KWMTBOMO05737

Protein

Length

473 amino acids

Protein family membership

Fumarate lyase family (IPR000362)
- Argininosuccinate lyase (IPR009049)

Domains and repeats

Domain
7 - 304
Fumarase/histidase, N-terminal (IPR024083)
Fumarate lyase, N-terminal (IPR022761)
371 - 440
Argininosuccinate lyase, C-terminal (IPR029419)
Domain
13 - 466
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 473

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  155 - 173
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  239 - 266
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  283 - 299
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  110 - 128
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR009049

Argininosuccinate lyase
1. TIGR00838
  
  8 - 459
  
  TIGRFAMs
  TIGR00838 (TIGR00838)
2. MF_00006 (Arg_succ_...)
  
  7 - 462
  
  HAMAP
  MF_00006 (Arg_succ_lyase)
3. cd01359 (Argininosu...)
  
  27 - 460
  
  CDD
  cd01359 (Argininosuccinate_lyase)
IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  7 - 114
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  13 - 466
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  17 - 304
  
  Pfam
  PF00206 (Lyase_1)
IPR029419

Argininosuccinate lyase, C-terminal
1. PF14698 (ASL_C2)
  
  371 - 440
  
  Pfam
  PF14698 (ASL_C2)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  283 - 292
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

Coil

67 - 87

COILS
Coil (Coil)
G3DSA:1.10.40.30

383 - 441

GENE3D
G3DSA:1.10.40.30 (G3DSA:1.10.40.30)
G3DSA:1.20.20...

115 - 382

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
PR00145 (ARGSUCLYASE)

283 - 299

PRINTS
PR00145 (ARGSUCLYASE)

150 - 170

PRINTS
PR00145 (ARGSUCLYASE)

109 - 131

PRINTS
PR00145 (ARGSUCLYASE)

239 - 263

PRINTS
PR00145 (ARGSUCLYASE)

201 - 217

PRINTS
PR00145 (ARGSUCLYASE)

318 - 337

PRINTS
PR00145 (ARGSUCLYASE)

Residue annotation

active sites cd01359

27S

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

31D

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

90D

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

92H

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

115S

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

116R

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

117N

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

120S

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

162T

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

163H

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

239R

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

282T

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

284S

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

292N

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

294D

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

297E

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

324Y

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

326K

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

329Q

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

331D

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)

332K

active sites
27S, 31D, 90D, 92H, 115S, 116R, 117N, 120S, 162T, 163H, 239R, 282T, 284S, 292N, 294D, 297E, 324Y, 326K, 329Q, 331D, 332K
CDD
cd01359 (Argininosuccinate_lyase)
tetramer interface...

105D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

108F

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

111H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

112T

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

161Y

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

162T

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

163H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

164L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

165Q

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

166R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

167A

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

168Q

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

174H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

178S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

179H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

185D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

188T

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

189R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

192E

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

196R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

207L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

208A

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

209G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

210C

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

211A

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

213T

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

216R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

230P

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

231N

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

232S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

233M

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

234F

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

237G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

238S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

240D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

244E

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

247N

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

251L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

254L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

255H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

257S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

258R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

261E

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

262D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

267S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

268S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

271Y

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

279Q

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

285S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

286L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

287M

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

288P

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

290K

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

291R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

292N

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

294D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

297E

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

298L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

300R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

301G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

302A

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

303A

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

304G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

305L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

307L

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

308G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

309E

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

312G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

314S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

315C

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

316V

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

324Y

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

325N

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

326K

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

327D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

330S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

333E

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

344D

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

347K

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

373A

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

378H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

382R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

387F

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

388R

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

391H

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

394V

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

442Y

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

444S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

445S

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

446G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

447G

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

448T

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

456Q

tetramer interface
105D, 108F, 111H, 112T, 161Y, 162T, 163H, 164L, 165Q, 166R, 167A, 168Q, 174H, 178S, 179H, 185D, 188T, 189R, 192E, 196R, 207L, 208A, 209G, 210C, 211A, 213T, 216R, 230P, 231N, 232S, 233M, 234F, 237G, 238S, 240D, 244E, 247N, 251L, 254L, 255H, 257S, 258R, 261E, 262D, 267S, 268S, 271Y, 279Q, 285S, 286L, 287M, 288P, 290K, 291R, 292N, 294D, 297E, 298L, 300R, 301G, 302A, 303A, 304G, 305L, 307L, 308G, 309E, 312G, 314S, 315C, 316V, 324Y, 325N, 326K, 327D, 330S, 333E, 344D, 347K, 373A, 378H, 382R, 387F, 388R, 391H, 394V, 442Y, 444S, 445S, 446G, 447G, 448T, 456Q
CDD
cd01359 (Argininosuccinate_lyase)

GO term prediction

Biological Process

GO:0042450 arginine biosynthetic process via ornithine

Molecular Function

GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features