KWMTBOMO10946

Protein

Length

522 amino acids

Protein family membership

Methylmalonate-semialdehyde dehydrogenase (IPR010061)

Domains and repeats

Domain
20 - 502
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)
Domain
27 - 284
Aldehyde dehydrogenase N-terminal domain (IPR016162)
285 - 465
Aldehyde dehydrogenase, C-terminal (IPR016163)

1 50 100 150 200 250 300 350 400 450 522

Detailed signature matches

IPR010061

Methylmalonate-semialdehyde dehydrogenase
1. TIGR01722
  
  29 - 504
  
  TIGRFAMs
  TIGR01722 (TIGR01722)
2. cd07085 (ALDH_F6_MMSDH)
  
  28 - 504
  
  CDD
  cd07085 (ALDH_F6_MMSDH)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  20 - 502
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR016162

Aldehyde dehydrogenase N-terminal domain
1. G3DSA:3.40.60...
  
  27 - 284
  
  GENE3D
  G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  36 - 500
  
  Pfam
  PF00171 (Aldedh)
IPR016163

Aldehyde dehydrogenase, C-terminal
1. G3DSA:3.40.30...
  
  285 - 465
  
  GENE3D
  G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
IPR016160

Aldehyde dehydrogenase, cysteine active site
1. PS00070 (ALDEHYDE_D...)
  
  298 - 309
  
  PROSITE patterns
  PS00070 (ALDEHYDE_DEHYDR_CYS)

Residue annotation

tetrameric interfa...

85T

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

87L

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

91Q

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

94F

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

98R

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

131Q

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

134E

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

135H

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

144L

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

145G

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

146D

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

147S

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

148I

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

149Q

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

150N

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

151I

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

156D

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

159S

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

162V

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

255K

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

259T

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

262S

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

265G

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

267R

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

440T

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

442G

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

443A

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

445A

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

446R

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

449S

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

452I

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

453D

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

455G

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

457V

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

458G

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

459V

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

460N

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

469M

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

473S

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

475T

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

489Q

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

496E

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

497L

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

498K

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

499T

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

500V

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

501V

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

503F

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)

504W

tetrameric interface
85T, 87L, 91Q, 94F, 98R, 131Q, 134E, 135H, 144L, 145G, 146D, 147S, 148I, 149Q, 150N, 151I, 156D, 159S, 162V, 255K, 259T, 262S, 265G, 267R, 440T, 442G, 443A, 445A, 446R, 449S, 452I, 453D, 455G, 457V, 458G, 459V, 460N, 469M, 473S, 475T, 489Q, 496E, 497L, 498K, 499T, 500V, 501V, 503F, 504W
CDD
cd07085 (ALDH_F6_MMSDH)
NAD binding site c...

171A

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

172A

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

173F

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

174N

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

182W

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

197K

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

200E

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

230H

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

247F

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

248V

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

249G

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

250G

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

253A

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

271N

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

272M

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

273G

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

305C

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

405E

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

407F

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)

433N

NAD binding site
171A, 172A, 173F, 174N, 182W, 197K, 200E, 230H, 247F, 248V, 249G, 250G, 253A, 271N, 272M, 273G, 305C, 405E, 407F, 433N
CDD
cd07085 (ALDH_F6_MMSDH)
catalytic residues...

174N

catalytic residues
174N, 271N, 302G, 305C
CDD
cd07085 (ALDH_F6_MMSDH)

271N

catalytic residues
174N, 271N, 302G, 305C
CDD
cd07085 (ALDH_F6_MMSDH)

302G

catalytic residues
174N, 271N, 302G, 305C
CDD
cd07085 (ALDH_F6_MMSDH)

305C

catalytic residues
174N, 271N, 302G, 305C
CDD
cd07085 (ALDH_F6_MMSDH)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Cellular Component

None predicted.

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Entry type

Status

Per-residue features