Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 030725E6_E04_e509_10.seq
(1534 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q12882 Cluster: Dihydropyrimidine dehydrogenase [NADP+]... 421 e-116
UniRef50_A0CDX9 Cluster: Chromosome undetermined scaffold_17, wh... 267 6e-70
UniRef50_A2ELU8 Cluster: Dihydroorotate dehydrogenase family pro... 235 2e-60
UniRef50_UPI000049A38F Cluster: dihydropyrimidine dehydrogenase;... 228 3e-58
UniRef50_Q23YG3 Cluster: Dihydroorotate dehydrogenase family pro... 221 4e-56
UniRef50_Q39PB0 Cluster: Dihydroorotate dehydrogenase 1; n=81; B... 182 2e-44
UniRef50_Q9LVI9 Cluster: Senescencs-related protein; dihydroorot... 169 2e-40
UniRef50_Q099I4 Cluster: Dihydropyrimidine dehydrogenase; n=1; S... 161 4e-38
UniRef50_A0W5K9 Cluster: Dihydroorotate dehydrogenase family pro... 147 6e-34
UniRef50_A5VL42 Cluster: Dihydroorotate dehydrogenase family pro... 142 2e-32
UniRef50_P25889 Cluster: Uncharacterized protein yeiA; n=22; Bac... 138 4e-31
UniRef50_Q972L2 Cluster: 350aa long hypothetical dihydroorotate ... 132 3e-29
UniRef50_Q1F0W8 Cluster: Dihydroorotate dehydrogenase 1; n=1; Cl... 113 1e-23
UniRef50_Q1G992 Cluster: Dihydroorotate dehydrogenase; n=3; Lact... 108 3e-22
UniRef50_Q979G6 Cluster: Dihydroorotate dehydrogenase; n=4; Ther... 108 4e-22
UniRef50_Q8PW56 Cluster: Dihydroorotate dehydrogenase; n=14; Eur... 105 3e-21
UniRef50_Q67PZ8 Cluster: Dihydroorotate dehydrogenase catalytic ... 99 2e-19
UniRef50_Q47741 Cluster: Dihydroorotate dehydrogenase B, catalyt... 99 4e-19
UniRef50_Q9V0Y6 Cluster: Dihydroorotate dehydrogenase; n=8; Eury... 97 8e-19
UniRef50_Q8G660 Cluster: Dihydroorotate dehydrogenase; n=4; Bifi... 97 1e-18
UniRef50_Q3AC05 Cluster: Dihydroorotate dehydrogenase, catalytic... 90 2e-16
UniRef50_Q1Q4L5 Cluster: Similar to dihydroorotate oxidase (Dihy... 89 3e-16
UniRef50_Q73P17 Cluster: Dihydroorotate dehydrogenase/oxidoreduc... 87 1e-15
UniRef50_A7DP74 Cluster: Dihydroorotate dehydrogenase family pro... 86 2e-15
UniRef50_Q8TXU6 Cluster: Dihydroorotate dehydrogenase; n=1; Meth... 86 3e-15
UniRef50_A6G037 Cluster: Dihydroorotate dehydrogenase 1; n=1; Pl... 84 8e-15
UniRef50_Q9K9W1 Cluster: Dihydroorotate dehydrogenase; n=1; Baci... 84 8e-15
UniRef50_A4A2Y8 Cluster: Dihydroorotate dehydrogenase; n=3; Plan... 84 1e-14
UniRef50_A0Z3E6 Cluster: Dihydroorotate dehydrogenase/oxidoreduc... 83 1e-14
UniRef50_Q1MQG1 Cluster: Dihydroorotate dehydrogenase; n=2; Delt... 83 2e-14
UniRef50_Q2NEG1 Cluster: PyrD; n=1; Methanosphaera stadtmanae DS... 81 1e-13
UniRef50_Q9YFI6 Cluster: Dihydroorotate dehydrogenase; n=3; Desu... 81 1e-13
UniRef50_A0LD69 Cluster: Dihydroorotate dehydrogenase family pro... 80 2e-13
UniRef50_A5FPW7 Cluster: Dihydroorotate dehydrogenase family pro... 79 2e-13
UniRef50_A0RV22 Cluster: Dihydroorotate dehydrogenase; n=1; Cena... 79 3e-13
UniRef50_Q8KC29 Cluster: Dihydroorotate dehydrogenase; n=10; Chl... 78 5e-13
UniRef50_Q1IUQ6 Cluster: Dihydroorotate dehydrogenase family pro... 77 1e-12
UniRef50_UPI00015BD53C Cluster: UPI00015BD53C related cluster; n... 77 2e-12
UniRef50_Q64TN0 Cluster: Dihydroorotate dehydrogenase; n=6; Bact... 76 3e-12
UniRef50_Q891J3 Cluster: Dihydroorotate dehydrogenase; n=16; Bac... 74 9e-12
UniRef50_A6L5H1 Cluster: Dihydroorotate dehydrogenase; n=1; Bact... 73 3e-11
UniRef50_A5NSG9 Cluster: Dihydroorotate dehydrogenase family pro... 71 6e-11
UniRef50_A1RZC9 Cluster: Dihydroorotate dehydrogenase family pro... 70 1e-10
UniRef50_A6LJ97 Cluster: Dihydroorotate dehydrogenase family pro... 69 3e-10
UniRef50_A3DL41 Cluster: Dihydroorotate dehydrogenase family pro... 69 4e-10
UniRef50_O29513 Cluster: Dihydroorotate dehydrogenase; n=1; Arch... 67 1e-09
UniRef50_Q1AVZ1 Cluster: Dihydroorotate dehydrogenase family pro... 63 2e-08
UniRef50_A4M861 Cluster: Dihydroorotate dehydrogenase family pro... 62 4e-08
UniRef50_A3DM44 Cluster: Dihydroorotate dehydrogenase family pro... 56 2e-06
UniRef50_Q8A841 Cluster: Putative dihydropyrimidine dehydrogenas... 55 6e-06
UniRef50_O08358 Cluster: Dihydroorotate dehydrogenase; n=4; Sulf... 54 1e-05
UniRef50_Q7MTB7 Cluster: Dihydroorotate dehydrogenase family pro... 53 2e-05
UniRef50_A2EKA7 Cluster: Dihydroorotate dehydrogenase family pro... 52 3e-05
UniRef50_Q54XQ6 Cluster: Putative uncharacterized protein; n=1; ... 52 4e-05
UniRef50_A0ZZT0 Cluster: Putative uncharacterized protein; n=2; ... 51 7e-05
UniRef50_A4FBL7 Cluster: Dihydroorotate dehydrogenase; n=1; Sacc... 49 3e-04
UniRef50_A3ETM0 Cluster: Dihydroorotate dehydrogenase; n=1; Lept... 48 5e-04
UniRef50_P28272 Cluster: Dihydroorotate dehydrogenase; n=72; cel... 48 5e-04
UniRef50_Q7N0H1 Cluster: Similar to dihydroorotate dehydrogenase... 48 7e-04
UniRef50_UPI0000F1DE0E Cluster: PREDICTED: similar to Dihydropyr... 47 0.001
UniRef50_Q7UHA6 Cluster: Dihydroorotate dehydrogenase; n=1; Pire... 47 0.002
UniRef50_A0ADR6 Cluster: Putative hihydroorotate dehydrogenase; ... 47 0.002
UniRef50_P59626 Cluster: Dihydroorotate dehydrogenase A; n=4; La... 47 0.002
UniRef50_Q4AHC8 Cluster: Related to dihydroorotate dehydrogenase... 46 0.002
UniRef50_Q4J443 Cluster: Dihydroorotate dehydrogenase precursor;... 46 0.003
UniRef50_Q6AE78 Cluster: Dihydroorotate dehydrogenase; n=6; Acti... 46 0.003
UniRef50_UPI0000DAE5CB Cluster: hypothetical protein Rgryl_01000... 45 0.005
UniRef50_Q2JDS8 Cluster: Dihydroorotate dehydrogenase; n=3; Fran... 45 0.005
UniRef50_Q7U3U2 Cluster: Dihydroorotate dehydrogenase; n=25; Cya... 44 0.008
UniRef50_Q2IG49 Cluster: Dihydrouridine synthase TIM-barrel prot... 44 0.011
UniRef50_A5UU72 Cluster: Dihydroorotate dehydrogenase; n=4; Chlo... 44 0.011
UniRef50_Q6MRF1 Cluster: Transcription regulator homolog yacF; n... 44 0.014
UniRef50_Q5NRB0 Cluster: Putative uncharacterized protein; n=3; ... 44 0.014
UniRef50_A2F0D1 Cluster: Putative uncharacterized protein; n=1; ... 43 0.019
UniRef50_Q7US31 Cluster: Putative uncharacterized protein; n=1; ... 43 0.025
UniRef50_Q7R9R0 Cluster: Uncharacterized protein family UPF0034,... 42 0.033
UniRef50_Q9WYG8 Cluster: Dihydroorotate dehydrogenase; n=4; Ther... 42 0.033
UniRef50_A7H8H3 Cluster: Dihydroorotate dehydrogenase; n=2; Anae... 42 0.057
UniRef50_Q5PBF6 Cluster: Dihydroorotate dehydrogenase; n=12; Ric... 41 0.075
UniRef50_A6GHV6 Cluster: Dihydrouridine synthase family protein;... 41 0.099
UniRef50_Q44RR4 Cluster: Dihydroorotate dehydrogenase; n=5; Chlo... 40 0.13
UniRef50_Q7S4R9 Cluster: Putative uncharacterized protein NCU057... 40 0.13
UniRef50_Q8YVR2 Cluster: Alr1912 protein; n=9; Bacteria|Rep: Alr... 40 0.17
UniRef50_Q5ZRM0 Cluster: Nitrogen regulation protein; n=4; Legio... 40 0.17
UniRef50_Q2RTR9 Cluster: Dihydrouridine synthase TIM-barrel prot... 40 0.23
UniRef50_Q0B0N8 Cluster: Putative TIM-barrel protein, NifR3 fami... 40 0.23
UniRef50_Q47C62 Cluster: Dihydroorotate dehydrogenase; n=2; Beta... 38 0.53
UniRef50_UPI000023EA9A Cluster: hypothetical protein FG07217.1; ... 38 0.93
UniRef50_A6U9Y2 Cluster: Dihydrouridine synthase DuS; n=2; Sinor... 38 0.93
UniRef50_A6SLQ0 Cluster: Putative uncharacterized protein; n=1; ... 38 0.93
UniRef50_Q4AFB1 Cluster: Putative uncharacterized protein; n=1; ... 37 1.2
UniRef50_A5EVV4 Cluster: Dihydrouridine synthase; n=1; Dicheloba... 37 1.2
UniRef50_Q3AZ67 Cluster: Dihydrouridine synthase TIM-barrel prot... 37 1.6
UniRef50_Q7JP75 Cluster: Cytokinesis defect protein 1, isoform b... 37 1.6
UniRef50_Q22A31 Cluster: TIM-barrel protein, yjbN family; n=1; T... 37 1.6
UniRef50_Q7UBC5 Cluster: tRNA-dihydrouridine synthase A; n=231; ... 37 1.6
UniRef50_Q2W4R2 Cluster: Dihydroorotate dehydrogenase; n=2; Magn... 36 2.1
UniRef50_Q6AQ75 Cluster: Related to dihydroorotate dehydrogenase... 36 2.8
UniRef50_A7SLQ1 Cluster: Predicted protein; n=2; Nematostella ve... 36 2.8
UniRef50_P53759 Cluster: tRNA-dihydrouridine synthase 1; n=11; S... 36 2.8
UniRef50_Q9A7I4 Cluster: Nitrogen regulation protein Nifr3; n=2;... 36 3.7
UniRef50_Q6D5J4 Cluster: Putative bifunctional enzyme including ... 36 3.7
UniRef50_A7HBZ7 Cluster: Homocysteine S-methyltransferase; n=2; ... 36 3.7
UniRef50_Q1GVC1 Cluster: Dihydroorotate dehydrogenase; n=10; Alp... 35 4.9
UniRef50_A1AT39 Cluster: Dihydrouridine synthase, DuS; n=7; Desu... 35 4.9
UniRef50_Q9FH91 Cluster: Gb|AAF51525.1; n=6; Magnoliophyta|Rep: ... 35 4.9
UniRef50_A4S604 Cluster: Predicted protein; n=1; Ostreococcus lu... 35 4.9
UniRef50_A2YPF0 Cluster: Putative uncharacterized protein; n=1; ... 35 4.9
UniRef50_A6C020 Cluster: Putative uncharacterized protein; n=1; ... 35 6.5
UniRef50_A0X038 Cluster: Metallophosphoesterase precursor; n=1; ... 35 6.5
UniRef50_Q8TEK3 Cluster: Histone-lysine N-methyltransferase, H3 ... 35 6.5
UniRef50_Q9Z7D8 Cluster: Predicted oxidoreductase; n=7; Chlamydi... 34 8.6
UniRef50_Q8EYC6 Cluster: Dihydroorotate dehydrogenase; n=4; Lept... 34 8.6
UniRef50_Q30WR3 Cluster: Dihydrouridine synthase family protein;... 34 8.6
UniRef50_Q1IVR5 Cluster: Dihydrouridine synthase TIM-barrel prot... 34 8.6
UniRef50_A5URC7 Cluster: Dihydroorotate dehydrogenase family pro... 34 8.6
UniRef50_A0BLV2 Cluster: Chromosome undetermined scaffold_115, w... 34 8.6
UniRef50_Q7RX85 Cluster: Putative uncharacterized protein NCU000... 34 8.6
UniRef50_A6SMP4 Cluster: Putative uncharacterized protein; n=1; ... 34 8.6
>UniRef50_Q12882 Cluster: Dihydropyrimidine dehydrogenase [NADP+]
precursor; n=70; Eukaryota|Rep: Dihydropyrimidine
dehydrogenase [NADP+] precursor - Homo sapiens (Human)
Length = 1025
Score = 421 bits (1038), Expect = e-116
Identities = 194/272 (71%), Positives = 225/272 (82%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
E GWGFA+TKTFSLDKD+VTNVSPRI+RG TSG YGPGQ SFLNIELISEK AYWCQS
Sbjct: 565 EAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQS 624
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLAC 451
VTELK DFP+ ++IASIMCSYN+ DWT L+KK+E +GADALELNLSCPHGMGE GMGLAC
Sbjct: 625 VTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLAC 684
Query: 452 GQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSI 631
GQDP LV+ I +WVR+A++IPFF KLTPN+TDIVSIA AA EGGA+GV+A NTVSGLM +
Sbjct: 685 GQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGL 744
Query: 632 RADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQ 811
++DGTPWPAVG K TTYGG+SG A RP+ LRAV++I DSAES LQ
Sbjct: 745 KSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQ 804
Query: 812 FIMCGAPVVQICSAVQNQDFTVVDDYITGLKA 907
F+ GA V+Q+CSA+QNQDFTV++DY TGLKA
Sbjct: 805 FLHSGASVLQVCSAIQNQDFTVIEDYCTGLKA 836
>UniRef50_A0CDX9 Cluster: Chromosome undetermined scaffold_17, whole
genome shotgun sequence; n=1; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_17, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 997
Score = 267 bits (654), Expect = 6e-70
Identities = 138/280 (49%), Positives = 168/280 (60%), Gaps = 2/280 (0%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
++GWGFAV KTF LDKD +TNVSPRI + T PG + NIELISEK YW +
Sbjct: 577 QEGWGFAVVKTFVLDKDAITNVSPRIYKSTTDPLKQDPG---YANIELISEKSAKYWLEG 633
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGA-DALELNLSCPHGMGESGMGLA 448
+KK+FPN V+I SIMC + E+DW L++K + G D LELNLSCPHGM E GMG A
Sbjct: 634 SKAIKKEFPNHVLIGSIMCQHIEQDWRELTRKCKNEGQFDMLELNLSCPHGMTELGMGRA 693
Query: 449 CGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMS 628
CG++P +VK I QWV I IP VK+TPN D IA AA EGGA V+ NT LM
Sbjct: 694 CGENPAIVKDICQWVTSEIDIPVIVKITPNYPDSADIAQAAKEGGAKAVTLTNTFPTLMD 753
Query: 629 IRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESAL 808
GTPWPAVG E + TYGG G+ RP+ LR S + + AL
Sbjct: 754 PDPLGTPWPAVGEENNVTYGGGCGSMLRPIALRKTSEVAKAIPDIAIFGSGGIIQGDHAL 813
Query: 809 QFIMCGAPVVQICSAVQNQDF-TVVDDYITGLKAPVVHSF 925
F+ GA QICSAVQ+QDF TV+ D T +A + S+
Sbjct: 814 SFLRYGASAFQICSAVQDQDFATVLYDLKTSFQAHLYASY 853
>UniRef50_A2ELU8 Cluster: Dihydroorotate dehydrogenase family protein;
n=3; Trichomonas vaginalis G3|Rep: Dihydroorotate
dehydrogenase family protein - Trichomonas vaginalis G3
Length = 811
Score = 235 bits (576), Expect = 2e-60
Identities = 129/280 (46%), Positives = 174/280 (62%), Gaps = 11/280 (3%)
Frame = +2
Query: 98 GWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVT 277
G G+AVTKT KD++ RIV+ + EN GP GSF NI +++E E YW ++
Sbjct: 398 GMGWAVTKTILPTKDVIRENDFRIVK---ADENPGPS-GSFCNICMMTEHTEEYWLDTIK 453
Query: 278 ELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCP---HGMG------- 427
+LK +FP++V++ASI S ++E W L K AAGADALELNLSCP HG G
Sbjct: 454 KLKAEFPDRVLVASIATSDSKERWQNLVKNVIAAGADALELNLSCPNEVHGEGGCKGGFD 513
Query: 428 -ESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAI 604
E+ +G+A G P+ VK ISQ+V++A +PFFVKLTPNITD + IA AA EGGA GV+ I
Sbjct: 514 TENKIGMALGTHPISVKRISQYVKEATTVPFFVKLTPNITDPIDIAQAALEGGADGVAMI 573
