T + IG+SL ++
Sbjct: 186 WSHATI-GVQKLETILANNEQYKQEDLDKIFENVRDAAYHIIERKGATYYGIGMSLLRVT 244
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AIL N NSV VS YL+G++G +++ ++ +P V+ GV +++ L E E A+ S
Sbjct: 245 KAILNNENSVLTVSAYLEGQYG-EKDAYVGVPAVINREGVREIVELELNEEEKAKFAHSV 303
Query: 542 TLMAKVQADI 571
++ + A +
Sbjct: 304 KVLKETMAPV 313
>UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17;
Bacteria|Rep: L-lactate dehydrogenase 2 -
Bifidobacterium longum
Length = 320
Score = 163 bits (396), Expect = 3e-39
Identities = 77/189 (40%), Positives = 124/189 (65%), Gaps = 1/189 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI T+V K++GLP++++ GSGTNLDSAR R+L++++ G+ + H YI GEHGDS VP+
Sbjct: 129 DIATHVAQKLTGLPENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGDSEVPL 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDS-DPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
W I GV + D G D D + +E+H+ V +AY++I KG T++AIG+S +
Sbjct: 189 WESATIGGVPMCDWTPLPGHDPLDADKREEIHQEVKNAAYKIINGKGATNYAIGMSGVDI 248
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+ A+L++ N + VS+ LK HGI ++ +S+P +L GV++ I P+++ ELA L++S
Sbjct: 249 IEAVLHDTNRILPVSSMLKDFHGI-SDICMSVPTLLNRQGVNNTINTPVSDKELAALKRS 307
Query: 539 ATLMAKVQA 565
A + + A
Sbjct: 308 AETLKETAA 316
>UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6;
Bacteria|Rep: L-lactate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 321
Score = 162 bits (393), Expect = 8e-39
Identities = 79/183 (43%), Positives = 121/183 (66%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI++Y ++KISGLP HRV+GSGT LD+ARFRYLL + + S HG I+GEHGD+ VP+
Sbjct: 130 DIISYASYKISGLPAHRVLGSGTILDTARFRYLLGQHFSVDARSVHGLILGEHGDTEVPI 189
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS NIAG+RL + + D + + +AY++I+ KG T +A+ + L Q+V
Sbjct: 190 WSLANIAGIRLREYCRLHSLPYDEHVFDTIFTDTRDAAYKIIERKGATYYAVAVGLMQIV 249
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+I+ + +V ST ++G +GI+ +V+LSLP ++G GV V+ L+E ELA+L+ SA
Sbjct: 250 ESIVRDQKTVLTTSTLVEGAYGIN-DVYLSLPTIVGAKGVVQVLTPDLSEEELAKLQHSA 308
Query: 542 TLM 550
++
Sbjct: 309 EVL 311
>UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=1; Apis
mellifera|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 368
Score = 160 bits (388), Expect = 3e-38
Identities = 73/194 (37%), Positives = 118/194 (60%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+++Y+ WK+SG P +RV+G GT +D AR + +S RL +A +S IG GD +VP+
Sbjct: 166 DVMSYIAWKLSGFPSNRVLGIGTLIDCARLQDFVSRRLNVARSSVSCMTIGSQGDMAVPL 225
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS +++ G++L D+N +IG DPE W E+ E V E+ + KG W + +S +++V
Sbjct: 226 WSSISVGGMKLRDINSRIGEQDDPEKWYEIEENVKSVGKELEEKKGSCCWGVAISTTEIV 285
Query: 362 RAILYNANSVHAVSTY-LKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AI+ N V ST+ L HG D++V++S+PCV+G GV +RQ L+E E A ++
Sbjct: 286 DAIVRNTKVVLPASTHILSCAHGTDKDVYMSVPCVIGREGVYCTVRQKLSEQEKAAVQTC 345
Query: 539 ATLMAKVQADIKVL 580
A + + + +L
Sbjct: 346 ADNIRNILRESGIL 359
>UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2;
Ruminococcus|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 316
Score = 159 bits (385), Expect = 7e-38
Identities = 77/192 (40%), Positives = 124/192 (64%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILT V + SG PK RVIGSGT LD+AR +Y++SE+L + + + H +I+GEHGDS +
Sbjct: 124 DILTEVALRESGFPKERVIGSGTVLDTARLKYIISEKLDVDSRNVHAFIVGEHGDSELAA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS NI G++L D K G + ++ +E+++ V SAYE+I+ KG T + IG++ ++V
Sbjct: 184 WSCANIYGIKLQDFAKMRGYEHFAQDMEEVYKGVRDSAYEIIERKGATYYGIGMAAEKIV 243
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AI+ N+++V +S L G++G+ E + LS+P ++G G V+ +E E+ +LRKSA
Sbjct: 244 EAIVRNSHTVAPISVSLDGKYGL-EGLCLSIPTIVGRGGAEQVLEIDFSEEEMKKLRKSA 302
Query: 542 TLMAKVQADIKV 577
+ V + +
Sbjct: 303 EELGAVLDQVNI 314
>UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140;
Bacteria|Rep: L-lactate dehydrogenase - Streptococcus
pneumoniae
Length = 328
Score = 158 bits (383), Expect = 1e-37
Identities = 81/180 (45%), Positives = 114/180 (63%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTY TWK SG PK RVIGSGT+LDSARFR L+E+L + S H YI+GEHGDS V
Sbjct: 129 DVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAV 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS NIAGV L + K + E EL E V +AY +I KG T + I ++L+++
Sbjct: 189 WSHANIAGVNLEEFLKDTQNVQEAE-LIELFEGVRDAAYTIINKKGATYYGIAVALARIT 247
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AIL + N+V +S + +G++G+ E VF+ P V+G G+ + PL + E +++ SA
Sbjct: 248 KAILDDENAVLPLSVFQEGQYGV-ENVFIGQPAVVGAHGIVRPVNIPLNDAETQKMQASA 306
>UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;
Clostridium|Rep: L-lactate dehydrogenase precursor -
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Length = 318
Score = 157 bits (382), Expect = 2e-37
Identities = 84/193 (43%), Positives = 122/193 (63%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+TY+ K SGLP +VIGSGT LDS RFRYLLSE+LG+ + HGYIIGEHGDS +P+
Sbjct: 127 DIITYMIQKWSGLPVGKVIGSGTVLDSIRFRYLLSEKLGVDVKNVHGYIIGEHGDSQLPL 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS +IAG +++ + E+ K++ E V + +IK KG T + I +S++ +V
Sbjct: 187 WSCTHIAGKNINEYIDDPKCNFTEEDKKKIAEDVKTAGATIIKNKGATYYGIAVSINTIV 246
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+L N N++ V T + G +GI E+V +SLP ++ GV +V++ LT E LR SA
Sbjct: 247 ETLLKNQNTIRTVGTVINGMYGI-EDVAISLPSIVNSEGVQEVLQFNLTPEEEEALRFSA 305
Query: 542 TLMAKVQADIKVL 580
+ KV ++K L
Sbjct: 306 EQVKKVLNEVKNL 318
>UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4;
Euteleostomi|Rep: L-lactate dehydrogenase - Tetraodon
nigroviridis (Green puffer)
Length = 360
Score = 157 bits (380), Expect = 3e-37
Identities = 68/97 (70%), Positives = 81/97 (83%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTYVTWK+SGLPKHRVIGSGTNLDSARFRYL++ERLGI +S +G+++GEHGD+SVPV
Sbjct: 142 DVLTYVTWKLSGLPKHRVIGSGTNLDSARFRYLMAERLGIHASSFNGWVLGEHGDTSVPV 201
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKS 292
WSG N+AGV L LN IGTD D E W+ H+ VV S
Sbjct: 202 WSGANVAGVNLQKLNPDIGTDDDKEEWRATHKAVVDS 238
>UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9;
Bacilli|Rep: L-lactate dehydrogenase 2 - Enterococcus
faecalis (Streptococcus faecalis)
Length = 317
Score = 155 bits (375), Expect = 1e-36
Identities = 82/194 (42%), Positives = 120/194 (61%), Gaps = 3/194 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTYV W+ SGLP RVIG+GT LD+ RFR LS+RL I + HGYIIGEHGDS V V
Sbjct: 126 DVLTYVAWQASGLPVSRVIGTGTTLDTTRFRKELSQRLAIDPRNVHGYIIGEHGDSEVAV 185
Query: 182 WSGVNIAG---VRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLS 352
WS I + + D +++ +D P + + V +AYE+I K T + IG+S +
Sbjct: 186 WSHTMIGTKPILEIVDTTERLTSDDLP----IISDKVKNTAYEIIDRKQATYYGIGMSTA 241
Query: 353 QLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLR 532
++V+AIL N ++ VS YL G++G ++VF +P V+G+ GV+D+I L E +
Sbjct: 242 RIVKAILNNEQAILPVSAYLDGQYG-QQDVFTGIPAVVGNQGVTDIIELNLNAAEKELFQ 300
Query: 533 KSATLMAKVQADIK 574
KS T + +V A ++
Sbjct: 301 KSVTQLKQVMASLQ 314
>UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibacter
ruber DSM 13855|Rep: L-lactate dehydrogenase -
Salinibacter ruber (strain DSM 13855)
Length = 316
Score = 152 bits (369), Expect = 6e-36
Identities = 78/192 (40%), Positives = 117/192 (60%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTY+ ++S P R++G+GT LD+ARFR LL G+ S H YI+GEHGDS VP+
Sbjct: 125 DVLTYICQELSSRPNRRILGTGTLLDTARFRALLGRHYGVDPRSVHAYILGEHGDSEVPI 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS I G ++ +G + + E + + E +AYE+I KG+T AIGL ++++V
Sbjct: 185 WSNATIGGQKIRG-ETVLGKEWEEEAMQSIFEQARDAAYEIIDRKGHTDTAIGLVIARIV 243
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RA+L + +V VST G +GID +V LS+PCV+G G+ + L++ E LR SA
Sbjct: 244 RAVLEDQQNVLPVSTRPDGAYGID-DVCLSVPCVVGLEGMEKRVDPGLSDEEREALRDSA 302
Query: 542 TLMAKVQADIKV 577
+ +AD+ V
Sbjct: 303 RALRDSRADLTV 314
>UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1;
Corynebacterium jeikeium K411|Rep: L-lactate
dehydrogenase - Corynebacterium jeikeium (strain K411)
Length = 326
Score = 152 bits (369), Expect = 6e-36
Identities = 76/189 (40%), Positives = 114/189 (60%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DIL+Y TWK SG+ RVIGSGT LD+ARFRY L +A TS H Y+IGEHGD+ +PV
Sbjct: 136 DILSYATWKFSGMDSSRVIGSGTILDTARFRYALGRYFDLAPTSVHAYVIGEHGDTELPV 195
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
S ++AG + + IG +D E+ E+ +AYE+I+ KG TS+ IG+ L+++
Sbjct: 196 LSAGSVAGTSIHHRLEMIGESAD-EDVDEIFVKTRDAAYEIIQAKGSTSFGIGMGLARIT 254
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+A+ N + V +ST L+GE+G E++++ P V+ GV + L E + SA
Sbjct: 255 QAVFSNQDVVLPISTLLQGEYGF-EDIYIGTPAVINRQGVRHAVELQLDSEEKERFDHSA 313
Query: 542 TLMAKVQAD 568
++ KV +
Sbjct: 314 NVLRKVMGE 322
>UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2;
Desulfovibrio vulgaris subsp. vulgaris|Rep: L-lactate
dehydrogenase - Desulfovibrio vulgaris (strain
Hildenborough / ATCC 29579 / NCIMB8303)
Length = 309
Score = 148 bits (358), Expect = 1e-34
Identities = 76/185 (41%), Positives = 118/185 (63%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT+V ++G+ RVIGSGT LDSARFR ++E LG+ H +I+GEHGDS V +
Sbjct: 121 DVLTHVARTVTGVAPGRVIGSGTVLDSARFRGHVAEILGVDVRGVHAHIVGEHGDSEVAL 180
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS N++G+ ++++ + G D ++ V +AYE+I KG T + IG+SL ++V
Sbjct: 181 WSRANVSGIPVAEMCARRGIAYDAAFREKALGHVRHAAYEIIGRKGATGYGIGMSLCRIV 240
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AIL++ +SV VS + G +G+ +V LSLPCV+G G+ +V+ P+ E E A L SA
Sbjct: 241 EAILHDEHSVLTVSCPVAGHYGLG-DVSLSLPCVIGSDGIEEVLDAPIAEDEQAALAASA 299
Query: 542 TLMAK 556
++ +
Sbjct: 300 RVLGE 304
>UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1;
Clostridium acetobutylicum|Rep: L-lactate dehydrogenase
2 - Clostridium acetobutylicum
Length = 320
Score = 147 bits (356), Expect = 2e-34
Identities = 76/180 (42%), Positives = 117/180 (65%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI TY PK+++IG+GT LD+AR R ++ ++ + + + HGY++GEHG SS
Sbjct: 129 DIATYYCQNNFDYPKNKIIGTGTLLDTARMRKIIGKKYNVDSKNVHGYVLGEHGGSSFTS 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS VNIAG+ + LN I D + E+ + V S EV+KLKGYTS I +S+S+LV
Sbjct: 189 WSDVNIAGIPFNQLN-DIFKDHYKVDKDEVDKEVRDSGIEVLKLKGYTSAGIAMSVSRLV 247
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+A+L N S+ VS+ L+GE+GI+ +V LS+PC++ +G+ + PL++ E+ +L KSA
Sbjct: 248 KAMLLNEQSILPVSSTLEGEYGIN-DVALSIPCIITSNGIEKKLEIPLSKDEVEKLNKSA 306
>UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2;
Bacteria|Rep: L-lactate dehydrogenase - Treponema
denticola
Length = 315
Score = 146 bits (353), Expect = 5e-34
Identities = 82/181 (45%), Positives = 110/181 (60%), Gaps = 1/181 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILT K SG + RVIGSGT LD+ARFRY LS+ G+ + HGYI+GEHGDS
Sbjct: 125 DILTRAALKASGWERGRVIGSGTVLDTARFRYTLSKECGVDARNIHGYILGEHGDSEFAA 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWK-ELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS ++AG R+ + S P K ++ E V SAY +I KG T +A+GL+L+++
Sbjct: 185 WSMTSVAGRRIDEYCSGGVCSSGPHFDKAKILEEVRNSAYHIIDYKGSTYFAVGLALTRI 244
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AIL N +S+ +VS L GE G+ ++V LS+PC++G SG VI L E A L S
Sbjct: 245 AGAILRNEHSILSVSMTLDGEFGL-KDVCLSVPCIVGRSGAERVIESDLPADEQAALEAS 303
Query: 539 A 541
A
Sbjct: 304 A 304
>UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia
burgdorferi group|Rep: L-lactate dehydrogenase -
Borrelia burgdorferi (Lyme disease spirochete)
Length = 316
Score = 144 bits (350), Expect = 1e-33
Identities = 74/181 (40%), Positives = 114/181 (62%), Gaps = 1/181 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+TYVT K S P H+VIG+GT LD++R RY LS+ + T + H YI+GEHGDSS
Sbjct: 126 DIMTYVTMKYSKFPIHKVIGTGTILDTSRLRYFLSDHFNVNTQNIHSYIMGEHGDSSFAT 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
W IA LS+ + G ++ E E+H+ VV +AYEVIKLKG T +AIGL + +V
Sbjct: 186 WDETKIAMKPLSEYLAE-GKITELE-LDEIHKKVVNAAYEVIKLKGATYYAIGLGIKNIV 243
Query: 362 RAILYNANSVHAVSTYLKGEH-GIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AI+ + N + +S+Y+ G++ G+ +++++ P ++ GV +V+ ++ EL + S
Sbjct: 244 NAIIGDQNVILPISSYINGQYGGLIKDIYIGAPAIVCKEGVKEVLNFKISPKELDKFNSS 303
Query: 539 A 541
A
Sbjct: 304 A 304
>UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1;
Staphylococcus haemolyticus JCSC1435|Rep: L-lactate
dehydrogenase - Staphylococcus haemolyticus (strain
JCSC1435)
Length = 318
Score = 143 bits (346), Expect = 4e-33
Identities = 73/195 (37%), Positives = 121/195 (62%), Gaps = 1/195 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI++YV ++S PK+++IGSGT+LD+ARF++ LS +A + IIGEHGDS V V
Sbjct: 124 DIMSYVVKRVSNFPKNKIIGSGTSLDTARFQFFLSREFDVAPNQVYAPIIGEHGDSQVAV 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWK-ELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS IAG + DL + ++++ E +K + + Y++ KG T++ I LSL ++
Sbjct: 184 WSHAQIAGEPVLDL---LPSNTNLEAFKTSISNRTTQIGYDIYVRKGTTNFGISLSLVRI 240
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
V AIL+N N + VS+Y++GE+G+ +V++ +P V+ +G +I L++ EL+QL S
Sbjct: 241 VEAILFNKNIIMNVSSYVEGEYGL-SDVYIGVPTVINRNGADRIIELALSKEELSQLHHS 299
Query: 539 ATLMAKVQADIKVLI 583
A ++ Q +I
Sbjct: 300 ADIILDYQRQADAII 314
>UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate
dehydrogenase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to lactate dehydrogenase - Nasonia vitripennis
Length = 352
Score = 141 bits (342), Expect = 1e-32
Identities = 72/192 (37%), Positives = 113/192 (58%), Gaps = 2/192 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+L+++ K+SG P RV+G GT LD+ R ++ L++ LG+ + H +I E G +SVP+
Sbjct: 158 DVLSHLAMKLSGFPSQRVLGLGTLLDNCRLQHELAKELGVNQAAVHSMVIAESGPTSVPI 217
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENW-KELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS ++ G++L D++K IG DPE + LH VV E+I+ KG WA L ++
Sbjct: 218 WSAASVMGMKLKDIDKDIG---DPEGFAAALHAKVVNCNRELIRRKGQHCWAAALCTCEI 274
Query: 359 VRAILYNANSVHAVSTYLKG-EHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+ AI+ N + VST++KG HG++++VF SLPCVLG GV +R T E +
Sbjct: 275 IDAIVRNTCACLTVSTFVKGCRHGLEKDVFASLPCVLGRGGVLAYMRHLYTPEEQELTSR 334
Query: 536 SATLMAKVQADI 571
S + + Q +
Sbjct: 335 SCRRIYEAQKSV 346
>UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
