KWMTBOMO09819

Protein

Length

519 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
21 - 277
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
332 - 518
KA1 domain/Ssp2, C-terminal (IPR028375)
AMPK, C-terminal adenylate sensor domain (IPR032270)

1 50 100 150 200 250 300 350 400 450 519

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  21 - 277
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. SM00220 (serkin_6)
  
  24 - 276
  
  SMART
  SM00220 (serkin_6)
2. PS50011 (PROTEIN_KI...)
  
  24 - 276
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
3. PF00069 (Pkinase)
  
  24 - 276
  
  Pfam
  PF00069 (Pkinase)
IPR028375

KA1 domain/Ssp2, C-terminal
1. SSF103243 (KA1-like)
  
  332 - 518
  
  SUPERFAMILY
  SSF103243 (KA1-like)
IPR032270

AMPK, C-terminal adenylate sensor domain
1. PF16579 (AdenylateS...)
  
  398 - 474
  
  Pfam
  PF16579 (AdenylateSensor)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  30 - 53
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  143 - 155
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

90 - 279

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

19 - 89

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd12122 (AMPKA_C)

396 - 517

CDD
cd12122 (AMPKA_C)
cd14079 (STKc_AMPK_...)

21 - 276

CDD
cd14079 (STKc_AMPK_alpha)
cd14336 (UBA_AID_AM...)

293 - 357

CDD
cd14336 (UBA_AID_AMPKalpha)
mobidb-lite (disord...)

470 - 501

MobiDB Lite
mobidb-lite (disorder_prediction)

359 - 396

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

30L

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

31G

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

32V

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

33G

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

38V

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

51A

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

53K

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

85I

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

101M

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

102E

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

103Y

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

104V

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

108E

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

151E

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

152N

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

154L

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

164A

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)

165D

ATP binding site
30L, 31G, 32V, 33G, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 151E, 152N, 154L, 164A, 165D
CDD
cd14079 (STKc_AMPK_alpha)
active site cd14079

30L

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

31G

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

32V

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

33G

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

34T

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

38V

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

51A

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

53K

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

85I

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

101M

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

102E

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

103Y

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

104V

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

108E

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

110F

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

111D

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

113I

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

146R

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

147D

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

149K

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

151E

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

152N

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

154L

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

164A

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

165D

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

168L

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

182C

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

183G

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

184S

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

185P

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

186N

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

188A

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

218G

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

219T

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

220L

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

221P

active site
30L, 31G, 32V, 33G, 34T, 38V, 51A, 53K, 85I, 101M, 102E, 103Y, 104V, 108E, 110F, 111D, 113I, 146R, 147D, 149K, 151E, 152N, 154L, 164A, 165D, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)
polypeptide substr...

108E

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

110F

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

111D

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

113I

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

147D

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

149K

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

151E

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

168L

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

182C

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

183G

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

184S

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

185P

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

186N

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

188A

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

218G

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

219T

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

220L

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)

221P

polypeptide substrate binding site
108E, 110F, 111D, 113I, 147D, 149K, 151E, 168L, 182C, 183G, 184S, 185P, 186N, 188A, 218G, 219T, 220L, 221P
CDD
cd14079 (STKc_AMPK_alpha)
activation loop (A...

164A

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

165D

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

166F

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

167G

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

168L

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

169S

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

170N

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

171M

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

172M

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

173M

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

174D

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

175G

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

176E

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

177F

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

178L

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

179R

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

180T

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

181S

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

182C

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

183G

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

184S

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

185P

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)

186N

activation loop (A-loop)
164A, 165D, 166F, 167G, 168L, 169S, 170N, 171M, 172M, 173M, 174D, 175G, 176E, 177F, 178L, 179R, 180T, 181S, 182C, 183G, 184S, 185P, 186N
CDD
cd14079 (STKc_AMPK_alpha)
heterotrimer inter...

172M

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

173M

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

174D

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

175G

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

176E

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

177F

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

196K

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

197L

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

199A

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

202E

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)

262M

heterotrimer interface
172M, 173M, 174D, 175G, 176E, 177F, 196K, 197L, 199A, 202E, 262M
CDD
cd14079 (STKc_AMPK_alpha)
beta subunit inter...

397A

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

398K

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

399W

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

400H

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

401L

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

402G

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

409P

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

410N

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

414L

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

417F

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

418R

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

421K

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

425Y

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

426E

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

427W

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

429V

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

430I

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

431N

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

432P

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

433Y

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

436R

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

437V

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

438R

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

449K

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

453Q

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

454L

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

455Y

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

456Q

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

457V

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

462Y

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

463L

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

465D

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

466F

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

467K

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

468S

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

501H

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

503T

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

504M

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

506F

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

507F

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

508E

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

510C

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

511A

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

514I

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)

515I

beta subunit interface
397A, 398K, 399W, 400H, 401L, 402G, 409P, 410N, 414L, 417F, 418R, 421K, 425Y, 426E, 427W, 429V, 430I, 431N, 432P, 433Y, 436R, 437V, 438R, 449K, 453Q, 454L, 455Y, 456Q, 457V, 462Y, 463L, 465D, 466F, 467K, 468S, 501H, 503T, 504M, 506F, 507F, 508E, 510C, 511A, 514I, 515I
CDD
cd12122 (AMPKA_C)
gamma subunit inte...

441N

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

443M

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

501H

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

502H

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

504M

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

505E

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

508E

gamma subunit interface
441N, 443M, 501H, 502H, 504M, 505E, 508E
CDD
cd12122 (AMPKA_C)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component