Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= FWDP01_T7_A16
(819 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U17857-1|AAA85687.1| 752|Homo sapiens hMLH1 protein. 159 8e-39
U40978-1|AAA82079.1| 756|Homo sapiens DNA mismatch repair prote... 156 8e-38
U07418-1|AAA17374.1| 756|Homo sapiens hmlh1 protein. 156 8e-38
U07343-1|AAC50285.1| 756|Homo sapiens DNA mismatch repair prote... 156 8e-38
BC006850-1|AAH06850.1| 756|Homo sapiens mutL homolog 1, colon c... 156 8e-38
AY517558-1|AAT44531.1| 755|Homo sapiens hypothetical rhabdomyos... 156 8e-38
AY217549-1|AAO22994.1| 756|Homo sapiens mutL homolog 1, colon c... 156 8e-38
AK222810-1|BAD96530.1| 756|Homo sapiens MutL protein homolog 1 ... 156 8e-38
AB209848-1|BAD93085.1| 552|Homo sapiens MutL protein homolog 1 ... 66 1e-10
AY344475-1|AAQ23474.1| 38|Homo sapiens mutant mismatch repair ... 37 0.10
>U17857-1|AAA85687.1| 752|Homo sapiens hMLH1 protein.
Length = 752
Score = 159 bits (387), Expect = 8e-39
Identities = 86/228 (37%), Positives = 127/228 (55%), Gaps = 9/228 (3%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 --------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 752
>U40978-1|AAA82079.1| 756|Homo sapiens DNA mismatch repair protein
homolog protein.
Length = 756
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>U07418-1|AAA17374.1| 756|Homo sapiens hmlh1 protein.
Length = 756
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>U07343-1|AAC50285.1| 756|Homo sapiens DNA mismatch repair protein
homolog protein.
Length = 756
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>BC006850-1|AAH06850.1| 756|Homo sapiens mutL homolog 1, colon
cancer, nonpolyposis type 2 (E. coli) protein.
Length = 756
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>AY517558-1|AAT44531.1| 755|Homo sapiens hypothetical
rhabdomyosarcoma antigen MU-RMS-40.5 protein.
Length = 755
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 526 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 585
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 586 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 643
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 644 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 703
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 704 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 755
>AY217549-1|AAO22994.1| 756|Homo sapiens mutL homolog 1, colon
cancer, nonpolyposis type 2 (E. coli) protein.
Length = 756
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>AK222810-1|BAD96530.1| 756|Homo sapiens MutL protein homolog 1
variant protein.
Length = 756
Score = 156 bits (379), Expect = 8e-38
Identities = 86/232 (37%), Positives = 127/232 (54%), Gaps = 13/232 (5%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 527 NHSFVGCVNPQWALAQHQTKLYLLNATKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 586
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVNGEGEXXXXXXXLD 375
+L L+ + S E G +A+++ + L K ML +YFSLE++ EG +D
Sbjct: 587 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLTGLPLLID 644
Query: 374 GHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQPNPDPNVESVSSEHRRQ- 198
+ P + LP +++RL TEVNWD EKECFE+ ++ A FY+ + ES S + +
Sbjct: 645 NYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEV 704
Query: 197 ------------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 705 PGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 756
>AB209848-1|BAD93085.1| 552|Homo sapiens MutL protein homolog 1
variant protein.
Length = 552
Score = 66.1 bits (154), Expect = 1e-10
Identities = 37/107 (34%), Positives = 57/107 (53%)
Frame = -2
Query: 734 NXXFIARIDCHKSLIQHXTKLYLCDXXXXXXXXXXXXXLYDFQNFGFIKLSNPLPLEELF 555
N F+ ++ +L QH TKLYL + +YDF NFG ++LS P PL +L
Sbjct: 392 NHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLA 451
Query: 554 VLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFSLEVN 414
+L L+ + S E G +A+++ + L K ML +YFSLE++
Sbjct: 452 MLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEID 496
Score = 58.0 bits (134), Expect = 4e-08
Identities = 23/40 (57%), Positives = 31/40 (77%)
Frame = -2
Query: 197 EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFERC 78
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFERC
Sbjct: 513 EHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC 552
>AY344475-1|AAQ23474.1| 38|Homo sapiens mutant mismatch repair
protein protein.
Length = 38
Score = 36.7 bits (81), Expect = 0.10
Identities = 13/22 (59%), Positives = 17/22 (77%)
Frame = -2
Query: 317 VNWDSEKECFETFCRQTAKFYA 252
VNWD EKECFE+ ++ A FY+
Sbjct: 1 VNWDEEKECFESLSKEGAMFYS 22
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 104,165,129
Number of Sequences: 237096
Number of extensions: 2080461
Number of successful extensions: 7263
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7157
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7246
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10203625794
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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