KWMTBOMO09213

Protein

Length

480 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
120 - 188
Winged helix-turn-helix DNA-binding domain (IPR011991)
E2F/DP family, winged-helix DNA-binding domain (IPR003316)
203 - 299
E2F transcription factor, CC-MB domain (IPR032198)

1 50 100 150 200 250 300 350 400 450 480

Detailed signature matches

IPR011991

Winged helix-turn-helix DNA-binding domain
1. G3DSA:1.10.10.10
  
  120 - 187
  
  GENE3D
  G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
2. SSF46785 ("Winged h...)
  
  123 - 186
  
  SUPERFAMILY
  SSF46785 ("Winged helix" DNA-binding domain)
IPR003316

E2F/DP family, winged-helix DNA-binding domain
1. PF02319 (E2F_TDP)
  
  125 - 187
  
  Pfam
  PF02319 (E2F_TDP)
2. SM01372 (E2F_TDP_2)
  
  123 - 188
  
  SMART
  SM01372 (E2F_TDP_2)
IPR032198

E2F transcription factor, CC-MB domain
1. cd14660 (E2F_DD)
  
  203 - 299
  
  CDD
  cd14660 (E2F_DD)
2. PF16421 (E2F_CC-MB)
  
  205 - 297
  
  Pfam
  PF16421 (E2F_CC-MB)

no IPR

Unintegrated signatures

SSF144074 (E2F-DP h...)

203 - 299

SUPERFAMILY
SSF144074 (E2F-DP heterodimerization region)
mobidb-lite (disord...)

1 - 88

MobiDB Lite
mobidb-lite (disorder_prediction)

371 - 409

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

heterodimer interf...

205L

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

206R

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

208E

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

209V

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

212L

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

213S

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

215R

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

216E

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

219V

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

220S

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

222A

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

223V

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

225A

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

226A

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

227E

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

229A

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

230L

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

233L

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

239A

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

240K

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

241A

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

242Y

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

243I

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

244T

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

247D

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

248L

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

251I

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

255R

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

256N

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

257Q

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

258T

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

259V

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

260I

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

261P

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

262I

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

263K

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

279G

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

280Y

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

281M

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

282I

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

283H

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

284L

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

285K

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

286S

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

288S

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

289G

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

290E

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

291I

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

293V

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)

299E

heterodimer interface
205L, 206R, 208E, 209V, 212L, 213S, 215R, 216E, 219V, 220S, 222A, 223V, 225A, 226A, 227E, 229A, 230L, 233L, 239A, 240K, 241A, 242Y, 243I, 244T, 247D, 248L, 251I, 255R, 256N, 257Q, 258T, 259V, 260I, 261P, 262I, 263K, 279G, 280Y, 281M, 282I, 283H, 284L, 285K, 286S, 288S, 289G, 290E, 291I, 293V, 299E
CDD
cd14660 (E2F_DD)
RbC binding site c...

265P

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

266P

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

267D

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

268T

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

269R

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

270L

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

271S

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

272V

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

273P

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

274H

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

276D

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

277E

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

280Y

RbC binding site
265P, 266P, 267D, 268T, 269R, 270L, 271S, 272V, 273P, 274H, 276D, 277E, 280Y
CDD
cd14660 (E2F_DD)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046983 protein dimerization activity

Cellular Component

GO:0005667 transcription factor complex

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Entry type

Status

Per-residue features