KWMTBOMO09285

Protein

Length

1,180 amino acids

Protein family membership

Adenylate cyclase (IPR030672)

Domains and repeats

Domain
23 - 192
Adenylate cyclase, N-terminal (IPR032628)
Domain
166 - 391
Nucleotide cyclase (IPR029787)
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054)
426 - 517
Adenylate cyclase, conserved domain (IPR009398)
756 - 981
Nucleotide cyclase (IPR029787)
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054)

1 200 400 600 800 1000 1180

Detailed signature matches

IPR030672

Adenylate cyclase
1. PIRSF039050 (Ade_cyc)
  
  1 - 984
  
  PIRSF
  PIRSF039050 (Ade_cyc)
IPR032628

Adenylate cyclase, N-terminal
1. PF16214 (AC_N)
  
  23 - 192
  
  Pfam
  PF16214 (AC_N)
IPR029787

Nucleotide cyclase
1. SSF55073 (Nucleotid...)
  
  792 - 977
  
  SUPERFAMILY
  SSF55073 (Nucleotide cyclase)
  
  202 - 368
  
  SUPERFAMILY
  SSF55073 (Nucleotide cyclase)
IPR001054

Adenylyl cyclase class-3/4/guanylyl cyclase
1. PS50125 (GUANYLATE_...)
  
  796 - 932
  
  PROSITE profiles
  PS50125 (GUANYLATE_CYCLASE_2)
  
  215 - 342
  
  PROSITE profiles
  PS50125 (GUANYLATE_CYCLASE_2)
2. SM00044 (cyc_6)
  
  166 - 368
  
  SMART
  SM00044 (cyc_6)
  
  756 - 961
  
  SMART
  SM00044 (cyc_6)
3. G3DSA:3.30.70...
  
  201 - 391
  
  GENE3D
  G3DSA:3.30.70.1230 (G3DSA:3.30.70.1230)
  
  785 - 981
  
  GENE3D
  G3DSA:3.30.70.1230 (G3DSA:3.30.70.1230)
4. PF00211 (Guanylate_cyc)
  
  788 - 976
  
  Pfam
  PF00211 (Guanylate_cyc)
  
  207 - 370
  
  Pfam
  PF00211 (Guanylate_cyc)
IPR009398

Adenylate cyclase, conserved domain
1. PF06327 (DUF1053)
  
  426 - 517
  
  Pfam
  PF06327 (DUF1053)
IPR018297

Adenylyl cyclase class-4/guanylyl cyclase, conserved site
1. PS00452 (GUANYLATE_...)
  
  909 - 932
  
  PROSITE patterns
  PS00452 (GUANYLATE_CYCLASE_1)

no IPR

Unintegrated signatures

cd07302 (CHD)

213 - 388

CDD
cd07302 (CHD)

794 - 976

CDD
cd07302 (CHD)
mobidb-lite (disord...)

1,021 - 1,137

MobiDB Lite
mobidb-lite (disorder_prediction)

418 - 439

MobiDB Lite
mobidb-lite (disorder_prediction)

1,149 - 1,180

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

nucleotidyl bindin...

218Y

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

220D

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

221I

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

222K

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

223G

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

224F

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

225T

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

260K

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

262L

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

263G

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

264D

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

267F

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

329D

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

330L

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

331W

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

335V

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

336T

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

339N

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)

340H

nucleotidyl binding site
218Y, 220D, 221I, 222K, 223G, 224F, 225T, 260K, 262L, 263G, 264D, 267F, 329D, 330L, 331W, 335V, 336T, 339N, 340H
CDD
cd07302 (CHD)
metal binding site...

220D

metal binding site
220D, 264D
CDD
cd07302 (CHD)

264D

metal binding site
220D, 264D
CDD
cd07302 (CHD)
dimer interface cd...

225T

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

237V

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

240L

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

241N

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

244F

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

248D

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

260K

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

261L

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

317L

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

320V

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

330L

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

331W

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

332S

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

333Y

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)

336T

dimer interface
225T, 237V, 240L, 241N, 244F, 248D, 260K, 261L, 317L, 320V, 330L, 331W, 332S, 333Y, 336T
CDD
cd07302 (CHD)
nucleotidyl bindin...

799F

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

801G

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

802I

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

803P

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

804N

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

805F

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

806H

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

844K

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

846I

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

847G

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

848A

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

851M

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

919D

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

920I

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

921W

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

925V

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

926N

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

929S

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

930R

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)

966K

nucleotidyl binding site
799F, 801G, 802I, 803P, 804N, 805F, 806H, 844K, 846I, 847G, 848A, 851M, 919D, 920I, 921W, 925V, 926N, 929S, 930R, 966K
CDD
cd07302 (CHD)
metal binding site...

801G

metal binding site
801G, 848A
CDD
cd07302 (CHD)

848A

metal binding site
801G, 848A
CDD
cd07302 (CHD)
dimer interface cd...

806H

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

818M

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

821L

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

822N

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

825I

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

829D

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

844K

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

845T

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

907V

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

910V

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

920I

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

921W

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

922G

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

923N

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

926N

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

966K

dimer interface
806H, 818M, 821L, 822N, 825I, 829D, 844K, 845T, 907V, 910V, 920I, 921W, 922G, 923N, 926N, 966K
CDD
cd07302 (CHD)

GO term prediction

Biological Process

GO:0006171 cAMP biosynthetic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004016 adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity

Cellular Component

GO:0005886 plasma membrane

Filter view on

Entry type

Status

Per-residue features