Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= I09A02NGRL0002_A15
(643 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 265 5e-70
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 256 3e-67
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 214 1e-54
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 204 1e-51
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 181 1e-44
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 180 3e-44
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 176 3e-43
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 175 1e-42
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 168 1e-40
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 166 5e-40
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 164 2e-39
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 162 7e-39
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 161 1e-38
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 161 1e-38
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 158 1e-37
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 157 2e-37
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 157 3e-37
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 157 3e-37
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 153 5e-36
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 152 6e-36
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 152 8e-36
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 151 1e-35
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 149 7e-35
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 148 1e-34
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 146 3e-34
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 146 4e-34
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 146 5e-34
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 144 1e-33
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 140 3e-32
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 140 3e-32
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 139 5e-32
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 137 2e-31
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 134 1e-30
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 134 2e-30
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 133 4e-30
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 132 5e-30
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 132 5e-30
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 129 5e-29
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 129 6e-29
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 128 9e-29
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 128 9e-29
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 128 1e-28
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 128 1e-28
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 126 3e-28
UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3; B... 126 5e-28
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 124 1e-27
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 124 2e-27
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 123 4e-27
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 123 4e-27
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 122 6e-27
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 122 6e-27
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 122 7e-27
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 121 1e-26
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 121 2e-26
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 120 4e-26
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 119 5e-26
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 119 7e-26
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 118 9e-26
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 118 9e-26
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 118 1e-25
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 118 2e-25
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 116 6e-25
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 116 6e-25
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 115 8e-25
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 113 3e-24
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 113 3e-24
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 113 5e-24
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 112 8e-24
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 111 1e-23
UniRef50_Q0LGT0 Cluster: Isocitrate/isopropylmalate dehydrogenas... 111 2e-23
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 110 2e-23
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 110 3e-23
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 109 4e-23
UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2; L... 108 1e-22
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 108 1e-22
UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2; H... 107 2e-22
UniRef50_Q2Q0B6 Cluster: Putative 3-isopropylmalate dehydrogenas... 105 7e-22
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 105 1e-21
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 105 1e-21
UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11; ... 104 2e-21
UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5; S... 103 3e-21
UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5; F... 103 4e-21
UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 103 4e-21
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 103 5e-21
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 102 8e-21
UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1; C... 100 3e-20
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 99 5e-20
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 99 5e-20
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 99 5e-20
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 99 5e-20
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 99 8e-20
UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1; P... 99 8e-20
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 97 4e-19
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 97 4e-19
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 95 1e-18
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 95 2e-18
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 94 3e-18
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 93 4e-18
UniRef50_Q5A0M0 Cluster: Putative uncharacterized protein; n=2; ... 93 7e-18
UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 91 3e-17
UniRef50_Q0A635 Cluster: Isocitrate/isopropylmalate dehydrogenas... 89 8e-17
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 89 8e-17
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 89 1e-16
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 87 4e-16
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 85 1e-15
UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenas... 85 2e-15
UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30; ... 84 2e-15
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 81 2e-14
UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1; ... 76 8e-13
UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3; D... 76 8e-13
UniRef50_Q7X199 Cluster: Lfe195p1; n=2; Leptospirillum|Rep: Lfe1... 73 6e-12
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 72 1e-11
UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_030007... 69 1e-10
UniRef50_A0FP11 Cluster: Isocitrate/isopropylmalate dehydrogenas... 59 8e-08
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 57 4e-07
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 53 7e-06
UniRef50_Q8KH40 Cluster: LeuB; n=2; Buchnera aphidicola|Rep: Leu... 50 4e-05
UniRef50_Q6L1Z1 Cluster: Isocitrate dehydrogenase [NADP]; n=1; P... 48 3e-04
UniRef50_Q11SB4 Cluster: Putative uncharacterized protein ttuC; ... 45 0.002
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 43 0.005
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 43 0.007
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 37 0.48
UniRef50_A2R1W4 Cluster: Differential expressed Arsa-7 from pate... 37 0.48
UniRef50_Q2NTK1 Cluster: Putative uncharacterized protein; n=1; ... 36 0.63
UniRef50_Q4IUS8 Cluster: Putative uncharacterized protein; n=1; ... 36 0.63
UniRef50_A1D5P0 Cluster: Isocitrate dehydrogenase family protein... 35 1.5
UniRef50_P12349 Cluster: Period circadian protein; n=45; Schizop... 35 1.5
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 35 1.9
UniRef50_Q13GJ7 Cluster: Transferase, hexapeptide repeat protein... 34 2.5
UniRef50_A1FSL4 Cluster: CarR; n=1; Stenotrophomonas maltophilia... 34 2.5
UniRef50_O42913 Cluster: Negative regulator of MBF; n=1; Schizos... 34 2.5
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 34 3.4
UniRef50_Q4SME7 Cluster: Chromosome 8 SCAF14552, whole genome sh... 33 4.4
UniRef50_Q7NIG2 Cluster: Gll2221 protein; n=1; Gloeobacter viola... 33 4.4
UniRef50_Q1Q0V0 Cluster: Similar to pyridoxal phosphate biosynth... 33 4.4
UniRef50_Q5LD27 Cluster: Putative uncharacterized protein; n=1; ... 33 5.9
UniRef50_Q2CHG7 Cluster: Parallel beta-helix repeat protein; n=4... 33 5.9
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 33 5.9
UniRef50_UPI0000F1E8DC Cluster: PREDICTED: similar to B-cell lin... 33 7.7
UniRef50_A1B0Y4 Cluster: Putative uncharacterized protein; n=1; ... 33 7.7
UniRef50_Q7PDQ3 Cluster: ERYTHROCYTE MEMBRANE PROTEIN PFEMP3; n=... 33 7.7
UniRef50_Q6C8U9 Cluster: Yarrowia lipolytica chromosome D of str... 33 7.7
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 265 bits (650), Expect = 5e-70
Identities = 121/166 (72%), Positives = 144/166 (86%), Gaps = 1/166 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIMRMSDGLFL+ CR++A DIKF E YLDTVCLNMVQDPS+FDVLVMPNLYG
Sbjct: 197 AVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYG 256
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD+C+GL+GGLG+TPSGNIG NG A+FESVHGTAPDIAGKDMANPTALLLSA+MMLR
Sbjct: 257 DILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLR 316
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
H+ L +HA R++ AC+ +++GKSLT DLGG KCS++T I ++
Sbjct: 317 HMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 256 bits (628), Expect = 3e-67
Identities = 114/165 (69%), Positives = 141/165 (85%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIMR SDGLFL CR+ A Y DIKF+E YLDTVCLNMVQDPS++DVLVMPNLYG
Sbjct: 190 AVHKANIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQDPSQYDVLVMPNLYG 249
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD+C+GLVGGLG+TPSGNIGK A+FESVHGTAPDIAG+D ANPTALLLSA+MMLR+
Sbjct: 250 DILSDLCAGLVGGLGVTPSGNIGKGAAVFESVHGTAPDIAGQDKANPTALLLSAVMMLRY 309
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ L +HA R++ A ++ + +G++ TGDLGGTG CS +T + +++
Sbjct: 310 MNLPQHAARIEKAVFDAIADGRAKTGDLGGTGTCSSFTADVCARV 354
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 214 bits (523), Expect = 1e-54
Identities = 97/166 (58%), Positives = 133/166 (80%), Gaps = 1/166 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
A+HKANIM+ +DGLFL+CC ++A KY +I +E+ +D C+ +V++P+ FDVLVMPNLYG
Sbjct: 209 AIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYG 268
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD+C+GLVGGLGLTPS NIG++G AL E+VHG+APDIAG ++ANPTALLLS +MMLR
Sbjct: 269 DIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLR 328
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
HL+LN+ A+++ +A + EGK T DLGG+ +++T AI L
Sbjct: 329 HLKLNKQAEQIHSAIINTIAEGKYRTADLGGSSTTTDFTKAICDHL 374
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 204 bits (498), Expect = 1e-51
Identities = 86/166 (51%), Positives = 129/166 (77%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
++HKANIM+MSDGLF+RC R+++ +Y +I + E +D C+ +V +P ++D+L++ NLYG
Sbjct: 168 SIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLENLYG 227
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD+C+GLVGGLGL P NIG+ ++FE+VHG+APDIAGK++ANPTA++ S I+MLRH
Sbjct: 228 DIVSDLCAGLVGGLGLAPGANIGERASIFEAVHGSAPDIAGKNIANPTAVIRSGILMLRH 287
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
L + A+RV+ A + V REGK LT D+GGT SE+ + ++ ++
Sbjct: 288 LDEQDAANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVEAIH 333
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 181 bits (441), Expect = 1e-44
Identities = 83/166 (50%), Positives = 118/166 (71%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
A+HKAN+M+ + GLF CR++A Y +I++ + Y+D C+ +V DP +FDV+V N++G
Sbjct: 162 ALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFG 221
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD+ +GLVGGLGL PS N+G+ A+FE VHG A DIAGK +ANPTA++L+A MMLRH
Sbjct: 222 DIVSDLAAGLVGGLGLAPSANVGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRH 281
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
E A +V+ A + ++EGK T DLGG K E+ N + S L+
Sbjct: 282 FGYVEEAKKVEEAVEKTIKEGKK-TPDLGGNLKTMEFANEVASLLD 326
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 180 bits (438), Expect = 3e-44