Query: 605 NTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXX 784
NTVSG+ DGTP P VG+EK+ GGLSG+ RP+ LR +S + N+
Sbjct: 574 NTVSGIAKFWPDGTPLPQVGKEKYVLSGGLSGDQVRPIALRQISRVHNKFPEMPILGIGG 633
Query: 785 XDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGLK 904
S +ALQ + G+ V Q+CSA+Q + +V + GL+
Sbjct: 634 IGSGYTALQHLYAGSSVFQMCSAIQRYSYDIVREVNAGLQ 673
>UniRef50_UPI000049A38F Cluster: dihydropyrimidine dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: dihydropyrimidine
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 1103
Score = 228 bits (558), Expect = 3e-58
Identities = 127/288 (44%), Positives = 175/288 (60%), Gaps = 17/288 (5%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
+ G+GFA+TKT+ L+KD+ N RIV+ S E+ S+ NI +ISE YW +S
Sbjct: 470 QAGFGFALTKTYPLEKDIQKNNHIRIVKVYDSQEST-----SYNNIVMISEHSHHYWLES 524
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCP---HGM-GESG- 436
+ +LK +FPNKV+IASIMC N +DW LL+K +E AGADALELN SCP HG G G
Sbjct: 525 IKKLKAEFPNKVVIASIMCMDNADDWHLLAKLSEEAGADALELNFSCPNECHGNDGNEGG 584
Query: 437 ----------MGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGA 586
M +A G P ++ +++V +++ IP + KLTPN+ +I +A AA GGA
Sbjct: 585 CEGGFKSHNAMAMAIGVSPAAIERCTRYVVESVHIPVYPKLTPNVGNIEELAAAAMRGGA 644
Query: 587 SGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAI--GNRXXX 760
SGVS INTV G+ I G PWP VG E++T GGLSG+ RP+ +R ++ + N
Sbjct: 645 SGVSTINTVFGISEITLSGHPWPQVGVERNTISGGLSGDLVRPIAIRQIAQVLRHNENVR 704
Query: 761 XXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGLK 904
SAE+A+Q I GA VVQ+CS+VQ + +VD+ I+G K
Sbjct: 705 GHLLGIGGVRSAETAMQLIYTGASVVQMCSSVQKWSYDIVDEIISGTK 752
>UniRef50_Q23YG3 Cluster: Dihydroorotate dehydrogenase family protein;
n=1; Tetrahymena thermophila SB210|Rep: Dihydroorotate
dehydrogenase family protein - Tetrahymena thermophila
SB210
Length = 1080
Score = 221 bits (540), Expect = 4e-56
Identities = 117/271 (43%), Positives = 156/271 (57%), Gaps = 1/271 (0%)
Frame = +2
Query: 98 GWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVT 277
G+ FAV KT LDKD V NVSPRI + + S+ NIEL+SEK YW +
Sbjct: 656 GYDFAVVKTAVLDKDTVFNVSPRIFKVPDPLRQ----ECSYGNIELVSEKSLKYWVEGAK 711
Query: 278 ELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQ 457
++KKD+PNKV+I S+M +YN++DW + + + A D +ELNLSCPHGM E GMG ACG+
Sbjct: 712 QIKKDYPNKVLIGSLMAAYNQQDWIDIMHQVKDAPFDMIELNLSCPHGMNEKGMGRACGE 771
Query: 458 DPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRA 637
DP +V+ I+ WV KIP VK+TPN +A AAYEGGA V+ NT+ GL+
Sbjct: 772 DPDIVRDITSWVTSQTKIPIIVKITPNYGQAEILAKAAYEGGAKAVTLTNTMPGLVDPYP 831
Query: 638 DGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFI 817
DG + VG EK+ GG +G+ RP +R + S + + ++
Sbjct: 832 DGESFNGVGVEKNVAPGGSTGSILRPFAMRKCVDVAKFVPEIDIFASGGIISGDHGINYL 891
Query: 818 MCGAPVVQICSAVQNQD-FTVVDDYITGLKA 907
GA +QICSAVQN D TV D T L+A
Sbjct: 892 HYGAKALQICSAVQNLDAATVFYDLKTSLQA 922
>UniRef50_Q39PB0 Cluster: Dihydroorotate dehydrogenase 1; n=81;
Bacteria|Rep: Dihydroorotate dehydrogenase 1 -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 438
Score = 182 bits (444), Expect = 2e-44
Identities = 104/273 (38%), Positives = 150/273 (54%), Gaps = 3/273 (1%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
E GWG V KT LD +V NVS R +G+ NIELI+++ +
Sbjct: 36 EAGWGGVVWKTLGLDPHVV-NVSSRYGAVQWNGQRIA----GLNNIELITDRPLDVNLRE 90
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLAC 451
+ ++K+D+P++ +I S+M NE DW + E GADA+ELN CPHGM E GMG A
Sbjct: 91 IAQVKRDWPDRALIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGAAV 150
Query: 452 GQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSI 631
GQ P V+ +++WV++ K+P VKLTPNI+DI + AAY+GGA GVS INT++ ++++
Sbjct: 151 GQVPEYVEMVTRWVKEGTKLPCLVKLTPNISDIRMGSRAAYKGGADGVSLINTINSIVAV 210
Query: 632 RADG-TPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGN--RXXXXXXXXXXXXDSAES 802
D P P V + T+GG G A +P+ L V+ I S
Sbjct: 211 DLDHMAPMPMV--DGKGTHGGYCGPAVKPIALNMVAEIARDPETPNLPISGIGGISSWRD 268
Query: 803 ALQFIMCGAPVVQICSAVQNQDFTVVDDYITGL 901
A +F++ GA VQ+C+A + F +V D GL
Sbjct: 269 AAEFMVLGAGSVQVCTAAMHYGFRIVSDLADGL 301
>UniRef50_Q9LVI9 Cluster: Senescencs-related protein; dihydroorotate
dehydrogenase-like protein; n=12; cellular
organisms|Rep: Senescencs-related protein;
dihydroorotate dehydrogenase-like protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 426
Score = 169 bits (411), Expect = 2e-40
Identities = 100/280 (35%), Positives = 144/280 (51%), Gaps = 9/280 (3%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFL---NIELISEKCEAYW 262
++GWG + KT SLD V NV+PR R + +G N G + + NIELIS++
Sbjct: 84 DEGWGAVIAKTVSLDASKVINVTPRYAR-LRTGSN-GSAKTDVIGWQNIELISDRPLETM 141
Query: 263 CQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMG 442
+ LKK++P++++IAS+M YN+ W L + E G DALE+N SCPHGM E MG
Sbjct: 142 LKEFERLKKEYPDRILIASVMEEYNKTAWEELIDRVEQTGVDALEINFSCPHGMPERRMG 201
Query: 443 LACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGL 622
A GQD L+ + W+ +P + K+TPNITDI A + + G G++AINT+ +
Sbjct: 202 AAVGQDCALLDEVCGWINAKATVPVWAKMTPNITDITEPARVSLKSGCEGIAAINTIMSV 261
Query: 623 MSIRADG-TPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNR-----XXXXXXXXXXX 784
M I P P V E ++T GG S A RP+ L V I
Sbjct: 262 MGIDMKTLRPEPCV--EGYSTPGGYSYKAVRPIALAKVMNIAKMMKSEFSEDRSLSGIGG 319
Query: 785 XDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGLK 904
++ A +FI+ G+ VQ+C+ V + V LK
Sbjct: 320 VETGYDAAEFILLGSNTVQVCTGVMMHGYGHVKTLCAELK 359
>UniRef50_Q099I4 Cluster: Dihydropyrimidine dehydrogenase; n=1;
Stigmatella aurantiaca DW4/3-1|Rep: Dihydropyrimidine
dehydrogenase - Stigmatella aurantiaca DW4/3-1
Length = 462
Score = 161 bits (391), Expect = 4e-38
Identities = 99/274 (36%), Positives = 146/274 (53%), Gaps = 4/274 (1%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLN-IELISEKCEAYWCQ 268
+ GWG AV KT + + NV+ R G +YG + LN IELI+++ +
Sbjct: 36 DAGWGGAVWKTLG---NPIVNVTSRF-----GGIDYGNTRLMGLNNIELITDRPLEVNFR 87
Query: 269 SVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLA 448
+ E+KK FP ++AS+M EE W + +++E AGAD LELN CPHGM E GMG A
Sbjct: 88 EMLEVKKRFPKHTLVASLMVETKEE-WREIIQRSEDAGADLLELNFGCPHGMCERGMGSA 146
Query: 449 CGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMS 628
G +P +++ I++W + ++P VKLTPN+ DI+ AA G +S INTV +M
Sbjct: 147 VGAEPKVLEEIARWAVEFARVPVIVKLTPNVGDILEPGEAAVRAGVPALSLINTVKSIMG 206
Query: 629 IRADG-TPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGN--RXXXXXXXXXXXXDSAE 799
+ D P P VG +T GG G A +P+ L +S + + +
Sbjct: 207 VDLDRMVPLPRVG--DASTNGGYCGPAVKPIALHLLSQLARHPQCGRLAISGIGGISNWR 264
Query: 800 SALQFIMCGAPVVQICSAVQNQDFTVVDDYITGL 901
A +FI GA VQ+C+AV + F +V+D + GL
Sbjct: 265 DAAEFIALGATSVQVCTAVMHHGFRIVEDMLEGL 298
>UniRef50_A0W5K9 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Geobacter lovleyi SZ|Rep: Dihydroorotate
dehydrogenase family protein - Geobacter lovleyi SZ
Length = 398
Score = 147 bits (357), Expect = 6e-34
Identities = 99/268 (36%), Positives = 138/268 (51%), Gaps = 4/268 (1%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
E GWG AV KT L ++ V N+ R + +G F N+EL+SE+ W ++
Sbjct: 37 EAGWGGAVIKT--LIREPVHNLPNRF-----AAIRHGNRITGFENLELLSEQAPDEWYRA 89
Query: 272 VTELKKDFPNKVIIASIMCSYNEED-WTLLSKKAEAAGADALELNLSCPHGMGESGMGLA 448
+ +K DFP+ II SIM + N D W L+ + AGAD LELN SCPHG E G G A
Sbjct: 90 IRCIKADFPDCPIIGSIMGAANSPDEWHSLALGCQDAGADLLELNFSCPHGYPERGRGAA 149
Query: 449 CGQDPVLVKGISQWVR--KAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGL 622
GQ+P I++WV K I IP KLT + +I +IA GA G AINT+
Sbjct: 150 IGQNPDYAAQITRWVTDCKEITIPVIPKLTAAVANIQNIAEELALAGAHGFCAINTIPSF 209
Query: 623 MSIRADG-TPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAE 799
P P +G + T+YGG SG +P+ LRAVS + + +
Sbjct: 210 FGFDLRTLRPKPDIGGK--TSYGGYSGPGIKPIALRAVSELCQSPGLPVMASGGIANGFD 267
Query: 800 SALQFIMCGAPVVQICSAVQNQDFTVVD 883
A++F++ GAPVVQ+ + V F ++D
Sbjct: 268 -AVEFMLLGAPVVQMATEVMLHGFGIID 294
>UniRef50_A5VL42 Cluster: Dihydroorotate dehydrogenase family
protein; n=2; Lactobacillus reuteri|Rep: Dihydroorotate
dehydrogenase family protein - Lactobacillus reuteri
F275
Length = 432
Score = 142 bits (344), Expect = 2e-32
Identities = 92/275 (33%), Positives = 137/275 (49%), Gaps = 5/275 (1%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
+ GWG V KT S + VSPR ++ +F N+E +SE
Sbjct: 38 DAGWGGIVYKTLSPTHFKIDEVSPRFDELAKEDMHFV----AFKNMEQLSEHPLEQDLAD 93
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLAC 451
+ LK+++PNKV+IASIM EDWT L+K GAD +ELN SCP M MG
Sbjct: 94 MRRLKEEYPNKVLIASIM-GETLEDWTNLAKLVTETGADMIELNFSCPQ-MTSHTMGSDV 151
Query: 452 GQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSI 631
G +P L K + V++ +P K+TPNIT +V + A EGGA G SAINTV ++ +
Sbjct: 152 GTNPELCKKNCEAVKRGTSLPVLAKMTPNITTMVPVVKACLEGGADGFSAINTVKSIVDV 211
Query: 632 ---RADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNR--XXXXXXXXXXXXDSA 796
+ G P + ++ GLSG A +P+ LR + + + ++
Sbjct: 212 DLKKKVGLP----NIDGKSSVSGLSGKAVKPIALRFLQQLRSAAGLEQLPISGIGGIETW 267
Query: 797 ESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGL 901
E A +FI+ GA +Q+ +A+ + ++DD GL
Sbjct: 268 EDAAEFILLGATTLQVTTAIMEYGYRIIDDLTNGL 302
>UniRef50_P25889 Cluster: Uncharacterized protein yeiA; n=22;
Bacteria|Rep: Uncharacterized protein yeiA - Escherichia
coli (strain K12)
Length = 411
Score = 138 bits (334), Expect = 4e-31
Identities = 87/272 (31%), Positives = 137/272 (50%), Gaps = 2/272 (0%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
+ GWG V KT + VSPR V + F N+E I+E +
Sbjct: 38 DTGWGGVVFKTIGFF--IANEVSPRFDHLVKEDTGFI----GFKNMEQIAEHPLEENLAA 91
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLAC 451
+ LK+D+P+KV+IASIM NE+ W L++ + AGAD +E N SCP M MG
Sbjct: 92 LRRLKEDYPDKVLIASIM-GENEQQWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDV 149
Query: 452 GQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSI 631
GQ P LV+ + V++ +P K+TPNI D+ +A+AA GGA G++AINTV + +I
Sbjct: 150 GQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNI 209
Query: 632 RADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGN--RXXXXXXXXXXXXDSAESA 805
+ + K ++ G SG A +P+ LR + + ++ E A
Sbjct: 210 DLNQKIGMPIVNGK-SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDA 268
Query: 806 LQFIMCGAPVVQICSAVQNQDFTVVDDYITGL 901
+F++ GA +Q+ + + + +V+D +GL
Sbjct: 269 AEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300
>UniRef50_Q972L2 Cluster: 350aa long hypothetical dihydroorotate
dehydrogenase; n=1; Sulfolobus tokodaii|Rep: 350aa long
hypothetical dihydroorotate dehydrogenase - Sulfolobus
tokodaii
Length = 350
Score = 132 bits (318), Expect = 3e-29
Identities = 92/266 (34%), Positives = 134/266 (50%), Gaps = 2/266 (0%)
Frame = +2
Query: 98 GWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVT 277
GWG V KT D + +V P + E +F N+ELI+E W + +
Sbjct: 38 GWGGVVVKTIG-DSIVRKSVRPMYATIRRNREII-----AFENLELITEDPLEVWDKYLR 91
Query: 278 ELKKDFPNKV-IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACG 454
+K + II SIM + +W L++ AE GAD LELN CPHG E G G
Sbjct: 92 VIKSEIGKSAPIIVSIMGGPDYSEWIRLARWAEDRGADMLELNFGCPHGEPEKRTGAFIG 151
Query: 455 QDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIR 634
Q LV+ ++ V ++ IP KLTPNITDI A AA GA V+AINTV+G++++
Sbjct: 152 QHADLVQEYTKEVVSSVGIPVIAKLTPNITDIRETAKAAENAGAKAVTAINTVNGVIAVD 211
Query: 635 AD-GTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQ 811
+ P P + ++ YGG+SG A +P+GL AVS I D + A++
Sbjct: 212 IERAQPLPDI--NGYSGYGGISGPAVKPIGLAAVSKIYTSTSLQISGVGGIFDWRD-AVE 268
Query: 812 FIMCGAPVVQICSAVQNQDFTVVDDY 889
+IM GA VQ + + F ++++
Sbjct: 269 YIMMGATTVQSVTYTILKGFEFINEW 294
>UniRef50_Q1F0W8 Cluster: Dihydroorotate dehydrogenase 1; n=1;
Clostridium oremlandii OhILAs|Rep: Dihydroorotate
dehydrogenase 1 - Clostridium oremlandii OhILAs
Length = 372
Score = 113 bits (272), Expect = 1e-23
Identities = 86/279 (30%), Positives = 138/279 (49%), Gaps = 1/279 (0%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQS 271
E G G VTKT + ++ NV PR+V+G + NIEL S W
Sbjct: 35 EAGAGAVVTKTIA--NEIRPNVRPRLVKG----------REGLHNIELYSGFTLEEWENE 82
Query: 272 VTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLAC 451
+ K V+IA+I+ + + +++K E GADA+EL +SCPHG G G+
Sbjct: 83 IAYAK--IHGAVVIANIL-GHTSSEIAYIAQKVEQFGADAVELGVSCPHGEGLEGVI--- 136
Query: 452 GQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSI 631
+P + ++ V IKIP VKL+ N ++V +A AA + GAS +S I+TV + +
Sbjct: 137 -SEPSKLYEFTKAVVDRIKIPVMVKLSSNTVNVVKLARAAEKAGASAISGIDTVRSIAGV 195
Query: 632 RADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQ 811
+ GR T+GG SG+A RP+GL A+++I + + E L+
Sbjct: 196 DIE------KGRVLLPTFGGYSGDAIRPIGLAAIASIA-QATSIPICGIGGITNYEHILE 248
Query: 812 FIMCGAPVVQICSAVQNQDFTVVDDYITGLKAPVV-HSF 925
++M GA VQ+C+++ + + + GL + HS+
Sbjct: 249 YMMLGASTVQVCTSIILNGYEHISTLLDGLNGWMAQHSY 287
>UniRef50_Q1G992 Cluster: Dihydroorotate dehydrogenase; n=3;
Lactobacillus delbrueckii|Rep: Dihydroorotate
dehydrogenase - Lactobacillus delbrueckii subsp.
