KWMTBOMO09518

Protein

Length

1,917 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
1 - 100
Beta-ketoacyl synthase, N-terminal (IPR014030)
105 - 221
Beta-ketoacyl synthase, C-terminal (IPR014031)
224 - 335
Ketoacyl-synthetase, C-terminal extension (IPR032821)
1,270 - 1,586
Polyketide synthase, enoylreductase domain (IPR020843)
Domain
1 - 270
Thiolase-like (IPR016039)
485 - 542
Malonyl-CoA ACP transacylase, ACP-binding (IPR016036)
1,364 - 1,546
NAD(P)-binding domain (IPR016040)
1,617 - 1,811
NAD(P)-binding domain (IPR016040)
Polyketide synthase, ketoreductase domain (IPR013968)
1,854 - 1,917
Phosphopantetheine binding ACP domain (IPR009081)
Polyketide synthase, phosphopantetheine-binding domain (IPR020806)
Domain
1 - 271
Polyketide synthase, beta-ketoacyl synthase domain (IPR020841)
357 - 677
Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035)
Acyl transferase domain (IPR001227)
Acyl transferase (IPR014043)
Polyketide synthase, acyl transferase domain (IPR020801)
723 - 969
Polyketide synthase, dehydratase domain (IPR020807)
1,276 - 1,406
GroES-like (IPR011032)
1,411 - 1,545
Alcohol dehydrogenase, C-terminal (IPR013149)

1 200 400 600 800 1000 1200 1400 1600 1800 1917

Detailed signature matches

IPR014030

Beta-ketoacyl synthase, N-terminal
1. PF00109 (ketoacyl-synt)
  
  1 - 100
  
  Pfam
  PF00109 (ketoacyl-synt)
IPR016039

Thiolase-like
1. G3DSA:3.40.47.10
  
  113 - 270
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
  
  1 - 106
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
2. SSF53901 (Thiolase-...)
  
  1 - 103
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  68 - 269
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
IPR020841

Polyketide synthase, beta-ketoacyl synthase domain
1. SM00825 (PKS_KS)
  
  1 - 271
  
  SMART
  SM00825 (PKS_KS)
IPR014031

Beta-ketoacyl synthase, C-terminal
1. PF02801 (Ketoacyl-s...)
  
  105 - 221
  
  Pfam
  PF02801 (Ketoacyl-synt_C)
IPR032821

Ketoacyl-synthetase, C-terminal extension
1. PF16197 (KAsynt_C_a...)
  
  224 - 335
  
  Pfam
  PF16197 (KAsynt_C_assoc)
IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase
1. SSF52151 (FabD/lyso...)
  
  360 - 485
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
  
  548 - 645
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
IPR001227

Acyl transferase domain
1. G3DSA:3.40.36...
  
  357 - 480
  
  GENE3D
  G3DSA:3.40.366.10 (G3DSA:3.40.366.10)
  
  547 - 671
  
  GENE3D
  G3DSA:3.40.366.10 (G3DSA:3.40.366.10)
IPR014043

Acyl transferase
1. PF00698 (Acyl_transf_1)
  
  361 - 677
  
  Pfam
  PF00698 (Acyl_transf_1)
IPR020801

Polyketide synthase, acyl transferase domain
1. SM00827 (PKS_AT)
  
  363 - 657
  
  SMART
  SM00827 (PKS_AT)
IPR016036

Malonyl-CoA ACP transacylase, ACP-binding
1. SSF55048 (Probable ...)
  
  485 - 542
  
  SUPERFAMILY
  SSF55048 (Probable ACP-binding domain of malonyl-CoA ACP transacylase)
IPR020807

Polyketide synthase, dehydratase domain
1. PF14765 (PS-DH)
  
  723 - 969
  
  Pfam
  PF14765 (PS-DH)
IPR020843

Polyketide synthase, enoylreductase domain
1. SM00829 (PKS_ER_nam...)
  
