Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I09A02NGRL0002_M04
(531 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 262 5e-69
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 249 4e-65
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 212 5e-54
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 206 2e-52
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 201 7e-51
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 196 3e-49
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 196 3e-49
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 186 3e-46
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 185 7e-46
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 181 8e-45
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 173 3e-42
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 167 1e-40
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 167 2e-40
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 157 1e-37
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 146 3e-34
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 135 7e-31
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 126 4e-28
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 126 4e-28
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 125 7e-28
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 124 2e-27
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 123 3e-27
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 121 9e-27
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 119 5e-26
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 118 6e-26
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 118 1e-25
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 116 3e-25
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 113 2e-24
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 112 4e-24
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 110 2e-23
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 109 4e-23
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 109 5e-23
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 107 2e-22
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 105 5e-22
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 101 1e-20
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 97 2e-19
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 95 7e-19
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 93 3e-18
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 92 8e-18
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 92 8e-18
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 91 1e-17
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 90 3e-17
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 90 3e-17
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 89 8e-17
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 87 2e-16
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 85 1e-15
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 84 2e-15
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 83 3e-15
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 83 4e-15
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 81 2e-14
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 81 2e-14
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 80 3e-14
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 80 3e-14
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 80 3e-14
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 80 4e-14
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 77 2e-13
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 75 8e-13
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 75 1e-12
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 75 1e-12
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 75 1e-12
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 74 2e-12
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 73 3e-12
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 73 4e-12
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 73 6e-12
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 72 1e-11
UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5; F... 71 1e-11
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 71 1e-11
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 71 2e-11
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 70 3e-11
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 70 4e-11
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 69 7e-11
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 67 2e-10
UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11; ... 67 2e-10
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 67 3e-10
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 65 8e-10
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 65 1e-09
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 64 1e-09
UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3; B... 63 4e-09
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 62 8e-09
UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1; C... 61 1e-08
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 60 4e-08
UniRef50_A0FP11 Cluster: Isocitrate/isopropylmalate dehydrogenas... 60 4e-08
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 60 4e-08
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 59 5e-08
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 59 7e-08
UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1; P... 58 1e-07
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 58 1e-07
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 58 1e-07
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 58 1e-07
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 58 2e-07
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 57 3e-07
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 56 4e-07
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 56 5e-07
UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2; L... 54 2e-06
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 54 2e-06
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 53 4e-06
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 52 6e-06
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 48 2e-04
UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 47 3e-04
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 46 5e-04
UniRef50_Q0A635 Cluster: Isocitrate/isopropylmalate dehydrogenas... 44 0.003
UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 42 0.007
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 42 0.009
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 42 0.012
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 41 0.016
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 41 0.021
UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3; D... 41 0.021
UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenas... 40 0.036
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 40 0.036
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 40 0.036
UniRef50_A7CDA2 Cluster: Putative uncharacterized protein; n=2; ... 35 1.0
UniRef50_Q0ZQ47 Cluster: FrbB; n=1; Streptomyces rubellomurinus|... 35 1.3
UniRef50_A0HHB1 Cluster: Putative uncharacterized protein; n=1; ... 35 1.3
UniRef50_Q5CWJ8 Cluster: Predicted degraded Zn-finger +bbox Zn f... 34 1.8
UniRef50_Q5FUX9 Cluster: Putative uncharacterized protein; n=2; ... 33 4.1
UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_030007... 33 5.4
UniRef50_A5E1Q0 Cluster: Putative uncharacterized protein; n=1; ... 33 5.4
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 33 5.4
UniRef50_Q7QXK4 Cluster: GLP_36_20953_19154; n=1; Giardia lambli... 32 7.2
UniRef50_A4AFC1 Cluster: Transcription antiterminator, BglG fami... 32 9.5
UniRef50_A5E6C5 Cluster: ATP-dependent RNA helicase DOB1; n=1; L... 32 9.5
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 262 bits (641), Expect = 5e-69
Identities = 123/176 (69%), Positives = 142/176 (80%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NVVH +SLP VK R+ D+D ++IREQTEGEYSALEHESVPG+VECLKIITA KS RIAKF
Sbjct: 132 NVVHARSLPGVKTRYQDIDIVVIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKF 191
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AFDYA+K RKKVT+VHKANIMKLGDGLFL+SCE+MAKLYPRI+F+KMIVDN TMQ+VS+
Sbjct: 192 AFDYAIKNSRKKVTSVHKANIMKLGDGLFLKSCEDMAKLYPRIEFQKMIVDNTTMQIVSH 251
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARHIFSGAVG 530
P+QFDV+VTPNLYG+I+DN + VFE GARH FS AVG
Sbjct: 252 PHQFDVLVTPNLYGSIIDNLFAGIVGGAGLVAGASYSPDTVVFEPGARHTFSEAVG 307
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 249 bits (609), Expect = 4e-65
Identities = 118/176 (67%), Positives = 136/176 (77%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NVVHVKSLP RH+++D +IIREQTEGEYS+LEHES GV+ECLKI+T AKS+RIAKF
Sbjct: 141 NVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKF 200
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AFDYA K GR KVTAVHKANIMKLGDGLFL+ CEE+A+LYP+I+FE MI+DNC MQ+V N
Sbjct: 201 AFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 260
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARHIFSGAVG 530
P QFDV+V PNLYGNI+DN E AVFE GARH F+ AVG
Sbjct: 261 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVG 316
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 212 bits (517), Expect = 5e-54
Identities = 106/169 (62%), Positives = 120/169 (71%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV+H KSLP V RH D+D +I+RE TEGEYS+LEHESV GVVE LKIIT AKS RIA++
Sbjct: 144 NVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEY 203
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF A + GRKKVTAVHKANIMKLGDGLFL+ C E+A YP+I FE MIVDN TMQ+VS
Sbjct: 204 AFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSR 263
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARH 509
P QFDVMV PNLYGNIV+N AVFE R+
Sbjct: 264 PQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRN 312
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 206 bits (503), Expect = 2e-52
Identities = 95/169 (56%), Positives = 120/169 (71%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
N+V KS+P ++ RH++VD +IIR+ TEGEYS LEHE+V GV+E LK+ T +IA++
Sbjct: 146 NIVRCKSIPGIQTRHNNVDLVIIRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQY 205
