KWMTBOMO06814

Protein

Length

2,118 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
247 - 357
Immunoglobulin-like fold (IPR013783)
Immunoglobulin-like domain (IPR007110)
Immunoglobulin subtype 2 (IPR003598)
360 - 457
Immunoglobulin-like fold (IPR013783)
Immunoglobulin-like domain (IPR007110)
Immunoglobulin subtype 2 (IPR003598)
457 - 548
Immunoglobulin-like fold (IPR013783)
Immunoglobulin-like domain (IPR007110)
Immunoglobulin subtype 2 (IPR003598)
547 - 741
Immunoglobulin-like fold (IPR013783)
Fibronectin type III (IPR003961)
738 - 945
Immunoglobulin-like fold (IPR013783)
Fibronectin type III (IPR003961)
941 - 1,136
Immunoglobulin-like fold (IPR013783)
Fibronectin type III (IPR003961)
1,136 - 1,375
Immunoglobulin-like fold (IPR013783)
Fibronectin type III (IPR003961)
1,539 - 1,861
Protein-tyrosine phosphatase-like (IPR029021)
Tyrosine specific protein phosphatases domain (IPR000387)
PTP type protein phosphatase (IPR000242)
1,820 - 2,117
Protein-tyrosine phosphatase-like (IPR029021)
Tyrosine specific protein phosphatases domain (IPR000387)
PTP type protein phosphatase (IPR000242)
Domain
250 - 349
Immunoglobulin I-set (IPR013098)
360 - 446
Immunoglobulin I-set (IPR013098)
1,719 - 1,820
Protein-tyrosine phosphatase, catalytic (IPR003595)
2,005 - 2,108
Protein-tyrosine phosphatase, catalytic (IPR003595)
Domain
256 - 350
Immunoglobulin subtype (IPR003599)
366 - 453
Immunoglobulin subtype (IPR003599)
466 - 545
Immunoglobulin subtype (IPR003599)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2118

Detailed signature matches

IPR013783

Immunoglobulin-like fold
1. G3DSA:2.60.40.10
  
  738 - 829
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  958 - 1,035
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  457 - 548
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  1,228 - 1,340
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  830 - 945
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  1,137 - 1,227
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  1,036 - 1,136
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  381 - 446
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  247 - 291
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  325 - 331
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  642 - 737
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
  
  549 - 641
  
  GENE3D
  G3DSA:2.60.40.10 (G3DSA:2.60.40.10)
IPR007110

Immunoglobulin-like domain
1. SSF48726 (Immunoglo...)
  
  360 - 457
  
  SUPERFAMILY
  SSF48726 (Immunoglobulin)
  
  457 - 544
  
  SUPERFAMILY
  SSF48726 (Immunoglobulin)
  
  249 - 357
  
  SUPERFAMILY
  SSF48726 (Immunoglobulin)
2. PS50835 (IG_LIKE)
  
  250 - 348
  
  PROSITE profiles
  PS50835 (IG_LIKE)
  
  360 - 445
  
  PROSITE profiles
  PS50835 (IG_LIKE)
  
  459 - 543
  
  PROSITE profiles
  PS50835 (IG_LIKE)
IPR013098

Immunoglobulin I-set
1. PF07679 (I-set)
  
  360 - 446
  
  Pfam
  PF07679 (I-set)
  
  250 - 349
  
  Pfam
  PF07679 (I-set)
IPR003599

Immunoglobulin subtype
1. SM00409 (IG_3c)
  
  256 - 350
  
  SMART
  SM00409 (IG_3c)
  
  366 - 453
  
  SMART
  SM00409 (IG_3c)
  
  466 - 545
  
  SMART
  SM00409 (IG_3c)
IPR003961

Fibronectin type III
1. cd00063 (FN3)
  
  1,040 - 1,131
  
  CDD
  cd00063 (FN3)
  
  1,234 - 1,332
  
  CDD
  cd00063 (FN3)
  
  644 - 736
  
  CDD
  cd00063 (FN3)
  
  836 - 936
  
  CDD
  cd00063 (FN3)
  
  958 - 1,027
  
  CDD
  cd00063 (FN3)
  
  548 - 637
  
  CDD
  cd00063 (FN3)
  
  741 - 831
  
  CDD
  cd00063 (FN3)
  
  1,138 - 1,228
  
  CDD
  cd00063 (FN3)
2. SM00060 (FN3_2)
  
  1,230 - 1,323
  
  SMART
  SM00060 (FN3_2)
  
  1,136 - 1,218
  
  SMART
  SM00060 (FN3_2)
  
  548 - 627
  
  SMART
  SM00060 (FN3_2)
  
  643 - 726
  
  SMART
  SM00060 (FN3_2)
  
  1,039 - 1,121
  
  SMART
  SM00060 (FN3_2)
  
  836 - 926
  
  SMART
  SM00060 (FN3_2)
  
  941 - 1,024
  
  SMART
  SM00060 (FN3_2)
  
  741 - 821
  
  SMART
  SM00060 (FN3_2)
3. SSF49265 (Fibronect...)
  
