KWMTBOMO10407

Protein

Length

323 amino acids

Protein family membership

Peptidase T2, asparaginase 2 (IPR000246)
- Asparaginase-like 1, metazoa (IPR033844)

Domains and repeats

Domain
14 - 313
Nucleophile aminohydrolases, N-terminal (IPR029055)

1 50 100 150 200 250 323

Detailed signature matches

IPR000246

Peptidase T2, asparaginase 2
1. PF01112 (Asparagina...)
  
  16 - 309
  
  Pfam
  PF01112 (Asparaginase_2)
IPR033844

Asparaginase-like 1, metazoa
1. cd04702 (ASRGL1_like)
  
  15 - 307
  
  CDD
  cd04702 (ASRGL1_like)
IPR029055

Nucleophile aminohydrolases, N-terminal
1. SSF56235 (N-termina...)
  
  14 - 313
  
  SUPERFAMILY
  SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))

Residue annotation

dimer interface cd...

94M

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

96G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

98D

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

99L

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

124T

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

126H

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

127S

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

128F

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

129L

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

130G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

131G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

132N

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

133G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

136L

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

137F

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

208K

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

209M

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

210V

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

211G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

212R

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

213I

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

219I

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

220G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

224Y

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

226D

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

239E

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

243K

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

244Y

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

245C

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

248H

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

252K

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

256G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

270G

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

274R

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)

275L

dimer interface
94M, 96G, 98D, 99L, 124T, 126H, 127S, 128F, 129L, 130G, 131G, 132N, 133G, 136L, 137F, 208K, 209M, 210V, 211G, 212R, 213I, 219I, 220G, 224Y, 226D, 239E, 243K, 244Y, 245C, 248H, 252K, 256G, 270G, 274R, 275L
CDD
cd04702 (ASRGL1_like)
catalytic nucleoph...

184T

catalytic nucleophile
184T
CDD
cd04702 (ASRGL1_like)
active site cd04702

184T

active site
184T, 200T, 212R, 215D, 235T
CDD
cd04702 (ASRGL1_like)

200T

active site
184T, 200T, 212R, 215D, 235T
CDD
cd04702 (ASRGL1_like)

212R

active site
184T, 200T, 212R, 215D, 235T
CDD
cd04702 (ASRGL1_like)

215D

active site
184T, 200T, 212R, 215D, 235T
CDD
cd04702 (ASRGL1_like)

235T

active site
184T, 200T, 212R, 215D, 235T
CDD
cd04702 (ASRGL1_like)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004067 asparaginase activity
GO:0016787 hydrolase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO10407

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component