KWMTBOMO08024

Protein

Length

375 amino acids

Protein family membership

Exosome complex component RRP45 (IPR033100)

Domains and repeats

Domain
1 - 168
Ribosomal protein S5 domain 2-type fold (IPR020568)
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
200 - 214
Ribosomal protein S5 domain 2-type fold (IPR020568)
Domain
11 - 153
PNPase/RNase PH domain (IPR027408)
188 - 304
Exoribonuclease, phosphorolytic domain 2 (IPR015847)

1 50 100 150 200 250 300 350 375

Detailed signature matches

IPR033100

Exosome complex component RRP45
1. cd11368 (RNase_PH_R...)
  
  6 - 274
  
  CDD
  cd11368 (RNase_PH_RRP45)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  1 - 168
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
  
  200 - 214
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR027408

PNPase/RNase PH domain
1. G3DSA:3.30.23...
  
  11 - 153
  
  GENE3D
  G3DSA:3.30.230.70 (G3DSA:3.30.230.70)
IPR001247

Exoribonuclease, phosphorolytic domain 1
1. PF01138 (RNase_PH)
  
  31 - 163
  
  Pfam
  PF01138 (RNase_PH)
IPR015847

Exoribonuclease, phosphorolytic domain 2
1. SSF55666 (Ribonucle...)
  
  188 - 304
  
  SUPERFAMILY
  SSF55666 (Ribonuclease PH domain 2-like)

Residue annotation

Rrp40 interface cd...

7S

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

8N

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

9C

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

12N

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

13F

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

17I

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

20Q

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)

22H

Rrp40 interface
7S, 8N, 9C, 12N, 13F, 17I, 20Q, 22H
CDD
cd11368 (RNase_PH_RRP45)
hexamer interface ...

41S

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

43Y

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

58E

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

60T

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

61C

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

62E

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

77F

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

79N

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

84P

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

101Y

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

104R

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

108K

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

130W

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

135N

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

140N

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

158A

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

159H

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

160F

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

190Y

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

241V

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

242C

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

243L

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

244L

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

245D

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

246L

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

247T

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

248G

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

249A

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

250A

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

251I

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

252Y

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

257V

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

261L

hexamer interface
41S, 43Y, 58E, 60T, 61C, 62E, 77F, 79N, 84P, 101Y, 104R, 108K, 130W, 135N, 140N, 158A, 159H, 160F, 190Y, 241V, 242C, 243L, 244L, 245D, 246L, 247T, 248G, 249A, 250A, 251I, 252Y, 257V, 261L
CDD
cd11368 (RNase_PH_RRP45)

GO term prediction

Biological Process

GO:0006396 RNA processing

Molecular Function

None predicted.

Cellular Component

GO:0000178 exosome (RNase complex)

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO08024

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component