mobile|Rep: L-lactate dehydrogenase - Mycoplasma mobile
Length = 318
Score = 140 bits (339), Expect = 3e-32
Identities = 68/183 (37%), Positives = 119/183 (65%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T++ +G K+RVI SGT+LDSAR R+ +S++L + S +++GEHGDSSV V
Sbjct: 126 DVMTFIYQHETGFDKNRVISSGTSLDSARLRFEISKKLKVHPKSVQAFVLGEHGDSSVSV 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S ++G +++ K+ G + +++H V K AYE+I KG T + IG ++++LV
Sbjct: 186 YSAATVSGKSFNEIVKERGISK--KELEDMHTTVYKKAYEIINRKGSTYFGIGSTVAELV 243
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AIL +++++ V YL G++G+ +++++ +P VLG GV +VI LT+ E + SA
Sbjct: 244 EAILTDSHAIFGVGVYLTGQYGV-KDLYIGVPTVLGSKGVVEVINFNLTKEEQEKFVSSA 302
Query: 542 TLM 550
T++
Sbjct: 303 TIL 305
>UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4;
Thermotogaceae|Rep: L-lactate dehydrogenase - Thermotoga
maritima
Length = 319
Score = 139 bits (336), Expect = 6e-32
Identities = 72/183 (39%), Positives = 112/183 (61%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTY K SG+ +V GSGT LD+AR R L+++ G + S H Y+IGEHGDS VPV
Sbjct: 120 DVLTYFFLKESGMDPRKVFGSGTVLDTARLRTLIAQHCGFSPRSVHVYVIGEHGDSEVPV 179
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WSG I G+ L ++ +I D + + E ++AYE+I+ KG T +AI L+++ +V
Sbjct: 180 WSGAMIGGIPLQNM-CQICQKCDSKILENFAEKTKRAAYEIIERKGATHYAIALAVADIV 238
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+I ++ V +S YL+ G+ +++ +S+P LG GV ++ L E EL RKSA
Sbjct: 239 ESIFFDEKRVLTLSVYLEDYLGV-KDLCISVPVTLGKHGVERILELNLNEEELEAFRKSA 297
Query: 542 TLM 550
+++
Sbjct: 298 SIL 300
>UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5;
Bacillaceae|Rep: L-lactate dehydrogenase -
Oceanobacillus iheyensis
Length = 321
Score = 138 bits (333), Expect = 1e-31
Identities = 73/180 (40%), Positives = 108/180 (60%), Gaps = 1/180 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILT SGLP HRVIGSGT LD+AR RY L E ++ + H YIIGEHGD+ +P+
Sbjct: 129 DILTQAVISFSGLPPHRVIGSGTTLDTARLRYELGEYFHLSPKNIHAYIIGEHGDTELPL 188
Query: 182 WSGVNIAGV-RLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS I V L+ LN+ E+ ++ V +AY +I+ KG T + I +SL ++
Sbjct: 189 WSTATIGTVPLLTYLNR--SESYTTEDLDDIFTNVRDAAYRIIQKKGATYYGIAMSLVRV 246
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AIL + +S+ S++L+GE+G+D V + +P ++ +GVS++I P+ E E Q S
Sbjct: 247 TEAILKDEHSILTTSSFLQGEYGVD-NVCIGVPTIINRNGVSEIIEVPMNEDEQKQFNHS 305
>UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13;
Firmicutes|Rep: L-lactate dehydrogenase 3 - Bacillus
anthracis
Length = 316
Score = 136 bits (330), Expect = 3e-31
Identities = 68/183 (37%), Positives = 110/183 (60%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+TY WK+SGLP++RVIG+GT+LDS+R R +LSE L + S HGY +GEHGDS +
Sbjct: 126 DIITYQVWKLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVA 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G + + ++ + E+ E K+ +E+ K KG T + IG SL+ +
Sbjct: 186 WSHVTVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGWEIYKRKGTTYYGIGNSLAYIA 245
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+I + + V AVS L GE+G + ++ +P ++ G+ +++ LTE E ++ KS
Sbjct: 246 SSIFNDDHRVIAVSAILDGEYG-EYDICTGVPAIITRDGIREIVELNLTEDEESRFAKSN 304
Query: 542 TLM 550
++
Sbjct: 305 DIL 307
>UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
difficile (strain 630)
Length = 322
Score = 134 bits (325), Expect = 1e-30
Identities = 73/193 (37%), Positives = 110/193 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T W+ SG PK++VIG+GT LDS R R +LSE GIA S Y +GEHGDS +
Sbjct: 131 DVVTNYIWEKSGFPKNKVIGTGTALDSTRLRRILSEETGIAQQSIQAYSMGEHGDSQMVP 190
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V+I G + D+ K + + + E K+ +I K T + IG +L ++V
Sbjct: 191 WSHVSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKKTGISIINGKDCTEFGIGTALVEIV 250
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AIL+N V VST L+G++ + VF +PCV+G G+ +I +TE E + KS
Sbjct: 251 KAILHNEKKVLPVSTLLEGQYN-ERNVFAGVPCVIGKDGIEQIIEINMTEYEQNEFNKSC 309
Query: 542 TLMAKVQADIKVL 580
+++ + A K L
Sbjct: 310 SVLREYIALSKTL 322
>UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=23; Tetrapoda|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Mus musculus (Mouse)
Length = 471
Score = 133 bits (322), Expect = 3e-30
Identities = 77/193 (39%), Positives = 117/193 (60%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
+I++YVTWK+S P RV+G G NLDS R +Y+++ L + T+ +++GE G++ V
Sbjct: 297 EIMSYVTWKLSTFPATRVVGIGCNLDSQRLQYIITSVLKVQTSGKEVWVVGEQGENKVCS 356
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WSG + GV LS P + +L A E++K+KG SW++GLS++ LV
Sbjct: 357 WSGRD--GV-LS-----------PSSQAQLSSR----AMELLKVKGQRSWSVGLSVADLV 398
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTE-TELAQLRKS 538
I+ N VH+VST KG +G+D EVFLSLPC+LG GVS+VI+ E T L+ S
Sbjct: 399 DTIINNKRKVHSVSTLAKGYYGLDNEVFLSLPCILGTGGVSEVIKTKAGEDTVTGTLQAS 458
Query: 539 ATLMAKVQADIKV 577
A+ + +Q +++
Sbjct: 459 ASSIHALQQQLEL 471
>UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;
Clostridium phytofermentans ISDg|Rep: L-lactate
dehydrogenase precursor - Clostridium phytofermentans
ISDg
Length = 325
Score = 132 bits (318), Expect = 9e-30
Identities = 65/191 (34%), Positives = 114/191 (59%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + +++SGLPK +V+G+GT +DSAR ++ + + L + S Y +GEHGDS +
Sbjct: 128 DSIAQYVYQLSGLPKQQVLGTGTAIDSARLKHFIGDILHVDPRSIQAYTMGEHGDSQMCP 187
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G + D+ + SD + + E+ V + ++++ +KG T + I + ++
Sbjct: 188 WSLVTVGGKNIMDIVRDNKEYSDID-FNEILYKVTRVGFDILSVKGTTCYGIASAAVGII 246
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AILY+ NS+ VST L+GE+G + +V+ +PC+L GV DV+ +TE EL Q R S
Sbjct: 247 KAILYDENSILPVSTLLEGEYG-EFDVYAGVPCILNRFGVKDVVEVNMTEVELNQFRASV 305
Query: 542 TLMAKVQADIK 574
++ + ++K
Sbjct: 306 HVVREAIENLK 316
>UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=15; Euteleostomi|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Homo sapiens (Human)
Length = 471
Score = 131 bits (316), Expect = 2e-29
Identities = 73/193 (37%), Positives = 112/193 (58%), Gaps = 1/193 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
+I+TYVTWK+S P +RVIG G NLDS R +Y+++ L T+ ++IGE G+ V
Sbjct: 297 EIMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLT 356
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WSG S + + A E++++KG SW++GLS++ +V
Sbjct: 357 WSGQEEVVSHTSQVQ------------------LSNRAMELLRVKGQRSWSVGLSVADMV 398
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTE-TELAQLRKS 538
+I+ N VH+VS KG + I+ EVFLSLPC+LG +GVS+VI+ L E T +L+ S
Sbjct: 399 DSIVNNKKKVHSVSALAKGYYDINSEVFLSLPCILGTNGVSEVIKTTLKEDTVTEKLQSS 458
Query: 539 ATLMAKVQADIKV 577
A+ + +Q +K+
Sbjct: 459 ASSIHSLQQQLKL 471
>UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
beijerinckii NCIMB 8052|Rep: L-lactate dehydrogenase -
Clostridium beijerinckii NCIMB 8052
Length = 316
Score = 130 bits (315), Expect = 2e-29
Identities = 65/192 (33%), Positives = 109/192 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+++Y K+SGLP +VIG+GT LDSAR +Y L++ + + S H +GEHGDS +
Sbjct: 126 DVMSYYVHKLSGLPASKVIGTGTALDSARLKYHLADVMSVDPQSVHALCMGEHGDSQIIP 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS + + G + D+ N + E + K AY ++ KG T++ I + Q+V
Sbjct: 186 WSQITVGGKKFLDIINDNKMRLKGFNLNSVTEDIKKIAYRIVNAKGATTFGIAATTVQIV 245
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AIL + N V VS L GE+G + + + +P VL + GV +++ L E+E A+L++S
Sbjct: 246 KAILRDENKVIPVSAMLNGEYG-ESDTYAGVPAVLNNQGVKELVEYHLVESEKAELKESI 304
Query: 542 TLMAKVQADIKV 577
++ +K+
Sbjct: 305 EIIKDYNKRLKL 316
>UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3;
Lactococcus lactis|Rep: L-lactate dehydrogenase 3 -
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Length = 323
Score = 130 bits (313), Expect = 4e-29
Identities = 68/191 (35%), Positives = 109/191 (57%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+L V ++SGLPKHRVIG+GT L+++R R +++E+L I S HGY++ EHG SS
Sbjct: 130 DVLAQVVAEVSGLPKHRVIGTGTLLETSRMRQIVAEKLQINPKSIHGYVLAEHGKSSFAA 189
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + + L+ KK P + E+ + + + ++ KG TS+ I SL++L
Sbjct: 190 WSNVTVGAIPLTTWLKKYPNPEFP-TFDEIDQEIREVGLDIFMQKGNTSYGIAASLARLT 248
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAI N + + VS YL GE+G +++ P ++ +GV V+ LT+ E + + S
Sbjct: 249 RAIFRNESVILPVSAYLTGEYG-QFDLYTGSPAIIDRTGVRAVLELELTQEEQEKFKAST 307
Query: 542 TLMAKVQADIK 574
L+ + IK
Sbjct: 308 VLLKENFDSIK 318
>UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4;
Lactobacillus|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri
Length = 312
Score = 129 bits (311), Expect = 7e-29
Identities = 69/192 (35%), Positives = 113/192 (58%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILT + +ISG PK RVIG+GT+LDS R R LLS++L ++ ++GEHGD+S
Sbjct: 127 DILTTIAQRISGFPKERVIGTGTSLDSMRLRVLLSKKLHLSVNVIDALMLGEHGDTSFAA 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
++ + I G L+ + TD E+ + V ++ ++I KG T + I LS +
Sbjct: 187 FNEITIGGKALNIITALSNTDK-----SEIEKAVHEAGSQIIANKGGTFYGIAKCLSYIT 241
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAI+ N N V +S L G++GI+ +++L P ++ G+ V+ PLT E+ ++++SA
Sbjct: 242 RAIIENRNLVLPISAPLDGQYGIN-DLYLGTPAIINSQGIGQVVEYPLTSDEVKKMQQSA 300
Query: 542 TLMAKVQADIKV 577
M +V A I++
Sbjct: 301 EAMHQVLAKIEI 312
>UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
pulmonis|Rep: L-lactate dehydrogenase - Mycoplasma
pulmonis
Length = 315
Score = 128 bits (309), Expect = 1e-28
Identities = 70/191 (36%), Positives = 104/191 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DIL V K++ PK +V+ SGT LD++RFR LSE+ G+ T S HG++IGEHGD SV V
Sbjct: 123 DILATVFQKVTNFPKEKVMSSGTFLDTSRFRKFLSEKTGVPTNSVHGFVIGEHGDKSVVV 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S + I RL D K D W + E K AYE+I K T + IG S++++
Sbjct: 183 FSRMQIGFSRLDDFLKSKALTEDDLKW--ISEKTYKEAYEIINRKRSTYFGIGASVAEMA 240
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
++LYN + + YL E +++S P +LG +G +V L+ E +SA
Sbjct: 241 ESVLYNQRRIFPIGIYL-DESKPGGGIYISRPAILGENGWEEVKNYDLSPAEQKAFDESA 299
Query: 542 TLMAKVQADIK 574
+ K D++
Sbjct: 300 INLKKHWDDVQ 310
>UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3;
Fusobacterium nucleatum|Rep: L-lactate dehydrogenase -
Fusobacterium nucleatum subsp. nucleatum
Length = 318
Score = 126 bits (305), Expect = 3e-28
Identities = 67/185 (36%), Positives = 101/185 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+TY ++SG PK+RVIG+GT LDSAR + +LSE I + Y++GEHGD+ +
Sbjct: 124 DIVTYFVRELSGFPKNRVIGTGTGLDSARLKRILSEVTNIDSQVIQAYMLGEHGDTQIAN 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S I GV D K L + VV++A+++I K T + IG + S LV
Sbjct: 184 FSSATIQGVPFLDYMKTHPEQFKGVELSVLEKQVVRTAWDIISGKNCTEFGIGCTCSNLV 243
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AI +N V S YL GE+G + +P ++G +GV +++ PL E E +
Sbjct: 244 KAIFHNERRVLPCSAYLNGEYG-HSGFYTGVPAIIGSNGVEEILELPLDERERKGFEDAC 302
Query: 542 TLMAK 556
+M K
Sbjct: 303 AVMKK 307
>UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 329
Score = 125 bits (301), Expect = 1e-27
Identities = 72/192 (37%), Positives = 108/192 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TY + ++ G+GT LDS+RFRYL+++R IA + H +IGEHGDS +P+
Sbjct: 139 DVVTYAASSVVDAQPGQIFGTGTVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGDSEIPL 198
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS ++I GV D + VV +AYE+I KG T+ AIGL+ +++V
Sbjct: 199 WSTLSIGGVGADAYRVDGRLVFDEPTRTAVATDVVNAAYEIIAGKGATNLAIGLATARVV 258
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
A+L + + V VST G +GI V LSLP V+ G V+ L+ EL LR+SA
Sbjct: 259 EAVLGDQHRVLPVSTVQDGAYGI-TGVALSLPTVVSAGGARRVLEVELSPGELDGLRRSA 317
Query: 542 TLMAKVQADIKV 577
+A V+ + +
Sbjct: 318 QTLADVRRSLGI 329
>UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8;
Lactobacillus|Rep: L-lactate dehydrogenase 2 -
Lactobacillus plantarum
Length = 309
Score = 124 bits (300), Expect = 1e-27
Identities = 67/183 (36%), Positives = 111/183 (60%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILT +T ++SG P+HRVIG+GT+LD+AR R L+++L +ATT+ ++GEHGDSS+
Sbjct: 125 DILTSMTQRLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVDAAVLGEHGDSSI-- 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
VN + ++ K T D + E+ + V ++I KG T + + +SL Q+
Sbjct: 183 ---VNFDEIMINAQPLKTVTTVDDQFKAEIEQAVRGKGGQIISQKGATFYGVAVSLMQIC 239
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAIL + N+ VS L G++GI+ +++L P ++ +G+ VI L++ E A+++ A
Sbjct: 240 RAILNDENAELIVSAALSGQYGIN-DLYLGSPAIINRNGLQKVIEAELSDDERARMQHFA 298
Query: 542 TLM 550
M
Sbjct: 299 AKM 301
>UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 323
Score = 124 bits (299), Expect = 2e-27
Identities = 68/180 (37%), Positives = 101/180 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TY K SG P H VIGSGT+LDSARF L + L I S H +IGEHG+S +PV
Sbjct: 133 DVMTYAAVKFSGFPAHSVIGSGTSLDSARFAGELGKHLNIDPRSLHAVVIGEHGESELPV 192
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS ++G+R+ D ++ GT D E K+ V +A +I+ KG T + I +L ++V
Sbjct: 193 WSLATVSGMRVEDYCRQTGTPWDEETKKQCFANVKDAAAAIIEKKGVTGYGIASALLRIV 252
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+ + N++ VS G + ++V LS+P L G + + L++ E LR SA
Sbjct: 253 ECVRRDENTLMPVSCV--GSYAGVDDVALSVPRKLNRYGCMEYVPMMLSKEEEGSLRASA 310
>UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;
n=2; Bacteria|Rep: Lactate/malate dehydrogenase
precursor - Bacillus coagulans 36D1
Length = 327
Score = 124 bits (298), Expect = 2e-27
Identities = 63/191 (32%), Positives = 110/191 (57%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + Y+ G K R+ G+GT LDSAR R L++E I S GY++GEHG ++ PV
Sbjct: 130 DTIVYIAENEFGYSKGRIFGTGTMLDSARLRQLVAENYSIDPKSVTGYMMGEHGFTAFPV 189
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S +N+ G R +L+ + +P + + + VVK+A++V+ KG+T+ + + L
Sbjct: 190 FSRLNVQGFREKELDS-VFKGKEPLDREAFRQKVVKTAFDVLNGKGWTNAGVAEAAVTLA 248
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+A++ + S++ VS L G++G + +V LS+P V+G +G+ + L E E + L +SA
Sbjct: 249 KAVMLDEKSIYPVSATLHGQYGYNGDVALSIPSVIGRNGIEQQLEIELDEQETSWLHESA 308
Query: 542 TLMAKVQADIK 574
+ A +K
Sbjct: 309 KSIQNTMASVK 319
>UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula
stellata E-37|Rep: L-lactate dehydrogenase - Sagittula
stellata E-37
Length = 300