  739 - 941
  
  SUPERFAMILY
  SSF49265 (Fibronectin type III)
  
  1,233 - 1,375
  
  SUPERFAMILY
  SSF49265 (Fibronectin type III)
  
  1,138 - 1,269
  
  SUPERFAMILY
  SSF49265 (Fibronectin type III)
  
  958 - 1,133
  
  SUPERFAMILY
  SSF49265 (Fibronectin type III)
  
  547 - 741
  
  SUPERFAMILY
  SSF49265 (Fibronectin type III)
4. PF00041 (fn3)
  
  1,041 - 1,124
  
  Pfam
  PF00041 (fn3)
  
  550 - 630
  
  Pfam
  PF00041 (fn3)
  
  644 - 729
  
  Pfam
  PF00041 (fn3)
  
  838 - 929
  
  Pfam
  PF00041 (fn3)
  
  958 - 1,026
  
  Pfam
  PF00041 (fn3)
  
  1,138 - 1,221
  
  Pfam
  PF00041 (fn3)
  
  742 - 822
  
  Pfam
  PF00041 (fn3)
  
  1,234 - 1,319
  
  Pfam
  PF00041 (fn3)
5. PS50853 (FN3)
  
  1,233 - 1,335
  
  PROSITE profiles
  PS50853 (FN3)
  
  743 - 834
  
  PROSITE profiles
  PS50853 (FN3)
  
  1,041 - 1,134
  
  PROSITE profiles
  PS50853 (FN3)
  
  1,138 - 1,231
  
  PROSITE profiles
  PS50853 (FN3)
  
  645 - 739
  
  PROSITE profiles
  PS50853 (FN3)
  
  944 - 1,037
  
  PROSITE profiles
  PS50853 (FN3)
  
  550 - 640
  
  PROSITE profiles
  PS50853 (FN3)
  
  838 - 939
  
  PROSITE profiles
  PS50853 (FN3)
IPR003598

Immunoglobulin subtype 2
1. SM00408 (igc2_5)
  
  372 - 441
  
  SMART
  SM00408 (igc2_5)
  
  262 - 338
  
  SMART
  SM00408 (igc2_5)
  
  472 - 534
  
  SMART
  SM00408 (igc2_5)
IPR029021

Protein-tyrosine phosphatase-like
1. G3DSA:3.90.19...
  
  1,826 - 2,117
  
  GENE3D
  G3DSA:3.90.190.10 (G3DSA:3.90.190.10)
  
  1,539 - 1,823
  
  GENE3D
  G3DSA:3.90.190.10 (G3DSA:3.90.190.10)
2. SSF52799 ((Phosphot...)
  
  1,820 - 2,116
  
  SUPERFAMILY
  SSF52799 ((Phosphotyrosine protein) phosphatases II)
  
  1,553 - 1,861
  
  SUPERFAMILY
  SSF52799 ((Phosphotyrosine protein) phosphatases II)
IPR000387

Tyrosine specific protein phosphatases domain
1. PS50056 (TYR_PHOSPH...)
  
  1,741 - 1,812
  
  PROSITE profiles
  PS50056 (TYR_PHOSPHATASE_2)
  
  2,027 - 2,100
  
  PROSITE profiles
  PS50056 (TYR_PHOSPHATASE_2)
IPR000242

PTP type protein phosphatase
1. PS50055 (TYR_PHOSPH...)
  
  1,566 - 1,821
  
  PROSITE profiles
  PS50055 (TYR_PHOSPHATASE_PTP)
  
  1,853 - 2,109
  
  PROSITE profiles
  PS50055 (TYR_PHOSPHATASE_PTP)
2. SM00194 (PTPc_3)
  
  1,852 - 2,111
  
  SMART
  SM00194 (PTPc_3)
  
  1,565 - 1,823
  
  SMART
  SM00194 (PTPc_3)
3. PF00102 (Y_phosphatase)
  
  1,589 - 1,820
  
  Pfam
  PF00102 (Y_phosphatase)
  
  1,878 - 2,108
  
  Pfam
  PF00102 (Y_phosphatase)
4. PR00700 (PRTYPHPHTASE)
  
  1,757 - 1,775
  
  PRINTS
  PR00700 (PRTYPHPHTASE)
  
  1,718 - 1,735
  
  PRINTS
  PR00700 (PRTYPHPHTASE)
  