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AFD+A K RKKVTAVHKANIMK+GDGLFLR CEEM+ YP I+F MI+DNC MQ+V++
Sbjct: 206 AFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAH 265
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARH 509
P QFDVMV PNLYGNIV N + A+FE G+RH
Sbjct: 266 PQQFDVMVLPNLYGNIVSNIGASLVGGPGIVPGENIGGDYAIFESGSRH 314
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 201 bits (491), Expect = 7e-51
Identities = 98/167 (58%), Positives = 118/167 (70%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
++V+ +LP + RH +VD ++IRE TEGEY+ LEHE VPGVVE LK+IT SERIAK+
Sbjct: 124 SLVNCFNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKY 183
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+YA RKKVTAVHKANIMKL DGLFL SC E+AK YP I + ++IVDNC MQ+V+
Sbjct: 184 AFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPSITYNEIIVDNCCMQLVAK 243
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGA 503
P QFDVMVTPNLYGN+V N + AVFEQGA
Sbjct: 244 PEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGA 290
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 196 bits (478), Expect = 3e-49
Identities = 95/167 (56%), Positives = 117/167 (70%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
++V+ ++P + RH +VD ++IRE TEGEYS LEHE VPGVVE LK+IT SERIA++
Sbjct: 125 SLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARY 184
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+YA RKKVTAVHKANIMKL DGLFL SC E+AK Y I + ++IVDNC MQ+V+
Sbjct: 185 AFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAK 244
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGA 503
P QFDVMVTPNLYGN++ N E A+FEQGA
Sbjct: 245 PEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGA 291
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 196 bits (478), Expect = 3e-49
Identities = 98/171 (57%), Positives = 120/171 (70%), Gaps = 1/171 (0%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV KS+P VK R +++D +IIRE TEGEYS LEHESVPGVVE LKI+T AKSERIA+F
Sbjct: 118 NVALFKSIPGVKTRLNNIDMVIIRENTEGEYSGLEHESVPGVVESLKIMTRAKSERIARF 177
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEM-AKLYPRIQFEKMIVDNCTMQMVS 359
AFD+A+K RK V AVHKANIMKLGDGLF + E+ A YP + + +IVDN +MQ V+
Sbjct: 178 AFDFALKNNRKSVCAVHKANIMKLGDGLFRNTVNEIGANEYPELDVKNIIVDNASMQAVA 237
Query: 360 NPNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARHI 512
P+QFDV+VTPNLYG+I+ N E AVFE G+RH+
Sbjct: 238 KPHQFDVLVTPNLYGSILGNIGSALIGGPGLVPGANFGREYAVFEPGSRHV 288
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 186 bits (453), Expect = 3e-46
Identities = 85/176 (48%), Positives = 112/176 (63%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NVVH KS P + RHHD+D ++IR+ T+GEY+ LEHESVPG+VE +K++T +ER+A++
Sbjct: 147 NVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARY 206
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF++A + RKKVT +HKANIMKL DGLFL + K YP ++ MI+DN MQ VSN
Sbjct: 207 AFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSN 266
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARHIFSGAVG 530
P+QFDVM NLYG IV N A+FE G R+ + G
Sbjct: 267 PHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPGTRNTGTAIAG 322
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 185 bits (450), Expect = 7e-46
Identities = 94/171 (54%), Positives = 114/171 (66%), Gaps = 1/171 (0%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV KSL VK R D+D I+IRE TEGE+S LEHESVPGVVE LK++T K+ERIA+F
Sbjct: 117 NVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARF 176
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMA-KLYPRIQFEKMIVDNCTMQMVS 359
AFD+A K RK VTAVHKANIMKLGDGLF E+ K YP I +IVDN +MQ V+
Sbjct: 177 AFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVA 236
Query: 360 NPNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARHI 512
P+QFDV+VTP++YG I+ N + AVFE G+RH+
Sbjct: 237 KPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHV 287
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 181 bits (441), Expect = 8e-45
Identities = 88/176 (50%), Positives = 111/176 (63%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV+H KS + H +VD +IIR+ TEGEY+ LEHESV GVVE +K++T + R+A++
Sbjct: 139 NVLHCKSFNAIPAHHQNVDVVIIRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARY 198
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF++A RKKVT +HKANIMKL DGLFL E+AK YP IQ MI+DNC MQ+VSN
Sbjct: 199 AFEFARANNRKKVTTIHKANIMKLADGLFLSVAREVAKDYPDIQHNDMIIDNCCMQLVSN 258
Query: 363 PNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFEQGARHIFSGAVG 530
P+QFDVM T NLYG+I N AVFE G R+ + G
Sbjct: 259 PHQFDVMNTTNLYGSITSNVLCGLVGGAGLFSGRNYGDHFAVFEPGTRNTGTAIAG 314
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 173 bits (420), Expect = 3e-42
Identities = 82/139 (58%), Positives = 102/139 (73%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV SLP K R+ DVD I IRE TEGEYS LEH+ V GVVE LKIIT S R+A++
Sbjct: 135 NVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEY 194
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF YA GRKKV+A+HKANIM+ DGLFL+ C+E+A YP I +EK+++DNC M +V N
Sbjct: 195 AFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKN 254
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P FDV+V PNLYG+I+ +
Sbjct: 255 PALFDVLVMPNLYGDIISD 273
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 167 bits (407), Expect = 1e-40
Identities = 79/139 (56%), Positives = 104/139 (74%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NVV +S P V+ RH ++D +++R+ TEGEYS LE ES+ VVE L+ +T AK R+A++
Sbjct: 21 NVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLRLAEY 80
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF A +MG KKVTA +KANIM+LGD LF++ C E+A YP++ FE MIV N MQ+VS
Sbjct: 81 AFQLAHRMGCKKVTATYKANIMRLGDCLFIQCCREVASHYPQLSFEGMIVGNTPMQLVSG 140
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P QFDVMV P+LYGNIV+N
Sbjct: 141 PQQFDVMVMPSLYGNIVNN 159
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 167 bits (405), Expect = 2e-40
Identities = 77/139 (55%), Positives = 103/139 (74%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV +++LP V R+ VD +++RE TEG YS +EHE VPGVVE LKIIT S RI+KF
Sbjct: 94 NVRPIRNLPGVHTRYPGVDLVVVRENTEGLYSGIEHEVVPGVVESLKIITEKASTRISKF 153
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+YA KMGRKK+ ++HKANIMK+ DGLF+R ++K YP I + + IVDN MQ+V N
Sbjct: 154 AFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMN 213
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P Q+D+++ NLYG+IV +
Sbjct: 214 PYQYDILLLENLYGDIVSD 232
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 157 bits (382), Expect = 1e-37
Identities = 74/139 (53%), Positives = 98/139 (70%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV +SL K + +VD + IRE TEGEYS +EHE VPGVV+ +K+IT S +A F
Sbjct: 116 NVRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASF 175
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+YA + GRK VTAVHKANIM+ DGLFL C E A LYP I+F++ +D + MV +
Sbjct: 176 AFEYARQNGRKVVTAVHKANIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQD 235
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P+Q+DV+V PNLYG+I+ +
Sbjct: 236 PSQYDVLVMPNLYGDILSD 254
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 146 bits (354), Expect = 3e-34
Identities = 70/139 (50%), Positives = 96/139 (69%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV S+ K + DV+ + IRE TEGEYS +EH V GVV+ +K+IT S+RIA+F
Sbjct: 123 NVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEF 182
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+YA R VTAVHKANIM++ DGLFL+ C E+A+ I+F +M +D + MV +
Sbjct: 183 AFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQD 242
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P+QFDV+V PNLYG+I+ +
Sbjct: 243 PSQFDVLVMPNLYGDILSD 261
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 135 bits (326), Expect = 7e-31
Identities = 62/141 (43%), Positives = 95/141 (67%), Gaps = 2/141 (1%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV KS+ K + +VD ++IRE TEGEYS +EH PGVV+ +K+IT SER+ ++
Sbjct: 127 NVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRY 186
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+YA +GR +V VHK+ I +L DGLF+ +E++K YP + E ++DN +++V+N
Sbjct: 187 AFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTN 246
Query: 363 PNQFD--VMVTPNLYGNIVDN 419
P+ + V V PNLYG+I+ +
Sbjct: 247 PSAYTDAVSVCPNLYGDILSD 267
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 126 bits (303), Expect = 4e-28
Identities = 67/159 (42%), Positives = 99/159 (62%), Gaps = 20/159 (12%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHE-SVPGVVECLKI----------- 146
N+ ++LP V R+ ++D +++RE TE YS +E E + P +E +++
Sbjct: 95 NLRPARTLPGVHSRYDNIDLVVVRENTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFP 154
Query: 147 --------ITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLY 302
I++ SERIA+FAF+YA + R+KVTAVHKANI+K DGLFL + ++A Y
Sbjct: 155 RSGLAVKPISSEASERIARFAFEYARRHARRKVTAVHKANILKHTDGLFLEAARQVASEY 214
Query: 303 PRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
P ++FE IVDN MQ+V P +DV+V PNLYG+IV +
Sbjct: 215 PDVEFEDRIVDNLCMQLVQRPESYDVLVLPNLYGDIVSD 253
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 126 bits (303), Expect = 4e-28
Identities = 60/140 (42%), Positives = 93/140 (66%), Gaps = 1/140 (0%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
N+ KS P++ D+D +I+RE TE Y+ E V L+II+ S+RIAK+
Sbjct: 93 NIRPAKSYPHMPALRDDIDMVIVRENTEDLYTGKEFSLGDSSV-ALRIISEQASKRIAKY 151
Query: 183 AFDYA-VKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVS 359
AF+ A ++ +KKVT VHK+N+M++ DG+F ++C E++K YP I FE+M VD C M ++
Sbjct: 152 AFETAKMRNDKKKVTCVHKSNVMRVTDGMFAKACTEVSKDYPDISFEQMYVDACAMNLIR 211
Query: 360 NPNQFDVMVTPNLYGNIVDN 419
P +FDV+VT NL+G+I+ +
Sbjct: 212 QPQEFDVVVTTNLFGDILSD 231
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 125 bits (301), Expect = 7e-28
Identities = 60/93 (64%), Positives = 72/93 (77%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
+V+H+K+LPNV+ H DVD +++ E TEGEYS LEHESV GV E LKI+T AKS RIA++
Sbjct: 11 SVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTKAKSLRIAEY 70
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSC 281
AF A KMG KKV AVHK NI KLGDG FL+ C
Sbjct: 71 AFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 124 bits (298), Expect = 2e-27
Identities = 60/139 (43%), Positives = 89/139 (64%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV K++ ++C + +D +++RE TE Y E V E +++IT SERIA++
Sbjct: 89 NVRPAKAIEGIECLYPGLDIVVVRENTECLYMGFEF-GFGDVTEAIRVITREASERIARY 147
