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Entry type
Status
Per-residue features
Colour by
Protein
KWMTBOMO10421
Length
985 amino acids
Protein family membership
- DNA topoisomerase, type IA (IPR000380)
Domains and repeats
-
Domain2 - 584
- DNA topoisomerase, type IA, core domain (IPR023405)
-
Domain2 - 166
- Toprim domain (IPR006171)
170 - 226291 - 413481 - 587625 - 663- DNA topoisomerase, type IA, zn finger (IPR013498)
803 - 846- Zinc finger, GRF-type (IPR010666)
892 - 934- Zinc finger, GRF-type (IPR010666)
-
Domain139 - 236
- DNA topoisomerase, type IA, domain 2 (IPR003601)
282 - 536- DNA topoisomerase, type IA, DNA-binding domain (IPR003602)
-
Domain163 - 584
- DNA topoisomerase, type IA, central (IPR013497)
1
100
200
300
400
500
600
700
800
900
985
Detailed signature matches
no IPR
Unintegrated signatures
-
617 - 658
-
cd03362 (TOPRIM_Top...)2 - 160
-
mobidb-lite (disord...)366 - 391934 - 956852 - 889
Residue annotation
-
active site cd033628E9K12A115D117D119E
-
putative interdoma...15Nputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)116Cputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)118Rputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)125Fputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)126Eputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)128Iputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)129Dputative interdomain interaction site
15N, 116C, 118R, 125F, 126E, 128I, 129D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII) -
putative metal-bin...
-
putative nucleotid...118R
-
domain I cd00186166Ndomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)167Tdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)168Sdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)169Ndomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)170Adomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)171Vdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)172Ddomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)173Vdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)174Rdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)175Qdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)176Edomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)177Ldomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)178Ddomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)179Ldomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)180Rdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)181Idomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)182Gdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)183Adomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)184Adomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)185Fdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)186Tdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)187Rdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)188Fdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)189Qdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)190Tdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)191Ldomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)192Rdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)206Vdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)207Sdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)208Ydomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)209Gdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)210Sdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)211Cdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)212Qdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)213Fdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)214Pdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)215Tdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)216Ldomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)217Gdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)218Fdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)219Vdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)220Vdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)221Edomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)222Rdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)223Ydomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)224Rdomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)225Adomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac)226Idomain I
166N, 167T, 168S, 169N, 170A, 171V, 172D, 173V, 174R, 175Q, 176E, 177L, 178D, 179L, 180R, 181I, 182G, 183A, 184A, 185F, 186T, 187R, 188F, 189Q, 190T, 191L, 192R, 206V, 207S, 208Y, 209G, 210S, 211C, 212Q, 213F, 214P, 215T, 216L, 217G, 218F, 219V, 220V, 221E, 222R, 223Y, 224R, 225A, 226I
CDD
cd00186 (TOP1Ac) -
DNA binding groove...174RDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)175QDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)178DDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)182GDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)186TDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)319EDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)323TDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)331RDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)503ADNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)504TDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)507EDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)508HDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)510EDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)514SDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac)515RDNA binding groove
174R, 175Q, 178D, 182G, 186T, 319E, 323T, 331R, 503A, 504T, 507E, 508H, 510E, 514S, 515R
CDD
cd00186 (TOP1Ac) -
phosphate binding ...
-
domain II cd00186231Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)232Edomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)233Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)234Fdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)235Wdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)236Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)237Ldomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)238Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)239Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)276Adomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)277Rdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)278Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)279Ldomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)280Edomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)281Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)282Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)283Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)284Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)285Pdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)286Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)287Sdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)288Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)289Wdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)414Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)415Ddomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)416Adomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)417Qdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)418Gdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)419Qdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)420Edomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)421Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)422Idomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)423Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)424Ndomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)425Idomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)426Ddomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)427Idomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)428Gdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)430Edomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)431Kdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)432Fdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)433Sdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)434Adomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)435Ndomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)436Gdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)437Ldomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)438Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)439Idomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)440Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)441Edomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)442Ldomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)443Ndomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)444Ydomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)445Ldomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)446Edomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)447Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)448Ydomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)470Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)471Sdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)472Idomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)473Ddomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)474Idomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)475Vdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)476Sdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)477Gdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)478Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)479Tdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac)480Sdomain II
231V, 232E, 233T, 234F, 235W, 236K, 237L, 238K, 239V, 276A, 277R, 278V, 279L, 280E, 281V, 282K, 283T, 284K, 285P, 286K, 287S, 288K, 289W, 414K, 415D, 416A, 417Q, 418G, 419Q, 420E, 421T, 422I, 423V, 424N, 425I, 426D, 427I, 428G, 430E, 431K, 432F, 433S, 434A, 435N, 436G, 437L, 438V, 439I, 440T, 441E, 442L, 443N, 444Y, 445L, 446E, 447V, 448Y, 470T, 471S, 472I, 473D, 474I, 475V, 476S, 477G, 478T, 479T, 480S
CDD
cd00186 (TOP1Ac) -
