KWMTBOMO11590

Protein

Length

580 amino acids

Protein family membership

Ku70 (IPR006165)

Domains and repeats

Domain
47 - 226
von Willebrand factor, type A (IPR002035)
427 - 516
Ku70/Ku80 C-terminal arm (IPR005160)
Domain
47 - 186
Ku70/Ku80, N-terminal alpha/beta (IPR005161)
217 - 490
SPOC-like, C-terminal domain (IPR016194)
Domain
223 - 436
Ku70/Ku80 beta-barrel domain (IPR006164)

1 100 200 300 400 500 580

Detailed signature matches

IPR006165

Ku70
1. PIRSF003033 (Ku70)
  
  38 - 580
  
  PIRSF
  PIRSF003033 (Ku70)
2. TIGR00578
  
  53 - 578
  
  TIGRFAMs
  TIGR00578 (TIGR00578)
IPR005161

Ku70/Ku80, N-terminal alpha/beta
1. PF03731 (Ku_N)
  
  47 - 186
  
  Pfam
  PF03731 (Ku_N)
IPR002035

von Willebrand factor, type A
1. SSF53300 (vWA-like)
  
  47 - 193
  
  SUPERFAMILY
  SSF53300 (vWA-like)
2. G3DSA:3.40.50...
  
  51 - 226
  
  GENE3D
  G3DSA:3.40.50.410 (G3DSA:3.40.50.410)
IPR016194

SPOC-like, C-terminal domain
1. G3DSA:2.40.29...
  
  227 - 418
  
  GENE3D
  G3DSA:2.40.290.10 (G3DSA:2.40.290.10)
2. SSF100939 (SPOC dom...)
  
  217 - 490
  
  SUPERFAMILY
  SSF100939 (SPOC domain-like)
IPR006164

Ku70/Ku80 beta-barrel domain
1. PF02735 (Ku)
  
  223 - 436
  
  Pfam
  PF02735 (Ku)
2. SM00559 (ku_4)
  
  282 - 426
  
  SMART
  SM00559 (ku_4)
IPR005160

Ku70/Ku80 C-terminal arm
1. G3DSA:1.10.16...
  
  427 - 491
  
  GENE3D
  G3DSA:1.10.1600.10 (G3DSA:1.10.1600.10)
2. PF03730 (Ku_C)
  
  447 - 516
  
  Pfam
  PF03730 (Ku_C)

no IPR

Unintegrated signatures

cd00788 (KU70)

218 - 484

CDD
cd00788 (KU70)

Residue annotation

DNA binding site c...

218Q

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

235K

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

238K

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

242E

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

245K

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

263T

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

312N

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)

379R

DNA binding site
218Q, 235K, 238K, 242E, 245K, 263T, 312N, 379R
CDD
cd00788 (KU70)
heterodimer interf...

227V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

235K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

238K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

239S

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

240N

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

245K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

246V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

247Y

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

248L

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

249S

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

253N

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

254A

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

259D

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

260T

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

261K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

262T

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

264K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

265V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

266L

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

289E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

290L

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

291L

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

293C

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

294Q

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

295E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

296Y

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

299E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

300I

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

302A

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

303F

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

307E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

311I

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

316G

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

323L

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

325F

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

326K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

333K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

337F

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

345F

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

355T

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

356T

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

364A

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

368T

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

373I

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

375V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

394R

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

405D

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

410P

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

411F

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

412S

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

413E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

414N

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

415V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

416R

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

424D

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

430S

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

431D

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

435D

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

437L

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

444V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

445K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

448Y

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

453F

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

454E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

455N

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

459Q

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

464V

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

466E

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

468K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

480D

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

483K

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

484P

heterodimer interface
227V, 235K, 238K, 239S, 240N, 245K, 246V, 247Y, 248L, 249S, 253N, 254A, 259D, 260T, 261K, 262T, 264K, 265V, 266L, 289E, 290L, 291L, 293C, 294Q, 295E, 296Y, 299E, 300I, 302A, 303F, 307E, 311I, 316G, 323L, 325F, 326K, 333K, 337F, 345F, 355T, 356T, 364A, 368T, 373I, 375V, 394R, 405D, 410P, 411F, 412S, 413E, 414N, 415V, 416R, 424D, 430S, 431D, 435D, 437L, 444V, 445K, 448Y, 453F, 454E, 455N, 459Q, 464V, 466E, 468K, 480D, 483K, 484P
CDD
cd00788 (KU70)

GO term prediction

Biological Process

GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining

Molecular Function

GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0042162 telomeric DNA binding

Cellular Component

GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Entry type

Status

Per-residue features