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+ A + GRKKVTA+HKAN+MK GLF C E+AK YP IQ+ +D M +V +
Sbjct: 148 AFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMD 207
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P +FDV+VT N++G+IV +
Sbjct: 208 PFRFDVIVTTNMFGDIVSD 226
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 123 bits (296), Expect = 3e-27
Identities = 68/159 (42%), Positives = 93/159 (58%), Gaps = 20/159 (12%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHE-SVPGVVEC-------------- 137
N+ KSLP +K D+D +++RE TE Y+ +E E P
Sbjct: 94 NLRPAKSLPGIKSPFQDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIRE 153
Query: 138 -----LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLY 302
+K I+ S RI KFAF+YA + GRKKVTAVHKANIMK DGLFL+ E+A+ Y
Sbjct: 154 GSAIGIKPISEFGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY 213
Query: 303 PRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
P I+FE +IVDN +Q++ P +DV+V NLYG+I+ +
Sbjct: 214 PDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYGDIISD 252
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 121 bits (292), Expect = 9e-27
Identities = 59/139 (42%), Positives = 88/139 (63%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
N+ KS+P + ++ +VD +I+RE TE Y EH GV +KIIT SERIAK
Sbjct: 94 NIRPAKSIPGIDTKYGNVDILIVRENTEDLYKGFEHIVSDGVAVGMKIITRFASERIAKV 153
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
++A++ RKKVT VHKAN+M++ DGLF +C + K ++++ +M VD +V N
Sbjct: 154 GLNFALRR-RKKVTCVHKANVMRITDGLFAEACRSVLK--GKVEYSEMYVDAAAANLVRN 210
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P FDV+VT N+YG+I+ +
Sbjct: 211 PQMFDVIVTENVYGDILSD 229
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 119 bits (286), Expect = 5e-26
Identities = 62/135 (45%), Positives = 83/135 (61%)
Frame = +3
Query: 15 VKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDY 194
V P V +H D+D +IIRE E YS +EH+ EC+KI T + SE+I +AF+Y
Sbjct: 105 VSYFPVVGTKHPDLDVVIIRENEEDTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNY 164
Query: 195 AVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQF 374
A RKKVT K NIMK+ DG+ S +++AK YP I+ IVD ++ SNP F
Sbjct: 165 ARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDF 224
Query: 375 DVMVTPNLYGNIVDN 419
DV+VT NLYG+IV +
Sbjct: 225 DVVVTTNLYGDIVSD 239
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 118 bits (285), Expect = 6e-26
Identities = 54/122 (44%), Positives = 85/122 (69%), Gaps = 1/122 (0%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAV 230
D D +IIR+Q EG+YS +EH VPGV++ +K+ T A + RIA+F F+YAVK RK++T
Sbjct: 168 DFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVA 227
Query: 231 HKANIMKLGDGLFLRSCE-EMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGN 407
HKANIM++ DG FL + E K + FE+ +D C ++++ P++ DVMV+ ++YG+
Sbjct: 228 HKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGD 287
Query: 408 IV 413
++
Sbjct: 288 VL 289
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 118 bits (283), Expect = 1e-25
Identities = 62/166 (37%), Positives = 92/166 (55%), Gaps = 2/166 (1%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRH--HDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIA 176
NV V+ PNV + +D +++RE E Y+ +EH P V + LK+I+ SE+I
Sbjct: 112 NVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIV 171
Query: 177 KFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMV 356
+FAF+ A GRKKV K+NIMKL +G R+ E++A+ YP I+ +IVDN Q+V
Sbjct: 172 RFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLV 231
Query: 357 SNPNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFE 494
P QF+V+VT N+ G+I+ + E A+FE
Sbjct: 232 KRPEQFEVIVTTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFE 277
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 116 bits (279), Expect = 3e-25
Identities = 59/139 (42%), Positives = 86/139 (61%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
N+ VKSLP V C + D+D +I+RE TE Y E + G V +IIT S RI++F
Sbjct: 91 NLRPVKSLPGVPCLYPDLDFVIVRENTEDLYVGDEEYTPEGAV-AKRIITRTASRRISQF 149
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF YA K G +KVTAVHKAN++K DG+F ++A YP+++ VD M +++
Sbjct: 150 AFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQ 209
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P +F +VT NL+G+I+ +
Sbjct: 210 PQEFQTIVTTNLFGDILSD 228
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 113 bits (272), Expect = 2e-24
Identities = 59/143 (41%), Positives = 88/143 (61%), Gaps = 4/143 (2%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
N+ VK+ VKC D+D +I+RE TEG Y +E E G+ ++IT ERI +F
Sbjct: 89 NIRPVKAYKGVKCLRPDIDYVIVRENTEGLYKGIEAEIDEGITIATRVITEKACERIFRF 148
Query: 183 AFDYA---VKMGRK-KVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQ 350
AF+ A KMG++ KVT HKAN++KL DGLF + ++A+ Y I+ E +D M
Sbjct: 149 AFNLARERKKMGKEGKVTCAHKANVLKLTDGLFKKIFYKVAEEYDDIKAEDYYIDAMNMY 208
Query: 351 MVSNPNQFDVMVTPNLYGNIVDN 419
+++ P FDV+VT NL+G+I+ +
Sbjct: 209 IITKPQVFDVVVTSNLFGDILSD 231
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 112 bits (270), Expect = 4e-24
Identities = 59/132 (44%), Positives = 83/132 (62%), Gaps = 6/132 (4%)
Frame = +3
Query: 42 RHHDVDCIIIREQTEGEYSALEH-----ESVPGVVECLKIITAAKSERIAKFAFDYAVKM 206
R+ +D +++RE EG Y EH + V I T A S RI+KFAFDYAV+
Sbjct: 113 RYEKIDLVLVRENLEGLYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRN 172
Query: 207 GRKKVTAVHKANIMKLGDGLFLRSCEEMAKLY-PRIQFEKMIVDNCTMQMVSNPNQFDVM 383
R+KVT VHKAN++K GLFL + +++ Y +I+F IVD C MQ+V NP QFDV+
Sbjct: 173 NRRKVTIVHKANVLKALTGLFLETAKQVGLNYADQIEFNDRIVDACAMQLVLNPWQFDVI 232
Query: 384 VTPNLYGNIVDN 419
V+ NL+G+I+ +
Sbjct: 233 VSTNLFGDILSD 244
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 110 bits (264), Expect = 2e-23
Identities = 53/125 (42%), Positives = 79/125 (63%)
Frame = +3
Query: 45 HHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVT 224
H ++ IIRE E Y+ +E+ + E +K+I+ E+I ++AF+YAVK RKKVT
Sbjct: 112 HPHLNLTIIRENEEDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVT 171
Query: 225 AVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYG 404
+ K NIMK DG+F + E+AK YP+I E I+D T ++ + P FDV+VT NLYG
Sbjct: 172 CLSKDNIMKFSDGVFHKIFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVIVTSNLYG 231
Query: 405 NIVDN 419
+I+ +
Sbjct: 232 DIISD 236
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 109 bits (262), Expect = 4e-23
Identities = 54/133 (40%), Positives = 84/133 (63%), Gaps = 1/133 (0%)
Frame = +3
Query: 15 VKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVV-ECLKIITAAKSERIAKFAFD 191
++ + RH +D +I+RE TE Y E G E +K +T + S +++++AF+
Sbjct: 109 IRGYVGISGRHEKMDMVIMREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFE 168
Query: 192 YAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQ 371
YA K GRKKV+ +HKAN++ DGLFLR+ +E+A+LYP I + M++D +V +P
Sbjct: 169 YARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPCW 228
Query: 372 FDVMVTPNLYGNI 410
FDV+VT N YG+I
Sbjct: 229 FDVVVTVNQYGDI 241
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 109 bits (261), Expect = 5e-23
Identities = 50/131 (38%), Positives = 83/131 (63%)
Frame = +3
Query: 27 PNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKM 206
P V ++D +IIRE E Y+ +E+ E +K+I+ + SE+I +FAF+YA+K
Sbjct: 106 PFVNTSAPEIDVVIIRENEEDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKN 165
Query: 207 GRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMV 386
RK ++ K NIMK DG+F ++ E+A Y IQ + ++D + +++S+P +FDV+V
Sbjct: 166 NRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIV 225
Query: 387 TPNLYGNIVDN 419
T NLYG+I+ +
Sbjct: 226 TSNLYGDILSD 236
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 107 bits (256), Expect = 2e-22
Identities = 52/124 (41%), Positives = 83/124 (66%), Gaps = 1/124 (0%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEH-ESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTA 227
++D +IIRE TE Y E E+ + E ++IT SERI +FAF+YA+K RKKV+
Sbjct: 121 NIDIVIIRENTEDLYVGRERLENDTAIAE--RVITRKGSERIIRFAFEYAIKNNRKKVSC 178
Query: 228 VHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGN 407
+HKAN++++ DGLFL E+ K Y I+ + +VD+ M ++ +P +FDV+VT N++G+
Sbjct: 179 IHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGD 237
Query: 408 IVDN 419
I+ +
Sbjct: 238 ILSD 241
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 105 bits (253), Expect = 5e-22
Identities = 51/97 (52%), Positives = 68/97 (70%), Gaps = 2/97 (2%)
Frame = +3
Query: 42 RHHDVDCIIIREQTEGEYSALEHESVPGVVECLKI-ITAAKSERIAKFAFDYAVKMGRKK 218
RH +VD ++IRE TEGEY+ EHE VPGV+E ++ +T S+RIAK+AF+YA RKK
Sbjct: 91 RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKK 150
Query: 219 VTAVH-KANIMKLGDGLFLRSCEEMAKLYPRIQFEKM 326
VTAVH KL D FL SC+E+AK+YP I + ++
Sbjct: 151 VTAVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEI 187
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 101 bits (241), Expect = 1e-20
Identities = 47/84 (55%), Positives = 56/84 (66%)
Frame = +3
Query: 279 CEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXX 458
CEE+A+LYP+I+FE MI+DNC MQ+V NP QFDV+V PNLYGNI+DN
Sbjct: 179 CEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVP 238
Query: 459 XXXXXXECAVFEQGARHIFSGAVG 530
E AVFE GARH F+ AVG
Sbjct: 239 GESYSAEYAVFETGARHPFAQAVG 262
Score = 64.1 bits (149), Expect = 2e-09
Identities = 29/44 (65%), Positives = 34/44 (77%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVE 134
NVVHVKSLP RH+++D +IIREQTEGEYS+LEHE V E
Sbjct: 141 NVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHECCEEVAE 184
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 97.1 bits (231), Expect = 2e-19
Identities = 54/139 (38%), Positives = 80/139 (57%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV K+ P V + +VD +I+RE T+G Y E + +IT S+RI KF
Sbjct: 98 NVRPTKTRP-VPHSYENVDLVIVRENTQGLYVEQERRYGDTAIADT-VITREASDRIGKF 155
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
A D A+K K++T VHK+N++ + GLF+ + + K + MIVDN MQ+V N
Sbjct: 156 AADLAMKRS-KRLTVVHKSNVLPVTQGLFMNTILDHTKTVEGLSTSTMIVDNAAMQLVRN 214
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P QFDVMV N++G+I+ +
Sbjct: 215 PQQFDVMVMTNMFGDILSD 233
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 95.5 bits (227), Expect = 7e-19
Identities = 53/137 (38%), Positives = 83/137 (60%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
N+ VK+LP V ++DC+ +RE E Y E++ V V LK+IT + R+A+
Sbjct: 59 NIRPVKNLPGVPAVR-EIDCVFVRENVEDVYVGAEYK-VGDVAIALKVITEKGTRRVARM 116
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
A YA +M R++VT VHKAN++++ DG F E K ++ ++M VD M++V N