  1,788 - 1,803
  
  PRINTS
  PR00700 (PRTYPHPHTASE)
  
  1,634 - 1,654
  
  PRINTS
  PR00700 (PRTYPHPHTASE)
  
  1,618 - 1,625
  
  PRINTS
  PR00700 (PRTYPHPHTASE)
  
  1,804 - 1,814
  
  PRINTS
  PR00700 (PRTYPHPHTASE)
IPR003595

Protein-tyrosine phosphatase, catalytic
1. SM00404 (ptp_7)
  
  2,005 - 2,108
  
  SMART
  SM00404 (ptp_7)
  
  1,719 - 1,820
  
  SMART
  SM00404 (ptp_7)
IPR016130

Protein-tyrosine phosphatase, active site
1. PS00383 (TYR_PHOSPH...)
  
  2,048 - 2,058
  
  PROSITE patterns
  PS00383 (TYR_PHOSPHATASE_1)
  
  1,760 - 1,770
  
  PROSITE patterns
  PS00383 (TYR_PHOSPHATASE_1)

no IPR

Unintegrated signatures

cd00047 (PTPc)

1,880 - 2,108

CDD
cd00047 (PTPc)

1,591 - 1,820

CDD
cd00047 (PTPc)
mobidb-lite (disord...)

120 - 178

MobiDB Lite
mobidb-lite (disorder_prediction)

1,474 - 1,495

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 82

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Interdomain contac...

548P

Interdomain contacts
548P, 610P, 625G
CDD
cd00063 (FN3)

610P

Interdomain contacts
548P, 610P, 625G
CDD
cd00063 (FN3)

625G

Interdomain contacts
548P, 610P, 625G
CDD
cd00063 (FN3)
Cytokine receptor ...

626R

Cytokine receptor motif
626R, 627G, 629P, 630S
CDD
cd00063 (FN3)

627G

Cytokine receptor motif
626R, 627G, 629P, 630S
CDD
cd00063 (FN3)

629P

Cytokine receptor motif
626R, 627G, 629P, 630S
CDD
cd00063 (FN3)

630S

Cytokine receptor motif
626R, 627G, 629P, 630S
CDD
cd00063 (FN3)
Interdomain contac...

709P

Interdomain contacts
709P, 724G
CDD
cd00063 (FN3)

724G

Interdomain contacts
709P, 724G
CDD
cd00063 (FN3)
Cytokine receptor ...

725P

Cytokine receptor motif
725P, 726G, 728I, 729S
CDD
cd00063 (FN3)

726G

Cytokine receptor motif
725P, 726G, 728I, 729S
CDD
cd00063 (FN3)

728I

Cytokine receptor motif
725P, 726G, 728I, 729S
CDD
cd00063 (FN3)

729S

Cytokine receptor motif
725P, 726G, 728I, 729S
CDD
cd00063 (FN3)
Interdomain contac...

741P

Interdomain contacts
741P, 804P, 819G
CDD
cd00063 (FN3)

804P

Interdomain contacts
741P, 804P, 819G
CDD
cd00063 (FN3)

819G

Interdomain contacts
741P, 804P, 819G
CDD
cd00063 (FN3)
Cytokine receptor ...

820E

Cytokine receptor motif
820E, 821G, 823T, 824T
CDD
cd00063 (FN3)

821G

Cytokine receptor motif
820E, 821G, 823T, 824T
CDD
cd00063 (FN3)

823T

Cytokine receptor motif
820E, 821G, 823T, 824T
CDD
cd00063 (FN3)

824T

Cytokine receptor motif
820E, 821G, 823T, 824T
CDD
cd00063 (FN3)
Interdomain contac...

836P

Interdomain contacts
836P, 909P, 924G
CDD
cd00063 (FN3)

909P

Interdomain contacts
836P, 909P, 924G
CDD
cd00063 (FN3)

924G

Interdomain contacts
836P, 909P, 924G
CDD
cd00063 (FN3)
Cytokine receptor ...

925D

Cytokine receptor motif
925D, 926G, 928R, 929S
CDD
cd00063 (FN3)

926G

Cytokine receptor motif
925D, 926G, 928R, 929S
CDD
cd00063 (FN3)

928R

Cytokine receptor motif
925D, 926G, 928R, 929S
CDD
cd00063 (FN3)

929S

Cytokine receptor motif
925D, 926G, 928R, 929S
CDD
cd00063 (FN3)
Interdomain contac...

1,007R

Interdomain contacts
1,007R, 1,022G
CDD
cd00063 (FN3)

1,022G

Interdomain contacts
1,007R, 1,022G
CDD
cd00063 (FN3)
Cytokine receptor ...