Score = 123 bits (297), Expect = 3e-27
Identities = 73/183 (39%), Positives = 103/183 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+T+VT +SGLP RVIGSGT LD+ARFR+LL L IA S H Y++GEHGD+ V
Sbjct: 111 DIMTHVTQALSGLPAGRVIGSGTILDTARFRWLLGRHLNIAPRSVHAYVLGEHGDTEVLA 170
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
W+ V + +I + + + + V +AY +I+ KG T + IG L++LV
Sbjct: 171 WTAARAGSVSIESFAAQIRAPLTADVRERIDKGVRNAAYTIIEGKGATWYGIGAGLARLV 230
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AI + +V VST L G+ V SLP V+G GV+ + ++ E A L SA
Sbjct: 231 AAIGSDEQTVLTVST-LSDVAGV-RRVACSLPRVVGREGVTAELMPDISRQENAALEASA 288
Query: 542 TLM 550
L+
Sbjct: 289 MLL 291
>UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: L-lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 312
Score = 122 bits (295), Expect = 6e-27
Identities = 67/183 (36%), Positives = 105/183 (57%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+L + + SGLP+++V+GSGT LDSAR R + R + HGYI+GEHGDS PV
Sbjct: 124 DVLAELVLQESGLPRNQVLGSGTALDSARLRSEIGLRYNVDARIVHGYIMGEHGDSEFPV 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
W NI G + D I D ++ ++ E V +AY +I+ KG T + I SL++L
Sbjct: 184 WDYTNIGGKPILDW---IPKDRQDKDLPDISERVKTAAYGIIEKKGATFYGIAASLTRLT 240
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
A L + + A+S +L+GE+G+ V + +P +LG +G+ +I L + +L SA
Sbjct: 241 SAFLNDDRAAFAMSVHLEGEYGL-SGVSIGVPVILGANGLERIIELDLNPEDHKRLADSA 299
Query: 542 TLM 550
++
Sbjct: 300 AIL 302
>UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
genitalium
Length = 312
Score = 122 bits (295), Expect = 6e-27
Identities = 64/183 (34%), Positives = 105/183 (57%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI++Y K++G ++VIGSGT LDSAR RY ++ + +++ Y+IGEHGDSSV +
Sbjct: 125 DIMSYTYLKVTGFEPNKVIGSGTLLDSARLRYAIATKYQMSSKDVQAYVIGEHGDSSVSI 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
S IAG+ L +K +D + E + E+ + + + AYE+I+ KG T + IG + + +
Sbjct: 185 ISSAKIAGLSLKHFSK--ASDIEKE-FGEIDQFIRRRAYEIIERKGATFYGIGEASADVA 241
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
IL + V V+ L G++G + +F PCVL G+ ++ L+ TE L S
Sbjct: 242 EQILKDTKEVRVVAPLLTGQYGAKDMMF-GTPCVLSRKGIEKILEIELSNTEKVALENSI 300
Query: 542 TLM 550
++
Sbjct: 301 KVL 303
>UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 321
Score = 122 bits (294), Expect = 7e-27
Identities = 66/176 (37%), Positives = 101/176 (57%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D L ++ P+ V+G+GT LDSAR ++++ LG+ GY+IGEHG S P+
Sbjct: 133 DALVHIASTEFDHPQGLVLGTGTILDSARMCRVVADHLGVDPDYVRGYMIGEHGPSGFPM 192
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
++GVN+ GV L K D+DP + EL + + V LKG+TS IG S +
Sbjct: 193 FTGVNVGGVGFDGLAKLF--DADPMDRDELTTRINDAGTAVFNLKGWTSAGIGQSAITIA 250
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQL 529
R+IL N ++V+ V T L G++G D +V + +PCV+G +GV ++ PL + E L
Sbjct: 251 RSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGATGVERILEVPLDDWEQEHL 306
>UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2;
Ascomycota|Rep: Probable L-lactate dehydrogenase -
Schizosaccharomyces pombe (Fission yeast)
Length = 330
Score = 120 bits (290), Expect = 2e-26
Identities = 67/179 (37%), Positives = 105/179 (58%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTY T K++G P RVIGSGT +D+ARF+YL+ + G+ S + IIGEHGDS + V
Sbjct: 140 DVLTYATLKLTGFPAERVIGSGTIIDTARFQYLIGKLYGLDPQSVNADIIGEHGDSELAV 199
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS +IAG+ L+D ++ T D + E + +AY++I+ KG T + + L +++
Sbjct: 200 WSHASIAGLSLADFCEESETKYDEQALNECFKETKNAAYDIIQRKGSTEYGVAAGLVRIL 259
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AI+ + N++ VS L I + F S+P L G +I L++ E A+L +S
Sbjct: 260 AAIIRDENALLTVSG-LDSYSNIGDVCF-SMPRKLNKDGAHRIINAKLSKDEDAKLVES 316
>UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 319
Score = 120 bits (290), Expect = 2e-26
Identities = 64/180 (35%), Positives = 102/180 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT V + +GLP +RV +GT LD++R R+L+ + + H I+GEHGDS P+
Sbjct: 130 DVLTVVAQEATGLPANRVFSTGTMLDTSRLRWLIRQWANVEQRHVHATIVGEHGDSEFPL 189
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS NI+GV + D + +L +AY++I+ KG T++AIGL+ ++L
Sbjct: 190 WSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGATNYAIGLTGARLA 249
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
A+L SV +S+ + HGI V LS+PC++ G+ V+ + E+A L+ SA
Sbjct: 250 EALLRPGRSVLPLSSVMTDMHGI-SGVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASA 308
>UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate
dehydrogenases; n=2; Nostoc punctiforme PCC 73102|Rep:
COG0039: Malate/lactate dehydrogenases - Nostoc
punctiforme PCC 73102
Length = 317
Score = 119 bits (287), Expect = 5e-26
Identities = 63/180 (35%), Positives = 95/180 (52%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT + S ++ + GSGT LD+AR RY L ++L +A H Y+IGEHGDS V
Sbjct: 127 DVLTRIAQATSTRAENLIFGSGTVLDTARLRYQLGKQLNVAKQDIHAYVIGEHGDSQFVV 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS I G+ L++ G + + +E ++ K Y + + KGYTS+ I + QLV
Sbjct: 187 WSSAFIGGILLTEFPIPQGATLE-QIQQEYAQLTRKRGYNIFERKGYTSYGISTVVCQLV 245
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
IL + + VST +G+ EV L LPC++G +G+ + E L +SA
Sbjct: 246 DTILRDEKQIFPVSTRADSNYGVGSEVVLGLPCIIGSTGIERQLLLSRNALEQRLLEESA 305
>UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6;
Mollicutes|Rep: L-lactate dehydrogenase - Mesoplasma
florum (Acholeplasma florum)
Length = 317
Score = 119 bits (286), Expect = 7e-26
Identities = 67/180 (37%), Positives = 105/180 (58%), Gaps = 1/180 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT V +++G +H V+G+GT LDSAR R L++E+L +A S + YI+GEHGDSSV
Sbjct: 126 DVLTTVYQQVTGYDEHSVVGAGTTLDSARLRRLVAEKLNVAPKSVNAYIMGEHGDSSVAA 185
Query: 182 WSGVNIAGVRLSD-LNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
+S + G +S L + T++D E E ++ AYE+I+ KG T + IG+ L+ +
Sbjct: 186 YSKATVMGQPISKYLAEGKITEADLE---ECWTRAIRMAYEIIERKGATYYGIGVCLNAI 242
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AIL + + V L GE+G + + +P +LG G +I L++ E A +KS
Sbjct: 243 SSAILRDEKTTFMVGAKLNGEYG-QKGFYTGVPVILGSKGWETIIEWDLSDAEKAAFKKS 301
>UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 325
Score = 118 bits (285), Expect = 9e-26
Identities = 63/179 (35%), Positives = 103/179 (57%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ W ++G ++IGSG LDSAR R +S+++G++ S Y+IGEHG S +
Sbjct: 127 DVVCTELWHLTGYDPKKIIGSGCGLDSARLRTEISKKVGVSPKSVDAYMIGEHGFSQLAA 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+ IAG L++L + D + E+ E+ K Y + K T +A+ S +++
Sbjct: 187 FKAATIAGKSLNELQAE-NPDKYAFDHMEVEELARKGGYVTYQGKQCTEYAVANSAARVC 245
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
A+L+N ++V + ST + G++G +E +F SLPCV+G GV +V L+E EL L KS
Sbjct: 246 AAVLHNEHAVLSASTLMTGQYG-EEGIFTSLPCVIGAEGVEEVYTLDLSEHELEGLHKS 303
>UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18;
Bacteria|Rep: L-lactate dehydrogenase 2 - Listeria
innocua
Length = 311
Score = 118 bits (284), Expect = 1e-25
Identities = 66/184 (35%), Positives = 103/184 (55%), Gaps = 1/184 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+TY WK+SGLP+ +V+G+G LD+ R R LL+E+L IA S +I+GEHGDS PV
Sbjct: 125 DIITYQVWKLSGLPREQVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDSQFPV 184
Query: 182 WSGVNIAGVRLSDLN-KKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS +I G +++ + +K+G D K + E + +E+ KG T + I ++ ++
Sbjct: 185 WSHSSIYGKPVNEYSMEKLGESLD---LKLIGETARDTGFEIYHQKGCTEYGIAGTIVEI 241
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
R I + VS L GE+G + + +P VL +GV ++I L E E S
Sbjct: 242 CRHIFSGSQRALTVSCVLDGEYG-QTGLAIGVPAVLSQNGVKEIISLKLNEQEQQAFDHS 300
Query: 539 ATLM 550
A ++
Sbjct: 301 AAVI 304
>UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizopus
oryzae|Rep: L-lactate dehydrogenase A - Rhizopus oryzae
(Rhizopus delemar)
Length = 320
Score = 117 bits (281), Expect = 3e-25
Identities = 69/199 (34%), Positives = 104/199 (52%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILT++ +SGLP ++VIGSGT LD+ R R L + + S H +++GEHGDS +
Sbjct: 123 DILTHIAKTLSGLPPNQVIGSGTYLDTTRLRVHLGDVFDVNPQSVHAFVLGEHGDSQMIA 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
W +I G L+ + D + + + A E+I+LKG T + IG + LV
Sbjct: 183 WEAASIGGQPLTSFPEFAKLDK-----TAISKAISGKAMEIIRLKGATFYGIGACAADLV 237
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
I+ N SVH VS Y++ ++G S+P LG GV + PLTE E A L KS
Sbjct: 238 HTIMLNRKSVHPVSVYVE-KYG----ATFSMPAKLGWRGVEQIYEVPLTEEEEALLVKSV 292
Query: 542 TLMAKVQADIKVLIIRRLH 598
+ V+ + +++H
Sbjct: 293 EALKSVEYSSTKVPEKKVH 311
>UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2;
Euryarchaeota|Rep: Malate dehydrogenase - Methanopyrus
kandleri
Length = 317
Score = 116 bits (279), Expect = 5e-25
Identities = 68/197 (34%), Positives = 107/197 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTYV K+SGLPK+RVIG GT+LDS RF+ L+++ + + H IIGEHGD+ VPV
Sbjct: 126 DVLTYVALKVSGLPKNRVIGLGTHLDSMRFKVLIAKHFNVHMSEVHTRIIGEHGDTMVPV 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
S ++ G+ ++ + D D E E V ++ +I+ G + + +++ LV
Sbjct: 186 ISSTSVGGIPVTRMPG--WEDFDVE---EAVREVKEAGQRIIETWGGSQFGPAQAITNLV 240
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
R IL + V VS YL GE +V + +P LG GV +++ L E E+ R+S
Sbjct: 241 RTILQDERRVLTVSAYLDGEIDGIRDVCIGVPARLGREGVLEIVPIELEEDEMRAFRRSV 300
Query: 542 TLMAKVQADIKVLIIRR 592
++ + + I R
Sbjct: 301 KVVKEATREAMEAISER 317
>UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae
Length = 315
Score = 116 bits (279), Expect = 5e-25
Identities = 64/189 (33%), Positives = 103/189 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+T SG +VIGSGT LD+AR ++ +++R ++ S Y++GEHGDSS
Sbjct: 124 DIITRAYRDASGFSDQKVIGSGTVLDTARLQFAIAKRAKVSPNSVQAYVMGEHGDSSFVA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S + IAG +K G DS KEL V + AYE+I K T + IG +++++V
Sbjct: 184 YSNIKIAGECFCAYSKLTGIDSSNYE-KELEYPVSRRAYEIINRKRATFYGIGAAIAKIV 242
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
I+ + ++ L+GE+G V + +P VLG +G+ +I L + E + KS
Sbjct: 243 SNIIKDTKNIMIAGANLRGEYGF-HGVNIGVPVVLGANGIEKIIEISLNDKEKEKFAKSV 301
Query: 542 TLMAKVQAD 568
++ K+ D
Sbjct: 302 AIIDKIYQD 310
>UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3;
Bifidobacterium longum|Rep: L-lactate dehydrogenase 1 -
Bifidobacterium longum
Length = 316
Score = 116 bits (278), Expect = 6e-25
Identities = 58/183 (31%), Positives = 104/183 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ + WK SGLP+ +V+G+GT LD++R + ++ E G+ + G+++GEHGDS
Sbjct: 127 DVMAWYAWKRSGLPRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTA 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V++ G + + E+ E E++ KG T++ I +++ +V
Sbjct: 187 WSTVSLGGKPFARFLADNQDRFASVSTTEIEEKTRTRGNEIVAAKGGTNFGIASTVAGIV 246
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+ IL++ + VST L GE+G + +VFL +P L +G ++++ L+E E A+L SA
Sbjct: 247 QTILWDERRIVPVSTLLDGEYG-EHDVFLGVPTELRANGANEIVELDLSEDERAKLHHSA 305
Query: 542 TLM 550
L+
Sbjct: 306 ELV 308
>UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4;
Bacteria|Rep: L-lactate dehydrogenase - Blastopirellula
marina DSM 3645
Length = 313
Score = 114 bits (275), Expect = 1e-24
Identities = 69/183 (37%), Positives = 99/183 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTY+ + LP RVIG GT LD+ RFR L+++ + + T I+GEHGDS +PV
Sbjct: 123 DILTYLAAQRLNLPTSRVIGLGTQLDTIRFRALIAQEMKLPPTQVKALILGEHGDSMLPV 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS + G+ L+K G P EL S EVIK KG +A+G+++ ++
Sbjct: 183 WSAATVNGL---PLDKFPGW--TPNKATELFTRTRGSGAEVIKKKGGAGFAVGIAIRDVI 237
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AI + N V VS+ G +GI V LS+P ++G GV+ L E+ QLR S
Sbjct: 238 EAIALDKNQVLPVSSVQNGCYGI-RNVALSVPTLVGRDGVAGTFEVDLWPKEMQQLRHSG 296
Query: 542 TLM 550
++
Sbjct: 297 QVL 299
>UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 312
Score = 114 bits (274), Expect = 2e-24
Identities = 63/188 (33%), Positives = 105/188 (55%), Gaps = 5/188 (2%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+ K +GLPK+RV +GT+LD+AR R +++ IA S G+ +GEHGDSS+
Sbjct: 125 DIIADFVRKATGLPKNRVFSTGTSLDTARMRRTVADLCNIAPQSVIGFAMGEHGDSSMVP 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKS-----AYEVIKLKGYTSWAIGLS 346
+S + I G L + +PE + +L E V+ ++I+ KG T + IG +
Sbjct: 185 FSNLTIFGKNYKHLK-----EENPERFGKLSEKVITDQTHMRGMDIIEGKGSTEFGIGTA 239
Query: 347 LSQLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQ 526
L+ + +A+L + + + ST L+GE+G V +PC++G +G+ V+ LT+ EL Q
Sbjct: 240 LADMAKAVLMDEHRILPASTLLEGEYG-QTNVHAGVPCIIGRNGIEQVVELKLTDEELKQ 298
Query: 527 LRKSATLM 550
S ++
Sbjct: 299 FENSCNVI 306
>UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14;
Thermoprotei|Rep: Malate dehydrogenase - Pyrobaculum
aerophilum
Length = 309
Score = 111 bits (266), Expect = 2e-23
Identities = 66/191 (34%), Positives = 106/191 (55%), Gaps = 1/191 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +TYV WK +G P+ RVIG LD+ R + +++LGI+ S ++G+HG+S PV
Sbjct: 121 DAMTYVMWKATGFPRERVIGFSGVLDAGRLAFYAAKKLGISPASILPIVLGQHGESMFPV 180
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS-WAIGLSLSQL 358
S + GV LS K+ T+ E KE+ E VK+ + +L+G++S W G L+ +
Sbjct: 181 PSKSYVHGVPLS----KLLTE---EQLKEVVEETVKAGARITELRGFSSNWGPGAGLAIM 233
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
A+ +A S L+GE+G+ +V + +P +LG SGV V+ LTE E + +S
Sbjct: 234 AEAVKRDAKRALIASVVLQGEYGV-RDVPVEVPIILGRSGVVKVLEVELTEEERQKFMQS 292
Query: 539 ATLMAKVQADI 571
+ K+ A +
Sbjct: 293 VEAVKKLVASV 303
>UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep:
Lin1775 protein - Listeria innocua
Length = 302
Score = 109 bits (262), Expect = 6e-23
Identities = 61/185 (32%), Positives = 99/185 (53%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T + KISG RV G+GT+LD+AR R ++ E L I S GY++GEHG+S
Sbjct: 123 DVITMLIQKISGFDHSRVFGTGTSLDTARMRRVVGEALHINPKSIEGYVLGEHGESQFVA 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V I GV ++D K P + L + V + ++ KG+TS+ I + + +V
Sbjct: 183 WSTVKIGGVNITDYKTK-----TPLDLPALKDAVRGGGWNILTGKGWTSFGIATATAGIV 237
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
A+L +A V ++ + + ++ P ++G +GV D I+ PLT+ E SA
Sbjct: 238 DALLTDAKQVFPLAVFSE-----QTNTYIGQPALIGANGVLDTIKPPLTKEEQTNFEHSA 292
Query: 542 TLMAK 556
++ K
Sbjct: 293 EVIRK 297
>UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10;