Identities = 80/152 (52%), Positives = 113/152 (74%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANI++ +DGLFL R +A++Y D++FE+R +D +C+ +VQ P +DVLV+PNLYG
Sbjct: 189 AVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDVLVLPNLYG 248
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD+ +GLVGGLG+ P NIG A+FE++HG+AP AG++ NP+AL+LS ++LRH
Sbjct: 249 DIVSDLTAGLVGGLGVAPGANIGDRSAVFEAIHGSAPRYAGQNKVNPSALILSGALLLRH 308
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTG 458
L E A RV+ A V+ EG+S+T DL G
Sbjct: 309 LGEQEAAVRVEQAVAAVIAEGRSVTYDLAPAG 340
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 176 bits (429), Expect = 3e-43
Identities = 86/168 (51%), Positives = 117/168 (69%), Gaps = 4/168 (2%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFD--VLVMPNLY 179
VHK+ I R++DGLF+ ++L+ +Y D+ E +D L +V +PS + V V PNLY
Sbjct: 202 VHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLY 261
Query: 180 GDIMSDMCSGL-VGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
GDI+SD+ SGL G LGLTPS NIG ++FE+VHG+APDIAG+D ANPTALLLS++MML
Sbjct: 262 GDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMML 321
Query: 357 RHLQLNEHADRVQNACYEVLREG-KSLTGDLGGTGKCSEYTNAIISKL 497
H+ L HAD++QNA + G ++ TGDL GT S +T A+I +L
Sbjct: 322 NHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 369
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 175 bits (425), Expect = 1e-42
Identities = 79/148 (53%), Positives = 111/148 (75%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIM+ +DGLFL+ R++A +Y DI+FE+ +D +CL ++Q P +DVLV+ NLYG
Sbjct: 188 AVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCLQLMQKPQLYDVLVLTNLYG 247
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD+C+G++GGLG+ P NIG A+FE++HG+AP AG++ NP+AL+LS MMLR+
Sbjct: 248 DIISDLCAGMIGGLGVAPGANIGDGIAVFEAIHGSAPKYAGQNKVNPSALILSGAMMLRY 307
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDL 446
L E A RV+ A V+ EGK +T DL
Sbjct: 308 LGEREAAARVEAAVQSVIAEGKYVTYDL 335
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 168 bits (408), Expect = 1e-40
Identities = 82/172 (47%), Positives = 114/172 (66%), Gaps = 6/172 (3%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIM+++DGLFL CR++A KY I + E +D C+ +V P +FDV+V PNLYG
Sbjct: 198 AVHKANIMKLADGLFLESCREVAKKYPSITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 257
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKD------MANPTALLLSA 344
+++++ +G+ GG G+ P GN+G + A+FE G + GKD ANP ALLLS+
Sbjct: 258 NLVANTAAGIAGGTGVMPGGNVGADHAVFE--QGASAGNVGKDKIVLENKANPVALLLSS 315
Query: 345 IMMLRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
MMLRHLQ ADR++ A +V+ EGK T DLGGT E +A+I+KL+
Sbjct: 316 AMMLRHLQFPSFADRLETAVKKVIAEGKCRTKDLGGTSTTQEVVDAVIAKLD 367
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 166 bits (403), Expect = 5e-40
Identities = 79/165 (47%), Positives = 113/165 (68%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSD-IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
VHKAN+++ GLFL + + Y+D I+F +R +D + +V +P +FDV+V NL+G
Sbjct: 180 VHKANVLKALTGLFLETAKQVGLNYADQIEFNDRIVDACAMQLVLNPWQFDVIVSTNLFG 239
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD +GLVGGLG+ P NIG+ A+FE+VHG+APDIAGK MANPTALLL+A +ML H
Sbjct: 240 DILSDQIAGLVGGLGMAPGANIGERAAIFEAVHGSAPDIAGKGMANPTALLLAAALMLEH 299
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L+ A +++A VL E T DLGG+ S+Y + +I ++
Sbjct: 300 KGLHGQAKFLRDAIDAVLGEESGRTADLGGSTSTSKYGDLLIERI 344
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 164 bits (398), Expect = 2e-39
Identities = 81/168 (48%), Positives = 113/168 (67%), Gaps = 3/168 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDL-ATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLY 179
AVHKANIM++ DGLF ++ A +Y ++ + +D + V P +FDVLV PNLY
Sbjct: 192 AVHKANIMKLGDGLFRNTVNEIGANEYPELDVKNIIVDNASMQAVAKPHQFDVLVTPNLY 251
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNGALFE--SVHGTAPDIAGKDMANPTALLLSAIMM 353
G I+ ++ S L+GG GL P N G+ A+FE S H DI G+++ANPTA++LS+ +M
Sbjct: 252 GSILGNIGSALIGGPGLVPGANFGREYAVFEPGSRH-VGLDIKGQNVANPTAMILSSTLM 310
Query: 354 LRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
LRHL LN +ADR+ A Y+V+ EGKS T D+GG+ SE+TNA+I KL
Sbjct: 311 LRHLGLNAYADRISKATYDVISEGKSTTRDIGGSASTSEFTNAVIEKL 358
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 162 bits (393), Expect = 7e-39
Identities = 80/163 (49%), Positives = 110/163 (67%)
Frame = +3
Query: 9 HKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDI 188
HKAN+++++DGLF + +A +Y DIK E+ Y+D + + ++ P FDV+V NL+GDI
Sbjct: 169 HKANVLKLTDGLFKKIFYKVAEEYDDIKAEDYYIDAMNMYIITKPQVFDVVVTSNLFGDI 228
Query: 189 MSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQ 368
+SD +G VGGLGL PS NIG LFE VHG+APDIAGK +ANPTA +LSA++MLR+L
Sbjct: 229 LSDGAAGTVGGLGLAPSANIGDEHGLFEPVHGSAPDIAGKKIANPTATILSAVLMLRYLG 288
Query: 369 LNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
E AD+V+ A EVL G + T DLGG E + ++
Sbjct: 289 EYEAADKVEKALEEVLALGLT-TPDLGGNLNTFEMAEEVAKRV 330
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 161 bits (391), Expect = 1e-38
Identities = 74/167 (44%), Positives = 117/167 (70%), Gaps = 1/167 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIM+M DGLFLRCC +++ Y +I+F +D C+ +V P +FDV+V+PNLYG
Sbjct: 220 AVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLPNLYG 279
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFES-VHGTAPDIAGKDMANPTALLLSAIMMLR 359
+I+S++ + LVGG G+ P NIG + A+FES T DI GKD++NP ++L ++ +ML
Sbjct: 280 NIVSNIGASLVGGPGIVPGENIGGDYAIFESGSRHTGLDIQGKDISNPISMLFASTLMLE 339
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
HL+ +AD + +A +V++ G LT D+GG+ +++ +A+ S+L+
Sbjct: 340 HLEFTAYADLINSAILKVVQRG-VLTADVGGSHTTTQFLSALKSELD 385
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 161 bits (391), Expect = 1e-38
Identities = 75/166 (45%), Positives = 110/166 (66%), Gaps = 1/166 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIM++ DGLFL+CC ++A Y IKFE +D C+ +VQ+P +FDVLVMPNLYG
Sbjct: 215 AVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFES-VHGTAPDIAGKDMANPTALLLSAIMMLR 359
+I+ ++ +GLVGG G+ P + A+FE+ G+++ANPTA+LLSA MLR
Sbjct: 275 NIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR 334
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
HL L H+ + +A +V++ GK T D+GG +++ ++I L
Sbjct: 335 HLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 158 bits (383), Expect = 1e-37
Identities = 78/171 (45%), Positives = 110/171 (64%), Gaps = 6/171 (3%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIM+++DGLFL CR++A YS I + E +D C+ +V P +FDV+V PNLYG
Sbjct: 199 AVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 258
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKD------MANPTALLLSA 344
+++++ +G+ GG G+ P GN+G A+FE G + G D ANP ALLLS+
Sbjct: 259 NLIANTAAGIAGGTGVMPGGNVGAEHAIFE--QGASAGNVGNDKMVEQKKANPVALLLSS 316
Query: 345 IMMLRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
MMLRHL+ ADR++ A +V++EGK T DLGG E +A+I+ L
Sbjct: 317 AMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAAL 367
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 157 bits (381), Expect = 2e-37
Identities = 78/165 (47%), Positives = 110/165 (66%), Gaps = 3/165 (1%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K+NIM++++G R +A +Y DI+ +D +V+ P +F+V+V N+ GDI+
Sbjct: 191 KSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDIL 250
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQL 371
SD+ SGL+GGLG PS NIG A+FE+VHG+AP AGK++ NPTA+LLSA+MMLR+L+
Sbjct: 251 SDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEE 310
Query: 372 NEHADRVQNACYEVLREGKSLTGDLGG---TGKCSEYTNAIISKL 497
AD ++NA L EG+ LTGD+ G K +EYT AII L
Sbjct: 311 FATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNL 355
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 157 bits (380), Expect = 3e-37
Identities = 74/164 (45%), Positives = 109/164 (66%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHK+N++ ++ GLF+ D + +D + +V++P +FDV+VM N++GD
Sbjct: 170 VHKSNVLPVTQGLFMNTILDHTKTVEGLSTSTMIVDNAAMQLVRNPQQFDVMVMTNMFGD 229
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD+ +GLVGGLG+ SGN+G +FESVHG+APDIAG+ ++NPTA +L+A++ML HL
Sbjct: 230 ILSDLAAGLVGGLGIAASGNVGDQFGIFESVHGSAPDIAGQGISNPTATILAAVIMLDHL 289
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+E A R+ NA +VL E T DLGGT E+T A+I L
Sbjct: 290 GDHETARRLDNAINKVLAEXPR-TRDLGGTAGTQEFTEAVIKAL 332
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 157 bits (380), Expect = 3e-37
Identities = 75/163 (46%), Positives = 106/163 (65%), Gaps = 1/163 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKANIM++ DGLFL+CCR++A +Y I FE +D + +V P +FDV+VMPNLYG
Sbjct: 218 AVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYG 277
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFE-SVHGTAPDIAGKDMANPTALLLSAIMMLR 359
+I++++C+GLVGG GL N G A+FE + T IA K++ANPTA LL++ MML
Sbjct: 278 NIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLD 337
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAII 488
HL+L+ +A ++ A + T D+GG G SE +I
Sbjct: 338 HLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVI 380
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 153 bits (370), Expect = 5e-36
Identities = 78/171 (45%), Positives = 105/171 (61%), Gaps = 7/171 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHKAN+MR++DGLF CR + +++ E Y+D N+V++P FDV+V N+YGD
Sbjct: 168 VHKANVMRITDGLFAEACRSVLK--GKVEYSEMYVDAAAANLVRNPQMFDVIVTENVYGD 225
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD S + G LG+ PS NIG ALFE VHG A DIAGK++ NPTA LLS MM +
Sbjct: 226 ILSDEASQIAGSLGIAPSANIGDKKALFEPVHGAAFDIAGKNIGNPTAFLLSVSMMYERM 285
Query: 366 QLNEHADR-------VQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ DR ++NA Y V +E K+LT D+GG + N I +KL
Sbjct: 286 YELSNDDRYIKASRALENAIYLVYKERKALTPDVGGNATTDDLINEIYNKL 336
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 152 bits (369), Expect = 6e-36
Identities = 68/150 (45%), Positives = 104/150 (69%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
AVHKAN+++ +DG+F +A++Y ++ + Y+D + ++ P +F +V NL+G
Sbjct: 164 AVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIVTTNLFG 223
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD +GL+GGLGL PS NIG+ ALFE VHG+AP IAGK++ANPTA++L+ +ML+H
Sbjct: 224 DILSDEAAGLIGGLGLAPSANIGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKH 283
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGG 452
L + A +++ A + L EG +T DLGG
Sbjct: 284 LNKKQEAQKIEKALQKTLAEG-LVTPDLGG 312
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 152 bits (368), Expect = 8e-36
Identities = 74/171 (43%), Positives = 112/171 (65%), Gaps = 7/171 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHK+N+MR++DG+F + C +++ Y DI FE+ Y+D +N+++ P +FDV+V NL+GD
Sbjct: 168 VHKSNVMRVTDGMFAKACTEVSKDYPDISFEQMYVDACAMNLIRQPQEFDVVVTTNLFGD 227
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD S +VGGLG+ P+ NIG N ALFE VHG A DIAG+++ANP++ LLS MML L
Sbjct: 228 ILSDESSQVVGGLGMAPAANIGDNFALFEPVHGAAFDIAGQNIANPSSFLLSIKMMLDWL 287
Query: 366 -------QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ E ++++ + +++ G T D+GG SE+T I L
Sbjct: 288 GTKNSDSKCFEVGQKLESTIFNLVKTGVK-TKDIGGDKTTSEFTKQITDNL 337
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 151 bits (367), Expect = 1e-35
Identities = 70/160 (43%), Positives = 101/160 (63%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+HKAN++ +DGLFLR +++A Y DI ++ +D C ++V+DP FDV+V N YGD
Sbjct: 181 LHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPCWFDVVVTVNQYGD 240
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I SD+ +GL G LGL P NIG + + FE+ HG APDIAG ANP AL+LS +L H
Sbjct: 241 IFSDLAAGLAGSLGLAPGANIGDSASTFEAAHGAAPDIAGTGAANPIALILSGAELLAHA 300
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAI 485
+ ++ ++ A V+ G++LT DLGG + +AI
Sbjct: 301 GYGKGSEAIREAVTRVIEAGRTLTPDLGGRSTTEQVADAI 340
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 149 bits (360), Expect = 7e-35
Identities = 71/165 (43%), Positives = 111/165 (67%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN++ + L+ R +++A++Y +I+ + Y+D + + M++ P F+V+V PN++GD
Sbjct: 182 VDKANVLTYAHDLWQRVFKEVASEYQEIETDHYYVDAMAMKMIRSPEIFEVVVTPNMFGD 241
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
I++D+ + +VGGLGL SGNI G ++FE VHG+APDIAGK +ANP A +L+A +ML H
Sbjct: 242 ILTDLGAEIVGGLGLAASGNINPRGVSMFEPVHGSAPDIAGKGIANPLAAILTAALMLEH 301
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L L+ A V+ A + + E K +T DLGG K SE N ++ L
Sbjct: 302 LGLDREASLVEKAVAKTIEENK-VTPDLGGELKTSEVGNEVVKNL 345
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 148 bits (358), Expect = 1e-34
Identities = 74/169 (43%), Positives = 109/169 (64%), Gaps = 3/169 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATK-YSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLY 179
AVHKANIM++ DGLF ++ K Y DI +D + V P +FDVLV P++Y
Sbjct: 191 AVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMY 250
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNGALFE--SVHGTAPDIAGKDMANPTALLLSAIMM 353
G I+ ++ + L+GG GL N G++ A+FE S H DI G+++ANPTA++LS+ +M
Sbjct: 251 GTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRH-VGLDIKGQNVANPTAMILSSTLM 309
Query: 354 LRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
L HL LNE+A R+ A +E + EGK T D+GG+ +++TN II+KL+
Sbjct: 310 LNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 146 bits (355), Expect = 3e-34
