KWMTBOMO12019

Protein

Length

356 amino acids

Protein family membership

UDP-glucose 4-epimerase GalE (IPR005886)

Domains and repeats

Domain
1 - 353
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 356

Detailed signature matches

IPR005886

UDP-glucose 4-epimerase GalE
1. TIGR01179
  
  4 - 352
  
  TIGRFAMs
  TIGR01179 (TIGR01179)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  6 - 342
  
  Pfam
  PF16363 (GDP_Man_Dehyd)
2. SSF51735 (NAD(P)-bi...)
  
  1 - 353
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
3. G3DSA:3.40.50...
  
  3 - 195
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

no IPR

Unintegrated signatures

G3DSA:3.90.25.10

196 - 247

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

281 - 354

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
cd05247 (UDP_G4E_1_...)

4 - 347

CDD
cd05247 (UDP_G4E_1_SDR_e)

Residue annotation

NAD binding site c...

9G

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

11A

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

12G

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

13Y

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

14V

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

38D

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

39N

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

40L

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

41S

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

42N

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

43A

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

71V

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

72D

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

73I

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

94F

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

95A

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

96A

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

98K

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

113V

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

136S

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

137S

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

138S

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

164Y

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

168K

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

192Y

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

193F

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)

195P

NAD binding site
9G, 11A, 12G, 13Y, 14V, 38D, 39N, 40L, 41S, 42N, 43A, 71V, 72D, 73I, 94F, 95A, 96A, 98K, 113V, 136S, 137S, 138S, 164Y, 168K, 192Y, 193F, 195P
CDD
cd05247 (UDP_G4E_1_SDR_e)
homodimer interfac...

104V

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

106K

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

107P

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

108L

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

111Y

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

112Q

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

115I

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

116N

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

119C

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

120T

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

122F

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

123E

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

126R

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

163P

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

166K

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

170F

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

173E

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

174I

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

176K

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

177D

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)

178L

homodimer interface
104V, 106K, 107P, 108L, 111Y, 112Q, 115I, 116N, 119C, 120T, 122F, 123E, 126R, 163P, 166K, 170F, 173E, 174I, 176K, 177D, 178L
CDD
cd05247 (UDP_G4E_1_SDR_e)
active site cd05247

114N

active site
114N, 138S, 164Y, 168K
CDD
cd05247 (UDP_G4E_1_SDR_e)

138S

active site
114N, 138S, 164Y, 168K
CDD
cd05247 (UDP_G4E_1_SDR_e)

164Y

active site
114N, 138S, 164Y, 168K
CDD
cd05247 (UDP_G4E_1_SDR_e)

168K

active site
114N, 138S, 164Y, 168K
CDD
cd05247 (UDP_G4E_1_SDR_e)
substrate binding ...

138S

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

139C

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

140T

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

164Y

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

192Y

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

193F

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

194N

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

213N

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

214N

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

215L

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

230L

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

231K

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

232V

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

233F

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

244G

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

246R

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

248Y

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

286V

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

309R

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

312D

substrate binding site
138S, 139C, 140T, 164Y, 192Y, 193F, 194N, 213N, 214N, 215L, 230L, 231K, 232V, 233F, 244G, 246R, 248Y, 286V, 309R, 312D
CDD
cd05247 (UDP_G4E_1_SDR_e)

GO term prediction

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0003978 UDP-glucose 4-epimerase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

KWMTBOMO12019

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component