Campylobacter|Rep: L-lactate dehydrogenase -
Campylobacter jejuni
Length = 308
Score = 109 bits (262), Expect = 6e-23
Identities = 64/180 (35%), Positives = 96/180 (53%), Gaps = 1/180 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +TY T +S LPK+ V GSGTNLDS+R + LL++ L I + +IGEHGDS
Sbjct: 124 DTITYYTQVLSQLPKNHVFGSGTNLDSSRLKKLLAKDLNINSKDIFACMIGEHGDSQFAA 183
Query: 182 WSGVNIAGVRLSDLNK-KIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
S ++ G L D K K+G D D + EL + V+ Y + + KG T + IG S + L
Sbjct: 184 LSNASVLGQNLLDFYKQKLGKDLDIQ---ELEKAVISEGYFIYERKGRTEFGIGTSCANL 240
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+AIL + S++ VS + +++ S+P ++G G+ V E E +L S
Sbjct: 241 AKAILEDRKSLYPVSV-------VFDDIAFSMPAIIGKDGIEKVFELKFNEKEKIKLENS 293
>UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomonas
ruminantium|Rep: L-lactate dehydrogenase - Selenomonas
ruminantium
Length = 318
Score = 109 bits (262), Expect = 6e-23
Identities = 53/180 (29%), Positives = 110/180 (61%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+ TYV P++ ++G+GT L++ RFR +L+++ + + +GY++GEHG+++
Sbjct: 128 DVATYVVSTQFDYPRNLILGTGTMLETYRFRRILADKYQVDPKNINGYVLGEHGNAAFVA 187
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS AG + DL++ ++ + + + + +V+ AY+VI KG+T+ I ++ + +
Sbjct: 188 WSTTGCAGFPIDDLDEYFHR-TEKLSHEAVEQELVQVAYDVINKKGFTNTGIAMAACRFI 246
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+++LY+ +++ S L+GE+GI ++V LS+P ++ G+ LT+ EL ++ K+A
Sbjct: 247 KSVLYDEHTILPCSAVLEGEYGI-KDVALSIPRMVCADGIMRSFEVHLTDDELEKMHKAA 305
>UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=2;
Oenococcus oeni|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 304
Score = 109 bits (261), Expect = 7e-23
Identities = 67/185 (36%), Positives = 103/185 (55%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T V + LPK++VIG+GT LDS+R + + ER I S G++IGEHG+S P
Sbjct: 124 DVITAVYQRELALPKNQVIGTGTFLDSSRLKKEIGERFKIDPRSVSGFVIGEHGNSQFPA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS + I +S K+ + D +L E + A+ VI KGYT+ AI + + L+
Sbjct: 184 WSSIRIFDNPISSFAKENSVNID-----DLEEKTKEDAFRVIDGKGYTNIAIATAAATLI 238
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
IL +++S VS Y K + GI ++SLP ++G G+ I PL + E +L+ SA
Sbjct: 239 EMILSDSHSEVIVSHYNK-KFGI----YISLPAIIGRKGIVKDIYLPLDQKESTKLKTSA 293
Query: 542 TLMAK 556
+ K
Sbjct: 294 ESIIK 298
>UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
gallisepticum|Rep: L-lactate dehydrogenase - Mycoplasma
gallisepticum
Length = 323
Score = 108 bits (260), Expect = 1e-22
Identities = 62/194 (31%), Positives = 105/194 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ V K++G H++I +G L++ R R ++SE LG+ + S G+++GEHG ++
Sbjct: 129 DVMAGVYQKVTGFDPHKIISTGCQLETMRTRKMISEALGVNSDSVEGFVVGEHGSGAIVP 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS + V + L + G + E K++ VVK A+E+IK K T + I S+S +
Sbjct: 189 WSVFRVGNVPMKQLIAE-GKIKE-EYVKDIFSRVVKEAFEIIKFKKATYFGIAESMSLIT 246
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RA +YN N+V V L ++ + ++ ++P V+G G + L++ E A KSA
Sbjct: 247 RAYIYNLNTVLGVGVQLDDKY-VASGIYFTVPAVVGKHGWKLHSKLQLSQEEQAAFDKSA 305
Query: 542 TLMAKVQADIKVLI 583
+ KV D LI
Sbjct: 306 LNIQKVTKDALDLI 319
>UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7;
Bacteria|Rep: L-lactate dehydrogenase - Deinococcus
radiodurans
Length = 304
Score = 107 bits (258), Expect = 2e-22
Identities = 64/183 (34%), Positives = 104/183 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT + +++ P VIGSGT LDSARFR+L+++ G+ T HGY++GEHGDS V
Sbjct: 120 DLLTDLATQLA--PGQPVIGSGTVLDSARFRHLMAQHAGVDGTHAHGYVLGEHGDSEVLA 177
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS +AG+ ++D + + + ++ E +A +I+ K T + IG +L+++
Sbjct: 178 WSSAMVAGMPVADFMQAQNLPWNEQVRAKIDEGTRNAAASIIEGKRATYYGIGAALARIT 237
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
A+L + +V VS E+G+ LSLP V+G GV + LT E +L +SA
Sbjct: 238 EAVLRDRRAVLTVSAPTP-EYGVS----LSLPRVVGRQGVLSTLHPKLTGDEQQKLEQSA 292
Query: 542 TLM 550
++
Sbjct: 293 GVL 295
>UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2;
Gammaproteobacteria|Rep: Lactate dehydrogenase -
Reinekea sp. MED297
Length = 319
Score = 106 bits (255), Expect = 4e-22
Identities = 62/192 (32%), Positives = 103/192 (53%), Gaps = 1/192 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI TY + +G P RVI +G +D+AR L+SE++ + + GYI+GEHG
Sbjct: 123 DIATYFITQNTGFPADRVISAGCIIDTARLMKLVSEKVDVDPKNVSGYILGEHGSHCFMP 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDS-DPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
W V +AG + + G D+ DP+ L E V ++ +E+ K K T+ I S+ ++
Sbjct: 183 WGLVGVAGQPIDYYCQHNGFDAIDPQT---LLEEVKQAGFEIFKRKHNTTHGIAASVFRM 239
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
++AI + S+ V T L G +G+ +V LSLP ++ G V+ P +ETE +L
Sbjct: 240 IQAITIDEYSILPVGTLLSGHYGL-SDVVLSLPTIVNARGAHKVLEHPFSETETRELHDI 298
Query: 539 ATLMAKVQADIK 574
A + K+ +++
Sbjct: 299 AAALQKLIREVQ 310
>UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
phytofermentans ISDg|Rep: L-lactate dehydrogenase -
Clostridium phytofermentans ISDg
Length = 319
Score = 105 bits (253), Expect = 7e-22
Identities = 59/183 (32%), Positives = 99/183 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T+ + +++I + T LDSAR R +++ + I S +G+++GEHG+S +
Sbjct: 127 DVITHYLQHLLQYSSNKIISTSTVLDSARLRRAIADAVEIDQKSIYGFVLGEHGESQMVA 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V+IAG + +L K+ + +L + + ++ KG T + IG SL+++
Sbjct: 187 WSTVSIAGKPILELIKEKPEKYGQIDLSKLSDEARAGGWHILTGKGSTEFGIGASLAEVT 246
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAI + V VST L GE+G +V+ S+P VLG GV ++I LT E + S
Sbjct: 247 RAIFSDEKKVLPVSTLLNGEYG-QHDVYASVPTVLGIHGVEEIIELNLTPEEKGKFDASC 305
Query: 542 TLM 550
M
Sbjct: 306 RTM 308
>UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|Rep:
Malate dehydrogenase 1 - Aquifex aeolicus
Length = 335
Score = 105 bits (251), Expect = 1e-21
Identities = 62/189 (32%), Positives = 101/189 (53%), Gaps = 4/189 (2%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TYV +K+ PK+RV+G LDSARF+ +SE L ++ H Y+IG HGD VP+
Sbjct: 138 DVMTYVAYKLLNFPKNRVMGMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDEMVPL 197
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS-WAIGLSLSQL 358
S N+ G+ L DL K E +++ E E++ L G ++ +A ++ +
Sbjct: 198 ISISNVGGIPLKDLLPK-------EKLEKIIERTRFGGGEIVNLMGTSAYYAPAAAIVDM 250
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEV---FLSLPCVLGHSGVSDVIRQPLTETELAQL 529
+ A++ N+ + S YL GE G V + +P LG +GV ++I+ P+ E E
Sbjct: 251 IEALVQNSKRILPCSVYLDGEAGEYYGVQGFCVGVPVKLGSNGVEEIIKVPMIEEEREMW 310
Query: 530 RKSATLMAK 556
R+S + K
Sbjct: 311 RRSVESVKK 319
>UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2;
Planctomycetaceae|Rep: L-lactate/malate dehydrogenase -
Rhodopirellula baltica
Length = 304
Score = 104 bits (249), Expect = 2e-21
Identities = 65/191 (34%), Positives = 100/191 (52%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D L Y T +++G RVIG+GT +DS R+R LLS L I YI+GEHGD+
Sbjct: 122 DALAYETIRLTGFDPKRVIGTGTLVDSIRYRALLSTELKIHAQDIRAYILGEHGDTQFAA 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
S G R +D+ ++E M YEV +LKG+TS+ I ++ ++
Sbjct: 182 SSIAMTGGERF------YPSDTSRRMFEETKAM----GYEVFRLKGHTSYGIAMATITIL 231
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+I Y+ VS + G G+ E+V LSLP V+G GV+ ++ L+E E A R SA
Sbjct: 232 DSIAYDLRHTMPVSVLVDGYLGV-EDVCLSLPAVIGREGVTRILHPTLSEDEEAAFRNSA 290
Query: 542 TLMAKVQADIK 574
++ + +++
Sbjct: 291 EVVKQTLVEME 301
>UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 322
Score = 103 bits (248), Expect = 3e-21
Identities = 60/178 (33%), Positives = 98/178 (55%)
Frame = +2
Query: 41 PKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVWSGVNIAGVRLSD 220
P + V+G+GT LDSAR R L++ G++ S +++GEHG ++ P S +I G+ L++
Sbjct: 145 PTNLVVGTGTALDSARLRRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTLAE 204
Query: 221 LNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLVRAILYNANSVHAV 400
+G P + ++ VV+SA+++++ KG+TS I + L RA+L + S+H V
Sbjct: 205 ATTALGLQ--PLSPDQVGNSVVQSAFDILEGKGWTSSGISKAAVSLARAMLLDQRSIHPV 262
Query: 401 STYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSATLMAKVQADIK 574
T G G EV LSLP V+ GV + L E E +L SA + +V ++
Sbjct: 263 CTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKLLVSAKAVREVYESVR 320
>UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Rep:
Malate dehydrogenase - Brucella melitensis
Length = 320
Score = 103 bits (247), Expect = 4e-21
Identities = 61/186 (32%), Positives = 97/186 (52%), Gaps = 2/186 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + + K SGLP H+V+G LDSARFRY LSE ++ +++G HGDS VP+
Sbjct: 124 DAMVWALQKFSGLPAHKVVGMAGVLDSARFRYFLSEEFNVSVEDVTAFVLGGHGDSMVPL 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
+AG+ LSDL K T D ++ + E++ L G +A S Q
Sbjct: 184 ARYSTVAGIPLSDLVKMGWTSQD--KLDKIIQRTRDGGAEIVGLLKTGSAFYAPAASAIQ 241
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+ + L + V V+ L G++G+ +++++ +P V+G +GV +I L + E AQ K
Sbjct: 242 MAESYLKDKKRVLPVAAQLSGQYGV-KDMYVGVPTVIGANGVERIIEIDLDKDEKAQFDK 300
Query: 536 SATLMA 553
S +A
Sbjct: 301 SVASVA 306
>UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4;
Eutheria|Rep: L-lactate dehydrogenase - Homo sapiens
(Human)
Length = 253
Score = 103 bits (246), Expect = 5e-21
Identities = 42/64 (65%), Positives = 54/64 (84%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTYV WK+S PK+RVIGSG NLD+ RF++ + ++LGI + SC G+I+GEHGDSSVPV
Sbjct: 190 DILTYVAWKLSAFPKNRVIGSGCNLDTVRFQFFIGQKLGIHSESCRGWILGEHGDSSVPV 249
Query: 182 WSGV 193
WSG+
Sbjct: 250 WSGM 253
>UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3;
Methanomicrobiales|Rep: L-lactate dehydrogenase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 319
Score = 102 bits (245), Expect = 6e-21
Identities = 63/183 (34%), Positives = 99/183 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+T V K SG+ HRV G GT+LDS R + L+E + + H IIGEHGD+ VP+
Sbjct: 126 DIMTTVALKYSGMMPHRVFGLGTHLDSMRLKACLAEFFNVHVSEIHTRIIGEHGDTMVPM 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS + G+++ +L +G P +E+ + V S +I+ KG T + G +++ L+
Sbjct: 186 WSATTVGGIQIDNL---LGVAKLPR--EEMIQRVKSSGSYIIEAKGATVYGPGDAIATLI 240
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
R I+ + N + V+T ++ E E V +S+P + GV I L+E E KS
Sbjct: 241 RTIVEDENRMLTVATQIRREVFGHEGVCVSVPARITRGGVFP-IGVKLSEEEEQMFAKSV 299
Query: 542 TLM 550
L+
Sbjct: 300 KLI 302
>UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 330
Score = 101 bits (243), Expect = 1e-20
Identities = 62/192 (32%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +T +T ++G PK+RV+G LD+ARF + ++E LG+ + +G HGD+ VPV
Sbjct: 140 DEMTALTQLVTGFPKNRVMGQAGMLDTARFSHFVAEELGVPIRAVRTLTLGSHGDTMVPV 199
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
S V + +++ PE +EL E E++ L G +A + ++
Sbjct: 200 PSQ---CFVTIDGEQRRLADLVPPEKIQELVERTRNGGGEIVALLKTGSAYFAPSAAAAR 256
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+ RA+ ++ V V ++ GE+GI V+L + +G GV V+ PLTE+ELA L +
Sbjct: 257 MARAVAEDSGQVLPVCAWVDGEYGI-HGVYLGVEAEIGAQGVRRVVTTPLTESELAALHE 315
Query: 536 SATLMAKVQADI 571
+A +A QAD+
Sbjct: 316 AARAVAAKQADV 327
>UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 304
Score = 101 bits (243), Expect = 1e-20
Identities = 60/179 (33%), Positives = 98/179 (54%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + Y+T+K+SG + RV G G LD +RFR + E G + S +IGEHG++ +P+
Sbjct: 121 DPMAYITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEHGENMLPL 180
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+++G+ L L K E +EL + + A +VI+LKG T A G ++S +V
Sbjct: 181 PRFSSVSGIPLPSLLPK-------EKLEELVQNTKQVAAKVIELKGATVHAPGNAISAIV 233
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
A++ + V V+TYL GE+ +V + +P V+G +GV +I L + E K+
Sbjct: 234 EAVVRDRKQVIPVATYLDGEYD-HSDVTIGVPAVIGKNGVEKIIELDLNDEEKQVFNKA 291
>UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1;
Blastopirellula marina DSM 3645|Rep: L-lactate/malate
dehydrogenase - Blastopirellula marina DSM 3645
Length = 308
Score = 101 bits (242), Expect = 1e-20
Identities = 56/180 (31%), Positives = 92/180 (51%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T+ ++SG P+ RV G GT LD+AR R LLSER + + Y+IGEHG+ V
Sbjct: 122 DVMTWFALQLSGFPQERVFGVGTLLDTARLRRLLSERWSVHASDVRAYVIGEHGEDQVAS 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S ++ G + ++ L +SA ++ + +G+T++ I + ++
Sbjct: 182 FSSASLGGEAM----------KPSDDLASLARQAAESAGKIYRTRGFTNYGIAGATMMIL 231
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+I N VS + HG+ +V LSLP V+G G+ V+R L E E A + A
Sbjct: 232 ESIRNNRRRTAPVSMRINNYHGV-SDVCLSLPAVIGRRGIERVLRPELNEAEQATFHRGA 290
>UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;
Theileria|Rep: L-lactate dehydrogenase, putative -
Theileria annulata
Length = 367
Score = 101 bits (242), Expect = 1e-20
Identities = 60/193 (31%), Positives = 106/193 (54%), Gaps = 2/193 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ ++ K++G PK+ V+G G LDS+R ++E+LG+ HG +IG HGDS +P+
Sbjct: 178 DVMVHLMLKVTGFPKNMVVGMGGLLDSSRMNCYIAEKLGVNPKYVHGSVIGAHGDSMIPL 237
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS--WAIGLSLSQ 355
S + G+ + ++ G + E+ KE+ E V SA+E++KL G S +A + +
Sbjct: 238 VSRSTVYGIPILQFVEQ-GYIT-MEDIKEIEERTVTSAFEILKLYGSGSSYFAPATAAIE 295
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+ + L + V S YL+G++G +++ P V+G +GV V LT E +
Sbjct: 296 MASSYLNDKKCVFPCSCYLEGQYG-HRDIYCGTPAVIGANGVEKVFELKLTPEEQDKYDA 354
Query: 536 SATLMAKVQADIK 574
S + +++A IK
Sbjct: 355 SIKEIKRLEALIK 367
>UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;
Candidatus Methanoregula boonei 6A8|Rep: L-lactate
dehydrogenase precursor - Methanoregula boonei (strain
6A8)
Length = 332
Score = 101 bits (242), Expect = 1e-20
Identities = 66/195 (33%), Positives = 107/195 (54%), Gaps = 1/195 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T V K SGL ++V G GT+LDS R + L++ + + H IIGEHGDS VP+
Sbjct: 126 DVMTCVALKYSGLKPNQVFGLGTHLDSMRLKSLIASYFKVHVSEVHTRIIGEHGDSMVPL 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS I G+++S+L ++ + V S ++IK KG T + G +++ LV
Sbjct: 186 WSATTIGGIKISNLPAFAHLPV-----QDFIQSVKTSGEQIIKNKGSTVYGPGEAIATLV 240
Query: 362 RAILYNANSVHAVSTYLKGE-HGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+ IL + N + VS Y+K E HGI V + +P + +G V + + E+E+ R+S