domain III cd00186290Rdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)291Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)292Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)293Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)294Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)295Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)296Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)298Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)299Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)300Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)301Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)302Qdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)303Adomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)304Sdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)305Rdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)306Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)307Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)308Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)309Idomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)310Hdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)311Adomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)312Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)313Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)314Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)315Mdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)316Qdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)317Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)318Adomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)319Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)320Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)321Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)322Ydomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)323Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)324Qdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)325Gdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)326Fdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)327Idomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)328Sdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)329Ydomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)330Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)331Rdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)332Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)333Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)334Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)335Ndomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)336Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)337Fdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)338Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)339Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)340Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)341Mdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)342Ndomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)343Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)344Adomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)345Qdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)346Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)347Vdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)348Gdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)349Qdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)350Qdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)351Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)352Gdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)353Ddomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)380Adomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)381Hdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)382Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)383Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)384Idomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)385Hdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)386Pdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)387Tdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)388Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)393Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)394Sdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)395Gdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)396Ndomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)397Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)398Kdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)399Rdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)400Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)401Ydomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)402Edomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)403Fdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)404Idomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)405Vdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)406Rdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)407Sdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)408Fdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)409Ldomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)410Adomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)411Cdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)412Cdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac)413Sdomain III
290R, 291P, 292L, 293P, 294L, 295E, 296T, 298E, 299L, 300E, 301K, 302Q, 303A, 304S, 305R, 306K, 307L, 308K, 309I, 310H, 311A, 312K, 313E, 314T, 315M, 316Q, 317L, 318A, 319E, 320K, 321L, 322Y, 323T, 324Q, 325G, 326F, 327I, 328S, 329Y, 330P, 331R, 332T, 333E, 334T, 335N, 336E, 337F, 338P, 339K, 340E, 341M, 342N, 343L, 344A, 345Q, 346L, 347V, 348G, 349Q, 350Q, 351T, 352G, 353D, 380A, 381H, 382P, 383P, 384I, 385H, 386P, 387T, 388K, 393L, 394S, 395G, 396N, 397E, 398K, 399R, 400L, 401Y, 402E, 403F, 404I, 405V, 406R, 407S, 408F, 409L, 410A, 411C, 412C, 413S
CDD
cd00186 (TOP1Ac) -
nucleotide binding...301Knucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)305Rnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)306Knucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)307Lnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)381Hnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)399Rnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)402Enucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)406Rnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)501Tnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)503Anucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac)526Fnucleotide binding site
301K, 305R, 306K, 307L, 381H, 399R, 402E, 406R, 501T, 503A, 526F
CDD
cd00186 (TOP1Ac) -
catalytic site cd0...
-
domain IV cd00186481Pdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)482Pdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)483Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)484Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)485Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)486Tdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)487Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)488Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)489Ddomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)490Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)491Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)492Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)493Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)494Mdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)495Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)496Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)497Hdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)498Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)499Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)500Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)501Tdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)502Ddomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)503Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)504Tdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)505Hdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)506Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)507Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)508Hdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)509Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)510Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)511Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)512Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)513Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)514Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)515Rdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)516Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)517Ydomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)518Vdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)519Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)520Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)522Ddomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)526Fdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)527Vdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)528Pdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)529Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)530Vdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)531Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)532Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)533Mdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)534Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)535Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)536Vdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)537Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)538Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)539Ydomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)540Ddomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)546Mdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)547Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)548Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)549Pdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)550Hdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)551Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)552Rdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)553Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)554Qdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)555Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)556Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)557Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)558Ddomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)559Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)560Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)561Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)562Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)563Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)564Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)565Gdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)566Rdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)567Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)568Qdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)569Pdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)570Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)571Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)572Vdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)573Ldomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)574Sdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)575Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)576Qdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)577Idomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)578Adomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)579Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)580Ydomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)581Kdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)582Edomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)583Vdomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)584Ydomain IV
481P, 482P, 483S, 484L, 485L, 486T, 487E, 488A, 489D, 490L, 491I, 492S, 493L, 494M, 495E, 496K, 497H, 498G, 499I, 500G, 501T, 502D, 503A, 504T, 505H, 506A, 507E, 508H, 509I, 510E, 511K, 512I, 513K, 514S, 515R, 516S, 517Y, 518V, 519A, 520L, 522D, 526F, 527V, 528P, 529G, 530V, 531L, 532G, 533M, 534G, 535L, 536V, 537E, 538G, 539Y, 540D, 546M, 547S, 548K, 549P, 550H, 551L, 552R, 553A, 554Q, 555L, 556E, 557S, 558D, 559L, 560K, 561E, 562I, 563I, 564E, 565G, 566R, 567K, 568Q, 569P, 570E, 571A, 572V, 573L, 574S, 575E, 576Q, 577I, 578A, 579K, 580Y, 581K, 582E, 583V, 584Y
CDD
cd00186 (TOP1Ac)
GO term prediction
Biological Process
GO:0006265 DNA topological change
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity
GO:0008270 zinc ion binding
Cellular Component
GO:0005694 chromosome