KWMTBOMO10718

Protein

Length

2,312 amino acids

Protein family membership

Peptidase S1A, chymotrypsin family (IPR001314)

Domains and repeats

Domain
7 - 293
Peptidase S1, PA clan (IPR009003)
Serine proteases, trypsin domain (IPR001254)
330 - 576
Peptidase S1, PA clan (IPR009003)
Serine proteases, trypsin domain (IPR001254)
639 - 823
Endonuclease/exonuclease/phosphatase (IPR005135)
1,109 - 1,175
Reverse transcriptase domain (IPR000477)
1,451 - 1,672
Reverse transcriptase domain (IPR000477)
2,000 - 2,161
Ribonuclease H-like domain (IPR012337)
Integrase, catalytic core (IPR001584)

1 500 1000 1500 2000 2312

Detailed signature matches

IPR001314

Peptidase S1A, chymotrypsin family
1. PR00722 (CHYMOTRYPSIN)
  
  524 - 536
  
  PRINTS
  PR00722 (CHYMOTRYPSIN)
  
  365 - 380
  
  PRINTS
  PR00722 (CHYMOTRYPSIN)
  
  425 - 439
  
  PRINTS
  PR00722 (CHYMOTRYPSIN)
IPR009003

Peptidase S1, PA clan
1. SSF50494 (Trypsin-l...)
  
  7 - 268
  
  SUPERFAMILY
  SSF50494 (Trypsin-like serine proteases)
  
  330 - 571
  
  SUPERFAMILY
  SSF50494 (Trypsin-like serine proteases)
IPR001254

Serine proteases, trypsin domain
1. SM00020 (trypsin_2)
  
  38 - 268
  
  SMART
  SM00020 (trypsin_2)
  
  336 - 571
  
  SMART
  SM00020 (trypsin_2)
2. PS50240 (TRYPSIN_DOM)
  
  337 - 576
  
  PROSITE profiles
  PS50240 (TRYPSIN_DOM)
  
  39 - 293
  
  PROSITE profiles
  PS50240 (TRYPSIN_DOM)
3. PF00089 (Trypsin)
  
  337 - 570
  
  Pfam
  PF00089 (Trypsin)
  
  39 - 268
  
  Pfam
  PF00089 (Trypsin)
4. cd00190 (Tryp_SPc)
  
  39 - 264
  
  CDD
  cd00190 (Tryp_SPc)
  
  337 - 570
  
  CDD
  cd00190 (Tryp_SPc)
IPR005135

Endonuclease/exonuclease/phosphatase
1. G3DSA:3.60.10.10
  
  640 - 823
  
  GENE3D
  G3DSA:3.60.10.10 (G3DSA:3.60.10.10)
2. PF14529 (Exo_endo_p...)
  
  706 - 818
  
  Pfam
  PF14529 (Exo_endo_phos_2)
3. SSF56219 (DNase I-like)
  
  639 - 823
  
  SUPERFAMILY
  SSF56219 (DNase I-like)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,540 - 1,637
  
  Pfam
  PF00078 (RVT_1)
  
  1,109 - 1,175
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  1,451 - 1,672
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR012337

Ribonuclease H-like domain
1. G3DSA:3.30.42...
  
  2,006 - 2,159
  
  GENE3D
  G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
2. SSF53098 (Ribonucle...)
  
  2,000 - 2,155
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR001584

Integrase, catalytic core
1. PS50994 (INTEGRASE)
  
  2,002 - 2,161
  
  PROSITE profiles
  PS50994 (INTEGRASE)
2. PF00665 (rve)
  
  2,006 - 2,116
  
  Pfam
  PF00665 (rve)
IPR018114

Serine proteases, trypsin family, histidine active site
1. PS00134 (TRYPSIN_HIS)
  
  375 - 380
  
  PROSITE patterns
  PS00134 (TRYPSIN_HIS)
  
  78 - 83
  
  PROSITE patterns
  PS00134 (TRYPSIN_HIS)
IPR033116

Serine proteases, trypsin family, serine active site
1. PS00135 (TRYPSIN_SER)
  
