Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= FWDP01_FL5_C01
(841 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 159 9e-39
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 159 9e-39
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 159 9e-39
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 159 9e-39
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 159 9e-39
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 159 9e-39
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 159 9e-39
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 142 1e-33
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 142 1e-33
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 142 1e-33
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 142 1e-33
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 132 2e-30
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 132 2e-30
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 125 2e-28
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 125 2e-28
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 125 2e-28
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 125 2e-28
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 125 2e-28
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 125 2e-28
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 125 2e-28
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 125 2e-28
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 125 2e-28
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 120 9e-27
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 120 9e-27
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 118 3e-26
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 118 3e-26
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 118 3e-26
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 118 3e-26
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 118 3e-26
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 118 3e-26
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 118 3e-26
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 118 3e-26
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 118 3e-26
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 118 3e-26
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 118 3e-26
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 118 3e-26
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 118 3e-26
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 118 3e-26
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 71 4e-12
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 1e-08
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 56 2e-07
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 56 2e-07
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 56 2e-07
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 56 2e-07
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 56 2e-07
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 56 2e-07
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 56 2e-07
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 56 2e-07
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 56 2e-07
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 56 2e-07
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 56 2e-07
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 53 1e-06
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 44 0.001
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 44 0.001
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 44 0.001
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 44 0.001
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 44 0.001
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 44 0.001
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 44 0.001
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 44 0.001
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 44 0.001
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 44 0.001
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.003
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 42 0.003
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.003
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 41 0.005
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 39 0.020
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.026
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 37 0.10
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 32 2.3
AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens ... 32 3.0
BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain cont... 31 6.9
BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member ... 25 8.6
AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens ... 25 8.6
BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated prot... 30 9.1
BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated prot... 30 9.1
AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated prot... 30 9.1
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 159 bits (387), Expect = 9e-39
Identities = 83/148 (56%), Positives = 97/148 (65%), Gaps = 11/148 (7%)
Frame = +1
Query: 178 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 324
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTV 588
YV NGT F I YGSGSLSG+LS D V+V
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
Score = 30.7 bits (66), Expect = 6.9
Identities = 15/30 (50%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 593 GLKVRRQTFAEAVSXPGLP-SXRQFDGISG 679
G+KV RQ F EA PG+ +FDGI G
Sbjct: 171 GVKVERQVFGEATKQPGITFIAAKFDGILG 200
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 142 bits (345), Expect = 1e-33
Identities = 67/141 (47%), Positives = 93/141 (65%), Gaps = 5/141 (3%)
Frame = +1
Query: 187 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 351
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 352 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 531
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 532 IQYGSGSLSGFLSTDDVTVGG 594
IQYG+G + G LS D +T+GG
Sbjct: 139 IQYGTGRVDGILSEDKLTIGG 159
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 142 bits (344), Expect = 1e-33
Identities = 67/141 (47%), Positives = 93/141 (65%), Gaps = 5/141 (3%)
Frame = +1
Query: 187 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 351
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 352 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 531
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 532 IQYGSGSLSGFLSTDDVTVGG 594
