KWMTBOMO12222

Protein

Length

1,350 amino acids

Protein family membership

Glycoside hydrolase family 1 (IPR001360)

Isoleucine-tRNA ligase (IPR002301)

Domains and repeats

Domain
2 - 408
Glycoside hydrolase superfamily (IPR017853)
Glycoside hydrolase, catalytic domain (IPR013781)
462 - 636
Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
642 - 835
Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain (IPR009008)
839 - 1,077
Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
1,080 - 1,347
Aminoacyl-tRNA synthetase, class Ia, anticodon-binding (IPR009080)
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding (IPR013155)
Isoleucyl tRNA synthetase type 1, anticodon-binding domain (IPR033708)
Domain
480 - 1,075
Aminoacyl-tRNA synthetase, class Ia (IPR002300)

1 200 400 600 800 1000 1200 1350

Detailed signature matches

IPR001360

Glycoside hydrolase family 1
1. PF00232 (Glyco_hydro_1)
  
  4 - 408
  
  Pfam
  PF00232 (Glyco_hydro_1)
IPR002301

Isoleucine-tRNA ligase
1. TIGR00392
  
  460 - 1,227
  
  TIGRFAMs
  TIGR00392 (TIGR00392)
2. PR00984 (TRNASYNTHILE)
  
  834 - 849
  
  PRINTS
  PR00984 (TRNASYNTHILE)
  
  486 - 497
  
  PRINTS
  PR00984 (TRNASYNTHILE)
  
  672 - 695
  
  PRINTS
  PR00984 (TRNASYNTHILE)
  
  964 - 977
  
  PRINTS
  PR00984 (TRNASYNTHILE)
IPR017853

Glycoside hydrolase superfamily
1. SSF51445 ((Trans)gl...)
  
  2 - 408
  
  SUPERFAMILY
  SSF51445 ((Trans)glycosidases)
IPR013781

Glycoside hydrolase, catalytic domain
1. G3DSA:3.20.20.80
  
  2 - 408
  
  GENE3D
  G3DSA:3.20.20.80 (G3DSA:3.20.20.80)
IPR014729

Rossmann-like alpha/beta/alpha sandwich fold
1. G3DSA:3.40.50...
  
  839 - 1,077
  
  GENE3D
  G3DSA:3.40.50.620 (G3DSA:3.40.50.620)
  
  462 - 636
  
  GENE3D
  G3DSA:3.40.50.620 (G3DSA:3.40.50.620)
IPR002300

Aminoacyl-tRNA synthetase, class Ia
1. PF00133 (tRNA-synt_1)
  
  480 - 1,075
  
  Pfam
  PF00133 (tRNA-synt_1)
IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
1. G3DSA:3.90.74...
  
  643 - 824
  
  GENE3D
  G3DSA:3.90.740.10 (G3DSA:3.90.740.10)
2. SSF50677 (ValRS/Ile...)
  
  642 - 835
  
  SUPERFAMILY
  SSF50677 (ValRS/IleRS/LeuRS editing domain)
IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
1. SSF47323 (Anticodon...)
  
  1,094 - 1,347
  
  SUPERFAMILY
  SSF47323 (Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases)
2. G3DSA:1.10.73...
  
  1,085 - 1,218
  
  GENE3D
  G3DSA:1.10.730.10 (G3DSA:1.10.730.10)
IPR013155

Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
1. PF08264 (Anticodon_1)
  
  1,125 - 1,268
  
  Pfam
  PF08264 (Anticodon_1)
IPR033708

Isoleucyl tRNA synthetase type 1, anticodon-binding domain
1. cd07960 (Anticodon_...)
  
  1,080 - 1,253
  
  CDD
  cd07960 (Anticodon_Ia_Ile_BEm)
IPR018120

Glycoside hydrolase family 1, active site
1. PS00572 (GLYCOSYL_H...)
  
  330 - 338
  
  PROSITE patterns
  PS00572 (GLYCOSYL_HYDROL_F1_1)
IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site
1. PS00178 (AA_TRNA_LI...)
  
  493 - 504
  
  PROSITE patterns
  PS00178 (AA_TRNA_LIGASE_I)

no IPR

Unintegrated signatures

SSF52374 (Nucleotid...)

836 - 1,089

SUPERFAMILY
SSF52374 (Nucleotidylyl transferase)

442 - 638

SUPERFAMILY
SSF52374 (Nucleotidylyl transferase)

Residue annotation

tRNA binding surfa...

1,083N

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,087D

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,091E

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,097N

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,100K

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,101Y

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,148N

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,151A

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,152Q

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,155L

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,156N

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,159S

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,164A

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,168H

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,171K

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,251R

tRNA binding surface
1,083N, 1,087D, 1,091E, 1,097N, 1,100K, 1,101Y, 1,148N, 1,151A, 1,152Q, 1,155L, 1,156N, 1,159S, 1,164A, 1,168H, 1,171K, 1,251R
CDD
cd07960 (Anticodon_Ia_Ile_BEm)
anticodon binding ...

1,097N

anticodon binding site
1,097N, 1,100K
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

1,100K

anticodon binding site
1,097N, 1,100K
CDD
cd07960 (Anticodon_Ia_Ile_BEm)

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation

Molecular Function

GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features