  525 - 536
  
  PROSITE patterns
  PS00135 (TRYPSIN_SER)
  
  228 - 239
  
  PROSITE patterns
  PS00135 (TRYPSIN_SER)

no IPR

Unintegrated signatures

G3DSA:2.40.10.10

337 - 371

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

39 - 74

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

372 - 438

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

75 - 139

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

439 - 572

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)

140 - 268

GENE3D
G3DSA:2.40.10.10 (G3DSA:2.40.10.10)
G3DSA:3.10.10.10

1,539 - 1,574

GENE3D
G3DSA:3.10.10.10 (G3DSA:3.10.10.10)
G3DSA:3.30.70...

1,575 - 1,630

GENE3D
G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
SSF56672 (DNA/RNA p...)

1,493 - 1,836

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd01647 (RT_LTR)

1,540 - 1,637

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,731 - 1,850

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

2,292 - 2,312

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

cleavage site cd00...

39I

cleavage site
39I
CDD
cd00190 (Tryp_SPc)
active site cd00190

82H

active site
82H, 132D, 234S
CDD
cd00190 (Tryp_SPc)

132D

active site
82H, 132D, 234S
CDD
cd00190 (Tryp_SPc)

234S

active site
82H, 132D, 234S
CDD
cd00190 (Tryp_SPc)
substrate binding ...

228G

substrate binding sites
228G, 251S, 253G
CDD
cd00190 (Tryp_SPc)

251S

substrate binding sites
228G, 251S, 253G
CDD
cd00190 (Tryp_SPc)

253G

substrate binding sites
228G, 251S, 253G
CDD
cd00190 (Tryp_SPc)
cleavage site cd00...

337I

cleavage site
337I
CDD
cd00190 (Tryp_SPc)
active site cd00190

379H

active site
379H, 429D, 531S
CDD
cd00190 (Tryp_SPc)

429D

active site
379H, 429D, 531S
CDD
cd00190 (Tryp_SPc)

531S

active site
379H, 429D, 531S
CDD
cd00190 (Tryp_SPc)
substrate binding ...

525G

substrate binding sites
525G, 548S, 550G
CDD
cd00190 (Tryp_SPc)

548S

substrate binding sites
525G, 548S, 550G
CDD
cd00190 (Tryp_SPc)

550G

substrate binding sites
525G, 548S, 550G
CDD
cd00190 (Tryp_SPc)
putative NTP bindi...

1,541D

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,542L

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,543A

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,544S

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,545G

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,546Y

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,575F

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)

1,605D

putative NTP binding site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,605D
CDD
cd01647 (RT_LTR)
putative active si...

1,541D

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,542L

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,543A

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,544S

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,545G

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,546Y

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,575F

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,576G

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,603Y

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,605D

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,606D

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,633L

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)

1,634G

putative active site
1,541D, 1,542L, 1,543A, 1,544S, 1,545G, 1,546Y, 1,575F, 1,576G, 1,603Y, 1,605D, 1,606D, 1,633L, 1,634G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,576G

putative nucleic acid binding site
1,576G
CDD
cd01647 (RT_LTR)
active site cd09274

1,735D

active site
1,735D, 1,777E, 1,802D, 1,845D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,777E

active site
1,735D, 1,777E, 1,802D, 1,845D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,802D

active site
1,735D, 1,777E, 1,802D, 1,845D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,845D

active site
1,735D, 1,777E, 1,802D, 1,845D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,735D

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,736A

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,737C

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,738K

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,772H

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,773S

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,774Y

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,777E

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,802D

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,835Y

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,849R

RNA/DNA hybrid binding site
1,735D, 1,736A, 1,737C, 1,738K, 1,772H, 1,773S, 1,774Y, 1,777E, 1,802D, 1,835Y, 1,849R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0006508 proteolysis
GO:0015074 DNA integration

Molecular Function

GO:0003676 nucleic acid binding
GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features