KWMTBOMO08246

Protein

Length

855 amino acids

Protein family membership

DNA topoisomerase, type IA (IPR000380)

Domains and repeats

Domain
3 - 172
Toprim domain (IPR006171)
177 - 231
DNA topoisomerase, type IA, central region, subdomain 1 (IPR013824)
297 - 419
DNA topoisomerase, type IA, central region, subdomain 3 (IPR013826)
489 - 595
DNA topoisomerase, type IA, central region, subdomain 1 (IPR013824)
Domain
4 - 595
DNA topoisomerase, type IA, core domain (IPR023405)
Domain
145 - 241
DNA topoisomerase, type IA, domain 2 (IPR003601)
288 - 544
DNA topoisomerase, type IA, DNA-binding domain (IPR003602)
Domain
169 - 592
DNA topoisomerase, type IA, central (IPR013497)

1 100 200 300 400 500 600 700 800 855

Detailed signature matches

IPR000380

DNA topoisomerase, type IA
1. PR00417 (PRTPISMRASEI)
  
  506 - 520
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  111 - 124
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  211 - 229
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  330 - 339
  
  PRINTS
  PR00417 (PRTPISMRASEI)
  
  407 - 423
  
  PRINTS
  PR00417 (PRTPISMRASEI)
IPR006171

Toprim domain
1. SM00493 (toprim5)
  
  3 - 137
  
  SMART
  SM00493 (toprim5)
2. PS50880 (TOPRIM)
  
  3 - 156
  
  PROSITE profiles
  PS50880 (TOPRIM)
3. G3DSA:3.40.50...
  
  4 - 172
  
  GENE3D
  G3DSA:3.40.50.140 (G3DSA:3.40.50.140)
4. PF01751 (Toprim)
  
  5 - 138
  
  Pfam
  PF01751 (Toprim)
IPR023405

DNA topoisomerase, type IA, core domain
1. SSF56712 (Prokaryot...)
  
  4 - 595
  
  SUPERFAMILY
  SSF56712 (Prokaryotic type I DNA topoisomerase)
IPR003601

DNA topoisomerase, type IA, domain 2
1. SM00436 (topIban2)
  
  145 - 241
  
  SMART
  SM00436 (topIban2)
IPR013497

DNA topoisomerase, type IA, central
1. cd00186 (TOP1Ac)
  
  171 - 592
  
  CDD
  cd00186 (TOP1Ac)
2. PF01131 (Topoisom_bac)
  
  169 - 581
  
  Pfam
  PF01131 (Topoisom_bac)
IPR013824

DNA topoisomerase, type IA, central region, subdomain 1
1. G3DSA:1.10.46...
  
  489 - 595
  
  GENE3D
  G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
  
  177 - 231
  
  GENE3D
  G3DSA:1.10.460.10 (G3DSA:1.10.460.10)
IPR003602

DNA topoisomerase, type IA, DNA-binding domain
1. SM00437 (topIaneu2)
  
  288 - 544
  
  SMART
  SM00437 (topIaneu2)
IPR013826

DNA topoisomerase, type IA, central region, subdomain 3
1. G3DSA:1.10.29...
  
  297 - 419
  
  GENE3D
  G3DSA:1.10.290.10 (G3DSA:1.10.290.10)
IPR023406

DNA topoisomerase, type IA, active site
1. PS00396 (TOPOISOMER...)
  
  325 - 339
  
  PROSITE patterns
  PS00396 (TOPOISOMERASE_I_PROK)

no IPR

Unintegrated signatures

cd03362 (TOPRIM_Top...)

3 - 166

CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
mobidb-lite (disord...)

819 - 840

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd03362

9E

active site
9E, 10K, 13L, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

10K

active site
9E, 10K, 13L, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

13L

active site
9E, 10K, 13L, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

116D

active site
9E, 10K, 13L, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

118D

active site
9E, 10K, 13L, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

120E

active site
9E, 10K, 13L, 116D, 118D, 120E
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
putative interdoma...