1,023V

Cytokine receptor motif
1,023V, 1,024G, 1,026E, 1,027T
CDD
cd00063 (FN3)

1,024G

Cytokine receptor motif
1,023V, 1,024G, 1,026E, 1,027T
CDD
cd00063 (FN3)

1,026E

Cytokine receptor motif
1,023V, 1,024G, 1,026E, 1,027T
CDD
cd00063 (FN3)

1,027T

Cytokine receptor motif
1,023V, 1,024G, 1,026E, 1,027T
CDD
cd00063 (FN3)
Interdomain contac...

1,104E

Interdomain contacts
1,104E, 1,119G
CDD
cd00063 (FN3)

1,119G

Interdomain contacts
1,104E, 1,119G
CDD
cd00063 (FN3)
Cytokine receptor ...

1,120P

Cytokine receptor motif
1,120P, 1,121G, 1,123Y, 1,124S
CDD
cd00063 (FN3)

1,121G

Cytokine receptor motif
1,120P, 1,121G, 1,123Y, 1,124S
CDD
cd00063 (FN3)

1,123Y

Cytokine receptor motif
1,120P, 1,121G, 1,123Y, 1,124S
CDD
cd00063 (FN3)

1,124S

Cytokine receptor motif
1,120P, 1,121G, 1,123Y, 1,124S
CDD
cd00063 (FN3)
Interdomain contac...

1,201T

Interdomain contacts
1,201T, 1,216G
CDD
cd00063 (FN3)

1,216G

Interdomain contacts
1,201T, 1,216G
CDD
cd00063 (FN3)
Cytokine receptor ...

1,217L

Cytokine receptor motif
1,217L, 1,218G, 1,220L, 1,221S
CDD
cd00063 (FN3)

1,218G

Cytokine receptor motif
1,217L, 1,218G, 1,220L, 1,221S
CDD
cd00063 (FN3)

1,220L

Cytokine receptor motif
1,217L, 1,218G, 1,220L, 1,221S
CDD
cd00063 (FN3)

1,221S

Cytokine receptor motif
1,217L, 1,218G, 1,220L, 1,221S
CDD
cd00063 (FN3)
Interdomain contac...

1,305P

Interdomain contacts
1,305P, 1,320D
CDD
cd00063 (FN3)

1,320D

Interdomain contacts
1,305P, 1,320D
CDD
cd00063 (FN3)
Cytokine receptor ...

1,321S

Cytokine receptor motif
1,321S, 1,322Y, 1,324P, 1,325P
CDD
cd00063 (FN3)

1,322Y

Cytokine receptor motif
1,321S, 1,322Y, 1,324P, 1,325P
CDD
cd00063 (FN3)

1,324P

Cytokine receptor motif
1,321S, 1,322Y, 1,324P, 1,325P
CDD
cd00063 (FN3)

1,325P

Cytokine receptor motif
1,321S, 1,322Y, 1,324P, 1,325P
CDD
cd00063 (FN3)
active site cd00047

1,730D

active site
1,730D, 1,761H, 1,762C, 1,765G, 1,768R, 1,769T
CDD
cd00047 (PTPc)

1,761H

active site
1,730D, 1,761H, 1,762C, 1,765G, 1,768R, 1,769T
CDD
cd00047 (PTPc)

1,762C

active site
1,730D, 1,761H, 1,762C, 1,765G, 1,768R, 1,769T
CDD
cd00047 (PTPc)

1,765G

active site
1,730D, 1,761H, 1,762C, 1,765G, 1,768R, 1,769T
CDD
cd00047 (PTPc)

1,768R

active site
1,730D, 1,761H, 1,762C, 1,765G, 1,768R, 1,769T
CDD
cd00047 (PTPc)

1,769T

active site
1,730D, 1,761H, 1,762C, 1,765G, 1,768R, 1,769T
CDD
cd00047 (PTPc)
active site cd00047

2,016E

active site
2,016E, 2,049H, 2,050C, 2,053G, 2,056R, 2,057T
CDD
cd00047 (PTPc)

2,049H

active site
2,016E, 2,049H, 2,050C, 2,053G, 2,056R, 2,057T
CDD
cd00047 (PTPc)

2,050C

active site
2,016E, 2,049H, 2,050C, 2,053G, 2,056R, 2,057T
CDD
cd00047 (PTPc)

2,053G

active site
2,016E, 2,049H, 2,050C, 2,053G, 2,056R, 2,057T
CDD
cd00047 (PTPc)

2,056R

active site
2,016E, 2,049H, 2,050C, 2,053G, 2,056R, 2,057T
CDD
cd00047 (PTPc)

2,057T

active site
2,016E, 2,049H, 2,050C, 2,053G, 2,056R, 2,057T
CDD
cd00047 (PTPc)

GO term prediction

Biological Process

GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity

Cellular Component