Sbjct: 117 ARKYA-EMRRRRVTIVHKANVLRVVDGFFRDIALEELK---GLEVDQMYVDAAAMELVRN 172
Query: 363 PNQFDVMVTPNLYGNIV 413
P +FDV++T N YG+I+
Sbjct: 173 PKRFDVVLTMNQYGDIL 189
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 93.5 bits (222), Expect = 3e-18
Identities = 51/130 (39%), Positives = 77/130 (59%), Gaps = 7/130 (5%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHES-------VPGVVECLKIITAAKSERIAKFAFDYAVKMG 209
D D +++RE TEG Y+ E P V L+ IT A ERIA A A+K
Sbjct: 128 DFDLVVVRENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACRLAMKR- 186
Query: 210 RKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVT 389
R+ +T VHKAN++K+GDG+FL C AK Y ++ + ++VD +V NP++FDV+V
Sbjct: 187 RRHLTIVHKANVLKIGDGMFLDICRAAAKGYAGLEVDDILVDAMMAHVVRNPDRFDVIVA 246
Query: 390 PNLYGNIVDN 419
N++G+I+ +
Sbjct: 247 TNMFGDILSD 256
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 91.9 bits (218), Expect = 8e-18
Identities = 50/129 (38%), Positives = 77/129 (59%), Gaps = 7/129 (5%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSA-------LEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGR 212
+D +I+RE TEG Y E P + L+ IT SERIA+ AF+ A+K +
Sbjct: 120 MDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR-K 178
Query: 213 KKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTP 392
KKVTA+HKAN + DGLFL ++A+ +P ++ + +++D T +V P +FDV+V
Sbjct: 179 KKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLVAT 238
Query: 393 NLYGNIVDN 419
N YG+I+ +
Sbjct: 239 NFYGDIISD 247
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 91.9 bits (218), Expect = 8e-18
Identities = 47/144 (32%), Positives = 79/144 (54%), Gaps = 7/144 (4%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEY-------SALEHESVPGVVECLKIITAAK 161
NV +S P + C D+D +I+RE EG + E V +++IT
Sbjct: 104 NVRPTRSYPGIGCLFDDIDLVIVRENNEGFQPDRNVVAGSGEFRPTEDVTISVRVITVEG 163
Query: 162 SERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNC 341
++ + A D A RKK+T VHK + KLG G+F+ + E+AK YP ++ ++ IVD
Sbjct: 164 CRKVVRAALDIARSRPRKKLTLVHKNTVFKLGCGMFVDTAYEVAKEYPDVEVDECIVDTF 223
Query: 342 TMQMVSNPNQFDVMVTPNLYGNIV 413
M+++ +P +D +VT N++G+I+
Sbjct: 224 AMRLLRDPWAYDTVVTTNMFGDIL 247
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 91.1 bits (216), Expect = 1e-17
Identities = 48/139 (34%), Positives = 79/139 (56%), Gaps = 2/139 (1%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKF 182
NV +K+ PN DV+ + +RE TEG Y E + V ++ IT S +IA++
Sbjct: 97 NVRPIKTFPNSNAPLGDVEMVCVREGTEGLYIGEEIQLTDDVSIAIRKITRTASGKIARY 156
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+ A + G V +HK+NI+KL G FL E++A+ YP I+ +DN Q++ N
Sbjct: 157 AFEEAKRRGYDTVVPIHKSNILKLTCGSFLEEVEKVAQDYPNIEVWPYHIDNIAQQLIKN 216
Query: 363 PNQFD--VMVTPNLYGNIV 413
P F+ V+++ NL+ +++
Sbjct: 217 PQIFNKKVLLSTNLFMDVI 235
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 90.2 bits (214), Expect = 3e-17
Identities = 45/120 (37%), Positives = 72/120 (60%)
Frame = -2
Query: 368 VRVRYHLHRAVVHDHLLELDPGVQLRHLFTTPKEESIT*FHDVRLVDGGYLLTAHLDRVI 189
+R+ + LHR +V + +++LD VQL H+F E++I+ FHD+ LVDGG LT L +
Sbjct: 1 MRLGHSLHRGIVDNKIIDLDSRVQLTHIFHGLTEQTISQFHDIGLVDGGDQLTVVLLGKV 60
Query: 188 ESEFRDTFRFRSGDNLQALDHARHRLMFQSGVFSFCLFSDDDAVDIVMPALHVRQGLDMN 9
+ + D+ F G +L L+H R RL+FQS +F+F +FSD+ V+ + L D +
Sbjct: 61 KCKLGDSLGFEPGHDLHRLNHTRVRLVFQSRIFTFSVFSDEGKVNALQTRLDAGNVFDQD 120
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 89.8 bits (213), Expect = 3e-17
Identities = 53/144 (36%), Positives = 85/144 (59%), Gaps = 5/144 (3%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEH---ESVPG--VVECLKIITAAKSE 167
N+ K LP V +VD II+RE E Y E+ ++ G V L++ + ++
Sbjct: 93 NIRPAKVLPGVPALKENVDLIIVRENIEDLYVGAENLLPQTSLGHKVAVGLRLASERETR 152
Query: 168 RIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTM 347
R+AK A +YA K R KVT VHKAN+M++ GLF +E+ + ++ ++M VD M
Sbjct: 153 RVAKVAAEYA-KARRNKVTIVHKANVMRVTCGLFRDVAKEVLEA-EGVEVDEMYVDAAAM 210
Query: 348 QMVSNPNQFDVMVTPNLYGNIVDN 419
++V P +FDVM+TPN++G+I+ +
Sbjct: 211 ELVRRPERFDVMLTPNVFGDILSD 234
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 88.6 bits (210), Expect = 8e-17
Identities = 49/136 (36%), Positives = 76/136 (55%), Gaps = 10/136 (7%)
Frame = +3
Query: 42 RHHDVDCIIIREQTEGEYSALEHESVPGVVECL-KIITAAKSERIAKFAFDYA-----VK 203
R VD +++RE TE Y+ E G ++IT S RI + A D A +
Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSAR 174
Query: 204 MGRK----KVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQ 371
G +VT VHKAN+++ GLF E+A+ YP +Q ++M+VD C +Q+ + P +
Sbjct: 175 NGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPER 234
Query: 372 FDVMVTPNLYGNIVDN 419
FDV+VT NL+G+I+ +
Sbjct: 235 FDVIVTTNLFGDILSD 250
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 87.0 bits (206), Expect = 2e-16
Identities = 48/124 (38%), Positives = 72/124 (58%), Gaps = 4/124 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALE---HESVPGVVECLKII-TAAKSERIAKFAFDYAVKMGRKKV 221
+D + IRE TEG Y+ + P V ++I T ER +FAF+YA GRKKV
Sbjct: 120 IDMVFIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKGRKKV 179
Query: 222 TAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLY 401
T V KAN++ L+ R +E+A Y I+ + VD M+M+ +P F+V+VTPN++
Sbjct: 180 TLVDKANVLTYAHDLWQRVFKEVASEYQEIETDHYYVDAMAMKMIRSPEIFEVVVTPNMF 239
Query: 402 GNIV 413
G+I+
Sbjct: 240 GDIL 243
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 84.6 bits (200), Expect = 1e-15
Identities = 45/124 (36%), Positives = 74/124 (59%), Gaps = 4/124 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALE---HESVPGVVECLKII-TAAKSERIAKFAFDYAVKMGRKKV 221
+D + +RE TEG Y+ + P + ++I T ER+ +FAF+YA + GRKKV
Sbjct: 121 IDIVFVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKV 180
Query: 222 TAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLY 401
T V KAN++ L+ R E+++ Y ++ + VD M+M+ +P FDV+VTPN++
Sbjct: 181 TLVDKANVLTYAHDLWERVFAEVSQEYD-LETDHYYVDAMAMKMIRSPESFDVVVTPNMF 239
Query: 402 GNIV 413
G+I+
Sbjct: 240 GDIL 243
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 83.8 bits (198), Expect = 2e-15
Identities = 47/124 (37%), Positives = 67/124 (54%), Gaps = 4/124 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEY--SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTA 227
+D + RE TEGEY + + K+IT SERI + AFDYA + +V+
Sbjct: 129 IDWVFFRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSV 188
Query: 228 VHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQ--FDVMVTPNLY 401
V KAN++K DG FL ++K YP I F+ VD ++V + F V+V PNLY
Sbjct: 189 VTKANVVKTTDGKFLEIARAISKEYPEITFDDWFVDIMAAKLVDTKRRRDFRVIVLPNLY 248
Query: 402 GNIV 413
G+I+
Sbjct: 249 GDIL 252
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 83.4 bits (197), Expect = 3e-15
Identities = 52/147 (35%), Positives = 77/147 (52%), Gaps = 8/147 (5%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYS-------ALEHESVPGVVECLKIITAAK 161
N+ +SL V D+D +I+RE TEG Y+ + E P V + ++T
Sbjct: 111 NIRPARSLEGVASTVPDMDLVIVRENTEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKA 170
Query: 162 SERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKL-YPRIQFEKMIVDN 338
ERIA AF A GR VT VHKAN++ + GLF C E+ + YP ++ + VD
Sbjct: 171 CERIAHTAFALARTRGRH-VTIVHKANVLSMTTGLFRDVCREVGQRDYPDVRIDDEHVDA 229
Query: 339 CTMQMVSNPNQFDVMVTPNLYGNIVDN 419
T +V FDV+VT N++G+I+ +
Sbjct: 230 MTAHLVRRGRDFDVVVTENMFGDILSD 256
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 83.0 bits (196), Expect = 4e-15
Identities = 41/125 (32%), Positives = 78/125 (62%), Gaps = 4/125 (3%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKK 218
++D +++RE TEG Y+ A+ + + T +ER+ ++AF+ A + R+
Sbjct: 115 EIDFVVVREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELA-QSRRRH 173
Query: 219 VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNL 398
+T VHK N++ G GL+ R+ +E+A+ YP + + +D T+ +V++P++FDV+VT NL
Sbjct: 174 LTLVHKTNVLVHGGGLWQRTVDEVAREYPEVTVDYNHIDAATIYLVTDPSRFDVIVTDNL 233
Query: 399 YGNIV 413
+G+I+
Sbjct: 234 FGDIL 238
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 81.0 bits (191), Expect = 2e-14
Identities = 52/152 (34%), Positives = 82/152 (53%), Gaps = 13/152 (8%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEH---ESVPG--VVECLKIITAAKSE 167
NV VKS+ K + +D +I+RE TE Y +E + G V + K I+ +
Sbjct: 122 NVRPVKSVEGEKGK--PIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATR 179
Query: 168 RIAKFAFDYAVKM----GRKKVTAVHKANIMKLGDGLFLRSCEEMAKL----YPRIQFEK 323
RIA A D A+K G+ +T HK+N++ DGLF C+E+ + Y +I++ +
Sbjct: 180 RIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNE 239
Query: 324 MIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
IVD+ ++ P FDV+V PNLYG+I+ +
Sbjct: 240 QIVDSMVYRLFREPQCFDVIVAPNLYGDILSD 271
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 80.6 bits (190), Expect = 2e-14
Identities = 51/149 (34%), Positives = 79/149 (53%), Gaps = 10/149 (6%)
Frame = +3
Query: 3 NVVHVKSLPNVKC-----RHHDVDCIIIREQTEGEYSALE----HESVPGVVECLKIITA 155
N+ V+ P V C + D+D +++RE TEGEYS+L + +V I T
Sbjct: 106 NIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTR 165
Query: 156 AKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVD 335
+RI K+AFD A K RK VT+ K+N M + + + E MA YP + ++K +D
Sbjct: 166 RGVDRILKYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHID 225
Query: 336 NCTMQMVSNPNQFD-VMVTPNLYGNIVDN 419
+ V P +FD V+V NL+G+I+ +
Sbjct: 226 ILCARFVLQPERFDVVVVASNLFGDILSD 254
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 80.2 bits (189), Expect = 3e-14
Identities = 53/145 (36%), Positives = 83/145 (57%), Gaps = 11/145 (7%)
Frame = +3
Query: 18 KSLPNVKCRHHDVDCIIIREQTEGEYSA-----LEHESVPGVVECLKIITAAKSERIAKF 182
K +P+ R +D +I+RE +EG Y+A L E V V+ L + T ERI +F
Sbjct: 112 KGVPSPLGRPGPIDYVIVRENSEGLYAARGAGALLREEV--AVDTL-VQTRKGVERIVRF 168
Query: 183 AFDYA------VKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCT 344
AF+ A K GR++VT KAN+++ F +E+AK YP I+ E ++VD T
Sbjct: 169 AFELARTRNGSPKDGRRRVTCCDKANVLRTY-AFFRAVFDEVAKEYPDIEAEHVLVDAMT 227
Query: 345 MQMVSNPNQFDVMVTPNLYGNIVDN 419
+ +V+ P FDV+VT N++G+I+ +
Sbjct: 228 VHLVNKPTHFDVIVTENMFGDIISD 252
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 80.2 bits (189), Expect = 3e-14
Identities = 47/121 (38%), Positives = 68/121 (56%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAV 230
+ D I IRE T G Y +++ + T + ERI K AF+YA+K RK +T V
Sbjct: 128 NADFICIRELTGGMYFGEKYQDNDKAYDT-NYYTRPEIERILKVAFEYAMKR-RKHLTVV 185
Query: 231 HKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNI 410
KAN++ L+ + +EMA YP + + M VDN M+M+ P FDVMVT N +G+I