Identities = 68/167 (40%), Positives = 103/167 (61%), Gaps = 1/167 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+VHKANIM++ DGLFL+ C D+A Y I+F++ +D + +V P +FDVLV PNLYG
Sbjct: 206 SVHKANIMKLGDGLFLKSCEDMAKLYPRIEFQKMIVDNTTMQIVSHPHQFDVLVTPNLYG 265
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFE-SVHGTAPDIAGKDMANPTALLLSAIMMLR 359
I+ ++ +G+VGG GL + + +FE T + GK++ANPTA+ +LR
Sbjct: 266 SIIDNLFAGIVGGAGLVAGASYSPDTVVFEPGARHTFSEAVGKNVANPTAMFFCGTKLLR 325
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
H+ L +++ + NA VL EGK T DLGG E+T A+I+ ++
Sbjct: 326 HINLPTYSEMLTNAIIRVLSEGKVRTKDLGGNATTQEFTRAVIANIH 372
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 146 bits (354), Expect = 4e-34
Identities = 71/162 (43%), Positives = 107/162 (66%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+HKAN++R++DGLFL ++ Y+ I+ ++ +D+ +N+++ P KFDV+V N++GD
Sbjct: 179 IHKANVLRITDGLFLEVFNEIKKHYN-IEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGD 237
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD S L+GGLGL PS NIG + ALFE VHG+APDIAGK +ANP A +LS M+ ++
Sbjct: 238 ILSDEASALIGGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYI 297
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIIS 491
E D ++ A L K +T DLGG K + + I++
Sbjct: 298 GEKEKGDLIREAVKYCL-INKKVTPDLGGDLKTKDVGDEILN 338
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 146 bits (353), Expect = 5e-34
Identities = 65/138 (47%), Positives = 100/138 (72%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K NIM+ +DG+F + ++A++YS+I+ + +D ++ P KFDV+V NLYGDI+
Sbjct: 175 KDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDIL 234
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQL 371
SD+ + + G +GL S NIGK+ A+FE+VHG+APDIAG+++ANP+ LL +AIMML HL L
Sbjct: 235 SDIAAKISGSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGL 294
Query: 372 NEHADRVQNACYEVLREG 425
EHA +++NA + + +G
Sbjct: 295 TEHAAKIENALKKTIEDG 312
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 144 bits (350), Expect = 1e-33
Identities = 71/167 (42%), Positives = 101/167 (60%), Gaps = 4/167 (2%)
Frame = +3
Query: 9 HKANIMRMSDGLFLRCCRDL----ATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNL 176
HK+N++ SDGLF C+++ KY IK+ E+ +D++ + ++P FDV+V PNL
Sbjct: 205 HKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNL 264
Query: 177 YGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
YGDI+SD + LVG LG+ PS N+G + E HG+APDIAGK +ANP A + S +ML
Sbjct: 265 YGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALML 324
Query: 357 RHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L NE A + A LREG T DLGG + + ++S+L
Sbjct: 325 EFLGHNEAAQDIYKAVDANLREGSIKTPDLGGKASTQQVVDDVLSRL 371
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 140 bits (339), Expect = 3e-32
Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%)
Frame = +3
Query: 9 HKANIMRMSDGLFLRCCRDLATKY-SDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
HKANIMRM+DG FL R A K+ D+ FEERYLDT L ++ P K DV+V ++YGD
Sbjct: 228 HKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGD 287
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
++ + G++G G+ P ++ G +F+ +AGKD+ANPT LLSA +MLRH+
Sbjct: 288 VLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHV 347
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAI 485
++++ AD+V A +V ++ T D+GG KCSE+ A+
Sbjct: 348 KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAV 387
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 140 bits (338), Expect = 3e-32
Identities = 74/171 (43%), Positives = 108/171 (63%), Gaps = 7/171 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHKAN+MR++ GLF +++ + ++ +E Y+D + +V+ P +FDV++ PN++GD
Sbjct: 172 VHKANVMRVTCGLFRDVAKEVL-EAEGVEVDEMYVDAAAMELVRRPERFDVMLTPNVFGD 230
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD+ + +VG LGL PSGNIG+ ALFE VHG A DIAGK +ANPTA +L+A MML L
Sbjct: 231 ILSDLAAQVVGSLGLAPSGNIGEERALFEPVHGAAFDIAGKGIANPTATMLAASMMLEWL 290
Query: 366 QLN-------EHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ E A +Q A + L EG T DLGG E+ ++ +L
Sbjct: 291 ERKKGLPKGAEAAAALQRAIEKALSEGVK-TPDLGGNYGTFEFAEEVVKRL 340
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 139 bits (337), Expect = 5e-32
Identities = 75/164 (45%), Positives = 103/164 (62%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHK+N+++ +D LF C +A K ++ FE+ +DT N+V+ P KFD +V N++GD
Sbjct: 160 VHKSNVLK-ADELFKDACAQVA-KSMNVPFEDMLVDTTAYNLVRAPEKFDTIVTTNMFGD 217
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD + L+G LGL+PS N+G ALFE VHG+APDIAGK +ANP A +LSA M+L
Sbjct: 218 ILSDEAAALIGSLGLSPSANVGDRYALFEPVHGSAPDIAGKGIANPFAAVLSAGMLLDWA 277
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
E A VQ A + EG LT DLGG + +AI+ L
Sbjct: 278 GRPEMARAVQTAVDRTIDEG-VLTPDLGGRNTTLQVQSAILKNL 320
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 137 bits (332), Expect = 2e-31
Identities = 74/174 (42%), Positives = 102/174 (58%), Gaps = 10/174 (5%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHKAN++R + GLF ++A Y D++ +E +DT L + P +FDV+V NL+GD
Sbjct: 187 VHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPERFDVIVTTNLFGD 246
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD+ GGLGL PS N+G+ ALFE VHG APDIAGK +ANP A + ++L HL
Sbjct: 247 ILSDVACAWGGGLGLAPSANLGERHALFEPVHGAAPDIAGKGIANPLAAIGCTALLLDHL 306
Query: 366 QLNEHAD----------RVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
AD R+Q A V G T DLGG+ ++ TNA++S +
Sbjct: 307 AGRAPADLASAMRGWSARIQRAIRHVRAAGPH-TPDLGGSAVTTDITNAVLSHM 359
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 134 bits (325), Expect = 1e-30
Identities = 68/165 (41%), Positives = 99/165 (60%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+HKANIM+++DGLFL R++A Y DI+ + +D C+ +V +P +FDV+ NLYG
Sbjct: 214 IHKANIMKLADGLFLSVAREVAKDYPDIQHNDMIIDNCCMQLVSNPHQFDVMNTTNLYGS 273
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFE-SVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
I S++ GLVGG GL N G + A+FE T IAGK++ANP A+L +A+ ML H
Sbjct: 274 ITSNVLCGLVGGAGLFSGRNYGDHFAVFEPGTRNTGTAIAGKNIANPIAMLNAAVDMLYH 333
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L N HAD + +A ++ + T DLGG +E ++ L
Sbjct: 334 LGHNYHADCISDAIHKTIDVDGVHTPDLGGQNTSTEVVQNVLQHL 378
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 134 bits (323), Expect = 2e-30
Identities = 60/120 (50%), Positives = 84/120 (70%)
Frame = +3
Query: 87 IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGAL 266
I++ ER +D +C+ +VQ P +DVLV NLYGDI+SD+C+GLVGGLG+ P NIG A+
Sbjct: 247 IEYNERLIDNMCMQLVQKPELYDVLVTSNLYGDILSDLCAGLVGGLGVAPGSNIGTEAAI 306
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDL 446
FE+ HG+AP G++ NP AL+LS MML +L +E A ++ A +V+ EGK +T DL
Sbjct: 307 FEATHGSAPKYKGQNKVNPVALILSGKMMLDYLGEHEAAAKLDKAVADVIEEGKDVTYDL 366
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 133 bits (321), Expect = 4e-30
Identities = 65/166 (39%), Positives = 98/166 (59%), Gaps = 1/166 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+HKANIM++SDGLFL + Y +++ +D C+ V +P +FDV+ M NLYG
Sbjct: 222 IHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGT 281
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFE-SVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
I+S++ GL+GG GL N G + A+FE T IAGK++ANP A++ ++I ML H
Sbjct: 282 IVSNVLCGLMGGAGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAMISASIDMLNH 341
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
L EHA+ +Q A Y+ + T D+GGT ++ I+ L+
Sbjct: 342 LGHKEHANVIQEAVYQTIVNDAIRTPDIGGTNSSTDVVENILKILS 387
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 132 bits (320), Expect = 5e-30
Identities = 62/149 (41%), Positives = 94/149 (63%), Gaps = 1/149 (0%)
Frame = +3
Query: 54 CCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLT 233
CC ++A Y IKFE +D C+ +VQ+P +FDVLVMPNLYG+I+ ++ +GLVGG G+
Sbjct: 178 CCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVV 237
Query: 234 PSGNIGKNGALFES-VHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYE 410
P + A+FE+ G+++ANPTA+LLSA MLRHL L H+ + +A +
Sbjct: 238 PGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKK 297
Query: 411 VLREGKSLTGDLGGTGKCSEYTNAIISKL 497
V++ GK T D+GG +++ ++I L
Sbjct: 298 VIKVGKVRTRDMGGYSTTTDFIKSVIGHL 326
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 132 bits (320), Expect = 5e-30
Identities = 69/168 (41%), Positives = 103/168 (61%), Gaps = 3/168 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+ KAN++ S F ++A ++ DIK E Y+D L +V+ P FDV+V N++GD
Sbjct: 188 IDKANVLS-SMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFDVMVTENMFGD 246
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR-- 359
I+SD+ +GLVGG+G+ PSG+IG + A+F+ HG+APDIAG+ +ANP A+ LS MML
Sbjct: 247 ILSDLAAGLVGGMGMAPSGDIGDDAAVFQPSHGSAPDIAGQSIANPIAMHLSTAMMLEWL 306
Query: 360 -HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN 500
H + AD + A +VL + T D+GG E T+ I +L+
Sbjct: 307 DHPETRRAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAERLS 354
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 129 bits (312), Expect = 5e-29
Identities = 62/138 (44%), Positives = 91/138 (65%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K NIM+ SDG+F + ++A +Y I E +D + P FDV+V NLYGDI+
Sbjct: 175 KDNIMKFSDGVFHKIFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDII 234
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQL 371
SD+ + + G +GL S NIG++ A+FE+VHG+APDIAGKD+ANP+ LL +AIMML H+
Sbjct: 235 SDVAAEISGSVGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQ 294
Query: 372 NEHADRVQNACYEVLREG 425
+ A ++NA + + +G
Sbjct: 295 GDIASLIENAWKKTIEDG 312
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 129 bits (311), Expect = 6e-29
Identities = 67/165 (40%), Positives = 102/165 (61%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATK-YSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
VHKAN++R+ DG F RD+A + ++ ++ Y+D + +V++P +FDV++ N YG
Sbjct: 131 VHKANVLRVVDGFF----RDIALEELKGLEVDQMYVDAAAMELVRNPKRFDVVLTMNQYG 186
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI++D+ + + GG+GL PSGNIG A+FE VHG A DIAGK +ANP A +LSA MM
Sbjct: 187 DILTDLAAQVAGGIGLAPSGNIGDAKAMFEPVHGAAFDIAGKGVANPIATILSAAMMFEW 246
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ + A++++ A + + G T D+GG E I S L
Sbjct: 247 MGRGDVAEKIRGAVEKSIEAGVK-TPDIGGDKSTIEVGKFIASIL 290
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 128 bits (310), Expect = 9e-29
Identities = 66/171 (38%), Positives = 103/171 (60%), Gaps = 8/171 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATK-YSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
VHKAN++ M+ GLF CR++ + Y D++ ++ ++D + ++V+ FDV+V N++G
Sbjct: 192 VHKANVLSMTTGLFRDVCREVGQRDYPDVRIDDEHVDAMTAHLVRRGRDFDVVVTENMFG 251
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI+SD+ L G LG PS N + + ++ HG APDIAG + ANPTAL+LSA MML
Sbjct: 252 DILSDLTGELSGSLGTAPSINSSETKVMAQAAHGAAPDIAGHNRANPTALMLSAAMMLEW 311
Query: 363 L-------QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISK 494
L L A R+++A + G + T DLGG SE+T ++++
Sbjct: 312 LGDRRADRNLGGAAHRIRDAVRATIASGVA-TADLGGLASTSEFTETVLAR 361
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 128 bits (310), Expect = 9e-29
Identities = 61/135 (45%), Positives = 90/135 (66%), Gaps = 3/135 (2%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHK N++ GL+ R ++A +Y ++ + ++D + +V DPS+FDV+V NL+GD
Sbjct: 177 VHKTNVLVHGGGLWQRTVDEVAREYPEVTVDYNHIDAATIYLVTDPSRFDVIVTDNLFGD 236
Query: 186 IMSDMCSGLVGGLGLTPSGNI---GKNGALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
I++D + GG+GL SGNI G N ++FE VHG+APDI GK +A+PTA +LSA MML
Sbjct: 237 ILTDEAGAISGGIGLAASGNIDATGTNPSMFEPVHGSAPDIMGKGIADPTAAILSAAMML 296
Query: 357 RHLQLNEHADRVQNA 401
RHL +A R++ A
Sbjct: 297 RHLGDEANAVRIEEA 311
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 128 bits (309), Expect = 1e-28
Identities = 64/165 (38%), Positives = 105/165 (63%), Gaps = 1/165 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN++ + L+ R +++ +Y D++ + Y+D + + M++ P FDV+V PN++GD
Sbjct: 183 VDKANVLTYAHDLWERVFAEVSQEY-DLETDHYYVDAMAMKMIRSPESFDVVVTPNMFGD 241
Query: 186 IMSDMCSGLVGGLGLTPSGNIG-KNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
I++D+ + +VGGLG+ SGNI + +FE VHG+APDIAGK +ANP A +LSA MML +
Sbjct: 242 ILTDLGAEIVGGLGIAASGNINPETTGMFEPVHGSAPDIAGKRIANPLAAILSASMMLEY 301
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L L + + ++ A + E K +T D+ G K E + ++ L
Sbjct: 302 LNLEKESKWIEEAVKRAIAENK-VTPDMNGNLKTYEVGDWVVKFL 345
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 128 bits (308), Expect = 1e-28
Identities = 62/159 (38%), Positives = 98/159 (61%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K N++R S + A +Y I+ + +D V L +++ P KF V+V N++GDI+
Sbjct: 206 KPNVLRESGEFTRKIFESTAQRYPKIQADILNVDAVALWLIKSPEKFGVIVAENMFGDIL 265
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQL 371
SD+ +G++GGLGL PS NIG G+ FE VHG+ P I K+ ANP+A+ L+ M+L H
Sbjct: 266 SDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGY 324
Query: 372 NEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAII 488
+ A ++ NA +V++E + +T DLGG ++ NA+I
Sbjct: 325 PDRAKKIVNAVMQVIKEKRFITYDLGGHATTTDMANAVI 363
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 126 bits (305), Expect = 3e-28
