KWMTBOMO10187

Protein

Length

372 amino acids

Protein family membership

Alcohol dehydrogenase, zinc-binding type 1 (IPR014182)

Domains and repeats

Domain
36 - 192
GroES-like (IPR011032)
Alcohol dehydrogenase, N-terminal (IPR013154)
Domain
49 - 369
Polyketide synthase, enoylreductase domain (IPR020843)
Domain
153 - 334
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 372

Detailed signature matches

IPR014182

Alcohol dehydrogenase, zinc-binding type 1
1. TIGR02817
  
  38 - 372
  
  TIGRFAMs
  TIGR02817 (TIGR02817)
2. cd08252 (AL_MDR)
  
  37 - 370
  
  CDD
  cd08252 (AL_MDR)
IPR011032

GroES-like
1. G3DSA:3.90.18...
  
  36 - 192
  
  GENE3D
  G3DSA:3.90.180.10 (G3DSA:3.90.180.10)
2. SSF50129 (GroES-like)
  
  43 - 175
  
  SUPERFAMILY
  SSF50129 (GroES-like)
IPR020843

Polyketide synthase, enoylreductase domain
1. SM00829 (PKS_ER_nam...)
  
  49 - 369
  
  SMART
  SM00829 (PKS_ER_names_mod)
IPR013154

Alcohol dehydrogenase, N-terminal
1. PF08240 (ADH_N)
  
  67 - 125
  
  Pfam
  PF08240 (ADH_N)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  153 - 320
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  193 - 334
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

no IPR

Unintegrated signatures

PF13602 (ADH_zinc_N_2)

228 - 369

Pfam
PF13602 (ADH_zinc_N_2)

Residue annotation

putative NAD(P) bi...

79N

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

80P

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

81I

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

84K

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

163L

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

167T

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

191N

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

192S

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

193A

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

194G

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

196V

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

197G

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

215A

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

216S

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

220T

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

235H

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

258N

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

259Y

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

261P

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

281I

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

282V

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

303E

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

304M

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)

305M

putative NAD(P) binding site
79N, 80P, 81I, 84K, 163L, 167T, 191N, 192S, 193A, 194G, 196V, 197G, 215A, 216S, 220T, 235H, 258N, 259Y, 261P, 281I, 282V, 303E, 304M, 305M
CDD
cd08252 (AL_MDR)
dimer interface cd...

170E

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

174D

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

175R

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

265W

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

274P

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

275Q

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

283D

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

287L

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

288V

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

289D

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

290L

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

291R

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

293L

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

294K

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

295D

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

296K

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

297S

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

298V

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

299T

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

300L

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

301V

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

302S

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

303E

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

304M

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

307T

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

308R

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

311Y

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

313T

dimer interface
170E, 174D, 175R, 265W, 274P, 275Q, 283D, 287L, 288V, 289D, 290L, 291R, 293L, 294K, 295D, 296K, 297S, 298V, 299T, 300L, 301V, 302S, 303E, 304M, 307T, 308R, 311Y, 313T
CDD
cd08252 (AL_MDR)

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features