Sbjct: 186 DKANVLA-SSRLWRQIAQEMAPNYPEVTTDYMFVDNAAMKMIQEPAFFDVMVTENTFGDI 244
Query: 411 V 413
+
Sbjct: 245 L 245
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 80.2 bits (189), Expect = 3e-14
Identities = 43/123 (34%), Positives = 71/123 (57%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAV 230
++D +++RE T G Y + E V + ERI AF A K +KKVT++
Sbjct: 123 EIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASKR-KKKVTSI 181
Query: 231 HKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNI 410
KAN+++ L+ EE+A YP ++ E ++VD M+++ NP +FDV+VT NL+G+I
Sbjct: 182 DKANVLE-SSKLWRIVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDI 240
Query: 411 VDN 419
+ +
Sbjct: 241 LSD 243
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 79.8 bits (188), Expect = 4e-14
Identities = 42/125 (33%), Positives = 73/125 (58%), Gaps = 4/125 (3%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKK 218
+VD +++RE TEG Y+ AL + + + + TA ER+ + AF A + RKK
Sbjct: 252 EVDFVVVREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRRPRKK 311
Query: 219 VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNL 398
+T VHK N++ ++ R +++A YP + + M +D + M ++P +FDV+VT NL
Sbjct: 312 LTLVHKTNVLVNAGAVWWRITQQVAAEYPEVSVDYMHIDAAMIFMTTDPARFDVIVTDNL 371
Query: 399 YGNIV 413
+G+I+
Sbjct: 372 FGDII 376
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 77.4 bits (182), Expect = 2e-13
Identities = 43/135 (31%), Positives = 76/135 (56%), Gaps = 4/135 (2%)
Frame = +3
Query: 27 PNVKCRHHDVDCIIIREQTEGEYSALE---HESVP-GVVECLKIITAAKSERIAKFAFDY 194
P +C+ D++ +I+RE +EGEYS + H+ P + I+T A ERI +FAF
Sbjct: 116 PLKRCKPGDLNWVIVRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRL 175
Query: 195 AVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQF 374
A RK +T + K+N + L+ E++K +P ++++K +VD T +M++ P
Sbjct: 176 AQSRPRKLLTVITKSNAQRHAMVLWDEIALEISKEFPDVKWDKELVDASTARMINRPATL 235
Query: 375 DVMVTPNLYGNIVDN 419
D +V NL+ +I+ +
Sbjct: 236 DTIVATNLHADILSD 250
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 75.4 bits (177), Expect = 8e-13
Identities = 42/128 (32%), Positives = 72/128 (56%), Gaps = 4/128 (3%)
Frame = +3
Query: 42 RHHDVDCIIIREQTEGEYSALEHESVPG----VVECLKIITAAKSERIAKFAFDYAVKMG 209
+ D+D + IRE +EGEY+ G VV + + +ERI ++AF+ A K
Sbjct: 121 KREDIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARKE- 179
Query: 210 RKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVT 389
RK +T++ K N + + + EE++K YP ++ +VD M M+ P++F+V+VT
Sbjct: 180 RKSLTSISKGNALNYSMVFWDQIFEEISKEYPDVKTASYLVDAAAMLMIKEPHRFEVVVT 239
Query: 390 PNLYGNIV 413
NL+G+I+
Sbjct: 240 SNLFGDIL 247
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 74.9 bits (176), Expect = 1e-12
Identities = 48/148 (32%), Positives = 75/148 (50%), Gaps = 9/148 (6%)
Frame = +3
Query: 3 NVVHVKSLPNV-----KCRHHDVDCIIIREQTEGEYSA---LEHESVPGVVEC-LKIITA 155
NV K LP + C D+D +I+RE +EGEYS H +P V + I T
Sbjct: 103 NVRPTKILPGITPPLRNCGPGDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTR 162
Query: 156 AKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVD 335
RI ++AF A RK +T V K+N + G ++ E+A +P + ++KM+VD
Sbjct: 163 VGVTRIMRYAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVD 222
Query: 336 NCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
T++M P D +V NL+ +I+ +
Sbjct: 223 AMTVRMTLKPETLDTIVATNLHADILSD 250
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 74.5 bits (175), Expect = 1e-12
Identities = 47/135 (34%), Positives = 75/135 (55%), Gaps = 4/135 (2%)
Frame = +3
Query: 27 PNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKS----ERIAKFAFDY 194
P KC ++D +++RE +EGEYS + G E I +A S ER+ ++AF+
Sbjct: 118 PLKKC---EIDVLVVRENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFE- 173
Query: 195 AVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQF 374
A + R VT K+N MK G L+ E +A YP + EK +D + ++V NP++F
Sbjct: 174 ASRKRRNHVTLATKSNAMKFGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKF 233
Query: 375 DVMVTPNLYGNIVDN 419
DV+V NL+ +I+ +
Sbjct: 234 DVIVGSNLFCDIISD 248
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 74.5 bits (175), Expect = 1e-12
Identities = 43/127 (33%), Positives = 70/127 (55%), Gaps = 4/127 (3%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHESVPGV----VECLKIITAAKSERIAKFAFDYAVKMGRKK 218
D+D +I+RE TEGEYSA+ G V + T +ER+ KFAF+ A + K+
Sbjct: 127 DIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRA-KR 185
Query: 219 VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNL 398
+T K+N + + + EMA YP + ++K +D + V P++FDV+V NL
Sbjct: 186 LTVATKSNGIAISMPWWDARAAEMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNL 245
Query: 399 YGNIVDN 419
+G+I+ +
Sbjct: 246 FGDILSD 252
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 74.1 bits (174), Expect = 2e-12
Identities = 45/122 (36%), Positives = 69/122 (56%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVH 233
V+ I RE +E Y +E E +++IT SERIA+ A K G K+T VH
Sbjct: 106 VNFTIYRENSEDLYMGIE-EITGDEARSVRVITRKASERIARAACS---KPGIGKLTIVH 161
Query: 234 KANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIV 413
K+N++K D LF +C ++AK + FE M+VD +V P +FD +VT N++G+I+
Sbjct: 162 KSNVLK-ADELFKDACAQVAKSM-NVPFEDMLVDTTAYNLVRAPEKFDTIVTTNMFGDIL 219
Query: 414 DN 419
+
Sbjct: 220 SD 221
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 73.3 bits (172), Expect = 3e-12
Identities = 37/122 (30%), Positives = 62/122 (50%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVH 233
+DC+I+RE TEG YS + + G E + + + ++A R+ V V
Sbjct: 137 IDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAARRSVCLVD 196
Query: 234 KANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIV 413
KAN ++ G L+ R E +P I + VD +++ ++P FDV+VT N YG+I+
Sbjct: 197 KANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGDIL 256
Query: 414 DN 419
+
Sbjct: 257 SD 258
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 72.9 bits (171), Expect = 4e-12
Identities = 46/124 (37%), Positives = 75/124 (60%), Gaps = 5/124 (4%)
Frame = +3
Query: 57 DCIIIREQTEGEYSALEHE--SVP-GVVECLKIITAAKSE--RIAKFAFDYAVKMGRKKV 221
D I IRE T G Y A + + P G+ + +T +++E RI + F+ A K +KK+
Sbjct: 129 DFIFIRELTGGVYFAKPKKRWTTPAGIRKATDSMTYSENEIERIVRVGFELA-KNRKKKL 187
Query: 222 TAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLY 401
+V KAN++ L L+ + E+AK YP ++ E ++VD C M+++ P FDV+VT NL+
Sbjct: 188 VSVDKANVL-LSSRLWRQIVIEVAKDYPEVKVEHVLVDACAMKLILAPTYFDVIVTENLF 246
Query: 402 GNIV 413
G+I+
Sbjct: 247 GDIL 250
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 72.5 bits (170), Expect = 6e-12
Identities = 44/123 (35%), Positives = 71/123 (57%), Gaps = 1/123 (0%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGR-KKVTAV 230
VD +++RE T G Y +H + +A++ RI + AF A+ GR KKVT++
Sbjct: 125 VDFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAF--AIARGRSKKVTSI 181
Query: 231 HKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNI 410
K N++ L+ + EE+AK Y + E +VD+ M M++NP FDV+VT NL+G+I
Sbjct: 182 DKQNVLATSK-LWRQIAEEVAKEYSDVTLEHQLVDSAAMVMITNPACFDVVVTENLFGDI 240
Query: 411 VDN 419
+ +
Sbjct: 241 LSD 243
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 71.7 bits (168), Expect = 1e-11
Identities = 45/136 (33%), Positives = 73/136 (53%), Gaps = 5/136 (3%)
Frame = +3
Query: 27 PNVKCRHHDVDCIIIREQTEGEYSALEHESVPGV-VECLKIITAAKSERIAKFAFDYAVK 203
P V +D ++IRE TEG ++++ V +IT SER+ +F+F A +
Sbjct: 128 PIVGADTRGIDLVVIRESTEGLFASMGKGVVTHEDARETMVITRRTSERLFEFSFRLAAR 187
Query: 204 M-GRKK---VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQ 371
R K +T V KAN+ K F +E+AK +P ++ +++ VD C+ +V P
Sbjct: 188 RKARGKPGMLTCVDKANVFK-AFAFFRGIFDEIAKKHPEVRTDRLYVDACSAMLVKRPWD 246
Query: 372 FDVMVTPNLYGNIVDN 419
FDVMV N++G+IV +
Sbjct: 247 FDVMVMENMFGDIVSD 262
>UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Francisella tularensis|Rep: 3-isopropylmalate
dehydrogenase - Francisella tularensis subsp. novicida
(strain U112)
Length = 359
Score = 71.3 bits (167), Expect = 1e-11
Identities = 36/79 (45%), Positives = 52/79 (65%)
Frame = +3
Query: 183 AFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSN 362
AF+ A + + +T+V KAN++ L+ E+AK YP ++ M VDNC MQMV N
Sbjct: 178 AFERATQRSNR-LTSVDKANVLDTSR-LWRNIVNEVAKDYPSVKVNHMYVDNCAMQMVLN 235
Query: 363 PNQFDVMVTPNLYGNIVDN 419
P+QFDVMVT NL+G+I+ +
Sbjct: 236 PSQFDVMVTGNLFGDIISD 254
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 71.3 bits (167), Expect = 1e-11
Identities = 41/122 (33%), Positives = 66/122 (54%), Gaps = 2/122 (1%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVH 233
+DC+ RE TEG Y+ +E + ++ IT S R+ A D+A K KK+ AV
Sbjct: 115 LDCVCFREATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVT 174
Query: 234 KANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFD--VMVTPNLYGN 407
K NI+K DG+F ++ + I+ ++ +DN QMV QF+ V+V+ NL+ +
Sbjct: 175 KRNILKQTDGIFWDETQKAVE-GTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNLFMD 233
Query: 408 IV 413
I+
Sbjct: 234 II 235
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 70.5 bits (165), Expect = 2e-11
Identities = 46/134 (34%), Positives = 76/134 (56%), Gaps = 4/134 (2%)
Frame = +3
Query: 30 NVKCRHHDVDCIIIREQTEGEYSALE--HESVPGVVECLKIITAAKSE--RIAKFAFDYA 197
++ R DV C+ RE T G Y + E + ++ E RIA+ AF+ A
Sbjct: 124 DISARGFDVLCV--RELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFE-A 180
Query: 198 VKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFD 377
+ RKKVT+V KAN++ L+ + EE+A +P ++ E + +DN TMQ++ P++FD
Sbjct: 181 ARGRRKKVTSVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFD 239
Query: 378 VMVTPNLYGNIVDN 419
VM+ NL+G+I+ +
Sbjct: 240 VMLCSNLFGDILSD 253
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 70.1 bits (164), Expect = 3e-11
Identities = 44/127 (34%), Positives = 71/127 (55%), Gaps = 5/127 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEY-----SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKK 218
VD +I+RE T G Y +E+ V +I A + +RIA+ AF+ A K R K
Sbjct: 172 VDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKR-RGK 230
Query: 219 VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNL 398
+ +V KAN++ L+ + +A YP ++ M VDN MQ++ +P QFD +VT N+
Sbjct: 231 LCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNI 289
Query: 399 YGNIVDN 419
+G+I+ +
Sbjct: 290 FGDILSD 296
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 69.7 bits (163), Expect = 4e-11
Identities = 42/127 (33%), Positives = 71/127 (55%), Gaps = 4/127 (3%)
Frame = +3
Query: 51 DVDCIIIREQTEGEY---SALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKM-GRKK 218
++D +++RE TEG + A+ L+I T + SER+ + AF+ A + G+K
