KWMTBOMO11771

Protein

Length

232 amino acids

Protein family membership

Proteasome, subunit alpha/beta (IPR001353)
- Proteasome B-type subunit (IPR023333)

Domains and repeats

Domain
21 - 232
Nucleophile aminohydrolases, N-terminal (IPR029055)

1 50 100 150 200 232

Detailed signature matches

IPR001353

Proteasome, subunit alpha/beta
1. PF00227 (Proteasome)
  
  26 - 217
  
  Pfam
  PF00227 (Proteasome)
IPR023333

Proteasome B-type subunit
1. PS51476 (PROTEASOME...)
  
  28 - 217
  
  PROSITE profiles
  PS51476 (PROTEASOME_BETA_2)
IPR029055

Nucleophile aminohydrolases, N-terminal
1. G3DSA:3.60.20.10
  
  21 - 232
  
  GENE3D
  G3DSA:3.60.20.10 (G3DSA:3.60.20.10)
2. SSF56235 (N-termina...)
  
  23 - 230
  
  SUPERFAMILY
  SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))

no IPR

Unintegrated signatures

cd03757 (proteasome...)

21 - 232

CDD
cd03757 (proteasome_beta_type_1)

Residue annotation

active site cd03757

29G

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

45D

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

47R

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

61K

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

159S

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

205D

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

208T

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)

209G

active site
29G, 45D, 47R, 61K, 159S, 205D, 208T, 209G
CDD
cd03757 (proteasome_beta_type_1)
beta subunit inter...

47R

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

50T

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

52F

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

53S

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

54I

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

55Y

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

56T

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

57R

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

77W

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

79D

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

94Y

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

106A

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

109Q

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

110M

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

112S

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

113T

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

116Y

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

119R

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

144D

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

146I

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

148H

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

149C

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

150A

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

151R

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

154F

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

162A

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

163Q

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

165Q

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

166P

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

169D

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

170N

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

171Q

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

196D

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

203E

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

204R

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

205D

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

206I

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

209G

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

210D

beta subunit interaction site
47R, 50T, 52F, 53S, 54I, 55Y, 56T, 57R, 77W, 79D, 94Y, 106A, 109Q, 110M, 112S, 113T, 116Y, 119R, 144D, 146I, 148H, 149C, 150A, 151R, 154F, 162A, 163Q, 165Q, 166P, 169D, 170N, 171Q, 196D, 203E, 204R, 205D, 206I, 209G, 210D
CDD
cd03757 (proteasome_beta_type_1)

GO term prediction

Biological Process

GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex

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Entry type

Status

Per-residue features