Sbjct: 241 KTILGDENRILTVSAYVKSEVHGIG-GVCIGVPARINKNGAFPVTIR-IDESEVIAYRES 298
Query: 539 ATLMAKVQADIKVLI 583
+ K++A I +I
Sbjct: 299 ---VEKIRATIHQII 310
>UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2;
Phaeosphaeria nodorum|Rep: L-lactate dehydrogenase -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 326
Score = 99 bits (238), Expect = 5e-20
Identities = 61/180 (33%), Positives = 99/180 (55%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DIL Y +SGLP+++V+G+GT+LDSAR R +L+ + G++ +S Y++GEHGDS
Sbjct: 125 DILVYFARMMSGLPENQVLGTGTSLDSARLRGVLAGKAGVSPSSIDAYVLGEHGDSQFVA 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS A + + L +G + E +E+ +A +I KG TS+ IG + +
Sbjct: 185 WSS---ASIGTTPLRLALGDELTDEFKEEVAMKTRGAAGAIIAAKGCTSYGIGNVAASIC 241
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
R IL+++ +V +S + + E G LS+P VLG G+ + L +E +L A
Sbjct: 242 RHILFDSRTVRPLS-FFQPELG----CCLSMPAVLGRRGILKAMPIELDASEKQELETCA 296
>UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28;
Bacteroidetes|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 313
Score = 99.1 bits (236), Expect = 8e-20
Identities = 61/193 (31%), Positives = 101/193 (52%), Gaps = 2/193 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +TY+ K GLPK+RVIG G LDS+RF+Y LS+ LG G +IG HGD+++
Sbjct: 124 DTMTYLALKSLGLPKNRVIGMGGALDSSRFKYFLSQALGCNANEVEGMVIGGHGDTTM-- 181
Query: 182 WSGVNIAGVRLSDL-NKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSW-AIGLSLSQ 355
I RL+ + + T E E+ + + KL G ++W A G + +
Sbjct: 182 -----IPLARLATYKGQPVSTLLSEEKLNEVVASTMVGGATLTKLLGTSAWYAPGAAGAY 236
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+V +I++N + S L+GE+G + ++ + +P +LG +G+ ++ L E A+
Sbjct: 237 VVESIIHNQKKMVPCSVMLEGEYG-ESDLCIGVPVILGKNGIEKIVELELNADEKAKFAA 295
Query: 536 SATLMAKVQADIK 574
SA + K A +K
Sbjct: 296 SAAAVHKTNAALK 308
>UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1;
Lactobacillus sakei subsp. sakei 23K|Rep: Putative
malate dehydrogenase - Lactobacillus sakei subsp. sakei
(strain 23K)
Length = 301
Score = 98.3 bits (234), Expect = 1e-19
Identities = 60/192 (31%), Positives = 94/192 (48%), Gaps = 2/192 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T ++G PK RV+G+GT LD+AR + + L +A S GY++GEHG+S
Sbjct: 124 DVITQYLQALTGFPKERVLGTGTTLDTARMQVAVGHYLNVAPNSVQGYVLGEHGNSQFVA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WSGV++ G + + T PE + + A+E++ KGYTS+ I +
Sbjct: 184 WSGVHVGG-------QPLATQLSPEQLAQFEVDARQGAWEILSGKGYTSYGIANQAAHCA 236
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEV--FLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
AIL N V VS + DE V ++ P ++G +GV LT E + +
Sbjct: 237 AAILQNTRQVLPVSNF-------DETVQCYVGHPAMVGAAGVLQDYPSQLTTAEQQKWQT 289
Query: 536 SATLMAKVQADI 571
S + + A I
Sbjct: 290 SIDTIKHMYAAI 301
>UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: Malate/L-lactate
dehydrogenase - Cenarchaeum symbiosum
Length = 302
Score = 97.9 bits (233), Expect = 2e-19
Identities = 60/172 (34%), Positives = 90/172 (52%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +TY+ +K SG K+RV G G LD +RFR + E G + S ++GEHG++ +P+
Sbjct: 121 DPITYIAYKTSGFEKNRVFGMGGMLDLSRFRQFIHEATGYSRDSIRALVMGEHGENMLPL 180
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
++G+ L L E EL K A +VI+LKG T A G S+S +V
Sbjct: 181 PRFSTVSGIPLLSL-------ISAEKAAELVRDTKKVAAKVIELKGATVHAPGNSISAMV 233
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
+I+ + V VS YL+GE+G V + +P V+G GV ++ L E
Sbjct: 234 ESIVRDKKQVIPVSAYLEGEYG-HSGVTIGVPAVIGRKGVEKIVELDLDGAE 284
>UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Lactate/malate
dehydrogenase - Thermosinus carboxydivorans Nor1
Length = 303
Score = 97.5 bits (232), Expect = 2e-19
Identities = 63/194 (32%), Positives = 104/194 (53%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T + +++SGLP +RVIG GT LD+AR+R L+ Y++GEHG++ V +
Sbjct: 120 DVMTQLAYQVSGLPANRVIGMGTVLDTARYRSYLAVAFDADARDIDAYVVGEHGETMVCL 179
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
S + + GV L+ L D + E VV+++ +VI LKG T +A + ++
Sbjct: 180 TSQITVRGVPLTAL-----PGYDQAKLAPIIENVVQASSQVIALKGGTVFAPATAACAVL 234
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AI+ ++ +V V TY ++G V LSLP ++G G V+ LT E QL S
Sbjct: 235 EAIVRDSRAVLPVCTY-NPQYG----VALSLPTIVGRGGAGPVLPLALTAAEQEQLAASV 289
Query: 542 TLMAKVQADIKVLI 583
+ K +++ L+
Sbjct: 290 ANIKKYVKEMEQLL 303
>UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7;
Halobacteriaceae|Rep: Malate dehydrogenase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 304
Score = 97.5 bits (232), Expect = 2e-19
Identities = 59/172 (34%), Positives = 90/172 (52%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+L ++ + +VIG G LDSARFRY+LSE + G I+GEHGD+ VPV
Sbjct: 124 DLLNRHLYEAGDRSREQVIGFGGRLDSARFRYVLSEEFDAPVQNVEGTILGEHGDAQVPV 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S V + G + + D + +L E SA +VI+ KG T W ++ +V
Sbjct: 184 FSKVRVDGT-----DPEFSGDEKEQLLGDLQE----SAMDVIERKGATEWGPARGVAHMV 234
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
AIL++ V S L+GE G ++ F +P LG +GV +++ L + E
Sbjct: 235 EAILHDTGEVLPASVKLEGEFGHEDTAF-GVPVRLGSNGVEEIVEWDLDDYE 285
>UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=3;
Lactobacillales|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 304
Score = 97.1 bits (231), Expect = 3e-19
Identities = 62/188 (32%), Positives = 94/188 (50%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T + K +GLP ++V G+GT LD+AR + L + L I GY++GEHGDS
Sbjct: 124 DVITGIYQKATGLPANQVFGTGTYLDTARLKRALGDTLAIDPRGISGYMLGEHGDSQFAA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS VN G +L K + D ++ E + V K YT++AI + L
Sbjct: 184 WSTVNALGKNADELVKLYDINLD-----KVAEAARVGGFTVFAGKKYTNFAIAHAAVSLA 238
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+ +L NA VS Y + G ++S P ++G GV+ LT+ E L+KSA
Sbjct: 239 KLVLSNARREAIVSHYDERFEG-----YISTPAIIGRDGVTAEFDLQLTDEEKILLQKSA 293
Query: 542 TLMAKVQA 565
+A+ A
Sbjct: 294 NAIAEKTA 301
>UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep: Malate/lactate
dehydrogenase - Leptospirillum sp. Group II UBA
Length = 320
Score = 97.1 bits (231), Expect = 3e-19
Identities = 57/181 (31%), Positives = 99/181 (54%), Gaps = 2/181 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ Y+ WK++G P+ RVIG G LDS+RF Y +SE + ++ ++G HGD VP+
Sbjct: 127 DLMAYILWKVTGFPRERVIGMGGALDSSRFAYFVSEVTNTSVSNIQTMVMGGHGDDMVPL 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS--WAIGLSLSQ 355
IAGV L KK DP+ ++L E+++L +S +A ++
Sbjct: 187 LEFSTIAGVSL----KKA---LDPDVLQKLVARTRDGGGEIVRLMKDSSAYFAPAAAIYS 239
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
++ +IL++ + V S YL+GE+G+ + VF +P +G+ G+ ++ PL+ E +
Sbjct: 240 MIESILHDRHRVIPSSVYLEGEYGV-KGVFSGVPVQIGNIGLEKIVLLPLSAEEEEAFHR 298
Query: 536 S 538
S
Sbjct: 299 S 299
>UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH -
Lactobacillus acidophilus
Length = 304
Score = 94.7 bits (225), Expect = 2e-18
Identities = 56/181 (30%), Positives = 98/181 (54%), Gaps = 1/181 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + + + +GL K++V+G+GT LD+AR + ++ E+LG + G+++GEHG S
Sbjct: 124 DAVAQILQETTGLSKNQVLGTGTFLDTARMQRIIGEKLGQDPKNVEGWVLGEHGSSQFIA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPEN-WKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS V + N KI EN ++L+++ K+++ V KGYTS+AI +L
Sbjct: 184 WSTVRV--------NNKIAIQLFSENEQRKLNKVPNKNSFVVANGKGYTSYAIATCAVRL 235
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
++AI +A+ VS Y + + ++ P ++G G+ VI LT E +L+ +
Sbjct: 236 IQAIFSDAHLYAPVSVY-----NPEYKTYIGYPAIIGRDGIEQVIELKLTSNEREKLQAA 290
Query: 539 A 541
A
Sbjct: 291 A 291
>UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 303
Score = 94.7 bits (225), Expect = 2e-18
Identities = 60/194 (30%), Positives = 106/194 (54%), Gaps = 3/194 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTS-CHGYIIGEHGDSSVP 178
D+LTY K +G + +VIG ++LD++RFRY +SE L + +S + ++GEHGDS VP
Sbjct: 121 DVLTYFFQKTTGFSRFKVIGIASSLDTSRFRYYISETLSVPQSSVSNALVLGEHGDSMVP 180
Query: 179 VWSGVNIAGVRLSDL--NKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLS 352
++SGV++ L + ++ TD+ W+ L +S + + K ++
Sbjct: 181 IFSGVSVGDNPLFSMIDSRDTITDNVRNYWRTLRNFKSRSQFGIAK-----------NVF 229
Query: 353 QLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLR 532
+V AI S L GE+ + +V + +P ++ +GVS++ + L +TE + L+
Sbjct: 230 DVVDAIRNKKEISIPASVVLDGEYD-EHDVAMGIPVIINQNGVSEIQKIKLDDTESSSLK 288
Query: 533 KSATLMAKVQADIK 574
KSA K+++DIK
Sbjct: 289 KSA---EKIRSDIK 299
>UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular
organisms|Rep: Malate dehydrogenase - Dehalococcoides
sp. (strain CBDB1)
Length = 307
Score = 94.3 bits (224), Expect = 2e-18
Identities = 63/189 (33%), Positives = 96/189 (50%), Gaps = 2/189 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +TY+ WK+SGLP+ RV+G LD R ++ LG+ ++ ++GEHG S V +
Sbjct: 122 DTMTYLAWKLSGLPRKRVVGLSGVLDGGRLATFVARELGVNPSAVSPCVMGEHGGSMVVM 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIK-LK-GYTSWAIGLSLSQ 355
+ G LS+L PE EL + V E++ LK G +A S++
Sbjct: 182 SRFTLVNGKPLSEL-------VSPEKADELAKRAVNGGAEIVAFLKTGSAFYAPSASVAA 234
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+V AI + V + L GE+G+ + L +P LG G+ ++I PL E A+L+
Sbjct: 235 MVEAIFLGSGKVMNCAAVLDGEYGL-RNIVLGVPVKLGKGGIKEIITLPLDGQENARLQA 293
Query: 536 SATLMAKVQ 562
SA M KVQ
Sbjct: 294 SAE-MVKVQ 301
>UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3;
Eimeriorina|Rep: Lactate dehydrogenase - Eimeria tenella
Length = 331
Score = 93.5 bits (222), Expect = 4e-18
Identities = 60/181 (33%), Positives = 94/181 (51%), Gaps = 2/181 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ + +GLP RV G LDSARFR LL++RLG++ ++G HGD+ VP+
Sbjct: 135 DVMVAALREAAGLPAARVCGMAGVLDSARFRRLLADRLGVSPRDVQAMVLGVHGDNMVPL 194
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS--WAIGLSLSQ 355
+ GV L +L ++ G S+ E +E+ + ++++L G S +A G +
Sbjct: 195 SRFATVNGVPLGELARQ-GWISEAE-IREVERQTRAAGGDIVRLLGQGSAYFAPGAAAVA 252
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+ A L + V S YL+G +G+ L +PCV+G GV VI PL E L+
Sbjct: 253 MAEAYLKDQKRVFVCSCYLEGPYGVRGHC-LGVPCVVGAGGVERVIELPLDAREAQLLQA 311
Query: 536 S 538
S
Sbjct: 312 S 312
>UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2;
Toxoplasma gondii|Rep: Mitochondrial
malate-dehydrogenase - Toxoplasma gondii
Length = 470
Score = 93.5 bits (222), Expect = 4e-18
Identities = 55/181 (30%), Positives = 92/181 (50%), Gaps = 2/181 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ Y+ + GLP H+V G LDSAR R LSERL ++ H ++G HGD+ VP+
Sbjct: 278 DVMVYILREKCGLPPHKVCGMAGVLDSARLRTFLSERLNVSVDDIHALVMGGHGDTMVPL 337
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
+ G+ L +L K+G S E ++ + E++ L G +A +
Sbjct: 338 PRFTTVGGIPLPEL-VKMGMISQQE-VDDIVQRTRNGGGEIVSLLKTGSAFFAPAAAGVL 395
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+ A L + V + YL GE+G+ +++++ +PCV+G GV ++ LT E +
Sbjct: 396 MAEAYLKDRKRVLPCAAYLNGEYGV-KDMYVGVPCVIGAGGVEKIVELDLTPEEKKMFER 454
Query: 536 S 538
S
Sbjct: 455 S 455
>UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=2;
Lactobacillus plantarum|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus plantarum
Length = 319
Score = 92.7 bits (220), Expect = 7e-18
Identities = 62/194 (31%), Positives = 93/194 (47%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +T+ + +GL + +V G+GT LD+AR + +++E + GY+ GEHG+S
Sbjct: 125 DAITHYFQRATGLSRQQVFGTGTFLDTARMQKVVAEAFDCDPKNISGYVYGEHGESQFSA 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G+ ++ L K D D L + V KGYTS+AI +L
Sbjct: 185 WSTVQVNGIPITSLVDKYHLDLD-----ALEAAARHGGWAVHSGKGYTSFAIATCAVKLS 239
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
A+ NA VS Y + E ++ P ++G GV V LT E A+ R SA
Sbjct: 240 EAVFANARLACPVSAYSE-----TFETYVGQPAIIGKDGVESVTTLALTADEQAKFRNSA 294
Query: 542 -TLMAKVQADIKVL 580
T++ K A VL
Sbjct: 295 DTIIEKFHAFDDVL 308
>UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=3;
Streptococcus thermophilus|Rep: L-2-hydroxyisocaproate
dehydrogenase - Streptococcus thermophilus (strain CNRZ
1066)
Length = 316
Score = 90.6 bits (215), Expect = 3e-17
Identities = 63/194 (32%), Positives = 97/194 (50%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +T + + +G PK RVIG+GT LD+AR + + E L + S GY +GEHG+S
Sbjct: 126 DAVTALYQEFTGWPKERVIGTGTLLDTARMKTAVGEVLEVNPKSVSGYNLGEHGNSQFTA 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G ++ L + E + L +K ++V KGYTS+ I + +LV
Sbjct: 186 WSQVKVKGQDITALTSE-------EERQNLFRASMKGGHKVFYGKGYTSYGIASAALRLV 238
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
IL +A VS+Y + + +L P +LG GV + L+ E L+ SA
Sbjct: 239 AIILSDAQEEVTVSSYQE-----IYQTYLGYPVILGRQGVEAPVHLTLSAEEKHLLQGSA 293
Query: 542 TLMA-KVQADIKVL 580
L+ +VQ + L
Sbjct: 294 DLIRNRVQEAVAFL 307
>UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:
Lactate dehydrogenase - Vibrio parahaemolyticus
Length = 317
Score = 90.2 bits (214), Expect = 4e-17
Identities = 58/179 (32%), Positives = 92/179 (51%), Gaps = 3/179 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+ + +G ++VI SG +D+AR +++ R+ + + GY++GEHG
Sbjct: 123 DIVAHFITTNTGFEPNKVISSGCVIDTARLMSIVANRVDLDPKNIFGYVLGEHGSHCFTP 182
Query: 182 WSGVNIAGVRLS---DLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLS 352
S ++IAG D + D+D EL E V ++ YE+ + K T I S+
Sbjct: 183 KSLISIAGQPADYYCDTHNIERIDAD-----ELLEAVKQAGYEIFRRKHNTVHGIAASVF 237
Query: 353 QLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQL 529
++++AI N SV V T + G++G+ V LSLP V+G G V+ P TE EL L
Sbjct: 238 RIIQAIKINERSVLPVGTMMSGQYGV-SGVVLSLPTVVGKKGAESVLTHPFTEEELETL 295
>UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17;
Apicomplexa|Rep: L-lactate dehydrogenase - Plasmodium
falciparum (isolate CDC / Honduras)
Length = 316
Score = 90.2 bits (214), Expect = 4e-17
Identities = 50/189 (26%), Positives = 102/189 (53%), Gaps = 1/189 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ + + SG+PK+++IG G LD++R +Y +S++L + + +I+G HG+ V +
Sbjct: 130 DVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLL 189
Query: 182 WSGVNIAGVRLSD-LNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
+ + G+ L + +N K+ +D++ E + + V +A E++ L A ++ ++
Sbjct: 190 KRYITVGGIPLQEFINNKLISDAELE---AIFDRTVNTALEIVNLHASPYVAPAAAIIEM 246
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+ L + V ST L+G++G ++F P VLG +GV VI L E A+ ++