Identities = 68/166 (40%), Positives = 94/166 (56%), Gaps = 2/166 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN +R L+ RC + ++ I Y+DT L + DP+ FDV+V N YGD
Sbjct: 195 VDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNSYGD 254
Query: 186 IMSDMCSGLVGGLGLTPSGNIG--KNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
I+SD+ + L GGLG+ S N+ ALFE VHG+APDIAG ANP +LS ++
Sbjct: 255 ILSDLTAALAGGLGVAASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAILSVALLAE 314
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
HL NE AD V+ A + G+ +T DLGG E A++++L
Sbjct: 315 HLGRNEEADAVRRAVAAAVAAGR-VTPDLGGPLGTKEVGAAVLAEL 359
>UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 351
Score = 126 bits (304), Expect = 5e-28
Identities = 65/167 (38%), Positives = 108/167 (64%), Gaps = 2/167 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATK-YSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLY 179
+V KAN++ +S+ L+ R + L + Y ++ Y+D+V + +V +PS++DV++ NL+
Sbjct: 182 SVDKANVLEVSE-LWRRDVQALRDREYRNVHLNHEYVDSVAMLIVANPSRYDVILTENLF 240
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
GDI+SD+ + + G LGL PS ++G LFE +HG+APDIAG+ +ANP A ++S M+LR
Sbjct: 241 GDILSDLAAVIPGSLGLMPSASLGDGPGLFEPIHGSAPDIAGQGIANPAAAIMSVAMLLR 300
Query: 360 H-LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
H L+ + A++V+ A LRE T DLGG +T+A++ +
Sbjct: 301 HGLERPQVANQVERAVALALREHP--TRDLGGQADTRTFTHAVLDAM 345
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 124 bits (300), Expect = 1e-27
Identities = 62/167 (37%), Positives = 103/167 (61%), Gaps = 2/167 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
++ KAN++ S L+ ++A +Y D++ E +D + ++++P +FDV+V NL+G
Sbjct: 180 SIDKANVLESSK-LWRIVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFG 238
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMML- 356
DI+SD S L G LG+ PS + + G +L+E +HG+APDIAGK+ ANP A++ S MML
Sbjct: 239 DILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLG 298
Query: 357 RHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ L ++ A VL+ GK T D+GGT + +T A++ ++
Sbjct: 299 QSFGLTREGCAIEEAISAVLKSGK-CTADIGGTETTTSFTKAVMQEM 344
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 124 bits (298), Expect = 2e-27
Identities = 61/156 (39%), Positives = 105/156 (67%), Gaps = 7/156 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHKAN++++ DG+FL CR A Y+ ++ ++ +D + ++V++P +FDV+V N++GD
Sbjct: 193 VHKANVLKIGDGMFLDICRAAAKGYAGLEVDDILVDAMMAHVVRNPDRFDVIVATNMFGD 252
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLS-AIMMLRH 362
I+SD+ + L G LGL S N+G A+ ++ HG+APDIAG+D+ANP +L+LS A+++ H
Sbjct: 253 ILSDLTAELSGSLGLGGSLNVGDRYAMAQAAHGSAPDIAGQDVANPVSLILSTALLLAWH 312
Query: 363 ------LQLNEHADRVQNACYEVLREGKSLTGDLGG 452
++ E A ++ A + + EG++ T D+GG
Sbjct: 313 GERSGAVRYEEAARAIEAAVAKAIGEGRA-TRDVGG 347
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 123 bits (296), Expect = 4e-27
Identities = 67/164 (40%), Positives = 100/164 (60%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHKAN+++ D F ++A + ++ E +D+ + +V++P V++ N++GD
Sbjct: 161 VHKANVLK-GDRFFREIVLEIAER-EGVEVREAIIDSFMIKLVKNPWDHGVILTENMFGD 218
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD+ + G +G+ PSGN G ALFE +HG+APDIAGK +ANP +LSA MML +L
Sbjct: 219 IISDLATIHAGSIGIVPSGNYGDEIALFEPIHGSAPDIAGKGIANPIGAILSAAMMLDYL 278
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
LN V A +R G +LT D+GGT SE T IIS++
Sbjct: 279 GLNGKV--VWEATRRYVRYG-NLTPDMGGTATTSEVTKGIISEI 319
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 123 bits (296), Expect = 4e-27
Identities = 67/165 (40%), Positives = 102/165 (61%), Gaps = 2/165 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFD--VLVMPNL 176
AV K NI++ +DG+F + A + +DI+ E Y+D + MV +F+ VLV NL
Sbjct: 172 AVTKRNILKQTDGIFWDETQK-AVEGTDIELSEIYIDNMAQQMVIATEQFNGAVLVSTNL 230
Query: 177 YGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
+ DI+S++ S LVG +GL S NIG N A+FE+ HG+AP AG++ NPTA +LS M
Sbjct: 231 FMDIISELASALVGSIGLIYSANIGDNYAMFEAAHGSAPQFAGQNKVNPTATVLSGAWMA 290
Query: 357 RHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIIS 491
+L + D + A +V+ EGK++T D+GG ++ T+AII+
Sbjct: 291 DYLGERDVRDAIFAATEQVINEGKAVTWDIGGDASTTQMTDAIIT 335
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 122 bits (295), Expect = 6e-27
Identities = 67/176 (38%), Positives = 102/176 (57%), Gaps = 7/176 (3%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
A+HKAN M+DGLFL C RD+A + +++ ++ +D ++V+ P +FDVLV N YG
Sbjct: 183 AIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLVATNFYG 242
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR- 359
DI+SD+ S L G LGL S ++ HG+APDIAG+D ANP +++LS M+++
Sbjct: 243 DIISDLASELSGSLGLAGSMMASDTHCCAQAQHGSAPDIAGQDKANPVSMILSVAMLIQW 302
Query: 360 ---HLQLNEH---ADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN*AV 509
H Q + A ++ A VL + T DLGG C + +++K+ AV
Sbjct: 303 MGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAF-GQLVAKVIQAV 357
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 122 bits (295), Expect = 6e-27
Identities = 61/154 (39%), Positives = 101/154 (65%), Gaps = 2/154 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ S L+ + LA++Y D++ Y+D + +++DP +FD +V N++G
Sbjct: 233 SVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFG 291
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD S + G +G+ PS ++G++G LFE +HG+APDIAG+D ANP A +LSA M+L+
Sbjct: 292 DILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLK 351
Query: 360 H-LQLNEHADRVQNACYEVLREGKSLTGDLGGTG 458
+ L + A R+++A + L +G TGD+ G
Sbjct: 352 YGLGEEKAAKRIEDAVVDALNKG-FRTGDIYSPG 384
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 122 bits (294), Expect = 7e-27
Identities = 66/167 (39%), Positives = 106/167 (63%), Gaps = 2/167 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
++ K N++ S L+ + ++A +YSD+ E + +D+ + M+ +P+ FDV+V NL+G
Sbjct: 180 SIDKQNVLATSK-LWRQIAEEVAKEYSDVTLEHQLVDSAAMVMITNPACFDVVVTENLFG 238
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD S L G LG+ PS + ++G +L+E +HG+APDIAGK +ANP +++LS MMLR
Sbjct: 239 DILSDESSVLPGTLGVMPSASHSESGPSLYEPIHGSAPDIAGKGIANPISMILSVAMMLR 298
Query: 360 -HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
A+ +++A + L +G LT DLGG + T AII+ L
Sbjct: 299 DSFGETAGAEMIEHAVNKTLTQG-ILTRDLGGLANTKQMTAAIIANL 344
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 121 bits (292), Expect = 1e-26
Identities = 59/162 (36%), Positives = 98/162 (60%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
A +KANIMR+ D LF++CCR++A+ Y + FE + + +V P +FDV+VMP+LYG
Sbjct: 95 ATYKANIMRLGDCLFIQCCREVASHYPQLSFEGMIVGNTPMQLVSGPQQFDVMVMPSLYG 154
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
+I++++C+GLVGG GL P+ + G+ A+ E+ + ++AN TA LL+ + L +
Sbjct: 155 NIVNNVCTGLVGGAGLVPAASYGQIYAVSETAARQSGKTIASNVANSTATLLAHCIRLDY 214
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAII 488
L+L+ +A ++ A + T D+GG G + II
Sbjct: 215 LKLHFYATSIRTAVLASMENKDIQTPDIGGQGTTLDAIQNII 256
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 121 bits (291), Expect = 2e-26
Identities = 60/162 (37%), Positives = 97/162 (59%), Gaps = 2/162 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFD--VLVMPNLY 179
+HK+NI++++ G FL +A Y +I+ ++D + ++++P F+ VL+ NL+
Sbjct: 172 IHKSNILKLTCGSFLEEVEKVAQDYPNIEVWPYHIDNIAQQLIKNPQIFNKKVLLSTNLF 231
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
D++S+ CS LVG +GL S N+G N A+FE HG+AP AG D NP A +L+ ML
Sbjct: 232 MDVISEECSALVGSIGLIYSANLGDNFAMFEPAHGSAPKYAGLDKVNPVATVLAGAWMLD 291
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAI 485
+L E ++ + A V+ EGK +T D+GG K S+ + I
Sbjct: 292 YLGEKEKSEAIFKATERVISEGKYVTYDVGGNAKLSQMADEI 333
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 120 bits (288), Expect = 4e-26
Identities = 59/170 (34%), Positives = 105/170 (61%), Gaps = 8/170 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHK + ++ G+F+ ++A +Y D++ +E +DT + +++DP +D +V N++GD
Sbjct: 186 VHKNTVFKLGCGMFVDTAYEVAKEYPDVEVDECIVDTFAMRLLRDPWAYDTVVTTNMFGD 245
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
I++D +G+VGGLG+ P IG+ A+ ++ HG+APDIAGK +ANP A++ S M++ H
Sbjct: 246 ILTDEAAGMVGGLGMAPGLCIGRGAKAMAQATHGSAPDIAGKGIANPYAMIESTRMLIEH 305
Query: 363 L-QLNEHADRVQNACY------EVLREGKSLTGDLGGTGKCSEYTNAIIS 491
L + ++ + V+ A Y L + S TGD+ GTG ++ I++
Sbjct: 306 LGRAHDLPEAVRAAAYMREGLDAALADPASRTGDIKGTGGTADMVAGIVA 355
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 119 bits (287), Expect = 5e-26
Identities = 61/170 (35%), Positives = 95/170 (55%), Gaps = 6/170 (3%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
A K I + +DGLF R +A Y +F E D + ++ P ++ V+V PN YG
Sbjct: 170 ATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIVCPNEYG 229
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG------ALFESVHGTAPDIAGKDMANPTALLLSA 344
D +SDM GL+G +GL S + + A+F+ GTAPDIAG++ ANPTA LL+
Sbjct: 230 DFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPTAALLAM 289
Query: 345 IMMLRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISK 494
MLRH+ ++ + ++ A + + G+ T D+GG+ SE+T I+ +
Sbjct: 290 ANMLRHIGEHDSSKALRGALFGAIEAGEK-TADIGGSLNLSEFTQVIVDR 338
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 119 bits (286), Expect = 7e-26
Identities = 61/138 (44%), Positives = 87/138 (63%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K NIM+M+DG+ +A Y DI+ +D + +P FDV+V NLYGDI+
Sbjct: 178 KDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVVVTTNLYGDIV 237
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQL 371
SD+ S G +GLT S NIG A+FE+VHG+APDIAGK++ANP+ LL +A+ ML H+
Sbjct: 238 SDIVSLSSGSIGLTGSANIGDYYAMFEAVHGSAPDIAGKNVANPSGLLNAAVQMLVHIGQ 297
Query: 372 NEHADRVQNACYEVLREG 425
+ A ++NA + L +G
Sbjct: 298 LDKAGVIRNAFLKTLEDG 315
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 118 bits (285), Expect = 9e-26
Identities = 65/171 (38%), Positives = 103/171 (60%), Gaps = 6/171 (3%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ +S L+ +A +Y D++ Y+D + +V+ P +FDV++ NL+G
Sbjct: 197 SVDKANVLEVSQ-LWRERVTAIAAEYPDVELSHLYVDNAAMQLVRWPKQFDVILTENLFG 255
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD + L G +G+ PS ++G +G ++E VHG+APDIAG+D ANP A +LS M+LR
Sbjct: 256 DILSDEAAMLTGSIGMLPSASLGSSGPGVYEPVHGSAPDIAGQDKANPIAQVLSGAMLLR 315
Query: 360 H-LQLNEHADRVQNACYEVLREGKSLTGDLGGTGK----CSEYTNAIISKL 497
+ L + ADR++ A VL +G T D+ G C E I++ L
Sbjct: 316 YSLDQPQAADRIEQAVEAVLAQGYR-TADIYSEGMTLVGCREMGEKILAAL 365
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 118 bits (285), Expect = 9e-26
Identities = 64/172 (37%), Positives = 108/172 (62%), Gaps = 7/172 (4%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRD-LATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLY 179
+V KAN++ S L+ R + +A ++ D++++ +D++ ++++ PS+FDV+V N++
Sbjct: 187 SVDKANVLEPSR-LWRRVAAEVMANEFPDVQYDVVLVDSMAMHLINRPSEFDVVVTGNMF 245
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
GDI++D S L G LG+ PS ++G G L+E +HG+APDIAGK +ANP A +L+A MML
Sbjct: 246 GDILTDEASMLPGSLGMLPSASLGDGGPGLYEPIHGSAPDIAGKSVANPLATILAAAMML 305
Query: 357 RH-LQLNEHADRVQNACYEVLREG----KSLTGDLGGTGKCSEYTNAIISKL 497
RH L L + A+ ++ A V+ +G GD + E A+++KL
Sbjct: 306 RHSLGLTDEAEAIEKAVAGVITDGLRTPDLARGDQSKSVSTEEMGAAVVAKL 357
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 118 bits (284), Expect = 1e-25
Identities = 61/169 (36%), Positives = 102/169 (60%), Gaps = 7/169 (4%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
KAN++R + F ++A +Y DI+ E +D + +++V P+ FDV+V N++GDI+
Sbjct: 192 KANVLR-TYAFFRAVFDEVAKEYPDIEAEHVLVDAMTVHLVNKPTHFDVIVTENMFGDII 250
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL-- 365
SD+ + VGG+G+ PS +G F++ HG+APDIAGK +ANP +L++I+MLR L
Sbjct: 251 SDLGAATVGGMGMAPSEEVGDGIGFFQASHGSAPDIAGKGLANPYGTILASILMLRRLDQ 310
Query: 366 -----QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+L ADR++ A L + T D+GG ++ +A++ +L
Sbjct: 311 RHRDSRLKLGADRIEAAVCAGLEDPALRTRDIGGVAPTNQVVDALLKRL 359
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 118 bits (283), Expect = 2e-25
Identities = 57/147 (38%), Positives = 90/147 (61%), Gaps = 2/147 (1%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K N++R + G+ + + +Y +I +D + + ++P ++ V+V NL+GD++
Sbjct: 220 KPNVLRETSGMMEEVAKQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVI 279
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIA--GKDMANPTALLLSAIMMLRHL 365
SD +GLVGGLG SGNIG A+FE HG+AP A + NP A++LSA MML H+
Sbjct: 280 SDAFAGLVGGLGFAASGNIGDEVAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHI 339
Query: 366 QLNEHADRVQNACYEVLREGKSLTGDL 446
+E ADR++ A +V++EGK T D+
Sbjct: 340 GESEKADRIRKAIADVVKEGKVRTYDM 366
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 116 bits (278), Expect = 6e-25
Identities = 59/168 (35%), Positives = 95/168 (56%), Gaps = 3/168 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
++ K N + S + + +++ +Y D+K +D + M+++P +F+V+V NL+G
Sbjct: 185 SISKGNALNYSMVFWDQIFEEISKEYPDVKTASYLVDAAAMLMIKEPHRFEVVVTSNLFG 244
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG---ALFESVHGTAPDIAGKDMANPTALLLSAIMM 353
DI++D+ + L GGLGL NI ++FE +HG+APDIAG+ +ANP A + SA M
Sbjct: 245 DILTDLGAALAGGLGLAAGANINPERQYPSMFEPIHGSAPDIAGQQIANPLAAIWSASQM 304
Query: 354 LRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L + V +A + L EGK LT D+GGT S+ I+ L
Sbjct: 305 LDFFGYESYGKLVLDALEQTLVEGKVLTPDMGGTASTSDVGKRIVEIL 352