bulgaricus (strain ATCC 11842 / DSM20081)
Length = 309
Score = 108 bits (260), Expect = 3e-22
Identities = 80/239 (33%), Positives = 128/239 (53%), Gaps = 1/239 (0%)
Frame = +2
Query: 227 IELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNL 406
+ L + E + + L++ P+ I+AS+ + ED+ +++ AA DALELNL
Sbjct: 73 VGLTNPGAEVVASEKIPALREKHPDLPILASVG-GESVEDYVEVAEILAAAKPDALELNL 131
Query: 407 SCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGA 586
SCP+ + E GM G P +++ I++ V++ + +P +VKLTPN+T IV IA AA GGA
Sbjct: 132 SCPN-VSEGGMTF--GIVPEMLEKITRLVKEKVDLPVYVKLTPNVTSIVEIAQAAEGGGA 188
Query: 587 SGVSAINTVSGLMSIRAD-GTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXX 763
G++ INT L+ + D T P +G + +GGL G A +P+ +R V+ + +
Sbjct: 189 DGLTLINT---LLVLHLDLKTRRPVLGND----FGGLYGQAVKPVAVRMVAQV-KQATSL 240
Query: 764 XXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGLKAPVVHSFXGLTD 940
+S E A +FI+ GA VQI ++ D + I GL P V + G +D
Sbjct: 241 PIIGVGGINSPEDAAEFILAGASAVQI-GSMSFYDKLAIKHVIDGL--PAVLAGMGASD 296
>UniRef50_Q979G6 Cluster: Dihydroorotate dehydrogenase; n=4;
Thermoplasmatales|Rep: Dihydroorotate dehydrogenase -
Thermoplasma volcanium
Length = 301
Score = 108 bits (259), Expect = 4e-22
Identities = 69/183 (37%), Positives = 99/183 (54%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
II S+ +YN E++T LS K E G DA+ELNLSCPH G GL G DP LV+ I
Sbjct: 95 IIGSVF-AYNAEEFTKLSVKMEEYGVDAIELNLSCPH---VKGFGLEVGSDPDLVEDIVN 150
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGR 667
++ +K+P F KL+PN+++I+ IA AA + A INTV + +P
Sbjct: 151 EIKSKVKVPVFAKLSPNVSNIIEIAKAAEK--ADAYVLINTVKAMAIDIYSRSP------ 202
Query: 668 EKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQIC 847
YGGLSG A +P+G+R V + + + + A+++IM GA VQI
Sbjct: 203 VLSNLYGGLSGPAIKPVGIRYVYEV-KKETGKEIIGVGGISNYKDAIEYIMAGASAVQIG 261
Query: 848 SAV 856
+A+
Sbjct: 262 TAL 264
>UniRef50_Q8PW56 Cluster: Dihydroorotate dehydrogenase; n=14;
Euryarchaeota|Rep: Dihydroorotate dehydrogenase -
Methanosarcina mazei (Methanosarcina frisia)
Length = 314
Score = 105 bits (252), Expect = 3e-21
Identities = 71/196 (36%), Positives = 103/196 (52%)
Frame = +2
Query: 278 ELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQ 457
E K+ + +IASI E + +++ A DA ELN+SCPH G G A G
Sbjct: 96 EFAKENSDAPVIASIFGGTPSE-FAEVAEGLLPAKPDAFELNVSCPHA---EGYGAAIGS 151
Query: 458 DPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRA 637
+P LV+ ++ V+ + +P +VKLTPN+ DI I AA GGA V AINTV G M+I
Sbjct: 152 NPCLVEAVTAAVKDVVNVPVWVKLTPNVADITCIGNAAESGGADAVVAINTVKG-MAIDI 210
Query: 638 DGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFI 817
+ + +P +G GGLSG A +P+ ++ V + S E A++ I
Sbjct: 211 E-SGYPVLGNRS----GGLSGKAVKPVAVKCVYDLFT-ALEIPVIGVGGVSSWEDAVEMI 264
Query: 818 MCGAPVVQICSAVQNQ 865
M GA VQ+ SAV ++
Sbjct: 265 MAGAAAVQVGSAVYDR 280
>UniRef50_Q67PZ8 Cluster: Dihydroorotate dehydrogenase catalytic
subunit; n=6; Bacteria|Rep: Dihydroorotate dehydrogenase
catalytic subunit - Symbiobacterium thermophilum
Length = 306
Score = 99 bits (238), Expect = 2e-19
Identities = 61/171 (35%), Positives = 90/171 (52%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFF 520
E++ ++++ E G A+ELN+SCP+ + E GM A G P ++ VRKA +P
Sbjct: 110 EEYVAVARRLEGTGVAAVELNISCPN-VKEGGM--AFGTTPGSAAAVTAAVRKATTLPLI 166
Query: 521 VKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSG 700
VKL+PN+ D+V+IA A + GA G+S INT+ G+ G P +GGLSG
Sbjct: 167 VKLSPNVADVVAIARAVEDAGADGLSVINTLQGMSIDIRRGRP------HLGNVFGGLSG 220
Query: 701 NATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
A +P+ LR V + S E A +F+M GA VQ+ +A
Sbjct: 221 PAIKPVALRMVWQVAGAVKVPVIGVGGIM-SGEDAAEFLMAGASAVQVGTA 270
>UniRef50_Q47741 Cluster: Dihydroorotate dehydrogenase B, catalytic
subunit; n=104; Bacteria|Rep: Dihydroorotate
dehydrogenase B, catalytic subunit - Enterococcus
faecalis (Streptococcus faecalis)
Length = 312
Score = 98.7 bits (235), Expect = 4e-19
Identities = 77/256 (30%), Positives = 125/256 (48%), Gaps = 4/256 (1%)
Frame = +2
Query: 98 GWGFAVTKTFSLDK---DMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQ 268
G+G + LD+ M+ +P+ G + G I L + E +
Sbjct: 27 GFGEEYANYYDLDQLGSIMIKATTPQARYGNPTPRVAETPSGMLNAIGLQNPGLEVVMQE 86
Query: 269 SVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLA 448
+ +L+K +PN IIA++ + E+ + +K +A A+ELN+SCP+ + G G+A
Sbjct: 87 KLPKLEK-YPNLPIIANVAGACEEDYVAVCAKIGQAPNVKAIELNISCPNV--KHG-GIA 142
Query: 449 CGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMS 628
G DP + ++Q V+K +P +VKL+PN+TDIV IA A GGA G S INT L+
Sbjct: 143 FGTDPEVAFQLTQAVKKVASVPIYVKLSPNVTDIVPIAQAIEAGGADGFSMINT---LLG 199
Query: 629 IRAD-GTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESA 805
+R D T P + + GGLSG A +P+ +R + + + + +
Sbjct: 200 MRIDLKTRKPILANQT----GGLSGPAIKPVAIRLIRQVAS-VSQLPIIGMGGVQTVDDV 254
Query: 806 LQFIMCGAPVVQICSA 853
L+ M GA V + +A
Sbjct: 255 LEMFMAGASAVGVGTA 270
>UniRef50_Q9V0Y6 Cluster: Dihydroorotate dehydrogenase; n=8;
Euryarchaeota|Rep: Dihydroorotate dehydrogenase -
Pyrococcus abyssi
Length = 303
Score = 97.5 bits (232), Expect = 8e-19
Identities = 72/215 (33%), Positives = 107/215 (49%), Gaps = 1/215 (0%)
Frame = +2
Query: 260 WCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGM 439
W + E +K+ + +I SI EE L K E A DA ELNLSCPH G
Sbjct: 80 WEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVA--DAFELNLSCPHA---KGY 134
Query: 440 GLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSG 619
G+ GQ P V + + V+ P KLTPN++DI + +AA + GA GVSAINTV
Sbjct: 135 GMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGADGVSAINTVKA 194
Query: 620 L-MSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSA 796
+ + I A P + + +GG SG +P+ LRAV + + +
Sbjct: 195 IAIDIYAKR---PILSNK----FGGYSGPGVKPIALRAVYDLAS-SLDIPVIGIGGITTW 246
Query: 797 ESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGL 901
+ A++F++ GA +QI +AV + F+V + G+
Sbjct: 247 QDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGI 281
>UniRef50_Q8G660 Cluster: Dihydroorotate dehydrogenase; n=4;
Bifidobacterium|Rep: Dihydroorotate dehydrogenase -
Bifidobacterium longum
Length = 323
Score = 96.7 bits (230), Expect = 1e-18
Identities = 61/181 (33%), Positives = 91/181 (50%)
Frame = +2
Query: 311 IASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQW 490
+ S + + ++D+ + +K + AD LE+N+SCP+ S G++ G DPV + +
Sbjct: 116 VISNVAGHCDDDYAAVVEKLADSDADMLEINVSCPN---VSAGGMSVGTDPVALANLMDR 172
Query: 491 VRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGRE 670
+R P VKLTPN+TDI A AA E GA +S INT+ G+ G P A
Sbjct: 173 LRPMTDKPMIVKLTPNVTDITVPARAAVEHGADALSMINTLKGMRINIRTGKPIIA---- 228
Query: 671 KHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICS 850
GG+SG A P+GL AV + DS E AL+++ GA V++ +
Sbjct: 229 --NVTGGVSGPAVLPVGLAAVYRVRTALPEIPIIGLGGIDSGEKALEYLYAGANAVEVGA 286
Query: 851 A 853
A
Sbjct: 287 A 287
>UniRef50_Q3AC05 Cluster: Dihydroorotate dehydrogenase, catalytic
subunit; n=1; Carboxydothermus hydrogenoformans
Z-2901|Rep: Dihydroorotate dehydrogenase, catalytic
subunit - Carboxydothermus hydrogenoformans (strain
Z-2901 / DSM 6008)
Length = 307
Score = 89.8 bits (213), Expect = 2e-16
Identities = 69/200 (34%), Positives = 105/200 (52%), Gaps = 2/200 (1%)
Frame = +2
Query: 257 YWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGA-DALELNLSCPHGMGES 433
Y+C+ + KD N ++I +I + E++ L+++A+ ALELN+SCP+ S
Sbjct: 79 YFCEKILPQIKDL-NDILILNI-AGESVEEFQYLAREAQRFDEIKALELNVSCPN---VS 133
Query: 434 GMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTV 613
G+A G D +K I VRK VKLTPN+TDI A AA GA ++ INT
Sbjct: 134 KGGIAFGTDLEALKQIVSSVRKIYSKTLIVKLTPNVTDITVYAKAAENAGADALTLINTF 193
Query: 614 SGL-MSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXD 790
+G+ + +++ P +G KH GG+SG A RPM ++ V + D
Sbjct: 194 TGMVIDVKSKK---PILG-NKH---GGVSGPAIRPMAVKMVYDC-FKAVSIPIIGVGGID 245
Query: 791 SAESALQFIMCGAPVVQICS 850
S E+AL+F + GA +Q+ S
Sbjct: 246 SKEAALEFFLAGATAIQVGS 265
>UniRef50_Q1Q4L5 Cluster: Similar to dihydroorotate oxidase
(Dihydroorotate dehydrogenase B) catalytic subunit; n=1;
Candidatus Kuenenia stuttgartiensis|Rep: Similar to
dihydroorotate oxidase (Dihydroorotate dehydrogenase B)
catalytic subunit - Candidatus Kuenenia stuttgartiensis
Length = 306
Score = 89.0 bits (211), Expect = 3e-16
Identities = 61/200 (30%), Positives = 103/200 (51%), Gaps = 1/200 (0%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQD-PVLVKGIS 484
+IASI+ + + D+ +++ A+G A+E+ LSCPH G GL GQ P I+
Sbjct: 97 VIASIIGTCTD-DFIEVAEGLSASGFSAIEIPLSCPH---TPGFGLLSGQGTPKATYEIT 152
Query: 485 QWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVG 664
VR+ +P FVK++PN+ +I SIA AA + GA+G++A+N++ M I + P +G
Sbjct: 153 YAVRRKTNVPIFVKISPNVPEITSIAKAAEDAGANGITAVNSMGPGMVINIESKK-PVLG 211
Query: 665 REKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQI 844
+ GG++G+A RP+ +R V + + + A++ +M GA V I
Sbjct: 212 FK----VGGVTGDALRPIAVRCVYDV-YQAVKIPIIGVGGISTGRHAIEMMMAGASAVGI 266
Query: 845 CSAVQNQDFTVVDDYITGLK 904
+ V + V +K
Sbjct: 267 GTGVYTRGINVFSKVCAEMK 286
>UniRef50_Q73P17 Cluster: Dihydroorotate
dehydrogenase/oxidoreductase, FAD-binding; n=1;
Treponema denticola|Rep: Dihydroorotate
dehydrogenase/oxidoreductase, FAD-binding - Treponema
denticola
Length = 591
Score = 87.0 bits (206), Expect = 1e-15
Identities = 58/163 (35%), Positives = 83/163 (50%), Gaps = 4/163 (2%)
Frame = +2
Query: 266 QSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGL 445
+ + EL+ + I+ + + N ED+ L K E AD ELN SCPH +G G
Sbjct: 95 KELKELRSSWKTDSILNVSLSASNPEDFISLLKGFEEL-ADCFELNFSCPHA--SAGFGA 151
Query: 446 ACGQDPVLVKGISQWVRKAIK---IPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVS 616
+ G DP + + ++KA+ +P FVKLTPN+ DI +IA A E GA G++AINTV
Sbjct: 152 SIGCDPAIAAEYVKIIKKALPDCAVPIFVKLTPNVEDIGAIASAVIEAGADGITAINTVG 211
Query: 617 GLMSIRA-DGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAI 742
+ I G P + + K GG+SG P L + I
Sbjct: 212 PKVYIEPHSGKP---ILQNKLGGKGGMSGAWVFPRALECIGQI 251
>UniRef50_A7DP74 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Dihydroorotate dehydrogenase family protein -
Candidatus Nitrosopumilus maritimus SCM1
Length = 303
Score = 86.2 bits (204), Expect = 2e-15
Identities = 64/198 (32%), Positives = 98/198 (49%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
II S++ S ED+ + K+ E A ELNLSCPH + +GL G DP LVK I
Sbjct: 95 IIVSLVGSI-PEDFEKMIKQFENCKVTAYELNLSCPH---VAKVGLEVGDDPELVKKIVT 150
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGR 667
V+ + +P K+ T ++ A E G ++AINTV M+I + T P +
Sbjct: 151 TVKNSTNVPVIAKVGLGTTHYLNTVGTAIESGIDAITAINTVRS-MAIDVE-TQRPILSN 208
Query: 668 EKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQIC 847
+ +GGLSG +P+ LR V I ++ + E A++F + GA VQ+
Sbjct: 209 K----FGGLSGTPIKPIALRCVYEISSK-YDIPIIGCGGISTWEDAVEFFLAGASSVQLG 263
Query: 848 SAVQNQDFTVVDDYITGL 901
SA+ + V ++ TG+
Sbjct: 264 SAIGDNWIDVFNEINTGI 281
>UniRef50_Q8TXU6 Cluster: Dihydroorotate dehydrogenase; n=1;
Methanopyrus kandleri|Rep: Dihydroorotate dehydrogenase
- Methanopyrus kandleri
Length = 318
Score = 85.8 bits (203), Expect = 3e-15
Identities = 58/173 (33%), Positives = 87/173 (50%), Gaps = 4/173 (2%)
Frame = +2
Query: 365 KAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNI- 541
+A + AD LELN+SCPH G G G DP V I++ +A P VKLTPN+
Sbjct: 113 RAFSGVADGLELNVSCPHA--GKGYGAELGSDPEAVAEITEAAVRAFDGPVSVKLTPNVD 170
Query: 542 -TDIVSIAVAAYEGGASGVSAINTVSGLMSIRAD-GTPWPAVGREKHTTYGGLSGNATRP 715
++ +A AA + GA ++A+NT+ +R D T P +G GGLSG A +P
Sbjct: 171 RETLLEVAAAAIDAGAEALTAVNTLG--PGLRIDLRTASPVLG----AGVGGLSGPALKP 224
Query: 716 MGLRAVSAIG-NRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDF 871
+ LR V+ + + E ++F+ GA VQ+ +A + +DF
Sbjct: 225 IALRVVADLALEFGEEVEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDF 277
>UniRef50_A6G037 Cluster: Dihydroorotate dehydrogenase 1; n=1;
Plesiocystis pacifica SIR-1|Rep: Dihydroorotate
dehydrogenase 1 - Plesiocystis pacifica SIR-1
Length = 334
Score = 84.2 bits (199), Expect = 8e-15
Identities = 53/154 (34%), Positives = 84/154 (54%), Gaps = 1/154 (0%)
Frame = +2
Query: 386 DALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAV 565
D LE+N+SCP+ + G G+ G P + +++ +A ++P VKLTPN++DIV++A
Sbjct: 138 DVLEMNISCPNI--KKG-GIEFGTVPEVAHRLTKACVEASEVPIVVKLTPNVSDIVAMAQ 194
Query: 566 AAYEGGASGVSAINTVSGL-MSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAI 742
A E GA GVS INT++ + + +R+ + TTYGGLSG A +P+ LR V +
Sbjct: 195 AVKEAGAIGVSLINTITAMAIDVRSRRS-------RIATTYGGLSGPAIKPVALRMVHQV 247
Query: 743 GNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQI 844
+ E L++ + GA VQ+
Sbjct: 248 AKALPGFPICGMGGILTGEDVLEYFIAGAHCVQL 281
>UniRef50_Q9K9W1 Cluster: Dihydroorotate dehydrogenase; n=1;
Bacillus halodurans|Rep: Dihydroorotate dehydrogenase -
Bacillus halodurans
Length = 305
Score = 84.2 bits (199), Expect = 8e-15
Identities = 54/155 (34%), Positives = 85/155 (54%)
Frame = +2
Query: 389 ALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVA 568
ALELN+SCP+ + G G+A G P + ++Q V++ +P +VKL+PN++DIV +A A
Sbjct: 123 ALELNISCPNV--KEG-GIAFGTVPDVAAQLTQEVKRVSTVPVYVKLSPNVSDIVEMAQA 179
Query: 569 AYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGN 748
GA G+S INT+ G+ TP A G GGLSG A +P+ +R + + +
Sbjct: 180 VERAGADGLSMINTLLGMRLDLKRRTPILANGT------GGLSGPAIKPVAIRMIYQV-S 232
Query: 749 RXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+ SA+ L+F++ GA V + +A
Sbjct: 233 QAVSIPIIGMGGIQSADDVLEFMLAGADAVAVGTA 267
>UniRef50_A4A2Y8 Cluster: Dihydroorotate dehydrogenase; n=3;
Planctomycetaceae|Rep: Dihydroorotate dehydrogenase -
Blastopirellula marina DSM 3645
Length = 317
Score = 83.8 bits (198), Expect = 1e-14
Identities = 58/181 (32%), Positives = 84/181 (46%)
Frame = +2
Query: 311 IASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQW 490
I SI +EE + ++ ++ A+ELN+SCP+ G G+ P + +
Sbjct: 98 IVSIAGRTSEEFTQMAARLSQYDEVGAIELNISCPNVSGGVDFGIC----PETCRDLIAS 153
Query: 491 VRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGRE 670
VR P KLTPN+ I +A AA EGGA G+SAINT+ G+ W
Sbjct: 154 VRAQCTKPLLAKLTPNVARIADVAAAAEEGGADGISAINTLLGM------AVDWRRQKPL 207
Query: 671 KHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICS 850