Sbjct: 247 AESYLKDLKKVLICSTLLEGQYG-HSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEA 305
Query: 539 ATLMAKVQA 565
+++A
Sbjct: 306 IAETKRMKA 314
>UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5;
Methanococcus|Rep: Malate dehydrogenase - Methanococcus
maripaludis
Length = 314
Score = 89.8 bits (213), Expect = 5e-17
Identities = 53/184 (28%), Positives = 97/184 (52%), Gaps = 1/184 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TY SG K++V G GT+LDS RF+ +++ + I+GEHGDS VPV
Sbjct: 126 DLMTYKALIESGYEKNQVFGLGTHLDSMRFKVAVAKHFEVHLDDVRTRIVGEHGDSMVPV 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
S + G+ + L K + P ++++ E + E+I LK + + ++ +V
Sbjct: 186 ISATAVGGIPIKRLPK---YEDFP--YEKILERIKGYGQEIINLKNGSEYGPASAIVNIV 240
Query: 362 RAILYNANSVHAVSTYLKGE-HGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
R I ++ + +STY++ E GI+ + +P +G +G+ +VI + + E+ +KS
Sbjct: 241 RCIAHDEKRLLTLSTYIEDEIEGIEGGCCIGVPVKVGKNGIEEVIHIKMEDDEIEGFKKS 300
Query: 539 ATLM 550
L+
Sbjct: 301 FELV 304
>UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase;
n=15; Lactobacillales|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus confusus
Length = 310
Score = 89.4 bits (212), Expect = 6e-17
Identities = 54/179 (30%), Positives = 90/179 (50%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T + ++G P H+VIG+GT LD+AR + + E + S GY +GEHG+S
Sbjct: 127 DVITALFQHVTGFPAHKVIGTGTLLDTARMQRAVGEAFDLDPRSVSGYNLGEHGNSQFVA 186
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G + L D+ + + E K + V+ KGYTS+ + S ++
Sbjct: 187 WSTVRVMGQPIVTL-----ADAGDIDLAAIEEEARKGGFTVLNGKGYTSYGVATSAIRIA 241
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+A++ +A++ VS D ++LS P ++G GV LT E +L +S
Sbjct: 242 KAVMADAHAELVVS-----NRRDDMGMYLSYPAIIGRDGVLAETTLDLTTDEQEKLLQS 295
>UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=2;
Desulfitobacterium hafniense|Rep: Malate dehydrogenase,
NAD-dependent - Desulfitobacterium hafniense (strain
DCB-2)
Length = 320
Score = 89.0 bits (211), Expect = 9e-17
Identities = 52/181 (28%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+TYV +K SG ++R+IG LDSARFRY ++ L ++ G+++G HGD VP+
Sbjct: 124 DIMTYVAFKESGFKRNRIIGQSGVLDSARFRYFVASELKVSAEDVTGFVLGVHGDDMVPL 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS--WAIGLSLSQ 355
++ G+ + L + + ++ E ++ E++ L G S +A +L++
Sbjct: 184 VRYCSVHGIPIQQLLPEAEIE-------KIMERTRQAGSEIVNLLGNGSAYYAPAAALTE 236
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
++ +IL + + V +L+GE G +++ L++P V+G GV ++ L E + +
Sbjct: 237 MIESILLDKHRVMPCIVHLEGELGY-QDLVLNVPAVIGRQGVEKILPIDLLPEEEDLIER 295
Query: 536 S 538
S
Sbjct: 296 S 296
>UniRef50_O26290 Cluster: Malate dehydrogenase; n=2;
Methanobacteriaceae|Rep: Malate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 325
Score = 87.4 bits (207), Expect = 3e-16
Identities = 49/181 (27%), Positives = 89/181 (49%), Gaps = 1/181 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TYV + SG RV G G +LDS R + ++ + + H +IG+HG VP+
Sbjct: 125 DVMTYVALRYSGFHPSRVFGLGNHLDSLRLKNYMARHFNVHVSEVHTRVIGQHGPYMVPL 184
Query: 182 WSGVNIAGVRLSDLNKK-IGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
S +I G+ + ++ + + K+ + V+ + +I KG T + ++S +
Sbjct: 185 ISSTSIGGIPIEHYARRDYFSGYKKFDLKKTIDKVIHAGSNIISRKGATEYGPAFAISNI 244
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
V IL + + VST ++GE +V L +P LG +G+ V+ + E R++
Sbjct: 245 VTTILNDERRILTVSTLMEGEIDGIRDVCLGVPVKLGKNGIEGVVPVLMDRDEREAFREA 304
Query: 539 A 541
A
Sbjct: 305 A 305
>UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococcus
saprophyticus subsp. saprophyticus ATCC 15305|Rep:
Lactate dehydrogenase - Staphylococcus saprophyticus
subsp. saprophyticus (strain ATCC 15305 /DSM 20229)
Length = 310
Score = 86.6 bits (205), Expect = 5e-16
Identities = 49/179 (27%), Positives = 99/179 (55%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + Y +I P H++IG+GT L+++RF+ ++++ I + ++IGEHG ++PV
Sbjct: 124 DSMVYFANQID-YPAHKIIGTGTALETSRFKTIIADHYQIDPNNVEAFVIGEHGQHAIPV 182
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V+I G+ LS+ +D + + ++ + + +V KG+T+ AI S L+
Sbjct: 183 WSKVHIHGMELSEFEAL--SDRPAIDKSHISSIINEVSMDVFYQKGWTNAAISKVTSFLI 240
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
++I + ++ + T L E+G+++ F SLP ++ G+ L + E +L+++
Sbjct: 241 QSIALDQRTITPL-TSLSSEYGLEDGAF-SLPTLIDKKGIVQRFAITLDKEEERELKEA 297
>UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium
(Plasmodium)|Rep: Lactate dehydrogenase - Plasmodium
vivax
Length = 299
Score = 86.6 bits (205), Expect = 5e-16
Identities = 50/174 (28%), Positives = 92/174 (52%), Gaps = 2/174 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ + ++ SG+PK+++IG G LD++R +Y +S++L + + I+G HG+ V +
Sbjct: 123 DVMVQLLFEHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNALIVGAHGNKMVLL 182
Query: 182 WSGVNIAGVRLSDL--NKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQ 355
+ + G+ L + NKKI TD + E + + V +A E++ L A ++ +
Sbjct: 183 KRYITVGGIPLQEFINNKKI-TDEEVEG---IFDRTVNTALEIVNLLASPYVAPAAAIIE 238
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
+ + L + V ST L+G++G +F P V+G +GV VI L E
Sbjct: 239 MAESYLKDIKKVLVCSTLLEGQYG-HSNIFGGTPLVIGGTGVEQVIELQLNAEE 291
>UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=1;
Sulfurovum sp. NBC37-1|Rep: Malate dehydrogenase,
NAD-dependent - Sulfurovum sp. (strain NBC37-1)
Length = 320
Score = 85.0 bits (201), Expect = 1e-15
Identities = 56/195 (28%), Positives = 93/195 (47%), Gaps = 2/195 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++TYV K +G P+ RV+G LD+AR + + E+L ++G HGD+ VP+
Sbjct: 126 DVMTYVALKETGFPRQRVLGMAGILDAARMAHFIYEKLEYGAGQIRATVMGGHGDTMVPL 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS--WAIGLSLSQ 355
+AGV + DL D E E+ E++ L G S +A S +
Sbjct: 186 PKFTTVAGVPIEDL-------LDSEEIGEIVRKTRNGGAEIVNLLGDGSAYYAPAKSTTV 238
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+V AIL + N +H+ + LK ++G ++ +P ++G G VI L + + +
Sbjct: 239 MVEAILKDTNQIHSCAIMLKNDYGY-SDIVSGVPVMIGAGGAEKVINMTLKPLQQTRFKN 297
Query: 536 SATLMAKVQADIKVL 580
S +A VQ + L
Sbjct: 298 S---VASVQEMVDTL 309
>UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
agalactiae
Length = 323
Score = 85.0 bits (201), Expect = 1e-15
Identities = 51/191 (26%), Positives = 99/191 (51%), Gaps = 1/191 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ S +P +RVI +GTNL++ R + +L+ + + + ++GEHG +++
Sbjct: 125 DVMAAAVHYGSKIPANRVISAGTNLETGRLKKMLAAKFNTSPDAIRASVLGEHGATAMIA 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + L L + E+++E+ + V+ A+ + KG T + I SL ++
Sbjct: 185 WSTVKVGETTLEGLVE--SGKITKEDYEEVLKQVIAEAFYIWSRKGNTQFGIATSLFEIT 242
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQP-LTETELAQLRKS 538
+AIL N +V + + E +++S+P ++G +G + +P LT+ E A+ S
Sbjct: 243 KAILDNRRTVMNLGVKIP-EGYKHAGIYVSIPVIIGENGYEYLPFKPSLTKEEWAKFEAS 301
Query: 539 ATLMAKVQADI 571
+AKV +I
Sbjct: 302 TEAVAKVHTEI 312
>UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobus
fulgidus|Rep: Malate dehydrogenase - Archaeoglobus
fulgidus
Length = 294
Score = 85.0 bits (201), Expect = 1e-15
Identities = 62/185 (33%), Positives = 99/185 (53%), Gaps = 2/185 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERL--GIATTSCHGYIIGEHGDSSV 175
D++TY+ WK SG P++ V G G LDS R L ERL A +IIGEHGDS
Sbjct: 122 DVMTYIMWKESGKPRNEVFGMGNQLDSQR----LKERLYNAGARNIRRAWIIGEHGDSMF 177
Query: 176 PVWSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQ 355
S L+D + ++ +W+ + V A EVIK KG T + +++ +
Sbjct: 178 VAKS--------LADFDGEV-------DWEAVENDVRFVAAEVIKRKGATIFGPAVAIYR 222
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+V+A++ + + S L+GE+GI E V + +P LG +G ++V L++ E+ +LR
Sbjct: 223 MVKAVVEDTGEIIPTSMILQGEYGI-ENVAVGVPAKLGKNG-AEVADIKLSDEEIEKLRN 280
Query: 536 SATLM 550
SA ++
Sbjct: 281 SAKIL 285
>UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex
aeolicus|Rep: Malate dehydrogenase 2 - Aquifex aeolicus
Length = 334
Score = 85.0 bits (201), Expect = 1e-15
Identities = 66/198 (33%), Positives = 96/198 (48%), Gaps = 5/198 (2%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D LTY T K++G RVIG LDSARF+ + E++GI+ ++G HGD VPV
Sbjct: 141 DTLTYATIKLTGFEPRRVIGMAGVLDSARFKNFVKEKIGISNADIRTLVLGTHGDLMVPV 200
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS-WAIGLSLSQL 358
S I + ++ D EL E K +++ L G ++ +A S+ +
Sbjct: 201 TSHSFIGDKPIEEVFSASEID-------ELIEKTRKGGAQIVSLMGTSAYYAPAASVVIM 253
Query: 359 VRAILYNANSVHAVSTYLKGE---HGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQL 529
V +I+ + V S Y++GE H E V + LP VLG GV D L+ E +L
Sbjct: 254 VESIINDRKRVMPCSVYVEGEAAKHYEIEGVCIGLPVVLGKKGVEDFELVNLSGYEKREL 313
Query: 530 RKSA-TLMAKVQADIKVL 580
+SA TL V K+L
Sbjct: 314 LRSAKTLKEMVSLADKLL 331
>UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10444.1 - Gibberella zeae PH-1
Length = 309
Score = 84.6 bits (200), Expect = 2e-15
Identities = 52/184 (28%), Positives = 96/184 (52%), Gaps = 1/184 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT + ++SGLP+ +V G+GT LD+ R R +++ R ++ + +++G HG+ V V
Sbjct: 125 DLLTSLAKQMSGLPESQVFGTGTALDTYRLRGMIASRALVSPYTVDAFVVGRHGEEQVVV 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVK-SAYEVIKLKGYTSWAIGLSLSQL 358
WS I V + D+ D + E++ K + ++I KG + I ++ L
Sbjct: 185 WSSATIGAVPIQDVKMLDSID------RSRIELICKHRSNQIILGKGSAPFGIASVVANL 238
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+++ + + ++ VS Y + EHG LSLP V+G G+ + + E E A ++ S
Sbjct: 239 CCSVILDKHEMYPVS-YFQEEHG----CCLSLPAVIGRKGILNSVPLATNENESAAVKLS 293
Query: 539 ATLM 550
L+
Sbjct: 294 GKLL 297
>UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Malate dehydrogenase -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 311
Score = 83.0 bits (196), Expect = 6e-15
Identities = 51/181 (28%), Positives = 91/181 (50%), Gaps = 2/181 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LTY W+ G + RV G LDSAR ++ G++ ++G HGD+ +P+
Sbjct: 125 DVLTYHAWRHCGWDRARVFGQAGVLDSARMASFIAGETGLSVKDISAMVLGGHGDTMLPL 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSW--AIGLSLSQ 355
I+G+ L+ D + +++ E +E+++L+ +S A +++
Sbjct: 185 IRYTTISGIPLTHF-------LDQQVIEKIIERTRHGGFEILRLRQTSSAYDAPAAAIAG 237
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+V AI +N + L+GE+G + EV + +P VLG G+ ++ PLTE E Q +
Sbjct: 238 MVDAIRHNRKRILPCVAILQGEYG-ENEVAMGVPSVLGGDGLERIVELPLTEEEQEQFKH 296
Query: 536 S 538
S
Sbjct: 297 S 297
>UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6;
Plasmodium|Rep: Oxidoreductase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 334
Score = 82.6 bits (195), Expect = 7e-15
Identities = 51/174 (29%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + V + + +P H++ G L SAR R+ L+E+L + G++IG HGD VP+
Sbjct: 133 DCMAKVLQEHANIPPHKICGMAGVLHSARLRHNLAEKLRVNPGDVQGFVIGAHGDKMVPL 192
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
+ G+ LSD KK G ++ E ++ E + +E+++L +G +A L++ +
Sbjct: 193 PRYCCVNGIPLSDFTKK-GAITEKE-INQIVEKTRNTGFELLELLPEGSVCFAPSLAIVE 250
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
++ A L + V S L G +G + VF +P V+G G+ +I L E
Sbjct: 251 IIEAYLKDLKRVLVCSVLLNGHYG-HKGVFAGIPVVIGGKGIEKIIELDLNTQE 303
>UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene
encodes predicted malate dehydrogenase; n=8;
Cryptosporidium|Rep: Lactate dehydrogenase, adjacent
gene encodes predicted malate dehydrogenase -
Cryptosporidium parvum Iowa II
Length = 337
Score = 82.6 bits (195), Expect = 7e-15
Identities = 50/180 (27%), Positives = 90/180 (50%), Gaps = 1/180 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ K+SGLP ++V G LDS+RFR +++ G+ + +IG HGD VPV
Sbjct: 141 DVMVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHGDGMVPV 200
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVV-KSAYEVIKLKGYTSWAIGLSLSQL 358
S V++ GV LS K+ + + H + K + +K G +A + ++
Sbjct: 201 TSSVSVGGVPLSSFIKQGLITQEQIDEIVCHTRIAWKEVADNLK-TGTAYFAPAAAAVKM 259
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
A L + +V S + +G+ + +++ +P ++G +GV D++ LT E L +S
Sbjct: 260 AEAYLKDKKAVVPCSAFCSNHYGV-KGIYMGVPTIIGKNGVEDILELDLTPLEQKLLGES 318
>UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4;
Thermoplasmatales|Rep: Malate dehydrogenase -
Thermoplasma volcanium
Length = 325
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/195 (28%), Positives = 100/195 (51%), Gaps = 4/195 (2%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+ Y KISG+ R++G G +LDS+RFR L++ L ++ + ++IG HGD VP
Sbjct: 129 DIMAYALQKISGVDPQRIMGLGGSLDSSRFRTFLAKELDVSVEDVNAFVIGGHGDDMVPF 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
++AG+ + L K D+ + + +V +K G +A G+S++ +V
Sbjct: 189 IRYSSVAGIPIEKLLPKEKIDAIVKRTRFGGGEIV----NYLK-AGSAYYAPGISITAMV 243
Query: 362 RAILYNANSVHAVSTYLKGEH----GIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQL 529
+++ + V + Y+ G+H GI+ + F+ +P +G GV ++ EL
Sbjct: 244 ESVIKDKKRVIPCAAYITGKHAEHYGINNK-FIGVPIKIGERGVEEIYDIDFLPEELELW 302
Query: 530 RKSATLMAKVQADIK 574
+KS +A V+A K
Sbjct: 303 KKS---VASVEASSK 314
>UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular
organisms|Rep: Malate dehydrogenase - Gloeobacter
violaceus
Length = 325
Score = 81.8 bits (193), Expect = 1e-14
Identities = 52/182 (28%), Positives = 88/182 (48%), Gaps = 2/182 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +++V W+ SGL RV+G LD+ARF ++ LG + ++G HGD VP+
Sbjct: 129 DAMSHVAWRASGLVPERVMGMAGVLDAARFETFIAWELGFSVRDIRAMVLGGHGDLMVPL 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
I+GV L+ L D+ L E E++ L +G +A + ++
Sbjct: 189 PRYTTISGVPLTQLLSSARIDA-------LIERTRTGGAEIVHLLKRGGAYYAPAAAAAR 241
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
++ +L + + V+ YL GE+G+ + + +P +L GV V+ L E A L +
Sbjct: 242 MIETLLGDERRLLPVAAYLSGEYGL-RNIHMGVPVILSRHGVERVVELTLETEEKAALYR 300
Query: 536 SA 541
SA
Sbjct: 301 SA 302
>UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular
organisms|Rep: Malate dehydrogenase - Silicibacter
pomeroyi
Length = 320
Score = 79.8 bits (188), Expect = 5e-14
Identities = 51/174 (29%), Positives = 86/174 (49%), Gaps = 2/174 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + + + SGLP ++V G LDSARFR+ L+E ++ +++G HGD+ VP
Sbjct: 124 DAMVWALQQFSGLPANKVCGMAGVLDSARFRHFLAEEFNVSMKDVTAFVLGGHGDTMVPS 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
+AG+ L DL K+G S E + + E++ L G +A S +
Sbjct: 184 VRYSTVAGIPLPDL-IKMGWTSQ-EKLDAIVQRTRDGGAEIVGLLKTGSAYYAPATSAIE 241