Sbjct: 126 EIDFVLVRESTEGLFYGRDAIADLEADEATNLLRI-TRSASERVCRLAFETARRRDGKKT 184
Query: 219 VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNL 398
VT + KAN++ F +E+AK + I+ E + VD + +V P FDVMVT N+
Sbjct: 185 VTLIDKANVLS-SMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFDVMVTENM 243
Query: 399 YGNIVDN 419
+G+I+ +
Sbjct: 244 FGDILSD 250
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 68.9 bits (161), Expect = 7e-11
Identities = 47/131 (35%), Positives = 69/131 (52%), Gaps = 11/131 (8%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPG----VVECLKIITAAKSERIAKFAFDY-------AV 200
VD +IIRE TEG Y+ + PG V ++IT E++ + AF+ A
Sbjct: 122 VDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAP 181
Query: 201 KMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDV 380
K G+ +VTA+ K N++ G LF E+ YP I+ + IVD T +V P +DV
Sbjct: 182 KDGKLRVTAIIKDNVLH-GCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYDV 240
Query: 381 MVTPNLYGNIV 413
VT N++G+IV
Sbjct: 241 CVTSNMFGDIV 251
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 67.3 bits (157), Expect = 2e-10
Identities = 43/127 (33%), Positives = 70/127 (55%), Gaps = 5/127 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLK-IITAAKSE----RIAKFAFDYAVKMGRKK 218
+D +++RE T G Y + + T A SE RIA+ AF+ A K R+K
Sbjct: 136 IDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAEVDRIARVAFELARKR-RRK 194
Query: 219 VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNL 398
+ +V KAN++++ L+ +A YP ++ + VDN MQ+V P QFDV++T NL
Sbjct: 195 LCSVDKANVLEVSQ-LWRERVTAIAAEYPDVELSHLYVDNAAMQLVRWPKQFDVILTENL 253
Query: 399 YGNIVDN 419
+G+I+ +
Sbjct: 254 FGDILSD 260
>UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Helicobacter hepaticus
Length = 357
Score = 67.3 bits (157), Expect = 2e-10
Identities = 43/126 (34%), Positives = 71/126 (56%), Gaps = 4/126 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEH--ESVPG--VVECLKIITAAKSERIAKFAFDYAVKMGRKKV 221
+D II+RE G Y EH E + G V +A++ E IAK AF+ A + +K++
Sbjct: 129 IDFIIVRELIGGVYFG-EHKLEEINGEKVASDAMTYSASQIESIAKVAFNIA-RNRKKEI 186
Query: 222 TAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLY 401
V KAN++ L+ +++A+ Y + M VDN MQ+ P+QFDV++T N++
Sbjct: 187 VCVDKANVLS-SSRLWREVVDKVAQNYKDVHLSYMYVDNAAMQICRAPSQFDVILTENMF 245
Query: 402 GNIVDN 419
G+I+ +
Sbjct: 246 GDILSD 251
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 66.9 bits (156), Expect = 3e-10
Identities = 49/151 (32%), Positives = 72/151 (47%), Gaps = 22/151 (14%)
Frame = +3
Query: 27 PNVKCRHHDVDCIIIREQTEGEYSALEHE---SVPGVVECLK-IITAAKSERIAKFAFDY 194
P + D+D +++RE + G Y+ + P V C I T ++ +R KFAF+
Sbjct: 116 PLANKKPEDIDYVVVRENSGGVYTGMGGNVQIDTPEEVACQNWIYTRSQVDRCLKFAFEL 175
Query: 195 AVKMGRKK------------------VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFE 320
A K K+ +T V K N++ GL+ R+ MAK YP ++
Sbjct: 176 AEKRHTKENPWRGLSEEDKKAGYTSQLTLVGKTNVLTYVCGLWERAFNAMAKNYPTVKTA 235
Query: 321 KMIVDNCTMQMVSNPNQFDVMVTPNLYGNIV 413
VD TM MV NP FDV+VT NL G+I+
Sbjct: 236 YCHVDAATMWMVKNPEWFDVVVTENLMGDII 266
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 65.3 bits (152), Expect = 8e-10
Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 11/146 (7%)
Frame = +3
Query: 15 VKSLPNVK---CRHHDVDCIIIREQTEGEYS----ALEHESVPGVVECLKIITAAKSERI 173
+KSLP + +D+D +I RE EGEYS L + + I+T E+I
Sbjct: 107 IKSLPGISSPLAGGNDIDFVIFRENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKI 166
Query: 174 AKFAFDYAVKMGRKKVTAVHKANI----MKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNC 341
+ A +YA + G+ K+T+ K+N MK D ++ ++A P +Q E + +D
Sbjct: 167 VRAACEYAQQHGKTKLTSATKSNAIIHSMKFWDEYTRKTVTQIA---PELQLEAIYIDAL 223
Query: 342 TMQMVSNPNQFDVMVTPNLYGNIVDN 419
V P +F+V+V NL+G+I+ +
Sbjct: 224 VAYFVERPQEFEVVVASNLFGDILSD 249
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 64.9 bits (151), Expect = 1e-09
Identities = 34/119 (28%), Positives = 57/119 (47%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQF 317
++IIT ++RI + AF +A K K VT K N+++ G+ +++ K YP I
Sbjct: 188 VRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQYPEIAL 247
Query: 318 EKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDNXXXXXXXXXXXXXXXXXXXECAVFE 494
+D TM + NP ++ V+V NL+G+++ + E AVFE
Sbjct: 248 WSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAASGNIGDEVAVFE 306
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 64.5 bits (150), Expect = 1e-09
Identities = 44/146 (30%), Positives = 74/146 (50%)
Frame = +3
Query: 57 DCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVHK 236
+ +I+RE TEG Y+ ++ +IIT + RIAKFA + A K +T VHK
Sbjct: 106 EIVIVRENTEGLYARDGIGFSDRAID-FRIITLEGARRIAKFAINLA-KERNSFITFVHK 163
Query: 237 ANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVD 416
AN++K GD F E+A+ ++ + I+D+ +++V NP V++T N++G+I+
Sbjct: 164 ANVLK-GDRFFREIVLEIAER-EGVEVREAIIDSFMIKLVKNPWDHGVILTENMFGDIIS 221
Query: 417 NXXXXXXXXXXXXXXXXXXXECAVFE 494
+ E A+FE
Sbjct: 222 DLATIHAGSIGIVPSGNYGDEIALFE 247
>UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 351
Score = 62.9 bits (146), Expect = 4e-09
Identities = 37/123 (30%), Positives = 70/123 (56%), Gaps = 1/123 (0%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVH 233
VD +I+RE G Y + + T + ER+A+ AF +A + R +VT+V
Sbjct: 126 VDILIVRELLGGIYFDGDRKIEGDTAYNTMRYTTPEVERVARVAF-WAAEQRRGRVTSVD 184
Query: 234 KANIMKLGDGLFLRSCEEMA-KLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNI 410
KAN++++ + L+ R + + + Y + VD+ M +V+NP+++DV++T NL+G+I
Sbjct: 185 KANVLEVSE-LWRRDVQALRDREYRNVHLNHEYVDSVAMLIVANPSRYDVILTENLFGDI 243
Query: 411 VDN 419
+ +
Sbjct: 244 LSD 246
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 62.1 bits (144), Expect = 8e-09
Identities = 30/92 (32%), Positives = 55/92 (59%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQF 317
L +++ ++RI +++FD A +K +++V KAN++ G + + A YP ++
Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239
Query: 318 EKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIV 413
+ VD TM V NP FDV+V+PN++G+I+
Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDII 271
>UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Candidatus Carsonella ruddii PV|Rep: 3-isopropylmalate
dehydrogenase - Carsonella ruddii (strain PV)
Length = 349
Score = 61.3 bits (142), Expect = 1e-08
Identities = 34/137 (24%), Positives = 74/137 (54%), Gaps = 8/137 (5%)
Frame = +3
Query: 33 VKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECL--------KIITAAKSERIAKFAF 188
+KC ++D II+RE G Y ++ + KI + R+A+ +F
Sbjct: 104 IKCPFKNIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISF 163
Query: 189 DYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPN 368
+ A+ +KK+ ++ K+N+++ L+ ++ + K Y +++ + +D T+ ++ N N
Sbjct: 164 NLALNR-KKKLCSIDKSNVLETFK-LWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFN 221
Query: 369 QFDVMVTPNLYGNIVDN 419
+FDV++T NL+G+I+ +
Sbjct: 222 KFDVIITSNLFGDIISD 238
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 59.7 bits (138), Expect = 4e-08
Identities = 44/149 (29%), Positives = 73/149 (48%), Gaps = 10/149 (6%)
Frame = +3
Query: 3 NVVHVKSLPNVKC--RHHDVDCIIIREQTEGEYSALEHESVPGVVECLK--IITAAKSER 170
NV + LP V R VD +I+RE TEG Y + V C ++T ER
Sbjct: 107 NVRPIALLPGVDAPLRGTAVDYVIVRENTEGLYLS-RGRGVGNDRACADQLLMTRHGVER 165
Query: 171 IAKFAFDYAVKM------GRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIV 332
+ AF+ A + G ++VT V K+N+++ F +E+A YP+++ +
Sbjct: 166 VVVHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYA 224
Query: 333 DNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
D +V++P +FDV+V N G+I+ +
Sbjct: 225 DAAGHDLVADPGRFDVLVMENFLGDILSD 253
>UniRef50_A0FP11 Cluster: Isocitrate/isopropylmalate dehydrogenase
precursor; n=1; Burkholderia phymatum STM815|Rep:
Isocitrate/isopropylmalate dehydrogenase precursor -
Burkholderia phymatum STM815
Length = 253
Score = 59.7 bits (138), Expect = 4e-08
Identities = 31/87 (35%), Positives = 52/87 (59%)
Frame = +3
Query: 159 KSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDN 338
++ R + AF A K G KK+T+V KAN+++ + +++K Y ++ M VDN
Sbjct: 77 RTRRASHVAFQAAQKRG-KKLTSVDKANVLETSQ-FWKDIMIDVSKEYADVELSHMYVDN 134
Query: 339 CTMQMVSNPNQFDVMVTPNLYGNIVDN 419
MQ+V P FDV+VT N++G+I+ +
Sbjct: 135 AAMQLVKAPKSFDVIVTGNMFGDILSD 161
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 59.7 bits (138), Expect = 4e-08
Identities = 45/131 (34%), Positives = 70/131 (53%), Gaps = 9/131 (6%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVP---GVVECL--KIITAAKSERIAKFAFDYAVKMGRKK 218
+D +I+RE T G Y E + G + ++ + ERIA AF+ A + R K
Sbjct: 129 LDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFELA-RTRRNK 187
Query: 219 VTAVHKANIMKLG----DGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMV 386
VT++ K N+MK G G+ R E+ A +Q E M+ D MQ+V P QFDV++
Sbjct: 188 VTSMEKRNVMKSGVLWNQGVTARHKEKHAD----VQLEHMLADAGGMQLVRWPKQFDVIL 243
Query: 387 TPNLYGNIVDN 419
T NL+G+++ +
Sbjct: 244 TDNLFGDLLSD 254
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 59.3 bits (137), Expect = 5e-08
Identities = 39/123 (31%), Positives = 70/123 (56%), Gaps = 4/123 (3%)
Frame = +3
Query: 57 DCIIIREQTEGEYSALEHESVPGVVE-CLKIITAAKSE--RIAKFAFDYAVKMGRKKVTA 227
D + RE T G Y S G E + +T + E RI + A A + ++T+
Sbjct: 129 DILFFRELTGGIYFGESGTSGSGEEETAFQSMTYSVGEVKRIVRMAAQ-AARGRSNRLTS 187
Query: 228 VHKANIMKLGDGLFLR-SCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYG 404
V KAN+++ L+ R + E MA +P +Q++ ++VD+ M +++ P++FDV+VT N++G
Sbjct: 188 VDKANVLE-PSRLWRRVAAEVMANEFPDVQYDVVLVDSMAMHLINRPSEFDVVVTGNMFG 246
Query: 405 NIV 413
+I+
Sbjct: 247 DIL 249
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 58.8 bits (136), Expect = 7e-08
Identities = 42/129 (32%), Positives = 71/129 (55%), Gaps = 6/129 (4%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEH--ESVPGVVEC---LKIITAAKSERIAKFAFDYAVKMGRK 215
DVD IIIRE T G Y E++P + T ++ R+A+ AF+ A + +
Sbjct: 132 DVDFIIIRELTSGIYFGEPRGIETLPDGQRRGFNTQQYTTSQIRRVARTAFELA-RTRKG 190
Query: 216 KVTAVHKANIMKLGDGLFLRSCEEMAKL-YPRIQFEKMIVDNCTMQMVSNPNQFDVMVTP 392
+V +V KAN+++ L+ + + + ++ + VDN MQ+V P+QFDVMVT
Sbjct: 191 RVCSVDKANVLETSV-LWREEVTALHEAEFSDVELTHLYVDNAAMQIVRAPSQFDVMVTC 249
Query: 393 NLYGNIVDN 419
N++G+I+ +
Sbjct: 250 NIFGDILSD 258
>UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Psychromonas ingrahamii 37|Rep: 3-isopropylmalate
dehydrogenase - Psychromonas ingrahamii (strain 37)
Length = 368
Score = 58.4 bits (135), Expect = 1e-07
Identities = 42/128 (32%), Positives = 66/128 (51%), Gaps = 6/128 (4%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPG-----VVECLKIITAAKSERIAKFAFDYAVKMGRKK 218
