KWMTBOMO11446

Protein

Length

722 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
4 - 244
NAD(P)-binding domain (IPR016040)
316 - 461
HotDog domain (IPR029069)
448 - 585
HotDog domain (IPR029069)
MaoC-like domain (IPR002539)
606 - 718
SCP2 sterol-binding domain (IPR003033)

1 100 200 300 400 500 600 722

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  10 - 194
  
  Pfam
  PF00106 (adh_short)
2. PR00080 (SDRFAMILY)
  
  89 - 100
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  162 - 181
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  142 - 150
  
  PRINTS
  PR00080 (SDRFAMILY)
3. PR00081 (GDHRDH)
  
  10 - 27
  
  PRINTS
  PR00081 (GDHRDH)
  
  162 - 181
  
  PRINTS
  PR00081 (GDHRDH)
  
  206 - 226
  
  PRINTS
  PR00081 (GDHRDH)
  
  89 - 100
  
  PRINTS
  PR00081 (GDHRDH)
  
  136 - 152
  
  PRINTS
  PR00081 (GDHRDH)
  
  183 - 200
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  4 - 244
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  5 - 242
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR029069

HotDog domain
1. SSF54637 (Thioester...)
  
  468 - 584
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
  
  316 - 461
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
2. G3DSA:3.10.12...
  
  448 - 585
  
  GENE3D
  G3DSA:3.10.129.10 (G3DSA:3.10.129.10)
  
  316 - 447
  
  GENE3D
  G3DSA:3.10.129.10 (G3DSA:3.10.129.10)
IPR002539

MaoC-like domain
1. PF01575 (MaoC_dehyd...)
  
  465 - 582
  
  Pfam
  PF01575 (MaoC_dehydratas)
IPR003033

SCP2 sterol-binding domain
1. G3DSA:3.30.10...
  
  606 - 718
  
  GENE3D
  G3DSA:3.30.1050.10 (G3DSA:3.30.1050.10)
2. SSF55718 (SCP-like)
  
  608 - 717
  
  SUPERFAMILY
  SSF55718 (SCP-like)
3. PF02036 (SCP2)
  
  620 - 717
  
  Pfam
  PF02036 (SCP2)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  149 - 177
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

SM00822 (PKS_KR)

9 - 201

SMART
SM00822 (PKS_KR)
cd03448 (HDE_HSD)

468 - 589

CDD
cd03448 (HDE_HSD)
cd05353 (hydroxyacy...)

4 - 252

CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

Residue annotation

homodimer interfac...

4L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

31R

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

105S

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

106F

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

107T

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

109M

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

110T

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

111E

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

114W

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

115D

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

118Q

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

122L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

123K

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

126F

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

129T

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

130H

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

133W

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

134E

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

150N

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

151A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

152G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

153L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

154F

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

155G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

156N

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

157F

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

158G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

160A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

163S

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

164A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

167L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

168G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

170V

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

171G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

172L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

174N

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

175T

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

176L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

178I

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

179E

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

181A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

182K

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

184N

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

207M

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

210A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

211M

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

215L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

218P

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

219V

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

221A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

222Y

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

223M

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

230D

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

234I

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

235I

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

236D

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

238T

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

239L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

240G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

241F

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

242A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

243T

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

244K

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

245A

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

246Q

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

247L

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

248F

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

249R

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

250S

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

251N

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

252G

homodimer interface
4L, 31R, 105S, 106F, 107T, 109M, 110T, 111E, 114W, 115D, 118Q, 122L, 123K, 126F, 129T, 130H, 133W, 134E, 150N, 151A, 152G, 153L, 154F, 155G, 156N, 157F, 158G, 160A, 163S, 164A, 167L, 168G, 170V, 171G, 172L, 174N, 175T, 176L, 178I, 179E, 181A, 182K, 184N, 207M, 210A, 211M, 215L, 218P, 219V, 221A, 222Y, 223M, 230D, 234I, 235I, 236D, 238T, 239L, 240G, 241F, 242A, 243T, 244K, 245A, 246Q, 247L, 248F, 249R, 250S, 251N, 252G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
NAD binding site c...

15G

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

18G

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

19G

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

20L

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

38N

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

39D

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

40L

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

42S

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

73S

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

74V

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

97N

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

98A

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

99G

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

100I

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

120V

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

121H

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

147T

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

148S

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

149S

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

162Y

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

166K

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

192P

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

193T

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

194A

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

196S

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

197R

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

198L

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

199T

NAD binding site
15G, 18G, 19G, 20L, 38N, 39D, 40L, 42S, 73S, 74V, 97N, 98A, 99G, 100I, 120V, 121H, 147T, 148S, 149S, 162Y, 166K, 192P, 193T, 194A, 196S, 197R, 198L, 199T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
active site cd05353

121H

active site
121H, 149S, 162Y, 166K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

149S

active site
121H, 149S, 162Y, 166K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

162Y

active site
121H, 149S, 162Y, 166K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

166K

active site
121H, 149S, 162Y, 166K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
dimer interaction ...

483D

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)

486A

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)

489R

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)

490M

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)

494L

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)

496P

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)

500D

dimer interaction site
483D, 486A, 489R, 490M, 494L, 496P, 500D
CDD
cd03448 (HDE_HSD)
substrate-binding ...

487L

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

493D

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

495N

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

498H

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

515H

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

517L

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

520L

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

523S

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

527V

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

539V

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

542L

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

544A

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

546F

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

560M

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

569F

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

571T

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

580V

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)

586I

substrate-binding tunnel
487L, 493D, 495N, 498H, 515H, 517L, 520L, 523S, 527V, 539V, 542L, 544A, 546F, 560M, 569F, 571T, 580V, 586I
CDD
cd03448 (HDE_HSD)
active site cd03448

488Y

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

492G

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

493D

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

495N

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

498H

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

513I

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

516G

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)

517L

active site
488Y, 492G, 493D, 495N, 498H, 513I, 516G, 517L
CDD
cd03448 (HDE_HSD)
catalytic site cd0...

493D

catalytic site
493D, 495N, 498H, 516G
CDD
cd03448 (HDE_HSD)

495N

catalytic site
493D, 495N, 498H, 516G
CDD
cd03448 (HDE_HSD)

498H

catalytic site
493D, 495N, 498H, 516G
CDD
cd03448 (HDE_HSD)

516G

catalytic site
493D, 495N, 498H, 516G
CDD
cd03448 (HDE_HSD)
substrate binding ...

524A

substrate binding site
524A, 527V, 537S, 539V
CDD
cd03448 (HDE_HSD)

527V

substrate binding site
524A, 527V, 537S, 539V
CDD
cd03448 (HDE_HSD)

537S

substrate binding site
524A, 527V, 537S, 539V
CDD
cd03448 (HDE_HSD)

539V

substrate binding site
524A, 527V, 537S, 539V
CDD
cd03448 (HDE_HSD)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO11446

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component