GGLSG A +P+ LR V I R + + ++F++ GA VQI +
Sbjct: 208 LGNVMGGLSGPAIKPVALRCVYQIAQR-VKIPVIGIGGIGTIDDVMEFLVAGATAVQIGT 266
Query: 851 A 853
A
Sbjct: 267 A 267
>UniRef50_A0Z3E6 Cluster: Dihydroorotate
dehydrogenase/oxidoreductase, FAD-binding protein; n=5;
Bacteria|Rep: Dihydroorotate
dehydrogenase/oxidoreductase, FAD-binding protein -
marine gamma proteobacterium HTCC2080
Length = 551
Score = 83.4 bits (197), Expect = 1e-14
Identities = 63/187 (33%), Positives = 86/187 (45%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFF 520
E++ ++K E AD ELNLSCPH SG G+A GQDP +V I V++ + P
Sbjct: 106 EEFVAVAKILEPV-ADGFELNLSCPHA---SGYGMAMGQDPKIVHEIIAAVKQVVSKPVI 161
Query: 521 VKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSG 700
KLTPN+T+I I AA + GA G+ AINTV G + G + G GG+SG
Sbjct: 162 PKLTPNVTNIAEIGQAALDAGADGLCAINTV-GPGYTESHGEAVLSNG------VGGMSG 214
Query: 701 NATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVV 880
P L+ + + SA GA +V I SA+ D +
Sbjct: 215 KGVLPTALKCIREL-RAITDKPIIGCGGLSSAADVNAAKHAGATIVGIGSALSGMDTEDL 273
Query: 881 DDYITGL 901
Y + L
Sbjct: 274 QRYFSTL 280
>UniRef50_Q1MQG1 Cluster: Dihydroorotate dehydrogenase; n=2;
Deltaproteobacteria|Rep: Dihydroorotate dehydrogenase -
Lawsonia intracellularis (strain PHE/MN1-00)
Length = 314
Score = 83.0 bits (196), Expect = 2e-14
Identities = 66/181 (36%), Positives = 92/181 (50%), Gaps = 2/181 (1%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
+IA++ + EE L + A G ALE+N+SCP+ +SG G GQDP L +++
Sbjct: 105 VIANLYATSVEEFSELTAILAAEEGVAALEVNVSCPNV--KSG-GTFFGQDPSLAAKVTE 161
Query: 488 WVRK-AIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGL-MSIRADGTPWPAV 661
V K A P VKL+PN+TDI IA A GA +S INT++G+ + IR +
Sbjct: 162 AVCKNAGSKPVMVKLSPNVTDITIIAKAVESAGADAISCINTLTGMAVDIRKRKS----- 216
Query: 662 GREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQ 841
T GGLSG +P+ LR V + + SA L+FI+ GA VQ
Sbjct: 217 --LLSTVIGGLSGPGIKPIALRCVWEV-CKAVNIPVIGIGGITSARDVLEFILVGAHAVQ 273
Query: 842 I 844
I
Sbjct: 274 I 274
>UniRef50_Q2NEG1 Cluster: PyrD; n=1; Methanosphaera stadtmanae DSM
3091|Rep: PyrD - Methanosphaera stadtmanae (strain DSM
3091)
Length = 306
Score = 80.6 bits (190), Expect = 1e-13
Identities = 77/255 (30%), Positives = 128/255 (50%), Gaps = 2/255 (0%)
Frame = +2
Query: 98 GWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVT 277
G G VTK+FS++ + + +P IV+ + G G S +E E+ + +
Sbjct: 36 GAGGIVTKSFSIEANDGYD-NPTIVK-IEGGVINSVGLAS-PGVEAKKEELK-----DLN 87
Query: 278 ELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQ 457
E++ P +IASI +EE ++ ++ + + DA ELN+SCPH + G G G+
Sbjct: 88 EIRDKTP---VIASIYGD-SEEVFSDVANQTKDY-VDAFELNVSCPHA--KCGFGSNIGE 140
Query: 458 DPVLVKGISQWVRKAIK-IPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIR 634
+P L I V+ IK +P VKLTPN+TDI IA AA + GA ++ IN+V +R
Sbjct: 141 NPELTHDIVSSVKDNIKDVPIIVKLTPNVTDITEIAKAAEDAGADALTLINSVG--PGLR 198
Query: 635 AD-GTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQ 811
D T P + + +GG++G +P+ L+ V + + AL+
Sbjct: 199 IDYKTARPIL----NNVFGGIAGPMIKPIALKCVYKT-YETVDIPLFGVGGIRTYKDALE 253
Query: 812 FIMCGAPVVQICSAV 856
F+ GA ++QI +++
Sbjct: 254 FLYAGASLLQIGTSI 268
>UniRef50_Q9YFI6 Cluster: Dihydroorotate dehydrogenase; n=3;
Desulfurococcales|Rep: Dihydroorotate dehydrogenase -
Aeropyrum pernix
Length = 306
Score = 80.6 bits (190), Expect = 1e-13
Identities = 68/212 (32%), Positives = 97/212 (45%), Gaps = 1/212 (0%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
+IASI E W ++ E AG A+ELNLSCPH +G GL GQDP V +
Sbjct: 99 VIASIAGGAPGE-WVEMASTLEEAGVSAVELNLSCPH---FAGGGLELGQDPAAVASVVS 154
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGR 667
V ++IP KL + +V A A E GA G++ IN++ M I P +G
Sbjct: 155 AVASTLRIPVIAKLGYS-DRLVDAASKALEAGARGLTLINSMRA-MKIDVYAKK-PVLGN 211
Query: 668 EKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQIC 847
GGLSG P+ +RAV + +S E A++F + GA VQ+
Sbjct: 212 R----VGGLSGKPIHPIAVRAVYEVYGE-TRADIFAAGGVESWEDAVEFYLAGAKAVQVG 266
Query: 848 SAVQNQDFTVVDDYITGLKAPV-VHSFXGLTD 940
+A V+ + G++ + V F L D
Sbjct: 267 AAFITIGPHVLRSIVEGVRRYLWVEGFRSLQD 298
>UniRef50_A0LD69 Cluster: Dihydroorotate dehydrogenase family
protein; n=7; Proteobacteria|Rep: Dihydroorotate
dehydrogenase family protein - Magnetococcus sp. (strain
MC-1)
Length = 312
Score = 79.8 bits (188), Expect = 2e-13
Identities = 58/185 (31%), Positives = 95/185 (51%), Gaps = 2/185 (1%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
+IA+I S E+ + +++ + + A+E+N+SCP+ + G G+A G DP + + +
Sbjct: 102 LIANISGSTTEQ-YGEIARIFDQSPVAAIEINISCPNV--KEG-GIAFGSDPDMAAAVVE 157
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGR 667
VR+A P KL+PN+TDI ++A A E G+ +S INT+ G M+I P +G
Sbjct: 158 EVRRATTKPIITKLSPNVTDITTVAKRAIEAGSDALSVINTLMG-MAIDLKKRR-PVLG- 214
Query: 668 EKHTTYGGLSGNATRPMGLRAVSAIGN--RXXXXXXXXXXXXDSAESALQFIMCGAPVVQ 841
GGLSG A +P+ L V R SA+ L+F + GA
Sbjct: 215 ---NLQGGLSGPAVKPVALLKVWQTYQLARQHQIPIIGQGGIASADDVLEFFLVGASATG 271
Query: 842 ICSAV 856
+C+++
Sbjct: 272 LCTSL 276
>UniRef50_A5FPW7 Cluster: Dihydroorotate dehydrogenase family
protein; n=21; Bacteria|Rep: Dihydroorotate
dehydrogenase family protein - Dehalococcoides sp. BAV1
Length = 324
Score = 79.4 bits (187), Expect = 2e-13
Identities = 57/173 (32%), Positives = 87/173 (50%), Gaps = 2/173 (1%)
Frame = +2
Query: 341 EDWTLLSKKAEAA-GADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPF 517
ED+ L+++ + G +E+N+SCP+ + G + G P ++ VR A +P
Sbjct: 127 EDYAELARRLDKVPGVSGIEVNISCPN--VKCGC-IEFGSSPESAAKVTDVVRNATTLPL 183
Query: 518 FVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRAD-GTPWPAVGREKHTTYGGL 694
VKLTPN + I +A A + GA +S INT+ G+ R D P +G HT GGL
Sbjct: 184 IVKLTPNTSSITELAKAVADAGADAISLINTLRGM---RIDIKKRRPVLG--NHT--GGL 236
Query: 695 SGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
SG A +P+ + V + +AE AL+F+M GA +QI +A
Sbjct: 237 SGPAIKPVAISMVYQVAGAVNVPVIGGGGIM-NAEDALEFLMAGATAIQIGTA 288
>UniRef50_A0RV22 Cluster: Dihydroorotate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: Dihydroorotate dehydrogenase
- Cenarchaeum symbiosum
Length = 281
Score = 79.0 bits (186), Expect = 3e-13
Identities = 56/158 (35%), Positives = 79/158 (50%)
Frame = +2
Query: 380 GADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSI 559
GA A E+NLSCPH + +GL G DP LV I ++A +P F K+ T +
Sbjct: 98 GAAAFEINLSCPH---VAKVGLEVGDDPGLVGEIVSAAKRAADVPVFAKVGLGSTHYIKT 154
Query: 560 AVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSA 739
A AA E GA ++AINTV MSI + P + +GGLSG RP+ +R V
Sbjct: 155 AGAAAEAGADAITAINTVRA-MSIDVEAKK-PVLS----NGFGGLSGPPIRPIAVRCVWE 208
Query: 740 IGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+ ++ S E A++ ++ GA VQ+ SA
Sbjct: 209 LASK-YDVPVIGCGGVSSWEDAIEMMLAGACAVQVGSA 245
>UniRef50_Q8KC29 Cluster: Dihydroorotate dehydrogenase; n=10;
Chlorobiaceae|Rep: Dihydroorotate dehydrogenase -
Chlorobium tepidum
Length = 305
Score = 78.2 bits (184), Expect = 5e-13
Identities = 57/155 (36%), Positives = 77/155 (49%)
Frame = +2
Query: 380 GADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSI 559
G A ELNLSCP+ GE + G P + I +RK + VKLTPN+T I +I
Sbjct: 122 GIAAYELNLSCPNVKGEC---MIMGVSPDATREIVSTLRKQTRRHLMVKLTPNVTSISAI 178
Query: 560 AVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSA 739
A+AA E GA VS INTV G+ P K+ T GGLSG A +P+ L V
Sbjct: 179 ALAAEEAGADSVSLINTVVGMAVDYRKRKP-----LLKNVT-GGLSGPAIKPIALAKVWE 232
Query: 740 IGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQI 844
+ ++ S A++F++ GA +QI
Sbjct: 233 V-SKAVKIPIVGMGGIASFSDAMEFLLVGASAIQI 266
>UniRef50_Q1IUQ6 Cluster: Dihydroorotate dehydrogenase family
protein; n=3; Bacteria|Rep: Dihydroorotate dehydrogenase
family protein - Acidobacteria bacterium (strain
Ellin345)
Length = 321
Score = 77.0 bits (181), Expect = 1e-12
Identities = 56/191 (29%), Positives = 91/191 (47%)
Frame = +2
Query: 281 LKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQD 460
L + N + ++ + NE+ + + G A ELN+SCP+ + G G+ G D
Sbjct: 104 LLRKLKNVPVFCNVYGTCNEDYEETIRILNDGEGITAYELNVSCPNT--QHG-GMTFGAD 160
Query: 461 PVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRAD 640
P L+ + +KA P VKL+PN+T I +A A + GA +S +NT G M+I +
Sbjct: 161 PTLLAEVVTVAKKAATRPLIVKLSPNVTSIPQMAKIAQDAGADAISLVNTFVG-MAIDVE 219
Query: 641 GTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIM 820
T P + GLSG A +P+ LR V + +AE ++F++
Sbjct: 220 -TRKPRIS----NIVAGLSGPAIKPIALRMVYEAA-KTVTIPVIGIGGISTAEDIVEFML 273
Query: 821 CGAPVVQICSA 853
GA V++ +A
Sbjct: 274 AGATAVEVGTA 284
>UniRef50_UPI00015BD53C Cluster: UPI00015BD53C related cluster; n=1;
unknown|Rep: UPI00015BD53C UniRef100 entry - unknown
Length = 310
Score = 76.6 bits (180), Expect = 2e-12
Identities = 61/199 (30%), Positives = 95/199 (47%), Gaps = 1/199 (0%)
Frame = +2
Query: 311 IASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQW 490
IA++ EE ++ + A ELN+SCP+ + G G+ GQDPV+++ + +
Sbjct: 97 IANVFGETEEEYIEVIRILEDVPKISAYELNVSCPNV--KKG-GVVFGQDPVVLRSLIEK 153
Query: 491 VRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGRE 670
++ K P VKL+PN+TDI A E A G+ INT+ G+ + P+ A
Sbjct: 154 IKSFAKKPLLVKLSPNVTDITEFAKICIEAKADGIVLINTLIGMKIDIYNERPFLA---- 209
Query: 671 KHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSA-ESALQFIMCGAPVVQIC 847
T GGLSG A P+ +R + + S AL+ I+ GA VQI
Sbjct: 210 --TKTGGLSGPAILPIAVRMIWQTYEKYGKAIPIIGVGGISTYVDALEHILAGASAVQIG 267
Query: 848 SAVQNQDFTVVDDYITGLK 904
+A + + + D I G+K
Sbjct: 268 TANFYKPLSPL-DVIEGIK 285
>UniRef50_Q64TN0 Cluster: Dihydroorotate dehydrogenase; n=6;
Bacteroides|Rep: Dihydroorotate dehydrogenase -
Bacteroides fragilis
Length = 303
Score = 75.8 bits (178), Expect = 3e-12
Identities = 57/155 (36%), Positives = 83/155 (53%)
Frame = +2
Query: 389 ALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVA 568
A+ELN+SCP+ + G G+A G V + Q VR A K VKL+PN+TDI +A A
Sbjct: 123 AIELNISCPNV--KQG-GMAFGVTTKGVSEVVQAVRSAYKKTLIVKLSPNVTDIAEMARA 179
Query: 569 AYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGN 748
A GA VS INT+ G M+I A+ P + T GG+SG A +P+ LR V +
Sbjct: 180 AEANGADSVSLINTLLG-MAIDAE-RKRPILS----TVTGGMSGAAVKPIALRMVWQVA- 232
Query: 749 RXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+ + + A++F++ GA +QI +A
Sbjct: 233 KAVNIPVIGLGGIMNWKDAVEFMLAGASAIQIGTA 267
>UniRef50_Q891J3 Cluster: Dihydroorotate dehydrogenase; n=16;
Bacteria|Rep: Dihydroorotate dehydrogenase - Clostridium
tetani
Length = 304
Score = 74.1 bits (174), Expect = 9e-12
Identities = 54/172 (31%), Positives = 85/172 (49%), Gaps = 1/172 (0%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFF 520
ED+ K D +ELN+SCP+ + E GM A G + + V+K K P
Sbjct: 110 EDYLGAIDKLNKTDIDLIELNISCPN-VKEGGM--AFGIKSKVAYDVVSRVKKICKKPLI 166
Query: 521 VKLTPNITDIVSIAVAAYEGGASGVSAINTVSGL-MSIRADGTPWPAVGREKHTTYGGLS 697
VKL+PN DIV +AV EGGA +S +NT + + I++ + + + GLS
Sbjct: 167 VKLSPNAEDIVDMAVKCCEGGAEAISLVNTFKAMAVDIKSRKSVF-------NNITAGLS 219
Query: 698 GNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
G A +P+ LR V + + ++ + A++FIM GA +Q+ +A
Sbjct: 220 GVAIKPIALRMVYEV-CKNVNVPVIGLGGINNWQDAIEFIMVGATAIQVGTA 270
>UniRef50_A6L5H1 Cluster: Dihydroorotate dehydrogenase; n=1;
Bacteroides vulgatus ATCC 8482|Rep: Dihydroorotate
dehydrogenase - Bacteroides vulgatus (strain ATCC 8482 /
DSM 1447 / NCTC 11154)
Length = 303
Score = 72.5 bits (170), Expect = 3e-11
Identities = 58/158 (36%), Positives = 82/158 (51%), Gaps = 3/158 (1%)
Frame = +2
Query: 389 ALELNLSCPHGMGESGMGL---ACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSI 559
A+ELN+SCP+ + + GM ACG V VK VR K VKL+PN+TDI I
Sbjct: 123 AIELNISCPN-VKQGGMAFGVSACGCSEV-VKA----VRNVYKKTLIVKLSPNVTDITEI 176
Query: 560 AVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSA 739
A AA GA VS INT+ G M++ A+ P + T GG+SG A +P+ LR V
Sbjct: 177 ARAAEASGADSVSLINTLLG-MAVDAEKRR-PVLS----TITGGMSGAAVKPIALRMVWQ 230
Query: 740 IGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+ + + A++F++ GA +QI +A
Sbjct: 231 VA-KAVNIPVIGLGGIMGWKDAVEFMLAGATAIQIGTA 267
>UniRef50_A5NSG9 Cluster: Dihydroorotate dehydrogenase family
protein; n=5; Proteobacteria|Rep: Dihydroorotate
dehydrogenase family protein - Methylobacterium sp. 4-46
Length = 351
Score = 71.3 bits (167), Expect = 6e-11
Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 1/190 (0%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFF 520
E + L+ + G +E N+SCP+ + E G A D +++ +R A +P +
Sbjct: 140 EGFARLAAELTIPGVAGIEANISCPN-IEEDGRAFAMRADSTAA--VTRQLRAATDLPLW 196
Query: 521 VKLTPNITDIVSIAVAAYEGGASGVSAINTVSGL-MSIRADGTPWPAVGREKHTTYGGLS 697
VKLTPN ++ +A AA E GA V NT+ + + +R T P +G GGLS
Sbjct: 197 VKLTPNTAEMPEVARAAQEAGADAVVVANTIPSMAIDLR---TFKPCLG----NIMGGLS 249
Query: 698 GNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTV 877
G A +P+ LR V + +AE A ++++ GA VQ+ +A Q
Sbjct: 250 GPAVKPIVLRHVYLCA-KAVTIPVIGCGGIGTAEDAAEYMLAGAAAVQVGTATFLQP-AA 307
Query: 878 VDDYITGLKA 907
+ I GL+A
Sbjct: 308 MTTIIDGLEA 317
>UniRef50_A1RZC9 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Thermofilum pendens Hrk 5|Rep:
Dihydroorotate dehydrogenase family protein -
Thermofilum pendens (strain Hrk 5)
Length = 299
Score = 70.1 bits (164), Expect = 1e-10
Identities = 63/201 (31%), Positives = 96/201 (47%), Gaps = 2/201 (0%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAA-GADALELNLSCPHGMGESGMGLACGQDPVLVKGIS 484
+IASI S +E + AEA G DALELN SCPH G+G DP V GI
Sbjct: 96 VIASIGASTPDEALRI----AEALEGFDALELNASCPH---VKGLGADLMSDPDAVYGIV 148
Query: 485 QWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGL-MSIRADGTPWPAV 661
K+ F+KL+P+ D +++A AY G G +AINT + + + A P +
Sbjct: 149 S-ALKSSGYRVFLKLSPH-GDYLAVARKAYSAGVDGFTAINTAKAMVIDVYARK---PVL 203
Query: 662 GREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQ 841
G GGLSG A P+ +R V + + A++ I+ GA V
Sbjct: 204 G----GVVGGLSGRAIHPIAVRVVYELHREFPEVPVIGTGGVEGWVEAVELILAGASAVG 259
Query: 842 ICSAVQNQDFTVVDDYITGLK 904
+ +A++ + F V+ + + G++
Sbjct: 260 VGTALK-RGFEVIGEILGGIE 279
>UniRef50_A6LJ97 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Thermosipho melanesiensis BI429|Rep:
Dihydroorotate dehydrogenase family protein -
Thermosipho melanesiensis BI429
Length = 360
