KWMTBOMO07652

Protein

Length

1,771 amino acids

Protein family membership

Histone acetyltransferase Rtt109/CBP (IPR013178)

Domains and repeats

Domain
347 - 440
Zinc finger, TAZ-type (IPR000197)
558 - 644
Coactivator CBP, KIX domain (IPR003101)
935 - 1,058
Bromodomain (IPR001487)
1,558 - 1,601
Zinc finger, ZZ-type (IPR000433)
1,620 - 1,709
Zinc finger, TAZ-type (IPR000197)
Domain
1,049 - 1,135
CREB-binding protein/p300, atypical RING domain (IPR010303)
1,180 - 1,557
CBP/p300-type histone acetyltransferase domain (IPR031162)

1 200 400 600 800 1000 1200 1400 1600 1771

Detailed signature matches

IPR013178

Histone acetyltransferase Rtt109/CBP
1. PF08214 (HAT_KAT11)
  
  1,199 - 1,505
  
  Pfam
  PF08214 (HAT_KAT11)
2. SM01250 (KAT11_2)
  
  1,199 - 1,505
  
  SMART
  SM01250 (KAT11_2)
IPR000197

Zinc finger, TAZ-type
1. SM00551 (TAZ_2)
  
  350 - 436
  
  SMART
  SM00551 (TAZ_2)
  
  1,621 - 1,700
  
  SMART
  SM00551 (TAZ_2)
2. PS50134 (ZF_TAZ)
  
  349 - 436
  
  PROSITE profiles
  PS50134 (ZF_TAZ)
  
  1,621 - 1,702
  
  PROSITE profiles
  PS50134 (ZF_TAZ)
3. PF02135 (zf-TAZ)
  
  1,628 - 1,699
  
  Pfam
  PF02135 (zf-TAZ)
  
  356 - 433
  
  Pfam
  PF02135 (zf-TAZ)
4. G3DSA:1.20.10...
  
  1,621 - 1,709
  
  GENE3D
  G3DSA:1.20.1020.10 (G3DSA:1.20.1020.10)
  
  349 - 440
  
  GENE3D
  G3DSA:1.20.1020.10 (G3DSA:1.20.1020.10)
5. SSF57933 (TAZ domain)
  
  347 - 439
  
  SUPERFAMILY
  SSF57933 (TAZ domain)
  
  1,620 - 1,704
  
  SUPERFAMILY
  SSF57933 (TAZ domain)
IPR003101

Coactivator CBP, KIX domain
1. SSF47040 (Kix domai...)
  
  560 - 643
  
  SUPERFAMILY
  SSF47040 (Kix domain of CBP (creb binding protein))
2. PF02172 (KIX)
  
  560 - 638
  
  Pfam
  PF02172 (KIX)
3. G3DSA:1.10.24...
  
  560 - 644
  
  GENE3D
  G3DSA:1.10.246.20 (G3DSA:1.10.246.20)
4. PS50952 (KIX)
  
  558 - 637
  
  PROSITE profiles
  PS50952 (KIX)
IPR001487

Bromodomain
1. PS50014 (BROMODOMAIN_2)
  
  960 - 1,032
  
  PROSITE profiles
  PS50014 (BROMODOMAIN_2)
2. SM00297 (bromo_6)
  
  940 - 1,051
  
  SMART
  SM00297 (bromo_6)
3. SSF47370 (Bromodomain)
  
  935 - 1,054
  
  SUPERFAMILY
  SSF47370 (Bromodomain)
4. PF00439 (Bromodomain)
  
  956 - 1,036
  
  Pfam
  PF00439 (Bromodomain)
5. PR00503 (BROMODOMAIN)
  
  963 - 976
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,013 - 1,032
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  995 - 1,013
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  979 - 995
  
  PRINTS
  PR00503 (BROMODOMAIN)
6. G3DSA:1.20.92...
  
