KWMTBOMO10792

Protein

Length

361 amino acids

Protein family membership

GDP-mannose 4,6-dehydratase (IPR006368)

Domains and repeats

Domain
12 - 353
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 361

Detailed signature matches

IPR006368

GDP-mannose 4,6-dehydratase
1. TIGR01472
  
  13 - 355
  
  TIGRFAMs
  TIGR01472 (TIGR01472)
2. MF_00955 (GDP_Man_d...)
  
  13 - 357
  
  HAMAP
  MF_00955 (GDP_Man_dehydratase)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  16 - 347
  
  Pfam
  PF16363 (GDP_Man_Dehyd)
2. SSF51735 (NAD(P)-bi...)
  
  13 - 353
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
3. G3DSA:3.40.50...
  
  12 - 202
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

no IPR

Unintegrated signatures

G3DSA:3.90.25.10

204 - 258

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

305 - 358

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
cd05260 (GDP_MD_SDR_e)

15 - 353

CDD
cd05260 (GDP_MD_SDR_e)

Residue annotation

NADP-binding site ...

19G

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

20I

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

21T

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

22G

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

23Q

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

24D

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

44R

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

45R

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

46S

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

74G

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

75D

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

76L

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

97L

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

98G

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

99A

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

101S

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

116V

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

142A

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

143S

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

144T

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

168Y

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

172K

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

195L

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

196F

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

197N

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

198H

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)

199E

NADP-binding site
19G, 20I, 21T, 22G, 23Q, 24D, 44R, 45R, 46S, 74G, 75D, 76L, 97L, 98G, 99A, 101S, 116V, 142A, 143S, 144T, 168Y, 172K, 195L, 196F, 197N, 198H, 199E
CDD
cd05260 (GDP_MD_SDR_e)
homotetramer inter...

21T

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

22G

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

44R

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

45R

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

46S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

47S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

48S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

49F

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

52G

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

53R

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

73Y

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

74G

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

75D

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

77S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

78D

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

79T

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

80S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

81C

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

83I

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

84S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

85I

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

87A

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

99A

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

100Q

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

101S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

102H

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

105V

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

107F

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

108E

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

109L

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

110S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

114A

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

115Q

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

119L

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

122L

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

123R

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

126E

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

129R

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

130A

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

161P

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

162F

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

163Y

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

164P

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

166S

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

167P

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

170C

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

171A

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

173L

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

174Y

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

177W

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

178I

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

180V

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

181N

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

182Y

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

184E

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

185A

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

186Y

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

206N

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

207F

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

315P

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

316T

homotetramer interface
21T, 22G, 44R, 45R, 46S, 47S, 48S, 49F, 52G, 53R, 73Y, 74G, 75D, 77S, 78D, 79T, 80S, 81C, 83I, 84S, 85I, 87A, 99A, 100Q, 101S, 102H, 105V, 107F, 108E, 109L, 110S, 114A, 115Q, 119L, 122L, 123R, 126E, 129R, 130A, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 206N, 207F, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)
substrate binding ...

101S

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

102H

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

103V

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

144T

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

145S

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

146E

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

168Y

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

197N

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

206N

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

207F

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

208V

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

211K

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

228E

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

229L

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

230G

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

231N

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

234S

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

236R

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

270V

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

312Y

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

314R

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

317E

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)

318V

substrate binding site
101S, 102H, 103V, 144T, 145S, 146E, 168Y, 197N, 206N, 207F, 208V, 211K, 228E, 229L, 230G, 231N, 234S, 236R, 270V, 312Y, 314R, 317E, 318V
CDD
cd05260 (GDP_MD_SDR_e)
homodimer interfac...

107F

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

110S

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

114A

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

115Q

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

118A

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

119L

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

122L

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

123R

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

126E

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

161P

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

162F

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

163Y

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

164P

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

166S

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

167P

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

170C

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

171A

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

173L

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

174Y

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

177W

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

178I

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

180V

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

181N

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

182Y

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

184E

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

185A

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

186Y

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

315P

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)

316T

homodimer interface
107F, 110S, 114A, 115Q, 118A, 119L, 122L, 123R, 126E, 161P, 162F, 163Y, 164P, 166S, 167P, 170C, 171A, 173L, 174Y, 177W, 178I, 180V, 181N, 182Y, 184E, 185A, 186Y, 315P, 316T
CDD
cd05260 (GDP_MD_SDR_e)
active site cd05260

117D

active site
117D, 144T, 168Y, 172K
CDD
cd05260 (GDP_MD_SDR_e)

144T

active site
117D, 144T, 168Y, 172K
CDD
cd05260 (GDP_MD_SDR_e)

168Y

active site
117D, 144T, 168Y, 172K
CDD
cd05260 (GDP_MD_SDR_e)

172K

active site
117D, 144T, 168Y, 172K
CDD
cd05260 (GDP_MD_SDR_e)

GO term prediction

Biological Process

GO:0019673 GDP-mannose metabolic process

Molecular Function

GO:0008446 GDP-mannose 4,6-dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

KWMTBOMO10792

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component