16N

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

117C

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

119K

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

126F

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

127E

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

129M

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

130S

putative interdomain interaction site
16N, 117C, 119K, 126F, 127E, 129M, 130S
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
putative metal-bin...

116D

putative metal-binding site
116D, 118D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)

118D

putative metal-binding site
116D, 118D
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
putative nucleotid...

119K

putative nucleotide binding site
119K
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)
domain I cd00186

171E

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

172N

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

173Q

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

174S

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

175R

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

176S

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

177V

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

178D

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

179A

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

180R

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

181Q

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

182E

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

183L

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

184D

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

185L

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

186R

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

187I

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

188G

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

189C

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

190A

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

191F

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

192T

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

193R

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

194F

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

195Q

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

196T

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

197K

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

198Y

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

211I

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

212S

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

213Y

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

214G

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

215P

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

216C

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

217Q

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

218T

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

219P

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

220T

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

221L

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

222G

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

223F

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

224C

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

225V

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

226Q

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

227R

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

228H

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

229D

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

230E

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)

231I

domain I
171E, 172N, 173Q, 174S, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198Y, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230E, 231I
CDD
cd00186 (TOP1Ac)
DNA binding groove...

180R

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

181Q

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

184D

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

188G

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

192T

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

325E

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

329T

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

337R

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

511A

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

512S

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

515V

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

516H

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

518N

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

522Q

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)

523R

DNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 511A, 512S, 515V, 516H, 518N, 522Q, 523R
CDD
cd00186 (TOP1Ac)
phosphate binding ...

222G

phosphate binding site
222G, 226Q, 548Q
CDD
cd00186 (TOP1Ac)

226Q

phosphate binding site
222G, 226Q, 548Q
CDD
cd00186 (TOP1Ac)

548Q

phosphate binding site
222G, 226Q, 548Q
CDD
cd00186 (TOP1Ac)
domain II cd00186

236P

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

237E

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

238T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

239Y

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

240W

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

241V

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

242L

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

280K

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

281E

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

282A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

283T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

284V

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

285I

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

286N

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

287I

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

288Q

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

289A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

290K

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

291E

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

292K

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

293V

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

294K

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

295A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

421R

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

422D

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

423C

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

424K

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

425F

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

426L

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

427S

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

428T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

429T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

430I

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

431T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

432F

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

433R

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

434I

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

435A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

437E

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

438T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

439F

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

440H

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

441Y

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

442T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

443G

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

444N

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

445A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

446L

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

447L

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

448D

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

449A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

450G

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

451Y

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

452T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

453E

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

454L

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

455M

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

478H

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

479D

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

480H

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

481R

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

482L

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

483V

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

484E

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

485C

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

486Q

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

487T

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)

488A

domain II
236P, 237E, 238T, 239Y, 240W, 241V, 242L, 280K, 281E, 282A, 283T, 284V, 285I, 286N, 287I, 288Q, 289A, 290K, 291E, 292K, 293V, 294K, 295A, 421R, 422D, 423C, 424K, 425F, 426L, 427S, 428T, 429T, 430I, 431T, 432F, 433R, 434I, 435A, 437E, 438T, 439F, 440H, 441Y, 442T, 443G, 444N, 445A, 446L, 447L, 448D, 449A, 450G, 451Y, 452T, 453E, 454L, 455M, 478H, 479D, 480H, 481R, 482L, 483V, 484E, 485C, 486Q, 487T, 488A
CDD
cd00186 (TOP1Ac)
domain III cd00186

296R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

297P

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

298T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

299A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

300L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

301N

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

302T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

304E

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

305L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

306M

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

307R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

308V

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

309A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

310S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

311A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

312G

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

313L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

314G

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

315M

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

316G

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

317P

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

318H

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

319H

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

320A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

321M

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

322A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

323V

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

324A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

325E

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

326R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

327L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

328Y

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

329T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

330Q

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

331G

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

332Y

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

333I

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

334S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

335Y

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

336P

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

337R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

338T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

339E

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

340T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

341T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

342S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

343Y

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

344S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

345E

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

346N

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

347F

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

348D

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

349L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

350M

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

351G

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

352T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

353L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

354R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

355Q

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

356Q

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

357Q

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

358S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

359S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

385D

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

386H

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

387P

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

388P

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

389I

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

390T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

391P

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

400L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

401E

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

402G

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

403D

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

404M

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

405W

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

406R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

407I

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

408Y

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

409D

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

410Y

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

411V

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

412T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

413R

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

414H

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

415F

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

416I

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

417A

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

418T

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

419L

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)