Score = 68.9 bits (161), Expect = 3e-10
Identities = 62/217 (28%), Positives = 96/217 (44%), Gaps = 1/217 (0%)
Frame = +2
Query: 206 GQGSF-LNIELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAG 382
G+ +F +N EL SE W + + K+ K +I S+ Y ED +L +
Sbjct: 60 GENNFVMNAELWSELPPETWIKEILPKLKNELKKPLIVSV--GYTIEDMEILIPQLNEY- 116
Query: 383 ADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIA 562
ADA E++ H +G+ D + I + +RK P F+KL+P+I D V
Sbjct: 117 ADAFEIST---HYVGK---------DYNTIANIVKAIRKNTNKPIFMKLSPHIPDPVEFT 164
Query: 563 VAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAI 742
E GA+G+ AIN+ M I +G EK + LSG +P+ L V I
Sbjct: 165 KTILENGANGIVAINSWGPTMKIDIKNRK-TLIGNEKGQVW--LSGPVIKPIALSIVKTI 221
Query: 743 GNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+ SAE ++F++ GA VQ+ S+
Sbjct: 222 RDAFPDITIIGVGGIKSAEDVIEFLLSGADAVQLLSS 258
>UniRef50_A3DL41 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Staphylothermus marinus F1|Rep:
Dihydroorotate dehydrogenase family protein -
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 /
F1)
Length = 406
Score = 68.5 bits (160), Expect = 4e-10
Identities = 76/273 (27%), Positives = 118/273 (43%), Gaps = 19/273 (6%)
Frame = +2
Query: 92 EQGWGFAVTKTFSLDKDMVTNVSPRIV-RGVTSGE---NYGPGQ--------GSF----- 220
+ G G V KT S+ +V S V RG+ + +GPG G++
Sbjct: 36 DNGVGAVVAKTISVRPAIVPRPSMGAVDRGIVRSQILKTFGPGNVRIVNADSGNYRFIYA 95
Query: 221 -LNIELISE-KCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADAL 394
LN EL S+ E Y+ + +KK K + I Y E+ LL K + AGA+A+
Sbjct: 96 LLNAELWSDIPAEHYFEREYPIVKKYAEEKGVPFIISIGYKPEELQLLGPKCQKAGANAI 155
Query: 395 ELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAY 574
E + H +G+ PV+ ++ +R+ + IP F KL+P +I +
Sbjct: 156 EFST---HYIGKD-------YRPVVEA--AKALREVVDIPIFAKLSPFTPNIPELVKELE 203
Query: 575 EGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRX 754
+ G G+ A NT+ + I + T P VG YG +SG A +P+ L AV A +
Sbjct: 204 KVGVDGIVATNTIGPALHIDIE-TGLPIVGGP--NGYGWMSGPALKPLAL-AVVAEAAKN 259
Query: 755 XXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+++ M GA VQIC+A
Sbjct: 260 THLPVIGVGGISKGTDVIEYFMAGASAVQICTA 292
>UniRef50_O29513 Cluster: Dihydroorotate dehydrogenase; n=1;
Archaeoglobus fulgidus|Rep: Dihydroorotate dehydrogenase
- Archaeoglobus fulgidus
Length = 299
Score = 67.3 bits (157), Expect = 1e-09
Identities = 57/192 (29%), Positives = 88/192 (45%), Gaps = 2/192 (1%)
Frame = +2
Query: 287 KDFPNKVIIASIMCSYNEEDWTLLSKKAEAA--GADALELNLSCPHGMGESGMGLACGQD 460
KD+ N+ + + ++ E+++ L ++A ELNLSCPH G GL G D
Sbjct: 85 KDYTNEAPLLISLYGHSVEEFSDLVDTFDSALPYLHGYELNLSCPH---VKGAGLDIGMD 141
Query: 461 PVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRAD 640
L I + ++ K P F KL+ + D + +A + G G++ NT+ G+
Sbjct: 142 LELSAAIVEELKGKTKNPVFAKLSA-MHDYLKLAKVLEDAGVDGITISNTLRGMKIDIMS 200
Query: 641 GTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIM 820
G P + GG+SG A +P+ L+ V + + S E L+FIM
Sbjct: 201 GKPVLS------NLSGGVSGPAIKPIALKCVYDL-YKEIEVPIVGCGGITSFEDVLEFIM 253
Query: 821 CGAPVVQICSAV 856
GA VQI SAV
Sbjct: 254 AGARAVQIGSAV 265
>UniRef50_Q1AVZ1 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Rubrobacter xylanophilus DSM 9941|Rep:
Dihydroorotate dehydrogenase family protein -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 304
Score = 63.3 bits (147), Expect = 2e-08
Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 1/172 (0%)
Frame = +2
Query: 341 EDWTLLSKKAEAAG-ADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPF 517
E++ LL + A G A A+ELNLSCP+ E G + C + + ++ R A +P
Sbjct: 103 EEFALLCGRVAADGRAAAIELNLSCPNV--ERGGQVFCAGPSAVEEVVAACRRAAPDVPL 160
Query: 518 FVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLS 697
KL + +V A+AA GA G++ +NTV L D + R GGLS
Sbjct: 161 LAKLA--LEGVVQNALAAEAAGADGLTVMNTVPALA---VDARARRVLLR------GGLS 209
Query: 698 GNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
G A +P+ LRAV + + A+ A +F++ GA VQ+ SA
Sbjct: 210 GPAIKPLALRAVYDVASAAEIPVVGCGGVCSGADVA-EFMLAGARAVQVGSA 260
>UniRef50_A4M861 Cluster: Dihydroorotate dehydrogenase family
protein; n=2; Bacteria|Rep: Dihydroorotate dehydrogenase
family protein - Petrotoga mobilis SJ95
Length = 363
Score = 62.1 bits (144), Expect = 4e-08
Identities = 64/223 (28%), Positives = 96/223 (43%), Gaps = 3/223 (1%)
Frame = +2
Query: 194 NYGPGQGSFLNIELISEKCEAYWCQSVTELKKDFPNKV---IIASIMCSYNEEDWTLLSK 364
N +G F+N EL SE W ++K++P V + I Y ED +
Sbjct: 58 NMAQVKGGFINTELWSELSLEQW------IEKEYPQVVETGLPVIIGVGYTSEDIKEVIP 111
Query: 365 KAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNIT 544
K E ADA EL+ H +G DP + + ++ +P VKL+P +
Sbjct: 112 KVERF-ADAFELST---HYLGN---------DPTPMINSIRAAKETTDLPVMVKLSPQV- 157
Query: 545 DIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGL 724
DI A A GA G+ IN+ + I + P +G E +G LSG A P+ L
Sbjct: 158 DIPKFAKEAENAGADGLVLINSFGPTLDIDLESGK-PLLGSENG--FGWLSGQAIFPLAL 214
Query: 725 RAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
R+V R ++ + A++ IM GA VQ+C+A
Sbjct: 215 RSVFE-AVRSVNIPVVGVGGINTGKEAIKMIMAGAQAVQVCTA 256
>UniRef50_A3DM44 Cluster: Dihydroorotate dehydrogenase family
protein; n=1; Staphylothermus marinus F1|Rep:
Dihydroorotate dehydrogenase family protein -
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 /
F1)
Length = 301
Score = 56.0 bits (129), Expect = 2e-06
Identities = 48/187 (25%), Positives = 85/187 (45%)
Frame = +2
Query: 344 DWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFV 523
++ +L++KA A +ALELNLSCPH G G+ ++K ++ V IP +
Sbjct: 105 EFQILAEKALDARPEALELNLSCPH---TPGFGVDTVATDEVLKHVALNVSSVSNIPVWG 161
Query: 524 KLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGN 703
KL + I+ + G V INT+ G+ G P G +GGLSG
Sbjct: 162 KLGFS-RRIIRESEILLNNGVDAVVLINTLPGMFIDVYVGKPVLTHG------FGGLSGP 214
Query: 704 ATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVVD 883
A P+ + +V + D +++++ ++ GA +QI + + +V+
Sbjct: 215 AIHPVAVYSVYKVYEELGAEIIGVGGVID-WKTSVELLLAGAKAIQIGTGFYMVGYNIVN 273
Query: 884 DYITGLK 904
+ + G+K
Sbjct: 274 NILDGIK 280
>UniRef50_Q8A841 Cluster: Putative dihydropyrimidine dehydrogenase
[NADP+]; n=6; Bacteroides|Rep: Putative
dihydropyrimidine dehydrogenase [NADP+] - Bacteroides
thetaiotaomicron
Length = 326
Score = 54.8 bits (126), Expect = 6e-06
Identities = 56/209 (26%), Positives = 95/209 (45%)
Frame = +2
Query: 230 ELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLS 409
E I E A + + E KK+ + IIASI C Y++ +W +K+ + AGADALE+N+
Sbjct: 74 EYIREHKLAEYLTLIKESKKEC-SIPIIASINC-YSDSEWVDFAKQIQEAGADALEINIL 131
Query: 410 CPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGAS 589
+S + G I + +++ + IP +KL N+T+ V++ Y GA+
Sbjct: 132 AL----QSDVQYTYGSFEQRHIDILRHIKQTVTIPVIMKLGDNLTNPVALIDQLYANGAA 187
Query: 590 GVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXX 769
V N I + V E +T L AT + S++ N+
Sbjct: 188 AVVLFNRFY-QPDINIEN--MEQVSGEVFSTSADL---ATPLRWIGIASSVVNKIDYAAS 241
Query: 770 XXXXXXDSAESALQFIMCGAPVVQICSAV 856
+ E+ ++ I+ GA V++CSA+
Sbjct: 242 GGVA---NPEAVVKAILAGASAVEVCSAI 267
>UniRef50_O08358 Cluster: Dihydroorotate dehydrogenase; n=4;
Sulfolobaceae|Rep: Dihydroorotate dehydrogenase -
Sulfolobus acidocaldarius
Length = 291
Score = 54.0 bits (124), Expect = 1e-05
Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 2/172 (1%)
Frame = +2
Query: 392 LELNLSCPH--GMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAV 565
+ELN+S P+ G GES + V+ I + V+ +K P FVKL P +IV IA
Sbjct: 115 IELNVSSPNRRGFGESNL--------TYVEEIVKNVKSIVKKPVFVKLGP-WDNIVEIAG 165
Query: 566 AAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIG 745
A GA G++ INT+ G++ D P + G GG+SG + +R + +
Sbjct: 166 RALSAGADGLTLINTLKGMLIDVEDFKPILSYGT------GGISGKCIHALAVRVIHDVF 219
Query: 746 NRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGL 901
D + A++ I GA +V + + + + F V+ + G+
Sbjct: 220 KEYEPEIIGVGGVFDWRD-AIELISVGAKLVGLGTVLVEKGFDVIREIREGI 270
>UniRef50_Q7MTB7 Cluster: Dihydroorotate dehydrogenase family
protein; n=3; Porphyromonadaceae|Rep: Dihydroorotate
dehydrogenase family protein - Porphyromonas gingivalis
(Bacteroides gingivalis)
Length = 326
Score = 52.8 bits (121), Expect = 2e-05
Identities = 58/200 (29%), Positives = 91/200 (45%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
+IASI C + + W +K+ E AGADALE+N+ + A + + V IS
Sbjct: 99 VIASINC-FRSDSWVDFAKQFEEAGADALEINVM---RLNTDLFFDANKAEQMYVDIISS 154
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGR 667
+ KAI+IP VKL+ + +I S+ GA GV N S I D V
Sbjct: 155 LI-KAIRIPVVVKLSKSFANIPSLVDKLRAAGAKGVVLFNR-SYQPDIDIDKV--QMVAG 210
Query: 668 EKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQIC 847
+ T+ G +S + R G+ VSA+ E+AL+ ++ GA V QIC
Sbjct: 211 DVFTSAGEIS-DTIRHAGI--VSAL---VPGISIASSTGIHDGEAALKCLLAGAHVTQIC 264
Query: 848 SAVQNQDFTVVDDYITGLKA 907
+ + + V + I +++
Sbjct: 265 TVLYKKGPQFVAEMIATIES 284
>UniRef50_A2EKA7 Cluster: Dihydroorotate dehydrogenase family
protein; n=3; Trichomonas vaginalis G3|Rep:
Dihydroorotate dehydrogenase family protein -
Trichomonas vaginalis G3
Length = 365
Score = 52.4 bits (120), Expect = 3e-05
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 2/214 (0%)
Frame = +2
Query: 218 FLNIELISEKCEAYWCQSVTELKKDFPNKVIIASIMCS--YNEEDWTLLSKKAEAAGADA 391
FLN EL +E W + ++ N+ I I CS Y E+ ++ K A D
Sbjct: 67 FLNTELWTELTPEQWLEHEYPKIREVCNQAKIPMI-CSMGYTAEEIAKMAPKV-APFCDG 124
Query: 392 LELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAA 571
LEL+ H +G+ + QD I + + P +VKL+P D A AA
Sbjct: 125 LELST---HYIGDDPKPM---QD-----AIKAAIHGSGGKPVYVKLSP-FRDAPIAAKAA 172
Query: 572 YEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNR 751
GA+G+ +N+ +++ + P +G + YG +SG A +P+ LR V + +
Sbjct: 173 KAAGATGLVCVNSFGPTLALDIERKGAPFMGST--SKYGWVSGPAIKPLALRVVYDVC-K 229
Query: 752 XXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
+ A++F+M GA + IC+A
Sbjct: 230 EVDLPVVGVGGISNGRDAIEFLMAGAQALGICTA 263
>UniRef50_Q54XQ6 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 435
Score = 52.0 bits (119), Expect = 4e-05
Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Frame = +2
Query: 335 NEEDWTLLSKKAEAAGADALELNLSCPHGMGESG-MGLACGQDPVLVKGISQWVRKAIKI 511
NE +W + + K DA++LNL CP + G G P ++ I Q + K IK+
Sbjct: 116 NEPEWVVKAAKYIEDHCDAIDLNLGCPQQIARRGNYGSFLLDKPHIILPIVQELHKHIKV 175
Query: 512 PFF--VKLTPNITDIVSIAVAAYEGG 583
P F ++L PN+ D + +A+ E G
Sbjct: 176 PIFCKIRLLPNLDDTIKLALQLQEAG 201
>UniRef50_A0ZZT0 Cluster: Putative uncharacterized protein; n=2;
Bifidobacterium adolescentis|Rep: Putative
uncharacterized protein - Bifidobacterium adolescentis
(strain ATCC 15703 / DSM 20083)
Length = 380
Score = 51.2 bits (117), Expect = 7e-05
Identities = 43/125 (34%), Positives = 58/125 (46%), Gaps = 4/125 (3%)
Frame = +2
Query: 380 GADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAI-KIPFFVKLT--PNITDI 550
GA +E+N SCP+ E L C DP LV I++ V+ I P VKL PN TD+
Sbjct: 207 GAGLMEMNTSCPN---EGHNRLLC-HDPHLVGEITEAVKNEIGDRPLIVKLAYIPNDTDL 262
Query: 551 VS-IAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLR 727
+ + G G S INT+S + P GR++ G+ GNA R GL
Sbjct: 263 ETMVRETVGHGTVQGFSTINTISARLVDANGNQALPGAGRDR----SGVCGNAIRGAGLD 318
Query: 728 AVSAI 742
V +
Sbjct: 319 MVGRL 323
>UniRef50_A4FBL7 Cluster: Dihydroorotate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
Dihydroorotate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 338
Score = 49.2 bits (112), Expect = 3e-04
Identities = 49/175 (28%), Positives = 78/175 (44%), Gaps = 3/175 (1%)
Frame = +2
Query: 338 EEDWTLLSKKAEAAGAD---ALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIK 508
EE TL+ K +A A A+E N+SC H + + + VL + + +
Sbjct: 146 EEFVTLIDKINDAVPAGDIAAVEFNVSC-HNVNFDFNAII---ESVLAEAVPRSAH---- 197
Query: 509 IPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYG 688
P +KL+P+ D ++ A A + G S ++AINTV GL G P +G
Sbjct: 198 -PVILKLSPDY-DYLAHARLAAKHGVSALTAINTVKGLRLDPETGQPL------LKNRFG 249
Query: 689 GLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSA 853
GLSG A +P+GLR V+ + + + + ++ GA V + SA
Sbjct: 250 GLSGRAIKPIGLRVVAELRDAGVKLPIIATGGIRTFDDCREYFWAGADAVSLGSA 304
>UniRef50_A3ETM0 Cluster: Dihydroorotate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep: Dihydroorotate
dehydrogenase - Leptospirillum sp. Group II UBA
Length = 368
Score = 48.4 bits (110), Expect = 5e-04
Identities = 46/171 (26%), Positives = 79/171 (46%), Gaps = 10/171 (5%)
Frame = +2
Query: 260 WCQSVTELKKDFPN-KVIIASIMCSYNEE-----DWTLLSKKAEAAGADALELNLSCPHG 421
W + V E + +V++ S++ + EE D+ + A+ GA LE+N SCP+
Sbjct: 138 WMRDVGEALSSLSSGQVLVLSLVGTQREERDLAQDFVYTAHLAKETGAKILEVNFSCPNV 197
Query: 422 MGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITD---IVSIAVAAYEGGASG 592
G+ G Q+P I + +RK + F + + +D + V A
Sbjct: 198 KGKEGQ---LYQNPDASGEILKRIRKELGRDFHLIMKIGFSDNPEHLDRLVEATSPYLDA 254
Query: 593 VSAINTVSGLMSIRADGTP-WPAVGREKHTTYGGLSGNATRPMGLRAVSAI 742
+SAINTV+G + I +G P P GRE+ GL G+ + + L+ + +
Sbjct: 255 ISAINTVTGTI-INPEGKPALPGPGRER----SGLCGSGIKNLSLKTIRGL 300
>UniRef50_P28272 Cluster: Dihydroorotate dehydrogenase; n=72;
cellular organisms|Rep: Dihydroorotate dehydrogenase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 314
Score = 48.4 bits (110), Expect = 5e-04
Identities = 57/228 (25%), Positives = 99/228 (43%), Gaps = 4/228 (1%)
Frame = +2
Query: 212 GSFLNIELISEKCEAYWCQSVTELKKDFPNK-VIIASIMCSYNEEDWTLLSKKAEAAGAD 388
GS ++ L +E + Y+ V +K++P+ I S+ +E+ LL K ++
Sbjct: 67 GSINSMGLPNEGID-YYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNG 125
Query: 389 ALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTP--NITDIVSIA 562
ELNLSCP+ G+ + D L K + V K P VKL P + +A
Sbjct: 126 ITELNLSCPNVPGKPQV----AYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMA 181
Query: 563 VAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAI 742
E + V++IN++ + I D V + K+ +GG+ G +P L V A
Sbjct: 182 KILNEFPLAYVNSINSIGNGLFI--DVEKESVVVKPKN-GFGGIGGEYVKPTALANVRAF 238
Query: 743 GNR-XXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVVD 883
R S + A + ++CGA ++QI + +Q + + +
Sbjct: 239 YTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFE 286
>UniRef50_Q7N0H1 Cluster: Similar to dihydroorotate dehydrogenase
PyrD; n=1; Photorhabdus luminescens subsp.