IQYG+G + G LS D +T+GG
Sbjct: 139 IQYGTGRVDGILSEDKLTIGG 159
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 142 bits (344), Expect = 1e-33
Identities = 67/141 (47%), Positives = 93/141 (65%), Gaps = 5/141 (3%)
Frame = +1
Query: 187 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 351
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 352 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 531
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 532 IQYGSGSLSGFLSTDDVTVGG 594
IQYG+G + G LS D +T+GG
Sbjct: 139 IQYGTGRVDGILSEDKLTIGG 159
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 142 bits (344), Expect = 1e-33
Identities = 67/141 (47%), Positives = 93/141 (65%), Gaps = 5/141 (3%)
Frame = +1
Query: 187 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 351
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 352 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 531
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 532 IQYGSGSLSGFLSTDDVTVGG 594
IQYG+G + G LS D +T+GG
Sbjct: 139 IQYGTGRVDGILSEDKLTIGG 159
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 132 bits (318), Expect = 2e-30
Identities = 61/134 (45%), Positives = 88/134 (65%), Gaps = 5/134 (3%)
Frame = +1
Query: 208 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 372
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 373 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 552
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 141
Query: 553 LSGFLSTDDVTVGG 594
+ G LS D +T+GG
Sbjct: 142 VDGILSEDKLTIGG 155
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 132 bits (318), Expect = 2e-30
Identities = 61/134 (45%), Positives = 88/134 (65%), Gaps = 5/134 (3%)
Frame = +1
Query: 208 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 372
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 373 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 552
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 145
Query: 553 LSGFLSTDDVTVGG 594
+ G LS D +T+GG
Sbjct: 146 VDGILSEDKLTIGG 159
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 125 bits (301), Expect = 2e-28
Identities = 53/90 (58%), Positives = 68/90 (75%)
Frame = +1
Query: 325 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 504
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 505 YVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGG 167
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 120 bits (288), Expect = 9e-27
Identities = 67/154 (43%), Positives = 88/154 (57%), Gaps = 12/154 (7%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 318
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 319 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 492
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 493 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
S TY + +I YG+GS++G L D V VGG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGG 155
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 120 bits (288), Expect = 9e-27
Identities = 67/154 (43%), Positives = 88/154 (57%), Gaps = 12/154 (7%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 318
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 319 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 492
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 493 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
S TY + +I YG+GS++G L D V VGG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGG 155
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 118 bits (284), Expect = 3e-26
Identities = 66/141 (46%), Positives = 87/141 (61%), Gaps = 9/141 (6%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 358 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 537
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 538 YGSGSLSGFLSTDDVTVGGAQ 600
YGSGSL+GF D +TV Q
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQ 154
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 118 bits (284), Expect = 3e-26
Identities = 66/154 (42%), Positives = 88/154 (57%), Gaps = 12/154 (7%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 318
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 319 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 492
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 493 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
S TY + +I YG+GS++G L D V VGG
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGG 155
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 118 bits (284), Expect = 3e-26
Identities = 66/141 (46%), Positives = 87/141 (61%), Gaps = 9/141 (6%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 358 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 537
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 538 YGSGSLSGFLSTDDVTVGGAQ 600
YGSGSL+GF D +TV Q
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQ 154
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 118 bits (284), Expect = 3e-26
Identities = 66/141 (46%), Positives = 87/141 (61%), Gaps = 9/141 (6%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 358 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 537
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 538 YGSGSLSGFLSTDDVTVGGAQ 600
YGSGSL+GF D +TV Q
Sbjct: 131 YGSGSLTGFFGYDTLTVQSIQ 151
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 118 bits (284), Expect = 3e-26
Identities = 66/141 (46%), Positives = 87/141 (61%), Gaps = 9/141 (6%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 358 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 537
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 538 YGSGSLSGFLSTDDVTVGGAQ 600
YGSGSL+GF D +TV Q
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQ 154
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 118 bits (284), Expect = 3e-26
Identities = 66/141 (46%), Positives = 87/141 (61%), Gaps = 9/141 (6%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 358 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 537
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 538 YGSGSLSGFLSTDDVTVGGAQ 600
YGSGSL+GF D +TV Q
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQ 154
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 118 bits (284), Expect = 3e-26
Identities = 66/141 (46%), Positives = 87/141 (61%), Gaps = 9/141 (6%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 358 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 537
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 538 YGSGSLSGFLSTDDVTVGGAQ 600
YGSGSL+GF D +TV Q
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQ 154
