KWMTBOMO10933

Protein

Length

1,336 amino acids

Protein family membership

Ribonuclease III (IPR011907)

Domains and repeats

Domain
742 - 952
Ribonuclease III domain (IPR000999)
978 - 1,128
Ribonuclease III domain (IPR000999)
1,129 - 1,205
Double-stranded RNA-binding domain (IPR014720)

1 200 400 600 800 1000 1200 1336

Detailed signature matches

IPR011907

Ribonuclease III
1. MF_00104 (RNase_III)
  
  982 - 1,200
  
  HAMAP
  MF_00104 (RNase_III)
IPR000999

Ribonuclease III domain
1. PF00636 (Ribonuclea...)
  
  1,016 - 1,102
  
  Pfam
  PF00636 (Ribonuclease_3)
2. cd00593 (RIBOc)
  
  994 - 1,124
  
  CDD
  cd00593 (RIBOc)
  
  830 - 945
  
  CDD
  cd00593 (RIBOc)
3. PS00517 (RNASE_3_1)
  
  837 - 845
  
  PROSITE patterns
  PS00517 (RNASE_3_1)
4. G3DSA:1.10.15...
  
  831 - 936
  
  GENE3D
  G3DSA:1.10.1520.10 (G3DSA:1.10.1520.10)
  
  749 - 784
  
  GENE3D
  G3DSA:1.10.1520.10 (G3DSA:1.10.1520.10)
  
  978 - 1,128
  
  GENE3D
  G3DSA:1.10.1520.10 (G3DSA:1.10.1520.10)
5. PS50142 (RNASE_3_2)
  
  979 - 1,103
  
  PROSITE profiles
  PS50142 (RNASE_3_2)
  
  749 - 927
  
  PROSITE profiles
  PS50142 (RNASE_3_2)
6. SM00535 (riboneu5)
  
  764 - 952
  
  SMART
  SM00535 (riboneu5)
  
  994 - 1,124
  
  SMART
  SM00535 (riboneu5)
7. SSF69065 (RNase III...)
  
  742 - 775
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  822 - 938
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  978 - 1,126
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
8. PF14622 (Ribonuclea...)
  
  830 - 937
  
  Pfam
  PF14622 (Ribonucleas_3_3)
IPR014720

Double-stranded RNA-binding domain
1. PS50137 (DS_RBD)
  
  1,130 - 1,205
  
  PROSITE profiles
  PS50137 (DS_RBD)
2. SM00358 (DRBM_3)
  
  1,131 - 1,204
  
  SMART
  SM00358 (DRBM_3)
3. G3DSA:3.30.16...
  
  1,129 - 1,201
  
  GENE3D
  G3DSA:3.30.160.20 (G3DSA:3.30.160.20)
4. PF00035 (dsrm)
  
  1,131 - 1,201
  
  Pfam
  PF00035 (dsrm)

no IPR

Unintegrated signatures

SSF54768 (dsRNA-bin...)

1,120 - 1,203

SUPERFAMILY
SSF54768 (dsRNA-binding domain-like)
mobidb-lite (disord...)

321 - 361

MobiDB Lite
mobidb-lite (disorder_prediction)

1,219 - 1,299

MobiDB Lite
mobidb-lite (disorder_prediction)

78 - 147

MobiDB Lite
mobidb-lite (disorder_prediction)

177 - 231

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd00593

837E

active site
837E, 840E, 844D, 913N, 916E
CDD
cd00593 (RIBOc)

840E

active site
837E, 840E, 844D, 913N, 916E
CDD
cd00593 (RIBOc)

844D

active site
837E, 840E, 844D, 913N, 916E
CDD
cd00593 (RIBOc)

913N

active site
837E, 840E, 844D, 913N, 916E
CDD
cd00593 (RIBOc)

916E

active site
837E, 840E, 844D, 913N, 916E
CDD
cd00593 (RIBOc)
dimerization inter...

837E

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

838R

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

841F

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

842L

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

845A

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

848E

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

849F

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

852S

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

853I

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

855L

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

856F

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

857K

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

867L

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

923F

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)

932D

dimerization interface
837E, 838R, 841F, 842L, 845A, 848E, 849F, 852S, 853I, 855L, 856F, 857K, 867L, 923F, 932D
CDD
cd00593 (RIBOc)
metal binding site...

840E

metal binding site
840E, 913N, 916E
CDD
cd00593 (RIBOc)

913N

metal binding site
840E, 913N, 916E
CDD
cd00593 (RIBOc)

916E

metal binding site
840E, 913N, 916E
CDD
cd00593 (RIBOc)
active site cd00593

1,016Q

active site
1,016Q, 1,019E, 1,023D, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

1,019E

active site
1,016Q, 1,019E, 1,023D, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

1,023D

active site
1,016Q, 1,019E, 1,023D, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

1,089D

active site
1,016Q, 1,019E, 1,023D, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

1,092E

active site
1,016Q, 1,019E, 1,023D, 1,089D, 1,092E
CDD
cd00593 (RIBOc)
dimerization inter...

1,016Q

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,017R

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,020F

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,021L

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,024T

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,027Q

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,028L

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,031S

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,032D

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,034L

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,035Y

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,036R

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,046L

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,099F

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)

1,108Q

dimerization interface
1,016Q, 1,017R, 1,020F, 1,021L, 1,024T, 1,027Q, 1,028L, 1,031S, 1,032D, 1,034L, 1,035Y, 1,036R, 1,046L, 1,099F, 1,108Q
CDD
cd00593 (RIBOc)
metal binding site...

1,019E

metal binding site
1,019E, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

1,089D

metal binding site
1,019E, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

1,092E

metal binding site
1,019E, 1,089D, 1,092E
CDD
cd00593 (RIBOc)

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0016075 rRNA catabolic process

Molecular Function

GO:0003723 RNA binding
GO:0004525 ribonuclease III activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features