KWMTBOMO05694

Protein

Length

285 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
15 - 279
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 285

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  20 - 215
  
  Pfam
  PF00106 (adh_short)
2. PR00080 (SDRFAMILY)
  
  153 - 161
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  173 - 192
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  100 - 111
  
  PRINTS
  PR00080 (SDRFAMILY)
3. PR00081 (GDHRDH)
  
  147 - 163
  
  PRINTS
  PR00081 (GDHRDH)
  
  194 - 211
  
  PRINTS
  PR00081 (GDHRDH)
  
  100 - 111
  
  PRINTS
  PR00081 (GDHRDH)
  
  173 - 192
  
  PRINTS
  PR00081 (GDHRDH)
  
  21 - 38
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  15 - 279
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
2. G3DSA:3.40.50...
  
  19 - 250
  
  GENE3D
  G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  160 - 188
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

SM00822 (PKS_KR)

20 - 209

SMART
SM00822 (PKS_KR)
cd05332 (11beta-HSD...)

17 - 277

CDD
cd05332 (11beta-HSD1_like_SDR_c)

Residue annotation

NADP binding site ...

26G

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

27A

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

28S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

29S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

30G

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

31I

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

50S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

51R

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

52R

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

80L

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

81N

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

82L

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

108N

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

109G

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

110G

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

112T

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

131I

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

136S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

158N

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

159S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

160S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

173Y

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

177K

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

203P

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

204G

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

205Y

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

206I

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

208T

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

210I

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)

211S

NADP binding site
26G, 27A, 28S, 29S, 30G, 31I, 50S, 51R, 52R, 80L, 81N, 82L, 108N, 109G, 110G, 112T, 131I, 136S, 158N, 159S, 160S, 173Y, 177K, 203P, 204G, 205Y, 206I, 208T, 210I, 211S
CDD
cd05332 (11beta-HSD1_like_SDR_c)
homodimer interfac...

85I

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

115G

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

116S

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

117I

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

118L

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

119N

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

122T

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

125D

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

126Q

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

129M

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

130F

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

133Y

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

134F

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

138A

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

141K

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

164L

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

165I

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

166S

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

167I

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

168P

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

169N

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

170R

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

171S

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

174A

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

175A

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

178H

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

179A

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

181Q

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

182A

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

183F

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

185D

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

186C

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

187L

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

189A

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

190E

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

217G

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

218S

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

219G

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

220D

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

221T

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

256S

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

265F

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

266L

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

268H

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

270F

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

271P

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

273L

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

274Y

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

275F

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)

277I

homodimer interface
85I, 115G, 116S, 117I, 118L, 119N, 122T, 125D, 126Q, 129M, 130F, 133Y, 134F, 138A, 141K, 164L, 165I, 166S, 167I, 168P, 169N, 170R, 171S, 174A, 175A, 178H, 179A, 181Q, 182A, 183F, 185D, 186C, 187L, 189A, 190E, 217G, 218S, 219G, 220D, 221T, 256S, 265F, 266L, 268H, 270F, 271P, 273L, 274Y, 275F, 277I
CDD
cd05332 (11beta-HSD1_like_SDR_c)
substrate binding ...

110G

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

113H

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

160S

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

161V

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

162Q

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

167I

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

170R

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

173Y

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

203P

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

204G

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

205Y

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

210I

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

211S

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

214A

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)

215F

substrate binding site
110G, 113H, 160S, 161V, 162Q, 167I, 170R, 173Y, 203P, 204G, 205Y, 210I, 211S, 214A, 215F
CDD
cd05332 (11beta-HSD1_like_SDR_c)
active site cd05332

132N

active site
132N, 160S, 173Y, 177K
CDD
cd05332 (11beta-HSD1_like_SDR_c)

160S

active site
132N, 160S, 173Y, 177K
CDD
cd05332 (11beta-HSD1_like_SDR_c)

173Y

active site
132N, 160S, 173Y, 177K
CDD
cd05332 (11beta-HSD1_like_SDR_c)

177K

active site
132N, 160S, 173Y, 177K
CDD
cd05332 (11beta-HSD1_like_SDR_c)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

KWMTBOMO05694

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component