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
+ A L + V + Y GE G+ + +++ +P V+G G+ +I LT+ E
Sbjct: 242 MAEAYLKDQKRVLPCAAYCNGELGV-KGMYVGVPTVIGAGGIERIIDVSLTKEE 294
>UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;
Ignicoccus hospitalis KIN4/I|Rep: malate dehydrogenase
(NAD) - Ignicoccus hospitalis KIN4/I
Length = 311
Score = 79.4 bits (187), Expect = 7e-14
Identities = 56/186 (30%), Positives = 96/186 (51%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T + + G K VIG+GT+LD+ RFR +SE L + GY++GEHG+ +
Sbjct: 127 DVMTMILSDVIG-NKGTVIGTGTSLDTYRFRSAVSELLNEPIAAIDGYVVGEHGEEAFVA 185
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + GV + + K+ G D + + E V + A +I +G T W + ++V
Sbjct: 186 WSTVTVKGVPIDEYIKEKGLDL---SRSRIEEYVKEVAATIIAKQGATIWGPAATFQEIV 242
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+ L N + VS ++ G+ V +S+P + SG + Q L E E +L+++A
Sbjct: 243 VSHLANEGRIIPVSV-VQEVPGVG-RVAVSVPTKI--SGRLVPLPQLLNEEERERLKRAA 298
Query: 542 TLMAKV 559
+ +V
Sbjct: 299 EAIKRV 304
>UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2;
Methanomicrobiales|Rep: Lactate/malate dehydrogenase -
Methanospirillum hungatei (strain JF-1 / DSM 864)
Length = 290
Score = 79.4 bits (187), Expect = 7e-14
Identities = 57/184 (30%), Positives = 92/184 (50%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DILTY WK G+ K+R+IG G LDSARF+Y LS R + G I+GEHG+ VP+
Sbjct: 116 DILTYYLWKSLGILKNRIIGFGGQLDSARFQYELSLR----SIRDDGIILGEHGEHQVPI 171
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S K G D + ++ + ++ E+IK KG T +A + L+
Sbjct: 172 FS--------------KTGLDVEIPIRDDILVTLRNASMEIIKGKGATEYAPVYHIWHLI 217
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+I+ +A + S L+GE+ + L +P ++G G+ + L E + +A
Sbjct: 218 ESIITDAKTNLICSAILEGEYDV-TGCSLGVPVIIGREGILSIEEWDLDLWEKEHFQDAA 276
Query: 542 TLMA 553
T ++
Sbjct: 277 TFVS 280
>UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4;
Pezizomycotina|Rep: L-lactate dehydrogenase -
Aspergillus clavatus
Length = 312
Score = 77.8 bits (183), Expect = 2e-13
Identities = 55/181 (30%), Positives = 89/181 (49%), Gaps = 1/181 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+LT V ++SGLP +V+GSGT L+S R R L+++ G+A S Y++G HG
Sbjct: 129 DLLTTVAQQLSGLPPTQVLGSGTLLESVRLRGLVAKTTGVAPDSVDLYVLGVHGIGETVA 188
Query: 182 WSGVNIAGVRLSDLNKKIGTDS-DPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQL 358
WS + G+ L+ + I +S DP +L + + +I KG G +S++
Sbjct: 189 WSTATVGGLSLA---RAIPPNSLDP---IQLARECRQISQTIIHAKGAIPLGTGAIISKV 242
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+IL + ++ +S Y + D SLP ++G G+ IR E + KS
Sbjct: 243 CSSILRDQRDIYPISHYQE-----DFGCCFSLPVIIGRKGILRTIRVAANAEEWDGITKS 297
Query: 539 A 541
A
Sbjct: 298 A 298
>UniRef50_P11386 Cluster: Malate dehydrogenase; n=6;
Sulfolobaceae|Rep: Malate dehydrogenase - Sulfolobus
acidocaldarius
Length = 306
Score = 77.4 bits (182), Expect = 3e-13
Identities = 51/179 (28%), Positives = 93/179 (51%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ V K SG I +G +++ R R ++++L I GY+ GEHG++++ +
Sbjct: 123 DMMASVFMKYSG---ENTISTGNQVETMRMRSYIAKKLNIPAYEVGGYVGGEHGEAAMVL 179
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G S+ +G N E+ + V K A E+I++ G T+W G + +++
Sbjct: 180 WSTVTVKGKPFSE---SLGV-----NKAEVEDYVKKIAAEIIRVLGGTTWGPGADIEEVI 231
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
R++ N V +V+ K E DE + +S P V+G + V + L E + A+L ++
Sbjct: 232 RSVALNEGKVMSVAFPHKYE---DEIIHISEPVVVGRT-VGPALTSALDENDKARLSQA 286
>UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4;
Epsilonproteobacteria|Rep: Malate dehydrogenase -
Wolinella succinogenes
Length = 314
Score = 77.0 bits (181), Expect = 4e-13
Identities = 55/181 (30%), Positives = 88/181 (48%), Gaps = 2/181 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + Y K SGL +V+G LDSAR + E+LG + ++G HGD VP+
Sbjct: 120 DAMVYTAIKESGLSPLQVLGMAGILDSARMASFIFEKLGYGSDQIVASVMGGHGDDMVPL 179
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
N+AGV +++L +P+ +E+ + E++ KG +A S +
Sbjct: 180 PRYSNVAGVPITEL-------LEPQEIEEIIHRTRNAGAEIVGYLKKGSAYFAPAKSTAI 232
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
+V AIL N++ V S L+GE+G +V +P LG GV ++I L E + +
Sbjct: 233 MVEAILKNSHQVFPCSVLLQGEYGY-SDVVGGVPVKLGSRGVCEIIELELLHEERERFDQ 291
Query: 536 S 538
S
Sbjct: 292 S 292
>UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|Rep:
Malate dehydrogenase - Plasmodium falciparum
Length = 313
Score = 76.6 bits (180), Expect = 5e-13
Identities = 49/176 (27%), Positives = 93/176 (52%), Gaps = 4/176 (2%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+ V K S LP ++ G LD++R+ L++++L ++ + I+G HGD VP+
Sbjct: 122 DIMVNVFHKFSNLPHEKICGMAGILDTSRYCSLIADKLKVSAEDVNAVILGGHGDLMVPL 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKS---AYEVIKL-KGYTSWAIGLSL 349
++ GV LS+ KK + + E+ E++ K+ E+IKL K ++A ++
Sbjct: 182 QRYTSVNGVPLSEFVKK-----NMISQNEIQEIIQKTRNMGAEIIKLAKASAAFAPAAAI 236
Query: 350 SQLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
++++++ LYN N++ + YL G + +F+ + + G V PLT+ E
Sbjct: 237 TKMIKSYLYNENNLFTCAVYLNGHYNC-SNLFVGSTAKINNKGAHPV-EFPLTKEE 290
>UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1;
Methanoculleus marisnigri JR1|Rep: Lactate/malate
dehydrogenase - Methanoculleus marisnigri (strain ATCC
35101 / DSM 1498 / JR1)
Length = 288
Score = 76.6 bits (180), Expect = 5e-13
Identities = 56/186 (30%), Positives = 91/186 (48%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D Y WK+ G+ + R IG G+ LDSARF L E +GI + +++GEHGD VPV
Sbjct: 116 DANNYGLWKMMGIDRRRCIGFGSQLDSARFAGFLRE-VGIPGPA---WVLGEHGDRQVPV 171
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
+S K G+D D + + + ++ EVI+ KG T + ++ L+
Sbjct: 172 FS--------------KTGSDLDTGEREAILSRMRGASMEVIRGKGGTVFGPAYHIAMLI 217
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
RAIL++ V S L GE G+ L +P +G G+ + L E A++ ++
Sbjct: 218 RAILHDRREVLPCSCVLDGEFGL-SGCSLGVPARIGREGILGIEEWELDTWESAKMAEAG 276
Query: 542 TLMAKV 559
+ ++
Sbjct: 277 AFVREL 282
>UniRef50_Q8Y860 Cluster: Lmo1057 protein; n=11; Listeria|Rep:
Lmo1057 protein - Listeria monocytogenes
Length = 317
Score = 74.5 bits (175), Expect = 2e-12
Identities = 46/174 (26%), Positives = 90/174 (51%), Gaps = 2/174 (1%)
Frame = +2
Query: 26 KISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVWSGVNIAG 205
+ SGL +++I GT L ++ F+ +++ I+ + HGYIIG++ + +PVWS + G
Sbjct: 126 RFSGLSANQIITLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNAEDVIPVWSRAFLGG 185
Query: 206 VRLSDLNKKIGTDSDPENWKELHEMVVK-SAYEVIKLKGYT-SWAIGLSLSQLVRAILYN 379
+ + E+ + L +M+ K + G T ++ L++L IL +
Sbjct: 186 KPILSYLAEDQKRISAEDLQNLTKMITKIPDFPFENKDGCTFRFSTVTVLAELTEVILRD 245
Query: 380 ANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
V V +K +G++ VF+S+P V+G GV +++ L++ E +L++ A
Sbjct: 246 EARVITVGVEVKEAYGLENPVFISVPAVIGAEGVRELLELNLSDDEQKELKQIA 299
>UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: Enzyme with possible
activities of L-2- hydroxyisocaproate/malate/lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 301
Score = 72.5 bits (170), Expect = 8e-12
Identities = 50/183 (27%), Positives = 90/183 (49%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D +T + LPK ++IG+GT+LD+ R R +++ L + GY +GEHG+S
Sbjct: 124 DAVTSYWQYLLDLPKSQIIGTGTSLDTYRMRRAVADTLHVNVADVRGYNMGEHGESQFTA 183
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + +++ K D D +L + +++ + K YTS+ I +++
Sbjct: 184 WSTVRVNNEPIAEYAK---VDYD-----QLADDARAGGWKIYQAKHYTSYGIATIATEMT 235
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
+AI+ +A+ + + Y E GI + P ++G GV LT+ E A+ SA
Sbjct: 236 QAIISDAHRIFPCANY-DPEFGI----AIGHPAMIGKQGVIKTPTLKLTDEERAKYVHSA 290
Query: 542 TLM 550
++
Sbjct: 291 GII 293
>UniRef50_Q8VMZ6 Cluster: L-lactate dehydrogenase; n=1; Listeria
grayi|Rep: L-lactate dehydrogenase - Listeria grayi
(Listeria murrayi)
Length = 126
Score = 70.1 bits (164), Expect = 4e-11
Identities = 32/93 (34%), Positives = 57/93 (61%)
Frame = +2
Query: 290 SAYEVIKLKGYTSWAIGLSLSQLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLG 469
+AYE+I KG T + I +L+++ +AIL N N++ +S YL G +G+ +++++ P V+
Sbjct: 30 AAYEIINKKGATFYGIAAALARITQAILNNENAILPLSVYLDGHYGL-KDIYIGAPAVVN 88
Query: 470 HSGVSDVIRQPLTETELAQLRKSATLMAKVQAD 568
GV ++ L++TE Q+ SA + KV D
Sbjct: 89 RKGVRHIVEMKLSDTEQEQMNASAATLQKVLDD 121
>UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacter
fetus subsp. fetus 82-40|Rep: Malate dehydrogenase -
Campylobacter fetus subsp. fetus (strain 82-40)
Length = 306
Score = 66.1 bits (154), Expect = 7e-10
Identities = 34/110 (30%), Positives = 58/110 (52%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
DI+ YV +K SG +H+VIG LDSARFRY +S++LG+ C G +G H +S + +
Sbjct: 122 DIMVYVAFKESGFARHKVIGMAGELDSARFRYYMSQKLGLNVAQCFGKCVGMHNNSMICL 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSW 331
S + N+ I D + ++++ ++KL G +++
Sbjct: 182 ESSIKFK-------NQSICKDEFKKYFEDIKLNTKNGGSNIVKLMGTSAF 224
>UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter
hepaticus|Rep: Malate dehydrogenase - Helicobacter
hepaticus
Length = 315
Score = 64.1 bits (149), Expect = 3e-09
Identities = 53/192 (27%), Positives = 83/192 (43%), Gaps = 2/192 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + V + S K RVIG LDSAR Y LG Y+IG H D +P+
Sbjct: 125 DAMCLVAKQWSKFEKERVIGMAGILDSARLTYESKVMLGDFNKHIQSYVIGSHSDDMLPL 184
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQ 355
G +D+ P+ +EL + +++ KG +A + +
Sbjct: 185 LRHCLCEGKVFTDI-------FTPKMQEELIKETKGGGAKIVNYYQKGSAYFAPASGVIK 237
Query: 356 LVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRK 535
++ AI + S + +GE+GI ++++L LP LG GV ++ PL + E L
Sbjct: 238 ILEAISTLNEEILVCSVFTEGEYGI-KDIYLGLPIKLGKKGVEHIVELPLNQQEQEMLNI 296
Query: 536 SATLMAKVQADI 571
S T K Q +I
Sbjct: 297 S-TQGIKEQVEI 307
>UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1;
Streptomyces avermitilis|Rep: Putative lactate
dehydrogenase - Streptomyces avermitilis
Length = 303
Score = 61.7 bits (143), Expect = 1e-08
Identities = 30/68 (44%), Positives = 43/68 (63%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++T + + SG P RV G G+NLDSAR+R L+ L + T+ HG++IGEHGD +V
Sbjct: 123 DLMTRLFAETSGCP--RVYGIGSNLDSARYRLTLAHLLDVPATTVHGHVIGEHGDGAVVC 180
Query: 182 WSGVNIAG 205
S + G
Sbjct: 181 ASSTTVNG 188
>UniRef50_Q59G78 Cluster: Lactate dehydrogenase B variant; n=1; Homo
sapiens|Rep: Lactate dehydrogenase B variant - Homo
sapiens (Human)
Length = 129
Score = 60.9 bits (141), Expect = 3e-08
Identities = 26/46 (56%), Positives = 37/46 (80%)
Frame = +2
Query: 278 MVVKSAYEVIKLKGYTSWAIGLSLSQLVRAILYNANSVHAVSTYLK 415
++ SAYEVIKLKGYT+WAIGLS++ L+ ++L N + +H VST +K
Sbjct: 10 IIFLSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVK 55
>UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1;
Endoriftia persephone 'Hot96_1+Hot96_2'|Rep: Malate
dehydrogenase NAD-dependent - Endoriftia persephone
'Hot96_1+Hot96_2'
Length = 170
Score = 56.8 bits (131), Expect = 4e-07
Identities = 25/74 (33%), Positives = 42/74 (56%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D + Y K+SGLP R+IG LD+ARFR ++ G++ ++G HG + +PV
Sbjct: 50 DSIVYAFHKLSGLPAERIIGMAGALDTARFRTYIAMETGLSVKDVSCLVMGGHGPTMIPV 109
Query: 182 WSGVNIAGVRLSDL 223
++ G+ L++L
Sbjct: 110 TRTASVGGIPLTEL 123
>UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1;
Aspergillus niger|Rep: Catalytic activity: precursor -
Aspergillus niger
Length = 307
Score = 56.4 bits (130), Expect = 6e-07
Identities = 52/175 (29%), Positives = 79/175 (45%), Gaps = 3/175 (1%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIG-EHGDSSVP 178
D LT + I+GLP+ +VIG GT +DS R + +S LG GY++G +S V
Sbjct: 122 DTLTTLAQDIAGLPRKQVIGVGTCIDSLRLQDEVSRFLGTTMEETEGYVVGVRDSESQVV 181
Query: 179 VWSGVNIAGVRLS-DLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQ 355
WSG+ R + K+I + + + W L +V KG W IG
Sbjct: 182 GWSGLMTPQGRDGIAIQKRI--EIENKIWGRLKAIVAG--------KGGAPWGIGAVAGG 231
Query: 356 LVRAILY-NANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETE 517
+ A+L N +V VS + + D S P V+G GV ++ L ++E
Sbjct: 232 IAVAVLEDNKKTVWTVSCWRE-----DYRCCCSWPVVVGREGVVREVKLELGQSE 281
>UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4;
Bacteroidales|Rep: Malate dehydrogenase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 334
Score = 56.0 bits (129), Expect = 7e-07
Identities = 58/196 (29%), Positives = 91/196 (46%), Gaps = 6/196 (3%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIA---TTSCHGYIIGEHGDSS 172
DI VT SGL +V + LDS R + L++ GI T+ Y G HG+
Sbjct: 128 DITGLVTLIYSGLKPSQVT-TLAGLDSTRLQSELAKHFGIKQSLVTNTRTY--GGHGEQM 184
Query: 173 VPVWSGVNIAGVRLSDLNKKIGTDS-DPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSL 349
S + G L+DL IGTD E W EL + VVK +IKL+G +S+ +
Sbjct: 185 AVFASTAKVNGTPLTDL---IGTDKLTNEQWAELKQRVVKGGANIIKLRGRSSFQSPSYV 241
Query: 350 S-QLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVS-DVIRQPLTETELA 523
S +++RA + Y+ G E + +++ + GV I Q E E A
Sbjct: 242 SIEMIRAAMGGEAFRWPAGCYV-NVPGF-EHIMMAMETTITKDGVKYSDINQLGNEAERA 299
Query: 524 QLRKSATLMAKVQADI 571
L++S + +AK++ ++
Sbjct: 300 ALKESYSHLAKLRDEV 315
>UniRef50_Q1U8H4 Cluster: L-lactate dehydrogenase; n=2;
Lactobacillus reuteri|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri 100-23
Length = 307
Score = 52.8 bits (121), Expect = 7e-06
Identities = 46/189 (24%), Positives = 82/189 (43%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
+ +T V + GLP+ +VIG GT +++AR ++E +A + G++ G+H V
Sbjct: 122 EAITAVLQQKVGLPQKQVIGIGTVVETARLYRAIAEAAKVAAANVTGFVYGQHDGHQVFA 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLV 361
WS V + G L+ G D K + S + + GY A+ +++
Sbjct: 182 WSTVRVNGQPLTAAIN--GHHLDQSQLKIKANL---SNWYTLDGLGYNVSAVTAWTLRII 236
Query: 362 RAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKSA 541
AI + V+ Y ++S P ++G G+ +++ L E ++ KSA
Sbjct: 237 TAIFADEQLALPVAIYQP-----QYSTYISFPALIGRQGIGNLLLLKLYPLEEEEI-KSA 290
Query: 542 TLMAKVQAD 568
K Q D
Sbjct: 291 AATIKHQLD 299
>UniRef50_A2SNY0 Cluster: Malate/lactate dehydrogenases-like
protein; n=1; Methylibium petroleiphilum PM1|Rep:
Malate/lactate dehydrogenases-like protein - Methylibium
petroleiphilum (strain PM1)
Length = 432
Score = 52.8 bits (121), Expect = 7e-06
Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 3/191 (1%)
Frame = +2
Query: 8 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVWS 187