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 118 bits (283), Expect = 3e-26
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 10/152 (6%)
Frame = +1
Query: 169 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 318
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 319 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 498
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 499 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
TY G F+IQYG+GSLSG + D V+V G
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEG 157
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 71.3 bits (167), Expect = 4e-12
Identities = 29/60 (48%), Positives = 41/60 (68%)
Frame = +1
Query: 415 SNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 594
SN+WVPS KC AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG 60
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 1e-08
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +1
Query: 205 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 357
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 358 VISIGTPPQSFKVVFDTGSSNL 423
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 67 TVKYTQGSWTGFVGEDLVTI 86
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 55.6 bits (128), Expect = 2e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 52.8 bits (121), Expect = 1e-06
Identities = 27/74 (36%), Positives = 40/74 (54%)
Frame = +1
Query: 367 IGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGS 546
IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQ 56
Query: 547 GSLSGFLSTDDVTV 588
GS +GF+ D VT+
Sbjct: 57 GSWTGFVGEDLVTI 70
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 115
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 116 YVPYTQGKWEGELGTDLVSI 135
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 43.6 bits (98), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 159
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 160 YVPYTQGKWEGELGTDLVSI 179
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.003
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTD 576
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 41.9 bits (94), Expect = 0.003
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTD 576
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.003
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTD 576
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 41.1 bits (92), Expect = 0.005
Identities = 25/80 (31%), Positives = 38/80 (47%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 528
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLFSTYRDLRKGV 128
Query: 529 AIQYGSGSLSGFLSTDDVTV 588
+ Y G G L TD V++
Sbjct: 129 YVPYTQGKWEGELGTDLVSI 148
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 39.1 bits (87), Expect = 0.020
Identities = 21/66 (31%), Positives = 34/66 (51%)
Frame = +1
Query: 391 KVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLS 570
+++ DTGSSN V Y + +D+ +S TY + G ++Y GS +GF+
Sbjct: 3 QILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVG 56
Query: 571 TDDVTV 588
D VT+
Sbjct: 57 EDLVTI 62
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.026
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +1
Query: 196 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 348
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 349 YYGVISIGTP 378
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 36.7 bits (81), Expect = 0.10
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +1
Query: 349 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTY 507
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 32.3 bits (70), Expect = 2.3
Identities = 13/33 (39%), Positives = 16/33 (48%)
Frame = -1
Query: 571 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC 473
W GS+R C + V + S SW CR CC
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCC 40
>AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens
cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC
2.7.7.6). ).
Length = 260
Score = 31.9 bits (69), Expect = 3.0
Identities = 17/35 (48%), Positives = 18/35 (51%)
Frame = -1
Query: 580 HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTC 476
H+ W GS R C S T S G HS SWT R C
Sbjct: 26 HNSWTGSNRACSSWTGSTRG-HS---SWTGSSRAC 56
>BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain
containing 11 protein.
Length = 514
Score = 30.7 bits (66), Expect = 6.9
Identities = 12/26 (46%), Positives = 18/26 (69%)
Frame = -2
Query: 414 GSGVEYHLERLRRRADTDHSVVLSIK 337
G G E+HLER+RR ++++ SIK
Sbjct: 30 GQGAEHHLERIRRSHQKHNAILASIK 55
>BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member 12
protein.
Length = 578
Score = 25.4 bits (53), Expect(2) = 8.6
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -1
Query: 340 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 188
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 8.6
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -1
Query: 487 CRTCCAANKRCWCSGTFWKAPRGWRIR 407
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ10260 fis, clone HEMBB1000973, moderately
similar to Mus musculus schlafen3 mRNA. ).
Length = 578
Score = 25.4 bits (53), Expect(2) = 8.6
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -1
Query: 340 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 188
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINASLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 8.6
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -1
Query: 487 CRTCCAANKRCWCSGTFWKAPRGWRIR 407
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 9.1
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 565 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 446
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 9.1
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 565 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 446
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated protein
protein.
Length = 129
Score = 30.3 bits (65), Expect = 9.1
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 565 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 446
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 116,747,654
Number of Sequences: 237096
Number of extensions: 2513446
Number of successful extensions: 5097
Number of sequences better than 10.0: 77
Number of HSP's better than 10.0 without gapping: 4769
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5058
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10593928420
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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