KWMTBOMO06289

Protein

Length

350 amino acids

Protein family membership

Galactose-1-phosphate uridyl transferase, class I (IPR001937)

Domains and repeats

Domain
2 - 173
Galactose-1-phosphate uridyl transferase, N-terminal (IPR005849)
181 - 348
Galactose-1-phosphate uridyl transferase, C-terminal (IPR005850)
Domain
3 - 174
HIT-like domain (IPR011146)
173 - 346
HIT-like domain (IPR011146)

1 50 100 150 200 250 300 350 350

Detailed signature matches

IPR001937

Galactose-1-phosphate uridyl transferase, class I
1. PIRSF000808 (GalT)
  
  1 - 342
  
  PIRSF
  PIRSF000808 (GalT)
2. TIGR00209
  
  2 - 349
  
  TIGRFAMs
  TIGR00209 (TIGR00209)
IPR005849

Galactose-1-phosphate uridyl transferase, N-terminal
1. PF01087 (GalP_UDP_t...)
  
  2 - 173
  
  Pfam
  PF01087 (GalP_UDP_transf)
IPR011146

HIT-like domain
1. SSF54197 (HIT-like)
  
  176 - 346
  
  SUPERFAMILY
  SSF54197 (HIT-like)
  
  3 - 174
  
  SUPERFAMILY
  SSF54197 (HIT-like)
2. G3DSA:3.30.42...
  
  44 - 172
  
  GENE3D
  G3DSA:3.30.428.10 (G3DSA:3.30.428.10)
  
  173 - 342
  
  GENE3D
  G3DSA:3.30.428.10 (G3DSA:3.30.428.10)
IPR005850

Galactose-1-phosphate uridyl transferase, C-terminal
1. PF02744 (GalP_UDP_tr_C)
  
  181 - 348
  
  Pfam
  PF02744 (GalP_UDP_tr_C)
IPR019779

Galactose-1-phosphate uridyl transferase, class I His-active site
1. PS00117 (GAL_P_UDP_...)
  
  148 - 165
  
  PROSITE patterns
  PS00117 (GAL_P_UDP_TRANSF_I)

no IPR

Unintegrated signatures

Coil

121 - 141

COILS
Coil (Coil)
cd00608 (GalT)

10 - 340

CDD
cd00608 (GalT)
mobidb-lite (disord...)

32 - 65

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface cd...

10H

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

11I

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

12R

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

13Y

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

15P

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

19E

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

20W

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

24S

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

27R

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

30R

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

32W

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

33S

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

34G

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

50P

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

78A

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

150N

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

153A

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

154I

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

155M

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

156G

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

158S

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

159N

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

167W

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

169S

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

171F

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

173P

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

174N

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

175E

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

186Y

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

201Q

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

208R

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

222Y

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

223W

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

226W

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

275S

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

279H

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

300L

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

313K

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

314F

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)

318F

dimer interface
10H, 11I, 12R, 13Y, 15P, 19E, 20W, 24S, 27R, 30R, 32W, 33S, 34G, 50P, 78A, 150N, 153A, 154I, 155M, 156G, 158S, 159N, 167W, 169S, 171F, 173P, 174N, 175E, 186Y, 201Q, 208R, 222Y, 223W, 226W, 275S, 279H, 300L, 313K, 314F, 318F
CDD
cd00608 (GalT)
active site cd00608

74N

active site
74N, 75D, 150N, 156G, 158S, 165Q
CDD
cd00608 (GalT)

75D

active site
74N, 75D, 150N, 156G, 158S, 165Q
CDD
cd00608 (GalT)

150N

active site
74N, 75D, 150N, 156G, 158S, 165Q
CDD
cd00608 (GalT)

156G

active site
74N, 75D, 150N, 156G, 158S, 165Q
CDD
cd00608 (GalT)

158S

active site
74N, 75D, 150N, 156G, 158S, 165Q
CDD
cd00608 (GalT)

165Q

active site
74N, 75D, 150N, 156G, 158S, 165Q
CDD
cd00608 (GalT)

GO term prediction

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008270 zinc ion binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features