+D +IIRE G Y + V V E L+ + +I K F+ V M RKK
Sbjct: 134 IDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEY-DEDQIRQIVKVGFE--VSMKRKK 190
Query: 219 VTA-VHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPN 395
V +HK+N++K L+ EE +K YP ++ + ++VD + NP FDVMV N
Sbjct: 191 VMHNIHKSNVLK-SSVLWNEIVEEESKNYPEVEVKNILVDAAATYLCLNPGMFDVMVMEN 249
Query: 396 LYGNIVDN 419
++G+I+ +
Sbjct: 250 MFGDILSD 257
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 58.4 bits (135), Expect = 1e-07
Identities = 42/125 (33%), Positives = 64/125 (51%), Gaps = 3/125 (2%)
Frame = +3
Query: 54 VDCIIIREQTEGEY--SALEHESVPGVVECLKIITAAKS-ERIAKFAFDYAVKMGRKKVT 224
+D ++IRE G Y SA G ++ R+A+ A A + R K+T
Sbjct: 180 LDILVIRELVSGIYFGSAGRASDEKGAYGYHTMLYYDHEIRRLARQALQKA-QQRRGKLT 238
Query: 225 AVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYG 404
HK N L + + R +E A +P + E M+VDN MQMV NP +FDV++ NL+G
Sbjct: 239 VAHKENA--LPNLPWTRLVQEEAAQFPDVIVEPMLVDNLAMQMVMNPQRFDVILASNLFG 296
Query: 405 NIVDN 419
+I+ +
Sbjct: 297 DILSD 301
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 58.0 bits (134), Expect = 1e-07
Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 27/135 (20%)
Frame = +3
Query: 171 IAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLY---------------- 302
I +AF YAV R+ VT++ KANIMK DGL+ +AK Y
Sbjct: 174 ICNYAFKYAVDNKRQSVTSICKANIMKFTDGLWYDETRAVAKAYGAKFEWDELSEGVEAD 233
Query: 303 PRI-----------QFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDNXXXXXXXXXX 449
P++ ++ + ++DN MQ+V P +DV+VT NLYG+I+ +
Sbjct: 234 PKLAGIATDCGGSIEYNERLIDNMCMQLVQKPELYDVLVTSNLYGDILSDLCAGLVGGLG 293
Query: 450 XXXXXXXXXECAVFE 494
E A+FE
Sbjct: 294 VAPGSNIGTEAAIFE 308
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 58.0 bits (134), Expect = 1e-07
Identities = 26/71 (36%), Positives = 42/71 (59%)
Frame = +3
Query: 18 KSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYA 197
+S P KCR VD +I + G ++ LE+ V GVVE L +++ +++ ++AF A
Sbjct: 148 RSFPGFKCRFPGVDIQLIGQNNMGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAA 207
Query: 198 VKMGRKKVTAV 230
K GRK+VT +
Sbjct: 208 AKAGRKRVTLI 218
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 57.6 bits (133), Expect = 2e-07
Identities = 41/129 (31%), Positives = 64/129 (49%), Gaps = 8/129 (6%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALE---HESVPG-VVECLKIITAAKSERIAKFAFDYAVKMGRKK 218
DV+ + IRE TEGEYS + H +P VV + T +ERI ++A+ A RK+
Sbjct: 124 DVNFVCIRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPRKR 183
Query: 219 VTAVHKAN----IMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMV 386
+ K+N M D +F E + +P + +D V P++FDV+V
Sbjct: 184 LCGATKSNGINYTMPYWDEIFNEIGE---REFPEVNRWLCHIDALAANFVLKPDEFDVVV 240
Query: 387 TPNLYGNIV 413
NL+G+I+
Sbjct: 241 ASNLFGDIL 249
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 56.8 bits (131), Expect = 3e-07
Identities = 26/94 (27%), Positives = 54/94 (57%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQF 317
L++ + + R+ FAF +A++ G +VT K N+++ + E A+ YP+IQ
Sbjct: 174 LRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQA 233
Query: 318 EKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
+ + VD + ++ +P +F V+V N++G+I+ +
Sbjct: 234 DILNVDAVALWLIKSPEKFGVIVAENMFGDILSD 267
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 56.4 bits (130), Expect = 4e-07
Identities = 36/141 (25%), Positives = 66/141 (46%), Gaps = 3/141 (2%)
Frame = +3
Query: 6 VVH--VKSLPNVKCRHHD-VDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIA 176
V+H V ++P ++ +++ + I+R T G Y ++ I S +
Sbjct: 95 VIHRPVATIPGIQTHYNERIHLDIVRIATGGTYEDAGRRINRDTAVSIRAIERRPSVLAS 154
Query: 177 KFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMV 356
+FAF A ++ V A K I K DGLF + +A+ YP +F + + D ++
Sbjct: 155 RFAFRLA-QLRDSNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGII 213
Query: 357 SNPNQFDVMVTPNLYGNIVDN 419
P ++ V+V PN YG+ + +
Sbjct: 214 MRPERYGVIVCPNEYGDFLSD 234
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 56.0 bits (129), Expect = 5e-07
Identities = 43/142 (30%), Positives = 65/142 (45%), Gaps = 23/142 (16%)
Frame = +3
Query: 57 DCIIIREQTEGEYSALEHESVPGV----VECLKIITAAKSERIAKFAFDYAVKMGRKK-- 218
D ++IRE +EGEY G L++ T A +ERI + AF+ A + ++
Sbjct: 135 DLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAFERAARRAEERRQ 194
Query: 219 -----------------VTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTM 347
V V K N ++ L+ E+A YP I ++D C M
Sbjct: 195 GLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPGIATHHELIDACCM 254
Query: 348 QMVSNPNQFDVMVTPNLYGNIV 413
+ VS P QFDV+V NL+G+I+
Sbjct: 255 KFVSQPWQFDVVVASNLHGDIL 276
>UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Leuconostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 357
Score = 54.0 bits (124), Expect = 2e-06
Identities = 34/123 (27%), Positives = 57/123 (46%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAV 230
+ D +I+RE T G Y + + + RI F A K K VT V
Sbjct: 127 NTDFVIVRELTSGAYFGKPRKLEAHQAIDTMYYSEEEVTRIMHQGFKMAQKRN-KHVTIV 185
Query: 231 HKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNI 410
K+N++ + + E+ K Y + + VD TM +++ P FDV++ PNL+G+I
Sbjct: 186 DKSNVLATSK-FWRKIANEVGKSYQDVTIDYYYVDAMTMAIMAKPTTFDVVIIPNLFGDI 244
Query: 411 VDN 419
+ +
Sbjct: 245 LSD 247
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 54.0 bits (124), Expect = 2e-06
Identities = 37/111 (33%), Positives = 55/111 (49%), Gaps = 19/111 (17%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKL-YPRIQ 314
+K I+ SER+ +FA ++A+ R VT VHK N++K DG F R +AK + I+
Sbjct: 199 IKNISKEGSERLTRFALNFALNNNRDSVTFVHKGNVLKFTDGAFKRWGFALAKKEFNAIE 258
Query: 315 FE------------------KMIVDNCTMQMVSNPNQFDVMVTPNLYGNIV 413
E ++I DN Q + NP QFDV+ T N G+ +
Sbjct: 259 HENGRWLKIERAGQAPLIIKEVIADNMLQQCLMNPEQFDVVATTNQNGDFL 309
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 53.2 bits (122), Expect = 4e-06
Identities = 28/104 (26%), Positives = 57/104 (54%), Gaps = 10/104 (9%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLR-----SCEEMAKLY 302
+K ++ K++RI + A YA+ KK+T +HK N+MK +G F + E +
Sbjct: 180 IKPMSRYKTQRITRLAVKYAMDNNLKKITIMHKGNVMKYTEGAFREWAYETALNEFSDYV 239
Query: 303 PRIQFEKMIV-----DNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
R +K+I+ DN Q+++ P+++ +++ PN+ G+ + +
Sbjct: 240 SRDDDKKIIINDIIADNMFQQIITRPDEYQLILAPNVDGDYISD 283
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 52.4 bits (120), Expect = 6e-06
Identities = 44/149 (29%), Positives = 74/149 (49%), Gaps = 14/149 (9%)
Frame = +3
Query: 15 VKSLPNVKCRHHD-----VDCIIIREQTEG-EYSALEHESVPGV----VECLKIITAAKS 164
VK+ PN R D +D +I+RE TEG YSA H+ V V+ + IT +
Sbjct: 105 VKAYPNAPQRLADPRAAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTT 164
Query: 165 ERIAKFAFDYAVKMGRK----KVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIV 332
++ +FAF+ A K + ++T V KAN+ F + +E+ + + V
Sbjct: 165 TKLHRFAFNLARKRRERGHPGRLTCVDKANVF-TSLAFFRQIFDEVKSEFADVPVGYNYV 223
Query: 333 DNCTMQMVSNPNQFDVMVTPNLYGNIVDN 419
D + +V P +FDV+V N++G+I+ +
Sbjct: 224 DAQALDLVRKPWEFDVLVMENMFGDILSD 252
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 47.6 bits (108), Expect = 2e-04
Identities = 50/181 (27%), Positives = 79/181 (43%), Gaps = 43/181 (23%)
Frame = +3
Query: 6 VVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSE------ 167
V ++K +P+ V+ +I RE TE Y+ +E G E LK+I K+E
Sbjct: 127 VYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPR--GSEEALKLIRFLKNEFGVTIR 184
Query: 168 ----------------RIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAK- 296
R+ + A YA++ RK VT VHK NIMK +G F E+AK
Sbjct: 185 EDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQ 244
Query: 297 -----------LYP---------RIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVD 416
L+ +I + I DN Q+++ +++DV+ PNL G+ +
Sbjct: 245 EFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLS 304
Query: 417 N 419
+
Sbjct: 305 D 305
>UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=3; Aquificaceae|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Aquifex aeolicus
Length = 426
Score = 46.8 bits (106), Expect = 3e-04
Identities = 37/133 (27%), Positives = 62/133 (46%), Gaps = 16/133 (12%)
Frame = +3
Query: 69 IREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIM 248
+RE E A E V +K ++ K++R + A YA++ +K V + K NIM
Sbjct: 184 VREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIM 243
Query: 249 KLGDGLFLRSCEEMA-------------KLYP---RIQFEKMIVDNCTMQMVSNPNQFDV 380
K +G F+ E+A + P +++ K+I D MQ+V P +DV
Sbjct: 244 KATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDV 303
Query: 381 MVTPNLYGNIVDN 419
++ NL G+ V +
Sbjct: 304 IIAQNLNGDYVSD 316
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 46.0 bits (104), Expect = 5e-04
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 23/107 (21%)
Frame = +3
Query: 18 KSLPNVKCRHHDVDCIIIREQTEGEYSALEHES----VPGVVECL--------------- 140
K +P+ R DVD +I RE TE Y+ +E + V V++ L
Sbjct: 125 KGVPSPVKRPEDVDMVIFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETS 184
Query: 141 ----KIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLF 269
K ++ +ER+ + A YA+ RK VT VHK NIMK +G F
Sbjct: 185 GIGIKPVSKEGTERLVRAAIQYALDNNRKSVTLVHKGNIMKFTEGSF 231
>UniRef50_Q0A635 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Alkalilimnicola ehrlichei MLHE-1|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Alkalilimnicola ehrlichei (strain MLHE-1)
Length = 382
Score = 43.6 bits (98), Expect = 0.003
Identities = 32/122 (26%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Frame = +3
Query: 57 DCIIIREQTEGEYSALEHESVPGVVECLKIIT---AAKSERIAKFAFDYAVKMGRKKVTA 227
D +I+RE G Y G + A + ERI + A A + R +
Sbjct: 146 DVLIVRENASGLYCGEWGSEGEGAARSAYQVCRYRADEVERILRTALRLAGQR-RGDLVV 204
Query: 228 VHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGN 407
V K + L+ + +A + ++ + VDN Q++++P QFDV+V PN++G+
Sbjct: 205 VTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGD 264
Query: 408 IV 413
I+
Sbjct: 265 IL 266
>UniRef50_P56472 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit beta,
mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase)
(NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 103
Score = 42.3 bits (95), Expect = 0.007
Identities = 18/35 (51%), Positives = 26/35 (74%)
Frame = +3
Query: 204 MGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPR 308
+G + + AV +KLGDGLFL+ CEE+A+LYP+
Sbjct: 25 VGPELMAAVGVIECLKLGDGLFLQCCEEVAELYPK 59
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 41.9 bits (94), Expect = 0.009