420S

domain III
296R, 297P, 298T, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311A, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322A, 323V, 324A, 325E, 326R, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342S, 343Y, 344S, 345E, 346N, 347F, 348D, 349L, 350M, 351G, 352T, 353L, 354R, 355Q, 356Q, 357Q, 358S, 359S, 385D, 386H, 387P, 388P, 389I, 390T, 391P, 400L, 401E, 402G, 403D, 404M, 405W, 406R, 407I, 408Y, 409D, 410Y, 411V, 412T, 413R, 414H, 415F, 416I, 417A, 418T, 419L, 420S
CDD
cd00186 (TOP1Ac)
nucleotide binding...

307R

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

311A

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

312G

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

313L

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

386H

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

406R

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

409D

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

413R

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

509T

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

511A

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)

534L

nucleotide binding site
307R, 311A, 312G, 313L, 386H, 406R, 409D, 413R, 509T, 511A, 534L
CDD
cd00186 (TOP1Ac)
catalytic site cd0...

335Y

catalytic site
335Y, 337R, 386H
CDD
cd00186 (TOP1Ac)

337R

catalytic site
335Y, 337R, 386H
CDD
cd00186 (TOP1Ac)

386H

catalytic site
335Y, 337R, 386H
CDD
cd00186 (TOP1Ac)
domain IV cd00186

489P

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

490P

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

491D

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

492Y

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

493L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

494T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

495E

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

496S

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

497E

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

498V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

499I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

500T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

501L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

502M

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

503E

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

504K

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

505H

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

506G

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

507I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

508G

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

509T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

510D

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

511A

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

512S

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

513I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

514P

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

515V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

516H

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

517I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

518N

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

519N

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

520I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

521C

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

522Q

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

523R

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

524N

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

525Y

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

526V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

527T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

528V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

530S

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

534L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

535V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

536P

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

537T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

538N

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

539L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

540G

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

541I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

542V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

543L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

544V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

545H

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

546G

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

547Y

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

548Q

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

554L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

555V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

556L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

557P

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

558T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

559M

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

560R

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

561S

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

562A

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

563V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

564E

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

565E

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

566Q

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

567L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

568N

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

569L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

570I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

571A

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

572V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

573G

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

574R

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

575A

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

576D

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

577F

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

578H

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

579A

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

580V

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

581L

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

582S

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

583H

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

584T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

585T

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

586E

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

587I

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

588F

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

589R

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

590R

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

591K

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

592F

domain IV
489P, 490P, 491D, 492Y, 493L, 494T, 495E, 496S, 497E, 498V, 499I, 500T, 501L, 502M, 503E, 504K, 505H, 506G, 507I, 508G, 509T, 510D, 511A, 512S, 513I, 514P, 515V, 516H, 517I, 518N, 519N, 520I, 521C, 522Q, 523R, 524N, 525Y, 526V, 527T, 528V, 530S, 534L, 535V, 536P, 537T, 538N, 539L, 540G, 541I, 542V, 543L, 544V, 545H, 546G, 547Y, 548Q, 554L, 555V, 556L, 557P, 558T, 559M, 560R, 561S, 562A, 563V, 564E, 565E, 566Q, 567L, 568N, 569L, 570I, 571A, 572V, 573G, 574R, 575A, 576D, 577F, 578H, 579A, 580V, 581L, 582S, 583H, 584T, 585T, 586E, 587I, 588F, 589R, 590R, 591K, 592F
CDD
cd00186 (TOP1Ac)

GO term prediction

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features