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 116 bits (278), Expect = 6e-25
Identities = 60/157 (38%), Positives = 93/157 (59%), Gaps = 1/157 (0%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ G + D A KY D+K + Y+D V + V++P FDV+V PN++G
Sbjct: 209 SVDKANVLTDIYGFWREVFTDTAAKYPDVKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFG 268
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI++D+ + + GGLGL P GNI G ++FE + G+AP G + NP A + + M+L
Sbjct: 269 DIITDLGAMIQGGLGLAPGGNINPEGTSMFEPMGGSAPKYKGLNKVNPIATIWAGAMLLE 328
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSE 470
HL + A + +A + L+E K T DLGG+ S+
Sbjct: 329 HLGEKQAAAGIVDAIEQNLKEKKIRTYDLGGSAGTSD 365
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 115 bits (277), Expect = 8e-25
Identities = 57/118 (48%), Positives = 76/118 (64%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
KAN ++M + K +I FE Y D + NM+ +P K+ ++ PNLYGDI+
Sbjct: 181 KANAVKMYNLWRSTAMEAAIEKNINISFE--YADALAYNMILNPKKYRYIIAPNLYGDII 238
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
SDM + LVGGLG PS NIG ALFE VHG+APDIAG+DMANP A +++ M+L +L
Sbjct: 239 SDMGAALVGGLGYAPSANIGDKNALFEPVHGSAPDIAGRDMANPAASIMAGSMLLEYL 296
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 113 bits (273), Expect = 3e-24
Identities = 51/135 (37%), Positives = 88/135 (65%), Gaps = 3/135 (2%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
VHK N++ + ++ R + +A +Y ++ + ++D + M DP++FDV+V NL+GD
Sbjct: 315 VHKTNVLVNAGAVWWRITQQVAAEYPEVSVDYMHIDAAMIFMTTDPARFDVIVTDNLFGD 374
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKN---GALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
I++D+ + + GG+GL SGN+ + ++FE VHG+APDIAG+ A+PTA +LSA ++L
Sbjct: 375 IITDLAAAITGGIGLAASGNVNPDRTAPSMFEPVHGSAPDIAGQQKADPTAAILSASLLL 434
Query: 357 RHLQLNEHADRVQNA 401
HL + A ++ A
Sbjct: 435 DHLGYADAAAVIETA 449
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 113 bits (272), Expect = 3e-24
Identities = 58/171 (33%), Positives = 96/171 (56%), Gaps = 3/171 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+ K+N R + L+ +++ ++ D+K+++ +D M+ P+ D +V NL+ D
Sbjct: 187 ITKSNAQRHAMVLWDEIALEISKEFPDVKWDKELVDASTARMINRPATLDTIVATNLHAD 246
Query: 186 IMSDMCSGLVGGLGLTPSGNIG---KNGALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
I+SD+ + L G LG+ P+GNI + ++FE +HG+A DI GK +ANP S +M+L
Sbjct: 247 ILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSVVMLL 306
Query: 357 RHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKLN*AV 509
HL + A RV A V + TGDLGGT ++ T A+ + + AV
Sbjct: 307 EHLGEFDAAQRVMQAVEAVTADTSLHTGDLGGTATTAQVTAAVCAFIENAV 357
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 113 bits (271), Expect = 5e-24
Identities = 59/153 (38%), Positives = 91/153 (59%), Gaps = 8/153 (5%)
Frame = +3
Query: 63 DLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSG 242
++A +Y D+ ++++++D +C V P +FDV+V NL+GDI+SD+ G +G+ PS
Sbjct: 208 EMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSA 267
Query: 243 NIGKN---GALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL-----QLNEHADRVQN 398
N+ +LFE VHG+APDIAGK +ANP A++ SA MM+ L + E D +
Sbjct: 268 NLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGRAREAHDAIVA 327
Query: 399 ACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
A VL+ G T D+GG E +AI++ L
Sbjct: 328 AIEHVLKHGPR-TRDMGGRASTREVGDAIVAHL 359
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 112 bits (269), Expect = 8e-24
Identities = 53/120 (44%), Positives = 79/120 (65%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN+ S F + ++ ++++D+ Y+D L++V+ P +FDVLVM N++GD
Sbjct: 190 VDKANVFT-SLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFDVLVMENMFGD 248
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I+SD+ GLVGG+G+ G IG LF+ HG+APDI G+D ANP A +LSA +ML +L
Sbjct: 249 ILSDLAGGLVGGMGMAACGEIGDTTGLFQPAHGSAPDIMGEDKANPLAAILSAALMLDYL 308
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 111 bits (267), Expect = 1e-23
Identities = 60/150 (40%), Positives = 93/150 (62%), Gaps = 2/150 (1%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ S L+ + ++A + D++ E Y+D + +++ P +FDV++ NL+G
Sbjct: 190 SVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFG 248
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD + L G +GL S ++ G LFE G+APDIAGK +ANP A +LSA +MLR
Sbjct: 249 DILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLR 308
Query: 360 H-LQLNEHADRVQNACYEVLREGKSLTGDL 446
H L+ E A ++ A + L G LTG+L
Sbjct: 309 HSLKQEEAASAIERAVTKALNSG-YLTGEL 337
>UniRef50_Q0LGT0 Cluster: Isocitrate/isopropylmalate
dehydrogenase-like; n=1; Herpetosiphon aurantiacus ATCC
23779|Rep: Isocitrate/isopropylmalate dehydrogenase-like
- Herpetosiphon aurantiacus ATCC 23779
Length = 169
Score = 111 bits (266), Expect = 2e-23
Identities = 51/92 (55%), Positives = 68/92 (73%)
Frame = +3
Query: 171 NLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIM 350
+LYGDI+SD+C+G+VGGLG+ P GNIG++GA+FE+ HG+AP + NPTAL+LS +
Sbjct: 53 HLYGDILSDLCAGMVGGLGVAPGGNIGEHGAVFEATHGSAPKYKNLNKVNPTALILSGEL 112
Query: 351 MLRHLQLNEHADRVQNACYEVLREGKSLTGDL 446
MLRHL E ADR+ A V+ EGK +T DL
Sbjct: 113 MLRHLGEIEAADRLNAAVATVIAEGKDVTYDL 144
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 110 bits (265), Expect = 2e-23
Identities = 54/134 (40%), Positives = 83/134 (61%), Gaps = 3/134 (2%)
Frame = +3
Query: 105 YLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIG---KNGALFES 275
++D + N V P +FDV+V NL+GDI++D+ ++G +G+ S NI + ++FE
Sbjct: 221 HIDALAANFVLKPDEFDVVVASNLFGDILTDLGGAIMGSIGMAASANINPERRYPSMFEP 280
Query: 276 VHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDLGGT 455
VHG+APDIAG+ +ANP + S +ML HL + V +A +VL EG+ T DLGG
Sbjct: 281 VHGSAPDIAGRGIANPVGQIWSVSLMLEHLGRADLGKAVLDAVEDVLEEGRVRTPDLGGR 340
Query: 456 GKCSEYTNAIISKL 497
E T+A+I++L
Sbjct: 341 NTTDEMTDAVIARL 354
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 110 bits (264), Expect = 3e-23
Identities = 61/171 (35%), Positives = 99/171 (57%), Gaps = 7/171 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN+ + + F ++A K+ +++ + Y+D +V+ P FDV+VM N++GD
Sbjct: 200 VDKANVFK-AFAFFRGIFDEIAKKHPEVRTDRLYVDACSAMLVKRPWDFDVMVMENMFGD 258
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMML--- 356
I+SD+ + L+GGLG+ PS +IG A+F+ HGTAPDI G+ ANPT ++LSA MML
Sbjct: 259 IVSDITASLIGGLGMAPSADIGDKYAVFQPCHGTAPDIMGQGKANPTGMILSAAMMLDWI 318
Query: 357 --RH--LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+H E + ++ A +V G + GG+ ++ T A++ L
Sbjct: 319 ADKHGVESAAEAGETIERAVDQVYAGGIK-PMEFGGSNGTADITKAVLGAL 368
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 109 bits (263), Expect = 4e-23
Identities = 55/141 (39%), Positives = 86/141 (60%), Gaps = 3/141 (2%)
Frame = +3
Query: 84 DIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKN-- 257
+++ E Y+D + V+ P +F+V+V NL+GDI+SD+ S +VGGLGL+PS N+
Sbjct: 212 ELQLEAIYIDALVAYFVERPQEFEVVVASNLFGDILSDLGSAIVGGLGLSPSANLNPEKT 271
Query: 258 -GALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSL 434
++FE VHG+APDIAGK +ANP A + S ++L H + + A +VL EG
Sbjct: 272 FPSMFEPVHGSAPDIAGKGIANPIAQIWSLALLLGHQGRKDLEHLIVQAISKVLEEGVVK 331
Query: 435 TGDLGGTGKCSEYTNAIISKL 497
T D+GG ++ +AI ++
Sbjct: 332 TADIGGQATTAQMGDAICQEI 352
>UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Leuconostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 357
Score = 108 bits (259), Expect = 1e-22
Identities = 53/163 (32%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V K+N++ S + + ++ Y D+ + Y+D + + ++ P+ FDV+++PNL+GD
Sbjct: 185 VDKSNVLATSK-FWRKIANEVGKSYQDVTIDYYYVDAMTMAIMAKPTTFDVVIIPNLFGD 243
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGA-LFESVHGTAPDIAGKDMANPTALLLSAIMML-R 359
I+SD + + G +G PS ++G++G L+E +HG+APDIAG+ +ANP +++ + MML
Sbjct: 244 ILSDEAAQITGSIGQIPSMSVGESGPNLYEPIHGSAPDIAGQGIANPISMVNTVAMMLTE 303
Query: 360 HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAII 488
AD++ A + + E +T D+GGT E T ++
Sbjct: 304 SFDEKRIADKI-TAAVDYIIENHCVTPDMGGTMTTDEVTQKMV 345
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 108 bits (259), Expect = 1e-22
Identities = 64/171 (37%), Positives = 97/171 (56%), Gaps = 10/171 (5%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
A+ K N++ LF ++ +Y +I+ + +D +V P +DV V N++G
Sbjct: 190 AIIKDNVLHGCQ-LFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYDVCVTSNMFG 248
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
DI++D+ S L GG+G+ GNIGK+ A+FE +HG+AP AGKD NP A++LS L
Sbjct: 249 DIVTDLASTLQGGMGMAVGGNIGKHNAMFEPIHGSAPKHAGKDKVNPIAMILSVKEGLEW 308
Query: 363 L-------QLNEHADRVQNACYEVLREGKSLTGDLGG---TGKCSEYTNAI 485
L L + A+ ++ A EVL +G++LT DL G KCSE +AI
Sbjct: 309 LAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVGSAI 359
>UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Hypocreales|Rep: 3-isopropylmalate dehydrogenase -
Cephalosporium acremonium (Acremonium chrysogenum)
Length = 380
Score = 107 bits (257), Expect = 2e-22
Identities = 67/177 (37%), Positives = 105/177 (59%), Gaps = 15/177 (8%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDL-ATKYSDIKFEERYLDTVCLNMVQDPSKFD-VLVMPNLYGD 185
KAN++ S L+ R D+ A ++ DI + + D++ + MV+DP +F+ V+ N +GD
Sbjct: 196 KANVLA-SGRLWRRITSDIFAKEFPDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTFGD 254
Query: 186 IMSDMCSGLVGGLGLTPSGNI-------GKNGALFESVHGTAPDIAGKDMANPTALLLSA 344
I+SD+ + G LGL PS ++ ++ ++E VHG+APDI+GK +ANP A +LS
Sbjct: 255 ILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQILSV 314
Query: 345 IMMLRH-LQLNEHADRVQNACYEVL---REG--KSLTGDLGGTGKCSEYTNAIISKL 497
MMLR+ + L + A V+ A +VL EG + TGDLGG CS+ +A+ L
Sbjct: 315 AMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCEVL 371
>UniRef50_Q2Q0B6 Cluster: Putative 3-isopropylmalate dehydrogenase;
n=1; uncultured organism HF10_3D09|Rep: Putative
3-isopropylmalate dehydrogenase - uncultured organism
HF10_3D09
Length = 175
Score = 105 bits (253), Expect = 7e-22
Identities = 61/169 (36%), Positives = 95/169 (56%), Gaps = 7/169 (4%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K+N+ R LF R +A ++ ++ + Y+D + + P +DV+V N++GDI
Sbjct: 1 KSNVTRGCQ-LFRRTFDAVAASHAHVEKDYGYIDAFTQWLTRTPEFYDVVVTSNMFGDIA 59
Query: 192 SDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQL 371
+D+ S L GG+G+ SGNIG + A FE VHG+AP AG++ NP A + S MML L
Sbjct: 60 TDLASVLQGGMGMAASGNIGDDHAFFEPVHGSAPKHAGQNKVNPIASINSVQMMLDWLAR 119
Query: 372 NEHADR-------VQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ D + + E L++G SLT DLGGT C++ +I ++L
Sbjct: 120 RSNDDDLLSVSKILDQSVAEHLKDGSSLTYDLGGTASCTDVGISIANRL 168
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 105 bits (251), Expect = 1e-21
Identities = 59/173 (34%), Positives = 106/173 (61%), Gaps = 8/173 (4%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSK--FDVLVMPNLY 179
V KAN+++ +DG FL R ++ +Y +I F++ ++D + +V + F V+V+PNLY
Sbjct: 189 VTKANVVKTTDGKFLEIARAISKEYPEITFDDWFVDIMAAKLVDTKRRRDFRVIVLPNLY 248
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGK---DMANPTALLLSAIM 350
GDI++D + GG+G S NIGK A+FE++HG+AP + + A+P++++ ++ M
Sbjct: 249 GDILTDEAAEFQGGVGTAGSANIGKRYAMFEAIHGSAPRMVQEGRAQYADPSSIMRASTM 308
Query: 351 MLRHLQLNEHADRVQNACYEVLREGKSL--TGDLGG-TGKCSEYTNAIISKLN 500
+LRH+ + + A +++ A + K L TG GG TG+ E+ + +I +N
Sbjct: 309 LLRHVGMIDKARKLEMALDICGQFEKKLVMTGRPGGATGR--EFADYVIETMN 359
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 105 bits (251), Expect = 1e-21
Identities = 56/167 (33%), Positives = 91/167 (54%), Gaps = 3/167 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V K+N R ++ ++AT++ D+ +++ +D + + M P D +V NL+ D
Sbjct: 187 VTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLDTIVATNLHAD 246
Query: 186 IMSDMCSGLVGGLGLTPSGNIG---KNGALFESVHGTAPDIAGKDMANPTALLLSAIMML 356
I+SD+ L G LG+ P+ NI + ++FE +HG+A DI GK +ANP A +A ML
Sbjct: 247 ILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFWTAAQML 306
Query: 357 RHLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
HL + A R+ +A V G LT D+GGT + T A+ + +
Sbjct: 307 EHLGERDAAARLMSAVERVTEAG-ILTPDVGGTANTRQVTEAVCNAI 352
>UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Helicobacter hepaticus
Length = 357
Score = 104 bits (249), Expect = 2e-21
Identities = 58/154 (37%), Positives = 89/154 (57%), Gaps = 3/154 (1%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN++ S L+ +A Y D+ Y+D + + + PS+FDV++ N++GD
Sbjct: 189 VDKANVLS-SSRLWREVVDKVAQNYKDVHLSYMYVDNAAMQICRAPSQFDVILTENMFGD 247
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGAL--FESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
I+SD S + G +G+ PS ++ NG L +E +HG+APDIAG+D ANP +LSA MML
Sbjct: 248 ILSDEASIITGTIGVIPSASL-SNGTLGMYEPIHGSAPDIAGQDKANPIGTILSAAMMLE 306
Query: 360 -HLQLNEHADRVQNACYEVLREGKSLTGDLGGTG 458
L + ++ +Q A L +G TGD+ G
Sbjct: 307 LSFGLTKESEVIQKAVQNALDKGYR-TGDMMSEG 339
>UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Sordariomycetes|Rep: 3-isopropylmalate dehydrogenase -
Neurospora crassa
Length = 368
Score = 103 bits (248), Expect = 3e-21
Identities = 60/175 (34%), Positives = 104/175 (59%), Gaps = 10/175 (5%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATK-YSDIKFEERYLDTVCLNMVQDPSKFD-VLVMPNL 176
++ KAN++ S L+ + D+ +K + ++ E + +D+ + +V++P + V++ NL
Sbjct: 190 SLDKANVLATSR-LWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNL 248
Query: 177 YGDIMSDMCSGLVGGLGLTPSGNIG-------KNGALFESVHGTAPDIAGKDMANPTALL 335
