KWMTBOMO10231

Protein

Length

892 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
33 - 253
Quinoprotein alcohol dehydrogenase-like superfamily (IPR011047)
Quinoprotein alcohol dehydrogenase-like domain (IPR027295)
790 - 892
KEN domain (IPR010513)
Domain
527 - 792
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
Repeat
33 - 63
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)
117 - 149
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)
165 - 196
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)
209 - 241
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)
290 - 321
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)

1 100 200 300 400 500 600 700 800 892

Detailed signature matches

IPR011047

Quinoprotein alcohol dehydrogenase-like superfamily
1. SSF50998 (Quinoprot...)
  
  33 - 248
  
  SUPERFAMILY
  SSF50998 (Quinoprotein alcohol dehydrogenase-like)
IPR027295

Quinoprotein alcohol dehydrogenase-like domain
1. G3DSA:2.140.1...
  
  198 - 253
  
  GENE3D
  G3DSA:2.140.10.10 (G3DSA:2.140.10.10)
  
  33 - 146
  
  GENE3D
  G3DSA:2.140.10.10 (G3DSA:2.140.10.10)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  527 - 792
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. SM00220 (serkin_6)
  
  527 - 787
  
  SMART
  SM00220 (serkin_6)
2. PS50011 (PROTEIN_KI...)
  
  527 - 787
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
3. PF00069 (Pkinase)
  
  527 - 787
  
  Pfam
  PF00069 (Pkinase)
IPR010513

KEN domain
1. PF06479 (Ribonuc_2-5A)
  
  794 - 862
  
  Pfam
  PF06479 (Ribonuc_2-5A)
2. PS51392 (KEN)
  
  790 - 892
  
  PROSITE profiles
  PS51392 (KEN)
IPR018391

Pyrrolo-quinoline quinone beta-propeller repeat
1. SM00564 (ire1_9)
  
  165 - 196
  
  SMART
  SM00564 (ire1_9)
  
  209 - 241
  
  SMART
  SM00564 (ire1_9)
  
  33 - 63
  
  SMART
  SM00564 (ire1_9)
  
  117 - 149
  
  SMART
  SM00564 (ire1_9)
  
  290 - 321
  
  SMART
  SM00564 (ire1_9)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  640 - 652
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

633 - 790

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

496 - 632

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd09769 (Luminal_IRE1)

39 - 311

CDD
cd09769 (Luminal_IRE1)
cd13982 (STKc_IRE1)

524 - 788

CDD
cd13982 (STKc_IRE1)

Residue annotation

homodimer interfac...

115N

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

116A

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

117P

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

118C

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

119R

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

125L

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

127T

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

128G

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

129K

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

130K

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

132D

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

133T

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

134W

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

146H

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

148S

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

149G

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

150F

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

153S

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

175A

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

176R

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

184H

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

186S

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

201T

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

203L

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

204A

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)

205M

homodimer interface
115N, 116A, 117P, 118C, 119R, 125L, 127T, 128G, 129K, 130K, 132D, 133T, 134W, 146H, 148S, 149G, 150F, 153S, 175A, 176R, 184H, 186S, 201T, 203L, 204A, 205M
CDD
cd09769 (Luminal_IRE1)
dimer interface (b...

524K

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

547F

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

548D

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

550R

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

573R

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

574E

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

576D

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

578H

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

583R

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

584Y

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

585Y

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

586C

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

587T

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

599E

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

630M

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

633S

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

634H

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

637S

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

638M

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

662R

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

779E

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)

782L

dimer interface (back-to-back)
524K, 547F, 548D, 550R, 573R, 574E, 576D, 578H, 583R, 584Y, 585Y, 586C, 587T, 599E, 630M, 633S, 634H, 637S, 638M, 662R, 779E, 782L
CDD
cd13982 (STKc_IRE1)
oligomer interface...

530D

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

544R

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

679V

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

680S

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

706T

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

750K

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

751I

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

752L

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)

777P

oligomer interface
530D, 544R, 679V, 680S, 706T, 750K, 751I, 752L, 777P
CDD
cd13982 (STKc_IRE1)
ATP binding site c...

533L

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

534G

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

535K

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

536G

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

537C

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

540T

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

542V

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

553A

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

555K

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

582V

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

598L

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

599E

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

601C

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

604T

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

648H

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

649N

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

651L

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)

667D

ATP binding site
533L, 534G, 535K, 536G, 537C, 540T, 542V, 553A, 555K, 582V, 598L, 599E, 601C, 604T, 648H, 649N, 651L, 667D
CDD
cd13982 (STKc_IRE1)
active site cd13982

533L

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

534G

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

535K

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

536G

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

537C

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

542V

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

553A

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

555K

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

582V

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

598L

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

599E

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

600L

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

601C

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

604T

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

606Q

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

644D

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

646K

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

648H

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

649N

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

651L

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

667D

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

670L

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

689G

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

690T

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

691D

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

692G

active site
533L, 534G, 535K, 536G, 537C, 542V, 553A, 555K, 582V, 598L, 599E, 600L, 601C, 604T, 606Q, 644D, 646K, 648H, 649N, 651L, 667D, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)
dimer interface (f...

535K

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

538E

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

539G

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

541F

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

556R

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

558L

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

590D

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

592Q

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

593F

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

732L

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

733R

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

735Q

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

736A

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)

739L

dimer interface (face-to-face)
535K, 538E, 539G, 541F, 556R, 558L, 590D, 592Q, 593F, 732L, 733R, 735Q, 736A, 739L
CDD
cd13982 (STKc_IRE1)
polypeptide substr...

537C

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

604T

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

606Q

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

644D

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

646K

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

648H

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

670L

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

689G

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

690T

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

691D

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

692G

polypeptide substrate binding site
537C, 604T, 606Q, 644D, 646K, 648H, 670L, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)
activation loop (A...

666S

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

667D

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

668F

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

669G

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

670L

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

671S

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

672K

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

673K

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

674L

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

675N

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

676I

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

677G

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

678R

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

679V

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

680S

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

681F

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

685S

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

686G

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

687V

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

688T

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

689G

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

690T

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

691D

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

692G

activation loop (A-loop)
666S, 667D, 668F, 669G, 670L, 671S, 672K, 673K, 674L, 675N, 676I, 677G, 678R, 679V, 680S, 681F, 685S, 686G, 687V, 688T, 689G, 690T, 691D, 692G
CDD
cd13982 (STKc_IRE1)

GO term prediction

Biological Process

GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

Molecular Function

GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component