laumondii|Rep: Similar to dihydroorotate dehydrogenase
PyrD - Photorhabdus luminescens subsp. laumondii
Length = 289
Score = 48.0 bits (109), Expect = 7e-04
Identities = 52/212 (24%), Positives = 85/212 (40%)
Frame = +2
Query: 221 LNIELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALEL 400
LN S+K YW + E K++ +I SI + E L+ + A LEL
Sbjct: 71 LNNTTYSKKTVEYWLTLLREFKEE--QLPVIVSIHAE-SPEALASLAVRISAVTDAPLEL 127
Query: 401 NLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEG 580
+SC H + P V ++ V++ PF VKL+ ++ AA EG
Sbjct: 128 GISCLHADDFTE------DTPERVFNYTKVVKERTNTPFAVKLSLG-DNLYGRVQAAVEG 180
Query: 581 GASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXX 760
GA ++ +T+SG+ A+ G G SG +PM L A+ + R
Sbjct: 181 GADAITLSDTISGIAFDTAN-------GEALLNGVCGYSGPGIKPMVLAAIYNLRKRGVT 233
Query: 761 XXXXXXXXXDSAESALQFIMCGAPVVQICSAV 856
++++ GA VQ+ +A+
Sbjct: 234 IPILGSGGVQDGNDVHEYLLAGANTVQVYTAL 265
>UniRef50_UPI0000F1DE0E Cluster: PREDICTED: similar to
Dihydropyrimidine dehydrogenase; n=1; Danio rerio|Rep:
PREDICTED: similar to Dihydropyrimidine dehydrogenase -
Danio rerio
Length = 403
Score = 47.2 bits (107), Expect = 0.001
Identities = 25/49 (51%), Positives = 29/49 (59%)
Frame = +2
Query: 698 GNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQI 844
GNA RP+ LRAVSAI DSAESALQF+ GA V+Q+
Sbjct: 341 GNAIRPIALRAVSAIAKALPDFPILATGGIDSAESALQFLHVGATVLQV 389
>UniRef50_Q7UHA6 Cluster: Dihydroorotate dehydrogenase; n=1;
Pirellula sp.|Rep: Dihydroorotate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 46.8 bits (106), Expect = 0.002
Identities = 61/239 (25%), Positives = 106/239 (44%), Gaps = 3/239 (1%)
Frame = +2
Query: 251 EAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGE 430
EAY ++++ LK + +IAS+ S + W +K+ E+AGADALE NL + +
Sbjct: 96 EAY-LRTISRLK-GICSVPVIASMNGS-SAGQWLQYAKEMESAGADALEFNLQ--QAVFD 150
Query: 431 SGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINT 610
S + + + VR+ + IP K++ T++ S+A + G +G+ + T
Sbjct: 151 SKE--TSNDIEARMCDLIRQVRELVVIPVAAKISQRYTNLSSMATQLRQVGVAGL-VLFT 207
Query: 611 VSGLMSIRADGTPWPAVGREKHT-TYGG-LSGNATRPMGLRAVSAIGNRXXXXXXXXXXX 784
+ D W T + GG L G G +A+S +
Sbjct: 208 HMPQWDVSTDRMHWTINWELSPTNSIGGILEGIVRARAGDQAISIAAS----------GG 257
Query: 785 XDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGLKAPVVHS-FXGLTDGRDSXP 958
++E A++ ++ GA VV + SAV + + D + G++ V S F L D R + P
Sbjct: 258 VSNSEDAIKAMIAGADVVMVTSAVYRRGPDAIRDIVDGIERHVESSRFRTLQDFRAACP 316
>UniRef50_A0ADR6 Cluster: Putative hihydroorotate dehydrogenase;
n=1; Streptomyces ambofaciens ATCC 23877|Rep: Putative
hihydroorotate dehydrogenase - Streptomyces ambofaciens
ATCC 23877
Length = 297
Score = 46.8 bits (106), Expect = 0.002
Identities = 53/217 (24%), Positives = 90/217 (41%), Gaps = 2/217 (0%)
Frame = +2
Query: 221 LNIELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALEL 400
LN S + WC + D +IAS+ + ++ L+ AG+ ALEL
Sbjct: 66 LNSTTYSRRPVGDWCAMLRRFADD--GLPVIASVHAE-SPDELAELADLVGQAGSPALEL 122
Query: 401 NLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLT--PNITDIVSIAVAAY 574
+SC + E G GL P V + VR+ +PF VKL + + V A+A
Sbjct: 123 GISC---LNEGG-GL--DDTPERVAAYTDAVRRRTPVPFSVKLAAGERLRERVEAALAC- 175
Query: 575 EGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRX 754
GA ++ +TV+GL ++ AD G + G SG +P+ L + +
Sbjct: 176 --GADAITLSDTVAGL-AVDAD------TGEVRLGGAFGYSGAGIKPLVLAEIFGLRRAG 226
Query: 755 XXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQ 865
++ +++ GA VQ+ +A+ +
Sbjct: 227 LTVPVMASGGVENGRDVAEYLSVGADAVQVYTALHRE 263
>UniRef50_P59626 Cluster: Dihydroorotate dehydrogenase A; n=4;
Lactobacillales|Rep: Dihydroorotate dehydrogenase A -
Enterococcus faecalis (Streptococcus faecalis)
Length = 311
Score = 46.8 bits (106), Expect = 0.002
Identities = 46/190 (24%), Positives = 79/190 (41%), Gaps = 3/190 (1%)
Frame = +2
Query: 284 KKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDP 463
+K+FP ++ S+ EE+ +L K E+ E NLSCP+ G+ +
Sbjct: 88 QKEFPEELRFLSVSGMNYEENIAILKKVQESEYTGVTEFNLSCPNLPGKPQIAYDFELTE 147
Query: 464 VLVKGISQWVRKAIKIPFFVKLTP--NITDIVSIAVAAYEGGASGVSAINTVSGLMSIRA 637
L+ + Q+ K P VKL P +I ++A + V++IN++ + I +
Sbjct: 148 KLLTEVFQFFTK----PLGVKLPPFFDIAHFDAMAEILNKFPLVYVNSINSIGNGLYIDS 203
Query: 638 DGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNR-XXXXXXXXXXXXDSAESALQF 814
D V + +GGL G +P L V A R + +
Sbjct: 204 DK---EEVVIKPKGGFGGLGGEYVKPTALANVRAFAQRLKPEIKIIGTGGITCGKDVFEH 260
Query: 815 IMCGAPVVQI 844
++CGA +VQ+
Sbjct: 261 LLCGATLVQV 270
>UniRef50_Q4AHC8 Cluster: Related to dihydroorotate dehydrogenase;
n=1; Chlorobium phaeobacteroides BS1|Rep: Related to
dihydroorotate dehydrogenase - Chlorobium
phaeobacteroides BS1
Length = 217
Score = 46.4 bits (105), Expect = 0.002
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Frame = +2
Query: 299 NKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGL-ACGQDPVLVK 475
N +IASI C +E W + E AGADA+ELN+ G+ L +C + +
Sbjct: 115 NIPVIASINCKTADE-WPKFAGLIEKAGADAIELNI----GIFPFDASLKSCEVEDQYI- 168
Query: 476 GISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAIN 607
I V+K + IP VKL+ T+I S+A + GA G+ N
Sbjct: 169 AILDAVKKEVTIPVSVKLSSYFTNICSVANQLVDHGAQGLVLFN 212
>UniRef50_Q4J443 Cluster: Dihydroorotate dehydrogenase precursor;
n=1; Azotobacter vinelandii AvOP|Rep: Dihydroorotate
dehydrogenase precursor - Azotobacter vinelandii AvOP
Length = 332
Score = 46.0 bits (104), Expect = 0.003
Identities = 37/101 (36%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLS-CPHGMGESGMGLACGQDPVLVKGIS 484
+IAS+ + + WT + E AGADALELNL P E G + VL
Sbjct: 102 VIASLNGA-SANHWTHYAALLEEAGADALELNLYFVPVDPLEPGTAVEQRYLEVLAA--- 157
Query: 485 QWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAIN 607
VR+ +KIP VK+ P + I ++A EGGA G+ N
Sbjct: 158 --VRRTVKIPVAVKMPPYFSAIGNMASRLLEGGADGLVIFN 196
>UniRef50_Q6AE78 Cluster: Dihydroorotate dehydrogenase; n=6;
Actinomycetales|Rep: Dihydroorotate dehydrogenase -
Leifsonia xyli subsp. xyli
Length = 343
Score = 46.0 bits (104), Expect = 0.003
Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 3/166 (1%)
Frame = +2
Query: 353 LLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLT 532
L+S +A A AD L +N+S P+ G G+ P+L S + K P VK+
Sbjct: 162 LISARALAPVADYLVVNVSSPNTPGLRGLQEREALAPLL----SAVKAASGKKPLLVKIA 217
Query: 533 PNITD--IVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNA 706
P++TD IV++A A E G +G+ A NT + +D A G GGLSG
Sbjct: 218 PDLTDEQIVAVARLAVELGLAGIIATNTTIARDGLSSDPAVVEAAGA------GGLSGAP 271
Query: 707 TRPMGLRAVSAI-GNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQ 841
L ++ I N ++A+ + + GA +VQ
Sbjct: 272 LAARSLEVLTLIRANVPPSLCVISVGGVETAQDVQRRLDAGATLVQ 317
>UniRef50_UPI0000DAE5CB Cluster: hypothetical protein
Rgryl_01000728; n=1; Rickettsiella grylli|Rep:
hypothetical protein Rgryl_01000728 - Rickettsiella
grylli
Length = 355
Score = 45.2 bits (102), Expect = 0.005
Identities = 42/137 (30%), Positives = 68/137 (49%), Gaps = 3/137 (2%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAI-KIPF 517
+D+ + A+ AGAD +ELN SCP+ M +S L D V I+ V K + IP
Sbjct: 172 QDFMTAALMAKEAGADIIELNFSCPNLM-KSDEPLYRNMD--CVSQITTRVVKCVGDIPL 228
Query: 518 FVKL--TPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGG 691
+K+ + + ++A G G+SAIN++S M + + PA G+ Y G
Sbjct: 229 LLKIGFIHEHEFPLKLLISAARAGVRGISAINSIS--MRV-LNQNHRPAFGKR---IYSG 282
Query: 692 LSGNATRPMGLRAVSAI 742
+SG R + L++V +
Sbjct: 283 ISGYPIRRLALQSVKKL 299
>UniRef50_Q2JDS8 Cluster: Dihydroorotate dehydrogenase; n=3;
Frankia|Rep: Dihydroorotate dehydrogenase - Frankia sp.
(strain CcI3)
Length = 313
Score = 45.2 bits (102), Expect = 0.005
Identities = 58/251 (23%), Positives = 102/251 (40%), Gaps = 20/251 (7%)
Frame = +2
Query: 173 RGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVTEL--KKDFPNKVIIASIMCSYNEED 346
R SG Y PG+ LN + + Y+ + + + K + S+ + ++
Sbjct: 47 RSGNSGNVYWPGRVYSLNALGLPNRGLDYYAAHLPGMVRRAHRAGKPLTVSV-AGFGVDE 105
Query: 347 WTLLSKKAEAAGADALELNLSCPH-GMGESGMGLAC---GQDPVLVKGISQWV------R 496
+ +S G D +ELNL+CP+ G + +AC G + + +
Sbjct: 106 YREISAVVARTGVDLIELNLACPNIWDGGTQKRIACFDPGHTATICTAVGDTLVAQAGAD 165
Query: 497 KAIKIPFFVKLTP--NITDIVSIA-----VAAYEGGASGVSAINTVSGLMSIRADGTPWP 655
A ++P+ VK++P + + +V +A VAA GG V+A+NT ++ D P
Sbjct: 166 PARRVPYGVKISPFSDPSALVELATVIDEVAARPGGPRFVTAVNTFPNAFAV--DDAHRP 223
Query: 656 AVGREKHTTYGGLSGNATRPMGLRAVSAIGN-RXXXXXXXXXXXXDSAESALQFIMCGAP 832
V E G+SG A +P+GL V + +++ GA
Sbjct: 224 VVDVE----LAGMSGPALKPVGLGQVRQLRRLLPESVDIIGVGGVTGGRDVADYLLAGAT 279
Query: 833 VVQICSAVQNQ 865
VQ +A N+
Sbjct: 280 AVQAATAFWNR 290
>UniRef50_Q7U3U2 Cluster: Dihydroorotate dehydrogenase; n=25;
Cyanobacteria|Rep: Dihydroorotate dehydrogenase -
Synechococcus sp. (strain WH8102)
Length = 396
Score = 44.4 bits (100), Expect = 0.008
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 4/178 (2%)
Frame = +2
Query: 383 ADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIP-FFVKLTPNITD--IV 553
AD +N+S P+ G + QD ++ + + +R+ P VK+ P++ D I
Sbjct: 196 ADYAVINVSSPNTPGLRDL-----QDSSQLRRLVERLRRLPACPPLLVKIAPDLEDEAID 250
Query: 554 SIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAV 733
IA A+E G +GV A+NT L + + GR GGLSG R L +
Sbjct: 251 GIARLAFEEGLAGVIAVNT--SLDRLGLEQRRLLQTGRTLAEEAGGLSGAPLRQRALEVI 308
Query: 734 SAI-GNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVVDDYITGLK 904
+ + DSAE A + I GA ++Q+ + Q +V + GL+
Sbjct: 309 RRLRASAGPALTLIGVGGIDSAEIAWERITAGASLIQLYTGWIFQGPELVPRILEGLQ 366
>UniRef50_Q2IG49 Cluster: Dihydrouridine synthase TIM-barrel protein
nifR3; n=2; Anaeromyxobacter|Rep: Dihydrouridine
synthase TIM-barrel protein nifR3 - Anaeromyxobacter
dehalogenans (strain 2CP-C)
Length = 352
Score = 44.0 bits (99), Expect = 0.011
Identities = 28/82 (34%), Positives = 45/82 (54%), Gaps = 5/82 (6%)
Frame = +2
Query: 368 AEAAGADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKL----T 532
A AGA +++N++CP + SG G A G+DP V+ + +R A+ +P VK+
Sbjct: 86 AVQAGAGMIDVNMACPVKKVCGSGAGAAMGRDPRKVEEAVRAIRAAVPVPVTVKIRAGWD 145
Query: 533 PNITDIVSIAVAAYEGGASGVS 598
+ V +A AA GGA+ V+
Sbjct: 146 EGEVNCVDVARAAEAGGAAAVA 167
>UniRef50_A5UU72 Cluster: Dihydroorotate dehydrogenase; n=4;
Chloroflexaceae|Rep: Dihydroorotate dehydrogenase -
Roseiflexus sp. RS-1
Length = 330
Score = 44.0 bits (99), Expect = 0.011
Identities = 49/170 (28%), Positives = 79/170 (46%), Gaps = 2/170 (1%)
Frame = +2
Query: 104 GFAVTKTFSLDKDMVTNVSPRIVRGVTSGE-NYGPGQGSFLNIELISEKCEAYWCQSVTE 280
G A FSL ++ +T+ + + + G ++ F ++E + E Y + V
Sbjct: 38 GAAAVVLFSLFEEQITHEARELDYYLDRGAYSFAESLTYFPDLEQYNLGVEPY-LEHVHA 96
Query: 281 LKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQD 460
LK+ + IIAS+ ++ DW ++K E AGADALELNL G A +
Sbjct: 97 LKQRV-SIPIIASLN-GPSDGDWVEYARKVEQAGADALELNLYF-LATDPDITGAAVEEQ 153
Query: 461 PV-LVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAIN 607
+ LV+ + + IP VK++P + I +IA E GA G+ N
Sbjct: 154 YLRLVRDVC----SRVTIPVAVKMSPFFSSIANIAKQFSEAGARGLVLFN 199
>UniRef50_Q6MRF1 Cluster: Transcription regulator homolog yacF; n=1;
Bdellovibrio bacteriovorus|Rep: Transcription regulator
homolog yacF - Bdellovibrio bacteriovorus
Length = 337
Score = 43.6 bits (98), Expect = 0.014
Identities = 29/82 (35%), Positives = 41/82 (50%), Gaps = 5/82 (6%)
Frame = +2
Query: 368 AEAAGADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKL----T 532
AEA G D ++LN CP + + G G A +DP V+ + V+ AIKIP +K+
Sbjct: 86 AEADGCDFVDLNFGCPVPKVVKKGAGSAILKDPAAVQKMVSTVKAAIKIPLTIKIRTGWD 145
Query: 533 PNITDIVSIAVAAYEGGASGVS 598
N + I AY G S V+
Sbjct: 146 ANSRNATEICNIAYNEGVSWVA 167
>UniRef50_Q5NRB0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Zymomonas mobilis
Length = 372
Score = 43.6 bits (98), Expect = 0.014
Identities = 44/138 (31%), Positives = 62/138 (44%), Gaps = 3/138 (2%)
Frame = +2
Query: 338 EEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAI-KIP 514
EED+ L ++ GA LE NLSCP+ E L C P LV+ I + ++ A+ P
Sbjct: 188 EEDYALAARMVAETGAPVLEANLSCPN---EGVNSLLCFDAP-LVQKIVEAIKAAVPDRP 243
Query: 515 FFVKLTPNITDIVSIAVAAYEGG--ASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYG 688
+K T D +A G SG S INT+S + G + R + G
Sbjct: 244 LLIK-TAYFKDNAKLADLVSRVGHLVSGFSTINTLSA-RPLDEKGQAALSPSRPE----G 297
Query: 689 GLSGNATRPMGLRAVSAI 742
G+ G+A R GL V +
Sbjct: 298 GVCGDAIRWAGLEMVQRL 315
>UniRef50_A2F0D1 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 333
Score = 43.2 bits (97), Expect = 0.019
Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Frame = +2
Query: 383 ADALELNLSCPHGMGES-GMGLACGQDPVLVKGISQWVRKAIKIPFFVK--LTPNITDIV 553
ADA++LN CP S G G + +P +V + +R+ +P VK + NI + +
Sbjct: 107 ADAIDLNCGCPESFATSRGTGSSLMSEPEIVADVVSALRRNYNVPISVKHRIHHNIEESI 166
Query: 554 SIAVAAYEGGASGVS 598
AVA GAS ++
Sbjct: 167 QFAVACENAGASAIA 181
>UniRef50_Q7US31 Cluster: Putative uncharacterized protein; n=1;
Pirellula sp.|Rep: Putative uncharacterized protein -
Rhodopirellula baltica
Length = 337
Score = 42.7 bits (96), Expect = 0.025
Identities = 30/85 (35%), Positives = 42/85 (49%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
IIAS+ Y W + + E AGA A+ELN+ H G G + + ++ I
Sbjct: 105 IIASLN-GYTAGGWMDFAGELEEAGASAIELNV---HHSGAREYGSSAEIEMTILDSIRD 160
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIA 562
V AI +P FVKL+ N T + IA
Sbjct: 161 -VNSAITVPLFVKLSSNFTSLPHIA 184
>UniRef50_Q7R9R0 Cluster: Uncharacterized protein family UPF0034,
putative; n=7; Plasmodium|Rep: Uncharacterized protein
family UPF0034, putative - Plasmodium yoelii yoelii
Length = 531
Score = 42.3 bits (95), Expect = 0.033
Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 5/86 (5%)