+GDI+SD S + G +GL PS ++G K ++E +HG+APDI+GK + NP +
Sbjct: 249 FGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTI 308
Query: 336 LSAIMMLRH-LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
LS MMLR+ L L + AD V+ A + G + T DLGG S+ NA++++L
Sbjct: 309 LSVAMMLRYSLNLPKEADAVEAAVKAAIDNG-TKTKDLGGNATTSDMGNAVVAEL 362
>UniRef50_A0Q405 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Francisella tularensis|Rep: 3-isopropylmalate
dehydrogenase - Francisella tularensis subsp. novicida
(strain U112)
Length = 359
Score = 103 bits (247), Expect = 4e-21
Identities = 67/171 (39%), Positives = 99/171 (57%), Gaps = 6/171 (3%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ S L+ ++A Y +K Y+D + MV +PS+FDV+V NL+G
Sbjct: 191 SVDKANVLDTSR-LWRNIVNEVAKDYPSVKVNHMYVDNCAMQMVLNPSQFDVMVTGNLFG 249
Query: 183 DIMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
DI+SD+ S L G +GL PS ++ K+G L+E G+A DI G+ ANP A +LSA +ML
Sbjct: 250 DIISDLASVLPGSIGLVPSISLNKDGFGLYEPSGGSAYDIKGQGKANPIAQILSASLMLS 309
Query: 360 H-LQLNEHADRVQNACYEVLREGKSLTGDL--GGTGKCS--EYTNAIISKL 497
+ L A+ + +A + L +G T D+ GT S E+TN II L
Sbjct: 310 YSFGLVTEAEAIASAINKTLEDG-FRTQDIYTQGTKLASTKEFTNEIIKNL 359
>UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=3; Aquificaceae|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Aquifex aeolicus
Length = 426
Score = 103 bits (247), Expect = 4e-21
Identities = 51/112 (45%), Positives = 69/112 (61%)
Frame = +3
Query: 87 IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGAL 266
+K + D + + +V P +DV++ NL GD +SD+ + L+GG G PSGNIG AL
Sbjct: 280 VKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNIGDGYAL 339
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLRE 422
FES HGTA DIAGK +ANP +L LS MML ++ E A +V +A L E
Sbjct: 340 FESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAE 391
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 103 bits (246), Expect = 5e-21
Identities = 56/157 (35%), Positives = 92/157 (58%), Gaps = 10/157 (6%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLA-TKYSDI--KFEERYL---DTVCLNMVQD----PSKFD 155
+HK N+M+ ++G F + A ++SD + +++ + D + NM Q P ++
Sbjct: 210 MHKGNVMKYTEGAFREWAYETALNEFSDYVSRDDDKKIIINDIIADNMFQQIITRPDEYQ 269
Query: 156 VLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALL 335
+++ PN+ GD +SD L+G +G NIG NGA+FE+VHGTAP AGK++A+P L+
Sbjct: 270 LILAPNVDGDYISDAAGALIGNIGTLGGANIGDNGAMFEAVHGTAPKYAGKNVADPLGLI 329
Query: 336 LSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDL 446
A +MLR++ N AD ++ A + E K +T DL
Sbjct: 330 RGAQLMLRYMGWNRAADAIEKAIQASINE-KKVTNDL 365
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 102 bits (244), Expect = 8e-21
Identities = 62/171 (36%), Positives = 97/171 (56%), Gaps = 9/171 (5%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMP-NLYGDI 188
K+N M +S + + +A Y + ++++++D +C V P +FDV+V+ NL+GDI
Sbjct: 192 KSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVVVVASNLFGDI 251
Query: 189 MSDMCSGLVGGLGLTPSGNIGKNG---ALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
+SD+ G +G+ PS N+ +LFE VHG+APDI GK++ANP A++ S +ML
Sbjct: 252 LSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLE 311
Query: 360 HL-QLNEHADRVQ----NACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L Q +E R NA V+ +G S+T D+GGT + AI L
Sbjct: 312 FLGQGDERYQRAHDDMLNAIERVIADG-SVTPDMGGTLSTQQVGAAISDTL 361
>UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Candidatus Carsonella ruddii PV|Rep: 3-isopropylmalate
dehydrogenase - Carsonella ruddii (strain PV)
Length = 349
Score = 100 bits (240), Expect = 3e-20
Identities = 50/119 (42%), Positives = 81/119 (68%), Gaps = 3/119 (2%)
Frame = +3
Query: 78 YSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNI-GK 254
Y+ +K Y+D ++++++ +KFDV++ NL+GDI+SD+CS L G LG+ PS +I K
Sbjct: 199 YNKVKLSHIYIDYATIDLIKNFNKFDVIITSNLFGDIISDLCSLLTGSLGMLPSISINNK 258
Query: 255 NGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEH--ADRVQNACYEVLREG 425
+ +LFE HG+APDIA K++ANP LLS +MM ++ LN+ ++ + + Y+VL G
Sbjct: 259 SLSLFEPCHGSAPDIANKNIANPVGALLSLVMMFEYV-LNDFKLSNNLYYSIYKVLSYG 316
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 99 bits (238), Expect = 5e-20
Identities = 55/151 (36%), Positives = 88/151 (58%), Gaps = 3/151 (1%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIM 191
K+N M+ L+ +A +Y D+ E+ Y+D + +V++PSKFDV+V NL+ DI+
Sbjct: 187 KSNAMKFGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGSNLFCDII 246
Query: 192 SDMCSGLVGGLGLTPSGNIGKN---GALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
SD+ + G +G+ PS NI +LFE VHG+A DIAGK + +P + ++ MML
Sbjct: 247 SDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRASSMMLEF 306
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGT 455
L +E + ++ A + + K T D+GGT
Sbjct: 307 LGYSEESVLIEEAIQSSILQ-KITTIDIGGT 336
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 99 bits (238), Expect = 5e-20
Identities = 58/169 (34%), Positives = 92/169 (54%), Gaps = 5/169 (2%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V K N ++ + L+ ++A +Y I +D C+ V P +FDV+V NL+GD
Sbjct: 215 VTKRNAVQYAGELWSEVFAEVAAEYPGIATHHELIDACCMKFVSQPWQFDVVVASNLHGD 274
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNG----ALFESVHGTAPDIAGKDMANPTALLLSAIMM 353
I++D+ + L GG+G+ PS N+ LFE HG+APDIAG D A+P A+LL+A M
Sbjct: 275 ILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAM 334
Query: 354 LRHL-QLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L + +++ A R + E + G +GG G C+E A+ ++
Sbjct: 335 LEWMGEVDPVAARSAVQLQRAVAEDIAEHG-MGGRG-CAEVGRAVAQRI 381
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 99 bits (238), Expect = 5e-20
Identities = 52/137 (37%), Positives = 80/137 (58%), Gaps = 1/137 (0%)
Frame = +3
Query: 51 RCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGL 230
R ++ A ++ D+ E +D + + MV +P +FDV++ NL+GDI+SD+ LVG LGL
Sbjct: 253 RLVQEEAAQFPDVIVEPMLVDNLAMQMVMNPQRFDVILASNLFGDILSDIGGALVGSLGL 312
Query: 231 TPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACY 407
S ++ +G L+E++HGTAPDIAGK +ANP + + ++ML A + A
Sbjct: 313 LGSASLNADGFGLYEAIHGTAPDIAGKGIANPLGTIGACVLMLEQWGEKRAAQIIMVAQD 372
Query: 408 EVLREGKSLTGDLGGTG 458
VL +G T DL G
Sbjct: 373 RVLEQGYR-TADLSPQG 388
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 99 bits (238), Expect = 5e-20
Identities = 59/152 (38%), Positives = 91/152 (59%), Gaps = 12/152 (7%)
Frame = +3
Query: 75 KYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNI-- 248
K++D++ E D + +V+ P +FDV++ NL+GD++SD+ + L G LG+ PS ++
Sbjct: 214 KHADVQLEHMLADAGGMQLVRWPKQFDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGA 273
Query: 249 -----GKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH-LQLNEHADRVQNACYE 410
GK AL+E VHG+APDIAGK +ANP A++ S M LR+ L ADR++ A
Sbjct: 274 ADSKTGKRKALYEPVHGSAPDIAGKGIANPIAMIASLAMCLRYSFGLVAEADRLEAAIAG 333
Query: 411 VLREGKSLTGDLGGTGK----CSEYTNAIISK 494
VL +G T D+ G +E +AI++K
Sbjct: 334 VLDDG-IRTADIWSEGNTKVGTTEMGDAILAK 364
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 99.1 bits (236), Expect = 8e-20
Identities = 59/165 (35%), Positives = 89/165 (53%), Gaps = 19/165 (11%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYS-------------------DIKFEERYLDTVCLN 128
VHK NIM+ ++G F +A ++ +I ++ D
Sbjct: 228 VHKGNIMKFTEGAFKEWGYQVAQEFGAELLDGGPWMTLKNPKTGREIIIKDSIADAFLQE 287
Query: 129 MVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGK 308
++ P+++DV+ NL GD +SD + VGG+G++P NIG A+FE+ HGTAP IAG+
Sbjct: 288 ILLHPTEYDVIATLNLNGDYISDALAAQVGGIGISPGANIGAEAAIFEATHGTAPKIAGQ 347
Query: 309 DMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGD 443
D NP +L+LS MMLRHL E AD V A + + + K++T D
Sbjct: 348 DKGNPGSLILSGEMMLRHLGWLEAADLVVKAVSKTIAD-KTVTFD 391
>UniRef50_A1SWV5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Psychromonas ingrahamii 37|Rep: 3-isopropylmalate
dehydrogenase - Psychromonas ingrahamii (strain 37)
Length = 368
Score = 99.1 bits (236), Expect = 8e-20
Identities = 54/160 (33%), Positives = 89/160 (55%), Gaps = 1/160 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
+HK+N+++ S L+ + + Y +++ + +D + +P FDV+VM N++GD
Sbjct: 195 IHKSNVLK-SSVLWNEIVEEESKNYPEVEVKNILVDAAATYLCLNPGMFDVMVMENMFGD 253
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR-H 362
I+SD G++G LGL PS G + + +E HG+APDIAGK +ANP +++ S +ML
Sbjct: 254 ILSDQGGGILGSLGLMPSACKGPDKSYYEPSHGSAPDIAGKGIANPYSMIGSVALMLEMS 313
Query: 363 LQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNA 482
L + A + A V G S T DL G+ + + A
Sbjct: 314 FGLEKEAKNLWAAMQAVFENGYS-TSDLSKEGEANLVSTA 352
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 96.7 bits (230), Expect = 4e-19
Identities = 59/159 (37%), Positives = 87/159 (54%), Gaps = 7/159 (4%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ S ++SD++ Y+D + +V+ PS+FDV+V N++G
Sbjct: 194 SVDKANVLETSVLWREEVTALHEAEFSDVELTHLYVDNAAMQIVRAPSQFDVMVTCNIFG 253
Query: 183 DIMSDMCSGLVGGLGLTPS------GNIGKNGALFESVHGTAPDIAGKDMANPTALLLSA 344
DI+SD + G LG+ PS +G+ AL+E VHG+APDIAGK +ANP +LS
Sbjct: 254 DILSDCAAMASGSLGMLPSVSLGPPDRLGRRKALYEPVHGSAPDIAGKGIANPLGSILSV 313
Query: 345 IMMLR-HLQLNEHADRVQNACYEVLREGKSLTGDLGGTG 458
MMLR L E A ++ A L G + T D+ G
Sbjct: 314 AMMLRITLHRPEDAALLEKAVDTALAAG-ARTADIAEPG 351
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 96.7 bits (230), Expect = 4e-19
Identities = 62/190 (32%), Positives = 100/190 (52%), Gaps = 26/190 (13%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATK-----------YSDIKFEERYLDTVCLNMVQD---- 140
VHK NIM+ ++G F++ LA K + +K + + + +M+ D
Sbjct: 237 VHKGNIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQ 296
Query: 141 -----PSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAG 305
PS++ V+ NL GD +SD + +VGG+G+ P N+ +FE+ HGTAP AG
Sbjct: 297 QILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAG 356
Query: 306 KDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGD----LGGTG--KCS 467
D NP +++LSA MMLRH+ E AD + +A + ++ K +T D + G KCS
Sbjct: 357 LDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIK-SKKVTYDFARLMDGAKEVKCS 415
Query: 468 EYTNAIISKL 497
E+ + +I +
Sbjct: 416 EFASVMIENM 425
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 95.1 bits (226), Expect = 1e-18
Identities = 43/132 (32%), Positives = 78/132 (59%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V KAN++ S L+ + +++A Y ++ + ++D + M+Q+P+ FDV+V N +GD
Sbjct: 185 VDKANVLA-SSRLWRQIAQEMAPNYPEVTTDYMFVDNAAMKMIQEPAFFDVMVTENTFGD 243
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL 365
I++D S + G +GL PS + G++ +FE +HG+ P G ++ANP A +LS M+ +
Sbjct: 244 ILTDEGSVISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSVAMLFEYF 303
Query: 366 QLNEHADRVQNA 401
E ++ A
Sbjct: 304 DCKEEGALIRKA 315
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 94.7 bits (225), Expect = 2e-18
Identities = 61/170 (35%), Positives = 96/170 (56%), Gaps = 19/170 (11%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATK-YSDIKFEE-RYL-------------DTVCLNMVQ- 137
VHK N+++ +DG F R LA K ++ I+ E R+L + + NM+Q
Sbjct: 229 VHKGNVLKFTDGAFKRWGFALAKKEFNAIEHENGRWLKIERAGQAPLIIKEVIADNMLQQ 288
Query: 138 ---DPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGK 308
+P +FDV+ N GD ++DM S VGG+G+ P+ N+ + A FE HGT IAG+
Sbjct: 289 CLMNPEQFDVVATTNQNGDFLADMLSAQVGGVGIMPAANLNNDVAFFEPTHGTFERIAGQ 348
Query: 309 DMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDLGGTG 458
+ ANP++ +LSA++ML+ ++ +E A ++NA L G +T DL G
Sbjct: 349 NKANPSSSILSAVLMLKFMKWDEAALTIENALENTLASG-YVTFDLTQQG 397
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 93.9 bits (223), Expect = 3e-18
Identities = 53/149 (35%), Positives = 88/149 (59%), Gaps = 8/149 (5%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ +S L+ + ++A Y ++K E +D + ++ P+ FDV+V NL+G
Sbjct: 189 SVDKANVL-LSSRLWRQIVIEVAKDYPEVKVEHVLVDACAMKLILAPTYFDVIVTENLFG 247
Query: 183 DIMSDMCSGLVGGLGLTPSGNIG-------KNGALFESVHGTAPDIAGKDMANPTALLLS 341
DI++D S L G +G+ PS ++ K L+E +HG+AP IA +++ANP A +LS
Sbjct: 248 DILTDEASMLAGSMGMLPSASLAGIPAKGTKIFGLYEPIHGSAPTIAKQNIANPIATILS 307
Query: 342 AIMMLRH-LQLNEHADRVQNACYEVLREG 425
MMLR+ L A +++A +VL G
Sbjct: 308 IAMMLRYSCGLETEAVEIESAVDKVLAAG 336
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 93.5 bits (222), Expect = 4e-18
Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 8/143 (5%)
Frame = +3
Query: 87 IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGAL 266
+ +R D++ + P ++ +L NL GD +SD + +VGGLG+ P NIG + A+
Sbjct: 330 VMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGANIGDSAAI 389
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDL 446
FE+ HGTAP AG D NP +++LS +MML + E AD ++ + + +T DL
Sbjct: 390 FEATHGTAPKHAGLDRINPGSVILSGVMMLEFMGWQEAADLIKKGIGAAI-ANREVTYDL 448
Query: 447 GGTG--------KCSEYTNAIIS 491
KCSE+ AI+S
Sbjct: 449 ARLMEPKVDKPLKCSEFAQAIVS 471
>UniRef50_Q5A0M0 Cluster: Putative uncharacterized protein; n=2;
Candida albicans|Rep: Putative uncharacterized protein -
Candida albicans (Yeast)
Length = 116
Score = 92.7 bits (220), Expect = 7e-18
Identities = 52/104 (50%), Positives = 60/104 (57%), Gaps = 1/104 (0%)
Frame = -1
Query: 454 VPPRSPVK-DLPSRSTS*QAFCTRSACSFNWRCLNIMIAERSNAVGFAMSFPAISGAVP* 278
VP +SPV P AF SA F CLNI+ + + AVG A PAISGA P
Sbjct: 12 VPFKSPVSFSGPEAIVFNTAFSISSASEFKDICLNIIQDDNNKAVGLAKPLPAISGAEPW 71
Query: 277 TDSNRAPFLPMLPEGVSPNPPTRPEHMSDMMSPYKLGITKTSNL 146
