KWMTBOMO09055

Protein

Length

1,047 amino acids

Protein family membership

NAD(P) transhydrogenase, alpha subunit (IPR026255)

NADP transhydrogenase, beta subunit (IPR012136)

Domains and repeats

Domain
44 - 177
Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal (IPR007886)
181 - 405
Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain (IPR007698)
Domain
177 - 356
NAD(P)-binding domain (IPR016040)
466 - 551
NAD(P) transhydrogenase, alpha subunit, C-terminal (IPR024605)
833 - 859
NAD(P)-binding domain (IPR016040)
869 - 1,044
DHS-like NAD/FAD-binding domain (IPR029035)

1 100 200 300 400 500 600 700 800 900 1047

Detailed signature matches

IPR026255

NAD(P) transhydrogenase, alpha subunit
1. TIGR00561
  
  43 - 551
  
  TIGRFAMs
  TIGR00561 (TIGR00561)
IPR012136

NADP transhydrogenase, beta subunit
1. PF02233 (PNTB)
  
  586 - 1,040
  
  Pfam
  PF02233 (PNTB)
IPR007886

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
1. PF05222 (AlaDh_PNT_N)
  
  44 - 177
  
  Pfam
  PF05222 (AlaDh_PNT_N)
2. SM01003 (AlaDh_PNT_N_2)
  
  44 - 177
  
  SMART
  SM01003 (AlaDh_PNT_N_2)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  177 - 356
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  833 - 859
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
  
  216 - 237
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR007698

Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
1. SM01002 (AlaDh_PNT_C_2)
  
  186 - 350
  
  SMART
  SM01002 (AlaDh_PNT_C_2)
2. PF01262 (AlaDh_PNT_C)
  
  181 - 405
  
  Pfam
  PF01262 (AlaDh_PNT_C)
IPR024605

NAD(P) transhydrogenase, alpha subunit, C-terminal
1. PF12769 (PNTB_4TM)
  
  466 - 551
  
  Pfam
  PF12769 (PNTB_4TM)
IPR029035

DHS-like NAD/FAD-binding domain
1. G3DSA:3.40.50...
  
  869 - 1,044
  
  GENE3D
  G3DSA:3.40.50.1220 (G3DSA:3.40.50.1220)
2. SSF52467 (DHS-like ...)
  
  871 - 1,044
  
  SUPERFAMILY
  SSF52467 (DHS-like NAD/FAD-binding domain)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

42 - 215

GENE3D
G3DSA:3.40.50.1770 (G3DSA:3.40.50.1770)

238 - 407

GENE3D
G3DSA:3.40.50.1770 (G3DSA:3.40.50.1770)
SSF52283 (Formate/g...)

43 - 208

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd05304 (Rubrum_tdh)

41 - 401

CDD
cd05304 (Rubrum_tdh)
mobidb-lite (disord...)

408 - 428

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ligand binding sit...

55R

ligand binding site
55R, 113R, 132F, 327E, 353D, 355P
CDD
cd05304 (Rubrum_tdh)

113R

ligand binding site
55R, 113R, 132F, 327E, 353D, 355P
CDD
cd05304 (Rubrum_tdh)

132F

ligand binding site
55R, 113R, 132F, 327E, 353D, 355P
CDD
cd05304 (Rubrum_tdh)

327E

ligand binding site
55R, 113R, 132F, 327E, 353D, 355P
CDD
cd05304 (Rubrum_tdh)

353D

ligand binding site
55R, 113R, 132F, 327E, 353D, 355P
CDD
cd05304 (Rubrum_tdh)

355P

ligand binding site
55R, 113R, 132F, 327E, 353D, 355P
CDD
cd05304 (Rubrum_tdh)
homodimer interfac...

84N

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

165Q

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

166A

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

175N

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

176V

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

179Y

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

180R

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

183I

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

184E

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

186A

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

187A

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

189F

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

190P

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

191R

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

192F

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

193F

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

194S

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

196Q

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

198T

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

199A

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

200A

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

203V

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

226C

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

227M

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

317P

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

318G

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

360A

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

361H

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

365L

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

368N

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)

369N

homodimer interface
84N, 165Q, 166A, 175N, 176V, 179Y, 180R, 183I, 184E, 186A, 187A, 189F, 190P, 191R, 192F, 193F, 194S, 196Q, 198T, 199A, 200A, 203V, 226C, 227M, 317P, 318G, 360A, 361H, 365L, 368N, 369N
CDD
cd05304 (Rubrum_tdh)
NAD(P) binding sit...

160R

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

161I

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

165Q

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

168D

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

171S

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

235D

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

236T

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

237R

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

267A

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

278E

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

295T

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

296A

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

297L

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

304P

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)

306L

NAD(P) binding site
160R, 161I, 165Q, 168D, 171S, 235D, 236T, 237R, 267A, 278E, 295T, 296A, 297L, 304P, 306L
CDD
cd05304 (Rubrum_tdh)
trimer interface B...

162S

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

163R

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

165Q

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

175N

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

226C

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

242E

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

243Q

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

245E

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

246S

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

247L

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)

248G

trimer interface B
162S, 163R, 165Q, 175N, 226C, 242E, 243Q, 245E, 246S, 247L, 248G
CDD
cd05304 (Rubrum_tdh)
trimer interface A...

195G

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

196Q

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

197M

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

198T

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

199A

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

202R

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

205P

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

228G

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

230A

trimer interface A
195G, 196Q, 197M, 198T, 199A, 202R, 205P, 228G, 230A
CDD
cd05304 (Rubrum_tdh)

GO term prediction

Biological Process

GO:0015992 proton transport
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008746 NAD(P)+ transhydrogenase activity
GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity
GO:0050661 NADP binding

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features