  1,270 - 1,586
  
  SMART
  SM00829 (PKS_ER_names_mod)
IPR011032

GroES-like
1. SSF50129 (GroES-like)
  
  1,276 - 1,406
  
  SUPERFAMILY
  SSF50129 (GroES-like)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  1,617 - 1,811
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  1,372 - 1,536
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  1,617 - 1,809
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  1,364 - 1,546
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR013149

Alcohol dehydrogenase, C-terminal
1. PF00107 (ADH_zinc_N)
  
  1,411 - 1,545
  
  Pfam
  PF00107 (ADH_zinc_N)
IPR013968

Polyketide synthase, ketoreductase domain
1. PF08659 (KR)
  
  1,619 - 1,797
  
  Pfam
  PF08659 (KR)
IPR009081

Phosphopantetheine binding ACP domain
1. G3DSA:1.10.12...
  
  1,856 - 1,916
  
  GENE3D
  G3DSA:1.10.1200.10 (G3DSA:1.10.1200.10)
2. PS50075 (ACP_DOMAIN)
  
  1,854 - 1,917
  
  PROSITE profiles
  PS50075 (ACP_DOMAIN)
3. PF00550 (PP-binding)
  
  1,858 - 1,910
  
  Pfam
  PF00550 (PP-binding)
4. SSF47336 (ACP-like)
  
  1,858 - 1,913
  
  SUPERFAMILY
  SSF47336 (ACP-like)
IPR020806

Polyketide synthase, phosphopantetheine-binding domain
1. SM00823 (PKS_PP)
  
  1,855 - 1,913
  
  SMART
  SM00823 (PKS_PP)
IPR018201

Beta-ketoacyl synthase, active site
1. PS00606 (B_KETOACYL...)
  
  14 - 30
  
  PROSITE patterns
  PS00606 (B_KETOACYL_SYNTHASE)

no IPR

Unintegrated signatures

SM00822 (PKS_KR)

1,618 - 1,799

SMART
SM00822 (PKS_KR)
cd00833 (PKS)

1 - 266

CDD
cd00833 (PKS)
cd05195 (enoyl_red)

1,292 - 1,586

CDD
cd05195 (enoyl_red)
cd08954 (KR_1_FAS_S...)

1,634 - 1,846

CDD
cd08954 (KR_1_FAS_SDR_x)

Residue annotation

active site cd00833

23C

active site
23C, 155H, 193H
CDD
cd00833 (PKS)

155H

active site
23C, 155H, 193H
CDD
cd00833 (PKS)

193H

active site
23C, 155H, 193H
CDD
cd00833 (PKS)
NAD(P) binding sit...

1,305F

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,386T

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,407A

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,409S

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,410G

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,411G

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,412V

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,431V

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,432G

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,436K

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,455S

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,456R

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,479S

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,501I

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,526I

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,527M

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,528L

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,575M

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,576A

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,578G

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)

1,580H

NAD(P) binding site
1,305F, 1,386T, 1,407A, 1,409S, 1,410G, 1,411G, 1,412V, 1,431V, 1,432G, 1,436K, 1,455S, 1,456R, 1,479S, 1,501I, 1,526I, 1,527M, 1,528L, 1,575M, 1,576A, 1,578G, 1,580H
CDD
cd05195 (enoyl_red)
putative NADP bind...

1,649S

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,650R

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,651R

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,652G

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,677H

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,678D

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,679I

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,680T

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,704L

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,705A

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,706V

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,727P

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,728K

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,752F

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,753S

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,767Y

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,794G

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)

1,795A

putative NADP binding site
1,649S, 1,650R, 1,651R, 1,652G, 1,677H, 1,678D, 1,679I, 1,680T, 1,704L, 1,705A, 1,706V, 1,727P, 1,728K, 1,752F, 1,753S, 1,767Y, 1,794G, 1,795A
CDD
cd08954 (KR_1_FAS_SDR_x)
active site cd08954

1,728K

active site
1,728K, 1,754S, 1,767Y, 1,771N
CDD
cd08954 (KR_1_FAS_SDR_x)

1,754S

active site
1,728K, 1,754S, 1,767Y, 1,771N
CDD
cd08954 (KR_1_FAS_SDR_x)

1,767Y

active site
1,728K, 1,754S, 1,767Y, 1,771N
CDD
cd08954 (KR_1_FAS_SDR_x)

1,771N

active site
1,728K, 1,754S, 1,767Y, 1,771N
CDD
cd08954 (KR_1_FAS_SDR_x)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0031177 phosphopantetheine binding

Cellular Component