T S LPMLP+GV P PP +PE SDM+SPYK GIT T+ L
Sbjct: 72 TASKIETLLPMLPDGVKPKPPIKPEDKSDMISPYKFGITMTTFL 115
>UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Saccharomyces cerevisiae (Baker's yeast)
Length = 364
Score = 90.6 bits (215), Expect = 3e-17
Identities = 57/174 (32%), Positives = 103/174 (59%), Gaps = 9/174 (5%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRD-LATKYSDIKFEERYLDTVCLNMVQDPSKFD-VLVMPNL 176
++ KAN++ S L+ + + + ++ +K + + +D+ + +V++P+ + +++ N+
Sbjct: 189 SLDKANVLA-SSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIITSNM 247
Query: 177 YGDIMSDMCSGLVGGLGLTPSGNIG----KNGA--LFESVHGTAPDIAGKDMANPTALLL 338
+GDI+SD S + G LGL PS ++ KN A L+E HG+APD+ K+ NP A +L
Sbjct: 248 FGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLP-KNKVNPIATIL 306
Query: 339 SAIMMLR-HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
SA MML+ L L E +++A +VL G TGDLGG+ +E +A+ ++
Sbjct: 307 SAAMMLKLSLNLPEEGKAIEDAVKKVLDAG-IRTGDLGGSNSTTEVGDAVAEEV 359
>UniRef50_Q0A635 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Alkalilimnicola ehrlichei MLHE-1|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Alkalilimnicola ehrlichei (strain MLHE-1)
Length = 382
Score = 89.0 bits (211), Expect = 8e-17
Identities = 50/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%)
Frame = +3
Query: 66 LATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGN 245
+A ++ ++ +D ++ DP +FDV+V PN++GDI+ D S L+G G++ SGN
Sbjct: 225 VAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPNMFGDILGDCGSLLMGSRGMSWSGN 284
Query: 246 IGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH-LQLNEHADRVQNACYEVLR 419
G G A++++ HG A D+AG+D ANP + S MMLR +L AD ++ A L
Sbjct: 285 YGAAGQAVYQTAHGAAWDLAGRDRANPIGQVCSLAMMLRESFRLPALADALETAIARTLA 344
Query: 420 EGKSLTGDLGGTGKCSEYTNAI 485
G T D+ G + T A+
Sbjct: 345 RGVR-TADIQGAQPTAVGTRAM 365
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 89.0 bits (211), Expect = 8e-17
Identities = 44/141 (31%), Positives = 77/141 (54%), Gaps = 4/141 (2%)
Frame = +3
Query: 87 IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGAL 266
I ++R D + ++ ++DV+ +PNL GD +SD + L+GGLG+ P NIG +
Sbjct: 269 IVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGV 328
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREG---KSLT 437
FE VHG+AP AG++ NPTA +L+ +M ++ + ++ ++ A + G +
Sbjct: 329 FEPVHGSAPKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSGIVTYDIH 388
Query: 438 GDLGGTG-KCSEYTNAIISKL 497
+GGT E+ A++ L
Sbjct: 389 RHMGGTKVGTREFAEAVVENL 409
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 88.6 bits (210), Expect = 1e-16
Identities = 51/141 (36%), Positives = 79/141 (56%), Gaps = 6/141 (4%)
Frame = +3
Query: 96 EERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALFES 275
++R D + ++ ++ V+ NL GD MSD +GGLG+ P N G L E
Sbjct: 321 KDRIADNMLQQLLTRTDEYSVIATMNLNGDYMSDAAGAQIGGLGIAPGINRGHGRCLAEP 380
Query: 276 VHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDL--- 446
VHG+AP AG+D NPTA++LS ML +L ++ AD V++A E + G+ +T DL
Sbjct: 381 VHGSAPKYAGQDKVNPTAMILSGREMLDYLGWSDAADLVRDAVEETISSGQ-VTYDLHRQ 439
Query: 447 --GGTG-KCSEYTNAIISKLN 500
GG SE+ +A++ K++
Sbjct: 440 IEGGEKLATSEFADAVVDKID 460
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 86.6 bits (205), Expect = 4e-16
Identities = 45/133 (33%), Positives = 75/133 (56%), Gaps = 1/133 (0%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V K N++ GL+ R +A Y +K ++D + MV++P FDV+V NL GD
Sbjct: 205 VGKTNVLTYVCGLWERAFNAMAKNYPTVKTAYCHVDAATMWMVKNPEWFDVVVTENLMGD 264
Query: 186 IMSDMCSGLVGGLGLTPSGNIGKNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH 362
I++D+ + GG+G+ GN+ G ++FE + G+AP GK++ NP A + +A MML
Sbjct: 265 IITDLAAMTSGGMGVASGGNLNPKGVSMFEPIGGSAPKYTGKNVINPLAAIGAAAMMLDF 324
Query: 363 LQLNEHADRVQNA 401
L + A ++ +
Sbjct: 325 LGEKDAAKAIEKS 337
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 85.0 bits (201), Expect = 1e-15
Identities = 51/146 (34%), Positives = 80/146 (54%), Gaps = 8/146 (5%)
Frame = +3
Query: 87 IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIG--KNG 260
I ++ D ++ P +FDV+ NL GD +SD + VGG+G+ P GNI
Sbjct: 308 ILIKDAIADITLQQVLTRPEEFDVIATLNLNGDYLSDALAAQVGGIGIAPGGNINYITGH 367
Query: 261 ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTG 440
A+FE+ HGTAP A D NP +++LS MMLR++ E AD + A + + + K +T
Sbjct: 368 AIFEATHGTAPKYANLDRVNPGSVILSGDMMLRYMGWTEAADLIIRALEKTIAQ-KIVTY 426
Query: 441 DLGG--TG----KCSEYTNAIISKLN 500
D TG K S++ +A+I+ ++
Sbjct: 427 DFARLMTGAKEVKTSQFADAMIANMD 452
>UniRef50_Q18WQ3 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=2; Desulfitobacterium hafniense|Rep:
Isocitrate/isopropylmalate dehydrogenase -
Desulfitobacterium hafniense (strain DCB-2)
Length = 374
Score = 84.6 bits (200), Expect = 2e-15
Identities = 47/152 (30%), Positives = 77/152 (50%), Gaps = 7/152 (4%)
Frame = +3
Query: 63 DLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSG 242
+++ Y DI + +D + ++++DP +FDV+ N+ GDI+ D+ + + GG+G+TP+
Sbjct: 212 EVSAGYPDIGLQFTQVDALAEHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTA 271
Query: 243 NIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHL-------QLNEHADRVQNA 401
++G F HGT P GK ANP A +L+A ++L L L A ++ A
Sbjct: 272 DVGGVTPQFRPNHGTFPRAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKA 331
Query: 402 CYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
L G T DLGGT A+ +
Sbjct: 332 VEYNLTTGGPRTKDLGGTANTFATAEAVFKAM 363
>UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 382
Score = 84.2 bits (199), Expect = 2e-15
Identities = 54/169 (31%), Positives = 93/169 (55%), Gaps = 8/169 (4%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFD-VLVMPNLY 179
++ KAN++ S + ++ ++ + + + +D+ + +VQ P+K + +++ N++
Sbjct: 204 SLDKANVLASSRLWRTTVDKVMSEEFPQLTIQHQLIDSAAMILVQSPTKLNGIIITSNMF 263
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGK----NGA--LFESVHGTAPDIAGKDMANPTALLLS 341
GDI+SD S + G LGL PS ++ N A L+E HG+APD+ ++ NP A +LS
Sbjct: 264 GDIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDLT-ENKVNPVATILS 322
Query: 342 AIMMLR-HLQLNEHADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAI 485
MMLR L A+ ++ A +VL G TGDL G+ E +AI
Sbjct: 323 VAMMLRLSLDCVPEAEALEKAVGQVLDSG-IRTGDLRGSSSTKEVGDAI 370
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 81.0 bits (191), Expect = 2e-14
Identities = 41/113 (36%), Positives = 67/113 (59%), Gaps = 2/113 (1%)
Frame = +3
Query: 69 ATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNI 248
A + I ++ D ++ P++ DV+ NL GD +SD + VGG+G+ P NI
Sbjct: 272 AEQEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANI 331
Query: 249 G-KNG-ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNA 401
+ G A+FE+ HGTAP AG + NP++ +LS+++ML HL E AD++ ++
Sbjct: 332 NYETGHAIFEATHGTAPKYAGLNKVNPSSEILSSVLMLEHLGWQEAADKITDS 384
>UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 363
Score = 75.8 bits (178), Expect = 8e-13
Identities = 55/166 (33%), Positives = 89/166 (53%), Gaps = 15/166 (9%)
Frame = +3
Query: 3 AVHKANIM---RMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFD-VLVMP 170
+V KAN+M R+ + RD + D K + +D+ + + +DP K + V++
Sbjct: 181 SVDKANVMATSRLWRQVVTETIRDEFPQLMD-KLSHQLVDSAAMLLAKDPRKLNGVVLTE 239
Query: 171 NLYGDIMSDMCSGLVGGLGLT----------PSGNIGKNGALFESVHGTAPDIAGKDMAN 320
NL+GDI+SD+ S + G LG+ PS + +++ V G+APDIAGK +AN
Sbjct: 240 NLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPDIAGKGIAN 299
Query: 321 PTALLLSAIMMLR-HLQLNEHADRVQNACYEVLREGKSLTGDLGGT 455
P + +S +M R L L + AD + +A + L G+ T D+GGT
Sbjct: 300 PIGMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQ-CTRDVGGT 344
>UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Dikarya|Rep: 3-isopropylmalate dehydrogenase -
Phanerochaete chrysosporium (White-rot fungus)
(Sporotrichumpruinosum)
Length = 380
Score = 75.8 bits (178), Expect = 8e-13
Identities = 53/184 (28%), Positives = 92/184 (50%), Gaps = 19/184 (10%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFD-VLVMPNLY 179
++ KAN++ S + ++ +K + +D+ + +V +P K + V++ NL+
Sbjct: 193 SIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANPKKLNGVILTENLF 252
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGK-----NGA--------LFESVHGTAPDIAGKDMAN 320
GDI+SD S + G LGL PS ++ N A ++E +HG+APDIAG+ +AN
Sbjct: 253 GDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSAPDIAGQGIAN 312
Query: 321 PTALLLSAIMMLRHLQL-NEHADRVQNACYEVLREGKS----LTGDLGGTGKCSEYTNAI 485
P +LSA M+ + A ++ A R+G T DLGG+ K + + +
Sbjct: 313 PIGTILSAAMLCGTRSVWRSPAKAIEAAVEGARRQGDRREGLRTADLGGSSKTKDIGHKV 372
Query: 486 ISKL 497
+ L
Sbjct: 373 VEIL 376
>UniRef50_Q7X199 Cluster: Lfe195p1; n=2; Leptospirillum|Rep:
Lfe195p1 - Leptospirillum ferrooxidans
Length = 197
Score = 72.9 bits (171), Expect = 6e-12
Identities = 36/75 (48%), Positives = 47/75 (62%)
Frame = +3
Query: 273 SVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGDLGG 452
SVHG+AP AG NP+A+LLS +MML+ L +E A R++ +VL E K LT D GG
Sbjct: 3 SVHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNEHEAATRIEKGVDKVLAEAKHLTYDAGG 62
Query: 453 TGKCSEYTNAIISKL 497
T EY +AII +
Sbjct: 63 TASTDEYADAIIKAM 77
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 72.1 bits (169), Expect = 1e-11
Identities = 44/163 (26%), Positives = 83/163 (50%), Gaps = 9/163 (5%)
Frame = +3
Query: 36 DGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLV 215
+GL + A + D+ ++ + +D ++ ++ V+ N GDI+SD+ L
Sbjct: 187 EGLLKEAMDEAARRNPDVPYDPQLIDAAYALLIARATRPLVIPCLNRDGDILSDLVLALY 246
Query: 216 GGLGLTPS------GNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNE 377
G + + S + E+ HGTAP + GK++ANP A+ L+A +L+ + E
Sbjct: 247 GSIAGSESLLIAFDEQFNPRVVMAEAPHGTAPSLQGKNLANPLAMQLAAGALLKQMPDPE 306
Query: 378 H---ADRVQNACYEVLREGKSLTGDLGGTGKCSEYTNAIISKL 497
+ +Q AC + + +G T DLGGT + +E+T+ +I ++
Sbjct: 307 YQRAGAAIQEACLQAVAQGVR-TADLGGTARTTEFTDEVIRRV 348
>UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_03000731;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000731 - Ferroplasma acidarmanus fer1
Length = 377
Score = 68.5 bits (160), Expect = 1e-10
Identities = 43/157 (27%), Positives = 75/157 (47%), Gaps = 5/157 (3%)
Frame = +3
Query: 45 FLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGL 224
F C + A+ D+ +E ++ P F+V+++ N+ + D L G +
Sbjct: 223 FANWCIEEASAQEDVGYEVLKTREFMKRLISSPEDFEVILVDNVLSQTLVDY---LAGTI 279
Query: 225 GLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNAC 404
+ +IG A+FE+V + P AG D A+P + +LS ML H+ E A ++NA
Sbjct: 280 NIEYGSSIGDECAVFEAVQSSLPSEAGYDAADPLSFILSGCEMLMHIGWVEAAQIIENAI 339
Query: 405 YEVLREGKSLTGDLG-----GTGKCSEYTNAIISKLN 500
R+ K + D+ KCSE+++ II ++N
Sbjct: 340 SAAFRDNK-IPKDINTRPDISPIKCSEFSSEIIKRMN 375
>UniRef50_A0FP11 Cluster: Isocitrate/isopropylmalate dehydrogenase
precursor; n=1; Burkholderia phymatum STM815|Rep:
Isocitrate/isopropylmalate dehydrogenase precursor -
Burkholderia phymatum STM815
Length = 253
Score = 59.3 bits (137), Expect = 8e-08
Identities = 26/77 (33%), Positives = 46/77 (59%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYG 182
+V KAN++ S + D++ +Y+D++ Y+D + +V+ P FDV+V N++G
Sbjct: 98 SVDKANVLETSQ-FWKDIMIDVSKEYADVELSHMYVDNAAMQLVKAPKSFDVIVTGNMFG 156
Query: 183 DIMSDMCSGLVGGLGLT 233
DI+SD + L G +G T
Sbjct: 157 DILSDEAAMLTGSIGTT 173
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 56.8 bits (131), Expect = 4e-07
Identities = 27/64 (42%), Positives = 40/64 (62%)
Frame = +3
Query: 6 VHKANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGD 185
V K+N++R S F ++AT+Y ++ + RY D ++V DP +FDVLVM N GD
Sbjct: 191 VDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRFDVLVMENFLGD 249
Query: 186 IMSD 197
I+SD
Sbjct: 250 ILSD 253
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 52.8 bits (121), Expect = 7e-06
Identities = 45/143 (31%), Positives = 69/143 (48%), Gaps = 1/143 (0%)
Frame = +3
Query: 3 AVHK-ANIMRMSDGLFLRCCRDLATKYSDIKFEERYLDTVCLNMVQDPSKFDVLVMPNLY 179
AVH +++D FL C+++A Y +I + E SK +L+
Sbjct: 153 AVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEIASRETRAIRRHSNSK-------SLW 205
Query: 180 GDIMSDMCSGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLR 359
I++++ SG+ GG + G + A+FE V + NP ALL S++MMLR
Sbjct: 206 A-IIANIASGVAGG-------SFGDDYAIFEQVGSVG------NHKNPVALLFSSVMMLR 251
Query: 360 HLQLNEHADRVQNACYEVLREGK 428
HL L ADR++ A V+ EGK
Sbjct: 252 HLLLPLFADRLKTAVTRVISEGK 274
>UniRef50_Q8KH40 Cluster: LeuB; n=2; Buchnera aphidicola|Rep: LeuB -
Buchnera aphidicola
Length = 95
Score = 50.4 bits (115), Expect = 4e-05
Identities = 28/74 (37%), Positives = 48/74 (64%), Gaps = 1/74 (1%)
Frame = +3
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLRH-LQLNEHADRVQNACYEVLREGKSLTGD 443
+E G+APDIAGK++ANP A +LS M++R+ ++L +D++++A + L++G T D
Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYR-TLD 69
Query: 444 LGGTGKCSEYTNAI 485
+ + E TN I
Sbjct: 70 IANDKEKCESTNDI 83
>UniRef50_Q6L1Z1 Cluster: Isocitrate dehydrogenase [NADP]; n=1;
Picrophilus torridus|Rep: Isocitrate dehydrogenase
[NADP] - Picrophilus torridus
Length = 355
Score = 47.6 bits (108), Expect = 3e-04
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 1/80 (1%)
Frame = +3
Query: 261 ALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREG-KSLT 437
+LFES + G D+A+PT+ LL++ MMLR L N+ A ++NA V +G +
Sbjct: 274 SLFESQSRPSFTEEGYDLADPTSFLLASSMMLRRLNFNDAALILRNALNSVYSDGILPAS 333
