KWMTBOMO07126

Protein

Length

1,586 amino acids

Protein family membership

Smooth muscle protein/calponin (IPR003096)
- Calponin/LIMCH1 (IPR001997)

Domains and repeats

Domain
275 - 345
Pre-C2HC domain (IPR006579)
347 - 360
Zinc finger, CCHC-type (IPR001878)
543 - 755
Endonuclease/exonuclease/phosphatase (IPR005135)
1,018 - 1,304
Reverse transcriptase domain (IPR000477)
1,420 - 1,575
Calponin homology domain (IPR001715)
Repeat
1,562 - 1,586
Calponin repeat (IPR000557)

1 200 400 600 800 1000 1200 1400 1586

Detailed signature matches

IPR003096

Smooth muscle protein/calponin
1. PR00888 (SM22CALPONIN)
  
  1,421 - 1,434
  
  PRINTS
  PR00888 (SM22CALPONIN)
  
  1,563 - 1,578
  
  PRINTS
  PR00888 (SM22CALPONIN)
  
  1,479 - 1,495
  
  PRINTS
  PR00888 (SM22CALPONIN)
  
  1,495 - 1,510
  
  PRINTS
  PR00888 (SM22CALPONIN)
  
  1,446 - 1,461
  
  PRINTS
  PR00888 (SM22CALPONIN)
IPR001997

Calponin/LIMCH1
1. PR00889 (CALPONIN)
  
  1,427 - 1,441
  
  PRINTS
  PR00889 (CALPONIN)
  
  1,457 - 1,474
  
  PRINTS
  PR00889 (CALPONIN)
  
  1,509 - 1,524
  
  PRINTS
  PR00889 (CALPONIN)
  
  1,580 - 1,586
  
  PRINTS
  PR00889 (CALPONIN)
IPR006579

Pre-C2HC domain
1. PF07530 (PRE_C2HC)
  
  278 - 344
  
  Pfam
  PF07530 (PRE_C2HC)
2. SM00596 (115neu5)
  
  275 - 345
  
  SMART
  SM00596 (115neu5)
IPR001878

Zinc finger, CCHC-type
1. PS50158 (ZF_CCHC)
  
  347 - 360
  
  PROSITE profiles
  PS50158 (ZF_CCHC)
IPR005135

Endonuclease/exonuclease/phosphatase
1. G3DSA:3.60.10.10
  
  544 - 755
  
  GENE3D
  G3DSA:3.60.10.10 (G3DSA:3.60.10.10)
2. PF14529 (Exo_endo_p...)
  
  638 - 750
  
  Pfam
  PF14529 (Exo_endo_phos_2)
3. SSF56219 (DNase I-like)
  
  543 - 755
  
  SUPERFAMILY
  SSF56219 (DNase I-like)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,037 - 1,304
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  1,018 - 1,304
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR001715

Calponin homology domain
1. G3DSA:1.10.41...
  
  1,422 - 1,575
  
  GENE3D
  G3DSA:1.10.418.10 (G3DSA:1.10.418.10)
2. SM00033 (ch_5)
  
  1,425 - 1,523
  
  SMART
  SM00033 (ch_5)
3. PF00307 (CH)
  
  1,424 - 1,528
  
  Pfam
  PF00307 (CH)
4. PS50021 (CH)
  
  1,423 - 1,527
  
  PROSITE profiles
  PS50021 (CH)
5. cd00014 (CH)
  
  1,424 - 1,528
  
  CDD
  cd00014 (CH)
6. SSF47576 (Calponin-...)
  
  1,420 - 1,572
  
  SUPERFAMILY
  SSF47576 (Calponin-homology domain, CH-domain)
IPR000557

Calponin repeat
1. PF00402 (Calponin)
  
  1,562 - 1,585
  
  Pfam
  PF00402 (Calponin)
2. PS51122 (CALPONIN_2)
  
  1,562 - 1,586
  
  PROSITE profiles
  PS51122 (CALPONIN_2)

no IPR

Unintegrated signatures

SSF56672 (DNA/RNA p...)

931 - 1,259

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd01650 (RT_nLTR_like)

1,034 - 1,304

CDD
cd01650 (RT_nLTR_like)
mobidb-lite (disord...)

56 - 194

MobiDB Lite
mobidb-lite (disorder_prediction)

453 - 474

MobiDB Lite
mobidb-lite (disorder_prediction)

406 - 433

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative NTP bindi...

1,123D

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,124I

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,125A

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,126K

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,127A

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,128F

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,182Q

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)

1,211D

putative NTP binding site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,211D
CDD
cd01650 (RT_nLTR_like)
putative active si...

1,123D

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,124I

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,125A

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,126K

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,127A

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,128F

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,182Q

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,183G

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,209F

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,211D

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,212D

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,300L

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)

1,301G

putative active site
1,123D, 1,124I, 1,125A, 1,126K, 1,127A, 1,128F, 1,182Q, 1,183G, 1,209F, 1,211D, 1,212D, 1,300L, 1,301G
CDD
cd01650 (RT_nLTR_like)
putative nucleic a...

1,183G

putative nucleic acid binding site
1,183G
CDD
cd01650 (RT_nLTR_like)
putative actin bin...

1,424D

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,425Q

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,427Q

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,428E

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,429V

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,432W

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,435D

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,488Q

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,489A

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,492K

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,495G

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,497P

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,514P

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,515Q

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,518L

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,519C

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,521Y

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,522A

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,525R

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

1,526I

putative actin binding surface
1,424D, 1,425Q, 1,427Q, 1,428E, 1,429V, 1,432W, 1,435D, 1,488Q, 1,489A, 1,492K, 1,495G, 1,497P, 1,514P, 1,515Q, 1,518L, 1,519C, 1,521Y, 1,522A, 1,525R, 1,526I
CDD
cd00014 (CH)

GO term prediction

Biological Process

GO:0031032 actomyosin structure organization

Molecular Function

GO:0003676 nucleic acid binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features