KWMTBOMO11354

Protein

Length

512 amino acids

Protein family membership

Aldehyde dehydrogenase NAD(P)-dependent (IPR012394)

Domains and repeats

Domain
9 - 446
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)
Domain
14 - 224
Aldehyde dehydrogenase N-terminal domain (IPR016162)
226 - 422
Aldehyde dehydrogenase, C-terminal (IPR016163)

1 50 100 150 200 250 300 350 400 450 512

Detailed signature matches

IPR012394

Aldehyde dehydrogenase NAD(P)-dependent
1. PIRSF036492 (ALDH)
  
  5 - 488
  
  PIRSF
  PIRSF036492 (ALDH)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  17 - 446
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  9 - 441
  
  Pfam
  PF00171 (Aldedh)
IPR016162

Aldehyde dehydrogenase N-terminal domain
1. G3DSA:3.40.60...
  
  14 - 224
  
  GENE3D
  G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
IPR016163

Aldehyde dehydrogenase, C-terminal
1. G3DSA:3.40.30...
  
  226 - 422
  
  GENE3D
  G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
IPR029510

Aldehyde dehydrogenase, glutamic acid active site
1. PS00687 (ALDEHYDE_D...)
  
  221 - 228
  
  PROSITE patterns
  PS00687 (ALDEHYDE_DEHYDR_GLU)

no IPR

Unintegrated signatures

cd07132 (ALDH_F3AB)

17 - 463

CDD
cd07132 (ALDH_F3AB)

Residue annotation

homodimeric interf...

69M

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

99P

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

100P

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

104V

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

111V

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

115D

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

117Y

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

192R

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

194D

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

202T

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

206R

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

209Y

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

216L

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

236D

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

239V

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

242K

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

243R

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

246W

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

283W

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

293D

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

373E

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

374H

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

378L

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

383N

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

389K

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

392T

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

395T

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

396R

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

397S

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

398G

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

399S

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

400I

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

401S

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

402I

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

403N

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

404D

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

410G

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

415P

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

418G

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

419V

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

421N

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

424I

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

438H

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

440K

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

441S

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

443L

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

444K

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

445K

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

446N

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

447F

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

453K

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

455A

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

456S

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

458R

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

459Y

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

460P

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

461P

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)

462Y

homodimeric interface
69M, 99P, 100P, 104V, 111V, 115D, 117Y, 192R, 194D, 202T, 206R, 209Y, 216L, 236D, 239V, 242K, 243R, 246W, 283W, 293D, 373E, 374H, 378L, 383N, 389K, 392T, 395T, 396R, 397S, 398G, 399S, 400I, 401S, 402I, 403N, 404D, 410G, 415P, 418G, 419V, 421N, 424I, 438H, 440K, 441S, 443L, 444K, 445K, 446N, 447F, 453K, 455A, 456S, 458R, 459Y, 460P, 461P, 462Y
CDD
cd07132 (ALDH_F3AB)
NAD(P) binding sit...

125A

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

126W

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

127N

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

153E

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

182P

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

200G

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

299N

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

301R

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

302H

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

305R

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

348E

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)

350F

NAD(P) binding site
125A, 126W, 127N, 153E, 182P, 200G, 299N, 301R, 302H, 305R, 348E, 350F
CDD
cd07132 (ALDH_F3AB)
catalytic residues...

127N

catalytic residues
127N, 222E, 253G, 256C
CDD
cd07132 (ALDH_F3AB)

222E

catalytic residues
127N, 222E, 253G, 256C
CDD
cd07132 (ALDH_F3AB)

253G

catalytic residues
127N, 222E, 253G, 256C
CDD
cd07132 (ALDH_F3AB)

256C

catalytic residues
127N, 222E, 253G, 256C
CDD
cd07132 (ALDH_F3AB)

GO term prediction

Biological Process

GO:0006081 cellular aldehyde metabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Cellular Component

None predicted.

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Entry type

Status

Per-residue features