Frame = +2
Query: 320 IMCSYNEEDWTLLSKKA---EAAGADALELNLSCPHGM--GESGMGLACGQDPVLVKGIS 484
I+C D T LS+ A E AG D + +N+ CP + G ++P LVK I
Sbjct: 210 IVCQLGGSDPTSLSEAAILVEQAGYDEININVGCPSTKVANKGAFGAYLMKNPQLVKNIV 269
Query: 485 QWVRKAIKIPFFVKLTPNITDIVSIA 562
++K ++IP VK+ + ++ S +
Sbjct: 270 YEIKKKVQIPVTVKIRTGVDNLDSFS 295
>UniRef50_Q9WYG8 Cluster: Dihydroorotate dehydrogenase; n=4;
Thermotogaceae|Rep: Dihydroorotate dehydrogenase -
Thermotoga maritima
Length = 270
Score = 42.3 bits (95), Expect = 0.033
Identities = 43/158 (27%), Positives = 68/158 (43%), Gaps = 2/158 (1%)
Frame = +2
Query: 389 ALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFV-KLTPNITDIVSIAV 565
A+E N SCP+ + E G+ + + K + +RK + F + K+ + A
Sbjct: 110 AVEFNFSCPN-VKEGGLSIVKNAEEW--KKLLNTLRKELPDSFLIAKVGVEGIFVEDAAE 166
Query: 566 AAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTY-GGLSGNATRPMGLRAVSAI 742
+ G G++ +NTV GL EK T GGLSG +P+ LRAV +
Sbjct: 167 FVMKTGWDGITLVNTVRGLHF-------------EKDTMILGGLSGPVLKPIALRAVYEV 213
Query: 743 GNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAV 856
R S + A +F+ GA V+ + SA+
Sbjct: 214 KKRFPELFVIASGGVYSVKDAEEFLKVGADVIGVGSAL 251
>UniRef50_A7H8H3 Cluster: Dihydroorotate dehydrogenase; n=2;
Anaeromyxobacter|Rep: Dihydroorotate dehydrogenase -
Anaeromyxobacter sp. Fw109-5
Length = 328
Score = 41.5 bits (93), Expect = 0.057
Identities = 30/100 (30%), Positives = 49/100 (49%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
+IAS+ C+ WT ++ E AGADALE+NL E+ ++ + +
Sbjct: 102 VIASLNCAA-PGSWTDYARDIEQAGADALEVNLYSV----EADPTVSGAEVEARYLEVVA 156
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAIN 607
VR+A++IP VKL+P + + A G +G+ N
Sbjct: 157 AVRQAVRIPIAVKLSPFFSSLAHFATRLDGLGVNGLVLFN 196
>UniRef50_Q5PBF6 Cluster: Dihydroorotate dehydrogenase; n=12;
Rickettsiales|Rep: Dihydroorotate dehydrogenase -
Anaplasma marginale (strain St. Maries)
Length = 389
Score = 41.1 bits (92), Expect = 0.075
Identities = 44/168 (26%), Positives = 72/168 (42%), Gaps = 5/168 (2%)
Frame = +2
Query: 392 LELNLSCPHGMGESGMGLACGQDPVL--VKGISQWVRKAIKIPFFVKLTPNITDIV--SI 559
+ +N+S P+ G + +L V+ + V +A +P F+K+ P+I+D + I
Sbjct: 202 ITINVSSPNTAGLRDLQNRGPLSEILSSVRDARRSVDQAESVPIFLKIAPDISDELKQDI 261
Query: 560 AVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSA 739
A + SG+ NT + L + D R K T GGLSG + +S
Sbjct: 262 AEEIVKHKISGLIVSNTTTDLSLLGKD--------RNKSITQGGLSGRPLFDLSTTVLSE 313
Query: 740 IGN-RXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAVQNQDFTVV 880
+ + S ALQ I GA +VQ+ +A+ + F VV
Sbjct: 314 MYSLLRDKVILIGCGGVSSGAQALQKIKAGASLVQLYTALVYEGFGVV 361
>UniRef50_A6GHV6 Cluster: Dihydrouridine synthase family protein;
n=1; Plesiocystis pacifica SIR-1|Rep: Dihydrouridine
synthase family protein - Plesiocystis pacifica SIR-1
Length = 321
Score = 40.7 bits (91), Expect = 0.099
Identities = 29/83 (34%), Positives = 44/83 (53%), Gaps = 6/83 (7%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQWVRKAI--KIPFFVKL 529
++ A A GA ++LN CP + S G +DP V+ +++ VR A+ ++P VK+
Sbjct: 78 AETAVALGAPGIDLNFGCPAKTVNSSDGGATLLKDPCRVEAVTRAVRAAVPAELPVTVKI 137
Query: 530 TPNITD---IVSIAVAAYEGGAS 589
D +V IA AA GGAS
Sbjct: 138 RVGWEDPSPVVEIARAAEAGGAS 160
>UniRef50_Q44RR4 Cluster: Dihydroorotate dehydrogenase; n=5;
Chlorobiaceae|Rep: Dihydroorotate dehydrogenase -
Chlorobium limicola DSM 245
Length = 405
Score = 40.3 bits (90), Expect = 0.13
Identities = 24/100 (24%), Positives = 49/100 (49%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
+IASI C ++ +W + + E AGAD LE+N+ + S + ++ L + +
Sbjct: 180 VIASINC-VSQGEWLSFASQIERAGADGLEINIF----LSPSDSSRSSTENERLYGDVLE 234
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAIN 607
+ + ++IP K++ + + + AV+ G G+ N
Sbjct: 235 NITRVVRIPVAAKISSYFSSLAAEAVSLSHSGIRGLVLFN 274
>UniRef50_Q7S4R9 Cluster: Putative uncharacterized protein
NCU05753.1; n=2; Sordariomycetes|Rep: Putative
uncharacterized protein NCU05753.1 - Neurospora crassa
Length = 580
Score = 40.3 bits (90), Expect = 0.13
Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 4/78 (5%)
Frame = -2
Query: 801 DSAESIPPIPRIGKPGSLLPIAETARSPI-GRVALPDSPPYVVCFSRPTAGHGVPSALID 625
D A PP P+ G P + PI + SP A P PP+ RPT+ HG P A
Sbjct: 204 DGARPPPPPPKPGAPAAAAPIPQHQPSPAPSYAAAPPVPPHPPHPGRPTSQHGGPGASTT 263
Query: 624 INP---DTVFIADTPLAP 580
+P + + A PL P
Sbjct: 264 QSPRPGPSRYDAPPPLPP 281
>UniRef50_Q8YVR2 Cluster: Alr1912 protein; n=9; Bacteria|Rep:
Alr1912 protein - Anabaena sp. (strain PCC 7120)
Length = 343
Score = 39.9 bits (89), Expect = 0.17
Identities = 31/100 (31%), Positives = 50/100 (50%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQ 487
IIAS+ S + + WT ++ E AGA ALELN H E L Q + +
Sbjct: 104 IIASLNGS-SLDGWTEYARMIEQAGAAALELNTYSVHTDPE----LTSEQIEQSYINMLK 158
Query: 488 WVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAIN 607
V+ +++IP +KL+P T++ ++A + GA + N
Sbjct: 159 VVKASVQIPVAIKLSPYFTNMANMAKRLDDAGADALVLFN 198
>UniRef50_Q5ZRM0 Cluster: Nitrogen regulation protein; n=4;
Legionella pneumophila|Rep: Nitrogen regulation protein
- Legionella pneumophila subsp. pneumophila (strain
Philadelphia 1 /ATCC 33152 / DSM 7513)
Length = 329
Score = 39.9 bits (89), Expect = 0.17
Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 10/132 (7%)
Frame = +2
Query: 164 RIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVTELKKDF---------PNKVIIA 316
R+++G +G + P + F NI C + C ++ L K P + +A
Sbjct: 20 RLIQGPLAGYSCAPFRDLF-NIYTPPAYCVSEMCSAIDILHKHSSQSRYIYRAPTEKFLA 78
Query: 317 SIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHG-MGESGMGLACGQDPVLVKGISQWV 493
+ + K ++ GAD +++N CP + + G G A +DP + I V
Sbjct: 79 YQISGNEPHVLAEAAAKLQSLGADLIDINCGCPKSKIRKKGAGSALLEDPQKLIAIISRV 138
Query: 494 RKAIKIPFFVKL 529
R AI IP +K+
Sbjct: 139 RAAISIPLTIKI 150
>UniRef50_Q2RTR9 Cluster: Dihydrouridine synthase TIM-barrel protein
nifR3; n=1; Rhodospirillum rubrum ATCC 11170|Rep:
Dihydrouridine synthase TIM-barrel protein nifR3 -
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Length = 362
Score = 39.5 bits (88), Expect = 0.23
Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCPHGMGESGM-GLACGQDPVLVKGISQWVRKAIKIPFFVKLTP 535
+++ E AGA+ +++N+ CP G+ G A +D L I + V A+ +P +K+
Sbjct: 89 ARRVEGAGAELIDINMGCPVRKVVGGLGGSALMRDLPLAARILEAVVGAVTLPVSLKMRL 148
Query: 536 NITDIVSIAV-AAYEGGASGVSAINTVSGLMSIRADG-TPWPAVGREK 673
D AV A ++G+S + + DG WPA+G K
Sbjct: 149 GWDDASRNAVELARLAESAGISRLTVHGRTRAQMYDGRADWPAIGLVK 196
>UniRef50_Q0B0N8 Cluster: Putative TIM-barrel protein, NifR3 family;
n=2; Clostridiales|Rep: Putative TIM-barrel protein,
NifR3 family - Syntrophomonas wolfei subsp. wolfei
(strain Goettingen)
Length = 318
Score = 39.5 bits (88), Expect = 0.23
Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 1/101 (0%)
Frame = +2
Query: 230 ELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLS 409
E++S+K Y +++ K +A + E ++ E GAD +++N+
Sbjct: 41 EMVSDKGLVYGQGRTSKIADSSGEKRPVAVQIFGSEAESMATAARIVEEMGADIIDINMG 100
Query: 410 CP-HGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKL 529
CP + ++G G A D +GI + V + +K+P VK+
Sbjct: 101 CPTPKIVKNGEGAALMLDITKSRGIVREVLRVVKVPVTVKM 141
>UniRef50_Q47C62 Cluster: Dihydroorotate dehydrogenase; n=2;
Betaproteobacteria|Rep: Dihydroorotate dehydrogenase -
Dechloromonas aromatica (strain RCB)
Length = 336
Score = 38.3 bits (85), Expect = 0.53
Identities = 59/251 (23%), Positives = 98/251 (39%)
Frame = +2
Query: 104 GFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSVTEL 283
G A SL ++ V + I R + + +G G + ++Y + + L
Sbjct: 38 GAAAIVMHSLFEEDVRHDEQMIDRFLVHPDTFGEATGHLPFGHDYQSRLDSY-LEQIQRL 96
Query: 284 KKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDP 463
K V+ AS+ S + W L K+ + AGADALELN S ++C
Sbjct: 97 KSRLAIPVV-ASLNGS-SLSGWVELGKEMQGAGADALELNA----WYMPSDPKISCEAIE 150
Query: 464 VLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMSIRADG 643
+ Q ++ + IP +KL+P + + GA+G+S N D
Sbjct: 151 DHHVSLLQELKTVVSIPVSMKLSPFFSSLPHFVHQIEMAGAAGISLFNR---FFQPDIDL 207
Query: 644 TPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXXXDSAESALQFIMC 823
V R + LS +A + +R + AI +AE AL+ ++
Sbjct: 208 ETLSVVDRVQ------LSSSADTLLAMRWI-AILRGSTKLSLAATGGVHTAEDALKMLLA 260
Query: 824 GAPVVQICSAV 856
GA V + SA+
Sbjct: 261 GADVAHMASAL 271
>UniRef50_UPI000023EA9A Cluster: hypothetical protein FG07217.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG07217.1 - Gibberella zeae PH-1
Length = 510
Score = 37.5 bits (83), Expect = 0.93
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Frame = +2
Query: 335 NEEDWTLLSKKAEAAGADALELNLSCPHGMGESG-MGLACGQDPVLVKGISQWVRKAIKI 511
N+ D L + K A DA++LNL CP G+ G G +D L+ + + K + +
Sbjct: 111 NDPDALLSAAKQVAPYCDAVDLNLGCPQGIARKGKYGAFLQEDQDLIFRLINILHKELPV 170
Query: 512 PFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSG 619
P K+ I D +A + ++I TV G
Sbjct: 171 PVTAKI--RILDTKEETLAYAQNVLKAGASILTVHG 204
>UniRef50_A6U9Y2 Cluster: Dihydrouridine synthase DuS; n=2;
Sinorhizobium|Rep: Dihydrouridine synthase DuS -
Sinorhizobium medicae WSM419
Length = 385
Score = 37.5 bits (83), Expect = 0.93
Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Frame = +2
Query: 371 EAAGADALELNLSCPHGMGESGMGLAC-GQDPVLVKGISQWVRKAIKIPFFVKLTPNITD 547
EA G D + +N+ CP +SG AC Q+P LV ++ A++IP VK + D
Sbjct: 96 EAYGYDEINMNVGCPSDRVQSGTFGACLMQEPALVADCIAAMKAAVEIPVTVKCRIGVDD 155
>UniRef50_A6SLQ0 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 342
Score = 37.5 bits (83), Expect = 0.93
Identities = 35/126 (27%), Positives = 58/126 (46%), Gaps = 9/126 (7%)
Frame = +2
Query: 392 LELNLSCPHGMGESGM---GLACGQDPVLVK----GISQWVRKAIKIPFFVKLTPNITDI 550
+E+NLSCP+ +G+ G A ++K G + + IK P + + ++
Sbjct: 155 MEINLSCPNIVGKPPPAYDGEAMASYIKVIKRMKTGTTNRIHVGIKTPPYT-YSEQFKNL 213
Query: 551 VS-IAVAAYEGGASGVSAINTVSGLMS-IRADGTPWPAVGREKHTTYGGLSGNATRPMGL 724
VS + A G + +S I T + L S + D PA+G GG++G+A P+ L
Sbjct: 214 VSALEFGALPSGENAISFITTTNTLGSCLIVDDLGNPALGSSNGEGIGGMAGDALHPIAL 273
Query: 725 RAVSAI 742
V I
Sbjct: 274 GNVKTI 279
>UniRef50_Q4AFB1 Cluster: Putative uncharacterized protein; n=1;
Chlorobium phaeobacteroides BS1|Rep: Putative
uncharacterized protein - Chlorobium phaeobacteroides
BS1
Length = 220
Score = 37.1 bits (82), Expect = 1.2
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Frame = +2
Query: 359 SKKAEAAGADALELNL-SCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTP 535
+KK E AGADALELN + P G + ++ ++G V K +KIP VKL+P
Sbjct: 3 AKKLEEAGADALELNFYNNPRDFDMEGRSI-LNEELDTIEG----VMKEVKIPVSVKLSP 57
Query: 536 NITDIVSIAVAAYEGGASGVSAIN 607
T+ + + GA+G N
Sbjct: 58 FYTNPLYAINEMDKKGANGFVLFN 81
>UniRef50_A5EVV4 Cluster: Dihydrouridine synthase; n=1;
Dichelobacter nodosus VCS1703A|Rep: Dihydrouridine
synthase - Dichelobacter nodosus (strain VCS1703A)
Length = 318
Score = 37.1 bits (82), Expect = 1.2
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 3/107 (2%)
Frame = +2
Query: 371 EAAGADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITD 547
+A G D +++N+ CP +G+ G A D V+ I V + + IP +K +
Sbjct: 90 QALGCDVIDINMGCPAKKVGKQNAGSALLSDLPQVEKILAQVTRVVSIPVTLKTRLGFNE 149
Query: 548 -IVSIAVAAYEGGASGVSAINTVSGLMSIRADGTP-WPAVGREKHTT 682
++I A +GV+A+ + R +GT + +GR K T
Sbjct: 150 QTMTIETVAKIAENTGVAALTVHGRTRAQRFNGTAHYDEIGRVKAQT 196
>UniRef50_Q3AZ67 Cluster: Dihydrouridine synthase TIM-barrel protein
nifR3; n=20; Cyanobacteria|Rep: Dihydrouridine synthase
TIM-barrel protein nifR3 - Synechococcus sp. (strain
CC9902)
Length = 356
Score = 36.7 bits (81), Expect = 1.6
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVK 526
+++AE AGA +++N+ CP + + G G +DP L I + V A+ IP VK
Sbjct: 110 ARRAEQAGAFLIDINMGCPVRKIAKKGGGSGLIRDPNLATQILEAVVDAVSIPVTVK 166
>UniRef50_Q7JP75 Cluster: Cytokinesis defect protein 1, isoform b;
n=6; cellular organisms|Rep: Cytokinesis defect protein
1, isoform b - Caenorhabditis elegans
Length = 1437
Score = 36.7 bits (81), Expect = 1.6
Identities = 14/29 (48%), Positives = 14/29 (48%)
Frame = +1
Query: 1396 GPPPXXXXXGNAXPXXKPPPPGXFXXXPP 1482
GPPP G P PPPPG F PP
Sbjct: 757 GPPPPPPPPGGCPPPPPPPPPGGFKGGPP 785
>UniRef50_Q22A31 Cluster: TIM-barrel protein, yjbN family; n=1;
Tetrahymena thermophila SB210|Rep: TIM-barrel protein,
yjbN family - Tetrahymena thermophila SB210
Length = 480
Score = 36.7 bits (81), Expect = 1.6
Identities = 28/105 (26%), Positives = 49/105 (46%), Gaps = 1/105 (0%)
Frame = +2
Query: 215 SFLNIELISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADAL 394
S L E+I E+ + + E + P + + + + ++ +K E G D +
Sbjct: 128 SILYTEMIHEQAVHHNIRGPQEFLRFDPVQHPVVIQLGGNDPDNLAKAAKICEEIGYDEV 187
Query: 395 ELNLSCPHGMGESGMGLAC-GQDPVLVKGISQWVRKAIKIPFFVK 526
LN+ CP +SG AC ++P LV I + +++A IP VK
Sbjct: 188 NLNVGCPSDRVQSGKFGACLMKEPELVAEIMRKMKEACSIPVTVK 232
>UniRef50_Q7UBC5 Cluster: tRNA-dihydrouridine synthase A; n=231;
Bacteria|Rep: tRNA-dihydrouridine synthase A - Shigella
flexneri
Length = 330
Score = 36.7 bits (81), Expect = 1.6
Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCPHGMGESGMGLACGQ-DPVLVKGISQWVRKAIKIPFFVKLTP 535
+K AEA G D + LN+ CP ++GM AC + LV + +R + IP VK
Sbjct: 82 AKLAEARGYDEINLNVGCPSDRVQNGMFGACLMGNAQLVADCVKAMRDVVSIPVTVKTRI 141
Query: 536 NITD 547
I D
Sbjct: 142 GIDD 145
>UniRef50_Q2W4R2 Cluster: Dihydroorotate dehydrogenase; n=2;
Magnetospirillum|Rep: Dihydroorotate dehydrogenase -
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Length = 329
Score = 36.3 bits (80), Expect = 2.1
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 1/88 (1%)
Frame = +2
Query: 347 WTLLSKKAEAAGADALELNL-SCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFV 523