  946 - 1,058
  
  GENE3D
  G3DSA:1.20.920.10 (G3DSA:1.20.920.10)
IPR010303

CREB-binding protein/p300, atypical RING domain
1. PF06001 (DUF902)
  
  1,049 - 1,088
  
  Pfam
  PF06001 (DUF902)
2. cd15802 (RING_CBP-p300)
  
  1,063 - 1,135
  
  CDD
  cd15802 (RING_CBP-p300)
IPR031162

CBP/p300-type histone acetyltransferase domain
1. PS51727 (CBP_P300_HAT)
  
  1,180 - 1,557
  
  PROSITE profiles
  PS51727 (CBP_P300_HAT)
IPR000433

Zinc finger, ZZ-type
1. PS01357 (ZF_ZZ_1)
  
  1,564 - 1,589
  
  PROSITE patterns
  PS01357 (ZF_ZZ_1)
2. PF00569 (ZZ)
  
  1,559 - 1,599
  
  Pfam
  PF00569 (ZZ)
3. PS50135 (ZF_ZZ_2)
  
  1,558 - 1,601
  
  PROSITE profiles
  PS50135 (ZF_ZZ_2)
4. SM00291 (zz_5)
  
  1,558 - 1,599
  
  SMART
  SM00291 (zz_5)
IPR018359

Bromodomain, conserved site
1. PS00633 (BROMODOMAIN_1)
  
  965 - 1,024
  
  PROSITE patterns
  PS00633 (BROMODOMAIN_1)

no IPR

Unintegrated signatures

Coil

629 - 671

COILS
Coil (Coil)

891 - 919

COILS
Coil (Coil)

1,405 - 1,432

COILS
Coil (Coil)
SSF57850 (RING/U-box)

1,541 - 1,599

SUPERFAMILY
SSF57850 (RING/U-box)
cd02337 (ZZ_CBP)

1,562 - 1,602

CDD
cd02337 (ZZ_CBP)
cd05495 (Bromo_cbp_...)

944 - 1,051

CDD
cd05495 (Bromo_cbp_like)
cd15557 (PHD_CBP_p300)

1,137 - 1,168

CDD
cd15557 (PHD_CBP_p300)
mobidb-lite (disord...)

1,412 - 1,472

MobiDB Lite
mobidb-lite (disorder_prediction)

730 - 884

MobiDB Lite
mobidb-lite (disorder_prediction)

1,727 - 1,755

MobiDB Lite
mobidb-lite (disorder_prediction)

244 - 348

MobiDB Lite
mobidb-lite (disorder_prediction)

96 - 126

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 78

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

acetyllysine bindi...

972V

acetyllysine binding site
972V, 979I, 982Y, 1,021A, 1,025N, 1,031V
CDD
cd05495 (Bromo_cbp_like)

979I

acetyllysine binding site
972V, 979I, 982Y, 1,021A, 1,025N, 1,031V
CDD
cd05495 (Bromo_cbp_like)

982Y

acetyllysine binding site
972V, 979I, 982Y, 1,021A, 1,025N, 1,031V
CDD
cd05495 (Bromo_cbp_like)

1,021A

acetyllysine binding site
972V, 979I, 982Y, 1,021A, 1,025N, 1,031V
CDD
cd05495 (Bromo_cbp_like)

1,025N

acetyllysine binding site
972V, 979I, 982Y, 1,021A, 1,025N, 1,031V
CDD
cd05495 (Bromo_cbp_like)

1,031V

acetyllysine binding site
972V, 979I, 982Y, 1,021A, 1,025N, 1,031V
CDD
cd05495 (Bromo_cbp_like)
HAT interface cd15...

1,063F

HAT interface
1,063F, 1,066Q, 1,067V, 1,133E, 1,135E
CDD
cd15802 (RING_CBP-p300)

1,066Q

HAT interface
1,063F, 1,066Q, 1,067V, 1,133E, 1,135E
CDD
cd15802 (RING_CBP-p300)

1,067V

HAT interface
1,063F, 1,066Q, 1,067V, 1,133E, 1,135E
CDD
cd15802 (RING_CBP-p300)

1,133E

HAT interface
1,063F, 1,066Q, 1,067V, 1,133E, 1,135E
CDD
cd15802 (RING_CBP-p300)

1,135E

HAT interface
1,063F, 1,066Q, 1,067V, 1,133E, 1,135E
CDD
cd15802 (RING_CBP-p300)
Zn binding site cd...

