KWMTBOMO05205

Protein

Length

591 amino acids

Protein family membership

AICARFT/IMPCHase bienzyme (IPR002695)

Domains and repeats

Domain
6 - 198
Methylglyoxal synthase-like domain (IPR011607)
204 - 591
Cytidine deaminase-like (IPR016193)
Domain
231 - 370
AICAR transformylase domain (IPR024051)
374 - 476
AICAR transformylase domain (IPR024051)
477 - 514
AICAR transformylase, insert domain (IPR024050)
521 - 581
AICAR transformylase domain (IPR024051)

1 100 200 300 400 500 591

Detailed signature matches

IPR002695

AICARFT/IMPCHase bienzyme
1. MF_00139 (PurH)
  
  5 - 591
  
  HAMAP
  MF_00139 (PurH)
2. PF01808 (AICARFT_IM...)
  
  136 - 458
  
  Pfam
  PF01808 (AICARFT_IMPCHas)
3. SM00798 (aicarft_im...)
  
  136 - 460
  
  SMART
  SM00798 (aicarft_impchas)
4. PIRSF000414 (PurH)
  
  1 - 591
  
  PIRSF
  PIRSF000414 (PurH)
5. TIGR00355
  
  6 - 591
  
  TIGRFAMs
  TIGR00355 (TIGR00355)
IPR011607

Methylglyoxal synthase-like domain
1. PF02142 (MGS)
  
  17 - 131
  
  Pfam
  PF02142 (MGS)
2. G3DSA:3.40.50...
  
  6 - 190
  
  GENE3D
  G3DSA:3.40.50.1380 (G3DSA:3.40.50.1380)
3. SSF52335 (Methylgly...)
  
  6 - 198
  
  SUPERFAMILY
  SSF52335 (Methylglyoxal synthase-like)
4. SM00851 (MGS_2a)
  
  17 - 131
  
  SMART
  SM00851 (MGS_2a)
IPR016193

Cytidine deaminase-like
1. SSF53927 (Cytidine ...)
  
  204 - 591
  
  SUPERFAMILY
  SSF53927 (Cytidine deaminase-like)
IPR024051

AICAR transformylase domain
1. G3DSA:3.40.14...
  
  374 - 476
  
  GENE3D
  G3DSA:3.40.140.20 (G3DSA:3.40.140.20)
  
  521 - 581
  
  GENE3D
  G3DSA:3.40.140.20 (G3DSA:3.40.140.20)
  
  231 - 370
  
  GENE3D
  G3DSA:3.40.140.20 (G3DSA:3.40.140.20)
IPR024050

AICAR transformylase, insert domain
1. G3DSA:1.10.28...
  
  477 - 514
  
  GENE3D
  G3DSA:1.10.287.440 (G3DSA:1.10.287.440)

no IPR

Unintegrated signatures

cd01421 (IMPCH)

6 - 194

CDD
cd01421 (IMPCH)

Residue annotation

purine monophospha...

13S

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

15K

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

35S

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

38T

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

67K

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

68T

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

103N

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)

126D

purine monophosphate binding site
13S, 15K, 35S, 38T, 67K, 68T, 103N, 126D
CDD
cd01421 (IMPCH)
dimer interface cd...

58A

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

61M

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

62L

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

65R

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

66V

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

69L

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

70H

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

71P

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

74H

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

75A

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

78L

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

125I

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

126D

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

127I

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

130V

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

134R

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

135A

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

138K

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

173Q

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

176A

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

177L

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

178K

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

186Y

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

187D

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

188L

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

190I

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

191S

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)

194F

dimer interface
58A, 61M, 62L, 65R, 66V, 69L, 70H, 71P, 74H, 75A, 78L, 125I, 126D, 127I, 130V, 134R, 135A, 138K, 173Q, 176A, 177L, 178K, 186Y, 187D, 188L, 190I, 191S, 194F
CDD
cd01421 (IMPCH)
putative catalytic...

67K

putative catalytic residues
67K, 126D
CDD
cd01421 (IMPCH)

126D

putative catalytic residues
67K, 126D
CDD
cd01421 (IMPCH)

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003937 IMP cyclohydrolase activity
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features