WT + +++ AGA A+ELN+ P M SG + +L + V+ A+ IP +
Sbjct: 113 WTEYAAQSQQAGASAIELNVYLLPTDMDMSGTEVESRYLEIL-----EDVKSAVSIPVSM 167
Query: 524 KLTPNITDIVSIAVAAYEGGASGVSAIN 607
KL+P + + ++ + G GV N
Sbjct: 168 KLSPYFSSVGNMVKVLDDHGVDGVVLFN 195
>UniRef50_Q6AQ75 Cluster: Related to dihydroorotate dehydrogenase;
n=1; Desulfotalea psychrophila|Rep: Related to
dihydroorotate dehydrogenase - Desulfotalea psychrophila
Length = 329
Score = 35.9 bits (79), Expect = 2.8
Identities = 16/34 (47%), Positives = 24/34 (70%)
Frame = +2
Query: 308 IIASIMCSYNEEDWTLLSKKAEAAGADALELNLS 409
+IAS+ C + +WT + + E AGADA+ELN+S
Sbjct: 103 VIASLNC-VSANEWTSFATQIEKAGADAIELNIS 135
>UniRef50_A7SLQ1 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1027
Score = 35.9 bits (79), Expect = 2.8
Identities = 15/36 (41%), Positives = 15/36 (41%)
Frame = +1
Query: 1399 PPPXXXXXGNAXPXXKPPPPGXFXXXPPXXXXQPNP 1506
PPP G A P PPPPG PP P P
Sbjct: 430 PPPPPPGMGGAPPPPPPPPPGMGGGPPPPPPPPPGP 465
Score = 34.3 bits (75), Expect = 8.6
Identities = 15/39 (38%), Positives = 15/39 (38%)
Frame = +1
Query: 1384 FXKXGPPPXXXXXGNAXPXXKPPPPGXFXXXPPXXXXQP 1500
F GPPP G P PPPPG PP P
Sbjct: 411 FYFSGPPPPPPPPGGVPPPPPPPPPGMGGAPPPPPPPPP 449
>UniRef50_P53759 Cluster: tRNA-dihydrouridine synthase 1; n=11;
Saccharomycetales|Rep: tRNA-dihydrouridine synthase 1 -
Saccharomyces cerevisiae (Baker's yeast)
Length = 423
Score = 35.9 bits (79), Expect = 2.8
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Frame = +2
Query: 335 NEEDWTLLSKKAEAAGADALELNLSCPHGMGESG-MGLACGQDPVLVKGISQWVRKAIKI 511
N+ ++ L + K DA++LNL CP G+ + G G ++ L+ + + K +K+
Sbjct: 96 NDPEYLLAAAKLVEDKCDAVDLNLGCPQGIAKKGHYGSFLMEEWDLIHNLINTLHKNLKV 155
Query: 512 PFFVKL 529
P K+
Sbjct: 156 PVTAKI 161
>UniRef50_Q9A7I4 Cluster: Nitrogen regulation protein Nifr3; n=2;
Caulobacter|Rep: Nitrogen regulation protein Nifr3 -
Caulobacter crescentus (Caulobacter vibrioides)
Length = 315
Score = 35.5 bits (78), Expect = 3.7
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCPHGMGESGMGLACG----QDPVLVKGISQWVRKAIKIPFFVK 526
++ A+ AGA+ ++LN CP E G ACG ++P L + + +A+ +P VK
Sbjct: 67 ARMAQEAGAEIIDLNFGCP--AKEVAAGAACGSALMREPDLAEALVAAAVEAVDVPVTVK 124
Query: 527 LTPN-ITDIVSIAVAAYEGGASGVSAINTVSG 619
+ D ++ A A+G A+ TV G
Sbjct: 125 MRLGWDIDCLNAPDIARRAEAAGAKAV-TVHG 155
>UniRef50_Q6D5J4 Cluster: Putative bifunctional enzyme including
aminotransferase and chitin synthase; n=1;
Pectobacterium atrosepticum|Rep: Putative bifunctional
enzyme including aminotransferase and chitin synthase -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 1026
Score = 35.5 bits (78), Expect = 3.7
Identities = 21/62 (33%), Positives = 29/62 (46%)
Frame = -2
Query: 618 PDTVFIADTPLAPPSYAATAMLTMSVIFGVSFTKNGILIALRTHCDMPFTKTGSCPQARP 439
P+T ++ A + A +L+ SV G S TK L LR H MPF CP +
Sbjct: 591 PNTQWMFVIQCASTFFCARIILSSSVSIGASITKR--LRTLRKHTPMPFVDRVECPVSTS 648
Query: 438 IP 433
+P
Sbjct: 649 LP 650
>UniRef50_A7HBZ7 Cluster: Homocysteine S-methyltransferase; n=2;
Anaeromyxobacter|Rep: Homocysteine S-methyltransferase -
Anaeromyxobacter sp. Fw109-5
Length = 280
Score = 35.5 bits (78), Expect = 3.7
Identities = 25/110 (22%), Positives = 45/110 (40%), Gaps = 6/110 (5%)
Frame = +2
Query: 347 WTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVK 526
+T L A + ++E L +G S +G+ CG + ++ W + + +PF K
Sbjct: 169 FTALGDGATLSDGTSVEEALLAMASLGASAVGVNCGAPGAALGALAAWAKATLPVPFVAK 228
Query: 527 LTPNITDIV----SIAVAAYEGGASGVSAINTVSGLMS--IRADGTPWPA 658
+P + V + A A+GV+ + G +RA W A
Sbjct: 229 PSPGLPGAVRSPDAFAAELRPALAAGVALVGGCCGASGDHLRALAAGWRA 278
>UniRef50_Q1GVC1 Cluster: Dihydroorotate dehydrogenase; n=10;
Alphaproteobacteria|Rep: Dihydroorotate dehydrogenase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 356
Score = 35.1 bits (77), Expect = 4.9
Identities = 46/169 (27%), Positives = 67/169 (39%), Gaps = 6/169 (3%)
Frame = +2
Query: 368 AEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNI-- 541
A A AD L +N+S P+ G + G L+ G++ P F+K+ P++
Sbjct: 167 AMAPLADYLTVNISSPNTPGLRALQDR-GALEALLDGVAAAQPAGAAKPVFLKVAPDLEP 225
Query: 542 TDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMG 721
DI I A + G + V NT P + GGLSG +
Sbjct: 226 ADIDDIVAVALDRGLAAVIVSNTTVAR----------PPLASRHAVEAGGLSGAPLAQLA 275
Query: 722 LRAV----SAIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQICSAV 856
L+ V +A G R SAE A + I GA +VQ+ SA+
Sbjct: 276 LQCVQDFRAASGGRLPLIAAGGIA---SAEQAWERIRAGASLVQVYSAM 321
>UniRef50_A1AT39 Cluster: Dihydrouridine synthase, DuS; n=7;
Desulfuromonadales|Rep: Dihydrouridine synthase, DuS -
Pelobacter propionicus (strain DSM 2379)
Length = 342
Score = 35.1 bits (77), Expect = 4.9
Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCPHGMGESGM-GLACGQDPVLVKGISQWVRKAIKIPFFVKL 529
S+ A+ AGA + LN+ CP+G SG G + P + I +RK I+ F +KL
Sbjct: 111 SQAAQDAGAAHINLNMGCPYGRMTSGQTGGGMLRSPQELSSIIPALRKTIRGTFSIKL 168
>UniRef50_Q9FH91 Cluster: Gb|AAF51525.1; n=6; Magnoliophyta|Rep:
Gb|AAF51525.1 - Arabidopsis thaliana (Mouse-ear cress)
Length = 423
Score = 35.1 bits (77), Expect = 4.9
Identities = 30/121 (24%), Positives = 52/121 (42%), Gaps = 3/121 (2%)
Frame = +2
Query: 236 ISEKCEAYWCQSVTELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCP 415
I + E Y Q T K+D P V + N+ D L + K D +++NL CP
Sbjct: 124 IFTETEKYRNQEFTTCKEDRPLFVQFCA-----NDPDTLLEAAKRVEPYCDYVDINLGCP 178
Query: 416 HGMGESG-MGLACGQDPVLVKGISQWVRKAIKIPFF--VKLTPNITDIVSIAVAAYEGGA 586
+ G G + LVK + + + + + +P +++ PN+ D + A + G
Sbjct: 179 QRIARRGNYGAFLMDNLPLVKSLVEKLAQNLNVPVSCKIRIFPNLEDTLKYAKMLEDAGC 238
Query: 587 S 589
S
Sbjct: 239 S 239
>UniRef50_A4S604 Cluster: Predicted protein; n=1; Ostreococcus
lucimarinus CCE9901|Rep: Predicted protein -
Ostreococcus lucimarinus CCE9901
Length = 287
Score = 35.1 bits (77), Expect = 4.9
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 2/77 (2%)
Frame = +2
Query: 380 GADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVS 556
GAD ++LN CP H + G+G A + P ++ + + + I +P VK+ I D S
Sbjct: 86 GADFVDLNCGCPIHETWKRGLGAALLKKPAKLERLVEGIASRIDVPLTVKIRLGI-DSSS 144
Query: 557 IAVAAYEG-GASGVSAI 604
A EG +G SA+
Sbjct: 145 QARRIAEGLENAGASAV 161
>UniRef50_A2YPF0 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (indica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. indica
(Rice)
Length = 109
Score = 35.1 bits (77), Expect = 4.9
Identities = 19/47 (40%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Frame = +2
Query: 578 GGASGVSAINTVSGLMSIRADGT--PWPAVGREKHTTYGGLSGNATR 712
GG G SG R + PWPA GR + GG+SGNA R
Sbjct: 40 GGGVGADDAEGGSGQSRPRRSSSRPPWPAAGRPEAAAAGGISGNAPR 86
>UniRef50_A6C020 Cluster: Putative uncharacterized protein; n=1;
Planctomyces maris DSM 8797|Rep: Putative
uncharacterized protein - Planctomyces maris DSM 8797
Length = 641
Score = 34.7 bits (76), Expect = 6.5
Identities = 16/58 (27%), Positives = 34/58 (58%)
Frame = +2
Query: 455 QDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAINTVSGLMS 628
+DPV +KG+S++V +A K+ + N D+++++ A A+G + +G+M+
Sbjct: 153 KDPVALKGLSRFVEEANKLTPKPRFVVNSGDLLNLSKALLSSPANGRAGFQNYTGIMN 210
>UniRef50_A0X038 Cluster: Metallophosphoesterase precursor; n=1;
Shewanella pealeana ATCC 700345|Rep:
Metallophosphoesterase precursor - Shewanella pealeana
ATCC 700345
Length = 716
Score = 34.7 bits (76), Expect = 6.5
Identities = 28/114 (24%), Positives = 50/114 (43%)
Frame = +2
Query: 95 QGWGFAVTKTFSLDKDMVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSV 274
+ W TK+ S + ++ N S RI+ + + E+ G +I I +++ Q V
Sbjct: 354 ESWSVDHTKSTSKLRSLIPNSSNRIIEDLVADEHQGTIDYMSTSIASIDVNMNSFFPQVV 413
Query: 275 TELKKDFPNKVIIASIMCSYNEEDWTLLSKKAEAAGADALELNLSCPHGMGESG 436
+L N+ + +M W + A AA DA+ L++S P G +G
Sbjct: 414 PDLSIQVVNEAQLHQLM------KWKEAGEFANAAD-DAIFLSVSAPFKSGRNG 460
>UniRef50_Q8TEK3 Cluster: Histone-lysine N-methyltransferase, H3
lysine-79 specific; n=25; Eumetazoa|Rep: Histone-lysine
N-methyltransferase, H3 lysine-79 specific - Homo sapiens
(Human)
Length = 1739
Score = 34.7 bits (76), Expect = 6.5
Identities = 25/77 (32%), Positives = 30/77 (38%)
Frame = -2
Query: 798 SAESIPPIPRIGKPGSLLPIAETARSPIGRVALPDSPPYVVCFSRPTAGHGVPSALIDIN 619
S E+ PP P P L P A RSP G L PP P A P L+ N
Sbjct: 1587 SVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHAPPP-------PNAALPPPPTLLASN 1639
Query: 618 PDTVFIADTPLAPPSYA 568
P+ + PP+ A
Sbjct: 1640 PEPALLQSLASLPPNQA 1656
>UniRef50_Q9Z7D8 Cluster: Predicted oxidoreductase; n=7;
Chlamydiaceae|Rep: Predicted oxidoreductase - Chlamydia
pneumoniae (Chlamydophila pneumoniae)
Length = 335
Score = 34.3 bits (75), Expect = 8.6
Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Frame = +2
Query: 311 IASIMCSYNEEDWTLLSKKAEAAGADALELNLSCP-HGMGESGMGLACGQDPVLVKGISQ 487
I + +C N E +K E G D ++LN CP + + G G + P L+ I
Sbjct: 71 IGAQLCGSNPETSGEAAKILEGLGFDLIDLNCGCPTDKITKDGSGSGLLKTPELIGRILD 130
Query: 488 WVRKAIKIPFFVKL 529
+ ++ IP VK+
Sbjct: 131 KIINSVSIPVTVKI 144
>UniRef50_Q8EYC6 Cluster: Dihydroorotate dehydrogenase; n=4;
Leptospira|Rep: Dihydroorotate dehydrogenase -
Leptospira interrogans
Length = 382
Score = 34.3 bits (75), Expect = 8.6
Identities = 44/171 (25%), Positives = 71/171 (41%), Gaps = 3/171 (1%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAIKIPFF 520
ED+ KK AD +N+S P+ G L++GI + + K KIP F
Sbjct: 177 EDYVYTLKKLSPY-ADYAVINISSPNTPGLRNFQKQ-ENFVSLIQGIRKDLGKNFKIPLF 234
Query: 521 VKLTPNI--TDIVSIAVAAYEGGASGVSAINTVSGLMSIRADGTPWPAVGREKHTTYGGL 694
VK P++ ++ ++ + +GV NT ++ +P V +E GGL
Sbjct: 235 VKFAPDMETKELEALLETSLSLKINGVVLTNTTIDKSCLK----NYPNVEKE-----GGL 285
Query: 695 SGNATRPMGLRAVS-AIGNRXXXXXXXXXXXXDSAESALQFIMCGAPVVQI 844
SG + V A DS ++AL+ I+ GA ++QI
Sbjct: 286 SGTPLKNRSTEFVRIAYRILKRRIPIIGVGGIDSEKTALEKILAGADLIQI 336
>UniRef50_Q30WR3 Cluster: Dihydrouridine synthase family protein;
n=3; Desulfovibrio|Rep: Dihydrouridine synthase family
protein - Desulfovibrio desulfuricans (strain G20)
Length = 376
Score = 34.3 bits (75), Expect = 8.6
Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 5/90 (5%)
Frame = +2
Query: 341 EDWTLLSKKAEAAGADALELNLSCPHG-MGESGMGLACGQDPVLVKGISQWVRKAIKIPF 517
+D +++ E+ G +++N+ C + + G G +DP + VR+A+ +P
Sbjct: 126 QDMAAAARRVESEGFFGVDINMGCSVAPIVKKGCGADLLRDPERAVRMVDAVRRAVSVPV 185
Query: 518 FVKL----TPNITDIVSIAVAAYEGGASGV 595
FVK+ +P+ V++A + GA +
Sbjct: 186 FVKMRTGWSPDPEPAVNLARRLQDAGADAL 215
>UniRef50_Q1IVR5 Cluster: Dihydrouridine synthase TIM-barrel protein
nifR3; n=2; Acidobacteria|Rep: Dihydrouridine synthase
TIM-barrel protein nifR3 - Acidobacteria bacterium
(strain Ellin345)
Length = 370
Score = 34.3 bits (75), Expect = 8.6
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Frame = +2
Query: 359 SKKAEAAGADALELNLSCPHG-MGESGMGLACGQDPVLVKGISQWVRKAIKIPFFVK 526
+K + G D ++LNL CP + + G +D +K I + VRKA+ IPF VK
Sbjct: 107 AKVVQDLGFDLVDLNLGCPSKRVVKCNGGSGLLRDLPQIKVIFESVRKAVTIPFTVK 163
>UniRef50_A5URC7 Cluster: Dihydroorotate dehydrogenase family
protein; n=2; Roseiflexus|Rep: Dihydroorotate
dehydrogenase family protein - Roseiflexus sp. RS-1
Length = 264
Score = 34.3 bits (75), Expect = 8.6
Identities = 38/152 (25%), Positives = 58/152 (38%)
Frame = +2
Query: 425 GESGMGLACGQDPVLVKGISQWVRKAIKIPFFVKLTPNITDIVSIAVAAYEGGASGVSAI 604
G +G+ + G D VR +P VKL P ++++A + + GA ++
Sbjct: 119 GIAGLEITFGDDLTAAARTVAAVRAVTLLPLLVKL-PLHDRLIAVARSIIDAGADALTIA 177
Query: 605 NTVSGLMSIRADGTPWPAVGREKHTTYGGLSGNATRPMGLRAVSAIGNRXXXXXXXXXXX 784
P P G H G LSG A RP+ L A++ +
Sbjct: 178 FPPHAC-------APDPHTGELLH---GRLSGPAIRPLVLAAIADVCT-TTHVPVVACGG 226
Query: 785 XDSAESALQFIMCGAPVVQICSAVQNQDFTVV 880
+ E A F+ GA VQ+ SA+ F V
Sbjct: 227 IGTVEDARAFLSAGATAVQVGSALLADPFAAV 258
>UniRef50_A0BLV2 Cluster: Chromosome undetermined scaffold_115, whole
genome shotgun sequence; n=1; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_115, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 1084
Score = 34.3 bits (75), Expect = 8.6
Identities = 14/36 (38%), Positives = 14/36 (38%)
Frame = +1
Query: 1399 PPPXXXXXGNAXPXXKPPPPGXFXXXPPXXXXQPNP 1506
PPP G P PPPPG PP P P
Sbjct: 587 PPPPPPPPGGRLPPPPPPPPGGMPPPPPMPGRAPPP 622
>UniRef50_Q7RX85 Cluster: Putative uncharacterized protein
NCU00065.1; n=3; Pezizomycotina|Rep: Putative
uncharacterized protein NCU00065.1 - Neurospora crassa
Length = 629
Score = 34.3 bits (75), Expect = 8.6
Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Frame = +2
Query: 335 NEEDWTLLSKKAEAAGADALELNLSCPHGMGESGM-GLACGQDPVLVKGISQWVRKAIKI 511
N+ + L + K A DA++LNL CP G+ + G G ++ L+ + + K + I
Sbjct: 144 NDPAYLLSAAKLVAPYCDAVDLNLGCPQGIAKRGQYGSFLQENQELIFELINTLHKELDI 203
Query: 512 PFFVKL 529
P K+
Sbjct: 204 PVTAKI 209
>UniRef50_A6SMP4 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 308
Score = 34.3 bits (75), Expect = 8.6
Identities = 17/48 (35%), Positives = 25/48 (52%)
Frame = -2
Query: 747 LPIAETARSPIGRVALPDSPPYVVCFSRPTAGHGVPSALIDINPDTVF 604
L +AE +P R ++ +PP + S AGH L D+ PDT+F
Sbjct: 239 LALAEAFSAPDHRHSIASTPPTMSSVSDVPAGHNYKLILEDVKPDTLF 286
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 1,279,799,040
Number of Sequences: 1657284
Number of extensions: 26088083
Number of successful extensions: 78949
Number of sequences better than 10.0: 119
Number of HSP's better than 10.0 without gapping: 67890
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 77116
length of database: 575,637,011
effective HSP length: 104
effective length of database: 403,279,475
effective search space used: 163731466850
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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