Identities = 23/76 (30%), Positives = 40/76 (52%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQF 317
+K I+ +ER+ + A +YA+ + VT VHK NIMK +G F++ +A+ +F
Sbjct: 207 VKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK----EF 262
Query: 318 EKMIVDNCTMQMVSNP 365
++D + NP
Sbjct: 263 NAQVIDKGPWCSLKNP 278
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 41.5 bits (93), Expect = 0.012
Identities = 32/138 (23%), Positives = 59/138 (42%), Gaps = 19/138 (13%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLY----- 302
+K ++ ++R+ + A Y + RK +T VHK NIMK +G F ++A+ +
Sbjct: 198 IKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGAFKEWGYQVAQEFGAELL 257
Query: 303 ----------PR----IQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIVDNXXXXXXX 440
P+ I + I D +++ +P ++DV+ T NL G+ + +
Sbjct: 258 DGGPWMTLKNPKTGREIIIKDSIADAFLQEILLHPTEYDVIATLNLNGDYISDALAAQVG 317
Query: 441 XXXXXXXXXXXXECAVFE 494
E A+FE
Sbjct: 318 GIGISPGANIGAEAAIFE 335
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 41.1 bits (92), Expect = 0.016
Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 3/75 (4%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGVVECLKI---ITAAKSERI 173
NV+H +SLP V+ RH ++D III E++ E+SAL E+ VE L++ + ++R
Sbjct: 141 NVMHCQSLPGVQTRHKNIDIIIILEKS--EFSALLAENEKIKVELLQLRIQLADVINKRR 198
Query: 174 AKFAFDYAVKMGRKK 218
A D ++ R K
Sbjct: 199 ADIILDLNIEKSRVK 213
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 40.7 bits (91), Expect = 0.021
Identities = 20/44 (45%), Positives = 27/44 (61%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLF 269
+K I+ S+R+ + A DYA+ R VT VHK NIMK +G F
Sbjct: 240 VKPISEFGSKRLIREAIDYALANDRDSVTLVHKGNIMKFTEGAF 283
>UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Dikarya|Rep: 3-isopropylmalate dehydrogenase -
Phanerochaete chrysosporium (White-rot fungus)
(Sporotrichumpruinosum)
Length = 380
Score = 40.7 bits (91), Expect = 0.021
Identities = 32/127 (25%), Positives = 61/127 (48%), Gaps = 5/127 (3%)
Frame = +3
Query: 54 VDCIIIREQTEGEYSALEHESVPGVVECLK----IITAAKSERIAKFAFDYAVKMGRKKV 221
VD I+IRE G Y E E I + + +RI + A V
Sbjct: 132 VDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSRRQVASPDPPLPV 191
Query: 222 TAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFD-VMVTPNL 398
++ KAN++ + E + +P+++ + +VD+ +M +V+NP + + V++T NL
Sbjct: 192 HSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANPKKLNGVILTENL 251
Query: 399 YGNIVDN 419
+G+I+ +
Sbjct: 252 FGDILSD 258
>UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=2; Desulfitobacterium hafniense|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Desulfitobacterium hafniense (strain DCB-2)
Length = 374
Score = 39.9 bits (89), Expect = 0.036
Identities = 30/127 (23%), Positives = 58/127 (45%), Gaps = 6/127 (4%)
Frame = +3
Query: 51 DVDCIIIREQTEGEYSALEHESVPGVVECLKIITAAKSERIAKFAFDYAV------KMGR 212
++D +++R+ EG Y H ++T +E+ A F A + G+
Sbjct: 129 EIDVLLVRQLAEGFYIRPGHMIGEDAAYDTIVVTRNVTEKFADTCFRLARGRHGRRQDGK 188
Query: 213 KKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNCTMQMVSNPNQFDVMVTP 392
K VT +K + D + + E++ YP I + VD ++ +P++FDV+
Sbjct: 189 KMVTLGNKHGNVTCFD-FYRKIFTEVSAGYPDIGLQFTQVDALAEHLIKDPDRFDVIACE 247
Query: 393 NLYGNIV 413
N+ G+I+
Sbjct: 248 NMIGDII 254
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 39.9 bits (89), Expect = 0.036
Identities = 18/44 (40%), Positives = 26/44 (59%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLF 269
+K ++ +ER+ A YA+ R+ VT VHK NIMK +G F
Sbjct: 218 IKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTEGAF 261
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 39.9 bits (89), Expect = 0.036
Identities = 25/86 (29%), Positives = 39/86 (45%)
Frame = +3
Query: 162 SERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDNC 341
S R K F+ A + VT KAN +K+ + RS A + I D
Sbjct: 157 SYRYLKKFFNKAFSICDSTVTVTDKANAVKMYN--LWRSTAMEAAIEKNINISFEYADAL 214
Query: 342 TMQMVSNPNQFDVMVTPNLYGNIVDN 419
M+ NP ++ ++ PNLYG+I+ +
Sbjct: 215 AYNMILNPKKYRYIIAPNLYGDIISD 240
>UniRef50_A7CDA2 Cluster: Putative uncharacterized protein; n=2;
Ralstonia pickettii|Rep: Putative uncharacterized
protein - Ralstonia pickettii 12D
Length = 580
Score = 35.1 bits (77), Expect = 1.0
Identities = 34/103 (33%), Positives = 49/103 (47%)
Frame = -2
Query: 479 LRAVGSAGDDTGPANKSAGEVVYYVAVQVGRDHHVELVRVRYHLHRAVVHDHLLELDPGV 300
+R VG+ GD T AN + V VAVQV R HH L R + L + V + +L+ D
Sbjct: 81 IRQVGTRGD-TDTANLCSQGVGDVVAVQVQRCHHRVLGRTQQDLLQEGVGNRVLDDDFLA 139
Query: 299 QLRHLFTTPKEESIT*FHDVRLVDGGYLLTAHLDRVIESEFRD 171
+LR L P+ V + +LL + V E+ FR+
Sbjct: 140 RLRVLELAPRAA-------VDQLGAEFLLCQRVGPVTEATFRE 175
>UniRef50_Q0ZQ47 Cluster: FrbB; n=1; Streptomyces
rubellomurinus|Rep: FrbB - Streptomyces rubellomurinus
Length = 352
Score = 34.7 bits (76), Expect = 1.3
Identities = 26/96 (27%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Frame = +3
Query: 147 ITAAKSERIAKFAFDYAVKMGRK----KVTAVHKANIMKLGDGLF-LRSCEEMAKLYPR- 308
I A +R+++F AV M R+ + HK N +K DGLF L + E + L
Sbjct: 149 IQAIAPDRVSEFVRT-AVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAAETLESLAGAA 207
Query: 309 -IQFEKMIVDNCTMQMVSNPNQFDVMVTPNLYGNIV 413
I + +I+D+ ++V NP + ++T + + +++
Sbjct: 208 GIAWRSLIIDHMAAELVRNPLDYRAILTHSSFADLL 243
>UniRef50_A0HHB1 Cluster: Putative uncharacterized protein; n=1;
Comamonas testosteroni KF-1|Rep: Putative
uncharacterized protein - Comamonas testosteroni KF-1
Length = 423
Score = 34.7 bits (76), Expect = 1.3
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Frame = -2
Query: 494 FEDGT-LRAVGSAGDDTGPANKSAGEVVYYVAVQVGRDHHVELVRVRYHLHRAVVHDHLL 318
FE G LR +G+ G + PA+ + VAV+V R HH R +L + V D +L
Sbjct: 53 FEAGNALRQIGT-GSNADPAHLRGQRIRDVVAVEVERGHHRIFGRAHQNLLQEGVGDRVL 111
Query: 317 ELDPGVQLRHLFTTP 273
+ D +LR L P
Sbjct: 112 DDDVLARLRVLDAAP 126
>UniRef50_Q5CWJ8 Cluster: Predicted degraded Zn-finger +bbox Zn finger
protein; n=3; Cryptosporidium|Rep: Predicted degraded
Zn-finger +bbox Zn finger protein - Cryptosporidium
parvum Iowa II
Length = 1176
Score = 34.3 bits (75), Expect = 1.8
Identities = 20/84 (23%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Frame = +3
Query: 3 NVVHVKSLPNVKCRHHDVDCIIIREQTEGEYSALEHESVPGV--VECLKIITAAKSERIA 176
N K L + + HH++ I+ E EGEY + +P V + + ++A K++ +
Sbjct: 776 NNTREKLLISTQPDHHELTQTIVYEDDEGEYYEEQEIDLPDVMSIRLDRKLSAKKTKSLE 835
Query: 177 KFAFDYAVKMGRKKVTAVHKANIM 248
K +K+G++ V + K ++
Sbjct: 836 KLMIPSILKVGKEPVIQIEKLYVI 859
>UniRef50_Q5FUX9 Cluster: Putative uncharacterized protein; n=2;
Acetobacteraceae|Rep: Putative uncharacterized protein -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 460
Score = 33.1 bits (72), Expect = 4.1
Identities = 16/37 (43%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Frame = -2
Query: 512 YVPSALFEDGTLRAVGSAGDDTGPANKSAGEV-VYYV 405
+ A+ D TL +VGS G + PAN S G + V YV
Sbjct: 197 FASDAILNDATLLSVGSTGSNANPANTSLGRIGVGYV 233
>UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_03000731;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000731 - Ferroplasma acidarmanus fer1
Length = 377
Score = 32.7 bits (71), Expect = 5.4
Identities = 19/80 (23%), Positives = 39/80 (48%)
Frame = +3
Query: 159 KSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQFEKMIVDN 338
++ +IAK A Y+ + G+KK+T + + F C E A + +E +
Sbjct: 192 RTRKIAKQAVRYSRRNGKKKITILESQQNHE-----FANWCIEEASAQEDVGYEVLKTRE 246
Query: 339 CTMQMVSNPNQFDVMVTPNL 398
+++S+P F+V++ N+
Sbjct: 247 FMKRLISSPEDFEVILVDNV 266
>UniRef50_A5E1Q0 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 921
Score = 32.7 bits (71), Expect = 5.4
Identities = 22/80 (27%), Positives = 40/80 (50%)
Frame = +3
Query: 102 LEHESVPGVVECLKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSC 281
++ +VP +E L ++ A +ER AKFA +K GR + ++ K+ K +
Sbjct: 222 VQKNNVPSSIESLDLMDLAGAERDAKFA---DIKKGRLILASLRKSEPYKSSSWISSARL 278
Query: 282 EEMAKLYPRIQFEKMIVDNC 341
EE AK + + + +I+ C
Sbjct: 279 EEEAKCFDKAR--DLILQGC 296
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 32.7 bits (71), Expect = 5.4
Identities = 18/46 (39%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKK--VTAVHKANIMKLGDGLF 269
+K I+ S+R+ + A +A ++ + K VT VHK NIMK +G F
Sbjct: 203 IKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPF 248
>UniRef50_Q7QXK4 Cluster: GLP_36_20953_19154; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_36_20953_19154 - Giardia lamblia
ATCC 50803
Length = 599
Score = 32.3 bits (70), Expect = 7.2
Identities = 14/52 (26%), Positives = 23/52 (44%)
Frame = -2
Query: 248 HDVRLVDGGYLLTAHLDRVIESEFRDTFRFRSGDNLQALDHARHRLMFQSGV 93
HD+ D L+ H D + F T +R+ D + H L F++G+
Sbjct: 97 HDMDNADSAAFLSDHSDTLFGDRFISTNTYRNSDGAPLIQHTHKYLTFKNGI 148
>UniRef50_A4AFC1 Cluster: Transcription antiterminator, BglG family
protein; n=2; Actinobacteria (class)|Rep: Transcription
antiterminator, BglG family protein - marine
actinobacterium PHSC20C1
Length = 635
Score = 31.9 bits (69), Expect = 9.5
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 1/82 (1%)
Frame = -2
Query: 365 RVRYHLHRAVVHDHLLEL-DPGVQLRHLFTTPKEESIT*FHDVRLVDGGYLLTAHLDRVI 189
RVR R + D LL DP + LR+ FT P EE++ R+++ G + +++ I
Sbjct: 476 RVRRLRRRRTLTDELLRFFDPALFLRN-FTAPSEEAMIAALGHRMIEAGVIDHSYITGAI 534
Query: 188 ESEFRDTFRFRSGDNLQALDHA 123
E E + F D+L A+ HA
Sbjct: 535 ERERMSSTAFT--DSL-AVPHA 553
>UniRef50_A5E6C5 Cluster: ATP-dependent RNA helicase DOB1; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep:
ATP-dependent RNA helicase DOB1 - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 970
Score = 31.9 bits (69), Expect = 9.5
Identities = 20/71 (28%), Positives = 33/71 (46%)
Frame = +3
Query: 138 LKIITAAKSERIAKFAFDYAVKMGRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPRIQF 317
LK+ A SE+I F AV R K KA + KLG+ L E+ ++ +++F
Sbjct: 681 LKVAMADSSEKIVLLPFIQAVSSVRVKNANAIKAVVQKLGEVPLLIKDEKALEIQKKVEF 740
Query: 318 EKMIVDNCTMQ 350
+D ++
Sbjct: 741 LSSKLDKVVLE 751
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 526,895,730
Number of Sequences: 1657284
Number of extensions: 10716115
Number of successful extensions: 32946
Number of sequences better than 10.0: 120
Number of HSP's better than 10.0 without gapping: 31760
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 32858
length of database: 575,637,011
effective HSP length: 95
effective length of database: 418,195,031
effective search space used: 33873797511
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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