Query: 438 GDLGGTGKCSEYTNAIISKL 497
+L KCS++ +AI+ ++
Sbjct: 334 LNLNNGLKCSDFIDAIVKRM 353
>UniRef50_Q11SB4 Cluster: Putative uncharacterized protein ttuC;
n=1; Cytophaga hutchinsonii ATCC 33406|Rep: Putative
uncharacterized protein ttuC - Cytophaga hutchinsonii
(strain ATCC 33406 / NCIMB 9469)
Length = 286
Score = 44.8 bits (101), Expect = 0.002
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Frame = +3
Query: 252 KNGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGK- 428
++G + +HG APDI G +ANP ALL++ +L E A +V+N E +
Sbjct: 202 EDGYITMPMHGHAPDIVGMGIANPYALLMAFCRLLTVAGYEELAQQVENQIESAFYENRD 261
Query: 429 SLTGDLGGTGKCSEYTNAIISKLN 500
T D GG +Y ++ +N
Sbjct: 262 QTTPDQGGVLNTEKYMAMMVECIN 285
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 43.2 bits (97), Expect = 0.005
Identities = 36/116 (31%), Positives = 52/116 (44%), Gaps = 9/116 (7%)
Frame = +3
Query: 123 LNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGA-LFESVHGTAPDI 299
+ M+ DP + + NL GDI SD+ + L G L S K+ LFE+ HGTA D+
Sbjct: 429 IKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASSIIESKSSTMLFEAPHGTAHDL 488
Query: 300 -------AGKDM-ANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGD 443
GKD NP+AL+ + L L E + + + + K GD
Sbjct: 489 YLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYSARLKAALKDTVGD 544
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 42.7 bits (96), Expect = 0.007
Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 15/135 (11%)
Frame = +3
Query: 87 IKFEERYLDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKNGAL 266
I +E R +D + M++ F ++ + N GD+ SD+ + G LGL S +G+
Sbjct: 299 IWYEHRLIDDMVAQMIKSEGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSA 357
Query: 267 FES--VHGTA-----PDIAGKDMA-NPTALLLSAIM-MLRHLQLNE------HADRVQNA 401
FES HGT G++ + NP A + + +++ QL+ A+ ++ A
Sbjct: 358 FESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLVQRGQLDNTPDVVTFAEELERA 417
Query: 402 CYEVLREGKSLTGDL 446
C EV+ E +T DL
Sbjct: 418 CIEVVNEEGIMTKDL 432
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 36.7 bits (81), Expect = 0.48
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 14/106 (13%)
Frame = +3
Query: 171 NLYGDIMSDMCSGLVGGLGLTPSGNIGKNGAL-FESVHGTAP-----DIAGKDMA-NPTA 329
N GD+MSDM S G L + S + G +E+ HGT + GK+ + N A
Sbjct: 284 NYDGDVMSDMVSSAFGSLAMMTSVLVSPQGYYEYEAAHGTVQRHYYRHLEGKETSTNSVA 343
Query: 330 LLLSAIMMLR-------HLQLNEHADRVQNACYEVLREGKSLTGDL 446
+ + LR + +L E AD+++ A + GK +T DL
Sbjct: 344 TIFAWTGALRKRGELDGNQKLEEFADKLEKATLSTIESGK-MTKDL 388
>UniRef50_A2R1W4 Cluster: Differential expressed Arsa-7 from patent
US2003215950-A1-Aspergillus niger precursor; n=1;
Aspergillus niger|Rep: Differential expressed Arsa-7
from patent US2003215950-A1-Aspergillus niger precursor
- Aspergillus niger
Length = 406
Score = 36.7 bits (81), Expect = 0.48
Identities = 18/41 (43%), Positives = 23/41 (56%)
Frame = +3
Query: 204 SGLVGGLGLTPSGNIGKNGALFESVHGTAPDIAGKDMANPT 326
SG+ GG G +PSG+ G NGA G AP +G A P+
Sbjct: 362 SGVAGGNGPSPSGSFGGNGAAPSGAAGGAPAASGAPAAAPS 402
>UniRef50_Q2NTK1 Cluster: Putative uncharacterized protein; n=1;
Sodalis glossinidius str. 'morsitans'|Rep: Putative
uncharacterized protein - Sodalis glossinidius (strain
morsitans)
Length = 172
Score = 36.3 bits (80), Expect = 0.63
Identities = 16/33 (48%), Positives = 21/33 (63%)
Frame = -3
Query: 188 DVTVQVGHHQNVELGGILHHVQANGVQVALFEL 90
DVT Q +H + G +LH + NG Q+ALFEL
Sbjct: 49 DVTAQRWYHDFSQCGHLLHEAEINGRQIALFEL 81
>UniRef50_Q4IUS8 Cluster: Putative uncharacterized protein; n=1;
Azotobacter vinelandii AvOP|Rep: Putative uncharacterized
protein - Azotobacter vinelandii AvOP
Length = 1108
Score = 36.3 bits (80), Expect = 0.63
Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 8/64 (12%)
Frame = -2
Query: 294 RELCREQTRIGLRSCLCYRRASAPTPRLDLSTCPT*C-HRTSWASPKR---RT----WRD 139
R + RE+ R G R+C YRR + P R + C R W P+R RT W D
Sbjct: 963 RPVVRERWRPGRRACRRYRRPTPPGARPGAAPWRRRCPSRRCWPPPRRTRDRTIASCWSD 1022
Query: 138 PAPC 127
P PC
Sbjct: 1023 PGPC 1026
>UniRef50_A1D5P0 Cluster: Isocitrate dehydrogenase family protein;
n=3; Trichocomaceae|Rep: Isocitrate dehydrogenase family
protein - Neosartorya fischeri (strain ATCC 1020 / DSM
3700 / NRRL 181)(Aspergillus fischerianus (strain ATCC
1020 / DSM 3700 / NRRL 181))
Length = 558
Score = 35.1 bits (77), Expect = 1.5
Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 1/79 (1%)
Frame = +3
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLR-HLQLNEHADRVQNACYEVLREGKSLTGD 443
+++ HG+A D+ GK + NPTA + +A +L + RV ++ G T D
Sbjct: 270 YQTAHGSADDLLGKGIVNPTATIRAAAAVLEDQAGCSGLKQRVDCVLGDLGARGIG-TPD 328
Query: 444 LGGTGKCSEYTNAIISKLN 500
GGT + A + L+
Sbjct: 329 QGGTATTERFVEAFLQGLD 347
>UniRef50_P12349 Cluster: Period circadian protein; n=45;
Schizophora|Rep: Period circadian protein - Drosophila
virilis (Fruit fly)
Length = 1087
Score = 35.1 bits (77), Expect = 1.5
Identities = 30/107 (28%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Frame = +3
Query: 138 DPSKFDVLVMPNLYGDIMSDMC----SGLVGGLG-LTPSGNIGKNGALFESVHGTAPDIA 302
DP K D + + D +S + SG G G LT + N+ + S GT
Sbjct: 621 DPPKMDSSYVSSAREDALSPVHGFEGSGGSGSSGNLTTASNVRMSSVTNTSNTGTGTS-G 679
Query: 303 GKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREGKSLTGD 443
G++ A+ ++ L M L + LN+H D ++ + RE + TGD
Sbjct: 680 GENSASGSSNPLPVNMTLTEILLNKHNDEMEKCMLKKHRESRGRTGD 726
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 34.7 bits (76), Expect = 1.9
Identities = 39/140 (27%), Positives = 59/140 (42%), Gaps = 16/140 (11%)
Frame = +3
Query: 75 KYSDIKFEERY--LDTVCLNMVQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNI 248
K++D E Y +D +V+ F + N GD+MSDM + G L + S +
Sbjct: 237 KFNDAGIEYFYTLIDDAVARVVKSEGGF-IWACKNYDGDVMSDMVATAFGSLAMMTSVLV 295
Query: 249 GKNGAL-FESVHGTA-----PDIAGK-DMANPTALLLSAIMMLRHL-------QLNEHAD 386
G +E+ HGT + G+ N A L + LR +L E AD
Sbjct: 296 SPEGYYEYEAAHGTVQKHYYQHLKGQLTSTNSMATLFAWTGALRKRGEIDGINELVEFAD 355
Query: 387 RVQNACYEVLREGKSLTGDL 446
R++N + EG +T DL
Sbjct: 356 RLENTSIRTIEEG-IMTKDL 374
>UniRef50_Q13GJ7 Cluster: Transferase, hexapeptide repeat protein;
n=1; Burkholderia xenovorans LB400|Rep: Transferase,
hexapeptide repeat protein - Burkholderia xenovorans
(strain LB400)
Length = 175
Score = 34.3 bits (75), Expect = 2.5
Identities = 15/53 (28%), Positives = 28/53 (52%)
Frame = +3
Query: 267 FESVHGTAPDIAGKDMANPTALLLSAIMMLRHLQLNEHADRVQNACYEVLREG 425
+ S G +P+++G +PTA+L+ + + H + HA + +LREG
Sbjct: 5 YYSFDGVSPEVSGSAFVHPTAVLIGRVTISDHCYIGPHATLRGDGGVILLREG 57
>UniRef50_A1FSL4 Cluster: CarR; n=1; Stenotrophomonas maltophilia
R551-3|Rep: CarR - Stenotrophomonas maltophilia R551-3
Length = 502
Score = 34.3 bits (75), Expect = 2.5
Identities = 18/53 (33%), Positives = 28/53 (52%)
Frame = +2
Query: 143 LQVRRFGDAQLVR*HHVGHVLRSSRGVGADALR*HRQERSPIRVCSRHSSRYR 301
+Q +RF DA+ + HV H LR +R +G + R +R P+R H +R
Sbjct: 249 VQGQRFADARAMARQHVQHALRQAR-LGGQRRQPQRTQRRPLRRLEHHRVAHR 300
>UniRef50_O42913 Cluster: Negative regulator of MBF; n=1;
Schizosaccharomyces pombe|Rep: Negative regulator of MBF
- Schizosaccharomyces pombe (Fission yeast)
Length = 342
Score = 34.3 bits (75), Expect = 2.5
Identities = 16/31 (51%), Positives = 17/31 (54%)
Frame = +2
Query: 257 RSPIRVCSRHSSRYRWKGHGKSDRVTSLSYH 349
R+P R SR SS Y W HGK R SL H
Sbjct: 240 RTPSRTLSRSSSHYLWVRHGKLTRSVSLLQH 270
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 33.9 bits (74), Expect = 3.4
Identities = 42/169 (24%), Positives = 70/169 (41%), Gaps = 22/169 (13%)
Frame = +3
Query: 12 KANIMRMSDGLFLRCCRDLATKY-------SDIKFEERYLDTVCLNMVQDPSKFDVLVMP 170
K I++ DG F +++ K+ + I +E R +D + +++ F V
Sbjct: 251 KNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACK 309
Query: 171 NLYGDIMSDMCSGLVGGLGLTPSGNIGKNGALF--ESVHGTA-----PDIAGKDMA-NPT 326
N GD+ SD+ + G LGL S + +G E+ HGT G+ + NP
Sbjct: 310 NYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPI 369
Query: 327 ALLLSAIMMLRH-------LQLNEHADRVQNACYEVLREGKSLTGDLGG 452
A + + L H L A ++ C E + G ++T DL G
Sbjct: 370 ASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESG-AMTKDLAG 417
>UniRef50_Q4SME7 Cluster: Chromosome 8 SCAF14552, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 8
SCAF14552, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 775
Score = 33.5 bits (73), Expect = 4.4
Identities = 24/78 (30%), Positives = 36/78 (46%)
Frame = -1
Query: 253 LPMLPEGVSPNPPTRPEHMSDMMSPYKLGITKTSNLEGSCTMFRQTVSK*RSSNLMSEYL 74
LP LP S PP R H S + S L + + +EG + R ++S +SS L E
Sbjct: 299 LPPLP---SARPPHRLSHASSITSVQSLPLPEPPKIEGRPSSPRLSISLTKSSTLWRELP 355
Query: 73 VARSRQHLKKRPSDIRMI 20
R+ L++ D R +
Sbjct: 356 GVRNSSELEELTEDQRRL 373
>UniRef50_Q7NIG2 Cluster: Gll2221 protein; n=1; Gloeobacter
violaceus|Rep: Gll2221 protein - Gloeobacter violaceus
Length = 296
Score = 33.5 bits (73), Expect = 4.4
Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 1/95 (1%)
Frame = +3
Query: 66 LATKYSDIKFEERYLDTVCLNMVQDPSKF-DVLVMPNLYGDIMSDMCSGLVGGLGLTPSG 242
LA + +I+F + + V + Q+PSKF + +V + D+ + + L +GL+
Sbjct: 14 LAHCFQEIEFARKQMKNVAFSAAQEPSKFYEFMVRLAHFNDLEGSLIAQLAAAIGLSKH- 72
Query: 243 NIGKNGALFESVHGTAPDIAGKDMANPTALLLSAI 347
LF G PD+A + M + + +AI
Sbjct: 73 -------LFRQ-SGVIPDVADRSMEVASGVFAAAI 99
>UniRef50_Q1Q0V0 Cluster: Similar to pyridoxal phosphate
biosynthetic protein pdxA; n=1; Candidatus Kuenenia
stuttgartiensis|Rep: Similar to pyridoxal phosphate
biosynthetic protein pdxA - Candidatus Kuenenia
stuttgartiensis
Length = 346
Score = 33.5 bits (73), Expect = 4.4
Identities = 16/30 (53%), Positives = 23/30 (76%), Gaps = 3/30 (10%)
Frame = +3
Query: 279 HGTAPDIAGKDMANPTAL---LLSAIMMLR 359
HGTA DIAGK +ANP ++ +++AIMM +
Sbjct: 312 HGTAYDIAGKGIANPDSMKEAIMTAIMMAK 341
>UniRef50_Q5LD27 Cluster: Putative uncharacterized protein; n=1;
Bacteroides fragilis NCTC 9343|Rep: Putative
uncharacterized protein - Bacteroides fragilis (strain
ATCC 25285 / NCTC 9343)
Length = 1667
Score = 33.1 bits (72), Expect = 5.9
Identities = 19/46 (41%), Positives = 27/46 (58%), Gaps = 2/46 (4%)
Frame = +3
Query: 210 LVGGLGLTPSGNIGKNGALFESVHG--TAPDIAGKDMANPTALLLS 341
++GG G + GNI NG L+E+ +G T PD+ A PT +LS
Sbjct: 569 VIGGGGSSGGGNIMLNGTLYEAANGVITLPDLKS---AEPTYFMLS 611
>UniRef50_Q2CHG7 Cluster: Parallel beta-helix repeat protein; n=4;
cellular organisms|Rep: Parallel beta-helix repeat
protein - Oceanicola granulosus HTCC2516
Length = 3143
Score = 33.1 bits (72), Expect = 5.9
Identities = 21/46 (45%), Positives = 25/46 (54%), Gaps = 3/46 (6%)
Frame = +2
Query: 185 HHVGHVLRSSRGVGADALR*HRQERSPIRVCSR---HSSRYRWKGH 313
HH+G V R GVG D LR R+ P RV R H +R R +GH
Sbjct: 2350 HHLGRVGRRDGGVGVD-LRQLRRRHDPRRVRHRGDHHRARRRRRGH 2394
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 33.1 bits (72), Expect = 5.9
Identities = 12/19 (63%), Positives = 15/19 (78%)
Frame = +3
Query: 3 AVHKANIMRMSDGLFLRCC 59
AVHK NI ++ DG FL+CC
Sbjct: 85 AVHKVNITKLGDGPFLQCC 103
>UniRef50_UPI0000F1E8DC Cluster: PREDICTED: similar to B-cell
linker; n=1; Danio rerio|Rep: PREDICTED: similar to
B-cell linker - Danio rerio
Length = 390
Score = 32.7 bits (71), Expect = 7.7
Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Frame = -1
Query: 304 PAISGAVP*TDSNRAPFLP-MLPEGVSPNPPTRPEHMSDMMS 182
P++SG +P N P LP ++P+ P+PPT P S +S
Sbjct: 223 PSLSGPLPPPTPNSKPVLPIIMPKEPKPSPPTPPSLDSTALS 264
>UniRef50_A1B0Y4 Cluster: Putative uncharacterized protein; n=1;
Paracoccus denitrificans PD1222|Rep: Putative
uncharacterized protein - Paracoccus denitrificans
(strain Pd 1222)
Length = 140
Score = 32.7 bits (71), Expect = 7.7
Identities = 24/62 (38%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Frame = -2
Query: 282 REQTRIGLRSCLCYRRASAPTPR-LDLSTCPT*CHRTS-WASPKRRTWRDPAPCSGKRCP 109
R + RI L CL +R+ S+ PR + L TCP T+ W P R+W +P S R P
Sbjct: 66 RAEGRILLAQCLVFRKNSSRLPRIIGLITCPLKRPPTARWIVP-LRSWIS-SPASESRSP 123
Query: 108 SS 103
S
Sbjct: 124 RS 125
>UniRef50_Q7PDQ3 Cluster: ERYTHROCYTE MEMBRANE PROTEIN PFEMP3; n=1;
Plasmodium yoelii yoelii|Rep: ERYTHROCYTE MEMBRANE
PROTEIN PFEMP3 - Plasmodium yoelii yoelii
Length = 1318
Score = 32.7 bits (71), Expect = 7.7
Identities = 15/42 (35%), Positives = 21/42 (50%)
Frame = +3
Query: 132 VQDPSKFDVLVMPNLYGDIMSDMCSGLVGGLGLTPSGNIGKN 257
+ FD PNL G++ ++ L G LG SGN+G N
Sbjct: 287 INSQKMFDKAFSPNLSGNLSGNLSGNLGGNLGGNLSGNLGGN 328
>UniRef50_Q6C8U9 Cluster: Yarrowia lipolytica chromosome D of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome D of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 1036
Score = 32.7 bits (71), Expect = 7.7
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 3/59 (5%)
Frame = +3
Query: 255 NGALFESVHGTAPDIAGKDMANPTALLLSAIMMLRH---LQLNEHADRVQNACYEVLRE 422
+G FE +HG+ P++AGK + T L A + +H QL+E+ V+ C + L++
Sbjct: 341 DGTKFEVLHGSEPELAGKTL---TVLKRLAEELQKHGDQSQLDEYLTNVETDCMDKLKD 396
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 696,070,502
Number of Sequences: 1657284
Number of extensions: 14935705
Number of successful extensions: 42633
Number of sequences better than 10.0: 143
Number of HSP's better than 10.0 without gapping: 40438
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 42505
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 48126133708
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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