1,070C

Zn binding site
1,070C, 1,076C, 1,094C, 1,097C
CDD
cd15802 (RING_CBP-p300)

1,076C

Zn binding site
1,070C, 1,076C, 1,094C, 1,097C
CDD
cd15802 (RING_CBP-p300)

1,094C

Zn binding site
1,070C, 1,076C, 1,094C, 1,097C
CDD
cd15802 (RING_CBP-p300)

1,097C

Zn binding site
1,070C, 1,076C, 1,094C, 1,097C
CDD
cd15802 (RING_CBP-p300)
putative histone H...

1,137F

putative histone H3 binding site
1,137F, 1,138V, 1,139M, 1,140C, 1,144G, 1,163F
CDD
cd15557 (PHD_CBP_p300)

1,138V

putative histone H3 binding site
1,137F, 1,138V, 1,139M, 1,140C, 1,144G, 1,163F
CDD
cd15557 (PHD_CBP_p300)

1,139M

putative histone H3 binding site
1,137F, 1,138V, 1,139M, 1,140C, 1,144G, 1,163F
CDD
cd15557 (PHD_CBP_p300)

1,140C

putative histone H3 binding site
1,137F, 1,138V, 1,139M, 1,140C, 1,144G, 1,163F
CDD
cd15557 (PHD_CBP_p300)

1,144G

putative histone H3 binding site
1,137F, 1,138V, 1,139M, 1,140C, 1,144G, 1,163F
CDD
cd15557 (PHD_CBP_p300)

1,163F

putative histone H3 binding site
1,137F, 1,138V, 1,139M, 1,140C, 1,144G, 1,163F
CDD
cd15557 (PHD_CBP_p300)
zinc cluster 1 cd0...

1,564C

zinc cluster 1
1,564C, 1,567C, 1,586C, 1,589C
CDD
cd02337 (ZZ_CBP)

1,567C

zinc cluster 1
1,564C, 1,567C, 1,586C, 1,589C
CDD
cd02337 (ZZ_CBP)

1,586C

zinc cluster 1
1,564C, 1,567C, 1,586C, 1,589C
CDD
cd02337 (ZZ_CBP)

1,589C

zinc cluster 1
1,564C, 1,567C, 1,586C, 1,589C
CDD
cd02337 (ZZ_CBP)
Zinc-binding sites...

1,564C

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,567C

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,577C

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,580C

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,586C

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,589C

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,595H

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,597H

Zinc-binding sites
1,564C, 1,567C, 1,577C, 1,580C, 1,586C, 1,589C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)
putative charged b...

1,565N

putative charged binding surface
1,565N, 1,574R, 1,576H, 1,582D, 1,584D
CDD
cd02337 (ZZ_CBP)

1,574R

putative charged binding surface
1,565N, 1,574R, 1,576H, 1,582D, 1,584D
CDD
cd02337 (ZZ_CBP)

1,576H

putative charged binding surface
1,565N, 1,574R, 1,576H, 1,582D, 1,584D
CDD
cd02337 (ZZ_CBP)

1,582D

putative charged binding surface
1,565N, 1,574R, 1,576H, 1,582D, 1,584D
CDD
cd02337 (ZZ_CBP)

1,584D

putative charged binding surface
1,565N, 1,574R, 1,576H, 1,582D, 1,584D
CDD
cd02337 (ZZ_CBP)
putative hydrophob...

1,575Y

putative hydrophobic binding surface
1,575Y, 1,590Y, 1,599M, 1,602L
CDD
cd02337 (ZZ_CBP)

1,590Y

putative hydrophobic binding surface
1,575Y, 1,590Y, 1,599M, 1,602L
CDD
cd02337 (ZZ_CBP)

1,599M

putative hydrophobic binding surface
1,575Y, 1,590Y, 1,599M, 1,602L
CDD
cd02337 (ZZ_CBP)

1,602L

putative hydrophobic binding surface
1,575Y, 1,590Y, 1,599M, 1,602L
CDD
cd02337 (ZZ_CBP)
zinc cluster 2 cd0...

1,577C

zinc cluster 2
1,577C, 1,580C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,580C

zinc cluster 2
1,577C, 1,580C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,595H

zinc cluster 2
1,577C, 1,580C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

1,597H

zinc cluster 2
1,577C, 1,580C, 1,595H, 1,597H
CDD
cd02337 (ZZ_CBP)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation

Molecular Function

GO:0003712 transcription cofactor activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding

Cellular Component

GO:0005634 nucleus

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Entry type

Status

Per-residue features