KWMTBOMO10392

Protein

Length

2,064 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
324 - 540
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
581 - 801
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,066 - 1,176
Tetratricopeptide-like helical domain (IPR011990)
1,235 - 1,236
Tetratricopeptide-like helical domain (IPR011990)
1,361 - 1,486
Tetratricopeptide-like helical domain (IPR011990)
1,512 - 1,601
Armadillo-type fold (IPR016024)
2,032 - 2,064
FATC domain (IPR003152)
Domain
552 - 658
UME domain (IPR012993)
1,065 - 1,613
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
1,714 - 2,064
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 200 400 600 800 1000 1200 1400 1600 1800 2064

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  324 - 532
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  697 - 793
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,512 - 1,601
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  480 - 540
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  581 - 801
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR012993

UME domain
1. PF08064 (UME)
  
  555 - 655
  
  Pfam
  PF08064 (UME)
2. SM00802 (UME_cls)
  
  552 - 658
  
  SMART
  SM00802 (UME_cls)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,065 - 1,613
  
  PROSITE profiles
  PS51189 (FAT)
IPR011990

Tetratricopeptide-like helical domain
1. G3DSA:1.25.40.10
  
  1,361 - 1,486
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  1,235 - 1,236
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
  
  1,066 - 1,176
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,190 - 1,528
  
  Pfam
  PF02259 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,858 - 2,021
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,714 - 1,826
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. G3DSA:1.10.10...
  
  1,798 - 1,813
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
  
  1,865 - 2,056
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
2. SM00146 (pi3k_hr1_6)
  
  1,750 - 2,053
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  1,751 - 1,992
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. PS50290 (PI3_4_KINA...)
  
  1,749 - 2,064
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,032 - 2,064
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,034 - 2,064
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,032 - 2,064
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  1,887 - 1,907
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

1,705 - 1,797

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
cd00892 (PIKKc_ATR)

1,720 - 1,994

CDD
cd00892 (PIKKc_ATR)

Residue annotation

ATP binding site c...

1,730L

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,732S

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,733L

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,734Q

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,736P

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,752M

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,754K

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,757D

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,792Y

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,804I

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,805E

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,806W

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,807V

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,812G

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,907N

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,909S

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,920V

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)

1,921D

ATP binding site
1,730L, 1,732S, 1,733L, 1,734Q, 1,736P, 1,752M, 1,754K, 1,757D, 1,792Y, 1,804I, 1,805E, 1,806W, 1,807V, 1,812G, 1,907N, 1,909S, 1,920V, 1,921D
CDD
cd00892 (PIKKc_ATR)
catalytic loop cd0...

1,899G

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,900L

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,901G

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,902D

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,903R

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,904H

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,905G

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,906E

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)

1,907N

catalytic loop
1,899G, 1,900L, 1,901G, 1,902D, 1,903R, 1,904H, 1,905G, 1,906E, 1,907N
CDD
cd00892 (PIKKc_ATR)
activation loop (A...

1,921D

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,922F

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,923N

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,924C

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,925L

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,926F

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,927N

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,928R

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,929G

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,930E

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,931R

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,932F

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,933E

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,934W

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,935P

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,936E

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,937R

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,938V

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,939P

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,940F

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,941R

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,942L

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

1,943T

activation loop (A-loop)
1,921D, 1,922F, 1,923N, 1,924C, 1,925L, 1,926F, 1,927N, 1,928R, 1,929G, 1,930E, 1,931R, 1,932F, 1,933E, 1,934W, 1,935P, 1,936E, 1,937R, 1,938V, 1,939P, 1,940F, 1,941R, 1,942L, 1,943T
CDD
cd00892 (PIKKc_ATR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

KWMTBOMO10392

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component