KWMTBOMO11239

Protein

Length

544 amino acids

Protein family membership

Major facilitator, sugar transporter-like (IPR005828)

Domains and repeats

Domain
29 - 507
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 500 544

Detailed signature matches

IPR005828

Major facilitator, sugar transporter-like
1. PF00083 (Sugar_tr)
  
  127 - 505
  
  Pfam
  PF00083 (Sugar_tr)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  29 - 502
  
  PROSITE profiles
  PS50850 (MFS)
2. cd06174 (MFS)
  
  117 - 498
  
  CDD
  cd06174 (MFS)
3. SSF103473 (MFS gene...)
  
  127 - 507
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)

no IPR

Unintegrated signatures

G3DSA:1.20.12...

333 - 513

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

127 - 271

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

Residue annotation

putative substrate...

135G

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

138H

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

139C

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

142S

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

146Q

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

147L

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

149Q

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

150G

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

196G

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

197D

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

200S

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

201P

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

203F

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

204M

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

207V

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

219Q

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

220M

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

223L

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

224N

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

230Q

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

343T

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

346N

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

347Y

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

350M

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

351I

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

354V

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

364F

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

368M

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

371D

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

375N

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

422A

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

427A

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

428T

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

431Y

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

435Y

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

436M

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

439S

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

450V

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

451H

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

454C

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

455S

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

458G

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

459R

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

462S

putative substrate translocation pore
135G, 138H, 139C, 142S, 146Q, 147L, 149Q, 150G, 196G, 197D, 200S, 201P, 203F, 204M, 207V, 219Q, 220M, 223L, 224N, 230Q, 343T, 346N, 347Y, 350M, 351I, 354V, 364F, 368M, 371D, 375N, 422A, 427A, 428T, 431Y, 435Y, 436M, 439S, 450V, 451H, 454C, 455S, 458G, 459R, 462S
CDD
cd06174 (MFS)

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features