KWMTBOMO10423

Protein

Length

421 amino acids

Protein family membership

Major facilitator superfamily (IPR011701)
- Tetracycline resistance protein TetA/multidrug resistance protein MdtG (IPR001958)

Domains and repeats

Domain
1 - 421
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 421

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  2 - 386
  
  Pfam
  PF07690 (MFS_1)
IPR001958

Tetracycline resistance protein TetA/multidrug resistance protein MdtG
1. PR01035 (TCRTETA)
  
  50 - 69
  
  PRINTS
  PR01035 (TCRTETA)
  
  138 - 160
  
  PRINTS
  PR01035 (TCRTETA)
  
  108 - 129
  
  PRINTS
  PR01035 (TCRTETA)
  
  81 - 105
  
  PRINTS
  PR01035 (TCRTETA)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  1 - 421
  
  PROSITE profiles
  PS50850 (MFS)
2. cd06174 (MFS)
  
  42 - 420
  
  CDD
  cd06174 (MFS)
3. SSF103473 (MFS gene...)
  
  45 - 420
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)

no IPR

Unintegrated signatures

G3DSA:1.20.12...

3 - 202

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

240 - 420

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

Residue annotation

putative substrate...

54G

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

57Y

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

58S

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

61Q

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

65S

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

66P

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

68V

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

69G

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

115K

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

116A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

119S

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

122M

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

123A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

126T

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

138M

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

139A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

142G

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

143L

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

149F

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

249L

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

252Y

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

253S

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

256E

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

257F

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

260T

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

274Q

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

278F

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

282G

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

285M

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

289Q

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

344A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

347T

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

348A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

351V

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

355T

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

356S

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

359A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

370V

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

371L

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

374L

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

375R

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

378G

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

379A

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

382R

putative substrate translocation pore
54G, 57Y, 58S, 61Q, 65S, 66P, 68V, 69G, 115K, 116A, 119S, 122M, 123A, 126T, 138M, 139A, 142G, 143L, 149F, 249L, 252Y, 253S, 256E, 257F, 260T, 274Q, 278F, 282G, 285M, 289Q, 344A, 347T, 348A, 351V, 355T, 356S, 359A, 370V, 371L, 374L, 375R, 378G, 379A, 382R
CDD
cd06174 (MFS)

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features

KWMTBOMO10423

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component