KWMTBOMO07421

Protein

Length

1,224 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
357 - 444
Aspartic peptidase domain (IPR021109)
608 - 790
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1224

Detailed signature matches

IPR021109

Aspartic peptidase domain
1. SSF50630 (Acid prot...)
  
  357 - 444
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  629 - 790
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  608 - 790
  
  PROSITE profiles
  PS50878 (RT_POL)

no IPR

Unintegrated signatures

Coil

118 - 138

COILS
Coil (Coil)
G3DSA:3.10.10.10

585 - 708

GENE3D
G3DSA:3.10.10.10 (G3DSA:3.10.10.10)
G3DSA:3.30.70...

709 - 792

GENE3D
G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
SSF56672 (DNA/RNA p...)

552 - 988

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

345 - 439

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

613 - 790

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

884 - 1,004

CDD
cd09274 (RNase_HI_RT_Ty3)

Residue annotation

Catalytic residue ...

362D

Catalytic residue
362D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

362D

catalytic motif
362D, 363S, 364G
CDD
cd00303 (retropepsin_like)

363S

catalytic motif
362D, 363S, 364G
CDD
cd00303 (retropepsin_like)

364G

catalytic motif
362D, 363S, 364G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

362D

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)

364G

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)

366N

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)

388V

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)

392K

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)

393T

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)

432L

inhibitor binding site
362D, 364G, 366N, 388V, 392K, 393T, 432L
CDD
cd00303 (retropepsin_like)
Active site flap c...

388V

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

392K

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

393T

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

394I

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

398K

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

399K

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

400T

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)

401K

Active site flap
388V, 392K, 393T, 394I, 398K, 399K, 400T, 401K
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

676D

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

677I

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

678N

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

679S

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

680A

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

681F

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

710F

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)

741D

putative NTP binding site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 741D
CDD
cd01647 (RT_LTR)
putative active si...

676D

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

677I

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

678N

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

679S

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

680A

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

681F

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

710F

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

711G

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

739F

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

741D

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

742D

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

786L

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)

787G

putative active site
676D, 677I, 678N, 679S, 680A, 681F, 710F, 711G, 739F, 741D, 742D, 786L, 787G
CDD
cd01647 (RT_LTR)
putative nucleic a...

711G

putative nucleic acid binding site
711G
CDD
cd01647 (RT_LTR)
active site cd09274

888D

active site
888D, 930E, 955D, 998D
CDD
cd09274 (RNase_HI_RT_Ty3)

930E

active site
888D, 930E, 955D, 998D
CDD
cd09274 (RNase_HI_RT_Ty3)

955D

active site
888D, 930E, 955D, 998D
CDD
cd09274 (RNase_HI_RT_Ty3)

998D

active site
888D, 930E, 955D, 998D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

888D

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

889A

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

890S

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

891I

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

925K

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

926A

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

927I

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

930E

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

955D

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

988Y

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,002R

RNA/DNA hybrid binding site
888D, 889A, 890S, 891I, 925K, 926A, 927I, 930E, 955D, 988Y, 1,002R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO07421

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component