KWMTBOMO06993

Protein

Length

4,741 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
4,338 - 4,477
MAD homology 1, Dwarfin-type (IPR003619)
MAD homology, MH1 (IPR013019)
4,523 - 4,741
SMAD/FHA domain (IPR008984)
SMAD domain-like (IPR017855)
SMAD domain, Dwarfin-type (IPR001132)

1 500 1000 1500 2000 2500 3000 3500 4000 4741

Detailed signature matches

IPR003619

MAD homology 1, Dwarfin-type
1. PF03165 (MH1)
  
  4,364 - 4,464
  
  Pfam
  PF03165 (MH1)
2. SM00523 (dwAneu5)
  
  4,358 - 4,467
  
  SMART
  SM00523 (dwAneu5)
IPR013019

MAD homology, MH1
1. SSF56366 (SMAD MH1 ...)
  
  4,346 - 4,464
  
  SUPERFAMILY
  SSF56366 (SMAD MH1 domain)
2. PS51075 (MH1)
  
  4,345 - 4,469
  
  PROSITE profiles
  PS51075 (MH1)
3. G3DSA:3.90.52...
  
  4,338 - 4,477
  
  GENE3D
  G3DSA:3.90.520.10 (G3DSA:3.90.520.10)
IPR008984

SMAD/FHA domain
1. SSF49879 (SMAD/FHA ...)
  
  4,523 - 4,732
  
  SUPERFAMILY
  SSF49879 (SMAD/FHA domain)
IPR017855

SMAD domain-like
1. G3DSA:2.60.20...
  
  4,539 - 4,741
  
  GENE3D
  G3DSA:2.60.200.10 (G3DSA:2.60.200.10)
IPR001132

SMAD domain, Dwarfin-type
1. PS51076 (MH2)
  
  4,547 - 4,741
  
  PROSITE profiles
  PS51076 (MH2)
2. SM00524 (dwBultra2)
  
  4,545 - 4,717
  
  SMART
  SM00524 (dwBultra2)
3. PF03166 (MH2)
  
  4,546 - 4,717
  
  Pfam
  PF03166 (MH2)

no IPR

Unintegrated signatures

Coil

4,367 - 4,387

COILS
Coil (Coil)

231 - 261

COILS
Coil (Coil)

271 - 295

COILS
Coil (Coil)
cd10490 (MH1_SMAD_1...)

4,342 - 4,465

CDD
cd10490 (MH1_SMAD_1_5_9)
cd10497 (MH2_SMAD_1...)

4,541 - 4,741

CDD
cd10497 (MH2_SMAD_1_5_9)
mobidb-lite (disord...)

193 - 216

MobiDB Lite
mobidb-lite (disorder_prediction)

3,580 - 4,001

MobiDB Lite
mobidb-lite (disorder_prediction)

4,497 - 4,536

MobiDB Lite
mobidb-lite (disorder_prediction)

336 - 3,557

MobiDB Lite
mobidb-lite (disorder_prediction)

279 - 306

MobiDB Lite
mobidb-lite (disorder_prediction)

4,202 - 4,236

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 28

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

DNA binding site c...

4,365K

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,369S

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,403S

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,404L

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,407R

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,408L

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,409Q

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,410V

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,411S

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,414K

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,433H

DNA binding site
4,365K, 4,369S, 4,403S, 4,404L, 4,407R, 4,408L, 4,409Q, 4,410V, 4,411S, 4,414K, 4,433H
CDD
cd10490 (MH1_SMAD_1_5_9)
Zn binding site cd...

4,397C

Zn binding site
4,397C, 4,442C, 4,454C, 4,459H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,442C

Zn binding site
4,397C, 4,442C, 4,454C, 4,459H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,454C

Zn binding site
4,397C, 4,442C, 4,454C, 4,459H
CDD
cd10490 (MH1_SMAD_1_5_9)

4,459H

Zn binding site
4,397C, 4,442C, 4,454C, 4,459H
CDD
cd10490 (MH1_SMAD_1_5_9)
trimer interface c...

4,545L

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,556N

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,561E

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,562V

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,564H

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,575F

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,576T

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,577D

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,578P

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,579S

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,584R

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,588G

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,589Q

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,591S

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,593V

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,594N

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,600E

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,601N

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,603R

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,604R

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,605H

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,608K

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,627A

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,677E

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,680Y

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,683T

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,687T

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,689R

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,693V

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,694K

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,695G

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,700Y

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,702R

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,706T

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,711W

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,713E

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,715H

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,717H

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,720L

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,721Q

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,723L

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,724D

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,727L

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,728T

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,732S

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,733P

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,734H

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,735N

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,737I

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,738S

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,739S

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,740V

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

4,741S

trimer interface
4,545L, 4,556N, 4,561E, 4,562V, 4,564H, 4,575F, 4,576T, 4,577D, 4,578P, 4,579S, 4,584R, 4,588G, 4,589Q, 4,591S, 4,593V, 4,594N, 4,600E, 4,601N, 4,603R, 4,604R, 4,605H, 4,608K, 4,627A, 4,677E, 4,680Y, 4,683T, 4,687T, 4,689R, 4,693V, 4,694K, 4,695G, 4,700Y, 4,702R, 4,706T, 4,711W, 4,713E, 4,715H, 4,717H, 4,720L, 4,721Q, 4,723L, 4,724D, 4,727L, 4,728T, 4,732S, 4,733P, 4,734H, 4,735N, 4,737I, 4,738S, 4,739S, 4,740V, 4,741S
CDD
cd10497 (MH2_SMAD_1_5_9)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway

Molecular Function

GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding

Cellular Component

GO:0005622 intracellular
GO:0005667 transcription factor complex

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Entry type

Status

Per-residue features