+T++ + +G P+ RV+G LDSARF L+ +G HG V
Sbjct: 247 MTHLAAQQTGFPEERVLGMAGVLDSARFCALVGLTGKARPQEVRAVALGSHGPEMV---- 302
Query: 188 GVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL--KGYTSWAIGLSLSQLV 361
+ ++ + D + I + D E K L E +S EV+KL KG ++ S +V
Sbjct: 303 -IPLSQAFVGD--RPIESMFDAETLKALVERARESGGEVVKLLQKGSAYFSPAESAVTMV 359
Query: 362 RAILYNANSVHAVSTYLKGEHG-IDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
RA++ ++ V A +G +G +D V LP L G+ +++ L E L+ +
Sbjct: 360 RAMVRDSGEVIAACVRSRGAYGAVDTRV--GLPVRLHRRGLKEIVPLTLRPAEQQALQDA 417
Query: 539 ATLMAKVQADI 571
A +A A++
Sbjct: 418 AARIAARIAEL 428
>UniRef50_A7GYI6 Cluster: Lactate/malate dehydrogenase, NAD binding
domain protein; n=2; Campylobacter|Rep: Lactate/malate
dehydrogenase, NAD binding domain protein -
Campylobacter curvus 525.92
Length = 297
Score = 50.4 bits (115), Expect = 4e-05
Identities = 47/194 (24%), Positives = 87/194 (44%), Gaps = 1/194 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D++ + + SG + RVIG LDSAR RY ++ I+ ++G H D +
Sbjct: 122 DVMVWTVLRYSGFDRSRVIGMAGELDSARCRYEIASLKDISAKDVSAKVLGAHNDKMI-- 179
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTS-WAIGLSLSQL 358
V +LN+ + P +++ + +++KL G ++ +A ++ ++
Sbjct: 180 --------VSAKNLNQNL----SPLELEKIKQETKTGGAKIVKLLGTSAYYAPAAAVVKM 227
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
AI N++ + A S L E V LS SG+ +++ L EL +L S
Sbjct: 228 CEAIKNNSDEILAASVILSDELACGRLVKLS------KSGLKEILPLNLEGEELDELEAS 281
Query: 539 ATLMAKVQADIKVL 580
A++ A+I+ L
Sbjct: 282 E---AEISANIRFL 292
>UniRef50_Q9PHY2 Cluster: Probable malate dehydrogenase; n=12;
Campylobacter|Rep: Probable malate dehydrogenase -
Campylobacter jejuni
Length = 300
Score = 50.0 bits (114), Expect = 5e-05
Identities = 46/180 (25%), Positives = 81/180 (45%), Gaps = 1/180 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D L ++ ++I LD+ARF+Y L+++L + + +IG H D V V
Sbjct: 122 DFLLNTLYESGIFSSKKIIAMAGVLDNARFKYELAKKLNVKMSRVDTRLIGFHNDDMVLV 181
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIK-LKGYTSWAIGLSLSQL 358
S ++ NK I + E +++L V +VIK LK A + ++
Sbjct: 182 KSYASVK-------NKNISEFLNEEEFEDLENEVKTGGAKVIKHLKTSAYLAPASACIRM 234
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQLRKS 538
+ +I + +S L GE G+ + L + LG GV ++++ L+ E +L KS
Sbjct: 235 LESI--RSGEFLPMSVILHGEFGVQNKA-LGVMARLGLEGVIEIMKMDLSLQEKDKLEKS 291
>UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacter
hominis ATCC BAA-381|Rep: Malate dehydrogenase -
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 /
NCTC 13146 /CH001A)
Length = 297
Score = 48.8 bits (111), Expect = 1e-04
Identities = 39/151 (25%), Positives = 67/151 (44%), Gaps = 1/151 (0%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D L +V +K SG K ++I LDSAR RY +++ + T ++G H D
Sbjct: 123 DTLAFVAYKASGFKKEKIIAMAGELDSARLRYEIAKSENVNVTDIKASVVGAHNDE---- 178
Query: 182 WSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLS-QL 358
+ I L D K G P+N + E + S ++ L+ +S+ + S ++
Sbjct: 179 ---MQI----LEDEIYKFGKKFKPQNLSLIKENTINSGSKITALQKTSSFFAPAACSVKM 231
Query: 359 VRAILYNANSVHAVSTYLKGEHGIDEEVFLS 451
+ AI+ + N + S + E I V L+
Sbjct: 232 IDAIINDKNEILICSVLDENEIPIGRFVRLN 262
>UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein
OJA1212_C06.24; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Putative uncharacterized protein
OJA1212_C06.24 - Oryza sativa subsp. japonica (Rice)
Length = 255
Score = 44.8 bits (101), Expect = 0.002
Identities = 24/49 (48%), Positives = 26/49 (53%)
Frame = -2
Query: 147 IYPWQEVVAMPNLSESR*RNLAESRLVPEPITRCFGNPLIFHVT*VRMS 1
+ W S R RNL ESRLVPEP+TR GNP FH T V S
Sbjct: 34 VLTWTSWALTWRCSARRKRNLEESRLVPEPMTRLAGNPDSFHATYVSTS 82
>UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1;
Methanocorpusculum labreanum Z|Rep: Lactate/malate
dehydrogenase - Methanocorpusculum labreanum (strain
ATCC 43576 / DSM 4855 / Z)
Length = 283
Score = 44.4 bits (100), Expect = 0.002
Identities = 25/66 (37%), Positives = 39/66 (59%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
D+ T+ K S L + +V+G G LDS RF +L +GI G ++GEHG+ VP+
Sbjct: 115 DVFTWYFAKKSCLDESQVVGFGGLLDSRRFTVVLRS-IGI---EAEGQVLGEHGEHQVPL 170
Query: 182 WSGVNI 199
+S ++I
Sbjct: 171 FSSLDI 176
>UniRef50_Q5NDY3 Cluster: Putative l-lactate dehydrogenase; n=1;
Lactobacillus sanfranciscensis|Rep: Putative l-lactate
dehydrogenase - Lactobacillus sanfranciscensis
(Lactobacillus sanfrancisco)
Length = 92
Score = 43.2 bits (97), Expect = 0.006
Identities = 25/77 (32%), Positives = 34/77 (44%)
Frame = +2
Query: 119 IATTSCHGYIIGEHGDSSVPVWSGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAY 298
+A H Y++GEHGDS I V L D K G E+ EL + AY
Sbjct: 15 LAPEVVHAYVLGEHGDSEFADLDEATIGNVPLLDYAAKRGVSK--EDLLELEDKTRNKAY 72
Query: 299 EVIKLKGYTSWAIGLSL 349
+I KG T + + +L
Sbjct: 73 SIINKKGATFYGVASAL 89
>UniRef50_Q1WU75 Cluster: Lactate/malate dehydrogenase; n=1;
Lactobacillus salivarius subsp. salivarius UCC118|Rep:
Lactate/malate dehydrogenase - Lactobacillus salivarius
subsp. salivarius (strain UCC118)
Length = 294
Score = 40.7 bits (91), Expect = 0.030
Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 2/166 (1%)
Frame = +2
Query: 26 KISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVWSGVNIAG 205
K +GL +V+G GT+++S +++++LGI + +IG D S +WS +A
Sbjct: 122 KYTGLSSRQVLGLGTSIESEVVARMVAKKLGINSNYIQTSVIGTR-DKSFVLWSKGRVAE 180
Query: 206 VRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIK-LKGYTSWAIGLSLSQLVRAILYNA 382
L L +E + +K+ E+ K KG L S ++ IL
Sbjct: 181 ASLMSLIV-----------QEKNMFSIKNMQEISKEYKGLAEKTRKLIFSSVLNKILMAM 229
Query: 383 NSVHAVSTYLKGEHGIDEEV-FLSLPCVLGHSGVSDVIRQPLTETE 517
++ L H +EE+ S P ++G GV ++I+ TE E
Sbjct: 230 DTSEQFIITL--VHSRNEEIESYSSPVLVGKMGVIELIKVNYTEDE 273
>UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 237
Score = 40.7 bits (91), Expect = 0.030
Identities = 18/40 (45%), Positives = 28/40 (70%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGI 121
D++T + ++S LP +V+GSGT LDS R R LL++ G+
Sbjct: 128 DLMTSLAKELSNLPSAQVLGSGTFLDSIRLRGLLADETGV 167
>UniRef50_Q03QL8 Cluster: Malate/lactate dehydrogenase; n=1;
Lactobacillus brevis ATCC 367|Rep: Malate/lactate
dehydrogenase - Lactobacillus brevis (strain ATCC 367 /
JCM 1170)
Length = 302
Score = 38.7 bits (86), Expect = 0.12
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 4/83 (4%)
Frame = +2
Query: 8 LTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVWS 187
L+Y WK SGL +++ G GT + L++ LG+ + + +IG D + VWS
Sbjct: 117 LSYFAWKFSGLQANQIWGLGTYPLARLLTARLADHLGVGSAAVQATVIGT-ADLPIVVWS 175
Query: 188 GVNIAGV----RLSDLNKKIGTD 244
I V L++ + KI D
Sbjct: 176 RTYIGPVPILMYLANADTKISAD 198
>UniRef50_Q039N1 Cluster: Malate/lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: Malate/lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 296
Score = 38.7 bits (86), Expect = 0.12
Identities = 19/62 (30%), Positives = 32/62 (51%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPV 181
++ TY + SG+ K +V+G GT + RF L+ RL + Y++G + V +
Sbjct: 114 ELFTYFAQRFSGVNKSQVVGLGTFGATWRFEQFLAARLAVPAKHVTAYVVGTR-QAPVLI 172
Query: 182 WS 187
WS
Sbjct: 173 WS 174
>UniRef50_Q600I6 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae (strain 232)
Length = 304
Score = 36.7 bits (81), Expect = 0.48
Identities = 35/158 (22%), Positives = 69/158 (43%)
Frame = +2
Query: 5 ILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVW 184
IL + SGL +V G GT L++ F LL + + + I+G+ G+S +
Sbjct: 122 ILCKIFSSTSGLVGKKVFGIGTILENIYFNMLLKKTNSDLAKTANLLILGDQGNSFL--- 178
Query: 185 SGVNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKLKGYTSWAIGLSLSQLVR 364
+N D TD + E + +L + + + + E I K +W + L ++
Sbjct: 179 --IN------QDFKNNEITDKNNEIFDKLIQKINEKSLEKIIRKTAENWLLASILLDILL 230
Query: 365 AILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSG 478
I S ++++++ + I + F ++P + SG
Sbjct: 231 DIFQQKQSFFLINSWVESFYNIKND-FFTIPVKIDLSG 267
>UniRef50_Q182W1 Cluster: Putative exported protein precursor; n=2;
Clostridium difficile|Rep: Putative exported protein
precursor - Clostridium difficile (strain 630)
Length = 651
Score = 36.3 bits (80), Expect = 0.64
Identities = 33/128 (25%), Positives = 55/128 (42%), Gaps = 3/128 (2%)
Frame = +2
Query: 62 SGTNLDSARFRYLLSERLGIATTSCHGYIIGEHGDSSVPVWSGVNIAGVRLSDLNKKIGT 241
S +D+ +++ L+ IIGE G V + G +N I T
Sbjct: 71 SNFTIDTNKYKILIKNHGRFIIDDNELNIIGEGGKEGV---IHIENGGSISIGINNIIAT 127
Query: 242 DSDPENWKELHEMVVKSAYEVI-KLKGYTSWAIGLSLSQLVRAILYN--ANSVHAVSTYL 412
D +E ++ +KS+YE + K+K AIG+ +R + + N HA+ Y
Sbjct: 128 DGTALYVEEGGDLHIKSSYESVEKIKANGKDAIGIYTENDIRILNKDIEVNGEHAIGVYS 187
Query: 413 KGEHGIDE 436
KG+ I+E
Sbjct: 188 KGDVEIEE 195
>UniRef50_Q86S07 Cluster: NAD-specific malate dehydrogenase 2; n=1;
Entamoeba histolytica|Rep: NAD-specific malate
dehydrogenase 2 - Entamoeba histolytica
Length = 329
Score = 35.1 bits (77), Expect = 1.5
Identities = 38/152 (25%), Positives = 65/152 (42%), Gaps = 4/152 (2%)
Frame = +2
Query: 14 YVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATTSCHGYII-GEHGDSSVPVWSG 190
YV K SG+P + T LD R ++ +G H I+ G H ++ P
Sbjct: 145 YVICKTSGIPPEHITAL-TRLDQNRATAFVANEVGCQPEFVHNIIVWGNHSNTMQP---- 199
Query: 191 VNIAGVRLSDLNKKIGTDSDPENWKELHEMVVKSAYEVIKL-KGYTSWAIGLSLSQLVRA 367
+++ L+D N + E++ E V EVI K ++ + ++ Q ++
Sbjct: 200 -DLSYSYLADQNGIKPLANCIEDFDAFTEKVRCRGEEVISTRKASSAGSAAHAICQHIKD 258
Query: 368 ILYNANSVHAVSTYLK--GEHGIDEEVFLSLP 457
+Y VS + GE+GID +F S+P
Sbjct: 259 WIYGTKPGIMVSMGVSSNGEYGIDTGLFYSMP 290
>UniRef50_Q64YY6 Cluster: Malate dehydrogenase; n=5;
Bacteroidales|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 333
Score = 34.3 bits (75), Expect = 2.6
Identities = 45/195 (23%), Positives = 86/195 (44%), Gaps = 5/195 (2%)
Frame = +2
Query: 2 DILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSERLGIATT---SCHGYIIGEHGDSS 172
DI + +GL K + + LDS R + L + L I + +C Y G HG+
Sbjct: 128 DITGLIVLLYAGL-KPSQVSTLAALDSTRLQNELVKYLHIPASEIVNCRTY--GGHGEQM 184
Query: 173 VPVWSGVNIAGVRLSDLNKKIGTDSDP-ENWKELHEMVVKSAYEVIKLKGYTSWAIGLSL 349
S + G L+ K I T P ++W++L V++ +I L+G +S+ L
Sbjct: 185 AVFASTTKVQGEALT---KIIDTPRMPMQDWEDLKVRVIQGGKHIIDLRGRSSFQSPAYL 241
Query: 350 S-QLVRAILYNANSVHAVSTYLKGEHGIDEEVFLSLPCVLGHSGVSDVIRQPLTETELAQ 526
S +++ A + TY+ + + + +++ + GVS Q T E +
Sbjct: 242 SIEMIAAAMGGQPFRWPAGTYVSDKK--FDHILMAMETSITKEGVSYKEIQG-TPEEQKE 298
Query: 527 LRKSATLMAKVQADI 571
+ +S T + K++ ++
Sbjct: 299 MEESYTHLCKLRDEV 313
>UniRef50_Q7SDH8 Cluster: Putative uncharacterized protein NCU02632.1;
n=6; Pezizomycotina|Rep: Putative uncharacterized protein
NCU02632.1 - Neurospora crassa
Length = 1118
Score = 33.9 bits (74), Expect = 3.4
Identities = 28/100 (28%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Frame = +2
Query: 302 VIKLKGYTSWAIGLSLSQLVRAILYNANSVHAVSTYLKGE----HGIDE---EVFLSLPC 460
+IKL GY + +S+ + +RA++ + H +L + +G+D EVF ++
Sbjct: 784 IIKLAGYLFFGTIVSVEEKIRAMISDEEFNHRPIRFLIIDLWLVNGVDYSAGEVFNTISR 843
Query: 461 VLGHSGVSDVIRQPLTETELAQLRKSATLMAKVQADIKVL 580
+L H G+ +I TE EL + ++A L + D+K+L
Sbjct: 844 LLNHKGIELIISGVDTEQELGRHLRAAGL-GEDGIDVKLL 882
>UniRef50_Q9ZIQ2 Cluster: RTX protein; n=9; Actinobacillus
pleuropneumoniae|Rep: RTX protein - Actinobacillus
pleuropneumoniae (Haemophilus pleuropneumoniae)
Length = 1805
Score = 33.5 bits (73), Expect = 4.5
Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Frame = +2
Query: 212 LSDLNKKIGTDSDPENWKELHEMVVKSAY-EVIKLKG-YTSWAIGLSLSQLVRAILYNAN 385
L DL++ + +DP WKE +++ S Y + K +G Y +WA + S L A L A
Sbjct: 1024 LYDLSEYLSFFNDPTEWKE--GLLLLSRYIDYAKAQGFYENWA---ATSNLTIARLREAG 1078
Query: 386 SVHAVSTYLKGE 421
+ A ST LKG+
Sbjct: 1079 VIFAESTDLKGD 1090
>UniRef50_A1AP77 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Pelobacter propionicus (strain DSM 2379)
Length = 246
Score = 33.5 bits (73), Expect = 4.5
Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 2/83 (2%)
Frame = +2
Query: 98 LLSERLGIATTSCHGYIIGEHGDSSVPVWSGVNIAGVRLS--DLNKKIGTDSDPENWKEL 271
+LS+ + T C G + EHG S V + AG+RLS D K G +N
Sbjct: 119 VLSKEMAYETARCEGVHLSEHGGSGQGVIGALAGAGLRLSGNDGRMKGGLKIPADNGVIS 178
Query: 272 HEMVVKSAYEVIKLKGYTSWAIG 340
++ S EV ++ T A+G
Sbjct: 179 VAALISSFAEVDVVRSVTGEAVG 201
>UniRef50_Q0E4Q4 Cluster: Os02g0105300 protein; n=1; Oryza sativa
(japonica cultivar-group)|Rep: Os02g0105300 protein -
Oryza sativa subsp. japonica (Rice)
Length = 156
Score = 33.5 bits (73), Expect = 4.5
Identities = 18/83 (21%), Positives = 39/83 (46%)
Frame = -1
Query: 394 VNTVSIVQYSADQLGQRKSDSPRGVSFQFDHFIGALHYHFV*FLPVFRIGVSANLFI*IA 215
V+ V + + + G +D P GV+ + DH + A+H+ L + L +
Sbjct: 67 VDAVLVAEEGGGEAGDGVADGPGGVALEADHLVRAVHHRSPDSLQGLLVEALVALPQRLE 126
Query: 214 QSNSGNIYAGPHGNTAITMFSNN 146
+ G+ +A P+ + A+ + S++
Sbjct: 127 HRHPGHAHARPYRHRAVPVLSHH 149
>UniRef50_Q9N5K0 Cluster: Putative uncharacterized protein; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein - Caenorhabditis elegans
Length = 1203
Score = 33.1 bits (72), Expect = 5.9
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Frame = -2
Query: 540 ADLRN*ASSV-SVRG*RITSDTPLWPKTQGRDRNTSSSIPCSPLR*VDTA*TLLALYSIA 364
A LR+ +SV S G + TP TQG ++SS+ P S + T +A +IA
Sbjct: 436 ASLRSTQNSVTSTPGSFTVTSTPTITSTQGAMASSSSNSPTSTQAISSSTVTTVASSTIA 495
Query: 363 RTSWDNESPIAHEVYPFSLITS*ALFTTISCNSFQ 259
TS S IA P T + TT + +S Q
Sbjct: 496 PTSSQESSSIASSSAPSQSTTVITVSTTATVSSGQ 530
>UniRef50_Q2JDG2 Cluster: Methyltransferase FkbM; n=3; Frankia|Rep:
Methyltransferase FkbM - Frankia sp. (strain CcI3)
Length = 619
Score = 32.7 bits (71), Expect = 7.8
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Frame = -3
Query: 281 PFRVIPSSFQDRSQCQSFYLNRSVELRQYLRRTTREHCYHHVLQ*YIHGRK*LR-CPTSR 105
P+RV PS DR++ + F ++++ +L Q L+R R L+ G R PT R
Sbjct: 289 PYRVTPSRSPDRTETRMFRIDQATQLLQDLQRIARVAGPPTALR---FGAAVARHAPTIR 345
Query: 104 RAGN 93
RAGN
Sbjct: 346 RAGN 349
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 647,310,181
Number of Sequences: 1657284
Number of extensions: 13467090
Number of successful extensions: 36691
Number of sequences better than 10.0: 152
Number of HSP's better than 10.0 without gapping: 35476
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36580
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 48760335122
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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